Yongxin Han

Person

Needham, MA, US

People

Patents Grantslast 30 patents

Information Patent Grant
Substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxyge...
- Patent number 12,157,727
- Issue date Dec 3, 2024
- Merck Sharp & Dohme LLC
- Yongxin Han
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Arylalkyl pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors
- Patent number 12,152,019
- Issue date Nov 26, 2024
- Merck Sharp & Dohme LLC
- Dane Clausen
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted pyrazole compounds as indoleamine 2,3-dioxygenase inhib...
- Patent number 12,091,405
- Issue date Sep 17, 2024
- Merck Sharp & Dohme LLC
- Dane Clausen
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted tricyclic compounds as indoleamine 2,3-dioxygenase inhi...
- Patent number 12,065,438
- Issue date Aug 20, 2024
- Merck Sharp & Dohme LLC
- Yongxin Han
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted tetrahydroquinoline compounds as indoleamine 2,3-dioxyg...
- Patent number 11,992,489
- Issue date May 28, 2024
- Merck Sharp & Dohme LLC
- Dane Clausen
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Small molecule inhibitors of KRAS G12C mutant
- Patent number 11,697,657
- Issue date Jul 11, 2023
- Merck Sharp & Dohme LLC
- Indu Bharathan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Aryl and heteroaryl ether derivatives as liver X receptor beta agon...
- Patent number 11,655,216
- Issue date May 23, 2023
- Merck Sharp & Dohme LLC
- Michael T. Rudd
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) i...
- Patent number 11,498,904
- Issue date Nov 15, 2022
- Merck Sharp & Dohme LLC
- Yongxin Han
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
[1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors
- Patent number 11,478,461
- Issue date Oct 25, 2022
- Merck Sharp & Dohme LLC
- Liangqin Guo
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenas...
- Patent number 11,352,320
- Issue date Jun 7, 2022
- Merck Sharp & Dohme Corp.
- Shuwen He
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted phenyloxetane and phenyltetrahydrofuran compounds as in...
- Patent number 11,319,295
- Issue date May 3, 2022
- Merck Sharp & Dohme Corp.
- Catherine M. White
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted cyclobutylbenzene compounds as indoleamine 2,3-dioxygen...
- Patent number 11,319,283
- Issue date May 3, 2022
- Merck Sharp & Dohme Corp.
- Meredeth Ann McGowan
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
[3.3.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors
- Patent number 11,267,786
- Issue date Mar 8, 2022
- Merck Sharp & Dohme Corp.
- Shuwen He
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted phenyl compounds as indoleamine 2,3-dioxygenase (IDO) i...
- Patent number 11,208,407
- Issue date Dec 28, 2021
- Merck Sharp & Dohme Corp.
- Hua Zhou
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted cyclobutylpyridine and cyclobutylpyrimidine compounds a...
- Patent number 11,111,232
- Issue date Sep 7, 2021
- Merck Sharp & Dohme Corp.
- Catherine M. White
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted pyridinyl compounds as indoleamine 2,3-dioxygenase (IDO...
- Patent number 11,103,493
- Issue date Aug 31, 2021
- Merck Sharp & Dohme Corp.
- Hua Zhou
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted imidazopyridine compounds as inhibitors of indoleamine...
- Patent number 11,096,930
- Issue date Aug 24, 2021
- Merck Sharp & Dohme Corp.
- Phillip M. Cowley
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted N′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as i...
- Patent number 11,034,661
- Issue date Jun 15, 2021
- Merck Sharp & Dohme Corp.
- Liangqin Guo
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) i...
- Patent number 10,995,085
- Issue date May 4, 2021
- Merck Sharp & Dohme Corp.
- Yongxin Han
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted n′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as i...
- Patent number 10,988,487
- Issue date Apr 27, 2021
- Merck Sharp & Dohme Corp.
- Kun Liu
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
N-aryl and N-heteroaryl piperidine derivatives as liver X receptor...
- Patent number 10,961,215
- Issue date Mar 30, 2021
- Merck Sharp & Dohme Corp.
- Michael T. Rudd
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (I...
- Patent number 10,927,086
- Issue date Feb 23, 2021
- Merck Sharp & Dohme Corp.
- Kun Liu
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Piperidine derivatives as liver X receptor beta agonists, compositi...
- Patent number 10,894,775
- Issue date Jan 19, 2021
- Merck Sharp & Dohme Corp.
- Michael T. Rudd
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) i...
- Patent number 10,647,705
- Issue date May 12, 2020
- Merck Sharp & Dohme Corp.
- Yongxin Han
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Compounds as indoleamine 2,3-dioxygenase inhibitors
- Patent number 10,538,497
- Issue date Jan 21, 2020
- Merck Sharp & Dohme Corp.
- Yongxin Han
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted bicyclic fused ring compounds as indoleamine-2,3-dioxyg...
- Patent number 10,501,458
- Issue date Dec 10, 2019
- Iomet Pharma Ltd.
- Phillip M. Cowley
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Aryl sulfonamides as BLT1 antagonists
- Patent number 10,450,309
- Issue date Oct 22, 2019
- Merch Sharp & Dohme Corp.
- Yongxin Han
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Aryl acylsulfonamides as BLT1 antagonists
- Patent number 10,370,368
- Issue date Aug 6, 2019
- Merck Sharp & Dohme Corp.
- Yongxin Han
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted 1H-indole-2-carboxamide compounds as indoleamine-2,3-di...
- Patent number 10,336,731
- Issue date Jul 2, 2019
- Merck Sharp & Dohme Corp.
- Phillip M. Cowley
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Aryl acylsulfonamides as BLT1 antagonists
- Patent number 10,336,733
- Issue date Jul 2, 2019
- Merk Sharp & Dohme Corp.
- Yongxin Han
- C07 - ORGANIC CHEMISTRY

Patents Applicationslast 30 patents

Information Patent Application
SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT
- Publication number 20240262842
- Publication date Aug 8, 2024
- Merck Sharp & Dohme LLC
- Kazuaki SHIBATA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT
- Publication number 20240246968
- Publication date Jul 25, 2024
- Merck Sharp & Dohme LLC
- Kazuaki SHIBATA
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT
- Publication number 20240239788
- Publication date Jul 18, 2024
- Merck Sharp & Dohme LLC
- David L. Sloman
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SPIROCYCLIC-SUBSTITUTED 6,7-DIHYDRO-PYRANO[2,3-d]PYRIMIDINE INHIBIT...
- Publication number 20240124478
- Publication date Apr 18, 2024
- Merck Sharp & Dohme LLC
- Yongxin Han
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Small Molecule Inhibitors of KRAS G12C Mutant
- Publication number 20240083913
- Publication date Mar 14, 2024
- Merck Sharp & Dohme LLC
- Indu Bharathan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Small Molecule Inhibitors of KRAS G12C Mutant
- Publication number 20240043448
- Publication date Feb 8, 2024
- Merck Sharp & Dohme LLC
- Indu Bharathan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
6,7-DIHYDRO-PYRANO[2,3-d]PYRIMIDINE INHIBITORS OF KRAS G12C MUTANT
- Publication number 20230416266
- Publication date Dec 28, 2023
- MERCK SHARP & DOHME CORP.
- Yongxin Han
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIO...
- Publication number 20230008022
- Publication date Jan 12, 2023
- MERCK SHARP & DOHME CORP.
- Dane Clausen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT
- Publication number 20220402916
- Publication date Dec 22, 2022
- MERCK SHARP & DOHME CORP.
- Andrew J. Hoover
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL SUBSTITUTED 1,3-8-TRIAZASPIRO[4,5] DECANE-2,4-DIONE COMPOUNDS...
- Publication number 20220396577
- Publication date Dec 15, 2022
- Merck Sharp & Dohme LLC
- Yongxin Han
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ARYL SULFONAMIDES AS BLT1 ANTAGONISTS
- Publication number 20220363656
- Publication date Nov 17, 2022
- MERCK SHARP & DOHME CORP.
- Yongxin Han
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-D...
- Publication number 20220235028
- Publication date Jul 28, 2022
- MERCK SHARP & DOHME CORP.
- Yongxin Han
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NOVEL SUBSTITUTED TRICYCLIC COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENAS...
- Publication number 20210403469
- Publication date Dec 30, 2021
- MERCK SHARP & DOHME CORP.
- Yongxin Han
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhi...
- Publication number 20210393600
- Publication date Dec 23, 2021
- MERCK SHARP & DOHME CORP.
- Liangqin Guo
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL SUBSTITUTED PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE...
- Publication number 20210395240
- Publication date Dec 23, 2021
- MERCK SHARP & DOHME CORP.
- Dane Clausen
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NOVEL ARYLALKYL PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE I...
- Publication number 20210380572
- Publication date Dec 9, 2021
- MERCK SHARP & DOHME CORP.
- Dane Clausen
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXY...
- Publication number 20210330676
- Publication date Oct 28, 2021
- MERCK SHARP & DOHME CORP.
- Dane Clausen
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NOVEL SUBSTITUTED BIARYL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (...
- Publication number 20210317091
- Publication date Oct 14, 2021
- MERCK SHARP & DOHME CORP.
- Yongxin Han
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL [3.3.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHI...
- Publication number 20210214308
- Publication date Jul 15, 2021
- MERCK SHARP & DOHME CORP.
- Shuwen He
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL SUBSTITUTED [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOX...
- Publication number 20210198190
- Publication date Jul 1, 2021
- MERCK SHARP & DOHME CORP.
- Shuwen He
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-D...
- Publication number 20210179607
- Publication date Jun 17, 2021
- MERCK SHARP & DOHME CORP.
- Yongqi Deng
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NOVEL SUBSTITUTED TETRAHYDROQUINOLINE COMPOUNDS AS INDOLEAMINE 2,3-...
- Publication number 20210161896
- Publication date Jun 3, 2021
- MERCK SHARP & DOHME CORP.
- Dane Clausen
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Small Molecule Inhibitors of KRAS G12C Mutant
- Publication number 20210122764
- Publication date Apr 29, 2021
- MERCK SHARP & DOHME CORP.
- Indu Bharathan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL SUBSTITUTED CYCLOBUTYLPYRIDINE AND CYCLOBUTYLPYRIMIDINE COMPO...
- Publication number 20200290996
- Publication date Sep 17, 2020
- MERCK SHARP & DOHME CORP.
- Catherine M. White
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NOVEL SUBSTITUTED CYCLOBUTYLBENZENE COMPOUNDS AS INDOLEAMINE 2,3-DI...
- Publication number 20200277252
- Publication date Sep 3, 2020
- MERCK SHARP & DOHME CORP.
- Meredeth Ann McGowan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGON...
- Publication number 20200247754
- Publication date Aug 6, 2020
- MERCK SHARP & DOHME CORP.
- Michael T. Rudd
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NOVEL SUBSTITUTED PHENYLOXETANE AND PHENYLTETRAHYDROFURAN COMPOUND...
- Publication number 20200239423
- Publication date Jul 30, 2020
- MERCK SHARP & DOHME CORP.
- Catherine M. White
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL SUBSTITUTED N'-HYDROXYCARBAMIMIDOYL-1,2,5-OXADIAZOLE COMPOUND...
- Publication number 20200231606
- Publication date Jul 23, 2020
- MERCK SHARP & DOHME CORP.
- Kun Liu
- C07 - ORGANIC CHEMISTRY
Information Patent Application
NOVEL SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS AS INHIBITORS OF INDOLE...
- Publication number 20200230117
- Publication date Jul 23, 2020
- IOMet Pharma Ltd.
- Phillip M. Cowley
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL SUBSTITUTED PHENYL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (...
- Publication number 20200216443
- Publication date Jul 9, 2020
- MERCK SHARP & DOHME CORP.
- Hua Zhou
- C07 - ORGANIC CHEMISTRY

Yongxin Han

Person

Patents Grantslast 30 patents

Substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxyge...

Arylalkyl pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors

Substituted pyrazole compounds as indoleamine 2,3-dioxygenase inhib...

Substituted tricyclic compounds as indoleamine 2,3-dioxygenase inhi...

Substituted tetrahydroquinoline compounds as indoleamine 2,3-dioxyg...

Small molecule inhibitors of KRAS G12C mutant

Aryl and heteroaryl ether derivatives as liver X receptor beta agon...

Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) i...

[1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors

Substituted [1.1.1] bicyclo compounds as indoleamine 2,3-dioxygenas...

Substituted phenyloxetane and phenyltetrahydrofuran compounds as in...

Substituted cyclobutylbenzene compounds as indoleamine 2,3-dioxygen...

[3.3.1] bicyclo compounds as indoleamine 2,3-dioxygenase inhibitors

Substituted phenyl compounds as indoleamine 2,3-dioxygenase (IDO) i...

Substituted cyclobutylpyridine and cyclobutylpyrimidine compounds a...

Substituted pyridinyl compounds as indoleamine 2,3-dioxygenase (IDO...

Substituted imidazopyridine compounds as inhibitors of indoleamine...

Substituted N′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as i...

Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) i...

Substituted n′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as i...

N-aryl and N-heteroaryl piperidine derivatives as liver X receptor...

Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (I...

Piperidine derivatives as liver X receptor beta agonists, compositi...

Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) i...

Compounds as indoleamine 2,3-dioxygenase inhibitors

Substituted bicyclic fused ring compounds as indoleamine-2,3-dioxyg...

Aryl sulfonamides as BLT1 antagonists

Aryl acylsulfonamides as BLT1 antagonists

Substituted 1H-indole-2-carboxamide compounds as indoleamine-2,3-di...

Aryl acylsulfonamides as BLT1 antagonists

Patents Applicationslast 30 patents

SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT

SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT

SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT

SPIROCYCLIC-SUBSTITUTED 6,7-DIHYDRO-PYRANO[2,3-d]PYRIMIDINE INHIBIT...

Small Molecule Inhibitors of KRAS G12C Mutant

Small Molecule Inhibitors of KRAS G12C Mutant

6,7-DIHYDRO-PYRANO[2,3-d]PYRIMIDINE INHIBITORS OF KRAS G12C MUTANT

NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIO...

SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT

NOVEL SUBSTITUTED 1,3-8-TRIAZASPIRO[4,5] DECANE-2,4-DIONE COMPOUNDS...

ARYL SULFONAMIDES AS BLT1 ANTAGONISTS

NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-D...

NOVEL SUBSTITUTED TRICYCLIC COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENAS...

Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhi...

NOVEL SUBSTITUTED PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE...

NOVEL ARYLALKYL PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE I...

NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXY...

NOVEL SUBSTITUTED BIARYL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (...

NOVEL [3.3.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHI...

NOVEL SUBSTITUTED [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOX...

NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-D...

NOVEL SUBSTITUTED TETRAHYDROQUINOLINE COMPOUNDS AS INDOLEAMINE 2,3-...

Small Molecule Inhibitors of KRAS G12C Mutant

NOVEL SUBSTITUTED CYCLOBUTYLPYRIDINE AND CYCLOBUTYLPYRIMIDINE COMPO...

NOVEL SUBSTITUTED CYCLOBUTYLBENZENE COMPOUNDS AS INDOLEAMINE 2,3-DI...

ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGON...

NOVEL SUBSTITUTED PHENYLOXETANE AND PHENYLTETRAHYDROFURAN COMPOUND...

NOVEL SUBSTITUTED N'-HYDROXYCARBAMIMIDOYL-1,2,5-OXADIAZOLE COMPOUND...

NOVEL SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS AS INHIBITORS OF INDOLE...

NOVEL SUBSTITUTED PHENYL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (...