Claims
- 1. A 7-acyl-3-substituted carbamoyloxy cephem compound represented by the following formula (1): ##STR174## wherein A means a --CH.dbd. or --N.dbd. group; R.sup.1 denotes a hydroxyl group, a lower alkoxyl group, a fluorine-substituted lower alkoxyl group or a hydroxyl group protected by a protecting group; R.sup.2 and R.sup.3 are the same or different and individually represent a lower alkyl group, a hydroxyl-substituted lower alkyl group, a carbamoyl-substituted lower alkyl group or a cyano-substituted lower alkyl group, R.sup.2 is a hydrogen atom and R.sup.3 is a lower alkoxyl group or a lower alkyl group which may optionally be substituted by one or more halogen atoms or the group represented by the formula ##STR175## means a 4-6 membered heterocyclic group, which contains one nitrogen atom, or a morpholino group, said heterocyclic group or morpholino group being optionally substituted by one or more lower alkyl, hydroxyl and/or hydroxyl-substituted lower alkyl groups; and R.sup.4 denotes a carboxyl group or a carboxyl group protected by a protecting group; or a pharmaceutically acceptable salt thereof.
- 2. The compound of claim 1, wherein A means a --CH.dbd. group.
- 3. The compound of claim 1, wherein A means a --N.dbd. group.
- 4. The compound of claim 1, wherein R.sup.1 is a hydroxyl group.
- 5. The compound of claim 1, wherein the formula ##STR176## means a group ##STR177## --NHCH.sub.3 or --N(CH.sub.3).sub.2.
- 6. The compound of claim 1, wherein R.sup.2 and R.sup.3 are both methyl groups.
- 7. The compound of claim 1, wherein R.sup.1 is a hydroxyl or protected hydroxyl group, and R.sup.2 and R.sup.3 are both methyl groups.
- 8. The compound of claim 1 or 7, wherein R.sup.4 represents a carboxyl group or a carboxyl group protected by at least one group selected from the class consisting of 1-(isopropyloxycarbonyloxy)ethyl group, 1-(ethoxycabonyloxy)ethyl group, 1-(cyclohexyloxycarbonyloxy)ethyl group, pivaloyloxymethyl group and isopropyloxycarbonyloxymethyl group.
- 9. The compound of claim 1 or 7, wherein R.sup.4 is a carboxyl group or a carboxyl group protected by 1-(isopropyloxycarbonyloxy)ethyl group.
Priority Claims (4)
Number |
Date |
Country |
Kind |
2-302783 |
Nov 1990 |
JPX |
|
3-40747 |
Feb 1991 |
JPX |
|
3-67709 |
Mar 1991 |
JPX |
|
3-169512 |
Apr 1991 |
JPX |
|
Parent Case Info
This is a continuation application of Ser. No. 08/209,484, filed Mar. 14, 1994; which is a continuation of now abandoned Ser. No. 07/789,669, filed Nov. 8, 1991.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4264595 |
Numata et al. |
Apr 1981 |
|
4278671 |
Ochiai et al. |
Jul 1981 |
|
4912212 |
Ochiai et al. |
Mar 1990 |
|
Continuations (2)
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Number |
Date |
Country |
Parent |
209484 |
Mar 1994 |
|
Parent |
789669 |
Nov 1991 |
|