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CCHEMISTRY METALLURGY C12Biochemistry C12NMICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA C12N2502/00Coculture with Conditioned medium produced by

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C12N2502/1107B cells

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Patents Grantslast 30 patents

Information Patent Grant
Method for activating T cells for cancer treatment
- Patent number 11,969,463
- Issue date Apr 30, 2024
- Good T Cells, Inc.
- Jung Ho Kim
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
B-cell cultivation method
- Patent number 11,952,586
- Issue date Apr 9, 2024
- HOFFMANN-LA ROCHE INC.
- Sonja Offner
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for activating T cells for cancer treatment
- Patent number 11,918,634
- Issue date Mar 5, 2024
- Good T Cells, Inc.
- Jung Ho Kim
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Generation of HPV-specific T-cells
- Patent number 11,590,218
- Issue date Feb 28, 2023
- Baylor College of Medicine
- Carlos A. Ramos
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Pharmaceutical composition and methods comprising immune cells and...
- Patent number 11,504,396
- Issue date Nov 22, 2022
- NKMAX CO., LTD.
- Tae-gyun Kim
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
In vitro neonatal biomimetic (nMIMIC) model and methods of using same
- Patent number 11,156,601
- Issue date Oct 26, 2021
- Sanofi Pasteur Vaxdesign Corporation
- Evan Gomes
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Antigen-specific T cells for inducing immune tolerance
- Patent number 11,090,373
- Issue date Aug 17, 2021
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- David W. Scott
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Human CD8+ regulatory T cells inhibit GVHD and preserve general imm...
- Patent number 10,653,722
- Issue date May 19, 2020
- The University of Hong Kong
- Wenwei Tu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Generation of HPV-specific T-cells
- Patent number 10,500,265
- Issue date Dec 10, 2019
- Baylor College of Medicine
- Carlos A. Ramos
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Human CD8+ regulatory T cells inhibit GVHD and preserve general imm...
- Patent number 10,092,597
- Issue date Oct 9, 2018
- The University of Hong Kong
- Wenwei Tu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
T cell expansion
- Patent number 10,052,372
- Issue date Aug 21, 2018
- TESSA THERAPEUTICS PTE LTD
- Peter Wang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Expansion of alloantigen-reactive regulatory T cells
- Patent number 9,801,911
- Issue date Oct 31, 2017
- The Regents of the University of California
- Qizhi Tang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Regulatory B cells (tBREGS) and their use
- Patent number 9,657,269
- Issue date May 23, 2017
- The United States of America, as represented by the Secretary, Department of...
- Bira Arya
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Artificial immune system: methods of use
- Patent number 9,625,444
- Issue date Apr 18, 2017
- Sanofi Pasteur Vaxdesign Corporation
- William L Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for testing an immune response using cultures of T cells, B...
- Patent number 8,962,319
- Issue date Feb 24, 2015
- Sanofi Pasteur Vaxdesign Corp.
- William L. Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Artificial immune system: methods of use
- Patent number 8,722,402
- Issue date May 13, 2014
- Sanofi Pasteur Vaxdesign Corporation
- William L Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for testing an immune response using cultures of T cells, B...
- Patent number 8,697,371
- Issue date Apr 15, 2014
- Sanofi Pasteur Vaxdesign Corp.
- William L. Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for assaying responses to vaccines
- Patent number 8,669,105
- Issue date Mar 11, 2014
- Sanofi Pasteur Vaxdesign Corp.
- Selva Sukumar
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Methods for antibody production
- Patent number 8,298,823
- Issue date Oct 30, 2012
- Sanofi Pasteur Vaxdesign Corporation
- William L. Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Artificial immune system: methods for making and use
- Patent number 8,288,159
- Issue date Oct 16, 2012
- Sanofi Pasteur Vaxdesign Corp. et al.
- William L Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods of evaluating an immune response to an antigen
- Patent number 8,247,226
- Issue date Aug 21, 2012
- Sanofi Pasteur Vaxdesign Corp.
- Selva Sukumar
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Method for determining the immunogenicity of an antigen
- Patent number 8,080,416
- Issue date Dec 20, 2011
- Sanofi Pasteur Vaxdesign Corp.
- William L. Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Co-culture lymphoid tissue equivalent (LTE) for an artificial immun...
- Patent number 8,071,373
- Issue date Dec 6, 2011
- Sanofi Pasteur Vaxdesign Corp.
- William L. Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Artificial lymphoid tissue equivalent
- Patent number 8,030,070
- Issue date Oct 4, 2011
- Sanofi Pasteur Vaxdesign Corp.
- Guzman Sanchez-Schmitz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
In vitro germinal centers
- Patent number 8,003,385
- Issue date Aug 23, 2011
- Sanofi Pasteur Vax Design Corp.
- Selva Sukumar
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
In vitro germinal centers
- Patent number 8,003,387
- Issue date Aug 23, 2011
- Sanofi Pasteur Vaxdesign Corp.
- Selva Sukumar
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Artificial immune system: methods for making and use
- Patent number 7,855,074
- Issue date Dec 21, 2010
- Vaxdesign Corp.
- William L. Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for determining the immunogenicity of an antigen
- Patent number 7,785,806
- Issue date Aug 31, 2010
- Vaxdesign Corporation
- William L. Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Automatable artificial immune system (AIS)
- Patent number 7,785,883
- Issue date Aug 31, 2010
- Vax Design Corp.
- William L. Warren
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY
- Publication number 20240408200
- Publication date Dec 12, 2024
- WILSON WOLF MANUFACTURING
- Juan F. Vera
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND...
- Publication number 20240392245
- Publication date Nov 28, 2024
- Iovance Biotherapeutics, Inc.
- Lavakumar Karyampudi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SINGLE VESSEL EXPANSION OF LYMPHOCYTES
- Publication number 20240287454
- Publication date Aug 29, 2024
- TIGEN PHARMA SA
- George Coukos
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
A METHOD FOR PRODUCING ANTIGEN-SPECIFIC T CELLS
- Publication number 20240287456
- Publication date Aug 29, 2024
- Achilles Therapeutics UK Limited
- Katy Rebecca Newton
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHOD FOR ACTIVATING T CELLS FOR CANCER TREATMENT
- Publication number 20240156927
- Publication date May 16, 2024
- GOOD T CELLS, INC.
- Jung Ho KIM
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY
- Publication number 20240002797
- Publication date Jan 4, 2024
- WILSON WOLF MANUFACTURING
- Juan F. Vera
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
HLA CLASS II-RESTRICTED TCRS AGAINST THE KRAS G12>V ACTIVATING MUTA...
- Publication number 20230399402
- Publication date Dec 14, 2023
- LA JOLLA INSTITUTE FOR IMMUNOLOGY
- Stephen P. Schoenberger
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY
- Publication number 20230383250
- Publication date Nov 30, 2023
- WILSON WOLF MANUFACTURING
- Juan F. Vera
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
EX VIVO EXPANSION OF REGULATORY T CELLS FOR SUPPRESSION OF GRAFT VE...
- Publication number 20230346936
- Publication date Nov 2, 2023
- CITY OF HOPE
- Fouad Kandeel
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood
- Publication number 20230340412
- Publication date Oct 26, 2023
- Iovance Biotherapeutics, Inc.
- Lavakumar Karyampudi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND...
- Publication number 20230092130
- Publication date Mar 23, 2023
- Iovance Biotherapeutics, Inc.
- Lavakumar Karyampudi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Method for Transduction of T Cells in the Presence of Malignant Cells
- Publication number 20220315894
- Publication date Oct 6, 2022
- Miltenyi Biotec B.V. & Co. KG
- Nicole Cordes
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
EXPANSION OF NATURAL KILLER AND CHIMERIC ANTIGEN RECEPTOR-MODIFIED...
- Publication number 20220152102
- Publication date May 19, 2022
- Rutgers, The State University of New Jersey
- Dongfang Liu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PHARMACEUTICAL PREPARATION COMPRISING SUPERNATANT OF BLOOD MONONUCL...
- Publication number 20220118020
- Publication date Apr 21, 2022
- Aposcience AG
- Hendrik Jan Ankersmit
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RAPID AND EFFICIENT METHOD FOR EXPANDING HUMAN MESENCHYMAL STEM CEL...
- Publication number 20220056416
- Publication date Feb 24, 2022
- Affiliated Hospital of Zunyi Medical University
- Jianhui Xiao
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTIGEN-SPECIFIC T CELLS FOR INDUCING IMMUNE TOLERANCE
- Publication number 20220054608
- Publication date Feb 24, 2022
- The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
- David W. SCOTT
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IN VITRO PRODUCTION OF HIGH AFFINITY MONOCLONAL ANTIBODIES
- Publication number 20220002670
- Publication date Jan 6, 2022
- CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
- Ana MARTINEZ RIAÑO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PRODUCTION OF A BIOENGINEERED LUNG
- Publication number 20210155904
- Publication date May 27, 2021
- The Board of Regents of the University of Texas System
- Joaquin CORTIELLA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR ACTIVATING T CELLS FOR CANCER TREATMENT
- Publication number 20210009952
- Publication date Jan 14, 2021
- GOOD T CELLS, INC.
- Jung Ho KIM
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
B-CELL CULTIVATION METHOD
- Publication number 20200399596
- Publication date Dec 24, 2020
- HOFFMANN-LA ROCHE INC.
- Sonja Offner
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood
- Publication number 20200347350
- Publication date Nov 5, 2020
- Iovance Biotherapeutics, Inc.
- Lavakumar Karyampudi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR EXPANSION OF LYMPHOCYTES
- Publication number 20200338125
- Publication date Oct 29, 2020
- LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.
- Sara BOBISSE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND...
- Publication number 20200224161
- Publication date Jul 16, 2020
- Iovance Biotherapeutics, Inc.
- Lavakumar Karyampudi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS FOR GENERATING POLYCLONAL REGULATORY T CELLS
- Publication number 20200179449
- Publication date Jun 11, 2020
- THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Megan Sykes
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TREATMENT OF LIVER FAILURE WITH ACTIVATED T REGULATORY CELLS
- Publication number 20200171088
- Publication date Jun 4, 2020
- Viera Bioscience, Inc.
- Thomas E. Ichim
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
B-cell cultivation method
- Publication number 20200149006
- Publication date May 14, 2020
- HOFFMANN-LA ROCHE INC.
- Friederike JUNG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
REGULATORY B CELLS AND USES THEREOF
- Publication number 20200113939
- Publication date Apr 16, 2020
- Board of Regents, The University of Texas System
- Katy REZVANI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CULTURE MEDIA FOR SIMULTANEOUS TESTING OF MULTIPLE HEMATOPOIETIC DI...
- Publication number 20190382727
- Publication date Dec 19, 2019
- Precipio, Inc.
- Ayman MOHAMED
- G01 - MEASURING TESTING
Information Patent Application
IN VITRO NEONATAL BIOMIMETIC (NMIMIC) MODEL AND METHODS OF USING SAME
- Publication number 20190187127
- Publication date Jun 20, 2019
- SANOFI PASTEUR VAXDESIGN CORPORATION
- Evan GOMES
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TRANSFECTION OF DENDRITIC CELLS AND METHODS THEREFOR
- Publication number 20190167722
- Publication date Jun 6, 2019
- Nant Holdings IP, LLC
- Patrick Soon-Shiong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Method for activating T cells for cancer treatment

B-cell cultivation method

Method for activating T cells for cancer treatment

Generation of HPV-specific T-cells

Pharmaceutical composition and methods comprising immune cells and...

In vitro neonatal biomimetic (nMIMIC) model and methods of using same

Antigen-specific T cells for inducing immune tolerance

Human CD8+ regulatory T cells inhibit GVHD and preserve general imm...

Generation of HPV-specific T-cells

Human CD8+ regulatory T cells inhibit GVHD and preserve general imm...

T cell expansion

Expansion of alloantigen-reactive regulatory T cells

Regulatory B cells (tBREGS) and their use

Artificial immune system: methods of use

Methods for testing an immune response using cultures of T cells, B...

Artificial immune system: methods of use

Methods for testing an immune response using cultures of T cells, B...

Methods for assaying responses to vaccines

Methods for antibody production

Artificial immune system: methods for making and use

Methods of evaluating an immune response to an antigen

Method for determining the immunogenicity of an antigen

Co-culture lymphoid tissue equivalent (LTE) for an artificial immun...

Artificial lymphoid tissue equivalent

In vitro germinal centers

In vitro germinal centers

Artificial immune system: methods for making and use

Method for determining the immunogenicity of an antigen

Automatable artificial immune system (AIS)

Patents Applicationslast 30 patents

METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY

EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND...

SINGLE VESSEL EXPANSION OF LYMPHOCYTES

A METHOD FOR PRODUCING ANTIGEN-SPECIFIC T CELLS

METHOD FOR ACTIVATING T CELLS FOR CANCER TREATMENT

METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY

HLA CLASS II-RESTRICTED TCRS AGAINST THE KRAS G12>V ACTIVATING MUTA...

METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY

EX VIVO EXPANSION OF REGULATORY T CELLS FOR SUPPRESSION OF GRAFT VE...

Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood

EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND...

Method for Transduction of T Cells in the Presence of Malignant Cells

EXPANSION OF NATURAL KILLER AND CHIMERIC ANTIGEN RECEPTOR-MODIFIED...

PHARMACEUTICAL PREPARATION COMPRISING SUPERNATANT OF BLOOD MONONUCL...

RAPID AND EFFICIENT METHOD FOR EXPANDING HUMAN MESENCHYMAL STEM CEL...

ANTIGEN-SPECIFIC T CELLS FOR INDUCING IMMUNE TOLERANCE

IN VITRO PRODUCTION OF HIGH AFFINITY MONOCLONAL ANTIBODIES

PRODUCTION OF A BIOENGINEERED LUNG

METHOD FOR ACTIVATING T CELLS FOR CANCER TREATMENT

B-CELL CULTIVATION METHOD

Expansion Of Peripheral Blood Lymphocytes (PBLS) From Peripheral Blood

METHOD FOR EXPANSION OF LYMPHOCYTES

EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND...

METHODS FOR GENERATING POLYCLONAL REGULATORY T CELLS

TREATMENT OF LIVER FAILURE WITH ACTIVATED T REGULATORY CELLS

B-cell cultivation method

REGULATORY B CELLS AND USES THEREOF

CULTURE MEDIA FOR SIMULTANEOUS TESTING OF MULTIPLE HEMATOPOIETIC DI...

IN VITRO NEONATAL BIOMIMETIC (NMIMIC) MODEL AND METHODS OF USING SAME

TRANSFECTION OF DENDRITIC CELLS AND METHODS THEREFOR