mammalian

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CPC
C12N2810/85

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CCHEMISTRY METALLURGY C12Biochemistry C12NMICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA C12N2810/00Vectors comprising a targeting moiety

Current Industry

C12N2810/85mammalian

Industries

Patents Grantslast 30 patents

Information Patent Grant
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
- Patent number 11,827,910
- Issue date Nov 28, 2023
- President and Fellows of Harvard College
- Quan Lu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Retroviral and lentiviral vectors
- Patent number 11,814,641
- Issue date Nov 14, 2023
- AUTOLUS LIMITED
- Martin Pulé
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods of delivering anionic agents in vivo using non-viral nanopa...
- Patent number 11,766,486
- Issue date Sep 26, 2023
- NANORA PHARMA INC.
- Satya Prakash
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Replication-competent vesicular stomatitis viruses
- Patent number 11,723,937
- Issue date Aug 15, 2023
- Mayo Foundation for Medical Education and Research
- Kah-Whye Peng
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Systemic delivery of polypeptides
- Patent number 11,701,437
- Issue date Jul 18, 2023
- President and Fellows of Harvard College
- Denitsa M. Milanova
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Retroviral and lentiviral vectors
- Patent number 11,591,613
- Issue date Feb 28, 2023
- AUTOLUS LIMITED
- Vijay Peddareddigari
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Vectors for cloning and expression of proteins, methods and applica...
- Patent number 11,549,119
- Issue date Jan 10, 2023
- ZUMUTOR BIOLOGICS, INC.
- Sohang Chatterjee
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Identification of mutations in herpes simplex virus envelope glycop...
- Patent number 11,419,926
- Issue date Aug 23, 2022
- University of Pittsburgh of the Commonwealth System of Higher Education
- Joseph C. Glorioso
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Mosaic chimeric viral vaccine particle
- Patent number 11,352,416
- Issue date Jun 7, 2022
- The Texas A&M University System
- Waithaka Mwangi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
TAL effector-mediated DNA modification
- Patent number 11,274,294
- Issue date Mar 15, 2022
- Regents of The University of Minnesota
- Daniel F. Voytas
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compositions of nucleic acid-containing nanoparticles for in vivo d...
- Patent number 11,235,071
- Issue date Feb 1, 2022
- The Johns Hopkins University
- Hai-Quan Mao
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Viral nanoparticle multimers
- Patent number 11,193,111
- Issue date Dec 7, 2021
- Case Western Reserve University
- Nicole F. Steinmetz
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Antibodies to endoplasmin and their use
- Patent number 11,078,260
- Issue date Aug 3, 2021
- University of Pittsburgh of the Commonwealth System of Higher Education
- Soldano Ferrone
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Heterologous targeting peptide grafted AAVS
- Patent number 11,014,976
- Issue date May 25, 2021
- University of Massachusetts
- Miguel Sena Esteves
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Delivery of cargo proteins via ARRDC1-mediated microvesicles (ARMMs)
- Patent number 11,001,817
- Issue date May 11, 2021
- President and Fellows of Harvard College
- Quan Lu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Retroviral and lentiviral vectors
- Patent number 10,954,530
- Issue date Mar 23, 2021
- AUTOLUS LIMITED
- Martin Pulé
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Mosaic chimeric viral vaccine particle
- Patent number 10,836,809
- Issue date Nov 17, 2020
- The Texas A&M University System
- Waithaka Mwangi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method of making peptide-tagged PEGylated chitosan nanoparticles
- Patent number 10,799,601
- Issue date Oct 13, 2020
- NANORA PHARMA INC.
- Satya Prakash
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Humanized viral vectors and methods of use thereof
- Patent number 10,787,681
- Issue date Sep 29, 2020
- The Children's Hospital of Philadelphia
- John Fraser Wright
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Use of microvesicles in the treatment of medical conditions
- Patent number 10,731,179
- Issue date Aug 4, 2020
- The General Hospital Corporation
- Johan Karl Olov Skog
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Gene therapy vectors for treatment of Danon disease
- Patent number 10,703,797
- Issue date Jul 7, 2020
- Rocket Pharmaceuticals, Ltd.
- Annahita Keravala
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Packaging cell for making a pseudotyped lentivirus
- Patent number 10,696,984
- Issue date Jun 30, 2020
- California Institute of Technology
- Pin Wang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Replication-competent vesicular stomatitis viruses
- Patent number 10,610,553
- Issue date Apr 7, 2020
- Mayo Foundation for Medical Education and Research
- Kah-Whye Peng
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Targeted gene delivery to non-phagocytic mammalian cells via bacter...
- Patent number 10,583,200
- Issue date Mar 10, 2020
- Engeneic Molecular Delivery Pty Ltd
- Himanshu Brahmbhatt
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Viral vectors encoding multiple highly homologous non-viral polypep...
- Patent number 10,550,176
- Issue date Feb 4, 2020
- Roger Williams Medical Center
- Wen Yang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Viral vectors for the treatment of retinal dystrophy
- Patent number 10,550,404
- Issue date Feb 4, 2020
- Novartis AG
- Vivian Choi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Adeno-associated virus virions with variant capsid and methods of u...
- Patent number 10,494,612
- Issue date Dec 3, 2019
- The Regents of the University of California
- David V. Schaffer
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Recombinant self-assembling protein comprising target-oriented pept...
- Patent number 10,478,638
- Issue date Nov 19, 2019
- Korea University Research and Business Foundation
- Jeewon Lee
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Puma protein expression vector and use thereof in gene therapy
- Patent number 10,449,232
- Issue date Oct 22, 2019
- Hospices Civils de Lyon
- Pierre Miossec
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Use of microvesicles in the treatment of medical conditions
- Patent number 10,421,977
- Issue date Sep 24, 2019
- The General Hospital Corporation
- Johan Karl Olov Skog
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
TEMPERATURE-CONTROLLABLE, RNA IMMUNOTHERAPEUTIC FOR CANCER
- Publication number 20240350605
- Publication date Oct 24, 2024
- Elixirgen Therapeutics, Inc.
- Minoru S.H. KO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DELIVERY OF CAS9 VIA ARRDC1-MEDIATED MICROVESICLES (ARMMS)
- Publication number 20240327478
- Publication date Oct 3, 2024
- President and Fellows of Harvard College
- Quan Lu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CO-EXPRESSION OF CONSTRUCTS AND IMMUNOINHIBITORY COMPOUNDS
- Publication number 20240252625
- Publication date Aug 1, 2024
- NYKODE THERAPEUTICS ASA
- Agnete Brunsvik Fredriksen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS OF DELIVERING ANIONIC AGENTS IN VIVO USING NON-VIRAL NANOPA...
- Publication number 20240156984
- Publication date May 16, 2024
- NANORA PHARMA INC.
- Satya PRAKASH
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Retroviral And Lentiviral Vectors
- Publication number 20240093232
- Publication date Mar 21, 2024
- AUTOLUS LIMITED
- Vijay Peddareddigari
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
REPLICATION-COMPETENT VESICULAR STOMATITIS VIRUSES
- Publication number 20240000873
- Publication date Jan 4, 2024
- Mayo Foundation for Medical Education and Research
- Kah-Whye Peng
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTI-IDIOTYPE COMPOSITIONS AND METHODS OF USE THEREOF
- Publication number 20230357436
- Publication date Nov 9, 2023
- Exuma Biotech Corp.
- Gregory Ian FROST
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CD25 PRE-SELECTIVE COMBINATION ANTI-HIV VECTORS, TARGETING VECTORS,...
- Publication number 20220347316
- Publication date Nov 3, 2022
- The Regents of the University of California
- Joseph Anderson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
TARGETS AND METHODS FOR TREATING EPSTEIN-BARR VIRUS MEDIATED NEUROD...
- Publication number 20220145302
- Publication date May 12, 2022
- Richelle Gayle Cutler
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
GENETICALLY ENGINEERED YEAST YARROWIA LIPOLYTICA AND METHODS FOR PR...
- Publication number 20220127648
- Publication date Apr 28, 2022
- INTEGRATED LIPID BIOFUELS LLC
- Xiaochao XIONG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ENGINEERED ONCOLYTIC VIRUSES EXPRESSING PD-L1 INHIBITORS AND USES T...
- Publication number 20220064672
- Publication date Mar 3, 2022
- University of Southern California
- Siyi CHEN
- C07 - ORGANIC CHEMISTRY
Information Patent Application
LIGAND-DIRECTED TARGETING VECTORS
- Publication number 20220025397
- Publication date Jan 27, 2022
- The Regents of the University of California
- Kouki MORIZONO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Retroviral and Lentiviral Vectors
- Publication number 20210348191
- Publication date Nov 11, 2021
- AUTOLUS LIMITED
- Martin Pulé
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
HETEROLOGOUS TARGETING PEPTIDE GRAFTED AAVS
- Publication number 20210324044
- Publication date Oct 21, 2021
- University of Massachusetts
- Miguel Sena ESTEVES
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
DELIVERY OF CAS9 VIA ARRDC1-MEDIATED MICROVESICLES (ARMMS)
- Publication number 20210261930
- Publication date Aug 26, 2021
- President and Fellows of Harvard College
- Quan Lu
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
VECTORS
- Publication number 20210214748
- Publication date Jul 15, 2021
- AUTOLUS LIMITED
- Simon Thomas
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHODS OF DELIVERING ANIONIC AGENTS IN VIVO USING NON-VIRAL NANOPA...
- Publication number 20210106695
- Publication date Apr 15, 2021
- NANORA PHARMA INC.
- Satya PRAKASH
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF U...
- Publication number 20200231942
- Publication date Jul 23, 2020
- The Regents of the University of California
- David V. Schaffer
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
CD25 PRE-SELECTIVE COMBINATION ANTI-HIV VECTORS, TARGETING VECTORS,...
- Publication number 20200197537
- Publication date Jun 25, 2020
- The Regents of the University of California
- Joseph Anderson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
IDENTIFICATION OF MUTATIONS IN HERPES SIMPLEX VIRUS ENVELOPE GLYCOP...
- Publication number 20200147189
- Publication date May 14, 2020
- University of Pittsburgh of the Commonwealth System of Higher Education
- Joseph C. Glorioso
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
GENE THERAPY VECTORS FOR TREATMENT OF DANON DISEASE
- Publication number 20200148745
- Publication date May 14, 2020
- Rocket Pharmaceuticals, Ltd.
- Annahita KERAVALA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MODIFIED UBE3A GENE FOR A GENE THERAPY APPROACH FOR ANGELMAN SYNDROME
- Publication number 20200113955
- Publication date Apr 16, 2020
- University of South Florida
- Kevin Ron Nash
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MOSAIC CHIMERIC VIRAL VACCINE PARTICLE
- Publication number 20200079838
- Publication date Mar 12, 2020
- THE TEXAS A&M UNIVERSITY SYSTEM
- Waithaka Mwangi
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
HETEROLOGOUS TARGETING PEPTIDE GRAFTED AAVS
- Publication number 20190389934
- Publication date Dec 26, 2019
- University of Massachusetts
- Miguel Sena ESTEVES
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
NON-VIRAL NANOPARTICLE-BASED DELIVERY SYSTEM
- Publication number 20190336616
- Publication date Nov 7, 2019
- NANORA PHARMA INC.
- Satya PRAKASH
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TARGETED GENE DELIVERY FOR DENDRITIC CELL VACCINATION
- Publication number 20190316153
- Publication date Oct 17, 2019
- California Institute of Technology
- Pin Wang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DELIVERY OF CAS9 VIA ARRDC1-MEDIATED MICROVESICLES (ARMMS)
- Publication number 20190241876
- Publication date Aug 8, 2019
- President and Fellows of Harvard College
- Quan Lu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Retroviral And Lentiviral Vectors
- Publication number 20190177746
- Publication date Jun 13, 2019
- AUTOLUS LIMITED
- Vijay Peddareddigari
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS, KITS AND METHODS FOR IN VITRO ANTIGEN PRESENTATION, A...
- Publication number 20190170742
- Publication date Jun 6, 2019
- University of Miami
- Pirouz Mohammad DAFTARIAN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
VECTORS FOR CLONING AND EXPRESSION OF PROTEINS, METHODS AND APPLICA...
- Publication number 20190119691
- Publication date Apr 25, 2019
- Zumutor Biologics, Inc.
- Sohang CHATTERJEE
- C07 - ORGANIC CHEMISTRY

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)

Retroviral and lentiviral vectors

Methods of delivering anionic agents in vivo using non-viral nanopa...

Replication-competent vesicular stomatitis viruses

Systemic delivery of polypeptides

Retroviral and lentiviral vectors

Vectors for cloning and expression of proteins, methods and applica...

Identification of mutations in herpes simplex virus envelope glycop...

Mosaic chimeric viral vaccine particle

TAL effector-mediated DNA modification

Compositions of nucleic acid-containing nanoparticles for in vivo d...

Viral nanoparticle multimers

Antibodies to endoplasmin and their use

Heterologous targeting peptide grafted AAVS

Delivery of cargo proteins via ARRDC1-mediated microvesicles (ARMMs)

Retroviral and lentiviral vectors

Mosaic chimeric viral vaccine particle

Method of making peptide-tagged PEGylated chitosan nanoparticles

Humanized viral vectors and methods of use thereof

Use of microvesicles in the treatment of medical conditions

Gene therapy vectors for treatment of Danon disease

Packaging cell for making a pseudotyped lentivirus

Replication-competent vesicular stomatitis viruses

Targeted gene delivery to non-phagocytic mammalian cells via bacter...

Viral vectors encoding multiple highly homologous non-viral polypep...

Viral vectors for the treatment of retinal dystrophy

Adeno-associated virus virions with variant capsid and methods of u...

Recombinant self-assembling protein comprising target-oriented pept...

Puma protein expression vector and use thereof in gene therapy

Use of microvesicles in the treatment of medical conditions

Patents Applicationslast 30 patents

TEMPERATURE-CONTROLLABLE, RNA IMMUNOTHERAPEUTIC FOR CANCER

DELIVERY OF CAS9 VIA ARRDC1-MEDIATED MICROVESICLES (ARMMS)

CO-EXPRESSION OF CONSTRUCTS AND IMMUNOINHIBITORY COMPOUNDS

METHODS OF DELIVERING ANIONIC AGENTS IN VIVO USING NON-VIRAL NANOPA...

Retroviral And Lentiviral Vectors

REPLICATION-COMPETENT VESICULAR STOMATITIS VIRUSES

ANTI-IDIOTYPE COMPOSITIONS AND METHODS OF USE THEREOF

CD25 PRE-SELECTIVE COMBINATION ANTI-HIV VECTORS, TARGETING VECTORS,...

TARGETS AND METHODS FOR TREATING EPSTEIN-BARR VIRUS MEDIATED NEUROD...

GENETICALLY ENGINEERED YEAST YARROWIA LIPOLYTICA AND METHODS FOR PR...

ENGINEERED ONCOLYTIC VIRUSES EXPRESSING PD-L1 INHIBITORS AND USES T...

LIGAND-DIRECTED TARGETING VECTORS

Retroviral and Lentiviral Vectors

HETEROLOGOUS TARGETING PEPTIDE GRAFTED AAVS

DELIVERY OF CAS9 VIA ARRDC1-MEDIATED MICROVESICLES (ARMMS)

VECTORS

METHODS OF DELIVERING ANIONIC AGENTS IN VIVO USING NON-VIRAL NANOPA...

ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF U...

CD25 PRE-SELECTIVE COMBINATION ANTI-HIV VECTORS, TARGETING VECTORS,...

IDENTIFICATION OF MUTATIONS IN HERPES SIMPLEX VIRUS ENVELOPE GLYCOP...

GENE THERAPY VECTORS FOR TREATMENT OF DANON DISEASE

MODIFIED UBE3A GENE FOR A GENE THERAPY APPROACH FOR ANGELMAN SYNDROME

MOSAIC CHIMERIC VIRAL VACCINE PARTICLE

HETEROLOGOUS TARGETING PEPTIDE GRAFTED AAVS

NON-VIRAL NANOPARTICLE-BASED DELIVERY SYSTEM

TARGETED GENE DELIVERY FOR DENDRITIC CELL VACCINATION

DELIVERY OF CAS9 VIA ARRDC1-MEDIATED MICROVESICLES (ARMMS)

Retroviral And Lentiviral Vectors

COMPOSITIONS, KITS AND METHODS FOR IN VITRO ANTIGEN PRESENTATION, A...

VECTORS FOR CLONING AND EXPRESSION OF PROTEINS, METHODS AND APPLICA...