Mark Leo MICHAELS

Person

Encino, CA, US

People

Patents Grantslast 30 patents

Information Patent Grant
Methods of treating non-alcoholic steatohepatitis using FGF21 mutants
- Patent number 11,840,558
- Issue date Dec 12, 2023
- Amgen Inc.
- Edward John Belouski
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Bispecific-Fc molecules
- Patent number 11,753,475
- Issue date Sep 12, 2023
- Amgen Inc.
- Luis G. Borges
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Stabilized receptor polypeptides and uses thereof
- Patent number 11,685,770
- Issue date Jun 27, 2023
- Amgen Inc.
- Jeonghoon Sun
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Heterodimeric bispecific antibodies
- Patent number 11,634,502
- Issue date Apr 25, 2023
- Amgen Inc.
- Wei Yan
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Methods of treating non-alcoholic steatohepatitis using FGF21 mutants
- Patent number 11,072,640
- Issue date Jul 27, 2021
- Amgen Inc.
- Edward John Belouski
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Isolated nucleic acid molecules encoding stabilized receptor polype...
- Patent number 10,308,704
- Issue date Jun 4, 2019
- Amgen Inc.
- Jeonghoon Sun
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Variants of tissue inhibitor of metalloproteinase type three (TIMP-...
- Patent number 10,189,890
- Issue date Jan 29, 2019
- Amgen Inc.
- Jeonghoon Sun
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Methods of treating of diabetes and obesity using FGF21 mutants
- Patent number 10,011,642
- Issue date Jul 3, 2018
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitory polypeptides specific to WNT inhibitors
- Patent number 9,708,375
- Issue date Jul 18, 2017
- Amgen Inc.
- Ryan B. Case
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Variant Fc-polypeptides with enhanced binding to the neonatal Fc re...
- Patent number 9,688,756
- Issue date Jun 27, 2017
- Amgen Inc.
- Jeonghoon Sun
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Human FGF receptor and β-Klotho binding proteins
- Patent number 9,517,264
- Issue date Dec 13, 2016
- Amgen Inc.
- Roger Fachini
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
FGF21 mutants comprising a mutation at position 98, 171 and/or 180
- Patent number 9,493,530
- Issue date Nov 15, 2016
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
FGF-21 mutants comprising polyethylene glycol and uses thereof
- Patent number 9,279,013
- Issue date Mar 8, 2016
- Amgen Inc.
- Kenneth W. Walker
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
FGF mutants with reduced proteolysis and aggregation
- Patent number 9,273,106
- Issue date Mar 1, 2016
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Stabilized receptor polypeptides and uses thereof
- Patent number 9,273,114
- Issue date Mar 1, 2016
- Amgen Inc.
- Jeonghoon Sun
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
FGF21 polypeptides comprising two or more mutations and uses thereof
- Patent number 8,835,385
- Issue date Sep 16, 2014
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
FGF 21 polypeptides comprising two or more mutations and uses thereof
- Patent number 8,795,985
- Issue date Aug 5, 2014
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
FGF21 mutant fusion polypeptides and uses thereof
- Patent number 8,642,546
- Issue date Feb 4, 2014
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
FGF21 mutants multimers and uses thereof
- Patent number 8,618,053
- Issue date Dec 31, 2013
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
FGF21 mutants and uses thereof
- Patent number 8,410,051
- Issue date Apr 2, 2013
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Stabilized activin IIB receptor polypeptides and uses thereof
- Patent number 8,410,043
- Issue date Apr 2, 2013
- Atara Biotherapeutics, Inc.
- Jeonghoon Sun
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Uses of FGF21 polypeptides comprising two or more mutations
- Patent number 8,361,963
- Issue date Jan 29, 2013
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
FGF21 mutants and uses thereof
- Patent number 8,188,040
- Issue date May 29, 2012
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
FGF21 polypeptides comprising two or more mutations
- Patent number 8,034,770
- Issue date Oct 11, 2011
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Mutants of the green fluorescent protein having improved fluorescen...
- Patent number 6,096,865
- Issue date Aug 1, 2000
- Amgen Inc.
- Mark Michaels
- C07 - ORGANIC CHEMISTRY

Patents Applicationslast 30 patents

Information Patent Application
PAC1 ANTIBODIES AND USES THEREOF
- Publication number 20240150448
- Publication date May 9, 2024
- Amgen Inc.
- Neeraj Jagdish AGRAWAL
- C07 - ORGANIC CHEMISTRY
Information Patent Application
FGF21 Mutants and Uses Thereof
- Publication number 20240076333
- Publication date Mar 7, 2024
- Amgen Inc.
- Edward John Belouski
- C07 - ORGANIC CHEMISTRY
Information Patent Application
VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-...
- Publication number 20240010708
- Publication date Jan 11, 2024
- Amgen Inc.
- Jeonghoon Sun
- C07 - ORGANIC CHEMISTRY
Information Patent Application
STABILIZED RECEPTOR POLYPEPTIDES AND USES THEREOF
- Publication number 20230295267
- Publication date Sep 21, 2023
- Amgen Inc.
- Jeonghoon SUN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
BISPECIFIC FC MOLECULES
- Publication number 20230212297
- Publication date Jul 6, 2023
- Amgen Inc.
- Luis G. Borges
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PROTEASE-ACTIVATABLE BISPECIFIC PROTEINS
- Publication number 20230212318
- Publication date Jul 6, 2023
- Amgen Inc.
- Wei Yan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Heterodimeric Bispecific Antibodies
- Publication number 20230077648
- Publication date Mar 16, 2023
- Amgen Inc.
- Wei Yan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
V-C-FC-V-C ANTIBODY
- Publication number 20230055407
- Publication date Feb 23, 2023
- Amgen Inc.
- Mark L. Michaels
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ENGINEERED NRG-1 VARIANTS WITH IMPROVED SELECTIVITY TOWARD ErbB4 BU...
- Publication number 20220402985
- Publication date Dec 22, 2022
- Amgen Inc.
- Darren L. BATES
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTI-CGRP RECEPTOR/ANTI-PAC1 RECEPTOR BISPECIFIC ANTIGEN BINDING PR...
- Publication number 20220363770
- Publication date Nov 17, 2022
- Amgen Inc.
- Irwin CHEN
- C07 - ORGANIC CHEMISTRY
Information Patent Application
PAC1 ANTIBODIES AND USES THEREOF
- Publication number 20220195022
- Publication date Jun 23, 2022
- Amgen Inc.
- Neeraj Jagdish AGRAWAL
- C07 - ORGANIC CHEMISTRY
Information Patent Application
FG21 MUTANTS AND USES THEREOF
- Publication number 20210317176
- Publication date Oct 14, 2021
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING BINDIN...
- Publication number 20210087286
- Publication date Mar 25, 2021
- Amgen Inc.
- Darren L. BATES
- C07 - ORGANIC CHEMISTRY
Information Patent Application
PAC1 ANTIBODIES AND USES THEREOF
- Publication number 20210017261
- Publication date Jan 21, 2021
- Amgen Inc.
- Neeraj Jagdish AGRAWAL
- C07 - ORGANIC CHEMISTRY
Information Patent Application
STABILIZED RECEPTOR POLYPEPTIDES AND USES THEREOF
- Publication number 20200283504
- Publication date Sep 10, 2020
- Amgen Inc.
- Jeonghoon SUN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Heterodimeric Bispecific Antibodies
- Publication number 20200071425
- Publication date Mar 5, 2020
- Amgen Inc.
- Wei Yan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
V-C-FC-V-C ANTIBODY
- Publication number 20200040075
- Publication date Feb 6, 2020
- Amgen Inc.
- Mark L. Michaels
- C07 - ORGANIC CHEMISTRY
Information Patent Application
STABILIZED RECEPTOR POLYPEPTIDES AND USES THEREOF
- Publication number 20190389932
- Publication date Dec 26, 2019
- Amgen Inc.
- Jeonghoon SUN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PAC1 ANTIBODIES AND USES THEREOF
- Publication number 20190218279
- Publication date Jul 18, 2019
- Amgen Inc.
- Neeraj Jagdish AGRAWAL
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-...
- Publication number 20190085054
- Publication date Mar 21, 2019
- Amgen Inc.
- Jeonghoon Sun
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
FGF21 Mutants and Uses Thereof
- Publication number 20190023757
- Publication date Jan 24, 2019
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
BISPECIFIC FC MOLECULES
- Publication number 20190002568
- Publication date Jan 3, 2019
- Amgen Inc.
- Luis G. Borges
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
BISPECIFIC-FC MOLECULES
- Publication number 20180230220
- Publication date Aug 16, 2018
- Amgen Inc.
- Luis G. Borges
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PROTEASE-ACTIVATABLE BISPECIFIC PROTEINS
- Publication number 20170247476
- Publication date Aug 31, 2017
- Amgen Inc.
- Wei Yan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Stabilized Receptor Polypeptides and Uses Thereof
- Publication number 20170183391
- Publication date Jun 29, 2017
- Amgen Inc.
- Jeonghoon Sun
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
V-C-FC-V-C ANTIBODY
- Publication number 20160257748
- Publication date Sep 8, 2016
- Amgen Inc.
- Mark L. Michaels
- C07 - ORGANIC CHEMISTRY
Information Patent Application
FGF21 MUTANTS AND USES THEREOF
- Publication number 20160244497
- Publication date Aug 25, 2016
- Amgen Inc.
- Kenneth W. WALKER
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
FGF MUTANTS AND USES THEREOF
- Publication number 20160168223
- Publication date Jun 16, 2016
- Amgen Inc.
- Edward John Belouski
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
BISPECIFIC-FC MOLECULES
- Publication number 20160145340
- Publication date May 26, 2016
- AMEGEN INC.
- Luis G. Borges
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Stabilized Receptor Polypeptides and Uses Thereof
- Publication number 20160137718
- Publication date May 19, 2016
- Amgen Inc.
- Jeonghoon Sun
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Mark Leo MICHAELS

Person

Patents Grantslast 30 patents

Methods of treating non-alcoholic steatohepatitis using FGF21 mutants

Bispecific-Fc molecules

Stabilized receptor polypeptides and uses thereof

Heterodimeric bispecific antibodies

Methods of treating non-alcoholic steatohepatitis using FGF21 mutants

Isolated nucleic acid molecules encoding stabilized receptor polype...

Variants of tissue inhibitor of metalloproteinase type three (TIMP-...

Methods of treating of diabetes and obesity using FGF21 mutants

Inhibitory polypeptides specific to WNT inhibitors

Variant Fc-polypeptides with enhanced binding to the neonatal Fc re...

Human FGF receptor and β-Klotho binding proteins

FGF21 mutants comprising a mutation at position 98, 171 and/or 180

FGF-21 mutants comprising polyethylene glycol and uses thereof

FGF mutants with reduced proteolysis and aggregation

Stabilized receptor polypeptides and uses thereof

FGF21 polypeptides comprising two or more mutations and uses thereof

FGF 21 polypeptides comprising two or more mutations and uses thereof

FGF21 mutant fusion polypeptides and uses thereof

FGF21 mutants multimers and uses thereof

FGF21 mutants and uses thereof

Stabilized activin IIB receptor polypeptides and uses thereof

Uses of FGF21 polypeptides comprising two or more mutations

FGF21 mutants and uses thereof

FGF21 polypeptides comprising two or more mutations

Mutants of the green fluorescent protein having improved fluorescen...

Patents Applicationslast 30 patents

PAC1 ANTIBODIES AND USES THEREOF

FGF21 Mutants and Uses Thereof

VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-...

STABILIZED RECEPTOR POLYPEPTIDES AND USES THEREOF

BISPECIFIC FC MOLECULES

PROTEASE-ACTIVATABLE BISPECIFIC PROTEINS

Heterodimeric Bispecific Antibodies

V-C-FC-V-C ANTIBODY

ENGINEERED NRG-1 VARIANTS WITH IMPROVED SELECTIVITY TOWARD ErbB4 BU...

ANTI-CGRP RECEPTOR/ANTI-PAC1 RECEPTOR BISPECIFIC ANTIGEN BINDING PR...

PAC1 ANTIBODIES AND USES THEREOF

FG21 MUTANTS AND USES THEREOF

METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING BINDIN...

PAC1 ANTIBODIES AND USES THEREOF

STABILIZED RECEPTOR POLYPEPTIDES AND USES THEREOF

Heterodimeric Bispecific Antibodies

V-C-FC-V-C ANTIBODY

STABILIZED RECEPTOR POLYPEPTIDES AND USES THEREOF

PAC1 ANTIBODIES AND USES THEREOF

VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-...

FGF21 Mutants and Uses Thereof

BISPECIFIC FC MOLECULES

BISPECIFIC-FC MOLECULES

PROTEASE-ACTIVATABLE BISPECIFIC PROTEINS

Stabilized Receptor Polypeptides and Uses Thereof

V-C-FC-V-C ANTIBODY

FGF21 MUTANTS AND USES THEREOF

FGF MUTANTS AND USES THEREOF

BISPECIFIC-FC MOLECULES

Stabilized Receptor Polypeptides and Uses Thereof