fusions for targeting to specific cell types

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CCHEMISTRY METALLURGY C07Organic chemistry C07KPEPTIDES C07K2319/00Fusion polypeptide

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C07K2319/33fusions for targeting to specific cell types

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Patents Grantslast 30 patents

Information Patent Grant
Synthetic immune receptors and methods of use thereof
- Patent number 12,269,859
- Issue date Apr 8, 2025
- Angeles Therapeutics, Inc.
- Preet M. Chaudhary
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Chimeric antigen receptor effector cell switches with humanized tar...
- Patent number 12,269,869
- Issue date Apr 8, 2025
- The Scripps Research Institute
- Travis S. Young
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Antigen binding regions against fibronectin type III domains and me...
- Patent number 12,269,870
- Issue date Apr 8, 2025
- Janssen Biotech, Inc.
- Chichi Huang
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Codon-optimized nucleotide sequences encoding an AP-1 transcription...
- Patent number 12,270,032
- Issue date Apr 8, 2025
- LYELL IMMUNOPHARMA, INC.
- Spencer Park
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Chimeric antigen receptor comprising BCMA nanobody linked to a chim...
- Patent number 12,263,221
- Issue date Apr 1, 2025
- Neomics Pharmaceuticals LLC
- William A. Comrie
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Repair of UV-induced DNA lesions
- Patent number 12,264,347
- Issue date Apr 1, 2025
- Jeroen Hofenk
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods for immunotherapy
- Patent number 12,263,220
- Issue date Apr 1, 2025
- Memorial Sloan Kettering Cancer Center
- Christopher C. Kloss
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Panel comprising Borrelia MHC multimers
- Patent number 12,258,373
- Issue date Mar 25, 2025
- Immudex ApS
- Liselotte Brix
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Claudin18.2 binding moieties and uses thereof
- Patent number 12,258,418
- Issue date Mar 25, 2025
- Nanjing GenScript Biotech Co., Ltd.
- Liusong Yin
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Adenovirus vectors and methods for using adenovirus vectors
- Patent number 12,258,572
- Issue date Mar 25, 2025
- Mayo Foundation for Medical Education and Research
- Michael A. Barry
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Methods and compositions for transducing lymphocytes and regulating...
- Patent number 12,258,574
- Issue date Mar 25, 2025
- Exuma Biotech Corp.
- Gregory Ian Frost
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Methods and compositions for therapeutic protein delivery
- Patent number 12,258,597
- Issue date Mar 25, 2025
- REGENERON PHARMACEUTICALS, INC.
- Andrew Baik
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Activating chimeric receptors and uses thereof in natural killer ce...
- Patent number 12,258,381
- Issue date Mar 25, 2025
- National University of Singapore
- See Voon Seow
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Production of engineered T-cells by sleeping beauty transposon coup...
- Patent number 12,258,397
- Issue date Mar 25, 2025
- Seattle Children's Hospital
- Michael C. Jensen
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
IL-21 polypeptides and targeted constructs
- Patent number 12,247,072
- Issue date Mar 11, 2025
- Asher Biotherapeutics, Inc.
- Yik Andy Yeung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods for improving the efficacy and expansion of immune cells
- Patent number 12,240,884
- Issue date Mar 4, 2025
- Novartis AG
- Felipe Bedoya
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
CAR library and scFv manufacturing method
- Patent number 12,241,061
- Issue date Mar 4, 2025
- National University Corporation Ehime University
- Toshiki Ochi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
De novo design of potent and selective interleukin mimetics
- Patent number 12,240,880
- Issue date Mar 4, 2025
- University of Washington
- Daniel Adriano Silva Manzano
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Hepatitis B vaccines and uses of the same
- Patent number 12,234,261
- Issue date Feb 25, 2025
- PRECIGEN, INC.
- Douglas E. Brough
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
De novo design of potent and selective interleukin mimetics
- Patent number 12,227,553
- Issue date Feb 18, 2025
- University of Washington
- Daniel Adriano Silva Manzano
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-BCMA single domain antibodies and application thereof
- Patent number 12,227,581
- Issue date Feb 18, 2025
- SHENZHEN PREGENE BIOPHARMA CO., LTD.
- Jishuai Zhang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Epcam antibody and Epcam-CAR-T cells
- Patent number 12,227,589
- Issue date Feb 18, 2025
- Forevertek Biotechnology Co., Ltd.
- Lijun Wu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Membrane bound IL12 compositions and methods for tunable regulation
- Patent number 12,227,551
- Issue date Feb 18, 2025
- Obsidian Therapeutics, Inc.
- Michelle Lynn Ols
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Use of CD2/5/7 knock-out anti-CD2/5/7 chimeric antigen receptor T c...
- Patent number 12,227,588
- Issue date Feb 18, 2025
- The Trustees of the University of Pennsylvania
- Marco Ruella
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and composition for a binding molecule targeting cancer cel...
- Patent number 12,227,590
- Issue date Feb 18, 2025
- CHILDREN'S NATIONAL MEDICAL CENTER
- Eric Yvon
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods and compositions for treating cancer
- Patent number 12,227,763
- Issue date Feb 18, 2025
- CRISPR THERAPEUTICS AG
- Jonathan Alexander Terrett
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Targeted gene integration of CRS inhibitor genes for improved immun...
- Patent number 12,221,478
- Issue date Feb 11, 2025
- Cellectis
- Brian Busser
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Chimeric antigen receptor and application thereof
- Patent number 12,221,475
- Issue date Feb 11, 2025
- CAS Lamvac (Guangzhou) Biomedical Technology Co., Ltd.
- Wen Hu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and compositions for dosing of allogeneic chimeric antigen...
- Patent number 12,221,462
- Issue date Feb 11, 2025
- Allogene Therapeutics, Inc.
- Cyril Alkis Konto
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Complex comprising a cell penetrating peptide, a cargo and a TLR pe...
- Patent number 12,220,450
- Issue date Feb 11, 2025
- AMAL THERAPEUTICS SA
- Madiha Derouazi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
AFFINITY-ENHANCED MONMERIC STREPTAVIDIN CHIMERIC ANTIGEN RECEPTOR (...
- Publication number 20250115644
- Publication date Apr 10, 2025
- University of Pittsburgh of the Commonwealth System of Higher Education
- Jason Lohmueller
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MULTI-SPECIFIC BINDING MOLECULES TARGETING ABERRANT CELLS
- Publication number 20250115662
- Publication date Apr 10, 2025
- APO-T B.V.
- Ralph Alexander Willemsen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Gamma Delta T-Cell-Targeted Modified IL-2 Polypeptides and Uses The...
- Publication number 20250109203
- Publication date Apr 3, 2025
- Inhibrx Biosciences, Inc.
- Bryan R. Becklund
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY
- Publication number 20250109401
- Publication date Apr 3, 2025
- Novartis AG
- Jennifer BROGDON
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMMUNOSUPPRESSIVE ANTIGEN-SPECIFIC CHIMERIC ANTIGEN RECEPTOR TREG C...
- Publication number 20250099562
- Publication date Mar 27, 2025
- The University of Toledo
- Juan C. Jaume
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
- Publication number 20250101080
- Publication date Mar 27, 2025
- Biosceptre (Aust) Pty Ltd
- Justin Taylor Coombs
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER
- Publication number 20250101135
- Publication date Mar 27, 2025
- HOFFMANN-LA ROCHE INC.
- Maria Amann
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CHIMERIC ANTIGEN RECEPTOR T CELLS (CAR-T) FOR THE TREATMENT OF CANCER
- Publication number 20250101099
- Publication date Mar 27, 2025
- Washington University
- John DiPersio
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NOVEL CRISPR ENZYMES AND SYSTEMS
- Publication number 20250101400
- Publication date Mar 27, 2025
- THE BROAD INSTITUTE, INC.
- Feng Zhang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
BAFF-R TARGETED CHIMERIC ANTIGEN RECEPTOR-MODIFIED T-CELLS AND USES...
- Publication number 20250092149
- Publication date Mar 20, 2025
- CITY OF HOPE
- Hong QIN
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CHIMERIC ANTIGEN RECEPTOR SPECIFIC FOR INTERLEUKIN-23 RECEPTOR
- Publication number 20250092145
- Publication date Mar 20, 2025
- SANGAMO THERAPEUTICS FRANCE
- Tobias Abel
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Method of Redirecting T Cells to Treat HIV Infection
- Publication number 20250084147
- Publication date Mar 13, 2025
- The Trustees of the University of Pennsylvania
- James L. Riley
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR DOSING OF ALLOGENEIC CHIMERIC ANTIGEN...
- Publication number 20250084149
- Publication date Mar 13, 2025
- Allogene Therapeutics, Inc.
- Cyril Alkis KONTO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Compositions and Methods for Treating Cancer with Anti-CD19/CD22 Im...
- Publication number 20250084166
- Publication date Mar 13, 2025
- Lentigen Technology, Inc.
- Dina Schneider
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR DELIVERING CARGO TO A TARGET CELL
- Publication number 20250073350
- Publication date Mar 6, 2025
- THE BROAD INSTITUTE, INC.
- Feng Zhang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Transgenic Macrophages, Chimeric Antigen Receptors, and Associated...
- Publication number 20250075181
- Publication date Mar 6, 2025
- Thunder Biotech, Inc.
- Kim Leslie O'Neill
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CATENATED VAR2CSA RECOMBINANT PROTEIN, PREPARATION METHOD THEREFOR,...
- Publication number 20250073269
- Publication date Mar 6, 2025
- CAS LAMVAC (GUANGZHOU) BIOMEDICAL TECHNOLOGY CO., LTD
- Wen Hu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
FUSION MOLECULES AND IL-15 VARIANTS
- Publication number 20250066442
- Publication date Feb 27, 2025
- Altor BioScience LLC
- Hing C. Wong
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
A CONJUGATE FOR USE IN LOCALISING A MOLECULE TO THE VASCULAR ENDOTH...
- Publication number 20250066436
- Publication date Feb 27, 2025
- Royal College of Surgeons in Ireland
- Roger PRESTON
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ERYTHROCYTE-BINDING THERAPEUTICS
- Publication number 20250059263
- Publication date Feb 20, 2025
- ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
- Jeffrey A. Hubbell
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CHIMERIC ANTIGEN RECEPTORS TARGETING FC RECEPTOR-LIKE 5 AND USES TH...
- Publication number 20250059283
- Publication date Feb 20, 2025
- Memorial Sloan-Kettering Cancer Center
- Renier J. Brentjens
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Immunosuppressive Antigen-Specific Chimeric Antigen Receptor Treg C...
- Publication number 20250059252
- Publication date Feb 20, 2025
- The University of Toledo
- Juan C. Jaume
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CELL TARGETING COMPOSITIONS AND METHODS
- Publication number 20250051406
- Publication date Feb 13, 2025
- THE TRUSTEES OF INDIANA UNIVERSITY
- Milan Radovich
- G01 - MEASURING TESTING
Information Patent Application
CONSTITUTIVELY ACTIVE CHIMERIC CYTOKINE RECEPTORS
- Publication number 20250051421
- Publication date Feb 13, 2025
- Allogene Therapeutics, Inc.
- Regina Junhui LIN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTI-B7-H3 MONOCLONAL ANTIBODY AND USE THEREOF IN CELL THERAPY
- Publication number 20250051451
- Publication date Feb 13, 2025
- FUZHOU TCELLTECH BIOTECHNOLOGY CO., LTD.
- Gangxiong HUANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
T Cell Modification and Use Thereof
- Publication number 20250043011
- Publication date Feb 6, 2025
- ADAPTIMMUNE LIMITED
- Garth Hamilton
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NUCLEIC ACID CONSTRUCTS FOR CO-EXPRESSION OF CHIMERIC ANTIGEN RECEP...
- Publication number 20250034217
- Publication date Jan 30, 2025
- The Trustees of Dartmouth College
- Charles L. Sentman
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IL-21 POLYPEPTIDES AND TARGETED CONSTRUCTS
- Publication number 20250034242
- Publication date Jan 30, 2025
- Asher Biotherapeutics, Inc.
- Yik Andy Yeung
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
IMMUNE CELL COMPOSITIONS AND METHODS OF USE
- Publication number 20250034228
- Publication date Jan 30, 2025
- Memorial Sloan-Kettering Cancer Center
- Prasad S. Adusumilli
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND COMPOSITIONS FOR TREATING HYPOPHOSPHATASIA
- Publication number 20250034534
- Publication date Jan 30, 2025
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Koichi MIYAKE
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

fusions for targeting to specific cell types

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Synthetic immune receptors and methods of use thereof

Chimeric antigen receptor effector cell switches with humanized tar...

Antigen binding regions against fibronectin type III domains and me...

Codon-optimized nucleotide sequences encoding an AP-1 transcription...

Chimeric antigen receptor comprising BCMA nanobody linked to a chim...

Repair of UV-induced DNA lesions

Compositions and methods for immunotherapy

Panel comprising Borrelia MHC multimers

Claudin18.2 binding moieties and uses thereof

Adenovirus vectors and methods for using adenovirus vectors

Methods and compositions for transducing lymphocytes and regulating...

Methods and compositions for therapeutic protein delivery

Activating chimeric receptors and uses thereof in natural killer ce...

Production of engineered T-cells by sleeping beauty transposon coup...

IL-21 polypeptides and targeted constructs

Methods for improving the efficacy and expansion of immune cells

CAR library and scFv manufacturing method

De novo design of potent and selective interleukin mimetics

Hepatitis B vaccines and uses of the same

De novo design of potent and selective interleukin mimetics

Anti-BCMA single domain antibodies and application thereof

Epcam antibody and Epcam-CAR-T cells

Membrane bound IL12 compositions and methods for tunable regulation

Use of CD2/5/7 knock-out anti-CD2/5/7 chimeric antigen receptor T c...

Methods and composition for a binding molecule targeting cancer cel...

Methods and compositions for treating cancer

Targeted gene integration of CRS inhibitor genes for improved immun...

Chimeric antigen receptor and application thereof

Methods and compositions for dosing of allogeneic chimeric antigen...

Complex comprising a cell penetrating peptide, a cargo and a TLR pe...

Patents Applicationslast 30 patents

AFFINITY-ENHANCED MONMERIC STREPTAVIDIN CHIMERIC ANTIGEN RECEPTOR (...

MULTI-SPECIFIC BINDING MOLECULES TARGETING ABERRANT CELLS

Gamma Delta T-Cell-Targeted Modified IL-2 Polypeptides and Uses The...

COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY

IMMUNOSUPPRESSIVE ANTIGEN-SPECIFIC CHIMERIC ANTIGEN RECEPTOR TREG C...

CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER

CHIMERIC ANTIGEN RECEPTOR T CELLS (CAR-T) FOR THE TREATMENT OF CANCER

NOVEL CRISPR ENZYMES AND SYSTEMS

BAFF-R TARGETED CHIMERIC ANTIGEN RECEPTOR-MODIFIED T-CELLS AND USES...

CHIMERIC ANTIGEN RECEPTOR SPECIFIC FOR INTERLEUKIN-23 RECEPTOR

Method of Redirecting T Cells to Treat HIV Infection

METHODS AND COMPOSITIONS FOR DOSING OF ALLOGENEIC CHIMERIC ANTIGEN...

Compositions and Methods for Treating Cancer with Anti-CD19/CD22 Im...

COMPOSITIONS AND METHODS FOR DELIVERING CARGO TO A TARGET CELL

Transgenic Macrophages, Chimeric Antigen Receptors, and Associated...

CATENATED VAR2CSA RECOMBINANT PROTEIN, PREPARATION METHOD THEREFOR,...

FUSION MOLECULES AND IL-15 VARIANTS

A CONJUGATE FOR USE IN LOCALISING A MOLECULE TO THE VASCULAR ENDOTH...

ERYTHROCYTE-BINDING THERAPEUTICS

CHIMERIC ANTIGEN RECEPTORS TARGETING FC RECEPTOR-LIKE 5 AND USES TH...

Immunosuppressive Antigen-Specific Chimeric Antigen Receptor Treg C...

CELL TARGETING COMPOSITIONS AND METHODS

CONSTITUTIVELY ACTIVE CHIMERIC CYTOKINE RECEPTORS

ANTI-B7-H3 MONOCLONAL ANTIBODY AND USE THEREOF IN CELL THERAPY

T Cell Modification and Use Thereof

NUCLEIC ACID CONSTRUCTS FOR CO-EXPRESSION OF CHIMERIC ANTIGEN RECEP...

IL-21 POLYPEPTIDES AND TARGETED CONSTRUCTS

IMMUNE CELL COMPOSITIONS AND METHODS OF USE

METHODS AND COMPOSITIONS FOR TREATING HYPOPHOSPHATASIA