Claims
- 1. A method for removing serum amyloid protein form body fluid comprising the sequential steps of:
- a) combining body fluid containing serum amyloid protein with an adsorbent for the serum amyloid protein comprising a water-insoluble carrier and either
- (i) a group bonded to said carrier of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is a hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying the value of log P from 0 to 3.2, in which P is a distribution coefficient in a water-octanol system of a compound of the formula R.sup.2 H, or
- (ii) a compound immobilized onto said carrier selected from the group consisting of aniline and an aniline derivative;
- b) passing the body fluid containing said adsorbent through a filter through which the adsorbent cannot pass; and
- c) recovering substantially serum amyloid protein free body fluid.
- 2. A method for removing serum amyloid protein from body fluid comprising the sequential steps of:
- a) combining body fluid containing serum amyloid protein with a adsorbent for the serum amyloid protein comprising a water-insoluble carrier and a compound immobilized onto said carrier selected from the group consisting of aniline and an aniline derivative;
- b) passing the body fluid containing said adsorbent through a filter through which the adsorbent cannot pass; and
- c) recovering substantially serum amyloid protein from body fluid.
- 3. The method of claim 2, wherein said serum amyloid protein is serum amyloid A protein.
- 4. The method of claim 2, wherein said serum amyloid protein is serum amyloid P protein.
- 5. The method of claim 2, wherein said group is bonded to at least part of the surface of said water-insoluble carrier.
- 6. A method for removing serum amyloid protein from body fluid comprising the sequential steps of:
- a) combining body fluid containing serum amyloid protein with an adsorbent for the serum amyloid protein comprising a water-insoluble carrier and a group, bonded to said carrier, of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is a hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying the value of log P from 0-3.2 in which P is a distribution coefficient in a water-octanol system of a compound of the formula R.sup.2 H;
- b) passing the body fluid containing said adsorbent through a filter through which the adsorbent cannot pass; and
- c) recovering substantially serum amyloid protein free body fluid.
- 7. The method of claim 6, wherein said serum amyloid is serum amyloid A protein.
- 8. The method of claim 6, wherein said serum amyloid protein is serum amyloid P protein.
Priority Claims (3)
Number |
Date |
Country |
Kind |
62-294810 |
Nov 1987 |
JPX |
|
62-294811 |
Nov 1987 |
JPX |
|
62-330617 |
Dec 1987 |
JPX |
|
Parent Case Info
This is a continuation of application Ser. No. 07/272,960 filed Nov. 18, 1988 now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4100149 |
Meiller |
Jul 1978 |
|
4782014 |
Serban |
Nov 1988 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0206302 |
Dec 1986 |
EPX |
Non-Patent Literature Citations (5)
Entry |
Pepys et al, 105 Clin. Chem. ACTA 83-82 (1980) (Abstract). |
Ku et al, 158 J. Exp. Med. 767-780 (1983) (Abstract). |
Kato et al, 31 Jikeikai Med. J. 165-167 (Abstract). |
Parker et al, 9 Biochem. 1074-1082 (1970). |
Ortega et al, Chemical Abstracts 102:44057c (1985). |
Continuations (1)
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Number |
Date |
Country |
Parent |
272960 |
Nov 1988 |
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