Claims
- 1. An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence at least 95% identical to a sequence selected from the group consisting of:
(a) a polynucleotide fragment of SEQ ID NO:X or a polynucleotide fragment of the cDNA sequence included in ATCC Deposit No:Z, which is hybridizable to SEQ ID NO:X; (b) a polynucleotide encoding a polypeptide fragment of SEQ ID NO:Y or a polypeptide fragment encoded by the cDNA sequence included in ATCC Deposit No:Z, which is hybridizable to SEQ ID NO:X; (c) a polynucleotide encoding a polypeptide domain of SEQ ID NO:Y or a polypeptide domain encoded by the cDNA sequence included in ATCC Deposit No:Z, which is hybridizable to SEQ ID NO:X; (d) a polynucleotide encoding a polypeptide epitope of SEQ ID NO:Y or a polypeptide epitope encoded by the cDNA sequence included in ATCC Deposit No:Z, which is hybr idizable to SEQ ID NO:X; (e) a polynucleotide encoding a polypeptide of SEQ ID NO: Y or the cDNA sequence included in ATCC Deposit No:Z, which is hybridizable to SEQ ID NO:X, having biological activity; (f) a polynucleotide which is a variant of SEQ ID NO:X; (g) a polynucleotide which is an allelic variant of SEQ ID NO:X; (h) a polynucleotide which encodes a species homologue of the SEQ ID NO:Y; (i) a polynucleotide capable of hybridizing under stringent conditions to any one of the polynucleotides specified in (a)-(h), wherein said polynucleotide does not hybridize under stringent conditions to a nucleic acid molecule having a nucleotide sequence of only A residues or of only T residues.
- 2. The isolated nucleic acid molecule of claim 1, wherein the polynucleotide fragment comprises a nucleotide sequence encoding a secreted protein.
- 3. The isolated nucleic acid molecule of claim 1, wherein the polynucleotide fragment comprises a nucleotide sequence encoding the sequence identified as SEQ ID NO:Y or the polypeptide encoded by the cDNA sequence included in ATCC Deposit No:Z, which is hybridizable to SEQ ID NO:X.
- 4. The isolated nucleic acid molecule of claim 1, wherein the polynucleotide fragment comprises the entire nucleotide sequence of SEQ ID NO:X or the cDNA sequence included in ATCC Deposit No:Z, which is hybridizable to SEQ ID NO:X.
- 5. The isolated nucleic acid molecule of claim 2, wherein the nucleotide sequence comprises sequential nucleotide deletions from either the C-terminus or the N-terminus.
- 6. The isolated nucleic acid molecule of claim 3, wherein the nucleotide sequence comprises sequential nucleotide deletions from either the C-terminus or the N-terminus.
- 7. A recombinant vector comprising the isolated nucleic acid molecule of claim 1.
- 8. A method of making a recombinant host cell comprising the isolated nucleic acid molecule of claim 1.
- 9. A recombinant host cell produced by the method of claim 8.
- 10. The recombinant host cell of claim 9 comprising vector sequences.
- 11. An isolated polypeptide comprising an amino acid sequence at least 95% identical to a sequence selected from the group consisting of:
(a) a polypeptide fragment of SEQ ID NO:Y or the encoded sequence included in ATCC Deposit No:Z; (b) a polypeptide fragment of SEQ ID NO:Y or the encoded sequence included in ATCC Deposit No:Z, having biological activity; (c) a polypeptide domain of SEQ ID NO:Y or the encoded sequence included in ATCC Deposit No:Z; (d) a polypeptide epitope of SEQ ID NO:Y or the encoded sequence included in ATCC Deposit No:Z; (e) a secreted form of SEQ ID NO:Y or the encoded sequence included in ATCC Deposit No:Z; (f) a full length protein of SEQ ID NO:Y or the encoded sequence included in ATCC Deposit No:Z; (g) a variant of SEQ ID NO:Y; (h) an allelic variant of SEQ ID NO:Y; or (i) a species homologue of the SEQ ID NO:Y.
- 12. The isolated polypeptide of claim 11, wherein the secreted form or the full length protein comprises sequential amino acid deletions from either the C-terminus or the N-terminus.
- 13. An isolated antibody that binds specifically to the isolated polypeptide of claim 11.
- 14. A recombinant host cell that expresses the isolated polypeptide of claim 11.
- 15. A method of making an isolated polypeptide comprising:
(a) culturing the recombinant host cell of claim 14 under conditions such that said polypeptide is expressed; and (b) recovering said polypeptide.
- 16. The polypeptide produced by claim 15.
- 17. A method for preventing, treating, or ameliorating a medical condition, comprising administering to a mammalian subject a therapeutically effective amount of the polypeptide of claim 11.
- 18. A method for preventing, treating, or ameliorating a medical condition, comprising administering to a mammalian subject a therapeutically effective amount of the polynucleotide of claim 1.
- 19. A method of diagnosing a pathological condition or a susceptibility to a pathological condition in a subject comprising:
(a) determining the presence or absence of a mutation in the polynucleotide of claim 1; and (b) diagnosing a pathological condition or a susceptibility to a pathological condition based on the presence or absence of said mutation.
- 20. A method of diagnosing a pathological condition or a susceptibility to a pathological condition in a subject comprising:
(a) determining the presence or amount of expression of the polypeptide of claim 11 in a biological sample; and (b) diagnosing a pathological condition or a susceptibility to a pathological condition based on the presence or amount of expression of the polypeptide.
- 21. A method for identifying a binding partner to the polypeptide of claim 11 comprising:
(a) contacting the polypeptide of claim 11 with a binding partner; and (b) determining whether the binding partner effects an activity of the polypeptide.
- 22. The gene corresponding to the cDNA sequence of SEQ ID NO:X.
- 23. A method of identifying an activity in a biological assay., wherein the method comprises:
(a) expressing SEQ ID NO:X in a cell; (b) isolating the supernatant; (c) detecting an activity in a biological assay; and (d) identifying the protein in the supernatant having the activity.
- 24. The product produced by the method of claim 20.
Parent Case Info
[0001] This application claims benefit under 35 U.S.C. § 119(e) of U.S. Provisional Patent Application No. 60/239,899, filed Oct. 13, 2000, which is hereby incorporated by reference; this application is also a continuation-in-part of, and claims benefit under 35 U.S.C. § 120 of copending U.S. patent application Ser. No. 09/227,357, filed Jan. 8, 1999, which is hereby incorporated by reference, and and which is a continuation-in-part, and claims benefit under 35 U.S.C. § 120 of copending International patent application Serial No: PCT/US98/13684, filed Jul. 7, 1998 and published in English, which is hereby incorporated by reference, which claims benefit under 35 U.S.C. § 119(e) based on U.S. Provisional Applications, all of which are hereby incorporated by reference:
1Filing DateAppln No.1.08-Jul-199760/051,9262.08-Jul-199760/052,7933.08-Jul-199760/051,9254.08-Jul-199760/051,9295.08-Jul-199760/052,8036.08-Jul-199760/052,7327.08-Jul-199760/051,9318.08-Jul-199760/051,9329.08-Jul-199760/051,91610.08-Jul-199760/051,93011.08-Jul-199760/051,91812.08-Jul-199760/051,92013.08-Jul-199760/052,73314.08-Jul-199760/052,79515.08-Jul-199760/051,91916.08-Jul-199760/051,92817.18-Aug-199760/055,72218.18-Aug-199760/055,72319.18-Aug-199760/055,94820.18-Aug-199760/055,94921.18-Aug-199760/055,95322.18-Aug-199760/055,95023.18-Aug-199760/055,94724.18-Aug-199760/055,96425.18-Aug-199760/056,36026.18-Aug-199760/055,68427.18-Aug-199760/055,98428.18-Aug-199760/055,95429.12-Sep-199760/058,78530.12-Sep-199760/058,66431.12-Sep-199760/058,66032.12-Sep-199760/058,661
Provisional Applications (33)
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Number |
Date |
Country |
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60239899 |
Oct 2000 |
US |
|
60051926 |
Jul 1997 |
US |
|
60052793 |
Jul 1997 |
US |
|
60051925 |
Jul 1997 |
US |
|
60051929 |
Jul 1997 |
US |
|
60052803 |
Jul 1997 |
US |
|
60052732 |
Jul 1997 |
US |
|
60051931 |
Jul 1997 |
US |
|
60051932 |
Jul 1997 |
US |
|
60051916 |
Jul 1997 |
US |
|
60051930 |
Jul 1997 |
US |
|
60051918 |
Jul 1997 |
US |
|
60051920 |
Jul 1997 |
US |
|
60052733 |
Jul 1997 |
US |
|
60052795 |
Jul 1997 |
US |
|
60051919 |
Jul 1997 |
US |
|
60051928 |
Jul 1997 |
US |
|
60055722 |
Aug 1997 |
US |
|
60055723 |
Aug 1997 |
US |
|
60055948 |
Aug 1997 |
US |
|
60055949 |
Aug 1997 |
US |
|
60055953 |
Aug 1997 |
US |
|
60055950 |
Aug 1997 |
US |
|
60055947 |
Aug 1997 |
US |
|
60055964 |
Aug 1997 |
US |
|
60056360 |
Aug 1997 |
US |
|
60055684 |
Aug 1997 |
US |
|
60055984 |
Aug 1997 |
US |
|
60055954 |
Aug 1997 |
US |
|
60058785 |
Sep 1997 |
US |
|
60058664 |
Sep 1997 |
US |
|
60058660 |
Sep 1997 |
US |
|
60058661 |
Sep 1997 |
US |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
09227357 |
Jan 1999 |
US |
Child |
09973278 |
Oct 2001 |
US |
Parent |
PCT/US98/13684 |
Jul 1998 |
US |
Child |
09227357 |
Jan 1999 |
US |