Reactions of nucleic acids characterised by

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Patents Grantslast 30 patents

Information Patent Grant
DNA-tagged methanol responsive polymer for single-stranded nucleic...
- Patent number 12,173,351
- Issue date Dec 24, 2024
- Dana-Farber Cancer Institute, Inc.
- Elisha Krieg
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Multiplex amplification detection assay II
- Patent number 12,173,362
- Issue date Dec 24, 2024
- EXACT Sciences Corporation
- Hatim T. Allawi
- C01 - INORGANIC CHEMISTRY
Information Patent Grant
Method of amplifying circular DNA
- Patent number 12,157,915
- Issue date Dec 3, 2024
- Moderna Enzymatics Co., Ltd.
- Masayuki Su'etsugu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Gene therapy vector contamination assay
- Patent number 12,152,281
- Issue date Nov 26, 2024
- Trizell Ltd.
- Hanna Peltonen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods of RNA amplification
- Patent number 12,139,755
- Issue date Nov 12, 2024
- Asuragen, Inc.
- Gary J. Latham
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Automated method for performing an assay
- Patent number 12,128,414
- Issue date Oct 29, 2024
- MESA BIOTECH LLC
- Mark Nowakowski
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Determining linear and circular forms of circulating nucleic acids
- Patent number 12,098,429
- Issue date Sep 24, 2024
- The Chinese University of Hong Kong
- Yuk-Ming Dennis Lo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for detecting agglutination and compositions for use in pra...
- Patent number 12,054,768
- Issue date Aug 6, 2024
- The Regents of the University of California
- Peter Robinson
- G01 - MEASURING TESTING
Information Patent Grant
Methods for assembling nucleic acids
- Patent number 12,018,316
- Issue date Jun 25, 2024
- Telesis Bio Inc.
- John E. Gill
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method and device for digital PCR measurement
- Patent number 12,018,319
- Issue date Jun 25, 2024
- Hitachi, Ltd.
- Junko Tanaka
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Methods and compositions for isolating asymmetric nucleic acid comp...
- Patent number 12,012,631
- Issue date Jun 18, 2024
- Pacific Biosciences of California, Inc.
- Lei Sun
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for targeted nucleic acid sequence enrichment with applicat...
- Patent number 12,006,532
- Issue date Jun 11, 2024
- University of Washington
- Scott R. Kennedy
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Microfluidic device and method for the nanostructure sequencing of...
- Patent number 11,986,823
- Issue date May 21, 2024
- Robert Bosch GmbH
- Franz Laermer
- G01 - MEASURING TESTING
Information Patent Grant
Methods for constructing copies of nucleic acid molecules
- Patent number 11,981,961
- Issue date May 14, 2024
- Vastogen, Inc.
- Dimitra Tsavachidou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and compositions for generating asymmetrically-tagged nucle...
- Patent number 11,976,319
- Issue date May 7, 2024
- Pacific Biosciences of California, Inc.
- Joan Wilson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Exponential base-greater-than-2 nucleic acid amplification
- Patent number 11,952,621
- Issue date Apr 9, 2024
- CEPHEID
- Russell Higuchi
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Development of simple sequence repeat (SSR) core primer group based...
- Patent number 11,926,869
- Issue date Mar 12, 2024
- INSTITUTE OF HORTICULTURE RESEARCH, ANHUI ACADEMY OF AGRICULTURAL SCIENCE
- Gaihua Qin
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Systems and methods for processing optically tagged beads
- Patent number 11,920,183
- Issue date Mar 5, 2024
- 10X GENOMICS, INC.
- Rajiv Bharadwaj
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods and kits for amplification of double stranded DNA
- Patent number 11,920,189
- Issue date Mar 5, 2024
- 4BASEBIO SL
- Ángel Joaquin Picher Serantes
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods of detecting listeria from an environmental sample
- Patent number 11,905,566
- Issue date Feb 20, 2024
- Neogen Corporation
- John Nelson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Increasing capture efficiency of spatial assays
- Patent number 11,898,205
- Issue date Feb 13, 2024
- 10X GENOMICS, INC.
- Felice Alessio Bava
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Isothermal amplification components and processes
- Patent number 11,884,969
- Issue date Jan 30, 2024
- NAT DIAGNOSTICS, INC.
- Andrew P. Miller
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Linked ligation
- Patent number 11,879,151
- Issue date Jan 23, 2024
- NCAN Genomics, Inc.
- Andrea Marziali
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Analysis of chromatin using a nicking enzyme
- Patent number 11,840,741
- Issue date Dec 12, 2023
- New England Biolabs, Inc.
- Chaithanya Ponnaluri
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method of fluorescent detection of isothermal loop-mediated amplifi...
- Patent number 11,827,923
- Issue date Nov 28, 2023
- DiaSorin S.p.A.
- Giulia Minnucci
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for diagnosing cholangiocarcinoma via bacterial metagenomic...
- Patent number 11,827,939
- Issue date Nov 28, 2023
- MD HEALTHCARE INC.
- Yoon-Keun Kim
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Mutant polymerases and uses thereof
- Patent number 11,814,655
- Issue date Nov 14, 2023
- DNA Polymerase Technology, Inc.
- Wayne M. Barnes
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Complex of LNA probe and graphene oxide and nucleic acid detection...
- Patent number 11,814,672
- Issue date Nov 14, 2023
- Korea Research Institute of Chemical Technology
- Jieon Lee
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Thermostable viral reverse transcriptase
- Patent number 11,807,667
- Issue date Nov 7, 2023
- QIAGEN BEVERLY, LLC.
- Thomas William Schoenfeld
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for identifying gene fusions by circle cDNA amplification
- Patent number 11,802,282
- Issue date Oct 31, 2023
- XBF LLC
- Xiao Bing Wang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
METHODS FOR AMPLIFICATION OF NUCLEIC ACIDS WITH ENDONUCLEASE-MEDIAT...
- Publication number 20250002984
- Publication date Jan 2, 2025
- DNAe Diagnostics Limited
- Kamil Andrzej LIPINSKI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DETERMINING LINEAR AND CIRCULAR FORMS OF CIRCULATING NUCLEIC ACIDS
- Publication number 20240410023
- Publication date Dec 12, 2024
- The Chinese University of Hong Kong
- Yuk-Ming Dennis Lo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS FOR TARGETED NUCLEIC ACID SEQUENCE ENRICHMENT WITH APPLICAT...
- Publication number 20240401108
- Publication date Dec 5, 2024
- University of Washington
- Scott R. Kennedy
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SYSTEMS AND METHODS FOR CLONAL REPLICATION AND AMPLIFICATION OF NUC...
- Publication number 20240368682
- Publication date Nov 7, 2024
- REDVAULT BIOSCIENCES LP
- Michael L. METZKER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SYSTEMS AND METHODS FOR PROCESSING OPTICALLY TAGGED BEADS
- Publication number 20240360493
- Publication date Oct 31, 2024
- 10X Genomics, Inc.
- Rajiv Bharadwaj
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS FOR CONSTRUCTING COPIES OF NUCLEIC ACID MOLECULES
- Publication number 20240360498
- Publication date Oct 31, 2024
- Vastogen, Inc.
- Dimitra Tsavachidou
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND KITS FOR AMPLIFICATION OF DOUBLE STRANDED DNA
- Publication number 20240336963
- Publication date Oct 10, 2024
- 4BASEBIO SL
- Ángel Joaquin PICHER SERANTES
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DNA ARRAY
- Publication number 20240301486
- Publication date Sep 12, 2024
- Complete Genomics, Inc.
- Radoje Drmanac
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NUCLEIC ACID DETECTION AND QUANTIFICATION METHOD AND COMPOSITIONS
- Publication number 20240294993
- Publication date Sep 5, 2024
- MICROBIAL DISCOVERY GROUP, LLC
- Michael R. KING
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods for Assembling Nucleic Acids
- Publication number 20240287581
- Publication date Aug 29, 2024
- Telesis Bio, Inc.
- John E. Gill
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TISSUE SPATIAL OMICS
- Publication number 20240263169
- Publication date Aug 8, 2024
- Digital Biology Inc.
- Jocelyn KISHI
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DNA CONCATEMERS ON A SURFACE
- Publication number 20240263230
- Publication date Aug 8, 2024
- Complete Genomics, Inc.
- Radoje Drmanac
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ISOTHERMAL AMPLIFICATION COMPONENTS AND PROCESSES
- Publication number 20240209426
- Publication date Jun 27, 2024
- NAT DIAGNOSTICS, INC.
- Andrew P. Miller
- G01 - MEASURING TESTING
Information Patent Application
DNA-BARCODED ANTIGEN MULTIMERS AND METHOD OF USE THEREOF
- Publication number 20240191298
- Publication date Jun 13, 2024
- Board of Regents, The University of Texas System
- Ning JIANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
INCREASING CAPTURE EFFICIENCY OF SPATIAL ASSAYS
- Publication number 20240182968
- Publication date Jun 6, 2024
- 10X Genomics, Inc.
- Felice Alessio Bava
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Analysis of Chromatin Using a Nicking Enzyme
- Publication number 20240158870
- Publication date May 16, 2024
- New England Biolabs, Inc.
- Chaithanya Ponnaluri
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD OF DETECTING MULTIPLE FORMS OF AN ANALYTE
- Publication number 20240124923
- Publication date Apr 18, 2024
- Gen-Probe Incorporated
- Patrick L. PETERSON
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SYSTEM FOR PERFORMING NUCLEIC ACID AMPLIFICATION ASSAYS
- Publication number 20240093277
- Publication date Mar 21, 2024
- Gen-Probe Incorporated
- Jennifer L. TIDD
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS FOR DETERMINING A NUCLEOTIDE SEQUENCE CONTIGUOUS TO A KNOWN...
- Publication number 20240076727
- Publication date Mar 7, 2024
- The General Hospital Corporation
- Anthony John Iafrate
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods for Detecting Site-Specific and Spurious Genomic Deaminatio...
- Publication number 20240076713
- Publication date Mar 7, 2024
- The General Hospital Corporation
- J. Keith Joung
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Automated Method For Performing An Assay
- Publication number 20240076724
- Publication date Mar 7, 2024
- Mesa Biotech, Inc.
- Mark Nowakowski
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
LINKED LIGATION
- Publication number 20240052403
- Publication date Feb 15, 2024
- NCAN Genomics, Inc.
- Andrea Marziali
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD OF PERFORMING A LAB DEVELOPED TEST
- Publication number 20240043916
- Publication date Feb 8, 2024
- Gen-Probe Incorporated
- Jennifer L. TIDD
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MUTANT POLYMERASES AND USES THEREOF
- Publication number 20240026315
- Publication date Jan 25, 2024
- DNA Polymerase Technology, Inc.
- Wayne M. Barnes
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR AMPLIFYING FREE NUCLEIC ACIDS DIRECTLY FROM ONE DROP OF...
- Publication number 20240002903
- Publication date Jan 4, 2024
- Kuo Ping CHIU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
WHOLE TRANSCRIPTOME ANALYSIS IN SINGLE CELLS
- Publication number 20230416804
- Publication date Dec 28, 2023
- Roche Sequencing Solutions, Inc.
- Sedide Ozturk
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ASSAY METHODS
- Publication number 20230407380
- Publication date Dec 21, 2023
- MESO SCALE TECHNOLOGIES, LLC.
- Eli N. GLEZER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
OLIGONUCLEOTIDES ASSOCIATED WITH ANTIBODIES
- Publication number 20230348975
- Publication date Nov 2, 2023
- Becton, Dickinson and Company
- Eleen Shum
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Targeted cell free nucleic acid analysis
- Publication number 20230323476
- Publication date Oct 12, 2023
- NantHealth Labs, Inc.
- Shahrooz Rabizadeh
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS AND USES OF INFLAMMATORY BOWEL DISEASE BIOMARKERS
- Publication number 20230313305
- Publication date Oct 5, 2023
- Washington University
- Thaddeus Stappenbeck
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Reactions of nucleic acids characterised by

Industry

Parent Industries

Current Industry

Sub Industries

Patents Grantslast 30 patents

DNA-tagged methanol responsive polymer for single-stranded nucleic...

Multiplex amplification detection assay II

Method of amplifying circular DNA

Gene therapy vector contamination assay

Methods of RNA amplification

Automated method for performing an assay

Determining linear and circular forms of circulating nucleic acids

Methods for detecting agglutination and compositions for use in pra...

Methods for assembling nucleic acids

Method and device for digital PCR measurement

Methods and compositions for isolating asymmetric nucleic acid comp...

Methods for targeted nucleic acid sequence enrichment with applicat...

Microfluidic device and method for the nanostructure sequencing of...

Methods for constructing copies of nucleic acid molecules

Methods and compositions for generating asymmetrically-tagged nucle...

Exponential base-greater-than-2 nucleic acid amplification

Development of simple sequence repeat (SSR) core primer group based...

Systems and methods for processing optically tagged beads

Methods and kits for amplification of double stranded DNA

Methods of detecting listeria from an environmental sample

Increasing capture efficiency of spatial assays

Isothermal amplification components and processes

Linked ligation

Analysis of chromatin using a nicking enzyme

Method of fluorescent detection of isothermal loop-mediated amplifi...

Method for diagnosing cholangiocarcinoma via bacterial metagenomic...

Mutant polymerases and uses thereof

Complex of LNA probe and graphene oxide and nucleic acid detection...

Thermostable viral reverse transcriptase

Method for identifying gene fusions by circle cDNA amplification

Patents Applicationslast 30 patents

METHODS FOR AMPLIFICATION OF NUCLEIC ACIDS WITH ENDONUCLEASE-MEDIAT...

DETERMINING LINEAR AND CIRCULAR FORMS OF CIRCULATING NUCLEIC ACIDS

METHODS FOR TARGETED NUCLEIC ACID SEQUENCE ENRICHMENT WITH APPLICAT...

SYSTEMS AND METHODS FOR CLONAL REPLICATION AND AMPLIFICATION OF NUC...

SYSTEMS AND METHODS FOR PROCESSING OPTICALLY TAGGED BEADS

METHODS FOR CONSTRUCTING COPIES OF NUCLEIC ACID MOLECULES

METHODS AND KITS FOR AMPLIFICATION OF DOUBLE STRANDED DNA

DNA ARRAY

NUCLEIC ACID DETECTION AND QUANTIFICATION METHOD AND COMPOSITIONS

Methods for Assembling Nucleic Acids

TISSUE SPATIAL OMICS

DNA CONCATEMERS ON A SURFACE

ISOTHERMAL AMPLIFICATION COMPONENTS AND PROCESSES

DNA-BARCODED ANTIGEN MULTIMERS AND METHOD OF USE THEREOF

INCREASING CAPTURE EFFICIENCY OF SPATIAL ASSAYS

Analysis of Chromatin Using a Nicking Enzyme

METHOD OF DETECTING MULTIPLE FORMS OF AN ANALYTE

SYSTEM FOR PERFORMING NUCLEIC ACID AMPLIFICATION ASSAYS

METHODS FOR DETERMINING A NUCLEOTIDE SEQUENCE CONTIGUOUS TO A KNOWN...

Methods for Detecting Site-Specific and Spurious Genomic Deaminatio...

Automated Method For Performing An Assay

LINKED LIGATION

METHOD OF PERFORMING A LAB DEVELOPED TEST

MUTANT POLYMERASES AND USES THEREOF

METHOD FOR AMPLIFYING FREE NUCLEIC ACIDS DIRECTLY FROM ONE DROP OF...

WHOLE TRANSCRIPTOME ANALYSIS IN SINGLE CELLS

ASSAY METHODS

OLIGONUCLEOTIDES ASSOCIATED WITH ANTIBODIES

Targeted cell free nucleic acid analysis

METHODS AND USES OF INFLAMMATORY BOWEL DISEASE BIOMARKERS