Claims
- 1. An adhesive for sealing a wound, the adhesive comprising a cyanoacrylate, a substance, and a defect forming agent, wherein the defect forming agent is capable of being removed from a cured cyanoacrylate matrix by solvation in an aqueous solution whereby a plurality of defects in the matrix are formed permitting release of the substance from the matrix at a controlled rate.
- 2. The adhesive of claim 1, wherein the cyanoacrylate comprises butyl acrylate.
- 3. The adhesive of claim 1, wherein the cyanoacrylate comprises octyl acrylate.
- 4. The adhesive of claim 1, wherein the defect forming agent comprises a hydrophilic polymer.
- 5. The adhesive of claim 4, wherein the hydrophilic polymer comprises polyethylene glycol.
- 6. The adhesive of claim 5, wherein the polyethylene glycol has an average molecular weight of about 600.
- 7. The adhesive of claim 1, wherein the substance comprises a therapeutic agent.
- 8. The adhesive of claim 7, wherein the therapeutic agent is selected from the group consisting of anti-inflammatory agents, anti-infective agents, immunosuppressive agents, and anesthetic agents.
- 9. The adhesive of claim 7, wherein the therapeutic agent comprises an antibiotic.
- 10. The adhesive of claim 1, further comprising a water-soluble acidic antidegradation agent.
- 11. The adhesive of claim 10, wherein the water-soluble acidic antidegradation agent comprises Vitamin C.
- 12. A method of sealing a wound, the method comprising the steps of:
approximating the wound; applying an adhesive comprising a cyanoacrylate, a substance, and a water soluble defect forming agent to a tissue surface surrounding the wound; and curing the adhesive, whereby the wound is sealed.
- 13. The method of claim 12, further comprising the steps of:
removing the defect forming agent from the cured adhesive by solvating the defect forming agent in a body fluid; and delivering the substance to the tissue surface beneath the cured adhesive via defects formed by removal of the defect forming agent.
- 14. The method of claim 12, wherein the cyanoacrylate comprises butyl acrylate.
- 15. The method of claim 12, wherein the cyanoacrylate comprises octyl acrylate.
- 16. The method of claim 12, wherein the defect forming agent comprises a hydrophilic polymer.
- 17. The method of claim 16, wherein the hydrophilic polymer comprises polyethylene glycol.
- 18. The method of claim 17, wherein the polyethylene glycol has an average molecular weight of about 600.
- 19. The method of claim 12, wherein the substance comprises a therapeutic agent.
- 20. The method of claim 19, wherein the therapeutic agent is selected from the group consisting of anti-inflammatory agents, anti-infective agents, immunosuppressive agents, and anesthetic agents.
- 21. The method of claim 19, wherein the therapeutic agent comprises an antibiotic.
- 22. The method of claim 12, wherein the wound comprises a skin laceration.
- 23. The method of claim 12, wherein the adhesive further comprises a water-soluble acidic antidegradation agent.
- 24. The method of claim 23, wherein the water-soluble acidic antidegradation agent comprises Vitamin C.
Parent Case Info
[0001] This application claims priority under 35 U.S.C. §119(e) to the following U.S. provisional applications: Serial No. 60/306,572, filed Jul. 19, 2001, Serial No. 60/308,993, filed Jul. 31, 2001, Serial No. 60/337,662, filed Nov. 7, 2001, and Serial No. ______, filed Dec. 17, 2001, the disclosures of which are hereby incorporated by reference in their entireties.
Provisional Applications (4)
|
Number |
Date |
Country |
|
60306572 |
Jul 2001 |
US |
|
60308993 |
Jul 2001 |
US |
|
60337662 |
Nov 2001 |
US |
|
60341598 |
Dec 2001 |
US |