involving phosphatase

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CPC
C12Q1/42

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CCHEMISTRY METALLURGY C12Biochemistry C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS COMPOSITIONS OR TEST PAPERS THEREFOR PROCESSES OF PREPARING SUCH COMPOSITIONS CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or micro-organisms Compositions therefor Processes of preparing such compositions

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C12Q1/42involving phosphatase

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Patents Grantslast 30 patents

Information Patent Grant
Mass spectrometry method for measuring thiamine in body fluid
- Patent number 12,116,617
- Issue date Oct 15, 2024
- Quest Diagnostics Investments Incorporated
- Sum Chan
- G01 - MEASURING TESTING
Information Patent Grant
Systems and methods for multi-analysis
- Patent number 12,085,583
- Issue date Sep 10, 2024
- Labrador Diagnostics LLC
- Elizabeth A. Holmes
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Methods and compositions for synthetic biomarkers
- Patent number 12,060,613
- Issue date Aug 13, 2024
- EARLI Inc.
- David Suhy
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method of preparation of nanopore and uses thereof
- Patent number 11,795,191
- Issue date Oct 24, 2023
- The Trustees of Columbia University In the City of New York
- Jingyue Ju
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Quinone methide analog signal amplification
- Patent number 11,780,863
- Issue date Oct 10, 2023
- Ventana Medical Systems, Inc.
- Christopher Bieniarz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for detection of rare subpopulations of cells and highly pu...
- Patent number 11,739,366
- Issue date Aug 29, 2023
- Astellas Institute for Regenerative Medicine
- Irina V. Klimanskaya
- G01 - MEASURING TESTING
Information Patent Grant
Systems and methods for sample use maximization
- Patent number 11,644,410
- Issue date May 9, 2023
- Labrador Diagnostics LLC
- Anthony J. Nugent
- B04 - CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL...
Information Patent Grant
Enzyme-specific intracellularly-retained red fluorescent probe
- Patent number 11,591,359
- Issue date Feb 28, 2023
- The University of Tokyo
- Yasuteru Urano
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Immobilized protein system for rapid and enhanced multiplexed diagn...
- Patent number 11,549,953
- Issue date Jan 10, 2023
- Cornell University
- Alexander J. A. Travis
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Medium for detecting Staphylococcus aureus, sheet for detecting S....
- Patent number 11,505,816
- Issue date Nov 22, 2022
- Kikkoman Corporation
- Keisuke Kazama
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions and methods to detect gastrointestinal disease
- Patent number 11,493,515
- Issue date Nov 8, 2022
- The Board of Supervisors of Louisiana State University and Agricultural and M...
- Sunyoung Kim
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Thermostable haloarchaeal inorganic pyrophosphatase
- Patent number 11,466,260
- Issue date Oct 11, 2022
- University of Florida Research Foundation, Inc.
- Julie A. Maupin-Furlow
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and reagents useful for verification of the integrity of a...
- Patent number 11,460,409
- Issue date Oct 4, 2022
- VISION DIAGNOSTICS, INC.
- Jerry W. Denney
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Pharmaceutical compositions for use in the treatment of cardiovascu...
- Patent number 11,382,894
- Issue date Jul 12, 2022
- INSERM (Institut National de la Sante et de la Recherche Medicale)
- Jeremy Bellien
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for selecting phosphatase selective and non-selective phosp...
- Patent number 11,364,211
- Issue date Jun 21, 2022
- United Kingdom Research and Innovation
- Anne Bertolotti
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Quinone methide analog signal amplification
- Patent number 11,365,210
- Issue date Jun 21, 2022
- Ventana Medical Systems, Inc.
- Christopher Bieniarz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Inhibitors and their uses
- Patent number 11,337,941
- Issue date May 24, 2022
- United Kingdom Research and Innovation
- Anne Bertolotti
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitors and their uses
- Patent number 11,331,286
- Issue date May 17, 2022
- United Kingdom Research and Innovation
- Anne Bertolotti
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Biomarkers of therapeutic responsiveness
- Patent number 11,327,076
- Issue date May 10, 2022
- Meso Scale Technologies, LLC.
- Simone Barbero
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Ultra-high-sensitive assay of protein and nucleic acid and kit, and...
- Patent number 11,221,299
- Issue date Jan 11, 2022
- Etsuro Ito
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Systems and methods for sample use maximization
- Patent number 11,199,489
- Issue date Dec 14, 2021
- Labrador Diagnostics LLC
- Ian Gibbons
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Chemical tools for imaging phospholipase D activity
- Patent number 11,198,898
- Issue date Dec 14, 2021
- Cornell University
- Jeremy Baskin
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Senescent cell biomarkers
- Patent number 11,175,290
- Issue date Nov 16, 2021
- University of Leicester
- Salvador Macip
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for detecting contaminants in solutions containing glucose...
- Patent number 11,168,348
- Issue date Nov 9, 2021
- Roquette Freres
- Pierre Lanos
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Inhibitors and their uses
- Patent number 11,154,519
- Issue date Oct 26, 2021
- United Kingdom Research and Innovation
- Anne Bertolotti
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Combination product for detecting target marker
- Patent number 11,156,602
- Issue date Oct 26, 2021
- Nichirei Biosciences Inc.
- Hirokazu Ohbayashi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for measuring tyrosine phosphatase and tyrosine kinase activity
- Patent number 11,119,095
- Issue date Sep 14, 2021
- Tokyo Institute of Technology
- Shinichi Sato
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Cellular assays with a molecular endpoint measured by SAMDI mass sp...
- Patent number 11,047,861
- Issue date Jun 29, 2021
- Northwestern University
- Milan Mrksich
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Systems and methods for multi-analysis
- Patent number 11,009,516
- Issue date May 18, 2021
- Labrador Diagnostics LLC
- Elizabeth A. Holmes
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods involving MenaINV in screening for inhibitors of cancer inv...
- Patent number 10,928,397
- Issue date Feb 23, 2021
- Massachusetts Institute of Technology
- Frank B. Gertler
- G01 - MEASURING TESTING

Patents Applicationslast 30 patents

Information Patent Application
IMMOBILIZED PROTEIN SYSTEM FOR RAPID AND ENHANCED MULTIPLEXED DIAGN...
- Publication number 20240361340
- Publication date Oct 31, 2024
- Cornell University
- Alexander J.A. Travis
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
HYBRID CLUSTERING
- Publication number 20240263229
- Publication date Aug 8, 2024
- Illumina, Inc.
- Xiaoyu Ma
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DIAGNOSTIC ASSAY FOR CLASSIC INBORN GALACTOSEMIA
- Publication number 20240247301
- Publication date Jul 25, 2024
- Ohio State Innovation Foundation
- Venkat Gopalan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
FUSION PEPTIDES OR PROTEINS, THEIR USE, AND SYSTEMS AND KITS BASED...
- Publication number 20240190928
- Publication date Jun 13, 2024
- DWI - LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN E.V.
- Ulrich SCHWANEBERG
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHODS FOR DETECTION OF RARE SUBPOPULATIONS OF CELLS AND HIGHLY PU...
- Publication number 20240026419
- Publication date Jan 25, 2024
- Astellas Institute for Regenerative Medicine
- Irina Klimanskaya
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION
- Publication number 20240018174
- Publication date Jan 18, 2024
- Ventana Medical Systems, Inc.
- Christopher Bieniarz
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ASSAY AND METHOD FOR MEASURING ALKALINE PHOSPHATASE ACTIVITY IN URI...
- Publication number 20230313264
- Publication date Oct 5, 2023
- Vision Diagnostics, Inc.
- JERRY W. DENNEY
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMMOBILIZED PROTEIN SYSTEM FOR RAPID AND ENHANCED MULTIPLEXED DIAGN...
- Publication number 20230296627
- Publication date Sep 21, 2023
- Cornell University
- Alexander J.A. Travis
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD AND DEVICE FOR ASSESSING A STATUS OF A WOUND OF A PATIENT
- Publication number 20230250466
- Publication date Aug 10, 2023
- Paul Hartmann AG
- Hans SMOLA
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
BIOLOGICALLY SYNTHESIZED HYDROXYAPATITE FOR BONE REGENERATION AND T...
- Publication number 20230220346
- Publication date Jul 13, 2023
- BioVentures, LLC
- Erming Tian
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR QUANTIFYING ETHANOLAMINE PHOSPHATE, OXIDOREDUCTASE FOR Q...
- Publication number 20230203559
- Publication date Jun 29, 2023
- KIKKOMAN CORPORATION
- Haruka HIRAGUCHI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Compounds for Treating Tauopathies and Restless Leg Syndrome and Me...
- Publication number 20230190701
- Publication date Jun 22, 2023
- The United States Government as Represented
- George Richard Uhl
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR DIAGNOSING AND TREATING BLOOD CANCER
- Publication number 20230193350
- Publication date Jun 22, 2023
- Ohara Pharmaceutical Co., Ltd.
- Yuki Kurahashi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS TO DETECT GASTROINTESTINAL DISEASE
- Publication number 20230184769
- Publication date Jun 15, 2023
- The Board of Supervisors of Louisiana State University and Agricultural and M...
- Sunyoung Kim
- A23 - FOODS OR FOODSTUFFS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Information Patent Application
VITRO DEVICE TO MEASURE STOOL ALKALINE PHOSPHATEASE
- Publication number 20230097960
- Publication date Mar 30, 2023
- MADHU S. MALO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
FLUORESCENT PROTEIN BIOSENSOR FOR DETECTION OF KINASE ACTIVITY
- Publication number 20230064490
- Publication date Mar 2, 2023
- Lucidicor Inc.
- Hung-Teh Kao
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods and Reagents Useful for Verification of the Integrity of a...
- Publication number 20220381698
- Publication date Dec 1, 2022
- Vision Diagnostics, Inc.
- Jerry W. Denney
- G01 - MEASURING TESTING
Information Patent Application
METHODS FOR SELECTING PHOSPHATASE SELECTIVE AND NON-SELECTIVE PHOSP...
- Publication number 20220313628
- Publication date Oct 6, 2022
- United Kingdom Research and Innovation
- Anne BERTOLOTTI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
BIOMARKERS OF THERAPEUTIC RESPONSIVENESS
- Publication number 20220299514
- Publication date Sep 22, 2022
- MESO SCALE TECHNOLOGIES, LLC.
- Simone Barbero
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SYSTEMS AND METHODS FOR SAMPLE USE MAXIMIZATION
- Publication number 20220252503
- Publication date Aug 11, 2022
- Labrador Diagnostics LLC
- Ian GIBBONS
- G06 - COMPUTING CALCULATING COUNTING
Information Patent Application
DATA COLLECTION METHOD TO BE USED FOR CLASSIFYING CANCER LIFE
- Publication number 20220254441
- Publication date Aug 11, 2022
- Tsuneo Kobayashi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SYSTEMS AND METHODS FOR DETECTING A PATHOGENIC ORGANISM
- Publication number 20220229057
- Publication date Jul 21, 2022
- Ramot at Tel-Aviv University Ltd.
- Fernando PATOLSKY
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Senescent Cell Biomarkers
- Publication number 20220163526
- Publication date May 26, 2022
- University of Leicester
- Salvador Macip
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS FOR TREATING DILATED CARDIOMYOPATHY
- Publication number 20220096537
- Publication date Mar 31, 2022
- Mars, Incorporated
- Anne Marie Bakke
- G01 - MEASURING TESTING
Information Patent Application
QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION
- Publication number 20220041633
- Publication date Feb 10, 2022
- Ventana Medical Systems, Inc.
- Christopher Bieniarz
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Compounds for Treating Tauopathies and Restless Leg Syndrome and Me...
- Publication number 20220031653
- Publication date Feb 3, 2022
- United States Government as Represented by the Department of Veterans Affairs
- George Richard Uhl
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHOD OF EVALUATING QUALITY OF DEPHOSPHORYLATION REAGENT AND METHO...
- Publication number 20220033874
- Publication date Feb 3, 2022
- TORAY INDUSTRIES, INC.
- Masateru Ito
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Flash and Glow 1,2-Dioxetanes
- Publication number 20220010356
- Publication date Jan 13, 2022
- Life Technologies Corporation
- Albana MIHALI
- G01 - MEASURING TESTING
Information Patent Application
SYSTEMS AND METHODS FOR MULTI-ANALYSIS
- Publication number 20210382077
- Publication date Dec 9, 2021
- Elizabeth A. Holmes
- G01 - MEASURING TESTING
Information Patent Application
Systems and methods for measuring liver enzyme levels in blood
- Publication number 20210363560
- Publication date Nov 25, 2021
- NOVA BIOMEDICAL CORPORATION
- Jianhong Pei
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

involving phosphatase

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Mass spectrometry method for measuring thiamine in body fluid

Systems and methods for multi-analysis

Methods and compositions for synthetic biomarkers

Method of preparation of nanopore and uses thereof

Quinone methide analog signal amplification

Methods for detection of rare subpopulations of cells and highly pu...

Systems and methods for sample use maximization

Enzyme-specific intracellularly-retained red fluorescent probe

Immobilized protein system for rapid and enhanced multiplexed diagn...

Medium for detecting Staphylococcus aureus, sheet for detecting S....

Compositions and methods to detect gastrointestinal disease

Thermostable haloarchaeal inorganic pyrophosphatase

Methods and reagents useful for verification of the integrity of a...

Pharmaceutical compositions for use in the treatment of cardiovascu...

Methods for selecting phosphatase selective and non-selective phosp...

Quinone methide analog signal amplification

Inhibitors and their uses

Inhibitors and their uses

Biomarkers of therapeutic responsiveness

Ultra-high-sensitive assay of protein and nucleic acid and kit, and...

Systems and methods for sample use maximization

Chemical tools for imaging phospholipase D activity

Senescent cell biomarkers

Methods for detecting contaminants in solutions containing glucose...

Inhibitors and their uses

Combination product for detecting target marker

Method for measuring tyrosine phosphatase and tyrosine kinase activity

Cellular assays with a molecular endpoint measured by SAMDI mass sp...

Systems and methods for multi-analysis

Methods involving MenaINV in screening for inhibitors of cancer inv...

Patents Applicationslast 30 patents

IMMOBILIZED PROTEIN SYSTEM FOR RAPID AND ENHANCED MULTIPLEXED DIAGN...

HYBRID CLUSTERING

DIAGNOSTIC ASSAY FOR CLASSIC INBORN GALACTOSEMIA

FUSION PEPTIDES OR PROTEINS, THEIR USE, AND SYSTEMS AND KITS BASED...

METHODS FOR DETECTION OF RARE SUBPOPULATIONS OF CELLS AND HIGHLY PU...

QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION

ASSAY AND METHOD FOR MEASURING ALKALINE PHOSPHATASE ACTIVITY IN URI...

IMMOBILIZED PROTEIN SYSTEM FOR RAPID AND ENHANCED MULTIPLEXED DIAGN...

METHOD AND DEVICE FOR ASSESSING A STATUS OF A WOUND OF A PATIENT

BIOLOGICALLY SYNTHESIZED HYDROXYAPATITE FOR BONE REGENERATION AND T...

METHOD FOR QUANTIFYING ETHANOLAMINE PHOSPHATE, OXIDOREDUCTASE FOR Q...

Compounds for Treating Tauopathies and Restless Leg Syndrome and Me...

METHOD FOR DIAGNOSING AND TREATING BLOOD CANCER

COMPOSITIONS AND METHODS TO DETECT GASTROINTESTINAL DISEASE

VITRO DEVICE TO MEASURE STOOL ALKALINE PHOSPHATEASE

FLUORESCENT PROTEIN BIOSENSOR FOR DETECTION OF KINASE ACTIVITY

Methods and Reagents Useful for Verification of the Integrity of a...

METHODS FOR SELECTING PHOSPHATASE SELECTIVE AND NON-SELECTIVE PHOSP...

BIOMARKERS OF THERAPEUTIC RESPONSIVENESS

SYSTEMS AND METHODS FOR SAMPLE USE MAXIMIZATION

DATA COLLECTION METHOD TO BE USED FOR CLASSIFYING CANCER LIFE

SYSTEMS AND METHODS FOR DETECTING A PATHOGENIC ORGANISM

Senescent Cell Biomarkers

METHODS FOR TREATING DILATED CARDIOMYOPATHY

QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION

Compounds for Treating Tauopathies and Restless Leg Syndrome and Me...

METHOD OF EVALUATING QUALITY OF DEPHOSPHORYLATION REAGENT AND METHO...

Flash and Glow 1,2-Dioxetanes

SYSTEMS AND METHODS FOR MULTI-ANALYSIS

Systems and methods for measuring liver enzyme levels in blood