Tinghu Zhang

Person

Brookline, MA, US

People

Patents Grantslast 30 patents

Information Patent Grant
Degraders that target proteins via KEAP1
- Patent number 12,365,677
- Issue date Jul 22, 2025
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Inhibitors of cyclin-dependent kinase 7 and uses thereof
- Patent number 12,281,126
- Issue date Apr 22, 2025
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Immunomodulatory compounds
- Patent number 12,234,220
- Issue date Feb 25, 2025
- Dana-Farber Cancer Institute, Inc.
- Nathanael Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Small molecule degraders of Helios and methods of use
- Patent number 12,227,488
- Issue date Feb 18, 2025
- Dana-Farber Cancer Institute, Inc.
- Alyssa Verano
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitors of cyclin-dependent kinase 7 (CDK7)
- Patent number 12,168,663
- Issue date Dec 17, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Ligands to cereblon (CRBN)
- Patent number 12,110,292
- Issue date Oct 8, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitors of cyclin-dependent kinases
- Patent number 12,098,154
- Issue date Sep 24, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Bispecific degraders
- Patent number 12,060,366
- Issue date Aug 13, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
CRBN modulators
- Patent number 12,030,892
- Issue date Jul 9, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitors of cyclin-dependent kinase 12 (CDK12) and uses thereof
- Patent number 11,932,625
- Issue date Mar 19, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted 6,11-dihydro-5H-benzo[b]carbazoles as inhibitors of ALK...
- Patent number 11,858,897
- Issue date Jan 2, 2024
- Dana-Farber Cancer Institute, Inc.
- John Hatcher
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Degradation of cyclin-dependent kinase 8 (CDK8) by conjugation of C...
- Patent number 11,827,636
- Issue date Nov 28, 2023
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Sulfonamide derivatives for protein degradation
- Patent number 11,807,606
- Issue date Nov 7, 2023
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Small molecule degraders of polybromo-1 (PBRM1)
- Patent number 11,771,697
- Issue date Oct 3, 2023
- Dana-Farber Cancer Institute, Inc.
- Eric Fischer
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Ligands to cereblon (CRBN)
- Patent number 11,530,219
- Issue date Dec 20, 2022
- Dana-Farber Cancer Institute, Inc.
- Nathanael Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Heterobifunctional compounds with improved specificity
- Patent number 11,505,560
- Issue date Nov 22, 2022
- Dana-Farber Cancer Institute, Inc.
- Radoslaw P. Nowak
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitors of cyclin-dependent kinases
- Patent number 11,325,910
- Issue date May 10, 2022
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitors of cyclin-dependent kinase 12 (CDK12) and uses thereof
- Patent number 11,306,070
- Issue date Apr 19, 2022
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
NEK inhibitors and methods of use
- Patent number 11,279,707
- Issue date Mar 22, 2022
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Degradation of cyclin-dependent kinase 8 (CDK8) by conjugation of C...
- Patent number 11,247,991
- Issue date Feb 15, 2022
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Pyrimido-diazepinone kinase scaffold compounds and methods for trea...
- Patent number 11,155,556
- Issue date Oct 26, 2021
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Inhibitors of mutant isocitrate dehydrogenases and compositions and...
- Patent number 11,149,032
- Issue date Oct 19, 2021
- IsoCure Biosciences Inc.
- Tinghu Zhang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitors of cyclin-dependent kinases
- Patent number 11,142,507
- Issue date Oct 12, 2021
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted 6,11-dihydro-5H-benzo[B]carbazoles as inhibitors of ALK...
- Patent number 11,066,363
- Issue date Jul 20, 2021
- Dana-Farber Cancer Institute, Inc.
- John Hatcher
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Heteroaromatic compounds useful for the treatment of proliferative...
- Patent number 11,040,957
- Issue date Jun 22, 2021
- Dana-Farber Cancer Institute, Inc.
- Stephane Ciblat
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitors of c-Jun-N-terminal kinase (JNK)
- Patent number 10,981,903
- Issue date Apr 20, 2021
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitors of interleukin-1 receptor-associated kinases and uses th...
- Patent number 10,975,055
- Issue date Apr 13, 2021
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
- Patent number 10,906,889
- Issue date Feb 2, 2021
- Dana-Farber Cancer Institute, Inc.
- Nathanael Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Salicylate inhibitors of MELK and methods of use
- Patent number 10,875,844
- Issue date Dec 29, 2020
- Dana-Farber Cancer Institute, Inc.
- Nathanael Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Inhibitors of cyclin-dependent kinase 7 (CDK7)
- Patent number 10,870,651
- Issue date Dec 22, 2020
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY

Patents Applicationslast 30 patents

Information Patent Application
DISCOVERY OF COVALENT EGFR INHIBITOR THROUGH CYSTEINE 775
- Publication number 20250221998
- Publication date Jul 10, 2025
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Compositions, Systems, and Methods for Modulating a Target Gene
- Publication number 20250127909
- Publication date Apr 24, 2025
- The Board of Trustees of the Leland Stanford Junior University
- Gerald R. Crabtree
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT
- Publication number 20250122210
- Publication date Apr 17, 2025
- Dana-Farber Cancer Institute, Inc.
- Jianwei Che
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TRICYCLIC KINASE INHIBITORS AND USES THEREOF
- Publication number 20240360132
- Publication date Oct 31, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Application
TRANSCRIPTIONAL ENHANCED ASSOCIATED DOMAIN (TEAD) TRANSCRIPTION FAC...
- Publication number 20240360104
- Publication date Oct 31, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF
- Publication number 20240352021
- Publication date Oct 24, 2024
- Dana-Farber Cancer Institute, Inc.
- JIANWEI CHE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
BIFUNCTIONAL COMPOUNDS THAT DEGRADE ALK AND USES THEREOF
- Publication number 20240336643
- Publication date Oct 10, 2024
- Dana-Farber Cancer Institute, Inc.
- Baishan Jiang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
INHIBITORS AND DEGRADERS OF PIP4K PROTEIN
- Publication number 20240277852
- Publication date Aug 22, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SMALL MOLECULE DEGRADERS OF PHOSPHATIDYLINOSITOL-5-PHOSPHATE 4-KINA...
- Publication number 20240245786
- Publication date Jul 25, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Application
PHTHALIMIDO CEREBLON COMPLEX BINDERS AND TRANSCRIPTION FACTOR DEGRA...
- Publication number 20240217970
- Publication date Jul 4, 2024
- Dana-Farber Cancer Institute, Inc.
- Tinghu Zhang
- C07 - ORGANIC CHEMISTRY
Information Patent Application
INHIBITORS OF THE PEPTIDYL-PROLYL CIS/TRANS ISOMERASE (PIN1) AND US...
- Publication number 20240197678
- Publication date Jun 20, 2024
- Dana-Farber Cancer Institute, Inc.
- Inchul You
- C07 - ORGANIC CHEMISTRY
Information Patent Application
COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF
- Publication number 20240166665
- Publication date May 23, 2024
- Dana-Farber Cancer Institute, Inc.
- NATHANAEL S. GRAY
- C07 - ORGANIC CHEMISTRY
Information Patent Application
INHIBITORS OF TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) AND...
- Publication number 20240124406
- Publication date Apr 18, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PRPK INHIBITORS
- Publication number 20240124459
- Publication date Apr 18, 2024
- Dana-Farber Cancer Institute, Inc.
- Kenneth C. Anderson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TRICYCLIC KINASE INHIBITORS AND USES THEREOF
- Publication number 20240101559
- Publication date Mar 28, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Application
COMPOUNDS FOR TAU PROTEIN DEGRADATION
- Publication number 20240091213
- Publication date Mar 21, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SULFONAMIDE DERIVATIVES FOR PROTEIN DEGRADATION
- Publication number 20240083847
- Publication date Mar 14, 2024
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Application
PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE
- Publication number 20240034723
- Publication date Feb 1, 2024
- Dana-Farber Cancer Institute, Inc.
- Hu Liu
- C07 - ORGANIC CHEMISTRY
Information Patent Application
COVALENT INHIBITORS OF CREATINE KINASE (CK) AND USES THEREOF FOR TR...
- Publication number 20230399304
- Publication date Dec 14, 2023
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Application
IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS...
- Publication number 20230391768
- Publication date Dec 7, 2023
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SELECTIVE SMALL MOLECULE DEGRADERS OF CEREBLON
- Publication number 20230357222
- Publication date Nov 9, 2023
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF
- Publication number 20230339922
- Publication date Oct 26, 2023
- Dana-Farber Cancer Institute, Inc.
- NATHANAEL S. GRAY
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
LIGANDS TO CEREBLON (CRBN)
- Publication number 20230312575
- Publication date Oct 5, 2023
- Dana-Farber Cancer Institute, Inc.
- Nathanael Gray
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Modulation of Gene Expression Via Transcription Factor-Chemically I...
- Publication number 20230304024
- Publication date Sep 28, 2023
- The Board of Trustees of the Leland Stanford Junior University
- Gerald R. Crabtree
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF
- Publication number 20230295137
- Publication date Sep 21, 2023
- Dana-Farber Cancer Institute, Inc.
- ZHENGNIAN LI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SMALL MOLECULE COVALENT ACTIVATORS OF UCP1
- Publication number 20230271932
- Publication date Aug 31, 2023
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PRPK INHIBITORS
- Publication number 20230271966
- Publication date Aug 31, 2023
- Dana-Farber Cancer Institute, Inc.
- Kenneth C. Anderson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 AND USES THEREOF
- Publication number 20230242534
- Publication date Aug 3, 2023
- Dana-Farber Cancer Institute, Inc.
- Tinghu Zhang
- C07 - ORGANIC CHEMISTRY
Information Patent Application
TARGETED ABERRANT ALPHA-SYNUCLEIN SPECIES AND INDUCED UBIQUITINATIO...
- Publication number 20230226195
- Publication date Jul 20, 2023
- Dana-Farber Cancer Institute, Inc.
- Fleur M. Ferguson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
INHIBITORS OF CYCLIN-DEPENDENT KINASE 12 (CDK12) AND USES THEREOF
- Publication number 20230227433
- Publication date Jul 20, 2023
- Dana-Farber Cancer Institute, Inc.
- Nathanael S. Gray
- C07 - ORGANIC CHEMISTRY

Tinghu Zhang

Person

Patents Grantslast 30 patents

Degraders that target proteins via KEAP1

Inhibitors of cyclin-dependent kinase 7 and uses thereof

Immunomodulatory compounds

Small molecule degraders of Helios and methods of use

Inhibitors of cyclin-dependent kinase 7 (CDK7)

Ligands to cereblon (CRBN)

Inhibitors of cyclin-dependent kinases

Bispecific degraders

CRBN modulators

Inhibitors of cyclin-dependent kinase 12 (CDK12) and uses thereof

Substituted 6,11-dihydro-5H-benzo[b]carbazoles as inhibitors of ALK...

Degradation of cyclin-dependent kinase 8 (CDK8) by conjugation of C...

Sulfonamide derivatives for protein degradation

Small molecule degraders of polybromo-1 (PBRM1)

Ligands to cereblon (CRBN)

Heterobifunctional compounds with improved specificity

Inhibitors of cyclin-dependent kinases

Inhibitors of cyclin-dependent kinase 12 (CDK12) and uses thereof

NEK inhibitors and methods of use

Degradation of cyclin-dependent kinase 8 (CDK8) by conjugation of C...

Pyrimido-diazepinone kinase scaffold compounds and methods for trea...

Inhibitors of mutant isocitrate dehydrogenases and compositions and...

Inhibitors of cyclin-dependent kinases

Substituted 6,11-dihydro-5H-benzo[B]carbazoles as inhibitors of ALK...

Heteroaromatic compounds useful for the treatment of proliferative...

Inhibitors of c-Jun-N-terminal kinase (JNK)

Inhibitors of interleukin-1 receptor-associated kinases and uses th...

Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)

Salicylate inhibitors of MELK and methods of use

Inhibitors of cyclin-dependent kinase 7 (CDK7)

Patents Applicationslast 30 patents

DISCOVERY OF COVALENT EGFR INHIBITOR THROUGH CYSTEINE 775

Compositions, Systems, and Methods for Modulating a Target Gene

SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT

TRICYCLIC KINASE INHIBITORS AND USES THEREOF

TRANSCRIPTIONAL ENHANCED ASSOCIATED DOMAIN (TEAD) TRANSCRIPTION FAC...

COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF

BIFUNCTIONAL COMPOUNDS THAT DEGRADE ALK AND USES THEREOF

INHIBITORS AND DEGRADERS OF PIP4K PROTEIN

SMALL MOLECULE DEGRADERS OF PHOSPHATIDYLINOSITOL-5-PHOSPHATE 4-KINA...

PHTHALIMIDO CEREBLON COMPLEX BINDERS AND TRANSCRIPTION FACTOR DEGRA...

INHIBITORS OF THE PEPTIDYL-PROLYL CIS/TRANS ISOMERASE (PIN1) AND US...

COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF

INHIBITORS OF TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) AND...

PRPK INHIBITORS

TRICYCLIC KINASE INHIBITORS AND USES THEREOF

COMPOUNDS FOR TAU PROTEIN DEGRADATION

SULFONAMIDE DERIVATIVES FOR PROTEIN DEGRADATION

PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE

COVALENT INHIBITORS OF CREATINE KINASE (CK) AND USES THEREOF FOR TR...

IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS...

SELECTIVE SMALL MOLECULE DEGRADERS OF CEREBLON

COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF

LIGANDS TO CEREBLON (CRBN)

Modulation of Gene Expression Via Transcription Factor-Chemically I...

COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF

SMALL MOLECULE COVALENT ACTIVATORS OF UCP1

PRPK INHIBITORS

INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 AND USES THEREOF

TARGETED ABERRANT ALPHA-SYNUCLEIN SPECIES AND INDUCED UBIQUITINATIO...

INHIBITORS OF CYCLIN-DEPENDENT KINASE 12 (CDK12) AND USES THEREOF