Bones Osteocytes Osteoblasts Tendons Tenocytes Teeth Odontoblasts Cartilage Chondrocytes Synovial membrane

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AHUMAN NECESSITIES A61Medical science A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution

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A61K35/32Bones Osteocytes Osteoblasts Tendons Tenocytes Teeth Odontoblasts Cartilage Chondrocytes Synovial membrane

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Patents Grantslast 30 patents

Information Patent Grant
Pharmaceutical composition for promoting osteogenesis, comprising o...
- Patent number 12,318,409
- Issue date Jun 3, 2025
- Seoul National University R&DB Foundation
- Yun-Sil Lee
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Injectable pastes based on oppositely charged polymer/calcium phosp...
- Patent number 12,318,475
- Issue date Jun 3, 2025
- The University of Chicago
- Juan Jose de Pablo
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Tissue processing apparatus and method for processing adipose tissue
- Patent number 12,305,159
- Issue date May 20, 2025
- William W. Cimino
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Non-cultured, partially digested, cryopreserved cartilage product
- Patent number 12,268,797
- Issue date Apr 8, 2025
- Osiris Therapeutics, Inc.
- Dana Sue Yoo
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Pharmaceutical composition comprising periodontal tissue-derived pl...
- Patent number 12,239,668
- Issue date Mar 4, 2025
- Industry-Academic Cooperation Foundation Gyeongsang National University
- Gyu Jin Rho
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Use of stem cells expressing mesenchymal and neuronal markers and c...
- Patent number 12,239,670
- Issue date Mar 4, 2025
- Avita International Ltd.
- Irina Kerkis
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Musculoskeletal stem cell and medium for inducing differentiation o...
- Patent number RE50313
- Issue date Feb 25, 2025
- CELLATOZ THERAPEUTICS, INC.
- Myung-Kwan Han
Information Patent Grant
Compositions and methods for supporting nucleus pulposus (NP) cell...
- Patent number 12,213,997
- Issue date Feb 4, 2025
- Washington University
- Lori Setton
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Traditional Chinese medicine mixture and traditional Chinese medici...
- Patent number 12,194,063
- Issue date Jan 14, 2025
- BEIJING UNIVERSITY OF CHINESE MEDICINE
- Anlong Xu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods useful in regenerative medicine
- Patent number 12,186,452
- Issue date Jan 7, 2025
- Yale University
- Themis Kyriakides
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Isoform Nell-1 peptide
- Patent number 12,186,367
- Issue date Jan 7, 2025
- The Regents of the University of California
- Kang Ting
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Bone marrow harvesting and storage
- Patent number 12,171,441
- Issue date Dec 24, 2024
- Stryker European Operations Holdings LLC
- Nils Reimers
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Bone grafts including osteogenic stem cells, and methods relating t...
- Patent number 12,161,780
- Issue date Dec 10, 2024
- Globus Medical, Inc.
- Archana Bhat
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for preparing pellets of chondrocytes from human induced plu...
- Patent number 12,163,157
- Issue date Dec 10, 2024
- YiPCELL Inc.
- Ji Hyeon Ju
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Oral composition comprising lactic acid bacteria for regulating imm...
- Patent number 12,156,893
- Issue date Dec 3, 2024
- The Regents of the University of California
- Anahid Jewett
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for preparing active protein peptide and prepared active pro...
- Patent number 12,152,266
- Issue date Nov 26, 2024
- Shuang Liu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Composition for promoting stem cell differentiation, comprising pro...
- Patent number 12,139,725
- Issue date Nov 12, 2024
- Seoul National University R&DB Foundation
- Jeong Mook Lim
- C01 - INORGANIC CHEMISTRY
Information Patent Grant
Electrical stimulation of cells to induce enhanced secretome for th...
- Patent number 12,133,881
- Issue date Nov 5, 2024
- University of Florida Research Foundation, Inc.
- Christine E. Schmidt
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Platelet lysate, and method of preparation thereof
- Patent number 12,097,221
- Issue date Sep 24, 2024
- REGROW BIOSCIENCES PRIVATE LIMITED
- Satyen Sanghavi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for preparing a bone protein preparation and a bone protein...
- Patent number 12,097,243
- Issue date Sep 24, 2024
- BBS-BIOACTIVE BONE SUBSTITUTES OYJ
- Hanna Tölli
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Demineralized bone fibers and preparation thereof
- Patent number 12,090,250
- Issue date Sep 17, 2024
- Lifenet Health
- Silvia Chen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods to improve cell therapy
- Patent number 12,090,173
- Issue date Sep 17, 2024
- The Brigham & Women's Hospital, Inc.
- Robert Sackstein
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Extracts for the regeneration of ligaments
- Patent number 12,070,475
- Issue date Aug 27, 2024
- University of Pittsburgh of the Commonwealth System of Higher Education
- Riccardo Luca Gottardi
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Osteoinductive putties and methods of making and using such putties
- Patent number 12,059,439
- Issue date Aug 13, 2024
- RTI Surgical, Inc.
- Jordan Katz
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for promoting the mineralization of biolog...
- Patent number 11,992,517
- Issue date May 28, 2024
- New York Society for the Relief of the Ruptured and Crippled, Maintaining the...
- Matthew E. Cunningham
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Composition for preventing, alleviating or treating burnout syndrome
- Patent number 11,975,037
- Issue date May 7, 2024
- Amorepacific Corporation
- Su-Hwan Kim
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Grant
Methods for generating multipotent stem cells from tonsillar biopsies
- Patent number 11,957,718
- Issue date Apr 16, 2024
- University of Maryland, Baltimore
- Michal Zalzman
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Engineered tendon graft for rotator cuff repair
- Patent number 11,944,532
- Issue date Apr 2, 2024
- The Regents of the University of Michigan
- Lisa M. Larkin
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Fluoro beta-carboline compounds
- Patent number 11,903,949
- Issue date Feb 20, 2024
- OSSIFI THERAPEUTICS LLC
- Debra Ellies
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Tissue processing apparatus and method for processing adipose tissue
- Patent number 11,898,138
- Issue date Feb 13, 2024
- THE GID GROUP, INC.
- William W. Cimino
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
COMPOSITION FOR TREATMENT OF CARTILAGE-RELATED DISEASE AND PREPARAT...
- Publication number 20250134933
- Publication date May 1, 2025
- YOUTH BIO GLOBAL CO., LTD.
- SEUNG HO YOO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Bone Grafts Including Osteogenic Stem Cells and Methods Relating to...
- Publication number 20250099652
- Publication date Mar 27, 2025
- Globus Medical, Inc
- Archana Bhat
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
- Publication number 20250090635
- Publication date Mar 20, 2025
- Kolon TissueGene, Inc.
- Moon Jong Noh
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHOD FOR PRODUCING HYDROGEL MICROBEADS CAPABLE OF MAGNETIC ACTUAT...
- Publication number 20250090593
- Publication date Mar 20, 2025
- Biot Korea Inc.
- Yeong Jun CHANG
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
HPSC-DERIVED ARTICULAR CHONDROCYTE COMPOSITIONS, SYSTEMS AND METHOD...
- Publication number 20250064859
- Publication date Feb 27, 2025
- The Children's Medical Center Corporation
- April M. Craft
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Bone Marrow Harvesting and Storage
- Publication number 20250064461
- Publication date Feb 27, 2025
- Stryker European Operations Holdings LLC
- Nils Reimers
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITION FOR OBTAINING A MATERIAL FOR TISSUE REGENERATION OR REC...
- Publication number 20250049858
- Publication date Feb 13, 2025
- BRENTA S.r.l.
- Andrea CASTELLIN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR ACTIVATING NK CELLS
- Publication number 20250049859
- Publication date Feb 13, 2025
- The Regents of the University of California
- Anahid Jewett
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
FLUORO BETA-CARBOLINE COMPOUNDS
- Publication number 20250025472
- Publication date Jan 23, 2025
- OSSIFI THERAPEUTICS LLC
- Debra Ellies
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TRADITIONAL CHINESE MEDICINE COMPOSITION AND USE THEREOF
- Publication number 20250017978
- Publication date Jan 16, 2025
- Jiangsu Kanion Pharmaceutical Co., Ltd.
- Wei XIAO
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
- Publication number 20250018011
- Publication date Jan 16, 2025
- Kolon TissueGene, Inc.
- Moon Jong Noh
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CERAMIDASE AND CELL DIFFERENTIATION
- Publication number 20250018017
- Publication date Jan 16, 2025
- Icahn School of Medicine at Mount Sinai
- Edward H. Schuchman
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
AGENT FOR IMPROVING CANCER CACHEXIA AND METHOD FOR IMPROVING CANCER...
- Publication number 20240424029
- Publication date Dec 26, 2024
- DEXON PHARMACEUTICALS INC.
- Shoji KOGA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Extracts for the Regeneration of Ligaments
- Publication number 20240374650
- Publication date Nov 14, 2024
- University of Pittsburgh of the Commonwealth System of Higher Education
- Riccardo Luca Gottardi
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
STEM CELL INDUCTION INTO PRECHONDROCYTES AND DIFFERENTIATION INTO C...
- Publication number 20240376433
- Publication date Nov 14, 2024
- SMART CELL LAB CO., LTD.
- Jung Hwa Kang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR CELL-BASED DELIVERY SYSTEMS
- Publication number 20240342220
- Publication date Oct 17, 2024
- Washington University
- Farshid Guilak
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TREATMENT OF BONE TISSUE TO INCREASE THE BIOAVAILABILITY OF GROWTH...
- Publication number 20240335509
- Publication date Oct 10, 2024
- RED ROCK REGENERATION INC.
- Sean A.F. Peel
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MEDICINE COMPOSITION FOR TREATMENT OF BONE AND JOINT DISEASES ORIGI...
- Publication number 20240307458
- Publication date Sep 19, 2024
- SAO THAI DUONG JOINT STOCK COMPANY
- Thi Huong Lien NGUYEN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHOD FOR PREPARING INJECTABLE INJECTION COMPOSITION DERIVED FROM...
- Publication number 20240299460
- Publication date Sep 12, 2024
- KANGSTEM BIOTECH CO., LTD.
- Kyung Sun Kang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TISSUE PROCESSING APPARATUS AND METHOD FOR PROCESSING ADIPOSE TISSUE
- Publication number 20240279589
- Publication date Aug 22, 2024
- GID BIO, Inc.
- William W. Cimino
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
OCULAR SYMPTOM-IMPROVING AGENT AND METHOD FOR IMPROVING OCULAR SYMPTOM
- Publication number 20240269191
- Publication date Aug 15, 2024
- PANAGY CO., LTD.
- Shoji KOGA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CELLULAR COMPOSITIONS FOR TREATING BACK PAIN
- Publication number 20240269190
- Publication date Aug 15, 2024
- The United States Government as Represented by the Department of Veterans Aff...
- LACHLAN JAMES SMITH
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MULTI-TISSUE ORGANOID PRODUCTS AND METHODS
- Publication number 20240271105
- Publication date Aug 15, 2024
- Regents of the University of Minnesota
- Timothy D. O'Brien
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR PROMOTING THE MINERALIZATION OF BIOLOG...
- Publication number 20240252600
- Publication date Aug 1, 2024
- NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HO
- Matthew E. Cunningham
- C07 - ORGANIC CHEMISTRY
Information Patent Application
COMPOSITIONS COMPRISING STEM CELLS EXPRESSING MESENCHYMAL AND NEURO...
- Publication number 20240245727
- Publication date Jul 25, 2024
- Avita International Ltd.
- Irina Kerkis
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BONE DISEASE TREATMENT
- Publication number 20240226227
- Publication date Jul 11, 2024
- The University of Birmingham
- George Edward Rainger
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
AGENT FOR IMPROVING CANCER CACHEXIA AND METHOD FOR IMPROVING CANCER...
- Publication number 20240216441
- Publication date Jul 4, 2024
- DEXON PHARMACEUTICALS INC.
- Shoji KOGA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHOD FOR DIFFERENTIATION TO STEM CELL DERIVED HYALINE CARTILAGE S...
- Publication number 20240200032
- Publication date Jun 20, 2024
- CELLOID CO., LTD.
- Dong Sung KIM
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TRADITIONAL CHINESE MEDICINE MIXTURE AND TRADITIONAL CHINESE MEDICI...
- Publication number 20240180973
- Publication date Jun 6, 2024
- BEIJING UNIVERSITY OF CHINESE MEDICINE
- Anlong XU
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ISOLATED DISCOGENIC CELLS, METHODS OF USING, AND METHODS OF PREPARI...
- Publication number 20240182861
- Publication date Jun 6, 2024
- DiscGenics, Inc.
- Lara Ionescu Silverman
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Bones Osteocytes Osteoblasts Tendons Tenocytes Teeth Odontoblasts Cartilage Chondrocytes Synovial membrane

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Pharmaceutical composition for promoting osteogenesis, comprising o...

Injectable pastes based on oppositely charged polymer/calcium phosp...

Tissue processing apparatus and method for processing adipose tissue

Non-cultured, partially digested, cryopreserved cartilage product

Pharmaceutical composition comprising periodontal tissue-derived pl...

Use of stem cells expressing mesenchymal and neuronal markers and c...

Musculoskeletal stem cell and medium for inducing differentiation o...

Compositions and methods for supporting nucleus pulposus (NP) cell...

Traditional Chinese medicine mixture and traditional Chinese medici...

Compositions and methods useful in regenerative medicine

Isoform Nell-1 peptide

Bone marrow harvesting and storage

Bone grafts including osteogenic stem cells, and methods relating t...

Method for preparing pellets of chondrocytes from human induced plu...

Oral composition comprising lactic acid bacteria for regulating imm...

Method for preparing active protein peptide and prepared active pro...

Composition for promoting stem cell differentiation, comprising pro...

Electrical stimulation of cells to induce enhanced secretome for th...

Platelet lysate, and method of preparation thereof

Method for preparing a bone protein preparation and a bone protein...

Demineralized bone fibers and preparation thereof

Methods to improve cell therapy

Extracts for the regeneration of ligaments

Osteoinductive putties and methods of making and using such putties

Compositions and methods for promoting the mineralization of biolog...

Composition for preventing, alleviating or treating burnout syndrome

Methods for generating multipotent stem cells from tonsillar biopsies

Engineered tendon graft for rotator cuff repair

Fluoro beta-carboline compounds

Tissue processing apparatus and method for processing adipose tissue

Patents Applicationslast 30 patents

COMPOSITION FOR TREATMENT OF CARTILAGE-RELATED DISEASE AND PREPARAT...

Bone Grafts Including Osteogenic Stem Cells and Methods Relating to...

TREATMENT OF INTERVERTEBRAL DISC DEGENERATION

METHOD FOR PRODUCING HYDROGEL MICROBEADS CAPABLE OF MAGNETIC ACTUAT...

HPSC-DERIVED ARTICULAR CHONDROCYTE COMPOSITIONS, SYSTEMS AND METHOD...

Bone Marrow Harvesting and Storage

COMPOSITION FOR OBTAINING A MATERIAL FOR TISSUE REGENERATION OR REC...

COMPOSITIONS AND METHODS FOR ACTIVATING NK CELLS

FLUORO BETA-CARBOLINE COMPOUNDS

TRADITIONAL CHINESE MEDICINE COMPOSITION AND USE THEREOF

TREATMENT OF INTERVERTEBRAL DISC DEGENERATION

CERAMIDASE AND CELL DIFFERENTIATION

AGENT FOR IMPROVING CANCER CACHEXIA AND METHOD FOR IMPROVING CANCER...

Extracts for the Regeneration of Ligaments

STEM CELL INDUCTION INTO PRECHONDROCYTES AND DIFFERENTIATION INTO C...

COMPOSITIONS AND METHODS FOR CELL-BASED DELIVERY SYSTEMS

TREATMENT OF BONE TISSUE TO INCREASE THE BIOAVAILABILITY OF GROWTH...

MEDICINE COMPOSITION FOR TREATMENT OF BONE AND JOINT DISEASES ORIGI...

METHOD FOR PREPARING INJECTABLE INJECTION COMPOSITION DERIVED FROM...

TISSUE PROCESSING APPARATUS AND METHOD FOR PROCESSING ADIPOSE TISSUE

OCULAR SYMPTOM-IMPROVING AGENT AND METHOD FOR IMPROVING OCULAR SYMPTOM

CELLULAR COMPOSITIONS FOR TREATING BACK PAIN

MULTI-TISSUE ORGANOID PRODUCTS AND METHODS

COMPOSITIONS AND METHODS FOR PROMOTING THE MINERALIZATION OF BIOLOG...

COMPOSITIONS COMPRISING STEM CELLS EXPRESSING MESENCHYMAL AND NEURO...

BONE DISEASE TREATMENT

AGENT FOR IMPROVING CANCER CACHEXIA AND METHOD FOR IMPROVING CANCER...

METHOD FOR DIFFERENTIATION TO STEM CELL DERIVED HYALINE CARTILAGE S...

TRADITIONAL CHINESE MEDICINE MIXTURE AND TRADITIONAL CHINESE MEDICI...

ISOLATED DISCOGENIC CELLS, METHODS OF USING, AND METHODS OF PREPARI...