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Manipulation of the nucleic acid to modify its expression pattern
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A61K48/0066
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PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases Gene therapy
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A61K48/0066
Manipulation of the nucleic acid to modify its expression pattern
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Patents Grants
last 30 patents
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Patent Grant
Optimized promoter sequences, intron-free expression constructs and...
Patent number
12,290,574
Issue date
May 6, 2025
SPARK THERAPEUTICS, INC.
Xavier Anguela
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Gene therapy for haploinsufficiency
Patent number
12,285,496
Issue date
Apr 29, 2025
The Regents of the University of California
Nadav Ahituv
A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
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Patent Grant
Self-complementary adeno-associated virus vector and its use in tre...
Patent number
12,285,497
Issue date
Apr 29, 2025
Research Institute at Nationwide Children's Hospital
Louise Rodino-Klapac
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Methods and compositions for increasing protein expression and/or t...
Patent number
12,281,314
Issue date
Apr 22, 2025
Case Western Reserve University
Jeffery M. Coller
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Lipid nanoparticle formulations for delivery of MRNA
Patent number
12,280,117
Issue date
Apr 22, 2025
Translate Bio, Inc.
Frank DeRosa
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
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Patent Grant
Recombinant adenoviruses carrying transgenes
Patent number
12,280,123
Issue date
Apr 22, 2025
EpicentRx, Inc.
Christopher Larson
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Methods of reducing FUS/TLS- or TDP-43-mediated neuronal cytotoxici...
Patent number
12,275,764
Issue date
Apr 15, 2025
Brandeis University
Greg Petsko
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Guide RNA that targets a mutant human inosine monophosphate deyhydr...
Patent number
12,274,758
Issue date
Apr 15, 2025
EMENDOBIO INC.
Lior Izhar
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Compositions and methods for modulating Myc target protein 1
Patent number
12,263,233
Issue date
Apr 1, 2025
Washington University
Kyunghee Choi
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Optimized CLN1 genes and expression cassettes and their use
Patent number
12,257,322
Issue date
Mar 25, 2025
The University of North Carolina at Chapel Hill
Steven Gray
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Granulocyte colony-stimulating factor (GCSF) gene therapy for treat...
Patent number
12,246,074
Issue date
Mar 11, 2025
CHS Pharma Inc.
Jang-Yen Wu
C07 - ORGANIC CHEMISTRY
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Patent Grant
Modified ligand-gated ion channels and methods of use
Patent number
12,247,064
Issue date
Mar 11, 2025
Howard Hughes Medical Institute
Scott Sternson
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
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Patent Grant
Adeno-associated virus factor VIII vectors
Patent number
12,239,692
Issue date
Mar 4, 2025
Biomarin Pharmaceutical Inc.
Peter Cameron Colosi
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Hepatitis B vaccines and uses of the same
Patent number
12,234,261
Issue date
Feb 25, 2025
PRECIGEN, INC.
Douglas E. Brough
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Therapeutic applications of CPF1-based genome editing
Patent number
12,214,056
Issue date
Feb 4, 2025
Duke University
Charles A. Gersbach
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
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Patent Grant
Pharmaceutical composition for prevention or treatment of heart fai...
Patent number
12,215,362
Issue date
Feb 4, 2025
BETHPHAGEN INC.
Tae Hwan Kwak
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Engineering the RRM2 subunit of ribonucleotide reductase to resist...
Patent number
12,208,133
Issue date
Jan 28, 2025
University of Washington
Michael Regnier
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Compositions and methods for promoting homology directed repair
Patent number
12,201,699
Issue date
Jan 21, 2025
Editas Medicine, Inc.
Cecilia Cotta-Ramusino
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Materials and methods for treatment of hereditary haemochromatosis
Patent number
12,186,406
Issue date
Jan 7, 2025
CRISPR THERAPEUTICS AG
Roman Lvovitch Bogorad
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Recombinogenic nucleic acid strands in situ
Patent number
12,178,884
Issue date
Dec 31, 2024
SNIPR TECHNOLOGIES LIMITED
Jasper Clube
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Cells lacking B2M surface expression and methods for allogeneic adm...
Patent number
12,180,263
Issue date
Dec 31, 2024
President and Fellows of Harvard College
Chad A. Cowan
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Gene therapy for ciliopathies
Patent number
12,171,794
Issue date
Dec 24, 2024
UCL BUSINESS LTD
Philip Beales
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Guide RNA that targets a mutant human guanylate cyclase 2A allele
Patent number
12,168,062
Issue date
Dec 17, 2024
EMENDOBIO INC.
Lior Izhar
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Chimeric protein and related genic transfer technology
Patent number
12,138,319
Issue date
Nov 12, 2024
Lucio Pastore
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Development of optimized recombinant expression construct
Patent number
12,134,776
Issue date
Nov 5, 2024
G&P BIOSCIENCE CO., LTD.
Seong Hyun Ho
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Immunostimulating vector system
Patent number
12,133,898
Issue date
Nov 5, 2024
Provecs Medical GmbH
Frank Schnieders
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Grant
Coronavirus vaccine
Patent number
12,133,899
Issue date
Nov 5, 2024
BIONTECH SE
Ugur Sahin
B82 - NANO-TECHNOLOGY
Information
Patent Grant
Polynucleotides encoding JAGGED1 for the treatment of Alagille synd...
Patent number
12,128,113
Issue date
Oct 29, 2024
ModernaTX, Inc.
Kerry Benenato
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Grant
Materials and methods for treatment of usher syndrome type 2A and/o...
Patent number
12,122,998
Issue date
Oct 22, 2024
CRISPR THERAPEUTICS AG
Mariacarmela Allocca
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Grant
Base editing of ANGPTL3 and methods of using same for treatment of...
Patent number
12,115,230
Issue date
Oct 15, 2024
Verve Therapeutics, Inc.
Alexandra Chadwick
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Patents Applications
last 30 patents
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Patent Application
METHODS USING SURFACE-EXPRESSIBLE ACTIVATABLE EPITOPES TO LOCALIZE...
Publication number
20250144249
Publication date
May 8, 2025
EARLI Inc.
Alex HARWIG
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
NON-IMMUNOGENIC CIRCULAR, NON-VIRAL DNA VECTORS
Publication number
20250146016
Publication date
May 8, 2025
Rampart Bioscience, Inc.
Jeffrey S. Bartlett
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
GENE THERAPY FOR ARRHYTHMOGENIC CARDIOMYOPATHY
Publication number
20250144245
Publication date
May 8, 2025
Ginkgo BioWorks, Inc.
John Graef
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
SPLICE-SWITCHING OLIGONUCLEOTIDES AND METHODS OF USE
Publication number
20250136995
Publication date
May 1, 2025
DUKE UNIVERSITY
Jennifer Freedman
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
NOVEL IMMUNOSTIMULATING VECTOR SYSTEM
Publication number
20250127931
Publication date
Apr 24, 2025
Provecs Medical GmbH
Frank Schnieders
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
MATERIALS AND METHODS FOR TREATMENT OF USHER SYNDROME TYPE 2A AND/O...
Publication number
20250122497
Publication date
Apr 17, 2025
CRISPR Therapeutics AG
Mariacarmela ALLOCCA
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
NUCLEIC ACID ENCODING RRM2 SUBUNIT OF RIBONUCLEOTIDE REDUCTASE TO R...
Publication number
20250121038
Publication date
Apr 17, 2025
University of Washington
Michael REGNIER
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
THERAPEUTIC APPLICATIONS OF CPF1-BASED GENOME EDITING
Publication number
20250114482
Publication date
Apr 10, 2025
DUKE UNIVERSITY
Charles A. Gersbach
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE
Publication number
20250109398
Publication date
Apr 3, 2025
ASKLEPIOS BIOPHARMACEUTICAL, INC.
Anna TRETIAKOVA
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
NON-TOXIC HSV VECTORS FOR EFFICIENT GENE DELIVERY APPLICATIONS AND...
Publication number
20250109411
Publication date
Apr 3, 2025
University of Pittsburgh of the Commonwealth System of Higher Education
Joseph C. Glorioso
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
CIRCULAR RNA VACCINES AND METHODS OF USE THEREOF
Publication number
20250108134
Publication date
Apr 3, 2025
Beijing Changping Laboratory
Wensheng WEI
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
COMPOSITION AND METHODS FOR MODULATION OF ELOVL2
Publication number
20250099553
Publication date
Mar 27, 2025
YouHealth Biotech, Limited
Kang ZHANG
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
SYSTEMIC ADMINISTRATION OF CIRCULAR RNA POLYNUCLEOTIDES ENCODING MU...
Publication number
20250099621
Publication date
Mar 27, 2025
Orna Therapeutics, Inc.
Allen T. Horhota
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
METHODS AND COMPOSITIONS FOR THE TREATMENT OF RARE DISEASES
Publication number
20250099624
Publication date
Mar 27, 2025
Sangamo Therapeutics, Inc.
Michael C. HOLMES
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
TREATMENT OF INTERVERTEBRAL DISC DEGENERATION
Publication number
20250090635
Publication date
Mar 20, 2025
Kolon TissueGene, Inc.
Moon Jong Noh
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF
Publication number
20250090692
Publication date
Mar 20, 2025
ModernaTX, Inc.
Jason P. SCHRUM
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
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Patent Application
ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR RESTORING PAH GENE FUNCTION...
Publication number
20250090691
Publication date
Mar 20, 2025
HOMOLOGY MEDICINES, INC.
Jason Boke WRIGHT
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
POLYNUCLEOTIDES ENCODING GLUCOSE-6-PHOSPHATASE FOR THE TREATMENT OF...
Publication number
20250090684
Publication date
Mar 20, 2025
ModernaTX, Inc.
Husain Attarwala
A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information
Patent Application
GENE EDITING OF CAR-T CELLS FOR THE TREATMENT OF T CELL MALIGNANCIE...
Publication number
20250082785
Publication date
Mar 13, 2025
Washington University
John F. DiPersio
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PRO...
Publication number
20250074962
Publication date
Mar 6, 2025
ModernaTX, Inc.
Antonin DE FOUGEROLLES
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
COMPOSITIONS AND METHODS FOR DELIVERY OF AGENTS TO INNER EAR
Publication number
20250073354
Publication date
Mar 6, 2025
University of Rochester
Maiken Nedergaard
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
NUCLEIC ACID EXPRESSION PLATFORM WITH INCREASED EXPRESSION EFFICIENCY
Publication number
20250064985
Publication date
Feb 27, 2025
SML BIOPHARM CO., LTD.
Jae Hwan Nam
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
OPTIMIZED POLYNUCLEOTIDES FOR PROTEIN EXPRESSION
Publication number
20250064986
Publication date
Feb 27, 2025
PRECISION BIOSCIENCES, INC.
Jason Richard Harris
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
GENE THERAPY FOR CILIOPATHIES
Publication number
20250057899
Publication date
Feb 20, 2025
UCL Business LTD
Philip Beales
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
Compositions and Methods for Treatment of Ocular Disease Associated...
Publication number
20250057987
Publication date
Feb 20, 2025
4D MOLECULAR THERAPEUTICS INC.
Christian BURNS
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
Guide RNA That Targets A Mutant Human Guanylate Cyclase 2A Allele
Publication number
20250057988
Publication date
Feb 20, 2025
EmendoBio Inc.
Lior Izhar
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
GENE THERAPY FOR LAMIN A-ASSOCIATED DEFICIENCIES
Publication number
20250049949
Publication date
Feb 13, 2025
The Trustees of the University of Pennsylvania
Christian Hinderer
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information
Patent Application
ANTI-TFR:ACID SPHINGOMYELINASE FOR TREATMENT OF ACID SPHINGOMYELINA...
Publication number
20250049896
Publication date
Feb 13, 2025
Regeneron Pharmaceuticals, Inc.
Maria Praggastis
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
SCALABLE AND HIGH-PURITY CELL-FREE SYNTHESIS OF CLOSED-ENDED DNA VE...
Publication number
20250049961
Publication date
Feb 13, 2025
GENERATION BIO CO.
Russell Monds
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
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Patent Application
ENGINEERED MUSCLE TARGETING COMPOSITIONS
Publication number
20250051800
Publication date
Feb 13, 2025
THE BROAD INSTITUTE, INC.
Pardis SABETI
C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...