Serine endopeptidases (3.4.21)

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CPC
C12N9/6408

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CCHEMISTRY METALLURGY C12Biochemistry C12NMICRO-ORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA C12N9/00Enzymes Proenzymes Compositions thereof Processes for preparing, activating, inhibiting, separating or purifying enzymes

Current Industry

C12N9/6408Serine endopeptidases (3.4.21)

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Patents Grantslast 30 patents

Information Patent Grant
Recombinant amebocyte lysate and uses thereof
- Patent number 12,158,471
- Issue date Dec 3, 2024
- Charles River Laboratories, Inc.
- Norman R. Wainwright
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Recombinant Factor C and method for producing the same, and method...
- Patent number 11,959,109
- Issue date Apr 16, 2024
- Seikagaku Corporation
- Hikaru Mizumura
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Recombinant Factor C and method for producing the same, and method...
- Patent number 11,236,318
- Issue date Feb 1, 2022
- Seikagaku Corporation
- Hikaru Mizumura
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for recombinant production of horseshoe crab Factor C protei...
- Patent number 11,098,298
- Issue date Aug 24, 2021
- BIOMÉRIEUX DEUTSCHLAND GMBH
- Bernd Buchberger
- G01 - MEASURING TESTING
Information Patent Grant
Optimization of the expression of serine proteases in host cells
- Patent number 11,091,751
- Issue date Aug 17, 2021
- BRAIN Biotech AG
- Alexander Pelzer
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Recombinant factor C and method for producing the same, and method...
- Patent number 10,982,202
- Issue date Apr 20, 2021
- Seikagaku Corporation
- Hikaru Mizumura
- G01 - MEASURING TESTING
Information Patent Grant
Methods of isolating and detecting metal ions from proteins
- Patent number 10,859,555
- Issue date Dec 8, 2020
- ZEPTO LIFE TECHNOLOGY, LLC
- Joy Sinha
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Enhanced fermentation
- Patent number 10,676,728
- Issue date Jun 9, 2020
- BASF SE
- Max Fabian Felle
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Protease variants and polynucleotides encoding same
- Patent number 10,400,230
- Issue date Sep 3, 2019
- Novozymes A/S
- Frank W. Rasmussen
- C11 - ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES FATTY ACIDS...
Information Patent Grant
Anti-GPIIB/IIIA antibodies or uses thereof
- Patent number 10,364,288
- Issue date Jul 30, 2019
- Biogen MA Inc.
- Joe Salas
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Protease for wound conditioning and skin care
- Patent number RE47528
- Issue date Jul 23, 2019
- B.R.A.I.N. Biotechnology Research and Information Network AG
- Frank Niehaus
Information Patent Grant
Method for recombinant production of horseshoe crab factor C protei...
- Patent number 10,323,238
- Issue date Jun 18, 2019
- Hyglos Invest GmbH
- Bernd Buchberger
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Milling process
- Patent number 10,308,967
- Issue date Jun 4, 2019
- Novozymes A/S
- Zhen Long
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Grant
Recombinant Factor C and method for producing the same, and method...
- Patent number 10,144,923
- Issue date Dec 4, 2018
- Seikagaku Corporation
- Hikaru Mizumura
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Variant AAV and compositions, methods and uses for gene transfer to...
- Patent number 9,840,719
- Issue date Dec 12, 2017
- The Children's Hospital of Philadelphia
- Katherine High
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Method for recombinant production of horseshoe crab factor C protei...
- Patent number 9,725,706
- Issue date Aug 8, 2017
- Hyglos Invest GmbH
- Bernd Buchberger
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Protease screening methods and proteases identified thereby
- Patent number 9,290,757
- Issue date Mar 22, 2016
- Catalyst Biosciences, Inc.
- Edwin L. Madison
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Expression vector for animal cells including CSP-B 5′-SAR factor an...
- Patent number 9,228,218
- Issue date Jan 5, 2016
- Chong Kun Dang Pharmaceutical Corp.
- Yeo-Wook Koh
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Peptides, compositions, and uses thereof
- Patent number 8,883,740
- Issue date Nov 11, 2014
- Fundacao de Amparoa Pesquisa do Estado de Sao Paulo-Fapesp
- Janaina De Souza Ventura
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Protease screening methods and proteases identified thereby
- Patent number 8,663,633
- Issue date Mar 4, 2014
- Torrey Pines Institute for Molecular Studies
- Edwin L. Madison
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Protease for wound conditioning and skin care
- Patent number 8,623,810
- Issue date Jan 7, 2014
- B.R.A.I.N. Biotechnology Research and Information Network AG
- Frank Niehaus
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method of enhancing recombinant protein production
- Patent number 8,329,429
- Issue date Dec 11, 2012
- Induce Biologics Inc.
- Sean A. F. Peel
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Methods for detecting virulent Plasmodium, for evaluating Plasmodiu...
- Patent number 8,329,883
- Issue date Dec 11, 2012
- Institut Pasteur
- Jean-Christophe Barale
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Protease screening methods and proteases identified thereby
- Patent number 8,211,428
- Issue date Jul 3, 2012
- Torrey Pines Institute for Molecular Studies
- Edwin L. Madison
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Selective enzymatic amidation of C-terminal esters or acids of pept...
- Patent number 8,124,372
- Issue date Feb 28, 2012
- N.V. Organon
- Ivo Franci Eggen
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods of reducing a viral infection and kits therefore
- Patent number 8,088,571
- Issue date Jan 3, 2012
- Institut de Recherches Cliniques de Montreal
- Nabil G. Seidah
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Modified enteropeptidase protein
- Patent number 8,013,137
- Issue date Sep 6, 2011
- National University Corporation Hokkaido University
- Katsueki Ogiwara
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Methods for detecting virulent Plasmodium, for evaluating Plasmodiu...
- Patent number 8,012,706
- Issue date Sep 6, 2011
- Institut Pasteur
- Jean-Christophe Barale
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Polypeptides recognized by anti-Trichinella antibodies, and uses th...
- Patent number 7,993,860
- Issue date Aug 9, 2011
- Institut National de la Recherche Agronomique
- Pascal Boireau
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Protein having prolyl oligopeptidase activity, nucleic acid encodin...
- Patent number 7,960,162
- Issue date Jun 14, 2011
- Food Industry Research and Development Institute
- Jen-Tao Chen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Patents Applicationslast 30 patents

Information Patent Application
FURIN-CLEAVABLE DELIVERY CONSTRUCTS
- Publication number 20250099599
- Publication date Mar 27, 2025
- Thornhill Therapeutics, Inc.
- Thomas Carl Hunter
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
REAGENT FOR MEASURING B-GLUCAN, METHOD FOR PRODUCING SAME AND USE T...
- Publication number 20250044296
- Publication date Feb 6, 2025
- Seikagaku Corporation
- Hikaru MIZUMURA
- G01 - MEASURING TESTING
Information Patent Application
ENGINEERED ALPHA-GALACTOSIDASE A (A-GAL A) PEPTIDES AND FUNCTIONAL...
- Publication number 20240360431
- Publication date Oct 31, 2024
- Sichuan Real&Best Biotech Co., Ltd.
- Biao DONG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Modified Cell Targeting Tumor ECM and Cellular Therapy thereof
- Publication number 20240307442
- Publication date Sep 19, 2024
- Innovative Cellular Therapeutics Holdings, Ltd.
- Wei DING
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
COMPOSITION AND METHOD FOR TREATING HEMOPHILIA B
- Publication number 20240287490
- Publication date Aug 29, 2024
- INSPIRAR LIMITED
- Zhongdong SHI
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
DETERGENT COMPOSITIONS CONTAINING ENZYMES
- Publication number 20240263162
- Publication date Aug 8, 2024
- The Procter & Gamble Company
- Lilia Maria Babe
- C11 - ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES FATTY ACIDS...
Information Patent Application
METHOD FOR INCREASING THE EXTRACTION RATE OF CHONDROITIN SULFATE PR...
- Publication number 20240247293
- Publication date Jul 25, 2024
- GUANGDONG OCEAN UNIVERSITY
- Saiyi ZHONG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ENZYMES, MICRO-ORGANISMS AND USES THEREOF, AND A METHOD OF DEGRADIN...
- Publication number 20240218146
- Publication date Jul 4, 2024
- Teknologian Tutkimuskeskus VTT Oy
- Kari KOIVURANTA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SEMAGLUTIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICA...
- Publication number 20240199717
- Publication date Jun 20, 2024
- NINGBO KUNPENG BIOTECH CO., LTD.
- Ge YU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CARTILAGE EXTRACT WITH EFFECT OF IMPROVING IMMUNE RESPONSE, PREPARA...
- Publication number 20240173357
- Publication date May 30, 2024
- Haiyan WANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IMMUNOGENIC PROTEIN HYDROLYSATE WITH REDUCED ALLERGENICITY
- Publication number 20240150418
- Publication date May 9, 2024
- Arla Foods amba
- Hans Peter Sørensen
- C07 - ORGANIC CHEMISTRY
Information Patent Application
HYBRID AMEBOCYTE LYSATE AND USES THEREOF
- Publication number 20240125789
- Publication date Apr 18, 2024
- Charles River Laboratories, Inc.
- Norman R. Wainwright
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
FUSION PROTEIN CONTAINING TISSUE PLASMINOGEN ACTIVATOR OR ITS VARIA...
- Publication number 20240084280
- Publication date Mar 14, 2024
- National Cheng Kung University
- Woei-Jer CHUANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods for Treating Conditions Associated with MASP-2 Dependent Co...
- Publication number 20230391889
- Publication date Dec 7, 2023
- University of Leicester
- Hans-Wilhelm Schwaeble
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
NOVEL RECOMBINANT FACTOR C AND METHOD FOR PRODUCING THE SAME, AND M...
- Publication number 20230357742
- Publication date Nov 9, 2023
- Seikagaku Corporation
- Hikaru MIZUMURA
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL PROINSULIN GLARGINE AND METHOD FOR PREPARING INSULIN GLARGINE...
- Publication number 20230287077
- Publication date Sep 14, 2023
- Amphastar Nanjing Pharmaceuticals, Inc.
- Chuangen TANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
HYBRID AMEBOCYTE LYSATE AND USES THEREOF
- Publication number 20230258647
- Publication date Aug 17, 2023
- Charles River Laboratories, Inc.
- Norman R. Wainwright
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COLD PROTEASE TREATMENT METHOD FOR PREPARING BIOLOGICAL SAMPLES
- Publication number 20230220368
- Publication date Jul 13, 2023
- 10X Genomics, Inc.
- Albert Kim
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF
- Publication number 20220213200
- Publication date Jul 7, 2022
- Biogen MA Inc.
- Joe Salas
- C07 - ORGANIC CHEMISTRY
Information Patent Application
PURIFIED FISH PROTEASES WITH HIGH SPECIFIC ACTIVITIES AND ITS PROCE...
- Publication number 20220204922
- Publication date Jun 30, 2022
- BIOSEUTICA B.V.
- Alex Nobar Yousif
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
NOVEL RECOMBINANT FACTOR C AND METHOD FOR PRODUCING THE SAME, AND M...
- Publication number 20220145280
- Publication date May 12, 2022
- Seikagaku Corporation
- Hikaru MIZUMURA
- G01 - MEASURING TESTING
Information Patent Application
METHODS FOR TREATING ARTHRITIS USING SPL-108 PEPTIDE
- Publication number 20220125893
- Publication date Apr 28, 2022
- Splash Pharmaceuticals, Inc.
- Malcolm Finlayson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHODS FOR STABLE GENOMIC INTEGRATION IN RECOMBINANT MICROORGANISMS
- Publication number 20220025364
- Publication date Jan 27, 2022
- BioPlx, Inc.
- Dan Rouse
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Use of An Enzyme Granule
- Publication number 20220015394
- Publication date Jan 20, 2022
- NOVOZYMES A/S
- Albert E. Cerrera-Padrell
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR ENHANCING SENSITIVITY OF ENDOTOXIN MEASURING AGENT
- Publication number 20210215695
- Publication date Jul 15, 2021
- Seikagaku Corporation
- Norihiko OGURA
- G01 - MEASURING TESTING
Information Patent Application
COMPOSITIONS FOR TREATING CITRUS DISEASE AND PROMOTING YIELD INCREA...
- Publication number 20200255851
- Publication date Aug 13, 2020
- SPOGEN BIOTECH INC.
- Brian Thompson
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Methods for Treating Conditions Associated with MASP-2 Dependent Co...
- Publication number 20200190215
- Publication date Jun 18, 2020
- University of Leicester
- Hans-Wilhelm Schwaeble
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
OPTIMIZATION OF THE EXPRESSION OF SERINE PROTEASES IN HOST CELLS
- Publication number 20200140841
- Publication date May 7, 2020
- B.R.A.I.N. Biotechnology Research and Informaion Network AG
- Alexander PELZER
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF
- Publication number 20200102391
- Publication date Apr 2, 2020
- Biogen MA Inc.
- Joe Salas
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
NOVEL RECOMBINANT FACTOR C AND METHOD FOR PRODUCING THE SAME, AND M...
- Publication number 20190270977
- Publication date Sep 5, 2019
- Seikagaku Corporation
- Hikaru MIZUMURA
- G01 - MEASURING TESTING

Serine endopeptidases (3.4.21)

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Recombinant amebocyte lysate and uses thereof

Recombinant Factor C and method for producing the same, and method...

Recombinant Factor C and method for producing the same, and method...

Method for recombinant production of horseshoe crab Factor C protei...

Optimization of the expression of serine proteases in host cells

Recombinant factor C and method for producing the same, and method...

Methods of isolating and detecting metal ions from proteins

Enhanced fermentation

Protease variants and polynucleotides encoding same

Anti-GPIIB/IIIA antibodies or uses thereof

Protease for wound conditioning and skin care

Method for recombinant production of horseshoe crab factor C protei...

Milling process

Recombinant Factor C and method for producing the same, and method...

Variant AAV and compositions, methods and uses for gene transfer to...

Method for recombinant production of horseshoe crab factor C protei...

Protease screening methods and proteases identified thereby

Expression vector for animal cells including CSP-B 5′-SAR factor an...

Peptides, compositions, and uses thereof

Protease screening methods and proteases identified thereby

Protease for wound conditioning and skin care

Method of enhancing recombinant protein production

Methods for detecting virulent Plasmodium, for evaluating Plasmodiu...

Protease screening methods and proteases identified thereby

Selective enzymatic amidation of C-terminal esters or acids of pept...

Methods of reducing a viral infection and kits therefore

Modified enteropeptidase protein

Methods for detecting virulent Plasmodium, for evaluating Plasmodiu...

Polypeptides recognized by anti-Trichinella antibodies, and uses th...

Protein having prolyl oligopeptidase activity, nucleic acid encodin...

Patents Applicationslast 30 patents

FURIN-CLEAVABLE DELIVERY CONSTRUCTS

REAGENT FOR MEASURING B-GLUCAN, METHOD FOR PRODUCING SAME AND USE T...

ENGINEERED ALPHA-GALACTOSIDASE A (A-GAL A) PEPTIDES AND FUNCTIONAL...

Modified Cell Targeting Tumor ECM and Cellular Therapy thereof

COMPOSITION AND METHOD FOR TREATING HEMOPHILIA B

DETERGENT COMPOSITIONS CONTAINING ENZYMES

METHOD FOR INCREASING THE EXTRACTION RATE OF CHONDROITIN SULFATE PR...

ENZYMES, MICRO-ORGANISMS AND USES THEREOF, AND A METHOD OF DEGRADIN...

SEMAGLUTIDE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICA...

CARTILAGE EXTRACT WITH EFFECT OF IMPROVING IMMUNE RESPONSE, PREPARA...

IMMUNOGENIC PROTEIN HYDROLYSATE WITH REDUCED ALLERGENICITY

HYBRID AMEBOCYTE LYSATE AND USES THEREOF

FUSION PROTEIN CONTAINING TISSUE PLASMINOGEN ACTIVATOR OR ITS VARIA...

Methods for Treating Conditions Associated with MASP-2 Dependent Co...

NOVEL RECOMBINANT FACTOR C AND METHOD FOR PRODUCING THE SAME, AND M...

NOVEL PROINSULIN GLARGINE AND METHOD FOR PREPARING INSULIN GLARGINE...

HYBRID AMEBOCYTE LYSATE AND USES THEREOF

COLD PROTEASE TREATMENT METHOD FOR PREPARING BIOLOGICAL SAMPLES

ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF

PURIFIED FISH PROTEASES WITH HIGH SPECIFIC ACTIVITIES AND ITS PROCE...

NOVEL RECOMBINANT FACTOR C AND METHOD FOR PRODUCING THE SAME, AND M...

METHODS FOR TREATING ARTHRITIS USING SPL-108 PEPTIDE

METHODS FOR STABLE GENOMIC INTEGRATION IN RECOMBINANT MICROORGANISMS

Use of An Enzyme Granule

METHOD FOR ENHANCING SENSITIVITY OF ENDOTOXIN MEASURING AGENT

COMPOSITIONS FOR TREATING CITRUS DISEASE AND PROMOTING YIELD INCREA...

Methods for Treating Conditions Associated with MASP-2 Dependent Co...

OPTIMIZATION OF THE EXPRESSION OF SERINE PROTEASES IN HOST CELLS

ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF

NOVEL RECOMBINANT FACTOR C AND METHOD FOR PRODUCING THE SAME, AND M...