Claims
- 1. A process for the preparation of a compound having structure I ##STR18## wherein A is hydrogen or C.sub.1 -C.sub.4 alkyl;
- W is CN, NO.sub.2 or CO.sub.2 R.sub.6
- L is hydrogen or halogen and
- M and R are each independently hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, CN, NO.sub.2, halogen, CF.sub.3, R.sub.1 CF.sub.2 Z, R.sub.2 CO or NR.sub.3 R.sub.4 and when M and R are on adjacent positions they may be taken together with the carbon atoms to which they are attached to form a ring in which MR represents the structure
- --OCH.sub.2 O--, --OCF.sub.2 O-- or --CH.dbd.CH--CH.dbd.CH--;
- z is s(o).sub.n or o;
- R.sub.1 is hydrogen, F, CHF.sub.2, CHFCl or CF.sub.3 ;
- R.sub.2 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or NR.sub.3 R.sub.4 ;
- R.sub.3 is hydrogen or C.sub.1 -C.sub.4 alkyl;
- R.sub.4 is hydrogen, C.sub.1 -C.sub.4 alkyl or R.sub.5 CO;
- R.sub.5 is hydrogen or C.sub.1 -C.sub.4 alkyl;
- R.sub.6 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl or phenyl;
- n is an integer of 0, 1 or 2
- which comprises reacting a compound having structure II ##STR19## wherein A, L, M and R are as defined above with about 1.0 molar equivalent of an olefin having the structure
- H.sub.2 C.dbd.CHW,
- wherein W is as defined above and optionally a catalytic amount of an organic base in the presence of an acid anhydride and a solvent.
- 2. The process according to claim 1 wherein the organic base is tri(C.sub.1 -C.sub.4 alkyl)amine and the solvent is acetonitrile.
- 3. The process according to claim 1 wherein W is CN, A is methyl, L and R are hydrogen and M is halogen.
- 4. The process according to claim 1 wherein W is CN, A is hydrogen, L and R are hydrogen and M is halogen.
Parent Case Info
This is a divisional of copending application(s) Ser. No. 07/865,149 filed on Apr. 8, 1992, now U.S. Pat. No. 5,288,901 and Ser. No. 07/634,287, filed on Dec. 26, 1990, now U.S. Pat. No. 5,118,816.
US Referenced Citations (8)
Foreign Referenced Citations (1)
Number |
Date |
Country |
1470386 |
Mar 1969 |
DEX |
Non-Patent Literature Citations (1)
Entry |
Martin et al., "2-Phenylaspartic Acid Derivatives from Beta-Lactams," J. Org. Chem, 35(11), pp. 3814-3818, 1970. |
Divisions (2)
|
Number |
Date |
Country |
Parent |
865149 |
Apr 1992 |
|
Parent |
634287 |
Dec 1990 |
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