the non-active part being non-polymeric

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A61K48/0033

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AHUMAN NECESSITIES A61Medical science A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases Gene therapy

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A61K48/0033the non-active part being non-polymeric

Industries

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Patents Grantslast 30 patents

Information Patent Grant
Compositions and methods for the delivery of nucleic acids
- Patent number 12,161,659
- Issue date Dec 10, 2024
- Case Western Reserve University
- Zheng-Rong Lu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Compounds and compositions for intracellular delivery of therapeuti...
- Patent number 12,151,995
- Issue date Nov 26, 2024
- ModernaTX, Inc.
- Kerry E. Benenato
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Coronavirus vaccine
- Patent number 12,133,899
- Issue date Nov 5, 2024
- BIONTECH SE
- Ugur Sahin
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Compositions and methods for organ specific delivery of nucleic acids
- Patent number 12,133,924
- Issue date Nov 5, 2024
- The Board of Regents of the University of Texas System
- Qiang Cheng
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Lipid nanoparticle compositions and uses thereof
- Patent number 12,133,923
- Issue date Nov 5, 2024
- ReCode Therapeutics, Inc.
- Mirko Hennig
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods related to megakaryocyte-derived extracell...
- Patent number 12,090,234
- Issue date Sep 17, 2024
- STRM.bio Incorporated
- Jonathan Thon
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Nucleic acids and methods of treatment for cystic fibrosis
- Patent number 12,070,509
- Issue date Aug 27, 2024
- Arcturus Therapeutics, Inc.
- Carlos G. Perez-Garcia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Disulfide bond stabilized polypeptide compositions and methods of use
- Patent number 12,064,485
- Issue date Aug 20, 2024
- Amicus Therapeutics, Inc.
- Hung Do
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
CNS delivery of mRNA and uses thereof
- Patent number 12,016,954
- Issue date Jun 25, 2024
- Translate Bio, Inc.
- Frank DeRosa
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Processes of preparing mRNA-loaded lipid nanoparticles
- Patent number 11,969,480
- Issue date Apr 30, 2024
- Translate Bio, Inc.
- Shrirang Karve
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Lipid nanoparticle formulation
- Patent number 11,969,506
- Issue date Apr 30, 2024
- ModernaTX, Inc.
- Siddharth Patel
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
RNA constructs and uses thereof
- Patent number 11,951,185
- Issue date Apr 9, 2024
- BIONTECH SE
- Ugur Sahin
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Modified viral particles for gene therapy
- Patent number 11,938,196
- Issue date Mar 26, 2024
- BOREA THERAPEUTICS S.R.L.
- Paul Alexander Heppenstall
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Coronavirus vaccine
- Patent number 11,925,694
- Issue date Mar 12, 2024
- BIONTECH SE
- Ugur Sahin
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Lipid formulations for delivery of messenger RNA
- Patent number 11,890,377
- Issue date Feb 6, 2024
- Translate Bio, Inc.
- Michael Heartlein
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Recombinant expression vector and lipid membrane structure having s...
- Patent number 11,814,640
- Issue date Nov 14, 2023
- LUCA Science Inc.
- Hideyoshi Harashima
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Lipid compound as well as lipid vector, nucleic acid lipid nanopart...
- Patent number 11,786,609
- Issue date Oct 17, 2023
- PURECODON (HONG KONG) BIOPHARMA LIMITED
- Ke Huang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
RNA constructs and uses thereof
- Patent number 11,779,659
- Issue date Oct 10, 2023
- BIONTECH SE
- Ugur Sahin
- B82 - NANO-TECHNOLOGY
Information Patent Grant
mRNA targeting molecule comprising N-acetylgalactosamine binding po...
- Patent number 11,759,532
- Issue date Sep 19, 2023
- ShenZhen Rhegen Biotechnology Co., Ltd.
- Yong Hu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
MRNA therapy for pompe disease
- Patent number 11,712,463
- Issue date Aug 1, 2023
- Translate Bio, Inc.
- Frank DeRosa
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Lipid nanoparticle formulations
- Patent number 11,712,481
- Issue date Aug 1, 2023
- Acuitas Therapeutics, Inc.
- Michael J. Hope
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Salt responsive nanogels and nanoparticles
- Patent number 11,707,534
- Issue date Jul 25, 2023
- Howard University
- Preethi Chandran
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Lipid compound as well as lipid carrier, nucleic acid lipid nanopar...
- Patent number 11,690,922
- Issue date Jul 4, 2023
- Purecodon (Hong Kong) Biopharma Ltd.
- Ke Huang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Delivery of target specific nucleases
- Patent number 11,690,921
- Issue date Jul 4, 2023
- Sangamo Therapeutics, Inc.
- Anthony Conway
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Cationic sulfonamide amino lipids and amphiphilic zwitterionic amin...
- Patent number 11,685,710
- Issue date Jun 27, 2023
- The Board of Regents of the University of Texas System
- Daniel J. Siegwart
- B82 - NANO-TECHNOLOGY
Information Patent Grant
Alkenyl substituted 2,5-piperazinediones, compositions, and uses th...
- Patent number 11,679,165
- Issue date Jun 20, 2023
- Massachusetts Institute of Technology
- Daniel Griffith Anderson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for organ specific delivery of nucleic acids
- Patent number 11,648,210
- Issue date May 16, 2023
- The Board of Regents of the University of Texas System
- Qiang Cheng
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Lipids and lipid nanoparticle formulations for delivery of nucleic...
- Patent number 11,648,324
- Issue date May 16, 2023
- Acuitas Therapeutics, Inc.
- Steven M. Ansell
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Functionalized N-acetylgalactosamine nucleosides
- Patent number 11,649,260
- Issue date May 16, 2023
- Hongene Biotech Corporation
- Xiaoyang Guan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Compositions and methods for organ specific delivery of nucleic acids
- Patent number 11,648,209
- Issue date May 16, 2023
- The Board of Regents of the University of Texas System
- Qiang Cheng
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
- Publication number 20240417370
- Publication date Dec 19, 2024
- Acuitas Therapeutics, Inc.
- Jason Samuel Tan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS
- Publication number 20240409597
- Publication date Dec 12, 2024
- ModernaTX, Inc.
- Antonin DE FOUGEROLLES
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY
- Publication number 20240408200
- Publication date Dec 12, 2024
- WILSON WOLF MANUFACTURING
- Juan F. Vera
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CNS DELIVERY OF MRNA AND USES THEREOF
- Publication number 20240408013
- Publication date Dec 12, 2024
- Translate Bio, Inc.
- Frank DeRosa
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
LIPID NANOPARTICLE USED FOR DELIVERING NUCLEIC ACID TO BRAIN TISSUE
- Publication number 20240408230
- Publication date Dec 12, 2024
- NOF Corporation
- Kota TANGE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
GENE DELIVERY COMPOSITION COMPRISING NITROGEN-DOPED GRAPHENE QUANTU...
- Publication number 20240408231
- Publication date Dec 12, 2024
- GRAPHENE SQUARE CHEMICAL INC.
- Byung Hee HONG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
LIPID NANOPARTICLE FORMULATIONS AND COMPOSITIONS
- Publication number 20240398982
- Publication date Dec 5, 2024
- CAPSTAN THERAPEUTICS, INC.
- Priya Prakash Karmali
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ADENO-ASSOCIATED VECTORS AND VIRIONS TO TREAT GALACTOSEMIA AND METH...
- Publication number 20240390516
- Publication date Nov 28, 2024
- Jaguar Gene Therapy, LLC
- Michael Hughes
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
AAV-MEDIATED EXPRESSION OF LONG-ACTING ANTI-CCR5 BINDING AGENTS FOR...
- Publication number 20240392014
- Publication date Nov 28, 2024
- Oregon Health & Science University
- Jonah Sacha
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
IONIZABLE LIPIDS
- Publication number 20240390284
- Publication date Nov 28, 2024
- Bristol-Myers Squibb Company
- Kendall Condon
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE-DRUG CONJUGATE
- Publication number 20240390508
- Publication date Nov 28, 2024
- Takeda Pharmaceutical Company Limited
- Takatoshi YOGO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
RNA CONSTRUCTS AND USES THEREOF
- Publication number 20240390524
- Publication date Nov 28, 2024
- BIONTECH SE
- Ugur Sahin
- B82 - NANO-TECHNOLOGY
Information Patent Application
COMPOSITIONS FOR AND METHODS OF TREATING AND/OR PREVENTING GLUTARIC...
- Publication number 20240384274
- Publication date Nov 21, 2024
- DUKE UNIVERSITY
- Collin G. Johnson
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PROTEOLIPID VESICLES FORMULATED WITH FUSION ASSOCIATED SMALL TRANSM...
- Publication number 20240374520
- Publication date Nov 14, 2024
- ENTOS PHARMACEUTICALS INC.
- John David Lewis
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
EFFECTOR PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF FOR MANUFA...
- Publication number 20240366678
- Publication date Nov 7, 2024
- MAMMOTH BIOSCIENCES, INC.
- Mark Alan DEWITT
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
PROCESSES OF PREPARING MRNA-LOADED LIPID NANOPARTICLES
- Publication number 20240366798
- Publication date Nov 7, 2024
- Translate Bio, Inc.
- Shrirang Karve
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
COMPOSITIONS AND METHODS FOR IMPROVED TREATMENT OF X-LINKED MYOTUBU...
- Publication number 20240366785
- Publication date Nov 7, 2024
- Audentes Therapeutics, Inc.
- Weston MILLER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
EPIGENETIC GENE REGULATION TO TREAT NEUROLOGICAL DISEASES AND PAIN
- Publication number 20240366795
- Publication date Nov 7, 2024
- Navega Therapeutics, Inc.
- Fernando ALEMAN GUILLEN
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
COMPOSITIONS AND METHODS FOR IMPROVED TREATMENT OF DISORDERS AFFECT...
- Publication number 20240358794
- Publication date Oct 31, 2024
- King's College London
- Christopher SHAW
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Cationic Lipid Compound and Composition for Delivery of Nucleic Aci...
- Publication number 20240360072
- Publication date Oct 31, 2024
- Shenzhen Rhegen Biotechnology Co., Ltd.
- Yong HU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TREATMENT OF MUSCULAR DYSTROPHY
- Publication number 20240350674
- Publication date Oct 24, 2024
- Solid Biosciences Inc.
- Kristy Jean Brown
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CHAPERONES AS AN AUTOPHAGY RECEPTORS FOR CLEARANCES OF PROTEIN AGGR...
- Publication number 20240350586
- Publication date Oct 24, 2024
- TSINGHUA UNIVERSITY
- Liang GE
- G01 - MEASURING TESTING
Information Patent Application
Compositions and Methods for Treatment and Prevention of Misfolded...
- Publication number 20240342241
- Publication date Oct 17, 2024
- The Trustees of the University of Pennsylvania
- Xiaolu Yang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Liver Specific Delivery of Messenger RNA
- Publication number 20240342307
- Publication date Oct 17, 2024
- Translate Bio, Inc.
- Braydon Charles Guild
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
Methods and Compositions for Treating Conditions Involving the Eye
- Publication number 20240342308
- Publication date Oct 17, 2024
- Krystal Biotech, Inc.
- Suma Krishnan
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
A SHORTENED P63-PROTEIN DOMAIN TO ENHANCE HUMAN CARDIAC REPROGRAMMING
- Publication number 20240342312
- Publication date Oct 17, 2024
- Baylor College of Medicine
- Todd Rosengart
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
AMPHIPHILIC PEPTIDES FOR NUCLEIC ACID AND PROTEIN DELIVERY
- Publication number 20240336655
- Publication date Oct 10, 2024
- AJK BIOPHARMACEUTICAL, LLC
- Keykavous PARANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
IONIZABLE LIPID BASED ON ENDOGENOUS DICARBOXYLIC ACID AS WELL AS PR...
- Publication number 20240336558
- Publication date Oct 10, 2024
- SHANDONG UNIVERSITY
- Xinyi JIANG
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
IONIZABLE AMINE LIPIDS AND LIPID NANOPARTICLES
- Publication number 20240335385
- Publication date Oct 10, 2024
- Beam Therapeutics Inc.
- Cory Dane Sago
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CYCLOHEXANE LIPIDOIDS FOR NUCLEIC ACID TRANSFECTION AND USE THEREOF
- Publication number 20240335559
- Publication date Oct 10, 2024
- USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V.V.I.
- Petr CIGLER
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

the non-active part being non-polymeric

Industry

Parent Industries

Current Industry

Patents Grantslast 30 patents

Compositions and methods for the delivery of nucleic acids

Compounds and compositions for intracellular delivery of therapeuti...

Coronavirus vaccine

Compositions and methods for organ specific delivery of nucleic acids

Lipid nanoparticle compositions and uses thereof

Compositions and methods related to megakaryocyte-derived extracell...

Nucleic acids and methods of treatment for cystic fibrosis

Disulfide bond stabilized polypeptide compositions and methods of use

CNS delivery of mRNA and uses thereof

Processes of preparing mRNA-loaded lipid nanoparticles

Lipid nanoparticle formulation

RNA constructs and uses thereof

Modified viral particles for gene therapy

Coronavirus vaccine

Lipid formulations for delivery of messenger RNA

Recombinant expression vector and lipid membrane structure having s...

Lipid compound as well as lipid vector, nucleic acid lipid nanopart...

RNA constructs and uses thereof

mRNA targeting molecule comprising N-acetylgalactosamine binding po...

MRNA therapy for pompe disease

Lipid nanoparticle formulations

Salt responsive nanogels and nanoparticles

Lipid compound as well as lipid carrier, nucleic acid lipid nanopar...

Delivery of target specific nucleases

Cationic sulfonamide amino lipids and amphiphilic zwitterionic amin...

Alkenyl substituted 2,5-piperazinediones, compositions, and uses th...

Compositions and methods for organ specific delivery of nucleic acids

Lipids and lipid nanoparticle formulations for delivery of nucleic...

Functionalized N-acetylgalactosamine nucleosides

Compositions and methods for organ specific delivery of nucleic acids

Patents Applicationslast 30 patents

LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS

MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS

METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY

CNS DELIVERY OF MRNA AND USES THEREOF

LIPID NANOPARTICLE USED FOR DELIVERING NUCLEIC ACID TO BRAIN TISSUE

GENE DELIVERY COMPOSITION COMPRISING NITROGEN-DOPED GRAPHENE QUANTU...

LIPID NANOPARTICLE FORMULATIONS AND COMPOSITIONS

ADENO-ASSOCIATED VECTORS AND VIRIONS TO TREAT GALACTOSEMIA AND METH...

AAV-MEDIATED EXPRESSION OF LONG-ACTING ANTI-CCR5 BINDING AGENTS FOR...

IONIZABLE LIPIDS

HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE-DRUG CONJUGATE

RNA CONSTRUCTS AND USES THEREOF

COMPOSITIONS FOR AND METHODS OF TREATING AND/OR PREVENTING GLUTARIC...

PROTEOLIPID VESICLES FORMULATED WITH FUSION ASSOCIATED SMALL TRANSM...

EFFECTOR PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF FOR MANUFA...

PROCESSES OF PREPARING MRNA-LOADED LIPID NANOPARTICLES

COMPOSITIONS AND METHODS FOR IMPROVED TREATMENT OF X-LINKED MYOTUBU...

EPIGENETIC GENE REGULATION TO TREAT NEUROLOGICAL DISEASES AND PAIN

COMPOSITIONS AND METHODS FOR IMPROVED TREATMENT OF DISORDERS AFFECT...

Cationic Lipid Compound and Composition for Delivery of Nucleic Aci...

TREATMENT OF MUSCULAR DYSTROPHY

CHAPERONES AS AN AUTOPHAGY RECEPTORS FOR CLEARANCES OF PROTEIN AGGR...

Compositions and Methods for Treatment and Prevention of Misfolded...

Liver Specific Delivery of Messenger RNA

Methods and Compositions for Treating Conditions Involving the Eye

A SHORTENED P63-PROTEIN DOMAIN TO ENHANCE HUMAN CARDIAC REPROGRAMMING

AMPHIPHILIC PEPTIDES FOR NUCLEIC ACID AND PROTEIN DELIVERY

IONIZABLE LIPID BASED ON ENDOGENOUS DICARBOXYLIC ACID AS WELL AS PR...

IONIZABLE AMINE LIPIDS AND LIPID NANOPARTICLES

CYCLOHEXANE LIPIDOIDS FOR NUCLEIC ACID TRANSFECTION AND USE THEREOF