Takahiro OCHIYA

Person

Tokyo, JP

People

Patents Grantslast 30 patents

Information Patent Grant
Kit, device, and method for detecting bladder cancer
- Patent number 12,234,519
- Issue date Feb 25, 2025
- Toray Industries, Inc.
- Makiko Yoshimoto
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Kit, device, and method for detecting ovarian tumor
- Patent number 12,110,557
- Issue date Oct 8, 2024
- Toray Industries, Inc.
- Yuho Kida
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Kit, device, and method for detecting lung cancer
- Patent number 12,043,872
- Issue date Jul 23, 2024
- Toray Industries, Inc.
- Yuho Kida
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method of exosome analysis, reagent for exosome analysis, and analy...
- Patent number 12,013,399
- Issue date Jun 18, 2024
- Theoria Science Inc.
- Takahiro Ochiya
- G01 - MEASURING TESTING
Information Patent Grant
Method of examining possibility of subject having pancreatic cancer
- Patent number 11,965,887
- Issue date Apr 23, 2024
- Theoria Science Inc.
- Takahiro Ochiya
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Prostate cancer detection kit or device, and detection method
- Patent number 11,959,144
- Issue date Apr 16, 2024
- Toray Industries, Inc.
- Satoshi Kondou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Kit, device and method for detecting prostate cancer
- Patent number 11,905,565
- Issue date Feb 20, 2024
- Toray Industries, Inc.
- Makiko Yoshimoto
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Breast cancer detection kit or device, and detection method
- Patent number 11,859,255
- Issue date Jan 2, 2024
- Toray Industries, Inc.
- Satoshi Kondou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Kit, device, and method for detecting bladder cancer
- Patent number 11,732,307
- Issue date Aug 22, 2023
- Toray Industries, Inc.
- Makiko Yoshimoto
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Kit, device, and method for detecting lung cancer
- Patent number 11,634,778
- Issue date Apr 25, 2023
- Toray Industries, Inc.
- Yuho Kida
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Kit, device and method for detecting prostate cancer
- Patent number 11,535,899
- Issue date Dec 27, 2022
- Toray Industries, Inc.
- Makiko Yoshimoto
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Prostate cancer detection kit or device, and detection method
- Patent number 11,519,038
- Issue date Dec 6, 2022
- Toray Industries, Inc.
- Satoshi Kondou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Breast cancer detection kit or device, and detection method
- Patent number 11,479,822
- Issue date Oct 25, 2022
- Toray Industries, Inc.
- Satoshi Kondou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method of exosome analysis, reagent for exosome analysis, and analy...
- Patent number 11,391,741
- Issue date Jul 19, 2022
- Theoria Science Inc.
- Takahiro Ochiya
- G01 - MEASURING TESTING
Information Patent Grant
MicroRNA-based methods and assays for osteocarcinoma
- Patent number 11,260,072
- Issue date Mar 1, 2022
- 3-D Matrix, Ltd.
- Takahiro Ochiya
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Kit, device, and method for detecting ovarian tumor
- Patent number 10,975,444
- Issue date Apr 13, 2021
- Toray Industries, Inc.
- Yuho Kida
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for producing hepatic stem/precursor cells from mature hepat...
- Patent number 10,961,507
- Issue date Mar 30, 2021
- Cynity Co., Ltd.
- Takahiro Ochiya
- G01 - MEASURING TESTING
Information Patent Grant
MicroRNA-based methods and assays for osteocarcinoma
- Patent number 10,905,708
- Issue date Feb 2, 2021
- Takahiro Ochiya
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Prostate cancer detection kit or device, and detection method
- Patent number 10,619,213
- Issue date Apr 14, 2020
- Toray Industries, Inc.
- Satoshi Kondou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Breast cancer detection kit or device, and detection method
- Patent number 10,597,726
- Issue date Mar 24, 2020
- Toray Industries, Inc.
- Satoshi Kondou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Genetically modified rat derived from rat embryonic stem cell
- Patent number 10,561,122
- Issue date Feb 18, 2020
- Sumitomo Chemical Company, Limited
- Takumi Teratani
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Method for diagnosing and treating cancer brain metastasis and drug...
- Patent number 10,544,466
- Issue date Jan 28, 2020
- Gene Techno Science Co., Ltd.
- Takahiro Ochiya
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method and composition for the treatment, prevention, and diagnosis...
- Patent number 10,337,012
- Issue date Jul 2, 2019
- 3-D Matrix, Ltd.
- Takahiro Ochiya
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Agent for treating cancer
- Patent number 9,790,492
- Issue date Oct 17, 2017
- National Cancer Center
- Takahiro Ochiya
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Rat embryonic stem cell
- Patent number 9,700,023
- Issue date Jul 11, 2017
- DS Pharma Biomedical Co., Ltd.
- Takumi Teratani
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
MicroRNA-based methods and assays for osteosarcoma
- Patent number 9,322,016
- Issue date Apr 26, 2016
- 3-D Matrix Ltd.
- Takahiro Ochiya
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Chimeric rat produced using rat embryonic stem cells in the presenc...
- Patent number 9,309,537
- Issue date Apr 12, 2016
- National Cancer Center
- Takahiro Ochiya
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Therapeutic agent for tumor
- Patent number 8,921,333
- Issue date Dec 30, 2014
- National Cancer Center
- Takahiro Ochiya
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method of promoting nucleic acid transfer
- Patent number 8,742,091
- Issue date Jun 3, 2014
- Dainippon Sumitomo Pharma Co., Ltd.
- Masaaki Terada
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Rat embryonic stem cell
- Patent number 8,628,957
- Issue date Jan 14, 2014
- Dainippon Sumitomo Pharma Co., Ltd.
- Takumi Teratani
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING

Patents Applicationslast 30 patents

Information Patent Application
LONG-TERM CULTURE OF COLORECTAL EPITHELIAL CELLS
- Publication number 20250027050
- Publication date Jan 23, 2025
- ISM Co., Ltd.
- Takahiro OCHIYA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING LIVER FIBROSIS
- Publication number 20240425816
- Publication date Dec 26, 2024
- Evia Life Sciences Inc.
- Takahiro Ochiya
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
KIT, DEVICE, AND METHOD FOR DETECTING OVARIAN TUMOR
- Publication number 20240425933
- Publication date Dec 26, 2024
- TORAY INDUSTRIES, INC.
- Yuho KIDA
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
COMPOSITION FOR CORONAVIRUS INFECTION INCLUDING KOJI-DERIVED EXTRAC...
- Publication number 20240398880
- Publication date Dec 5, 2024
- Da Vinci universale Co., Ltd.
- Takahiro OCHIYA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHOD FOR PRODUCING HIGHLY PROLIFERATIVE CELL, AND HIGHLY PROLIFER...
- Publication number 20240360409
- Publication date Oct 31, 2024
- TOKYO MEDICAL UNIVERSITY
- Takahiro OCHIYA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
KIT, DEVICE, AND METHOD FOR DETECTING LUNG CANCER
- Publication number 20240344146
- Publication date Oct 17, 2024
- TORAY INDUSTRIES, INC.
- Yuho KIDA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR PREDICTING DEVELOPMENT OF SEVERE SYMPTOM OF COVID-19 USI...
- Publication number 20240263234
- Publication date Aug 8, 2024
- ISM Co., Ltd.
- Mitsuru MIYATO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ISOLATION AND PURIFICATION METHOD OF EXTRACELLULAR VESICLES
- Publication number 20240238728
- Publication date Jul 18, 2024
- DAICEN MEMBRANE-SYSTEMS Ltd.
- Shuji NAKATSUKA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD
- Publication number 20240218455
- Publication date Jul 4, 2024
- TORAY INDUSTRIES, INC.
- Satoshi KONDOU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
KUMIS-DERIVED EXOSOME AND USE THEREOF
- Publication number 20240207320
- Publication date Jun 27, 2024
- Bulude EERDENG
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
KIT, DEVICE AND METHOD FOR DETECTING PROSTATE CANCER
- Publication number 20240141439
- Publication date May 2, 2024
- TORAY INDUSTRIES, INC.
- Makiko YOSHIMOTO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BREAST CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD
- Publication number 20240093311
- Publication date Mar 21, 2024
- TORAY INDUSTRIES, INC.
- Satoshi KONDOU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
KIT, DEVICE, AND METHOD FOR DETECTING BLADDER CANCER
- Publication number 20240060142
- Publication date Feb 22, 2024
- TORAY INDUSTRIES, INC.
- Makiko YOSHIMOTO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR PRODUCING MYOCARDIAL STEM/PROGENITOR CELL AND METHOD FOR...
- Publication number 20230374462
- Publication date Nov 23, 2023
- Da Vinci universale Co, Ltd.
- Asao MURANAKA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
KIT, DEVICE AND METHOD FOR DETECTING PROSTATE CANCER
- Publication number 20230212687
- Publication date Jul 6, 2023
- TORAY INDUSTRIES, INC.
- Makiko YOSHIMOTO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
KIT, DEVICE, AND METHOD FOR DETECTING LUNG CANCER
- Publication number 20230193402
- Publication date Jun 22, 2023
- TORAY INDUSTRIES, INC.
- Yuho KIDA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EXTRACELLULAR VESICLE SECRETION REDUCING AGENT FOR REDUCING EXTRACE...
- Publication number 20230151368
- Publication date May 18, 2023
- THEORIA SCIENCE INC.
- Takahiro OCHIYA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD
- Publication number 20230137844
- Publication date May 4, 2023
- TORAY INDUSTRIES, INC.
- Satoshi KONDOU
- G01 - MEASURING TESTING
Information Patent Application
BREAST CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD
- Publication number 20230091147
- Publication date Mar 23, 2023
- TORAY INDUSTRIES, INC.
- Satoshi KONDOU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD OF EXOSOME ANALYSIS, REAGENT FOR EXOSOME ANALYSIS, AND ANALY...
- Publication number 20220299517
- Publication date Sep 22, 2022
- THEORIA SCIENCE INC.
- Takahiro OCHIYA
- G01 - MEASURING TESTING
Information Patent Application
KIT, DEVICE, AND METHOD FOR DETECTING BLADDER CANCER
- Publication number 20220275449
- Publication date Sep 1, 2022
- TORAY INDUSTRIES, INC.
- Makiko YOSHIMOTO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
THERAPEUTIC DRUGS FOR FIBROSIS, INFLAMMATION, AND/OR AGING DISEASES
- Publication number 20220273725
- Publication date Sep 1, 2022
- SHANGHAI SANTEJA H&M TECH. DEVELOPMENT INC.
- Takahiro Ochiya
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
EXTRACELLULAR VESICLE COMPOSITIONS AND METHODS OF USE THEREOF
- Publication number 20220226384
- Publication date Jul 21, 2022
- Evia Life Sciences Inc.
- Kensuke Tashiro
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
microRNA Expression Promoting Agent and Food or Beverage for Promot...
- Publication number 20220170014
- Publication date Jun 2, 2022
- KEWPIE CORPORATION
- Kurataka Otsuka
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Application
THERAPEUTIC AGENT FOR FIBROSIS, INFLAMMATION, AND/OR AGING DISEASE
- Publication number 20220160786
- Publication date May 26, 2022
- INTERNATIONAL SPACE MEDICAL CO., LTD.
- Takahiro OCHIYA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
KIT, DEVICE, AND METHOD FOR DETECTING UTERINE LEIOMYOSARCOMA
- Publication number 20220136067
- Publication date May 5, 2022
- TORAY INDUSTRIES, INC.
- Makiko YOSHIMOTO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Method for Producing Stem/Precursor Cells, By Using Low Molecular W...
- Publication number 20210403874
- Publication date Dec 30, 2021
- Evia Life Sciences Inc.
- Takahiro Ochiya
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
KIT, DEVICE AND METHOD FOR DETECTING PROSTATE CANCER
- Publication number 20210310077
- Publication date Oct 7, 2021
- TORAY INDUSTRIES, INC.
- Makiko YOSHIMOTO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
KIT, DEVICE, AND METHOD FOR DETECTING OVARIAN TUMOR
- Publication number 20210230706
- Publication date Jul 29, 2021
- TORAY INDUSTRIES, INC.
- Yuho KIDA
- G01 - MEASURING TESTING
Information Patent Application
METHOD FOR ASSISTING IN DETECTION OF BREAST CANCER
- Publication number 20210079478
- Publication date Mar 18, 2021
- HIROSHIMA UNIVERSITY
- Hidetoshi TAHARA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Takahiro OCHIYA

Person

Patents Grantslast 30 patents

Kit, device, and method for detecting bladder cancer

Kit, device, and method for detecting ovarian tumor

Kit, device, and method for detecting lung cancer

Method of exosome analysis, reagent for exosome analysis, and analy...

Method of examining possibility of subject having pancreatic cancer

Prostate cancer detection kit or device, and detection method

Kit, device and method for detecting prostate cancer

Breast cancer detection kit or device, and detection method

Kit, device, and method for detecting bladder cancer

Kit, device, and method for detecting lung cancer

Kit, device and method for detecting prostate cancer

Prostate cancer detection kit or device, and detection method

Breast cancer detection kit or device, and detection method

Method of exosome analysis, reagent for exosome analysis, and analy...

MicroRNA-based methods and assays for osteocarcinoma

Kit, device, and method for detecting ovarian tumor

Method for producing hepatic stem/precursor cells from mature hepat...

MicroRNA-based methods and assays for osteocarcinoma

Prostate cancer detection kit or device, and detection method

Breast cancer detection kit or device, and detection method

Genetically modified rat derived from rat embryonic stem cell

Method for diagnosing and treating cancer brain metastasis and drug...

Method and composition for the treatment, prevention, and diagnosis...

Agent for treating cancer

Rat embryonic stem cell

MicroRNA-based methods and assays for osteosarcoma

Chimeric rat produced using rat embryonic stem cells in the presenc...

Therapeutic agent for tumor

Method of promoting nucleic acid transfer

Rat embryonic stem cell

Patents Applicationslast 30 patents

LONG-TERM CULTURE OF COLORECTAL EPITHELIAL CELLS

COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING LIVER FIBROSIS

KIT, DEVICE, AND METHOD FOR DETECTING OVARIAN TUMOR

COMPOSITION FOR CORONAVIRUS INFECTION INCLUDING KOJI-DERIVED EXTRAC...

METHOD FOR PRODUCING HIGHLY PROLIFERATIVE CELL, AND HIGHLY PROLIFER...

KIT, DEVICE, AND METHOD FOR DETECTING LUNG CANCER

METHOD FOR PREDICTING DEVELOPMENT OF SEVERE SYMPTOM OF COVID-19 USI...

ISOLATION AND PURIFICATION METHOD OF EXTRACELLULAR VESICLES

PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD

KUMIS-DERIVED EXOSOME AND USE THEREOF

KIT, DEVICE AND METHOD FOR DETECTING PROSTATE CANCER

BREAST CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD

KIT, DEVICE, AND METHOD FOR DETECTING BLADDER CANCER

METHOD FOR PRODUCING MYOCARDIAL STEM/PROGENITOR CELL AND METHOD FOR...

KIT, DEVICE AND METHOD FOR DETECTING PROSTATE CANCER

KIT, DEVICE, AND METHOD FOR DETECTING LUNG CANCER

EXTRACELLULAR VESICLE SECRETION REDUCING AGENT FOR REDUCING EXTRACE...

PROSTATE CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD

BREAST CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD

METHOD OF EXOSOME ANALYSIS, REAGENT FOR EXOSOME ANALYSIS, AND ANALY...

KIT, DEVICE, AND METHOD FOR DETECTING BLADDER CANCER

THERAPEUTIC DRUGS FOR FIBROSIS, INFLAMMATION, AND/OR AGING DISEASES

EXTRACELLULAR VESICLE COMPOSITIONS AND METHODS OF USE THEREOF

microRNA Expression Promoting Agent and Food or Beverage for Promot...

THERAPEUTIC AGENT FOR FIBROSIS, INFLAMMATION, AND/OR AGING DISEASE

KIT, DEVICE, AND METHOD FOR DETECTING UTERINE LEIOMYOSARCOMA

Method for Producing Stem/Precursor Cells, By Using Low Molecular W...

KIT, DEVICE AND METHOD FOR DETECTING PROSTATE CANCER

KIT, DEVICE, AND METHOD FOR DETECTING OVARIAN TUMOR

METHOD FOR ASSISTING IN DETECTION OF BREAST CANCER