Patent Grant
12109427
The present invention generally relates to methods using the influence of magnetic and induced electric field on biological structure. The magnetic field is time-varying and high powered therefore the method is based on a value of magnetic flux density sufficient to induce at least partial muscle contraction.
Aesthetic medicine includes all treatments resulting in enhancing a visual appearance and satisfaction of the patient. Patients want to minimize all imperfections including body shape and effects of natural aging. Indeed, patients request quick, non-invasive procedures providing satisfactory results with minimal risks.
The most common methods used for non-invasive aesthetic applications are based on application of mechanical waves, e.g. ultrasound or shock wave therapy; or electromagnetic waves, e.g. radiofrequency treatment or light treatment, such as intense pulsed light or laser treatment. The effect of mechanical waves on tissue is based especially on cavitation, vibration and/or heat inducing effects. The effect of applications using electromagnetic waves is based especially on heat production in the biological structure.
Skin tissue is composed of three basic elements: epidermis, dermis and hypodermis or so called subcutis. The outer and also the thinnest layer of skin is the epidermis. The dermis consists of collagen, elastic tissue and reticular fibers. The hypodermis is the lowest layer of the skin and contains hair follicle roots, lymphatic vessels, collagen tissue, nerves and also fat forming a subcutaneous white adipose tissue (SWAT). The adipose cells create lobules which are bounded by connective tissue, fibrous septa (retinaculum cutis).
Another part of adipose tissue, so called visceral fat, is located in the peritoneal cavity and forms visceral white adipose tissue (VWAT) located between parietal peritoneum and visceral peritoneum, closely below muscle fibers adjoining the hypodermis layer.
Existing devices have low efficiency and they waste energy, which limits their use. Eddy currents induced within the coil create engineering challenges. Existing devices contain coils which are made of metallic strips, electric wires or hollow conductors. Since the therapy requires large currents, significant losses are caused by induced eddy currents within the coil. Eddy currents lead to production of unwanted heat and therefore there is need to sufficiently cool the coil. Also, the energy source must be protected during reverse polarity of resonance. This requires using protective circuits which consume significant amounts of energy.
The currently used magnetic stimulation devices mostly consist of one magnetic field generating device, a capacitor parallel to a power source and a switching device in series to the power source. Further such topology requires a snubbering device, such as diode or RC snubbering circuit, for protecting the energy source during the reverse polarity of resonance. The use of a snubbering device causes high energy losses. The magnetic stimulation device wastes a lot of energy because of low efficiency due to significant electric losses while generating the time-varying magnetic field. Therefore these devices generate magnetic impulses ineffectively.
Current magnetic aesthetic methods are limited in key parameters which are repetition rate and/or magnetic flux density. All known methods use low values of magnetic flux density and/or low repetition rates which does not allow satisfactory enhancement of visual appearance. As a result, new methods are needed to enhance the visual appearance of the patient.
Magnet therapy uses the influence of magnetic flux on biological tissue. Electric current is induced in the tissue due to voltage change which causes a polarization of the cell membrane. One of fundamental phenomenon of electric current in biological tissue is a transfer of neural excitation or muscle contraction. The intensity of the effect is dependent on the magnetic flux density, repetition rate of the pulses, pulse time duration or envelope of the stimulation signal.
The currently used aesthetic applications don't provide any treatment combining the effect of time-varying magnetic field treatment and conventional treatment, e.g. treatment by electromagnetic field such as radiofrequency treatment. The currently used radiofrequency treatment includes many adverse events such as non-homogenous thermal temperature, insufficient blood and/or lymph flow during and/or after the treatment. Additionally several adverse event such as panniculitis may occur after the treatment.
The present methods and devices as described below produce a time varying magnetic field for patient treatment which better optimizes energy use, increases the effectiveness of the treatments and provide a new treatment. The magnetic pulses may be generated in monophasic, biphasic or polyphasic regimes. In a first aspect, the device has one or more coils; a switch; an energy storage device and a connection to an energy source. The coil may be made of insulated wires with a conductor diameter less than 3 mm even more preferably less than 0.5 mm and most preferably less than 0.05 mm. Smaller diameter and individual insulation of the wires significantly reduces self-heating of the coil and therefore increase efficiency of magnetic stimulation device. The coil may be flexibly attached in a casing of device. The casing may comprise a blower or blowers which ensure cooling of the coil.
The present methods provide new aesthetic applications for focused remodeling of the patient's body. The coil of the magnetic stimulation device may be flexibly attached to casing of the device. The blower or blowers may be arranged to blow air on both sides of coil. Optionally, the coil may be a flat type coil.
The method may provide a non-invasive transfer of a stimulation signal from an applicator to biological structure to evoke the action potential of biological structure.
The method of treating a biological structure uses a combination of non-invasive methods for enhancing human appearance. The invention utilizes electromagnetic field. Methods may be used for targeted remodeling of adipose tissue, focused treatment of cellulite, body contouring, skin tightening or skin rejuvenation. The invention relates to focused heating of the target tissue by electromagnetic waves, whereas the effect of focused heating of the target tissue is amplified by the effect of a magnetic treatment.
In a first aspect, a method provides stimulation of biological structure using magnetic field at repetition rates exceeding 50 Hz for purpose of at least a partial muscle contraction.
In further aspect, a neuromuscular plate and/or the nerve innervating the neuromuscular plate is stimulated and at least partial muscle contraction is provided.
The magnetic treatment induces the muscle contraction at higher repetition rates and the contraction is stronger. Therefore the treatment is more efficient for reducing the number and/or volume of adipocytes and enhancing the visual appearance of the treated body region via targeted muscle contraction. Further the temperature homogeneity of is improved. Additionally, strong muscle contractions at higher repetition rates cause mechanical movement of all the layers in proximity of the contracted muscle. The methods therefore cause remodeling and/or neogenesis of the collagen and elastin fibers.
In another aspect, the stimulation utilizes non-invasive and/or contactless transfer of the stimulation signal from an applicator to biological structure to evoke the action potential of the biological structure to induce at least partial muscle contraction. The applicator may include a source of magnetic field e.g. a coil.
In another aspect of the invention the repetition rate may exceed the frequency resolution of the structure. The magnetic flux density of the stimulation signal may increase over time. Therefore the envelope of resulting stimulation signal is increasing and it is perceived by the stimulated biological structure as a continuous stimulation signal instead of plurality of discrete stimuli. The envelope may be preferably triangular and other shapes may be used as well. This method is effective for stimulation of denervated muscle.
The envelope may be generated by time-varying magnetic flux density and/or repetition rate and/or impulse duration.
The muscle tissue is selectively stimulated and the magnetic flux density of the stimulation may be adjusted based on the patient's feeling and/or needs. Treatment time is shortened due to selective stimulation of muscles. Additionally, the treatment may be non-invasive or even contactless due to the high value of magnetic flux density. Invasive methods may be used as well. The patient may be treated without the necessity of taking clothes off. The method reduces patient discomfort.
The present methods may be used for enhancing visual appearance of body areas including adipose tissue reduction, muscle toning, muscle shaping, body contouring, body shaping, skin tightening, cellulite treatment, circumferential reduction, breast enhancement and/or lip enhancement.
The methods enable new treatments by magnetic and/or electromagnetic field. The repetition rate of the magnetic field is in the range of 1 to 300 Hz with high magnetic flux density up to 7 Tesla (equivalent to 70000 Gauss). The frequency of the electromagnetic field is 13.56 or 40.68 or 27.12 MHz or 2.45 GHz.
The present invention provides a new approach in determining the parameters of biological structure treatment.
According to the first aspect of the invention the magnetic stimulation device monitors the stimulation energy based on the current value of an operation parameter and/or the operation parameter waveform of one period.
According to still another aspect of the invention the control unit may calculate optimal flow of the cooling medium based on the treatment parameters, transition thermal characteristic of the magnetic stimulation device and/or the cooling medium temperature and significantly reduce the noise of the cooling system.
According to still another aspect of the invention the control unit may optimize the treatment parameters based on the current value of operation parameters and a transition thermal characteristic of the magnetic stimulation device.
The present invention relates to device and methods for treating a patient by a magnetic and/or electromagnetic field. The application of the magnetic and/or electromagnetic field is provided by at least one energy delivery element. The device may be used for treatment or focused remodeling of adipose tissue by reducing number and/or value of lipid-rich cells.
The present device and methods as described below provide combined treatment by high power magnetic and/or electromagnetic field, particularly radiofrequency treatment. The combined treatment may be provided by one device using at least one coil for providing both treatments, the magnetic and even the electromagnetic treatment.
The device may include a plurality of energy delivery elements. The positioning of the plurality of the energy delivery elements may be controlled by a mathematic method including monitoring a characteristic quantity of an operation parameter.
The energy delivery element may be used as an energy source for another functional part of an applicator, e.g. a blower, or for providing energy to light emitting device providing still another treatment.
Conventional non-invasive and/or invasive aesthetic medicine treatment methods refer to aesthetic applications based on application of mechanical waves, e.g. acoustic wave, ultrasound or shock wave therapy; or electromagnetic waves, e.g. radiofrequency or diathermy treatment or light treatment, such as intense pulsed light or laser treatment; or mechanical stimulation, e.g. positive or negative pressure, rollerball, massage etc.; or thermal treatment, e.g. cryotherapy; or electrotherapy method; or mesotherapy method and or any combination thereof.
Thermal treatment refers to treatment by heating or cooling, e.g. a cryotherapy treatment.
Biological structure is at least one neuron, neuromuscular plate, muscle fiber, adipose cell or tissue, collagen, elastin, pigment or skin.
Remodeling target biological structure refers to reducing the number and/or volume of the adipocytes by apoptosis and/or necrosis, cellulite treatment, body shaping and/or contouring, muscle toning, skin tightening, collagen treatment, skin rejuvenation, wrinkle removing, reducing stretchmarks, breast lifting, lip enhancement, treatment of vascular or pigmented lesions of the skin or hair removing.
Stimulation signal refers to a magnetic flux density inducing an electric current in the biological structure.
Body region includes muscle or muscle group, buttocks, saddlebags, love handles, abdomen, hips, thighs, arms, limb and/or any other tissue.
Muscle includes at least one of muscle fiber, muscle tissue or group, neuromuscular plate or nerve innervating the at least one muscle fiber.
Deep muscle refers to a muscle that is at least partly below superficial muscles and/or to the muscle that is covered by a thick layer of other tissue, e.g. mostly adipose tissue and/or the skin, with thickness 0.5, 1, 2, 3, 4, 5 or more centimetres.
Adipose tissue refers to at least one lipid rich cell, e.g. adipocyte.
Bolus refers to a layer of fluid material, e.g. water or fluid solution of ceramic particles, preferably enclosed in a flexible sac made of biocompatible material.
Impulse refers to a single magnetic stimulus.
Pulse refers to a period of treatment by a magnetic field of at least one magnetic stimulus and time duration of no stimulation, i.e. time duration between two impulses from rise/fall edge to next rise/fall edge.
Repetition rate refers to frequency of firing the pulses; it is derived from the time duration of a pulse.
Envelope refers to shape of curve created by connection of induced energy amplitudes stimulating the target biological structure.
Neural structure includes at least one neural cell, a neuron, a neuroglia, a Schwann cell, a nerve, a neural tissue, spine or brain.
Operation parameter refers to voltage, current or magnetic flux density.
Induced energy refers to energy stimulating the target neural structure, the amount of induced energy corresponds to repetition rate, magnetic flux density and impulse duration.
Hardware panel refers to at least one hardware component used for controlling the optical and/or magnetic treatment. The hardware panel includes at least one of input interface for inputting treatment parameters by an operator and processing unit for controlling the optical and/or magnetic treatment.
Treatment parameters refer to one or more of: magnetic flux density, repetition rate, impulse duration, wavelength, power flux density and/or energy flux density of the optical waves, pulse width, modulation, treatment protocol or treatment duration.
Optical waves include electromagnetic waves from ultraviolet, visible and infrared spectrum ranges, i.e. the waves of wavelength in the range of 190 to 13000 nm.
Optical waves generating device refers to laser or laser diode, light emitting diode (LED), electric discharge source, incandescent source, fluorescent source, luminescent source, electroluminescent source etc.
Optical treatment refers to treatment by optical waves.
The present invention provides a magnetic stimulation device and method of controlling the magnetic stimulation device using a plurality of magnetic field generating devices.
The magnetic stimulation device may include the at least one applicator, the at least one energy source and at least two magnetic field generating devices. However, in an alternative embodiment the magnetic stimulation device may include a plurality of applicators and/or plurality of energy sources. The plurality of applicators may be used for treatment of at least two cooperating muscle groups with different treatment effects. In an exemplary application e.g. the triceps brachii muscle may be treated to achieve myostimulation effects and the biceps brachii muscle may be treated to achieve myorelaxation effects.
The magnetic stimulation device may include a plurality of applicators. The applicator includes at least one magnetic field generating device which may be movable. The benefit of this embodiment is that the movement and/or positioning of the plurality of the applicators may be independent. Hence different parts of the patient's body may be treated simultaneously. Therefore the total treatment time is reduced and patient's downtimes are reduced as well. The movement of the at least one applicator may be automatic so that manual manipulation may not be needed. The movement of the at least one applicator may follow a predetermined trajectory or it may be random. In an alternative embodiment the movement of the plurality of applicators may be synchronized.
The plurality of applicators may be positioned with respect to each other in one plane; in at least two mutually tilted planes defined by convex or concave angles, or perpendicular to each other; or in at least two parallel planes. The angles of the planes may be adjusted by an operator following the patient's needs. In an alternative embodiment the patient may be positioned in the intersection of the magnetic fields generated by the plurality of magnetic field generating devices.
The benefit of this application may be treatment of a plurality of cooperating muscles, such as agonist and antagonists, e.g. one muscle may be stimulated to achieve strengthening effect and on the other side the other muscle may be stimulated to achieve myorelaxation effect.
Using a plurality of magnetic field generating devices provides faster treatment. Large and/or different areas may be treated in shorter time. Using a plurality of applicators allows different areas and/or target biological structures to be stimulated at the same time. The movement of the at least one applicator may automatically follow a predetermined trajectory. Hence manual manipulation is not needed. Furthermore the shape of the generated magnetic field may be adjusted by an operator.
The applicator including a coil which is preferably flat for magnet therapy is placed proximate to the patient's body. The magnetic flux is applied into the biological structure. The electric current is induced and stimulates the neuromuscular plate. Due to the stimulation at least a partial muscle contraction is caused.
In one aspect of the invention a magnetic stimulation device includes at least one applicator and a plurality of magnetic field generating devices. The magnetic field generating device may be air-cooled or cooled by any other fluid media.
Repetition rate and/or magnetic flux density may vary during the treatment protocol. Further the magnetic stimulation signal may include several periods of stimulation signal of different repetition rates, therefore the modulation of the signal is in repetition rate domain. The stimulation signal may include several periods of stimulation signal of different magnetic flux densities, therefore the modulation of the signal is in magnetic flux density domain. In yet another approach the envelope of the stimulation signal may be modulated by combinations of repetition rate domain, magnetic flux density domain or impulse duration domain.
Various envelopes of the stimulation signal and waveform, e.g. pulse, sinusoidal, rectangular, square, triangular, saw-tooth, trapezoidal, exponential etc. for the purpose of muscle stimulation may also be used, and is not limited to recited shapes of stimulation signals.
A magnetic treatment device may include at least one energy source and/or connection to the energy source, at least one switching device, at least one energy storage device, e.g. a capacitor, and at least one magnetic field generating device e.g. a coil.
The magnetic stimulation device may include at least one energy source, at least one energy storage device (e.g. a capacitor), at least one magnetic field generating device (e.g. a coil) and at least one switching device. The magnetic field generating device may include a core, however in a preferred embodiment the magnetic field generating device includes no core. The switching device may be any kind of switch such as diode, MOSFET, JFET, IGBT, BJT, thyristor or a combination of them.
The at least one magnetic generating device may be in various shapes to enhance a variability of magnetic field profile. The shape of the magnetic field generating device may be circular, semicircular, rectangular, “
Large areas may be stimulated by the plurality of the magnetic field generating devices. The plurality of magnetic field generating devices may generate a plurality of independent magnetic fields, e.g. two magnetic field generating devices may generate two magnetic fields with two peaks of magnitude of magnetic flux density.
The plurality of magnetic field generating devices may be operated at various treatment parameters and/or operation modes to provide various treatment effects for the patient during the treatment, e.g. myostimulation, myorelaxation, analgesic effect or aesthetic effects such as adipose tissue reduction, muscle toning, muscle shaping, body contouring, body shaping, skin tightening, cellulite treatment, circumferential reduction, breast enhancement and/or lip enhancement.
where: PEDDY is power loss per unit mass (W kg−1); BP is the peak of magnetic field (T); f is frequency (Hz); d is the thickness of the sheet or diameter of the wire (m); k is constant equal to 1 for a thin sheet and 2 for a thin wire; ρ is the resistivity of material (Ω·m); D is the density of material (kgm3).
The individual insulation of each wire reduces eddy currents. The individually insulated wires may be wound either one by one or in a bundle of individually insulated wires so as to form a coil, which will serve as a magnetic field generator. The coil provides an improvement in the efficiency of energy transfer in the LC resonant circuit and also reduces or eliminates unwanted thermal effects.
The coil may have a planar coil shape where the individually insulated wires may have cross-section wires with conductor diameter less than 3 mm even more preferably less than 0.5 mm and most preferably less than 0.05 mm. The wires are preferably made of materials with higher density and higher resistivity e.g. gold, platinum or copper. The diameters of the single wires should be minimal. On the other hand the total diameter should be maximal because of inverse proportion between the cross-section of all wires forming the coil and the electrical resistance. Therefore the ohmic part of the heat is then lower. Eq. 2 describes power loss of the coil:
Where: PR is the power loss heat dissipation (W); ρ is the resistance (Ω·m); l is the length of wire (m); S is the surface area (m2); I is the current (A) and m is 1 kg of wire material.
Total power loss is (Eq.3):
PTOT=PEDDY+PR. Eq. 3
Where: PTOT is the total power losses (Wk·g−1); PEDDY is the power dissipation of eddy currents (W·kg−1); PR is the power loss heat dissipation (W·kg−1).
Dynamic forces produced by current pulses passing through the wires of the coil cause vibrations and unwanted noise. The individual insulated wires of the coil may be impregnated under pressure so as to eliminate air bubbles between the individual insulated wires. The space between wires can be filled with suitable material which causes unification, preservation and electric insulation of the system. Suitable rigid impregnation materials like resin, and elastic materials like PTE can be also used. With the coil provided as a solid mass, the vibrations and resonance caused by movements of the individual insulated wires are suppressed. Therefore noise is reduced.
The coil may be attached to the case of the applicator, such as a hand held applicator of the magnetic stimulation device; build-in applicator in e.g. chair, bed; or stand-alone applicator e.g. on mechanical fixture. The attachment may be provided by an elastic material e.g., silicone, gum; or other flexible manner. Connection with the coil of the applicator's case can be ensured by several points. The several fastening points ensure the connection of the coil to the casing by flexible material so that the main part of the coil and the main part of the casing of applicator are spaced apart. The spacing should be at least 0.1 mm so that air can easily flow. The gap between the coil and the casing can be used either for spontaneous or controlled cooling. The coil may optionally be connected to the case of the applicator by only one fastening point. The fastening points eliminate vibrations of wires which could be transferred to housing of the applicator and therefore reduce noise of the magnetic stimulation device.
The magnetic stimulation device may be cooled by a fluid, e.g. by a liquid or a gas. In the preferred embodiment the magnetic stimulation device is cooled by air.
The fastening points 3 connect the coil to the case of the applicator in at least one point. The fastening points 3 maintain the coil and the main part of the case of the applicator spaced apart so that fluid (which may be air or any liquid) can flow between them. At least one blower 4 can be placed around the circumference of the coil, or perpendicular to the coil. The blower can be any known kind of device for directing the fluid e.g. outer air directed into the case of the applicator. This arrangement of the blower allows air to bypass the coil from upper and lower (patient's) sides. In still another embodiment the outer air can be cooled before directing into the case. The blower can have an inlet placed around the circumference of the coil for injecting air, to remove heat from the coil. A connecting tube (not shown) can ensure connection of the applicator 5 with the energy source and/or control unit of magnetic stimulation device. The connecting tube may also contain a conduit of the fluid.
The arrows 6 indicate the air flow through the applicator. This arrangement of the blower allows the air to bypass the coil from upper and lower (patient's) side. Outlet may be preferably placed on upper side of the casing. By placing the blower around the circumference of the coil instead of on the top/below the coil, the blower 4 does not interfere with the magnetic flux peak and therefore its lifespan and reliability is increased.
The fastening points 22 connect the coil to the case of the applicator in at least one point. The fastening points 22 maintain the coil and the main part of the case of the applicator spaced apart so that fluid (which may be air or any liquid) can flow between them. At least one blower 24 can be placed around the circumference of the coil, or perpendicular to the coil. The blower can be any known kind of device for directing the fluid e.g. outer air directed into the case of the applicator. This arrangement of the blower allows air to bypass the coil from upper and lower (patient's) sides. In still another embodiment the outer air can be cooled before directing into the case. The blower can have an inlet placed around the circumference of the coil for injecting air, to remove heat from the coil. A connecting tube (not shown) can ensure connection of the applicator 25 with the energy source and/or control unit of magnetic stimulation device. The connecting tube may also contain a conduit of the fluid.
The arrows 26 indicate the air flow through the applicator 25. This arrangement of the blower allows the air to bypass the coil from upper and lower (patient's) side. Outlet may be preferably placed on upper side of the casing. By placing the blower around the circumference of the coil instead of on the top/below the coil, the blower 24 does not interfere with the magnetic flux peak and therefore its lifespan and reliability is increased.
In an alternative embodiment cooling may be provided by a member using thermoelectric effect, e.g. a Peltier cooler. Alternatively, cooling may be provided by Stirling engine cooling system.
The state of art magnetic stimulation device achieves magnetic flux density of a few tenths to several ones of Tesla (1 Tesla is equivalent to 10000 Gauss). To achieve this level of magnetic flux density, the energy source used generates sufficient voltage. This voltage can reach thousands of volts. In
During second half-period of LC resonance, the polarity on the energy storage device 13 is reversed in comparison with the energy source 14. In this second half-period, there is a conflict between energy source 14, where voltage on positive and negative terminals is typically thousands of Volts. The energy storage device 13 is also charged to the positive and negative voltage generally to thousands of Volts. As a result, there is in the circuit, consequently, twice the voltage of the energy source 14. Hence the energy source 14 and all parts connected in the circuit are designed for a high voltage load. Therefore, the protective resistors and/or protection circuitry 15 must be placed between energy source 14 and energy storage device 13. Disadvantage of state of art solution is large amount of energy transformed to undesired heat in protective resistors and/or protection circuitry 15.
The switch 18 can be any kind of switch such as diode, MOSFET, JFET, IGBT, BJT, thyristor or their combination. Depending on the type of component the load of energy source 19 is reduced to a few Volts, e.g., 1-10 volts. Consequently, it is not necessary to protect the energy source 19 from a high voltage load, e.g., thousands of Volts. The use of protective resistors and/or protection circuits is reduced or eliminated. The present designs simplify the circuits used, increase efficiency of energy usage and provide higher safety.
The treatment by the magnetic stimulation device may be in different operation modes. One operation mode may generate a plurality of impulses 51 at one time within the pulse 52 as illustrated in
The magnetic stimulation device may generate a plurality of the impulses 51 by the magnetic field generation devices L1, L2, . . . LN at one time within the pulse 52. This operation mode is illustrated in
The switching device 607-609 may be switched separately, with the magnetic field generated by separate magnetic field generating devices.
In an alternative embodiment any switching device may be switched in combination with at least one other switching device.
The active magnetic field generating devices are the magnetic field generating device in the closed loop of the electric circuit. For example if the number of active magnetic field generating devices is 2 and the inductances of the magnetic field generating devices are the same, then the value of magnetic flux density for each magnetic field generating device is one-half of the magnetic flux density which would be reached by one active magnetic field generating device with the same parameters and conditions, e.g. inductance, resistance, frequency, voltage. The total equivalent inductance of the magnetic stimulation device may be changed by switching a plurality of switching devices into a closed electric circuit. Therefore the impulse duration may be adjusted by adjusting the inductance. The value of total equivalent inductance (Ltotal) may be determined by Equation 4.
The magnetic stimulation device may generate a plurality of impulses 51 generated by the magnetic field generation devices L1, L2, . . . LN at different times within the pulse 52. This operation mode is illustrated in
In the example of
The benefit of this exemplary embodiment is the time independency of the impulses generated by the separate magnetic field generating devices. However, the switching devices may be synchronized to generate the impulses at one fixed time within the pulse or both operation modes may be combined using this embodiment. Another benefit of this embodiment is the possibility of providing various treatments by a plurality of magnetic field generating devices. Various treatments may provide various effects for the patient, e.g. stimulation, such as myostimulation, pain alleviation or myorelaxation.
The impulses generated by the separate magnetic field generating devices are time independent. However, the switching devices may be synchronized to generate the impulses at one time within the pulse or both operation modes may be combined.
The inductance of magnetic field generating devices in each embodiment may vary. The capacitance of the energy storage devices in each embodiment may vary as well. The impulse duration may be variable and/or the magnetic flux density generated by different magnetic field generating devices may vary as well.
The device can be used for treatment/successive treatments in continual, interrupted or various duty cycle regime. The duty cycle may be higher than 10%, which means interrupted regime with the ratio up to 1 active to 9 passive time units. The ratio may possibly change during the therapy. The device enables operation defined by the peak to peak magnetic flux density on the coil surface at least 3 T, more preferably at least 2.25 T, most preferably at least 1.5 T at repetition rates above 50 Hz, more preferably at repetition rates above 60 Hz, even more preferably at repetition rates above 70, most preferably at repetition rates above 80 Hz with treatment/successive treatments lasting several seconds or longer, for example, for at least 5, 10, 30, 60, 120 or 240 seconds, or longer. The total power consumption is below 1.3 kW and the width of pulses is in the range of hundreds of μs.
The device enables achieving repetition rates above 100 Hz, more preferably repetition rates above 150 Hz, most preferably repetition rates above 200 Hz with the magnetic flux density providing a therapeutic effect on neurons and/or muscle fibers and/or endocrine cells (e.g. at least partial muscle contraction, action potential in cell). Based on achievement of repetition rates in order of few hundreds the device also enables assembling the magnetic pulses into the various shapes (e.g. triangular, rectangular, exponential), with the shape widths from 6 ms to several seconds or longer.
Alternatively the magnetic field generating device may generate a static magnetic field. The magnetic field generating device generating the static magnetic field may be e.g. a permanent magnet or electromagnet. The coil may be powered by a power source, a transformer and/or an energy storage device. The magnetic field may be applied as time-varying magnetic field by movement of the magnetic field generating device. Alternatively the magnetic field generating device may be switched on and off.
During last few decades patient have not only wanted to be in good health, they have also wanted to look well, i.e. to be well shaped, without any unattractive fat and to have a young appearance, without wrinkles, stretchmarks or sagging breasts. This has resulted in a progressive evolution of invasive aesthetic methods such as surgical removing of fat and remodeling the human body by invasive and potentially dangerous methods, e.g. liposuction or inserting implants into human body. The side effects of invasive methods may be scars, swelling or bruising. The side effects resulted in the rapid progress in non-invasive method, e.g. lipolysis or removing skin imperfections. One example of the last few years may is rapid increase of patients' demand for enhancing the visual appearance of buttocks. This has resulted in a higher percentage of these operations by plastic surgeons.
Electric current may be induced in the treated biological structure during pulsed magnetic treatment. Due to the high value of magnetic flux density the biological structure may be targeted and treated more specifically. A distribution of magnetic field is uniform in the biological structure. Particles (e.g. atoms, ions, molecules etc.) in the biological structures are influenced by the magnetic field and permeability of a cell membrane may also increase.
Due to increased permeability of the cell membrane, the pulsed magnetic treatment may induce following effects: at least partial muscle contraction; reduction of adipose tissue−volume and/or number of the adipose cells; neogenesis and/or remodeling of collagen and/or elastin fibers. Further magnetic treatment may improve circulation of blood and/or lymph and improve local and/or adipose tissue metabolism.
With the present methods, factors for enhancing visual appearance of the body include: treatment of major muscle, e.g. gluteus maximus; treatment of deep muscle which may be enabled by high value of magnetic flux density; non-contact application of magnetic flux density, it may be applied even through clothing; stronger muscle contraction due to higher value of magnetic flux density; higher-quality of muscle targeting; treatment may not be influenced by small movements during treatment; treatment time duration may be shortened due to high value of magnetic flux density and/or higher repetition rate; no delays may occur.
It is to be understood that the method is not limited to the particular applications and that the method may be practiced or carried out in various ways.
Present method may be applied for enhancing the visual appearance of body parts including or proximate to major muscle structures. Further the method may be applicable for enhancing the visual appearance of patients with high value of BMI. A patient with BMI of at least 18, preferably at least 25, more preferably at least 30, most preferably at least 35 or more may be preferably treated by the recited methods. The thickness of patient's SWAT and/or VWAT may be at least 0.1, 0.5, 10, 15, 25, 50, 75, 100 or more. The patient may be preferably healthy without any life-threatening conditions such as circulatory system disease, e.g. deep vein thrombosis. The present method is not limited to the application of the treatment to major muscle. Muscles other than major muscles may be treated as well.
The applicator of magnetic treatment may be placed proximate to the patient's body. As used here, proximate to includes both contactless and in actual contact with the skin of the patient. The muscles may be selectively treated and the magnetic flux density may be adjusted following the patient's feeling or needs. The treatment time may be shortened due to selective treatment of the correct muscles. Additionally, due to the high value of magnetic flux density, the muscle may be treated more effectively. Further, the treatment may be non-invasive or even preferably contactless due to the high value of magnetic flux density. The patient may be treated without removing clothing, reducing patient discomfort. Additionally, following the high efficiency of the muscle contraction the collagen and/or elastin fibers above the muscle structure may be remodeled, hence the visual appearance may be enhanced.
The collagen constitutes around 30% of proteins. Treatment by time-varying magnetic field may induce the neocollagenesis. The collagen may be treated by various repetition rates, e.g. in the range of 1 to 250 Hz, more preferably in the range of 10 to 100 Hz, or up to 700 Hz. However, the repetition rate of 25 Hz may be preferably used because the results achieved by stimulation of repetition rate of 25 Hz were the most significant. High value of magnetic flux density may improve the neocollagenesis more than low value of magnetic flux density. Hence the magnetic flux density may be at least 0.5 T, more preferably 1 T, most preferably at least 2 T, or up to 7 T.
The position of the patient may correspond to treated biological structure and/or body region. The patient may be treated in seated position. Alternatively, the patient may be treated in lying position, e.g. in supine position. Treatment in lateral recumbent position may be also applicable. Patient may be in prone position as well.
In the preferred application the treatment method may be applied to body regions prone to cellulite and/or prone to adipose accumulation, such as thighs, saddlebags, buttocks, abdomen, region of love handles, region of bra fat or arm. The adipose accumulation may be influenced by number and/or volume of adipose cells.
The magnetic treatment of the biological structure may have various applications for enhancing visual appearance of the contour of a body region. High density magnetic field reaching such values which may be used for: adipose tissue reduction, wherein the adipose tissue reduction may be achieved by reduction of number and/or volume of adipose cells; muscle toning, wherein the muscle appearance enhancement may be achieved by adipose tissue reduction with no muscle bulking; muscle shaping, wherein the muscle appearance enhancement may be achieved by adipose tissue reduction and/or muscle bulking; body contouring, wherein the silhouette appearance enhancement may be achieved by adipose tissue reduction with no muscle bulking; body shaping, wherein the silhouette appearance enhancement may be achieved by adipose tissue reduction and/or muscle bulking; skin tightening, wherein the skin appearance enhancement may be achieved by obtaining smoother and younger appearance, including wrinkles reduction; cellulite treatment, wherein the appearance enhancement may be achieved by adipose tissue reduction, muscle contraction and/or elastic fibers neogenesis; circumferential reduction, wherein the reduction may be achieved by adipose tissue reduction and/or the muscle bulking; breast enhancement, wherein the appearance enhancement effect may be achieved by elevation or shape modification; lip enhancement, wherein the lip appearance enhancement may be achieved by obtaining fuller and firmer appearance. The body region may be reduced in overall size. Further aesthetic effects may be achieved, e.g. connective tissue improvement, fat disruption, muscle volumization, muscle forming, muscle toning, muscle remodeling, contouring, sculpting or body sculpting.
The one approach is stimulating central neural system or peripheral neural structure and determining the feedback, e.g. muscle contraction.
Neural system includes central neural system and/or peripheral neural system.
In still another application of the invention, the time-varying magnetic field may be used for stimulation of neural structure to cause muscle stimulation. The muscle stimulation may occur during stimulation by envelopes of repetition frequencies below 100 Hz.
In the methods described, the magnetic stimulation device may or may not include a magnetic core. The magnetic stimulation device may be cooled by fluid, e.g. by air, water or oil. Total power consumption of the magnetic stimulation device may be below 1.3 kW. The power of the magnetic stimulation device may be at least 150, 250 or 500 W to generate a magnetic flux density sufficient to induce at least muscle contraction. A magnetic stimulation device as described in the US patent application No. 14,789,156 or US patent application No. 14,789,658, incorporated herein by reference, may be used.
The applicator for magnetic treatment may be placed proximate to the patient's body. The magnetic flux density may be applied into the target biological structure. Electric current may be induced and treat the neuromuscular plate and/or the nerve innervating the at least one muscle fiber. The treatment may cause at least a partial muscle contraction.
The envelope may be generated on the basis that the biological structure, e.g. a nerve or at least one muscle fiber, is not able to distinct single pulses during the stimulation at higher repetition rates, e.g. exceeding 100 Hz, more preferably at least 150 Hz, even more preferably at least 200 Hz, most preferably at least 250 Hz, or up to 700 Hz.
Generally, at least two pulses are necessary to create a simple shape of the envelope, e.g. rectangular or trapezoid. However, the more complex envelope shape is the more pulses are needed. The induced energy (IE) stimulating the target neural structure is a function of repetition rate, magnetic flux density and/or impulse duration.
The envelope may consists of several impulses 51 called train. The number of pulses in one train varies in a range of at least 2 pulses to thousands of pulses. The repetition frequency of envelope is given by the envelope period, i.e. the envelope may include time with no stimulation as well. The envelope may consist of stimulation signals with various burst frequencies, e.g. 5, 10, 20, 50, or more Hz. The envelope may be generated by several modulation approaches.
Envelope may be generated by time-varying magnetic field of varying peak magnetic flux density hence the process is called magnetic flux density modulation (MFDM). The principle of MFDM is described in
Alternatively the envelope may be generated in repetition rate domain hence the process is called repetition rate modulation (RRM). The principle of RRM is described in FIGS. 12A and 12B. The magnetic flux density of each impulse 51 remains constants. The impulse duration remains constant as well. Therefore the induced energy for one pulse is constant. However, the repetition rate varies hence the time duration of each pulse varies with respect to the preceding pulse, see
According to still another aspect of the application, envelope may be generated in impulse duration domain. The principle of impulse duration modulation is shown in
The modulation approaches are not limited by exemplary waveform. Therefore the envelope may be rectangular, square, saw-tooth, trapezoidal, sinusoidal, exponential etc.
All the mentioned applications may be applied in constant repetition rate and/or repetition frequency manner. The envelope modulation or combination thereof is applicable as well.
Furthermore, the present invention discloses the advanced approaches in aesthetic applications, e.g. for cellulite treatment and/or body shaping. Combined methods of treatment by electromagnetic field and treatment by magnetic field are used. The electromagnetic field may include treatment by radiofrequency, infrared or optical waves. The magnetic treatment may be provided by permanent magnets, electromagnetic devices generating a static magnetic field or time-varying magnetic devices. In the preferred application the treatment by a pulsed magnetic field and radiofrequency treatment may be combined. However the application is not limited by the recited combination so the combined method may include magnetic treatment and any treatment by electromagnetic field, e.g. light treatment, IR treatment or treatment by radiofrequency waves, e.g. microwaves, short waves or long waves. The magnetic treatment may also be provided with thermal treatment, e.g. heating and/or cooling.
A device described in U.S. patent application Ser. No. 14/278,756 incorporated herein by reference may be used for application of the present methods. The device may exclude the balun transformer, or the balun transformer may be included in transmatch. The possible methods of treatment by combined methods are described below.
Magnetic treatment in combination with radiofrequency treatment may be applied by two independent treatment devices, e.g. one device for treating the biological structure by radiofrequency waves and second device for treating the biological structure by magnetic field. Both devices may have a separate applicator for treating the biological structure, or one applicator may be used by at least two devices, i.e. the applicator may be modular for a plurality of devices.
The device may include at least one HF frequency generator for providing energy for radiofrequency treatment and for providing energy for magnetic treatment. In an alternative embodiment, the device may include at least one HF frequency generator for providing energy for radiofrequency treatment and at least one other independent frequency generator for providing energy for magnetic treatment. The device may include plurality of applicators for providing separate radiofrequency or magnetic treatments to the patient.
In alternative embodiment the applicator may provide a combination of radiofrequency and magnetic treatment. In one embodiment, the applicator may include at least one radiofrequency electrode for providing radiofrequency treatment and at least one magnetic field generating device, e.g. a coil, for providing magnetic treatment. In another embodiment, the applicator may include at least one electrode for providing radiofrequency treatment and at least one magnetic field generating device providing magnetic treatment, wherein the at least one RF source provides energy for both at least one electrode and at least one magnetic field generating device.
In still another embodiment the at least one RF source may provide the energy for the at least one magnetic field generating device providing magnetic treatment wherein the at least one magnetic field generating device may be used as the at least one electrode. The essence is the far different stimulation frequencies which are used for RF treatment and magnetic treatment. The magnetic field generating device in the high frequency field is similar to the electrode. This enables the magnetic field generating device to be the electrode for radiofrequency treatment. In the preferred embodiment a flat coil may be used as the electrode.
The frequencies for the radiofrequency treatment may be in the range of ones of MHz to hundreds of GHz, more preferably in the range of 13 MHz to 3 GHz, most preferably around 13.56 or 40.68 or 27.12 MHz or 2.45 GHz. The term “around” should be interpreted as in the range of 5% of the recited value. The impulse frequencies for the magnetic treatment may be in the range of hundreds of Hz to hundreds of kHz, more preferably in the range of ones of kHz to tens of kHz, most preferably up to 10 kHz. However the repetition rate of the magnetic impulses may reach up to 700 Hz, more preferably up to 500 Hz, most preferably in the range of 1 to 300 Hz, e.g. at least 1, 5, 20, 30, 50, 100, 140 or 180 Hz. The magnetic flux density of the magnetic treatment may be at least 0.1, 0.8, 1, 1.5, 2, 2.4 or up to 7 Tesla on the coil surface (equivalent to 70000 Gauss). The treatment/successive treatments may last several seconds, e.g. at least 5, 10, 30, 60, 120 or 240 seconds, or longer, e.g. at least 20, 30, 45, 60 minutes. The impulse duration may be in the range of 3 μs to 10 ms or more, or alternatively 3 μs to 3 ms or alternatively 3 μs to 1 ms. The impulse duration may be e.g. 3, 10, 50, 200, 300, 400, 500, 625, 1000, 2000 or 3000 μs. The duty cycle of the stimulation may be at least 1:50, more preferably at least 1:40, even more preferably at least 1:20, most preferably at least 1:8 or up to 1:4. The magnetic stimulation device may emit no radiation.
A derivative of the magnetic flux density is defined by Equation 5.
where: dB is magnetic flux density derivative [T]; dt is time derivative [s].
The maximal value of the magnetic flux density derivative may be up to 5 MT/s, preferably in the ranges of 0.3 to 800 kT/s, 0.5 to 400 kT/s, 1 to 300 kT/s, 1.5 to 250 kT/s, 2 to 200 kT/s, 2.5 to 150 kT/s. In exemplary applications the maximal value of the magnetic flux density derivative may be at least 0.3, 0.5, 1, 2.5, 3.2, 5, 8, 10, 17, 30 or 60 kT/s. The value of magnetic flux density derivative may correspond to induced current within the tissue.
The magnetic flux density derivative may be determined within the entire period of the magnetic signal and/or in any segment of the magnetic signal.
Alternatively the treatment device may include no deep muscle diathermy device for heating the target biological structure. The treatment preferably may include no electrode which may enable heating the biological structure in contact mode.
Cellulite is an effect of skin change resulting in orange peel appearance. The cause of the cellulite is orientation of collagen fibers in so called “fibrous” septae. The fibrous septae contract and harden over time creating a dimple effect. Additionally, blood and lymphatic vessels lack circulation due to the contraction and hardening of the septae. The lymph flow may be blocked resulting in swelling. Another cause of cellulite may be adipose cells protruding to dermis. Cellulite may be treated by the recited methods.
One application of time-varying magnetic field for enhancing the visual appearance of body region may be treatment of a muscle by magnetic flux density for reducing the cellulite. The magnetic flux density may be delivered through the skin to the neuromuscular plate and/or nerve innervating at least one muscle fiber. The electric current may be induced in the target biological structure causing at least partial muscle contraction. The at least partial muscle contraction may cause the movement of the skin and all the biological structures subtending epidermis. Additionally, the at least partial muscle contraction may improve blood circulation by itself, or via the movement of the muscle in the vicinity including fibrous septae. Additionally, blood and/or lymph circulation may be improved in the layers subtending epidermis since the muscle contraction may move the fibrous septae. Also local and/or adipose tissue metabolism may be improved.
The magnetic treatment may be used for improving the lymph flow.
The lymph flow may be improved by at least partial muscle contraction which may provide effect similar to manual massage. The improved lymph flow may improve local metabolism and/or immune system. The improved lymph flow may contribute to purer lymph due to faster delivery of the lymph to the lymph nodes where the lymph may be cleared.
The present method may provide a massage effect via the treatment which may be caused by the at least partial muscle contraction. Therefore the massage effect may be achieved by contactless methods instead of manual massage techniques or soft tissue techniques. The massage effect may improve lymph circulation.
In another aspect, improvement of functionality and/or the appearance of the muscle may be achieved with results similar to body exercise. The results may be achieved by application of high magnetic flux density to the body region and inducing at least partial muscle contraction. Higher values of magnetic flux density applied may result in a stronger muscle contraction. The patient may feel firmer and tighter.
With the present method muscle contractions induced by the applied magnetic flux density may help to tone the muscle providing a more attractive appearance. As the muscle structure is treated by time-varying magnetic field the entire limb may be moved due to the high power of the magnetic treatment. Nevertheless, the method is not limited to the applications to the limbs and the method is able to treat any muscle, e.g. gluteus maximus or any muscle/deep muscle to induce body contouring and/or body shaping effect and fat burn. Additionally, shortened and/or flabby muscles may be stretched. The physical fitness of the patient may be improved as well.
The magnetic field may treat various body regions, e.g. thighs, buttocks, hips, abdomen or arms. The muscles may be shaped to enhance visual appearance of the treated body region. The body part may obtain enhanced visual appearance of its contour.
The magnetic field may treat at least one muscle of lower limb, particularly the parts which are prone to cellulite such as thighs or saddlebags. The time-varying magnetic field may induce at least partial muscle contraction in different muscle and/or muscle group. Following the position and/or orientation of the magnetic field generating device the anterior, posterior and/or medial compartment of the thigh may be treated. The anterior compartment includes sartorius muscle, rectus femoris muscle, vastus lateralis muscle, vastus intermedius muscle, vastus medialis muscle. Posterior compartment includes biceps femoris muscle, semitendinosus muscle and semimembranosus muscle. Medial compartment includes pectineus muscle, external obturator muscle, gracilis muscle, adductor longus muscle, adductor brevis muscle and adductor magnus muscle.
The treatment may cause circumferential reduction of thighs. Further the muscle may obtain enhanced visual appearance, thigh may be well-shaped. Thigh contour may be enhanced as well.
The at least one surrounding body region may be treated as well, e.g. buttocks.
The ocular muscles may be treated by focused treatment of magnetic flux density exceeding 0.1 T. The treatment may induce the at least partial muscle contraction of the ocular muscle which may be exercised to be strengthened.
The applicator may be placed within proximity of the patient's treated area. The applicator may be fixed to the patient. Alternatively the correct position may be provided by a mechanical arm and/or adjustable applicator. The applicator may be made of adhesive and/or high friction material at least on contact surface with the patient.
The magnetic field may be generated with a low repetition rate such as 1 Hz for a predetermined period of time, e.g. 30 seconds, sufficient for setting the applicator to a correct position where the treatment is most effective. During the period the magnetic flux density may be adjusted following the patient's needs to induce muscle contraction sufficiently strong and comfortable for the patient.
The treatment may start a treatment protocol. The treatment protocol may include a set of predetermined treatment sequences of predetermined repetition rates applied for predetermined time periods. The sequences may be repeated and/or adjusted following the patient's need. The sequence may include a repetition rate in the range of 1 to 100 Hz, preferably in the range of 2 to 90 Hz, more preferably in the range of 5 to 50 Hz, most preferably in the range of 10 to 45 Hz. The sequences may last at least 30, 45, 60, 90, 120 or up to 300 seconds.
Alternatively the treatment may include the only the treatment protocol without applying the magnetic field of low repetition rate. The correct position of the applicator and/or adjusting the magnetic flux density may be adjusted during the first sequence of the treatment protocol.
Repetition rate and/or magnetic flux density may vary during the treatment protocol. Further the magnetic stimulation signal may include several periods of stimulation signal of different repetition rates, therefore the modulation of the signal is in repetition rate domain. The stimulation signal may include several periods of stimulation signal of different magnetic flux densities, therefore the modulation of the signal is in magnetic flux density domain. In yet another approach the envelope of the stimulation signal may be modulated by combinations of repetition rate domain and magnetic flux density domain.
In one application, the treatment may induce the same effect as muscle exercising of buttocks. During the treatment of buttocks the magnetic field may be targeted to treat of muscles shaping the buttocks, e.g. tensor fasciae latae muscle or at least one of gluteal muscles: maximus, medius or minimus. In one preferred application all three gluteal muscles may be treated. Further other muscles may be treated, e.g. abdominal muscles, spinal muscles and/or thoracic muscles. By the complex treatment and muscle contraction in the body region the treated muscles may be strengthened, toned, the cellulite may be reduced and dimples may be removed. Buttocks and even the patient's figure may be enhanced in visual shape appearance and may become more attractive. Buttocks become well-shaped, round, firm, well-trained, toned, smoother, tight and lifted. The complex treatment may reduce hips, make perfect round and lifted buttocks, increasing the self-confidence of the patient.
The treatment may be more efficient than standard workout in fitness since the fitness machines strengthen only the isolated muscles. The results may be achieved in very short-time periods with minimal time of treatment. Without being limited, it is believed that the exercising of the gluteus medius may reduce the volume of the buttocks; exercising of the gluteus maximus may shape and/or lift the buttocks; exercising of the gluteus minimus may lift the buttocks.
The magnetic treatment may also treat at least one surrounding body region, e.g. thighs and/or saddlebags.
In the preferred application the magnetic treatment may be combined with other treatment methods using different approaches, e.g. conventional non-invasive treatments. The combined treatment may be applied to the surroundings tissues around buttocks to reduce the cellulite around the buttocks and enhance the shape of the enhanced appearance of the buttocks. The surrounding tissues may be represented by e.g. abdomen, love handles, thighs or saddle bags.
The magnetic field may treat at least one muscle responsible for silhouette of the body. The time-varying magnetic field may induce at least partial muscle contraction in different muscle and/or muscle group responsible for silhouette in the region of abdomen, love handles and/or bra fat. Following the position and/or orientation of the magnetic field generating device rectus abdominis muscle may be treated. Alternatively latissimus dorsi muscle, abdominal internal oblique muscle, abdominal external oblique muscle, transverse abdominal muscle and/or pyramidalis muscle may be treated by the time-varying magnetic field.
The treatment may cause circumferential reduction in the region of belly, hips and/or love handles. Alternatively the treatment may tighten at least one of these body parts. Further the muscles may obtain enhanced visual appearance, belly may be well-shaped. Repetitive application may even reach in a six-pack look. The at least one surrounding body region may be treated as well, e.g. buttocks.
The magnetic field may treat at least one muscle of upper limb, particularly the parts which may be prone to cellulite such as arm. The time-varying magnetic field may induce at least partial muscle contraction. Following the position and/or orientation of the magnetic field generating device the at least partial muscle contraction may occur in biceps brachii muscle, brachialis muscle, coracobrachialis muscle and/or triceps brachii muscle.
The treatment may cause circumferential reduction of the arm. Further the muscle may obtain enhanced visual appearance, arm may be well-shaped. Arm contour may be enhanced as well.
The at least partial muscle contraction may be more efficient for adipose tissue metabolism as the value of magnetic flux density increases since the muscle contraction may be stronger. The higher magnetic flux density may treat the higher number of muscle fibers contraction and the more adipose tissue may be reduced. Therefore the visual appearance of regions prone to cellulite may be enhanced.
Treatment by time-varying magnetic field may induce lipolysis. Adipose tissue may be reduced by decreasing the number and/or volume of adipose cells. Promoted adipose cell metabolism may increase as the value of magnetic flux density increases. The treatment may release free fatty acids (FFA) from at least one adipose cell. The increased concentration of FFA may influence a homeostasis of the adipose cell. A disruption of the homeostasis may cause a dysfunction of the adipose cell. The dysfunction may be followed by stress for endoplasmic reticulum (ER stress). ER stress may cause additional lipolysis and/or apoptosis of the at least one adipose cell.
Furthermore, ER stress may cause increase of intracellular calcium ions (Ca2+) which may promote an apoptotic process and may continue into controlled cell death of the adipose cell. The apoptosis may be induced by Ca-dependent effectors, e.g. calpain or caspase-12. Endogenous ligands or pharmacological agents, such as vitamin D, may induce prolonged cytosolic calcium increase. Vitamin D may influence release of Ca2+ from endoplasmic reticulum. Hence the effect of treatment may be enhanced by application of vitamin D and/or Ca2+ prior, during and/or after the treatment. The most significant effect may be achieved by application of both, Ca2+ and vitamin D, prior the treatment to provide all factors influencing adipose cell apoptosis.
Alternatively, increased level of Ca2+ may induce autophagy within adipose cell as well. Autophagy is self-eating process of cellular organelles to produce energy and it may proceed into cell death. Autophagy may be induced by ER stress or it may be induced via Ca2+ signaling.
The effect of the treatment by magnetic field for adipose tissue reduction may be influenced by various biological processes and/or pathways as recited above. The processes and/or pathways may be synergic hence the adipose tissue reduction may be accelerated and/or more efficient.
The method may cause the circumferential reduction i.e. a reduction of the size of the treated body region. The method may be mostly indicated for the regions with cellulite, particularly for thighs, buttocks, saddlebags, love handles, abdomen, hips and/or arms. However, the indication is not limited to the mentioned regions and the method may be used for treatment of any other body region.
Furthermore, the method may change BMI index of the patient. In a preferred application the BMI of the patient may be reduced. Alternatively, the BMI of the patient may increase.
Heating/Cooling
The magnetic field may be combined with application of heat and/or cold. The body region may be heated/cooled. The target biological structures may be selectively treated due to different tolerance of various biological structures to heating/cooling. Applying of heat/cold may improve metabolism of the biological structure, alternatively a reduction of the biological structure may occur.
Various biological structures have a different tolerance to heating/cooling. Hence target biological structures may be remodeled, e.g. adipose cells may be selectively reduced. The cells different from adipose cells such as epidermal cells, are not reduced by the heating/cooling. The selective reduction of adipose cell may be caused by e.g. crystallization within adipose cells. The heating/cooling of the adipose cell may reduce the number and/or volume of adipose cells by lipolysis, apoptosis and/or necrosis.
Cooling
Although the following exemplary treatment describes applying cold to the patient, the treatment method is not limited to the exemplary application. The method may include heating the patient instead of cooling the patient.
The cooling may be provided in a contact, indirect contact and/or non-contact manner. Contact cooling may be provided by a cooling element placed to the proximity of the treated body region, e.g. a thermally conductive material such as metal, gel or ice may be used. Indirect contact may be provided by a flow of cooling media within a layer of flexible and/or rigid material, e.g. cooling media such as glycerol, saline or water solution may be used. The cooling element may include a plurality of passages which the cooling media may flow in. Non-contact cooling may be provided by radiant cooling. Alternatively cooling media may be applied directly on the body region. The cooling media used for non-contact heating/cooling may be preferably a fluid, e.g. a gas or liquid. The gas may be applied in form of a spray, e.g. cold air, CO2 or N2 may be used. The cooling media may be at a predetermined temperature which may be controlled by the device to induce selective treatment of the target biological structure.
In an exemplary application the adipose cells may be selectively treated by cooling. A cooling media may be applied to the body region. A reduction of adipose cell may be induced by cooling the adipose cell. The cells different from adipose cells are not reduced by the cooling.
Temperature Ranges
The temperature of the cooling media and/or element may be less than the temperature of the patient's body. The temperature of cooling media may be at least −196° C. The temperature of the cooling element may be preferably in the range of 40 to −40° C., more preferably in the range of 20 to −20° C., even more preferably in the range of 10 to −15° C. or in the range of 5 to −10° C. A temperature of the adipose cells may be above a freezing point of water to prevent a reduction of cells including water. The temperature of the adipose cells may be preferably in the range of 37 to −10° C., more preferably in the range of 20 to −4° C., even more preferably in the range of 15 to −2° C. or around 4° C. The temperature of epidermis may be at least −40, −20, −10, 15, 20, 35° C., more preferably the temperature of epidermis may be in the range of around 5 to −5° C. The term around may be interpreted to mean in the range of 10% of the particular value.
Alternatively the body may be heated by application of various treatment methods, e.g. radiofrequency, diathermy or optical waves. The temperature in the target tissue may be up to 80° C., more preferably in the range of 37 to 60° C., even more preferably in the range of 39 to 50° C., most preferably in the range of 42 to 47° C. The temperature may be adjusted based on the intended use, e.g. adipose tissue reduction or collagen production.
The temperature of adipose cells may vary during the treatment. The temperature of the adipose cells may oscillate around a predetermined temperature. The temperature of the adipose cells may also follow a temperature profile in a predefined temperature range. The temperature and/or the temperature range may be adjusted following the patient's needs.
Cycles
Alternatively the adipose cells may be heated prior, during and/or after cooling. The term “heat prior” refers to preheating the adipose cells before cooling treatment. The term “heat during” refers to cyclically changing periods of cooling and heating the adipose cells during the treatment. The treatment may also include passive periods between heating and/or cooling. The term “passive period” refers to applying neither heating nor cooling. The term “heat after” refers to applying heat after the cooling treatment. The periods of heating/cooling and/or passive periods may be adjusted following by the patient's need.
Treatment Duration
The cooling may be applied for at least 10 seconds. Time duration of cooling the body region may be in the range of 1 to 240 minutes, more preferably in the range of 5 to 120 minutes, even more preferably 10 to 60 minutes, most preferably up to 30 minutes.
The cooling element and/or media may be applied continuously and/or in pulses. Continuous application may be used for a cooling element and/or media at a temperature above 0° C. Pulsed mode may be used for application of fluids below 0° C. The cooling may be provided cyclically for short periods in order of milliseconds, e.g. N2 may be applied cyclically to prevent damage to epidermis/dermis. The cooling element and/or media may be applied preferably non-invasively, e.g. by topical application. Alternatively the cooling element and/or media may be applied subcutaneously, e.g. injected.
Adjustable Applicator
The cooling element may correspond with the body region. The cooling element may be adjustable in shape to fit the body region. The cooling element may be made of flexible material to be modified in shape to follow the shape and/or contour of the body region. A fitting of the cooling element may provide homogenous treatment and/or temperature distribution. Further the heat exchange may be optimized at the contacted surface.
Pressure
A treatment may induce a thermal gradient in the body region, i.e. the shallow layer of the skin such as epidermis and/or dermis may have a lower temperature than the deeper layer such as adipose tissue. The effect of cooling may be improved by limiting and/or eliminating dermal blood flow. The dermal blood flow may be limited by applying vasoconstrictive medicine, preferably topically administered.
Positive
The dermal blood flow may also be limited and/or eliminated by applying a pressure. The pressure greater than systolic blood pressure may be used for pushing the blood out of the dermal and/or subcutaneous veins. The deeper adipose cells may be cooled and/or the cooling of the adipose cells to the temperature sufficient to reducing the adipose cells may be reached in shorter time period. Furthermore appropriate contact of the cooling element may be provided by the pressure in case of contact treatment.
Negative
The treatment effect may also be enhanced by applying negative pressure to the skin below the applicator, e.g. a convex cooling element may be used. The skin may be pulled towards the inner surface of the cooling element. Hence the contact may be enabled by applying negative pressure. Alternatively, the folded tissue may be pinched by two or more cooling elements and the cooling may be applied to the tissue, particularly to adipose cells. Further the skin may be stretched and a thickness of the skin may decrease. Skin thickness decrease may promote improved heat transfer to/from adipose cells.
Miscellaneous
The cooling may be applied with application mechanical treatment such as acoustic, ultrasound, and/or shockwave treatment to enable more homogenous treatment effect. The adipose cells reduction may also be promoted by physical movement of the body region by e.g. massaging, or vibrations. The pressure applied to the body region may vary to improve the results.
Protocols
An apoptotic index may increase after cooling the body region. The apoptotic index refers to a percentage of apoptotic cells in specimen. The apoptotic index may increase due to cooling up to ten times greater value compared with the value prior the cooling.
Based on the apoptotic index a treatment combining various methods may be designed as a tailor-made solution following the patient's need. The cooling may be applied to the body region of the patient prior, during and/or after applying a magnetic field to the patient.
Pain Relief
A pain relieving medicament may be provided during the treatment if the patient is more sensitive to decreased temperature. A topical application may be preferred. The pain relief effect may be provided by a magnetic field of repetition rate at least 100 Hz, more preferably 120 Hz, even more preferably at least 140 Hz or at least 180 Hz. The pain relieving effect may be provided before, during or after the treatment.
Precooling
Cooling the body region prior to applying the magnetic field may influence a metabolism of adipose cells. Alternatively, the cooling of the adipose cells may induce apoptosis, lipolysis, autophagy and/or disruption of the adipose cells. A release of FFA from adipose cells may induce ER stress as recited above. The application of the magnetic field may cause at least partial muscle contraction reducing the adipose cells. Furthermore the released FFA from adipose cells influenced by cooling may be used as energy source for muscle work. Hence the cooling may be followed by treating a patient by magnetic field inducing at least partial muscle contraction. Due to the combined effect of cooling and magnetic treatment the adipose cells may be reduced in number and/or volume. Moreover the muscles may be shaped, tightened, strengthened and/or the volume of the muscle may increase. Additionally, the cellulite appearance may be reduced due to muscle work.
The magnetic treatment may provide a massage effect. Hence blood and/or lymph flow may be improved. Additionally frozen tissue may be relaxed.
The combined magnetic treatment may be applied immediately after cooling, more preferably around 1 to 24 hours after cooling, e.g. 1, 2, 8 or 20 hours after cooling. The combined treatment may be applied periodically. Alternatively, the treatment by cooling and/or magnetic field may be applied separately, e.g. treatments may alternate in appropriate periods. The period may last from 12 hours to 1 month, more preferably from 1 day to 2 weeks, most preferably from 3 days to 1 week.
In an exemplary application of the treatment method a patient's body region may be cooled by a cooling element for e.g. at least 20 minutes up to 1 hour. After stopping the cooling the body region may be treated by magnetic field for e.g. 15 to 45 minutes.
Cooling
Cooling the body region may be applied simultaneously while the body region is treated by magnetic field within one treatment.
The magnetic cooling may be provided to the patient while the patient is being treated by magnetic field.
Alternatively, cooling may alternate with treatment by magnetic field, i.e. the magnetic field is applied when cooling is not provided to the patient or vice versa. Periods of alternating cooling and magnetic treatment may vary.
The magnetic field may be preferably applied in burst mode. Each burst contains train of magnetic impulses and a period of no magnetic treatment. The train may include a plurality of magnetic impulses. A number of magnetic impulses may vary in the range of at least 1 to 10000 impulses, more preferably in the range of at least 10 to 1000 impulses. The time duration of the train and/or the period of no magnetic treatment may vary in order of milliseconds to order of seconds, e.g. in the range of 100 milliseconds to 100 seconds, more preferably in the range of 1 to 30 seconds, most preferably in the range of 5 to 15 seconds.
An essential principle of magnet therapy used for biological structure stimulation is the influence of the magnetic field on the cell. The cell membrane is polarized due to the induced electric current. One of fundamental phenomenon of electric current in biological tissue may be an action potential occurrence, a transfer of neural excitation and/or a partial or full muscle contraction may be induced. Additionally, the effect of the generated action potential may modulate a painful stimulus transmission, providing a pain management effect.
According to still another application of the invention, the neural structure stimulation by time-varying magnetic field may be used for pain management.
According to one approach of the aspect of the application in pain management, the neural structure may be stimulated by an envelope created by higher repetition values e.g. exceeding 100 Hz, more preferably at least 150 Hz, even more preferably at least 200 Hz, most preferably at least 250 Hz, or up to 700 Hz. The envelope may be generated with predefined repetition frequency and/or shape.
According to still another approach of the aspect of the application in pain management, the neural structure may be stimulated by trains 1501 of several pulses 1502 and time with no stimulation after the train 1501. The group of several pulses 1502 and the time with no stimulation is called burst 1504. Therefore one burst 1504 consists of the only one train 1501 and time with no stimulation 1503. The train 1501 preferably consists of at least 2 pulses, more preferably 5 pulses, even more preferably tens pulses or up to hundreds pulses; repetition rate of the pulses 1502 is at least 100 Hz. The burst repetition rate may vary following the patient's needs. In the preferred application the burst repetition rate vary from 1 to 10 Hz. The number of pulses 1502 in train 1501 and/or the time with no stimulation may vary following the patient needs.
In an alternative application the neural structure may be stimulated by rectangular or increasing shaped envelope as well.
According to another aspect of the application in neural system diagnostics, the neural structure may be stimulated by single pulses or rectangular shaped envelope, and by increasing shaped envelope. Both envelopes are used for determination of minimal magnetic flux density value sufficient to induce at least partial muscle contraction. The envelope duration may last 1 second. After the determination of both magnetic flux densities values, the level of muscle denervation may be calculated.
According to still another aspect of the invention, the magnetic treatment may be used for treatment of diabetes, e.g. function of pancreas and/or liver may be improved. The magnetic field may influence hyperglycemia. Hence the treatment may reduce diabetic neuropathy which is caused by hyperglycemia.
Furthermore, the magnetic treatment may relieve the consequences of the neuropathy by locally improved blood, perfusion, metabolism or lymph circulation. The progress of the neuropathy may be inhibited, e.g. foot infection may be treated and/or reduced hence amputation may be prevented. Moreover, the magnetic treatment may be used for inducing pain relieving effect. The diabetes may be associated with venous ulcers which may be treated by magnetic treatment as well. The treatment of venous ulcer may be treated by similar effects as the consequences of the neuropathy.
In one exemplary application the body region may be cooled for a period of e.g. at least 5 minutes. After stopping the cooling the body region may be treated by a magnetic field for a period of e.g. at least 5 minutes. After stopping the magnetic treatment the body region may be cooled.
Post Cooling
The cooling may also be applied after magnetic treatment. The treatment by magnetic field may provide stimulation, pain relief and/or a myorelaxation effect for the treated body area before cooling. The cooling applied with pressure may be better accepted by the adipose tissue when the muscle below the adipose cells is relaxed. Alternatively the magnetic treatment may provide a temporary pain relief effect hence a patient suffering from a lower pain threshold, e.g. cool sensitivity, may be treated.
In an exemplary application the body region may be treated by a magnetic field for a period of e.g. at least 15, 20 or 30 minutes. After stopping the magnetic treatment the body region may be cooled.
The cooling may be applied immediately after magnetic treatment, more preferably around 1 to 24 hours after magnetic treatment, e.g. 1, 2, 8 or 20 hours after magnetic treatment. The combined treatment may be applied periodically.
In an exemplary application of the treatment method a patient's body region may be treated by magnetic field for e.g. at least 20 minutes up to 1 hour. After stopping the magnetic treatment the body region may be treated by cooling for e.g. 15 to 45 minutes.
In the previously described exemplary treatment methods the cooling of the patient may be replaced by heating the patient.
All the recited combined treatment methods may be provided by at least one applicator. The applicator may provide cooling and magnetic treatment. Alternatively one applicator may provide cooling and second applicator may provide magnetic treatment.
Combined Magnetic and Radiofrequency
The target structure may be treated by combined methods which may be used for remodeling the adipose tissue, body shaping and/or contouring, muscle toning, skin tightening, skin rejuvenation, wrinkle removing, reducing stretchmarks, breast lifting, lip enhancement or treatment of cellulite in general by application of electromagnetic radiation to target structure to selectively heat the target tissue to remove and/or remodel adipose tissue from the target tissue. The second approach is to transmit a magnetic treatment to the target structure, inducing at least partial muscle contraction within the target structure to remodel the adipose tissue by natural adipose tissue catabolism. Adipose tissue catabolism may be caused by apoptosis or necrosis of the adipocytes. The muscle contraction caused by induced eddy current is the same as a natural contraction. The adipose tissue may be reduced in natural way. Additionally, the muscle may be shredded in a natural way. Therefore the effect resulting in body shaping and/or contouring may be significantly improved.
The combination of the recited method may improve currently used applications in various aspects and the effect of the treatments may be significantly enhanced. The application of a radiofrequency electromagnetic field may be combined with application of a magnetic field applied before, simultaneously or after the radiofrequency treatment. The application of a magnetic field may induce many benefits for radiofrequency treatment, such as applications inducing at least partial muscle contraction, myorelaxation effect or analgesic effect. The perfusion or metabolism may be improved as well.
The at least partial muscle contraction may induce enhanced effects on adipose tissue reduction by catabolism of the adipose tissue and burning energy from adipose tissue. The total adipose tissue reduction effect may be enhanced by radiofrequency treatment.
Additionally, the at least partial muscle contraction may improve a blood flow and/or perfusion in the treated body region. The improved blood flow may be caused by activation of muscle pump and/or by the muscle necessity of more oxygen due to the at least partial contraction. The blood flow may increase rapidly and it may last temporarily, preferably up to 1 hour, more preferably up to 45 minutes, most preferably up to 30 minutes. Due to increased blood flow and/or local perfusion, the risk of overheated muscle may be limited or even eliminated. Further the homogeneity of the thermal field induced by thermal effect of radiofrequency treatment may be significantly enhanced and/or the temperatures may be well-balanced/compensated in the target body region. Still another benefit may be prevention of creation any hot spot caused by steep thermal gradient.
Due to improved blood flow, perfusion and/or lymph flow the metabolism may be improved. Additionally, the effect of radiofrequency treatment may be enhanced by improved metabolism, e.g. cellulite treatment, body shaping and/or contouring, skin tightening or skin rejuvenation. Further benefit may be reducing or eliminating the risk of panniculitis or local skin inflammation since any clustering of the treated adipocytes may be prevented by the improved metabolism. The improved blood and/or lymph flow may contribute the removing of the adipocytes. The removing of the adipocytes may be promoted by higher number of cells phagocytosing the adipocytes as well. Synergic effects of magnetic and RF treatment may significantly improve metabolism. Therefore the possibility of adverse event occurrence may be limited and treatment results induced by the present invention may be reached in shorter time period.
Further the at least partial muscle contraction may improve the movement of lymphatic vessel and the lymph flow may be improved.
In the preferred application the RF and/or magnetic field may be modulated. In the most preferred application both treatments are modulated. The magnetic treatment may be modulated in the magnetic flux density domain, repetition rate domain, or impulse duration domain, to provide different treatment effects and to prevent adaptation of the target biological structure. The radiofrequency treatment may be modulated in the frequency domain, intensity domain and/or time domain to reach the most complexity and/or efficiency of the target treated biological structure. The modulation in the time domain may be changing the active and passive periods of stimulation, e.g. the radiofrequency treatment may include period with no stimulation, i.e. the radiofrequency treatment may be not continual but the treatment may be provided in pulses. The periods of no stimulation may vary and may be adjusted by the operator. Due to modulation during the treatment, different target biological structures may be treated in the different depth.
The application may be contact or in the preferred application the treatment may be applied contactless. Contactless application may avoid all biocompatibility factors which may occur during contact treatment. In the most preferred application the treatment may be provided by self-operated device. Hence the applicator and/or magnetic field generating device need not be guided by the operator. The applicator may be fixed at a sufficient distance from the patient's skin enabling safe treatment for the patient. Self-operated treatment may be provided by a hand-held applicator or the applicator may be fixed to stand-alone device. The self-operated treatment may be also enabled using various types of sensors in communication with the device for monitoring the treatment and/or the patient. The at least one sensor may be e.g. reactive sensor, electrochemical sensor, biosensor, biochemical sensor, temperature sensor, sorption sensor, pH sensor, voltage sensor, sensor for measuring distance of applicator from the patient surface and/or from the treated area, position sensor, motion detector, photo sensor, camera, sound detector, current sensor, sensor for measuring of specific human/animal tissue and/or any suitable sensors measuring biological parameters and/or combination thereof such as sensor for measuring dermal tensile forces, sensor for measuring the activity of the muscle, muscle contraction forces, tissue impedance or skin elasticity.
Further the homogeneity of the treatment may be improved by several approaches. A first approach may be represented by a moveable applicator providing the dynamic treatment to a large target area. The dynamic treatment may improve the homogeneity of applied treatment energy and additionally due to large area the effect is uniform and/or well balanced. Static positioning of the applicator may be used as well. Another approach of improving homogeneity may be represented by using a bolus. The bolus may provide improved transmittance of the electromagnetic energy to the treated biological structures. Additionally, the bolus may prevent occurrence of hot spots within the treated area; the bolus may provide constant temperature to the target treated surface area; or the bolus may increase the homogeneity of the radiofrequency waves application by providing a homogenous medium for electromagnetic waves propagation not being influenced by the interface of the target treated area and an air. The bolus may profile the electromagnetic field to enhance the effect of the treatment. In still another approach an air gap may be between the applicator and the patient.
The treatment by magnetic and/or electromagnetic field may be in continuous or discrete mode. In one application the magnetic treatment may be applied in continual mode with no pauses and the electromagnetic treatment may be applied in pulsed mode to provide improved adipose tissue reduction caused by natural process and by the increased temperature. In another application the electromagnetic treatment may be applied continuously with no pauses and the magnetic treatment may be applied in pulsed mode to provide improved thermal reduction of adipose tissue and by improved metabolism due to improved blood flow. Both modes may be combined in various treatment sequences.
In the preferred application the treatment may be started at the moment when the target biological structure reaches the predetermined temperature. The temperature in the target tissue may be up to 80° C., more preferably in the range of 37 to 60° C., even more preferably in the range of 40 to 45° C. The temperature may be adjusted based on the intended use, e.g. adipose tissue reduction, collagen production or muscle contraction. In an alternative application the intended use may be coagulation and/or ablation. The temperature in the target biological structure may be measured by invasive method, e.g. using an invasive probe; or by contact method, e.g. using thermocouple sensor; or by contactless method, e.g. using infrared sensor or camera. The temperature of the target biological structure may be determined by a mathematic method. The sensor for measuring the temperature in the target biological structure may be attached to the applicator.
The applicator may include at least one sensor for detecting the temperature of the skin. The sensor may be preferably contactless. Alternatively the sensor may measure the temperature in contact manner. Alternatively, the skin impedance may be determined as well.
A benefit of the application of magnetic treatment and electromagnetic treatment may be causing an analgesic effect of the application and providing a possibility of treating a patient with higher sensitivity for thermal effects induced by electromagnetic treatment, i.e. patients with any predisposition inducing increased thermal sensitivity. The analgesic effect may be induced by magnetic treatment by suitable repetition rates and it may be induced immediately during the magnetic treatment. The analgesic effect may last up to several hours after magnetic treatment. The magnetic flux density of the magnetic treatment may preferably reach at least motor-threshold intensity inducing at least partial muscle contraction therefore the homogeneity of the thermal field may be significantly enhanced.
Another benefit of application the magnetic treatment may be causing a myorelaxation effect. The magnetic treatment may be applied on spastic muscle structures to relieve the hypertonus of the muscle and improving the blood and/or lymph flow. Therefore relieving the hypertoned muscle may contribute to the analgesic effect and contribute to the acceptability of the treatment by the patient.
The blood and/or lymph flow may be limited in the spastic muscles and the metabolism may be limited as well, meaning that the risk of clustering the treated target structures may be higher and possible adverse events may occur. The recited risks may be eliminated by the used of magnetic treatment.
In one aspect of the invention, the treatment by magnetic field may be applied to the target structure before the radiofrequency treatment to prepare the target structure for following treatment by radiofrequency field. The effect of magnetic treatment may be to induce at least partial muscle contraction or to treat a muscle structure to increase a muscular tonus of the target structure. Both effects may provide a massage effect for the structure within the proximity of the target structure hence the blood and/or lymph circulation may be improved to promote local metabolism. The temperature may be locally increased by the improved blood flow and the target structure may accept the following radiofrequency treatment at significantly higher quality. Additionally, the collagen and/or elastin fibers may be remodeled or restored and/or its neogenesis may be improved to provide a younger, smoother, firmer and enhanced skin appearance.
Additionally, previous application may improve acceptability of the electromagnetic field by increasing the temperature of the skin and the transmittance of the electromagnetic field may be improved due to less value of skin impedance. Further the radiofrequency may penetrate deeper target structures relative to treatment without a preceding magnetic treatment of the target structure and/or area.
Another benefit may be releasing the adipose tissue in the muscle by muscle contraction and/or by temperature increase causing better liquidity of adipose tissue. Still another benefit of the at least partial muscle contraction may be mechanical breaking large adipose tissue bulks into smaller bulks which may be easier metabolized and/or the smaller adipose tissue bulks may be removed faster by the lymphatic and/or blood flow. Due to improved metabolism and/or circulation the cellulite may be treated in a short time and the visual effect on skin appearance may be significantly enhanced.
In another aspect of the invention, the treatment by magnetic field may be applied to the target structure simultaneously with the radiofrequency treatment to improve effects of the electromagnetic treatment inducing heat in the target structure.
The simultaneous application of magnetic treatment and radiofrequency treatment may be in two modes: a first mode may generate the magnetic impulses while radiofrequency treatment is active or another mode may generate radiofrequency treatment while the magnetic treatment is not in an active stimulation period, i.e. the period of magnetic treatment and radiofrequency treatment alternates. Both modes amplify the resulting effect of the treatment. Therefore the results may be achieved in significantly shorter time than the same results achieved by separate applications of the radio frequency and magnetic treatments.
The simultaneous method of magnetic treatment and radiofrequency treatment of the target tissue may increase the peak magnetic component of the entire treatment resulting in improved heating of the target structure including containing higher water volume, e.g. skin. Due to increased temperature of skin, the production and/or remodeling of collagen and/or elastin fibers may be improved and the skin may be provided with a younger, smoother, firmer and enhanced appearance. The effect of overheating the muscle may be reduced by the improved blood flow.
In still another aspect of the invention, the treatment by magnetic field may be applied to the target structure after the treatment by electromagnetic field to enhance and/or contribute to the effects of radiofrequency treatment by influencing the target structure by magnetic field.
The magnetic field may treat the target structure to cause at least partial muscle contraction proximate to the target structure to improve blood flow and provide homogenous temperature distribution at high quality after creating a temperature distribution at lower quality by radiofrequency treatment.
All of the methods may be provided by the above recited technical solutions. The above mentioned methods may be used separately or in any combination.
The method may cause the circumferential reduction i.e. a reduction of the size of the treated body region. The method may be mostly indicated for the regions with cellulite, especially for buttocks, saddlebags, love handles, abdomen, hips, thighs or arms. However, the indication is not limited to the mentioned regions and the method may be used for treatment of any other body region.
The at least one applicator may include at least one magnetic field generating device. The plurality of magnetic field generating devices may be positioned in isolated locations of the at least one applicator. Alternatively, the magnetic field generating devices may be positioned next to each other, in an array or matrix, in a pattern or in randomized locations of the at least applicator.
The magnetic field generating devices may be positioned and/or moved in the at least one applicator in one plane; in at least two mutually tilted planes defined by a convex or concave angle, or perpendicular to each other; or in at least two parallel planes with the at least one magnetic field generating device in each parallel plane. The movement of the at least one magnetic field generating device may be translational and/or rotational, constant or accelerated. The movement may follow a predetermined, random or predefined trajectory, such as a pattern, array or matrix. The movement of the at least one applicator may be handled in similar manner as the movement of the at least one magnetic field generating device. The angles of the planes and/or the movement of the at least one magnetic field generating device may be adjusted by an operator following the patient's needs. The positioning may be provided by mechanical holder, enabling tilting, distancing and positioning magnetic field generating device in various planes. In an alternative embodiment the patient may be positioned in the intersection of the magnetic fields generated by the plurality of magnetic field generating devices. In the preferred application the at least one applicator may be movable and the movement may be circular.
The plurality of magnetic field generating devices may be positioned within one applicator having form of mechanical holder. The shape of the applicator having form of mechanical holder may be adjustable, e.g. the applicator may include at least one moveable part. In a preferred embodiment the applicator having form of mechanical holder may provide spatial arrangement of the energy delivery elements in one axis, two axes or three axes and/or provide tilting and/or rotation. The applicator having form of mechanical holder may provide fixation of the at least one magnetic field generating device in one position. The moveable parts may be connected by sliding mechanism and/or by a joint mechanism. An exemplary embodiment of such an applicator may be found in U.S. Pat. No. 9,468,774, incorporated herein by reference. The applicator may be adjustable following the body region and/or biological structure.
The static position of the at least one applicator may be provided by a positioning member. The positioning member may be e.g. an arm or an adjustable flexible belt. The positioning member may include a buckle for adjusting the length of the belt. The applicator may be placed within predefined locations of the belt. Alternatively the applicator may be shaped to be moveable along the positioning member, e.g. the shape of the applicator may be preferably concave, e.g. V-shaped or U-shaped. The positioning member may be inserted itself into the concavity of the applicator. The position of the applicator may be adjusted by limited movement along the positioning member because the positioning member may be used as guiding member. However, the applicator may not be fixed to a particular static position. The position of the applicator may be dynamically adjusted during the treatment following the patient's needs. The position of the applicator may be adjusted manually by the operator, or automatically by the treatment device. In one exemplary embodiment a plurality of applicators may be used for treating larger body regions, e.g. buttocks, abdomen or thigh.
The present methods may also induce muscle contraction to reduce effect of skin laxity. Skin laxity may be caused by e.g. aging process or increasing number and/or volume of adipose cells which pulls down the skin by gravity, rapid weight loss or skin stretching during the pregnancy. The muscles may be treated by the induced electric current to contract. Repetitive contractions may cause the muscles to obtain the tonus and flexibility. Therefore the skin appearance may be enhanced by treating the flabby muscles. The effect of skin tightening may be achieved. The method also may promote the collagen and elastin fibers in the layers subtending the epidermis hence the skin may obtain enhanced visual appearance. The method may be widely applied but not limited to application to the regions of neck, breasts, arms or abdomen. The method may provide the smoother and younger appearance of the skin to the patient.
Similar methods of the muscle structure treatment by time-varying magnetic field for inducing the at least partial muscle contraction may be used for treatment of wrinkles as well. Wrinkles are results of extrinsic and intrinsic factors. Nowadays, wrinkles are considered to be negative effect of natural aging process which decreases the production of collagen and elastin fibers and weakens the skin which becomes thinner. As the muscle treatment by the magnetic flux density may induce at least partial muscle contraction, the collagen and elastin fibers neogenesis may be improved. Additionally, the muscles subtending the treated region may be toned and the skin may obtain a younger and enhanced visual appearance. Therefore, the effect of skin tightening may be achieved.
Wrinkles may be prevented or reduced by practicing facial exercises which may cause a massage effect to the facial tissues, improving blood and lymph circulation. Additionally, the facial muscles may be relaxed and toned after the exercise. A similar effect as facial exercise may be achieved by non-invasive and/or contactless method of treating the facial muscles by magnetic flux density. Further additional advantage of the present method may be the improvement of restoration of the collagen and elastin fibers, more effective toning and strengthening of the facial muscles.
The present methods may improve the neogenesis and remodeling of collagen fibers in the lips to reach a full, plump and firmer appearance. The magnetic flux density may be applied to the lips by an applicator. Therefore the lips may become fuller and firmer without any need of invasive method such as injection of the synthetic fillers, permanent makeup or the facial implants. The present method may promote the remodeling and/or neogenesis of collagen fibers in a natural way. Additionally, the collagen is natural substance of the human body which may provide the elasticity to the structure.
The present methods may be used for enhancing the visual appearance of breasts. Cooper's ligament may be treated, improved and/or firmed by the at least partial muscle contraction. The treatment may induce the elevation of the breast tissue. Additionally, the breast tissue may be treated to be modified in a shape, wherein the shape includes the size and/or the contour of the breast tissue. Therefore the visual appearance may be enhanced and breasts may be more attractive for the patient. The present method may be a non-invasive alternative for current aesthetic surgery method for the treatment of sagging breast tissue. The present method may provide a patient a method of breast visual appearance enhancement without surgery. Therefore the method lacks post-surgery complications such as scars, postoperative pain or long recovery period. Various treatment protocols may be used.
Following the recited methods the treatment may be but is not limited to continuous, pulsed, randomized or burst. The impulse may be but not limited to monophasic, polyphasic, biphasic and/or static magnetic field. In the preferred application the magnetic impulse may be in biphasic regime, i.e. it is consisted of two phases, preferably positive and negative.
In the preferred application of the present method the trains of pulses, called bursts are used.
Repetition rate and/or magnetic flux density may vary during the treatment protocol. Further the treatment may include several periods of different repetition rates, therefore the modulation may be in repetition rate domain. The treatment may include several periods of different magnetic flux densities, therefore the modulation may be in magnetic flux density domain. Alternatively the treatment may include different impulse durations, therefore the modulation may be in impulse duration domain. In yet another approach the treatment may be modulated by any combinations thereof.
Various envelopes and/or waveforms, e.g. pulse, sinusoidal, rectangular, square, triangular, saw-tooth, trapezoidal, exponential etc. for the purpose of muscle treatment may also be used, and are not limited to recited shapes.
The values of magnetic flux density and repetition rate are cited in several preferred applications since the perception of the treatment is subjective. Nevertheless, the magnetic flux density and repetition rates are not limited by the recited values. A person skilled in the physical therapy is able to repeat and apply the treatment methods adjusting the magnetic flux density and/or repetition rate following the patient's sensitivity or needs.
The present method is not limited to be used independently. For enhancing the result the method may be used in combination with other conventional non-invasive and/or invasive aesthetic treatment method.
All the recited methods may be applied to a patient in a non-invasive and/or contactless way. Therefore the present methods provide an effective alternative approach of enhancing the visual appearance with no need of invasive treatment or surgery. Further, the visual results are appreciable after several treatments. Additionally, the results include not only the visual appearance enhancement but even the improvement of the muscle structures, hence the patient feels firmer and tighter. The muscle structures become toned with no need of any diet or spending time by exercising in fitness.
The patient may feel firmer and/or tighter. The skin may be also tighter. Additionally, adipose tissue reduction may occur. Furthermore, cellulite may be reduced as well.
A method of treating a biological structure uses a combination of non-invasive methods for enhancing human appearance. The invention utilizes electromagnetic radiation. Methods may be used for targeted remodeling adipose tissue, focused treatment of cellulite, body contouring, skin tightening or skin rejuvenation. The invention relates to focused heating of the target tissue by electromagnetic waves, whereas the effect of focused heating of the target tissue is amplified by the effect of a pulsed magnetic field treatment.
The present invention discloses the advanced approaches in aesthetic applications, e.g. for cellulite treatment and/or body shaping. Combined methods of treatment by electromagnetic field and treatment by magnetic field are used. The electromagnetic field may include treatment by radiofrequency, infrared or optical waves. The magnet treatment may be provided by permanent magnets, electromagnetic devices generating a static magnetic field or time-varying magnetic devices. In the preferred application the treatment by a pulsed magnetic field and radiofrequency treatment may be combined. However the application is not limited by the recited combination so the combined method may include magnet treatment and any treatment by electromagnetic field, e.g. light treatment, IR treatment or treatment by radiofrequency waves, e.g. microwaves, short waves or long waves.
Magnet treatment in combination with radiofrequency treatment may be represented by two independent treatment devices, e.g. one treating the target structure by radiofrequency waves and the second treating the target structure by magnetic field. Both devices may have a separate applicator for treating the target structure, or one applicator may be used by at least two devices, i.e. the applicator may be modular for a plurality of devices.
The aesthetic treatment device may include at least one HF frequency generator for providing energy for radiofrequency treatment and for providing energy for magnet treatment. In an alternative embodiment, the device may include at least one HF frequency generator for providing energy for radiofrequency treatment and at least one other independent frequency generator for providing energy for magnet treatment. The device may include plurality of applicators for providing separate radiofrequency or magnet treatments to the patient.
In alternative embodiment the applicator may provide a combination of radiofrequency and magnet treatment. In one embodiment, the applicator may include at least one radiofrequency electrode for providing radiofrequency treatment and at least one coil for providing magnet treatment. In another embodiment, the applicator may include at least one electrode for providing radiofrequency treatment and at least one coil providing magnet treatment, wherein the at least one RF source provides energy for both at least one electrode and at least one coil.
In still another embodiment the at least one RF source may provide the energy for the at least one coil providing magnet treatment wherein the at least one coil may be used as the at least one electrode. The essence is the far different stimulation frequencies which are used for RF treatment and magnet treatment. The coil in the high frequency field is similar to the electrode. This enables the coil to be the electrode for radiofrequency treatment. In the preferred embodiment a flat coil may be used as the electrode.
The frequencies for the radiofrequency treatment may be in the range of ones of MHz to hundreds of GHz, more preferably in the range of 13 MHz to 3 GHz, most preferably around 13.56 or 40.68 or 27.12 MHz or 2.45 GHz. The term “around” should be interpreted as in the range of 5% of the recited value.
The combination of the recited method may improve currently used applications in various aspects and the effect of the treatments may be significantly enhanced. The application of a radiofrequency electromagnetic field is combined with application of a magnetic field applied before, simultaneously or after the radiofrequency treatment. The magnetic field may be generated by a permanent magnet or electromagnet. The magnetic field may be constant in time or in the preferred application the magnetic field may be time-varying, more preferably a pulsed magnetic field may be used. The application of a magnetic field induces many benefits for radiofrequency treatment, such as applications inducing at least partial muscle contraction, myorelaxation effect or analgesic effect. The perfusion or metabolism may be improved as well.
The at least partial muscle contraction may induce enhanced effects on adipose tissue reduction by catabolism of the adipose tissue and burning energy from adipose tissue. The total adipose tissue reduction effect is enhanced by radiofrequency treatment.
Additionally, the at least partial muscle contraction may improve a blood flow and/or perfusion in the treated area. The improved blood flow may be caused by activation of muscle pump and/or by the muscle necessity of more oxygen due to the at least partial contraction. Due to increased blood flow and/or local perfusion, the risk of overheated muscle is limited or even eliminated. Further the homogeneity of the thermal field induced by thermal effect of radiofrequency treatment may be significantly enhanced and/or the temperatures may be well-balanced/compensated in the target treatment area. Still another benefit is prevention of creation any hot spot caused by steep thermal gradient.
Further the at least partial muscle contraction may improve the movement of lymphatic vessel and the lymph flow may be improved.
Due to improved blood flow, perfusion and/or lymph flow the metabolism may be improved. Additionally, the effect of radiofrequency treatment may be enhanced by improved metabolism, e.g. cellulite treatment, body shaping and/or contouring, skin tightening or skin rejuvenation. Further benefit may be reducing or eliminating the risk of panniculitis or local skin inflammation since any clustering of the treated adipocytes may be prevented by the improved metabolism. The improved blood and/or lymph flow may contribute the removing of the adipocytes. The removing of the adipocytes may be promoted by higher number of cells phagocytosing the adipocytes as well. Synergic effects of magnet and RF treatment significantly improves metabolism. Therefore the possibility of adverse event occurrence is limited and treatment results induced by the present invention are reached in shorter time period.
In the preferred application the RF and/or magnetic field may be modulated. In the most preferred application both stimulation signals are modulated. The magnetic stimulation may be modulated in the magnetic flux density domain, repetition rate domain, or impulse duration domain, to provide different treatment effects and to prevent adaptation of the target biological structure. The radiofrequency treatment may be modulated in the frequency domain, intensity domain and/or time domain to reach the most complexity and/or efficiency of the target treated biological structure. The modulation in the time domain may be changing the active and passive periods of stimulation, e.g. the radiofrequency treatment may include period with no stimulation, i.e. the radiofrequency treatment is not continual but the treatment is provided in pulses. The periods of no stimulation may vary and may be adjusted by the operator. Due to modulation during the treatment, different target biological structures may be treated in the different depth.
The application may be contact or the preferred application of the invention the treatment may be applied contactless. Contactless application may avoid all biocompatibility factors which may occur during contact treatment. In the most preferred application the treatment may be provided by self-operated device. Hence the continual surveillance and/or control by the operator is not essential for correct and/or safe operation of the treatment device. Self-operated treatment may be provided by a hand-held applicator or the applicator may be fixed to stand-alone device. The self-operated treatment may be also enabled using various types of sensors in communication with the device for monitoring the treatment and/or the patient. The at least one sensor may be e.g. reactive sensor, electrochemical sensor, biosensor, biochemical sensor, temperature sensor, sorption sensor, pH sensor, voltage sensor, sensor for measuring distance of applicator from the patient surface and/or from the treated area, position sensor, motion detector, photo sensor, camera, sound detector, current sensor, sensor for measuring of specific human/animal tissue and/or any suitable sensors measuring biological parameters and/or combination thereof such as sensor for measuring dermal tensile forces, sensor for measuring the activity of the muscle, muscle contraction forces, tissue impedance or skin elasticity.
Further the homogeneity of the treatment may be improved by several approaches. A first approach may be represented by a moveable applicator providing the dynamic treatment to a larger target area. The dynamic treatment improves the homogeneity of applied treatment energy and additionally due to larger area the effect is uniform and/or well balanced. Static positioning of the applicator may be used as well. Another approach of improving homogeneity may be represented by using a bolus. The bolus may provide improved transmittance of the electromagnetic energy to the treated biological structures. Additionally, the bolus may prevent occurrence of hot spots within the treated area; the bolus may provide constant temperature to the target treated surface area; or the bolus may increase the homogeneity of the radiofrequency waves application by providing a homogenous medium for electromagnetic waves propagation not being influenced by the interface of the target treated area and an air. The bolus may profile the electromagnetic field to enhance the effect of the treatment. In still another approach an air gap may be between the applicator and the patient.
The treatment by magnetic and/or electromagnetic field may be in continuous or discrete modes. In one application the magnetic treatment may be applied in continual mode with no pauses and the electromagnetic treatment may be applied in pulsed mode to provide improved adipose tissue reduction caused by natural process and by the increased temperature. In another application the electromagnetic treatment may be applied continuously with no pauses and the magnetic treatment may be applied in pulsed mode to provide improved thermal reduction of adipose tissue and by improved metabolism due to improved blood flow. Both modes may be combined in various treatment sequences.
In the preferred application the treatment is started at the moment when the target biological structure reaches the predetermined temperature. The temperature in the target tissue may be up to 80° C., more preferably in the range of 37 to 60° C., even more preferably in the range of 40 to 45° C. The temperature may be adjusted based on the intended use, e.g. adipose tissue reduction, collagen production or muscle contraction. In an alternative application the intended use may be coagulation and/or ablation. The temperature in the target biological structure may be measured by invasive method, e.g. using an invasive probe; or by contact method, e.g. using thermocouple sensor; or by contactless method, e.g. using infrared sensor or camera. The temperature of the target biological structure may be determined by a mathematic method. The sensor for measuring the temperature in the target biological structure may be attached to the applicator.
A benefit of the application of magnet treatment and electromagnetic treatment may be causing an analgesic effect of the application and providing a possibility of treating a patient with higher sensitivity for thermal effects induced by electromagnetic treatment, i.e. patients with any predisposition inducing increased thermal sensitivity. The analgesic effect may be induced by magnet treatment by suitable repetition rates and it may be induced immediately during the magnet treatment. The analgesic effect may last up to several hours after magnet treatment. The magnetic flux density of the magnetic stimulation may preferably reach at least motor-threshold intensity inducing at least partial muscle contraction therefore the homogeneity of the thermal field is significantly enhanced.
In one aspect of the invention, the treatment by magnetic field may be applied to the target structure before the radiofrequency treatment to prepare the target structure for following treatment by radiofrequency field. The effect of magnet treatment is to induce at least partial muscle contraction or to stimulate a muscle structure to increase a muscular tonus of the target structure. Both effects may provide a massage effect for the structure within the proximity of the target structure hence the blood and/or lymph circulation may be improved to promote local metabolism. The temperature may be locally increased by the improved blood flow and the target structure may accept the following radiofrequency treatment at significantly higher quality. Additionally, the collagen and/or elastin fibers may be remodeled or restored and/or its neogenesis may be improved to provide a younger, smoother and enhanced skin appearance.
Additionally, previous application may improve acceptability of the electromagnetic field by increasing the temperature of the skin and the transmittance of the electromagnetic field may be improved due to less value of skin impedance. Further the radiofrequency may penetrate deeper target structures relative to treatment without a preceding magnet treatment of the target structure and/or area.
Another benefit may be releasing the adipose tissue in the muscle by muscle contraction and/or by temperature increase causing better liquidity of adipose tissue. Still another benefit of the at least partial muscle contraction may be mechanical breaking large adipose tissue bulks into smaller bulks which may be easier metabolism of the adipose tissue and/or the smaller adipose tissue bulks may be removed faster by the lymphatic and/or blood flow. Due to improved metabolism and/or circulation the cellulite may be treated in a short time and the visual effect on skin appearance may be significantly enhanced.
In another aspect of the invention, the treatment by magnetic field may be applied to the target structure simultaneously with the radiofrequency treatment to improve effects of the electromagnetic treatment inducing heat in the target structure.
The simultaneous application of magnet treatment and radiofrequency treatment may be in two modes: a first mode may generate the magnet impulses while radiofrequency treatment is active or another mode may generate radiofrequency treatment while the magnet treatment is not in an active stimulation period, i.e. the period of magnet treatment and radiofrequency treatment alternates. Both modes amplify the resulting effect of the treatment. Therefore the results are achieved in significantly shorter time than the same results achieved by separate applications of the radio frequency and magnet treatments.
The simultaneous method of magnet treatment and radiofrequency treatment of the target tissue may increase the peak magnetic component of the entire treatment resulting in improved heating of the target structure including containing higher water volume, e.g. skin. Due to increased temperature of skin, the production and/or remodeling of collagen and/or elastin fibers may be improved and the skin may be provided with a younger, smoother and enhanced appearance. The effect of overheating the muscle is reduced by the improved blood flow.
In still another aspect of the invention, the treatment by magnetic field may be applied to the target structure after the treatment by electromagnetic field to enhance and/or contribute to the effects of radiofrequency treatment by influencing the target structure by magnetic field.
The magnetic field may treat the target structure to cause at least partial muscle contraction proximate to the target structure to improve blood flow and provide homogenous temperature distribution at high quality after creating a temperature distribution at lower quality by radiofrequency treatment.
The present device and methods of its operation are related to treatment of a patient by magnetic and/or electromagnetic treatment. The electromagnetic treatment may be particularly radiofrequency treatment. The application of the magnetic and/or electromagnetic treatment may be provided by at least one energy delivery element. The device may be used for treatment or focused remodeling of subcutaneous tissue by reducing number and/or value of lipid-rich cells, cellulite treatment, body shaping and/or contouring, muscle toning, skin tightening, collagen treatment, skin rejuvenation, wrinkle removing, reducing stretchmarks, breast lifting, lip enhancement, treatment of vascular or pigmented lesions of the skin or hair removing.
The essential principle for this device is a fact that the energy delivery element, e.g. a magnetic field generating device such as a flat coil which may be preferably circular shaped, may administer the same function as an electrode if it is provided by the high-frequency signal. Hence the coil may be used to generate a radiofrequency treatment. The reason is that the frequency spectra of low-frequency signal used for generating the magnetic field is far different from frequency spectra of high-frequency signal used for generating the electromagnetic field. The signals from at least one or more preferably two generators may be provided successively, with some overlay or simultaneously due to difference of the frequency spectra. The frequency spectra of high-frequency signal used for generating the electromagnetic field may be in the range of ones of kHz to hundreds of GHz, more preferably in the range of 500 kHz to 3 GHz, most preferably above 1 MHz around 3.4 or 6.7 or 13.56 or 40.68 or 27.12 MHz or 434 MHz or 915 MHz or 2.45 GHz. The frequency spectra of low-frequency signal used for generating the magnetic field impulses may be in the range of 1 to 100 kHz, more preferably in the range of 1.25 to 10 kHz, even more preferably in the range of 2 to 5 kHz, most preferably in the range of 3 to 4 kHz. The low-frequency signal is used for generating impulses of time-varying magnetic field. The repetition rate of the pulses may reach up to 700 Hz, more preferably up to 500 Hz, most preferably in the range of 1 to 300 Hz. The magnetic flux density of the magnet treatment is at least 0.1 T, more preferably at least 0.5 T, even more preferably at least 1 T, even more preferably at least 1.5 T, most preferably at least 2 T, or up to 7 T on the surface of the energy delivery element. The energy delivery element may be integrated within an applicator, such as patient support for maintaining the patient in sufficiently sitting or recumbent position, e.g. a chair or a bed. The energy delivery element may be moveable within the patient support. Alternatively the applicator may be moveable, e.g. it may be attached to an articulated arm or it may be preferably hand-held.
The side of the energy delivery element closer to the patient may be covered by a layer of insulating material such as ceramic or epoxy coating, or bolus. The insulating material may provide electrical insulation of the patient and mechanical protection of the energy delivery element.
In an alternative embodiment the treatment device may include a plurality of HF generators and/or a plurality of LF generators.
In an alternative embodiment the treatment device may include a human machine interface for the patient. The patient may control the power in the treatment hence the patient may control e.g. temperature of the target biological structure or strength of the at least partial muscle contraction. Furthermore the patient may interrupt the treatment before any discomfort feeling may occur.
The power supply may provide energy for the treatment device via the power source 1801. The power supply may be external, e.g. a plug, or it may be integrally included within the treatment device, e.g. a battery. The power source 1801 may communicate with generators 1802, 1803. The power source 1801 may provide energy to electric components of the treatment device, particularly to generators 1802, 1803 or to control unit 1804. The power source 1801 may communicate with control unit 1804 which may provide information about power necessary for the treatment. The power source 1801 may adjust the power for generators 1802, 1803 following the information from control unit 1804 or alternatively based on direct information from generator 1802 or generator 1803.
The control unit 1804 may communicate with LF generator. LF generator may provide LF signal to energy delivery element 1806 to generate magnetic treatment. The LF generator 1803 may provide information referred to treatment process to the control unit 1804, e.g. energy loss from one impulse. In an exemplary embodiment the control unit 1804 may send instruction to power source 1801 to provide the LF generator 1803 by the energy amount equaling the energy loss. Alternatively the control unit 1804 may control recharge of the LF generator.
The energy delivery element 1806 may include at least one sensor, e.g. a temperature sensor. The energy delivery element may provide information to control unit 1804, HF generator 1802 and/or to LF generator 1803.
The control unit 1804 may communicate with HF generator 1802 to provide instructions for HF generator 1802. HF generator may provide HF signal for energy delivery element 1806 to generate RF treatment. The HF generator 1802 may provide information referred to treatment process to the control unit 1804, e.g. temperature of the energy delivery element 1806. In one exemplary embodiment RF energy transfer may be optimized prior to the treatment. In an exemplary embodiment the HF generator 1802 may include an internal power source for adjusting energy for energy delivery element 1806. Alternatively, more than one energy delivery element 1806 may be used. When using two or more energy delivery elements, the at least one energy delivery element may deliver magnetic field, the at least one energy delivery element may deliver electromagnetic field (e.g. radiofrequency field); in still another embodiment each energy delivery element may provide both magnetic field and electromagnetic field (e.g. radiofrequency field) for magnetic and electromagnetic treatment.
The control unit 1804 may be in communication with human machine interface 1805. The human machine interface 1805 may include outputting interface for providing information for the operator and/or the patient. The outputting interface may include audio output, e.g. a speaker; visual output, e.g. a display or any combination. The outputting interface may provide a notification for the operator and/or the patient in a human perceptible form such as beep, flashing light, color change or mechanical signal.
The human machine interface 1805 may include at least one input element, e.g. touch member such as touchscreen, keyboard, control member for adjusting the treatment, for providing the information from operator. The operator may adjust e.g. a treatment protocol or may adjust treatment parameters following the patient's need.
In an alternative embodiment the treatment device may include at least two control units. One control unit may administer HF generator. Second control unit may administer LF generator. In this exemplary embodiment a communication link between both control units may be established.
The energy delivery element may be used as an energy source for another part and/or electric member of the treatment device. The energy delivery element may be used as a part of transformer or antenna. In an exemplary embodiment illustrated in
In an exemplary embodiment the treatment device may include one energy delivery element. The energy delivery element, e.g. a flat coil, may be used for providing magnetic treatment and RF treatment. The energy delivery element may be provided by high-frequency and by low-frequency signal. The RF treatment may be unipolar. The high-frequency electromagnetic field may be radiated to the target biological structure. The applicator may be moveable to increase the homogeneity of the treatment. The scanning movement may be preferably used. Alternatively the movement of the applicator may follow a predetermined pattern corresponding to a treated body part. The movement of the applicator may be manual and/or automatically provided by a manipulating device, e.g. robotic arm or scanning mechanism.
The radiofrequency treatment may be applied by the energy delivery element to the target biological structure in three modes. One mode may be simultaneous application of RF treatment and magnetic treatment. Another mode may be separate RF treatment and magnetic treatment, RF and/or magnetic treatment may be applied in various sequences or it may alternate. Still another mode may be application of RF and magnetic treatment with some overlay. In an exemplary application the RF treatment may be applied prior a magnetic treatment. In another exemplary application the RF treatment may be applied after magnetic treatment.
In an alternative embodiment the treatment device may include a reference electrode to provide a monopolar application of RF treatment by the energy delivery element.
The treatment may be provided by contactless application. Alternatively the treatment may be administered in contact way or by indirect contact way by using a bolus/spacing object. The spacing object may be preferably transparent for high power magnetic field and it may include inner space filled with at least one substance. The spacing object may provide optimal distribution RF field used for treatment it may provide a cooling of the skin which it contacts.
The at least two electrodes may be connected by at least one capacitor which may provide a capacitive connection between the electrodes.
The at least two electrodes may be connected by at least one inductive member, e.g. a coil.
The treatment device may include a mathematic method including at least one of calculation and/or statistic method for monitoring correctness of the treatment and/or for monitoring the heat produced by the treatment device. The mathematic method may monitor at least one characteristic quantity of at least one operation parameter. The mathematic method may be used for determining heat generated by the energy delivery element. The generated heat may be used for additional heating biological structures in proximity. Alternatively, the energy delivery element may be less cooled to reach higher temperature for improved heating of the patient.
The applicator may be statically positioned to a predefined position to treat the target biological structure. Alternatively the applicator may be moveable during the treatment to treat larger area of the patient compared to treatment in static position. The RF energy transfer may be optimized prior to the treatment if the applicator is statically positioned and/or the treatment is provided in contact way. However, the continual optimizing of the energy transfer may be preferred for providing optimal and/or highly effective treatment to shorten the treatment duration, to improve the treatment effect and/or to achieve the desired results in shorter time period. Moreover the continual energy transfer optimizing may eliminate incorrect energy transfer caused by patient movement, e.g. caused by breath, and/or change of physiological conditions, e.g. caused by sweat, improved blood perfusion or increased temperature.
The treatment device may include a plurality of energy delivery elements, e.g. two, three, four or more. However, the even number of energy delivery elements may be used in the preferred embodiment. The at least two magnetic field device may provide a bipolar RF treatment, alternatively monopolar treatment may be provided as well. The bipolar treatment may provide homogenized temperature distribution in the target biological structure.
Transmatch may optimize the energy transfer to the patient. A function of balun is to transform unbalanced signal to balanced signal.
The power supply may provide energy for the treatment device via the power source 2401. The power supply may be external, e.g. a plug, or it may be integrally included within the treatment device, e.g. a battery. The power source 2401 may provide energy to electric components of the treatment device, particularly to both generators 2402, 2403 or to control unit 2404. The power source 2401 may communicate with control unit 2404 which may provide information about power necessary for the treatment. The power source 2401 may adjust the power for generators 2402, 2403 following the information from control unit 2404 or alternatively based on direct information from generator 2402 or generator 2403
The control unit 2404 may communicate with LF generator 2403. LF generator 2403 may provide LF signal to at least one energy delivery element 2408 to generate magnetic treatment. The LF generator 2403 may provide information referred to treatment process to the control unit 2404, e.g. energy loss from one impulse. In an exemplary embodiment the control unit 2404 may send instruction to power source 2401 to provide the LF generator 2403 by the energy amount equaling the energy loss. Alternatively the control unit 2404 may control recharge of the LF generator.
The energy delivery element 2408 may include at least one sensor, e.g. a temperature sensor. The energy delivery element may provide information to control unit 2404, HF generator 2402 and/or to LF generator 2403.
The control unit 2404 may communicate with HF generator 2402 to provide instructions for HF generator 2402. HF generator 2402 may provide HF signal for at least one energy delivery element 2408 to generate RF treatment. The HF signal may be transferred via transmatch 2406. The HF generator 2402 may provide information referred to treatment process to the control unit 2404, e.g. temperature of the at least one energy delivery element 2408 and/or information provided by transmatch 2406. In exemplary embodiment RF energy transfer may be optimized prior to the treatment. However, the continual optimizing of the energy transfer may be preferred for providing optimal and/or highly effective treatment to shorten the treatment duration, to improve the treatment effect and/or to achieve the desired results in shorter time period. Moreover the continual energy transfer optimizing may eliminate incorrect energy transfer caused by patient movement, e.g. caused by breath, and/or change of physiological conditions, e.g. caused by sweat, improved blood perfusion or increased temperature. In an exemplary embodiment the HF generator 2402 may include an internal power source for adjusting energy for at least one energy delivery element 2408.
Alternatively, more than one energy delivery element 2408 may be used. When using two or more energy delivery elements, the at least one energy delivery element may deliver magnetic field, the at least one energy delivery element may deliver electromagnetic field (e.g. radiofrequency field); in still another embodiment each energy delivery element may provide both magnetic field and electromagnetic field (e.g. radiofrequency field) for magnetic and electromagnetic treatment.
The control unit 2404 may be in communication with human machine interface 2405. The human machine interface 2405 may include outputting interface for providing information for the operator and/or the patient. The outputting interface may include audio output, e.g. a speaker; visual output, e.g. a display or any combination. The outputting interface may provide a notification for the operator and/or the patient in a human perceptible form such as beep, flashing light, color change or mechanical signal.
The human machine interface 2405 may include at least one input element, e.g. touch member such as touchscreen, keyboard, control member for adjusting the treatment, for providing the information from operator. The operator may adjust e.g. a treatment protocol or may adjust treatment parameters following the patient's need.
The control unit 2404 may be in communication with transmatch 2406. The control unit 2404 may control the function of transmatch 2406. Transmatch 2406 may be provided by instructions from control unit 2404 to optimize the energy transfer to the patient. The transmatch 2406 may include an energy source to be able to adjust the energy provided to the at least one energy delivery element 2408.
In an alternative embodiment the transmatch 2406 may be excluded from the treatment device. The embodiment may be used for contact treatment or alternatively for contactless treatment. The energy transfer may be optimized prior the treatment.
In an alternative exemplary embodiment the transmatch may be the energy delivery element. The energy transfer may be optimized by adjusting e.g. transformation ratio.
The treatment device may include balun in various locations. In one exemplary embodiment unbalanced signal from HF generator 2402 may be transformed in the balun 2407 to balanced signal which further continues to transmatch 2406 and further to at least one energy delivery element 2408.
In an alternative exemplary embodiment the balun 2409 may be located in the transmatch 2406 or between transmatch 2406 and energy delivery element.
In alternative embodiment the balun may be excluded.
The HF generator 2501 may provide HF signal to transmatch 2502 which may adjust the HF signal to optimize the energy transfer between the treatment device and the patient. The optimized HF signal may be directed to balun 2503 and to combiner 2505. In an alternative embodiment the balun 2503 may be incorporated in transmatch 2502 or may be between HF generator 2501 and transmatch 2502.
The at least one LF generator 2504 may provide LF signal to at least one combiner 2505. The combiner 2505 may provide both signals, from HF generator 2501 and from LF generator 2504, to energy delivery element 2506. The energy delivery element 2506 may provide energy to treat the target biological structure. In the particular embodiment the energy transfer (illustrated by dotted line) is defined by position of the energy delivery elements 2506. The energy transfer may be capacitive and/or inductive.
In the exemplary embodiment illustrated in
The HF generator 2501 may provide HF signal to transmatch 2502 which may adjust the HF signal to optimize the energy transfer between the treatment device and the patient. The optimized HF signal may be directed to combiner 2505. LF generator 2504 may provide LF signal to combiner 2505. The combiner 2505 may provide both signals, from HF generator 2501 and from LF generator 2504, via balun 2503 to energy delivery element 2506. The energy delivery element 2506 may provide energy to treat the target biological structure. In the particular embodiment the energy transfer (illustrated by dotted line) is defined by position of the energy delivery elements 2506. The energy transfer may be capacitive and/or inductive.
In an alternative embodiment the exemplary treatment device may include one LF generator. According to alternative embodiment only one generator providing low and high frequency may be used.
Alternatively, the transmatch may be a incorporated in balun. The energy transfer may be optimized by e.g. adjusting transformation ratio.
In still another exemplary embodiment with respect to 25A and 25B the combiners may be coupled. The coupling may be capacitive and/or inductive. Alternatively one combiner may be used. In another alternative embodiment the combiner may be excluded. The separation of the signals may be provided by mechanical layout of the energy delivery elements as described above.
The plurality of energy delivery elements may be positioned independently to each other to provide a treatment for the patient following the patient's needs. The position of the energy delivery element may be placed by the operator. The plurality of energy delivery elements may be in a plurality of applicators, e.g. each applicator includes at least one energy delivery element.
Alternatively the plurality of energy delivery elements may be positioned dependent to each other, preferably in a predefined pattern. The position of the plurality of the energy delivering elements may provide a treatment characterized by a phase shift.
The treatment device may include a plurality of applicators. Each applicator may include at least one energy delivery element. The applicator may be moveable during the treatment, the energy delivery element may be movable within the at least one applicator as well.
Alternatively the plurality of energy delivery elements may be positioned within one applicator having form of mechanical holder. The shape of the applicator having form of mechanical holder may be adjustable, e.g. the applicator may include at least one moveable part. In a preferred embodiment the applicator having form of mechanical holder may provide spatial arrangement of the energy delivery elements in one axis, two axes or three axes and/or provide tilting and/or rotation. The applicator having form of mechanical holder may provide fixation of the at least one energy delivery element in one position. The moveable parts may be connected by sliding mechanism and/or by a joint mechanism. The at least one part of the applicator may include at least one energy delivery element. The applicator may be adjustable following the treated area and/or biological structure.
The static position of the at least one applicator may be provided by a positioning member. The positioning member may be e.g. an arm or an adjustable flexible belt. The positioning member may include a buckle for adjusting the length of the belt. The applicator may be placed within predefined locations of the belt. Alternatively the applicator may be shaped to be moveable along the positioning member, e.g. the shape of the applicator may be preferably concave, e.g. V-shaped or U-shaped. The positioning member may be inserted itself into the concavity of the applicator. The position of the applicator may be adjusted by limited movement along the positioning member because the positioning member may be used as guiding member. However, the applicator may not be fixed to a particular static position. The position of the applicator may be dynamically adjusted during the treatment following the patient's needs. The position of the applicator may be adjusted manually by the operator, or automatically by the treatment device. In one exemplary embodiment a plurality of applicators may be used for treating larger body part, e.g. buttocks, abdomen or thigh.
Alternatively, the at least one energy delivery element, e.g. a coil, may be positioned below the at least one electrode. The energy delivery element may be positioned in between the electrode and the patient.
The at least one energy delivery element may influence at least one another energy delivery element while using the plurality of energy delivery elements. The correct treatment may be controlled via the mathematic method used for monitoring the at least one characteristic quantity of the operation parameter. The mutual positon of the energy delivery elements may be evaluated by the mathematic method as well. Hence the mathematic method may prevent providing the patient with incorrect treatment caused by incorrect position and/or orientation of at least two energy delivery elements. Furthermore the mathematic method may prevent the treatment device from affecting any conductive parts by the generated treatment, e.g. an additional heat may be generated.
The mathematic method may be further used for determining temperature and/or heat generated by at least one energy delivery element. Hence the mathematic method may be used for controlling a cooling of the energy delivery element, e.g. flow of the cooling media may be regulated. The heat generated by the energy delivery element may be further used for heating the patient.
The treatment system for creating the electromagnetic field can use bipolar electrodes, where electrodes alternates between active and return function and where the thermal gradient beneath electrodes is during treatment almost the same. The system may alternatively use monopolar electrodes, where the return electrode has sufficiently large area in contact with skin of patient and is typically positioned a relative larger distance from the active electrode. A unipolar electrode may also optionally be used.
Referring now to
The microprocessor control unit with user interface 274 provides communication between the transmatch and generator control unit 273 and user interface, which may be a touch screen on the device display.
The transmatch and generator control unit 273 receives information from the operator via the control unit and regulates the operation of the HF generator 272 and the transmatch 275. The transmatch transmits HF to a balun transformer 276, which converts unbalanced impedance to balanced impedance. This processed signal goes to two capacitive applicators 277, which may be positioned 0.5 cm or higher above the surface of the skin or applied on dielectric or insulating, non-conductive material which is in contact with the skin surface.
Dielectric loss is created, as part of an AC electromagnetic field power is converted to heat in the dielectric. During this process, ions accelerate and collide, polar molecules rotate, non-polar molecules undergo distortion and these movements produce thermal energy. Skin and muscle are largely not affected by electromagnetic field 287 as they contain water and the blood, circulartion provides for cooling. Bone 286 gets little if any heating because the applicators 281 are positioned to create a field only on the upper structures. The lipid cells of the adipose tissue contain less water than any surrounding tissue and are therefore heated at higher level than any surrounding tissue.
An air gap or material with high air permeability may be placed between the skin and the applicator. This arrangement uses the human thermoregulatory system for cooling and avoids the need of artificial cooling of the skin. Additionally to enhance evaporation, airflow circulation between patient's skin and the applicator may be increased using a stream of chilled or room temperature air.
If more than one applicator is used, applicators may be positioned on opposite sides of the patient. A spacer may be positioned between one or more applicator and the skin of the patient. The electromagnetic waves may be transmitted in the range of 13.553-13.567 or 26.927-27.283 or 40.66-40.70 MHz or 2.4-2.5 GHz from the applicator into the subcutaneous tissue. The temperature of the skin surface may be increased to about 32-45° C.
One or more of the applicators may have a temperature sensor which measures and monitors the temperature of the treated tissue. Temperature can be analyzed by a microprocessor control unit. The temperature sensor may be a contactless sensor (e.g. infrared temperature sensor), contact sensor (e.g. resistance temperature detector) or invasive sensor (e.g. a thermocouple) for exact temperature measuring of deep or shallow tissue of human skin. The microprocessor controller may use algorithms to calculate the deep or shallow temperature based on the surface temperature of the skin. A feedback system may be used to measure and control temperatures on the skin surface or below the skin surface. The feedback system may control the temperature to a predetermined level, for example by adjusting power, airflow circulation, phase shifting, supplemental magnetic field, and perhaps other parameters, or combinations of them.
The present device and method use a combination of non-invasive, preferably contactless, applications of different methods for enhancing human appearance. Particularly, the present invention uses a combined treatment by time-varying magnetic field and optical waves.
The treatment is defined by application of electromagnetic waves of wavelength in the range of 635 to 1100 nm, with maximal power flux density up to 100 W/cm2. Alternatively, in the case of pulse light, the power flux density may be up to 100 W/cm2 with light pulses lasting up to 300 ms, however, preferably in the range of 1 to 20 ms. Optical treatment may be used for inducing heat generation within the adipose cells over physiological temperature.
The treatment by optical waves may be combined with application of magnetic treatment inducing at least partial muscle contraction.
The presented methods enable aesthetic applications providing significant reduction of number and/or volume of adipose cells and cause circumferential reduction i.e. a reduction of the size of the treated body area. Furthermore, the treatment method induces at least partial muscle contraction to provide muscle toning, muscle shaping, body contouring, body shaping or skin tightening effect. Additionally, strong muscle contractions at high repetition rate may cause mechanical movement of all the layers in proximity of the contracted muscle. The method therefore may cause remodeling and/or neogenesis of the collagen and elastin fibers.
Optical treatment may selectively heat the target biological structure. Hence optical treatment may remove and/or remodel adipose tissue. Before/after, with some overlap or simultaneously the magnetic treatment of the target biological structure may induce at least partial muscle contraction within the target biological structure to remodel the adipose tissue by natural adipose tissue catabolism. Adipose tissue catabolism may be caused by apoptosis and/or necrosis of the adipocytes. The muscle contraction caused by induced eddy current is equivalent to a natural contraction. The adipose tissue may be reduced in natural way. Additionally, the muscle may be toned and/or shaped in a natural way. Therefore the effect resulting in body shaping and/or contouring may be significantly improved.
The present methods provide advanced approaches in aesthetic applications. Combined methods of treatment by optical treatment and treatment by magnetic field are used. The optical treatment may include treatment by optical waves. The magnet treatment may be provided by permanent magnets, electromagnetic devices generating a static magnetic field or preferably by magnetic devices generating time-varying magnetic field. In the preferred application the method may combine treatment by a pulsed magnetic field and optical treatment. The application is not limited by the recited combination so the combined method may include magnetic treatment and any treatment by electromagnetic field such as radiofrequency waves, e.g. microwaves, short waves or long waves.
The basic parts of the optical irradiation system include a hardware panel and an optical waves generating device or multiple optical waves generating devices. The optical waves generating device may be arranged in an array. The optical waves generating devices may be attached to each other or alternatively be individually mounted on dedicated supports. A scanning system may also be one of the options.
At least one optical wave generating device and a magnetic field generating device are provided. An optical treatment device may include at least one energy source and/or connection to the energy source, a hardware panel for controlling the optical treatment device and an optical waves generating device. Non limiting examples of optical waves generating device that may be used include light emitting diodes, lasers, laser diodes, different types of lamps and filtered lamps or combinations thereof. The treatment device may include at least one optical waves generating device, more preferably a plurality of optical waves generating devices of wavelength from ultraviolet, visible and infrared spectrum ranges. The wavelength may be in the range of 190 to 13000 nm, preferably in the range of 290 to 3000 nm, more preferably in the range of 400 to 1500 nm, even more preferably in the range of 550 to 1450 nm, particularly wavelengths about 915, 1064, 1208 and 1715 nm may be used.
The plurality of optical waves generating devices may generate optical waves simultaneously. The plurality of generated optical waves may interfere. Alternatively the plurality of optical waves generating devices may generate a plurality of independent optical waves at different times, preferably in sequences. The plurality of optical waves generating devices may be arranged in a predefined pattern within an applicator, e.g. in an array or a matrix.
The optical treatment applicator may be preferably external (e.g. hand-held). Alternatively, the optical treatment applicator may be an integral part of the optical treatment device (e.g. chair/bed implemented). Additionally, optical delivery elements, such as optical waveguides, light tubes or optical gel, may be used.
The magnetic treatment applicator may be an integral part of the treatment device, or it may be preferably external part of the treatment device (e.g. hand-held), alternatively the magnetic treatment applicator may be an integral part of the magnetic treatment device (e.g. chair/bed implemented).
According to one embodiment the magnetic treatment and optical treatment may be provided by at least two separate devices, i.e. at least one device for administering the magnetic treatment and at least one device for administering the optical treatment. The optical treatment may be applied to target biological structure prior, after or with some overlay with magnetic treatment. Alternatively optical treatment may be applied simultaneously with magnetic treatment. The time consequences of the treatment are described below.
In an alternative embodiment the at least one optical waves generating device may be in the treatment device. The optical waves may be delivered to the applicator and/or to the target biological structure by a waveguide.
According to another embodiment the magnetic treatment and optical treatment may be provided by one device. The combined treatment provided by one device may be administered by at least one applicator.
In an alternative embodiment the at least one optical waves generating device may be in the treatment device. The optical waves may be delivered to the applicator and/or to the target biological structure by a waveguide.
In an alternative embodiment the optical waves generating devices may be in the treatment device. The optical waves may be delivered to the applicator and/or to the target biological structure by a waveguide.
In an alternative embodiment the optical waves generating devices may be in the treatment device. The optical waves may be delivered to the applicator and/or to the target biological structure by a waveguide.
In an alternative embodiment the at least one optical waves generating device may be in the treatment device. The optical waves may be delivered to the applicator and/or to the target biological structure by a waveguide.
According to still another embodiment the magnetic field generating device may be used as an energy source for providing energy to another part of the treatment device, e.g. an optical waves generating device such as light-emitting diode (LED).
Biocompatibility issues or hot spot generation may be overcome by transmitting electromagnetic energy into the target biological structure without physical contact with the patient. Contactless application of magnetic and/or optical treatments may provide sufficient passive cooling of the biological structure by circulating air.
In some indications, it may be advantageous to treat deeper adipose tissue by magnetic field simultaneously with the treatment of more superficial layers of the skin by optical waves.
An air gap or bolus material with high air permeability may be placed between the skin and the applicator. The material may be preferably transparent to the optical waves. This arrangement uses the human thermoregulatory system for cooling and avoids the need of artificial cooling of the skin. Optionally, the skin may be cooled via a stream of chilled or ambient temperature air. The human thermoregulatory system enables perspiration and other body fluids to evaporate and cool the surrounding skin. The application of electromagnetic waves is contactless. Therefore sweat accumulation and/or hot spot creation are avoided. Use of cooling fluids or gels is not necessary but may be optionally used. Cost of the treatment is reduced and patient comfort is improved. The applicator may be in direct or indirect contact with patient's skin. A bolus device may be used for providing indirect contact of the applicator with the target biological structure. A bolus may be filled with a material, preferably a fluid, influencing the propagation of the electromagnetic waves and/or homogenizing the temperature distribution of the patient's skin. Alternatively the bolus may deliver the electromagnetic waves to the target biological structure, e.g. a waveguide.
Cooling may be provided by positioning an air moving device proximate to the skin. The air moving device may be attached to or implemented into the applicator. Air moving device may be any kind of fan, ventilator or blower. The blower may include an air tube connected to air source for moving air through the air tube to the patient's skin. The air source may alternatively be cooled to provide cooled air. Alternatively, air suction may be also used as an active cooling method.
One or more applicators may move in the vicinity of the patient's body. The movement may be provided in various speed and/or acceleration. It may be moved in at least one direction, e.g. longitudinal, vertical, transversal or different axis and/or by rotational movement around any direction. Plurality of applicators may move in synchronized, randomized and/or independent manner. At least one applicator of the plurality of applicator may be static.
The homogeneity of treatment may be provided by the movement of the applicator. In one exemplary embodiment the applicator may move over and/or in different angle to the patient by rotational movement. In another exemplary embodiment the applicator may move in the vicinity of patient's skin. In still another exemplary embodiment the applicator may move to focus the treatment.
The movement of at least one applicator may provide a treatment pattern. The pattern may be, e.g. linear, wavy, circular, elliptical, zigzag, polygonal, oval, irregular and/or any combination thereof. In one exemplary application the at least one applicator may be positioned to the vicinity of thighs and the effect of treatment may be limited to these parts. In another exemplary application the at least one applicator may be positioned over the patient's abdomen to treat e.g. adipose cells.
The movement of the applicator may also provide a treatment to large body part, e.g. buttocks, abdomen or thigh.
The sensor may be connected with the hardware panel for controlling the optical treatment to adjust the power flux density applied to the biological structure to maintain the temperature of the target biological structure within treatment range. The temperature sensor also prevents the patient from any thermic damage.
Optical treatment may be used for remodeling, reducing the volume and/or number of adipose cells, body contouring or tightening skin, skin rejuvenation, wrinkles and/or stretch mark reduction, mole mark removal, tattoo removal, enhanced skin tightening, hair removal, treatment of vascular lesions, acne treatment, sweating reduction and other appearance improving and/or pain relief treatment without contacting the skin. The treatment may optionally be performed simultaneously or consecutively during the same session.
The commonly targeted skin chromophores are hemoglobin, melanin, carbon or tattoo ink. Alternatively water may absorb the optical waves. Each chromophore has unique absorption spectrum. The wavelength of the optical wave should match one of the absorption peaks of the targeted chromophore. The lasers or laser diodes work usually in pulse regime in these applications. The optical energy absorbed by the chromophore is converted to thermal energy thereby destroying the targeted cells. Selection of the best adapted wavelength, power and pulse duration allows achieving optimal effect on targeted biological structure with minimal effect on surrounding tissue.
The application of optical treatment may be improved by application of exogenous chromophores to the target biological structure. The exogenous chromophores may be applied in form of topical lotion, or may be delivered to the target biological structure by micro-invasive or invasive way such as injected.
According to the parameters of the optical waves used, different layers of the skin and different biological structures may be selectively treated. Various wavelengths, powers, pulse durations and repetition rates of electromagnetic radiation are applicable to provide the advantage of vast variability of penetration and absorption parameters. The operator may also adjust the optimum treatment time for each wavelength and the time sequences of treatments by different wavelengths, while some of them may overlap in time. In this way, a tailor-made solution for each patient and each indication is available. The treatment may be highly selective to reduce or avoid damage of the surrounding tissues.
Combinations of a plurality of optical waves generating devices allow performing the treatment of plurality of target biological structures at the same time and/or treating the same target tissue simultaneously by different means, which optimizes the doses of radiation applied. This diversification may also eliminate the risk of overheating, as the optical treatment with parameters leading to no or negligible thermic effect may be used. As a result, the risk of heat damage may be considerably reduced.
If the patient has more imperfections to be treated situated in the same body areas, it is also possible to treat them simultaneously by different types of electromagnetic waves. Each of the electromagnetic waves may be adjusted to optimum parameters for the target biological structure imperfection treatment. Thus the time of patient and of the operator is reduced, reducing the treatment cost.
The optical waves thermal effect may lead to temperature increase in the dermal and the sub dermal tissues also affects the triple-helix structure of collagen fibers contained in such tissues. This may result in remodeling and rejuvenation of collagen, increase of skin density and dermal thickening based on neocollagenesis. Skin tightening may also be achieved. In one aspect, the present methods selectively treat deep human tissue containing low volume of water, such as adipose tissue. Optical energy is provided to the skin by optical waves generating device. Remodeling and reducing the volume and/or number of adipocytes or skin tightening in the targeted areas may change the overall appearance of the body. Therefore it may be used for body contouring, body shaping and cellulite treatment.
Optical energy may be provided to the skin by at least one optical waves generating device in pulse or continuous mode. Optical energy is provided through the skin to the underlying dermal and/or subdermal tissue, without contacting the skin. The radiant energy may be converted inside the target tissue to heat. The radiant energy enables treating of the adipose tissue and/or collagen tissue, accelerating apoptosis and/or cell lysis (e.g. adipose cell), based on amount of energy transmitted to target biological structure. At the same time the triple helix structure of collagen fibers may result in remodeling and/or rejuvenation of collagen, increase of skin density and dermal thickening based on neocollagenesis. In an alternative embodiment the radiant energy enables treating of target tissue resulting e.g. in neocollagenesis without adipose tissue reduction. Target tissue may be remodeled and/or reduced and body contouring and/or skin tightening effect may occur.
Cooling may also be used to modify and to optimally adjust the depth of optical radiation penetration. Light penetration may be enhanced if cooling is used before phototherapy. The effects of heating in terms of light penetration are the opposite.
Optical treatment may treat the same or different skin layers as the magnetic treatment. As mentioned above, optical treatment may also be used for multiple rejuvenation and appearance enhancing applications. Another important indication is drug-free and addiction-free pain relief in many conditions.
Non-limiting examples of optical therapies that may be preferably used in combination with the treatment by magnetic field according to the present invention are: low level light therapy (LLLT), photodynamic therapy (PDT), high power laser therapy (HPLT) or intense pulsed light (IPL). However, the scope of the invention is not limited only to these particular optical irradiation methods. Other electromagnetic waves may be used, e.g. a radiofrequency treatment. The power flux density of the optical wave therapy may be in the range to 0.1-100 W/cm2, more preferably in the range to 0.5-50 W/cm2, most preferably 0.5-20 W/cm2.
Low-level light therapy is one of the methods of non-invasive rejuvenation with no or a very small thermal effect. LLLT may be effective throughout the visible, infrared and near ultraviolet spectrum ranges. The term low level refers the fact that the levels of energy or power densities are low compared to other forms of light treatment such as by lasers, which are applicable for cutting, thermal coagulation or thermal damage, such as ablation. Treatment energies in LLLT are limited to 0.1-20 or a few J/cm2 and/or by a power of 1 mW to 500 mW per optical waves generating device. The depth of penetration of the low level light radiation depends on parameters of the optical waves generating device such as wavelength, operating mode, which may be pulse or continuous, the power output, the probe design and the treatment technique. The depth of penetration where the light still has therapeutic effects should match the depth of the desired zone to be treated. The penetration depth is lower than in HPTL, up to several tens of mm approximately. Due to the low levels of absorbed energy, the treated and surrounding biological structures are not heated and are not damaged. Although many wavelengths may be used, it is advantageous to use at least one beam in the visible spectrum so that the area of application on the patient's body may be easily determined by the operator.
LLLT uses either coherent optical waves generating devices such as lasers or laser diodes or non-coherent light sources including incandescent lamps, gas filled lamps, filtered lamps optimized for a particular wavelength, light-emitting diodes, etc. A combination of any types of optical waves generating devices may be also used, as well as a plurality of optical waves generating devices of the same type.
The photons emitted by the low level optical waves generating devices used in LLLT therapy may be absorbed by endogenous mitochondrial chromophores in skin. Consequently, many processes may be activated, e.g. electron transport, increased adenosine triphosphate (ATP) production, enhanced blood micro-circulation, collagen production increase, dermal matrix remodeling etc. LLLT may thus successfully treat a multitude of conditions that require stimulation of healing, acute/chronic pain relief or restoration of function. LLLT has beneficial effects on wrinkles, scars including acne scars, stimulating the scalp in hair treatment, healing of burns, skin tightening, anti-oedematous effects, regeneration after sport etc. Inflammatory skin diseases such as psoriasis or acne may be also treated by the proposed treatment. In pigmentation disorders such as vitiligo, LLLT may increase pigmentation by stimulating melanocyte proliferation.
LLLT may influence also reduction of number and/or volume of adipose cells. It is believed that the incident optical waves produce transient pores in adipose cells, allowing lipids to leak out into the interstitial space of adipose tissue. If the parameters are appropriate, the pores close upon cessation of the energy application and the cell membrane returns to contiguity. The adipose cells are not destroyed, but temporary opening within the cell's membrane induced by the optical waves may provide a pathway for lipid to exit the cell and in the end also the patient's body. It may leads to the reduction of number and/or volume of adipose cells. This adipose cell number and/or volume reduction may restore proper adipose cells function thereby acting as an anti-diabetes mechanism.
It is advantageous to combine LLLT and magnetic treatment for safe and efficient target biological structure treatment.
While in LLLT the light is absorbed by endogenous cellular chromophores, PDT may be based on introduction of exogenous photosensitizers into the cells which are then irradiated with wavelengths of visible or near infra-red light. Photosensitizer drugs may become activated by one or several types of optical waves. The optimal type of optical waves depends on the target biological structure and the absorption peak of the particular chromophore drug used. PDT optical waves generating devices include laser, intense pulsed light, light-emitting diodes or many visible lights including natural sunlight, etc.
Unlike LLLT HPLT has pronounced thermal effects on the skin. HPLT lasers having an output of 500 mW or greater may be used for this treatment, with energy densities greater than 10 J/cm2. High power allows extremely high penetration of the optical waves, in order of ten centimeters or even more, ensuring that the right dose actually reaches the target biological structure localized deep in the tissue. Laser may be precisely adjusted due to its monochromacy and coherency. Therefore its propagation and targeted biological structure may be finely pre-defined. Research shows that biological structures treated by HPLT are stimulated to increase production of adenosine triphosphate (ATP). Similarly to LLLT, the biological responses to increased ATP production may include reduction of inflammation, reducing scars, increased cell metabolism, improved vascular activity, and accelerated healing. It may improve regeneration after sport. Significant improvements of many post-traumatic pathologies or osteoarthritis have been noted, as well as temporary relief of stiffness and muscle spasms. It is important to note that HPLT also may provide the patients with drug-free and addiction-free acute and/or chronic mediation of pain, by decreasing inflammation and/or swelling and by increasing the release of endorphins and enkephalins. Moreover, if a pulse regime is applied, the wavelength-specific photomechanical wave generated in the tissue may stimulate free nerve endings, thus blocking pain pathways in the nervous systems and bringing immediate pain relief.
High power lasers, laser diodes or intense pulse light sources (IPL) may be also used for treating pigmented targets in the skin by selective photothermolysis. Such high power lasers reaching sufficient power density to vaporize illuminated cells may be gas lasers such as CO2 or excimer laser, solid-state lasers such as rubin, Nd:YAG or Er:YAG laser, semiconductor lasers, dye lasers such as Rhodamin 6G laser etc.
IPL may be used also for other skin treatments with therapeutic or rejuvenating effects, sharing some similarities with high power laser treatment. In both cases, optical waves are used to destroy the target. But unlike lasers that use a single wavelength of light which typically matches only one chromophore, and hence only one condition, IPL uses a broad spectrum of wavelengths. When used with filters, it may be adapted to treat various conditions. This may be achieved when the IPL operator selects the appropriate filter that matches a specific chromophore. Such filter may be represented by an optical material filtering e.g. 480 nm, 530 nm, 560 nm, 640 nm or 690 nm.
The optical energy flux density of the IPL treatment may be in the range of 1 and 50 J/cm2, preferably in the range of 2 to 40 J/cm2, more preferably at least 5 J/cm2, or up to 100 J/cm2. The optical waves may be applied continually or in pulses. Pulse width is time duration that the target is exposed to the optical waves, it is measured in miliseconds. Pulse width is shorter than thermal relaxation time of the target, i.e. the pulse width is long enough to allow heating of the target but also short enough that the target is able to cool so that there is no heat buildup in surrounding skin and tissue. The pulse width may be in the range of 1 to 300 ms, preferably in the range of 5 to 50 ms, most preferably up to 30 ms.
Optical waves may penetrate the skin and increase the temperature of adipose cells and thermally damage the adipose cells. Hence the optical treatment may be used for reducing number and/or volume of adipose cells, remodeling treated body parts, or improving the skin appearance. The target biological structure, e.g. adipose cells, may be exposed to increased temperature. The temperature may be in the range of 37.5 to 60° C., more preferably in the range of 40 to 50° C., most preferably in the range of 42 to 47° C., or up 80° C. The damaged adipose cells may be removed by blood and/or lymphatic system to be metabolized. The heat generated in the target biological structure may induce a production of growth factors and/or fibroblasts which may improve collagen neogenesis and/or new vein formation to support the newly generated collagen formations.
Optimal wavelength should include low absorption within the skin, i.e. low absorption of water and/or melanin, and high absorption within the adipose cells. The optical waves may be in visible or in IR spectrum such as near-IR spectrum, e.g. in the range of 600 to 1500 nm in a plurality of applicable bands e.g. in the range of 635 to 680 nm, particularly 658 nm; or in the range of 780 to 980 nm, particularly 800 nm or 940 nm; or in the range of 1050 to 1100 nm, particularly 1060 nm due to relatively high penetration through the skin. Alternatively the optical waves may be in the range of 1300 to 1450 nm, particularly 1320 and 1440 nm may be applicable.
The optical treatment may last up to 120 minutes, preferably in the range of 1 to 60 minutes, more preferably in the range of 20 to 40 minutes. The treatment time may be dependent on BMI of the patient. The power flux density of the optical treatment may be up to 50 W/cm2, preferably up to 25 W/cm2, more preferably in the range of 1 to 15 W/cm2, most preferably in the range of 2 to 10 W/cm2 such as at least 5 W/cm2. In the preferred application power modulation may be used.
Optionally, active cooling may be included. However, in many cases, auto thermoregulation by sweating is sufficient. The active cooling may be administered in continual mode or in pulsed mode to maintain the skin temperature within physiologic temperature, i.e. around or below 37° C.
Alternatively, optical treatment by high power optical waves generating device may be used for treatment of incontinence or menorrhagia. One exemplary application may be inserting the optical wave generating device into the body cavity, e.g. a vagina, and treating the target biological structure by selectively heating. A suitable probe may be used for inserting the optical waves generating device. The target biological structure may be tightened due to increased temperature and/or improved collagenesis. Alternatively the optical wave generating device may be external to the body cavity and the optical waves may be delivered to target tissue by optical delivery element.
An exemplary application of application combined treatment by optical waves and magnetic treatment may be application to enhancing appearance of genitalia, e.g. external female genitalia such as labia minora, labia majora and/or clitoris. Furthermore collagenesis may be improved in vagina hence it may be smoother and/or firmer. Therefore the combined treatment may enhance physical pleasure during coitus.
Optimal wavelength of the optical waves may be in the range of 400 to 600 nm, particularly around 500 nm. Energy density may be up to 25 J/cm2, more preferably up to 10 J/cm2, most preferably in the range of 1 to 8 J/cm2. Treatment may be administered in continual or preferably in pulsed mode.
Alternatively, the application of optical waves may provide disinfection effect. Such application may include application of UV light, e.g. UV-B and/or UV-C light. The wavelength of the optical waves may be in the range of 200 to 300 nm, most preferably in the range of 250 to 270 nm. The optical radiation may destroy the DNA of microorganisms such as bacteria, or virus. The nucleic acid in DNA may form a covalent bond (such as thymine dimer) preventing unzipping process during reproduction cycle. Hence the replication ability of the microorganism is disabled and the microorganism may die and the infection may be treated. The power density may be up to 300 mW/cm2, preferably up to 200 mW/cm2, or in the range of 1 to 50 mW/cm2, more preferably in the range of 5 to 25 mW/cm2 In one exemplary application the UV light may be in external flow-chamber to provide disinfected air to the treated area.
Similar application of optical waves may be used for cleaning the skin of the patient.
The treatment by a combination of magnetic field and optical waves significantly improves the treatment effect. Most preferably, the optical waves include wavelengths ranging from 405 to 1500 nm. At least one optical waves generating device and at least one magnetic field generating device may be used.
The methods described are more gentle and efficient in adipose cells treatment or skin tightening since the target biological structure is treated by magnetic and/or by electromagnetic field.
The application of magnetic and optical treatment may be used for treatment of pelvic floor area disorders, e.g. gynaecologic and/or urologic issues such as incontinence. The magnetic treatment may be targeted to the area of pelvic floor to treat pelvic floor muscles. The repetition rate of the magnetic pulses may be in the range of 1 to 150 Hz, preferably up to 100 Hz, more preferably in the range of 5 to 70 Hz, e.g. at least 30 Hz. The optical treatment may selectively raise a temperature in the vagina to provide tightening effect. Alternatively the optical treatment may provide biostimulation effect to promote neocollagenesis. The tightening effect may be also promoted by at least partial muscle contraction. Hence the treatment of incontinence may be provided by different energy types. The collagenesis may be improved by application of magnetic treatment improving local metabolism by improved blood flow and/or at least partial muscle contraction.
Another application of magnetic and optical treatment may be used for treating a pain. The pain relieving effect may be combined and significantly improved due to different applied energies and different approaches of relieving the pain. The pain relief is drug-free and may last up to several hours after the treatment. The pain relieving may be applied for treatment of chronic and/or acute pain. Alternatively, the pain relieving effect caused by magnetic and/or optical treatment may be used for improving acceptability of optical treatment provided by high power density optical radiation, e.g. high power laser or IPL.
Still another application of magnetic and optical treatment may be used for causing relaxing effect. High efficient relaxation may be caused by combined influence optical and magnetic treatment on the biological structure.
Still another application of magnetic and optical treatment may be used for treating the adipose cells. The adipose cells may be heated by the optical treatment above 37.5° C., more preferably above 40° C., most preferably in the range of 40 and 50° C., or up to 60° C. The temperature increase may induce apoptosis and/or necrosis of the adipose cells. The apoptosis of the adipose cells may be preferred effect due to reduced risk of inflammation and/or panniculitis occurrence. The temperature increase may also liquefy the adipose tissue. The magnetic treatment may contribute the optical treatment by inducing the at least partial muscle contraction which may improve the local blood and/or lymph circulation and/or local metabolism. Hence the death adipose cells may be removed faster from the human body. The apoptosis of the adipose cells may be also contributed by the influence of the magnetic treatment to metabolism of Ca ions as was described before. The optical waves may be in visible or in IR spectrum such as near-IR spectrum, e.g. in the range of 600 to 1500 nm in a plurality of applicable bands e.g. in the range of 635 to 680 nm, particularly 658 nm; or in the range of 780 to 980 nm, particularly 800 nm or 940 nm; or in the range of 1050 to 1100 nm, particularly 1060 nm due to relatively high penetration through the skin. Alternatively the optical waves may be in the range of 1300 to 1450 nm, particularly 1320 and 1440 nm may be applicable.
The optical treatment may last up to 120 minutes, preferably in the range of 1 to 60 minutes, more preferably in the range of 20 to 40 minutes. The treatment time may be dependent on BMI of the patient. The power flux density of the optical treatment may be up to 50 W/cm2, preferably up to 25 W/cm2, more preferably in the range of 1 to 15 W/cm2, most preferably in the range of 2 to 10 W/cm2 such as at least 5 W/cm2. In the preferred application power modulation may be used.
Still another application of magnetic and optical treatment may be used for treating the cellulite. As was mentioned above the adipose cells may be influenced by apoptosis and/or necrosis. Alternatively the adipose cells may be liquefied. The adipose cells metabolism may be contributed by the at least partial muscle contraction. Furthermore the application of optical treatment may heat the fibrous septae of the cellulite. The heated septae may be straightened by the at least partial muscle contraction caused by the magnetic treatment. Further the at least partial muscle contraction may remove the water from the cellulite tissue to reduce the cellulite. Therefore more significant results may be achieved in shorter time periods. The above mentioned methods may be combined hence the enhanced effect may be induced. Hence the results may be achieved in shorted time period and may be more significant.
Still another application of magnetic and optical treatment may be used for enhancing body shape and/or improving muscle tonus to enhance visual appearance of the body part. According to one application, the muscle may be treated by the optical treatment to increase the temperature of the muscle. Afterwards the heated muscle may be treated by magnetic treatment. The magnetic treatment may achieve more significant results due to increased temperature of the muscle. The muscle may be toned and/or strengthened more effectively. The toned and/or strengthened muscle may induce body shaping effect to enhance visual appearance of the treated body part. Moreover the results may be achieved without hours spent by exercising of the muscle which may achieve unpredictable results within different body parts. The effectiveness of the magnetic treatment may be enhanced by preheating of the muscle by optical treatment. Magnetic treatment may be provided at repetition rate of at least 0.1 Hz, more preferably at least 5 Hz, even more preferably at least 20 Hz, most preferably at least 50 Hz, or up to 700 Hz. The magnetic treatment may be preferably modulated.
Still another application of magnetic and optical treatment may be used for focused treating of specific muscle structures, e.g. buttocks. The demand for enhancing visual appearance of the buttocks has rapidly increased during last few years. The combined treatment may enhance the visual appearance of the buttocks by thermal effect caused by optical treatment and/or by muscle exercising effect by focus magnetic treatment. The magnetic treatment may be selectively focus to enhancing the visual appearance of the buttocks by shredding and/or toning of the buttock muscles such as gluteus maximus, medius and/or minimus.
Alternatively, the combined focused treatment may be used for causing breast lifting effect by preheating effect of the Cooper's ligament and following magnetic treatment with increased effectiveness. The treatment may lift the breasts up.
Still another application of magnetic and optical treatment may be used for skin rejuvenation. The optical treatment may be applied to cause micro-damages within the skin to promote the increase production and/or regeneration of collagen fibers. It may induce the enhanced visual appearance of the skin which may look well-toned, smoother and/or firmer. The optical treatment may be contributed by magnetic treatment causing at least partial muscle contraction which may induce the increase local metabolism and/or blood circulation. Hence the sufficiency of nutrients may be delivered to the target biological structure to promote its regeneration and/or production process.
Still another application of magnetic and optical treatment may be used for treating the wrinkles. The optical treatment may remove the wrinkles by resurfacing of the skin. Different wavelength may promote the growth of collagen and/or elastin fibers to provide the skin younger, firmer and/or smoother appearance. The optical treatment may be contributed by magnetic treatment causing at least partial muscle contraction which may induce the increase local metabolism and/or blood circulation. Hence the sufficiency of nutrients may be delivered to the target biological structure to promote its regeneration and/or production process.
The optical treatment may provide to the target biological structure the optical waves of wavelength in the range of 500 to 3000 nm, several wavelengths may be applicable for the treatment of wrinkles e.g. 590, 640, 695, 800, 1320 or 2940 nm. Alternatively other wavelengths may be also used. The energy delivered to the target biological structure may be up to 50 J/cm2, more preferably up to 25 J/cm2, most preferably in the range of 1 to 15 J/cm2.
Still another application of magnetic and optical treatment may be used for treating the scars and/or stretchmarks. The optical treatment may enhance the visual appearance of scars and/or stretchmarks by providing improved the growth of collagen and/or elastin fibers to provide the skin younger, firmer and/or smoother appearance. The optical treatment may induce micro-damages to collagen and/or elastin fibers to promote their regeneration and/or production. The optical treatment may be contributed by magnetic treatment causing at least partial muscle contraction which may induce the increase local metabolism and/or blood circulation. Hence the sufficiency of nutrients may be delivered to the target biological structure to promote its regeneration and/or production process. Furthermore the at least partial muscle contraction may straighten the newly produced collagen and/or elastin fibers by massaging effect.
Still another application of magnetic and optical treatment may be used for lip visual appearance enhancing effect. The optical treatment may improve the growth of collagen and/or elastin fibers to provide younger, fuller, firmer and/or smoother appearance. The optical treatment may be contributed by magnetic treatment causing at least partial muscle contraction which may induce the increase local metabolism and/or blood circulation. Hence the sufficiency of nutrients may be delivered to the target biological structure to promote its regeneration and/or production process.
The above mentioned methods may be combined hence the enhanced effect may be induced. Hence the results may be achieved in shorted time period and may be more significant.
Optical treatment may be applied before the magnetic treatment. The effect of the optical treatment may be stimulating, e.g. increasing the temperature of the target biological structure to prepare a target biological structure to be treated by magnetic treatment inducing at least partial muscle contraction. To enhance the efficiency of the treatment in some indications, it may be advantageous to preheat the tissue by infrared radiation prior to magnetic treatment or combined magnetic and optical treatment.
Alternatively the effect caused by optical treatment may increase the temperature of the target biological structure, e.g. adipose cell or fibrous septae. It may be contributed by magnetic treatment causing at least partial muscle contraction. The at least partial muscle contraction may provide a massage effect for biological structures within proximity of the target biological structure, improve the blood and/or lymph circulation to improve local metabolism. Additionally the at least partial muscle contraction may reduce the number and/or volume of the adipose cells by energy used for the at least partial muscle contraction itself. Moreover, homogenous temperature distribution may be provided due to improved blood flow. Alternatively the at least partial muscle contraction may provide massage effect for promoting movement of fibrous septae.
Simultaneous application of combined magnetic and optical treatment may reach more significant results than separate use of these treatments.
Simultaneous application of magnetic treatment and optical treatment may be administered in two modes: a first mode may generate the magnetic pulses while optical treatment is active or second mode may generate magnetic pulses while the optical treatment is not in an active stimulation period, i.e. the period of magnetic treatment and optical treatment alternates.
The simultaneous application of magnetic treatment and optical treatment to the target biological structure may increase the peak magnetic component of the entire treatment resulting in improved heating of the target biological structure containing higher water volume, e.g. skin. Alternatively, the level of polarization of the optical radiation may be increased due to magnetic field, or a plane of polarization may rotate, e.g. Faraday's effect may occur. Due to increased temperature of skin, the production and/or remodeling of collagen and/or elastin fibers may be improved and the skin may be provided with a younger, smoother and enhanced appearance. The effect of overheating the muscle is reduced by the improved blood flow.
Optical treatment may also be used to attenuate the pain. Alternatively the repetition rate of the magnetic treatment may attenuate pain as well.
Optical treatment may be applied after the magnetic treatment to provide contributing effect such as analgesic effect or it may further improve local metabolism. The magnetic treatment may induce at least partial muscle contraction or to stimulate a muscle structure to increase a muscular tonus of the target biological structure. Both effects may provide a massage effect for biological structures within the proximity of the target biological structure hence the blood and/or lymph circulation may be improved to promote local metabolism. The temperature may be locally increased by the improved blood flow and the target biological structure may accept the following optical treatment at significantly higher efficiency. Hence the muscle may be heated at higher quality. Additionally, the collagen and/or elastin fibers may be remodeled or restored and/or its neogenesis may be improved to provide a younger, smoother and enhanced skin appearance.
Additionally, previous application of magnetic treatment may improve acceptability of the optical treatment. The magnetic treatment may provide pain relieving effect for the biological structure hence the thermic effect caused by the optical treatment may be more tolerable for the patient.
Another benefit may be releasing the adipose cells from the muscle by at least partial muscle contraction and/or by temperature increase causing improved metabolism of adipose cells. Still another benefit of the at least partial muscle contraction may be mechanic breaking large adipose cells bulks into smaller bulks which may be easier removed by the lymphatic and/or blood flow. The liquidity of the smaller adipose bulks may be contributed by application of optical treatment. Due to improved liquidity, improved metabolism and/or blood circulation the cellulite may be treated in a short time and the visual effect on skin appearance may be significantly enhanced.
Optical radiation may be also used to attenuate the pain after the magnetic treatment.
Combined treatments may be applied to one target biological structure to provide combined effect of magnetic and optical treatment. Alternatively the treatment may be applied to different target biological structures, e.g. optical treatment may be applied to at least adipose cell and magnetic treatment may be applied to at least one muscle fiber to improve local and/or adipose cell metabolism.
All applications of combined magnetic and optical treatment may amplify the resulting effect of the treatment. Therefore the results are achieved in significantly shorter time than the same results achieved by separate applications of the optical and magnet treatments. The treatment may be provided in various predefined treatment protocols focused on specific patient's needs, e.g. cellulite treatment, incontinence treatment, pain relieving etc. Each treatment parameter may be adjusted in the treatment protocol by the operator following the patient's needs. Alternatively the specific treatment may be designed by the operator for providing the most effective treatment following the patient's needs.
A treatment device including a high frequency generator, a low frequency generator, a combiner and an energy deliver element; wherein the at least one energy delivery element provides an electromagnetic treatment and a magnetic treatment for treating a biological structure.
A treatment device including a least one high frequency generator, at least one low frequency generator, a plurality of combiners and a plurality of energy deliver elements; wherein the plurality of energy delivery elements provides an electromagnetic treatment and a magnetic treatment for treating a biological structure.
A method of operating a treatment device comprising: generating a high frequency signal; and generating a low frequency signal; and delivering the high frequency signal and/or the low frequency signal to an energy delivering element; and providing by the least one energy delivery element an electromagnetic and/or a magnetic treatment.
Magnetic stimulation device producing time-varying magnetic field for treatment, wherein device comprises: a connection to an energy source, a switch, a coil, an energy storage device, at least one blower and a casing; wherein the coil and the casing are arranged in a manner that fluid can flow in-between and wherein the coil is cooled by fluid flow over at least upper and lower sides of the coil.
A method of patient's neural structure stimulation by time-varying magnetic field inducing an action potential and/or modulating the action potential, including: exposing the patient to a time-varying magnetic field with a repetition rate which exceeds a repetition rate resolution of the target stimulated biological structure and wherein the time-varying magnetic field generates an envelope including at least two pulses.
A method of operating a magnetic stimulation device including at least one applicator, at least one energy source, a plurality of switching devices, at least one energy storage device and a plurality of magnetic field generating devices, comprising: generating a plurality of peaks of magnitudes of magnetic flux density using a plurality of magnetic field generating devices.
A treatment method for enhancing a visual appearance of a patient's body region comprising: applying a time-varying magnetic field to a target biological structure in the body region to induce electric current in the target biological structure, wherein the body region is at least one of thighs, saddlebags, buttocks, abdomen, hips, torso, arms, breast, neck, face or lip of the patient.
Thus, novel systems and methods have been described. Various changes and substitutions may of course be made without departing from the spirit and scope of the invention. The invention, therefore, should not be limited, except by the following claims and their equivalents.
The following U.S. Patent Applications are incorporated herein by reference: Ser. Nos. 14/873,110; 14/926,365; 14/951,093; 15/073,318; 15/099,274; 15/151,012; 15/178,455; 15/396,073; 15/446,951; 15/404,384 and 15/473,390.
Thus, novel apparatus and methods have been shown and described. Various changes and substitutions may of course be made without departing from the spirit and scope of the invention. The invention, therefore, should not be limited, except by the following claims and their equivalents.
This application is a continuation of U.S. patent application Ser. No. 17/752,316, filed May 24, 2022 and, which is a continuation of U.S. patent application Ser. No. 17/090,560, filed Nov. 5, 2020 and now patented as U.S. patent application Ser. No. 11/484,727, which is a continuation of U.S. patent application Ser. No. 16/827,330, filed Mar. 23, 2020 and now patented as U.S. Pat. No. 11,524,171, which is a continuation of U.S. patent application Ser. No. 15/601,719, filed May 22, 2017 and now patented as U.S. Pat. No. 10,596,386, which claims priority to each of U.S. Provisional Patent Application Nos. 62/357,679, filed Jul. 1, 2016, 62/440,905, filed Dec. 30, 2016, and 62/440,922, filed Dec. 30, 2016. Each of these applications is incorporated herein in its entirety by reference thereto.
| Number | Name | Date | Kind |
|---|---|---|---|
| 1050280 | Kruger | Jan 1913 | A |
| 1973387 | Neymann et al. | Sep 1934 | A |
| 2021676 | Wood et al. | Nov 1935 | A |
| 3163161 | Jacques et al. | Dec 1964 | A |
| 3566877 | Smith et al. | Mar 1971 | A |
| 3658051 | MacLean et al. | Apr 1972 | A |
| 3709228 | Barker | Jan 1973 | A |
| 3841306 | Hallgren et al. | Oct 1974 | A |
| 3915151 | Kraus | Oct 1975 | A |
| 3946349 | Haldeman, III | Mar 1976 | A |
| 3952751 | Yarger | Apr 1976 | A |
| 3971387 | Mantell | Jul 1976 | A |
| 4068292 | Berry et al. | Jan 1978 | A |
| 4143661 | LaForge et al. | Mar 1979 | A |
| 4197851 | Fellus | Apr 1980 | A |
| 4237898 | Whalley | Dec 1980 | A |
| 4261364 | Haddad et al. | Apr 1981 | A |
| 4305115 | Armitage | Dec 1981 | A |
| 4315503 | Ryaby et al. | Feb 1982 | A |
| 4392040 | Rand et al. | Jul 1983 | A |
| 4454883 | Fellus | Jun 1984 | A |
| 4456001 | Pescatore | Jun 1984 | A |
| 4550714 | Talish et al. | Nov 1985 | A |
| 4556056 | Fischer et al. | Dec 1985 | A |
| 4665898 | Costa et al. | May 1987 | A |
| 4674482 | Waltonen et al. | Jun 1987 | A |
| 4674505 | Pauli et al. | Jun 1987 | A |
| 4723536 | Rauscher et al. | Feb 1988 | A |
| 4850959 | Findl | Jul 1989 | A |
| 4889526 | Rauscher et al. | Dec 1989 | A |
| 4957480 | Morenings | Sep 1990 | A |
| 4989604 | Fang | Feb 1991 | A |
| 4993413 | McLeod et al. | Feb 1991 | A |
| 5061234 | Chaney | Oct 1991 | A |
| 5067940 | Liboff et al. | Nov 1991 | A |
| 5085626 | Frey | Feb 1992 | A |
| 5143063 | Fellner | Sep 1992 | A |
| 5156587 | Montone | Oct 1992 | A |
| 5181902 | Erickson et al. | Jan 1993 | A |
| 5199951 | Spears | Apr 1993 | A |
| 5246438 | Langberg | Sep 1993 | A |
| 5334181 | Rubinsky et al. | Aug 1994 | A |
| 5339217 | Cohen et al. | Aug 1994 | A |
| 5344384 | Ostrow et al. | Sep 1994 | A |
| 5401233 | Erickson et al. | Mar 1995 | A |
| 5415617 | Kraus | May 1995 | A |
| 5419344 | Dewitt | May 1995 | A |
| 5433737 | Aimone | Jul 1995 | A |
| 5433740 | Yamaguchi | Jul 1995 | A |
| 5562706 | Lauterbach et al. | Oct 1996 | A |
| 5584863 | Rauch et al. | Dec 1996 | A |
| 5620463 | Drolet | Apr 1997 | A |
| 5660836 | Knowlton | Aug 1997 | A |
| 5674218 | Rubinsky et al. | Oct 1997 | A |
| 5690692 | Fleming | Nov 1997 | A |
| 5691873 | Masaki | Nov 1997 | A |
| 5718662 | Jalinous | Feb 1998 | A |
| 5720773 | Lopez-Carlos et al. | Feb 1998 | A |
| 5725471 | Davey et al. | Mar 1998 | A |
| 5755753 | Knowlton | May 1998 | A |
| 5766124 | Polson | Jun 1998 | A |
| 5782743 | Russell | Jul 1998 | A |
| 5807232 | Espinoza et al. | Sep 1998 | A |
| 5857957 | Lin | Jan 1999 | A |
| 5908444 | Azure | Jun 1999 | A |
| 5919219 | Knowlton | Jul 1999 | A |
| 5968527 | Litovitz | Oct 1999 | A |
| 5984854 | Ishikawa et al. | Nov 1999 | A |
| 6017337 | Pira | Jan 2000 | A |
| 6032675 | Rubinsky | Mar 2000 | A |
| 6038485 | Axelgaard | Mar 2000 | A |
| 6047215 | McClure et al. | Apr 2000 | A |
| 6050994 | Mashall | Apr 2000 | A |
| 6063108 | Salansky et al. | May 2000 | A |
| 6067474 | Schulman et al. | May 2000 | A |
| 6086525 | Davey et al. | Jul 2000 | A |
| 6094599 | Bingham et al. | Jul 2000 | A |
| 6099459 | Jacobson | Aug 2000 | A |
| 6099523 | Kim et al. | Aug 2000 | A |
| 6117066 | Abrams et al. | Sep 2000 | A |
| 6132361 | Epstein et al. | Oct 2000 | A |
| 6141985 | Cluzeau et al. | Nov 2000 | A |
| 6155966 | Parker | Dec 2000 | A |
| 6161757 | Morris | Dec 2000 | A |
| 6179769 | Ishikawa et al. | Jan 2001 | B1 |
| 6179770 | Mould | Jan 2001 | B1 |
| 6179771 | Mueller | Jan 2001 | B1 |
| 6200259 | March | Mar 2001 | B1 |
| 6213933 | Lin | Apr 2001 | B1 |
| 6223750 | Ishikawa et al. | May 2001 | B1 |
| 6246905 | Mogul | Jun 2001 | B1 |
| 6255815 | Davey | Jul 2001 | B1 |
| 6261301 | Knesch et al. | Jul 2001 | B1 |
| 6273862 | Privitera et al. | Aug 2001 | B1 |
| 6273884 | Altshuler et al. | Aug 2001 | B1 |
| 6280376 | Holcomb | Aug 2001 | B1 |
| 6282448 | Katz et al. | Aug 2001 | B1 |
| D447806 | Davey et al. | Sep 2001 | S |
| 6311090 | Knowlton | Oct 2001 | B1 |
| 6324430 | Zarinetchi et al. | Nov 2001 | B1 |
| 6324432 | Rigaux et al. | Nov 2001 | B1 |
| 6334069 | George et al. | Dec 2001 | B1 |
| 6334074 | Spertell | Dec 2001 | B1 |
| 6350276 | Knowlton | Feb 2002 | B1 |
| 6366814 | Boveja et al. | Apr 2002 | B1 |
| 6402678 | Fischell et al. | Jun 2002 | B1 |
| 6413255 | Stern | Jul 2002 | B1 |
| 6418345 | Tepper et al. | Jul 2002 | B1 |
| 6424864 | Matsuura | Jul 2002 | B1 |
| 6425852 | Epstein et al. | Jul 2002 | B1 |
| 6443883 | Ostrow et al. | Sep 2002 | B1 |
| 6445955 | Michelson et al. | Sep 2002 | B1 |
| 6447440 | Markoll | Sep 2002 | B1 |
| 6453202 | Knowlton | Sep 2002 | B1 |
| 6461375 | Baudry et al. | Oct 2002 | B1 |
| 6491620 | Davey | Dec 2002 | B1 |
| 6500110 | Davey et al. | Dec 2002 | B1 |
| 6520903 | Yamashiro | Feb 2003 | B1 |
| 6527694 | Ishikawa et al. | Mar 2003 | B1 |
| 6527695 | Davey et al. | Mar 2003 | B1 |
| 6537197 | Ruohonen et al. | Mar 2003 | B1 |
| 6569078 | Ishikawa et al. | May 2003 | B2 |
| 6591138 | Fischell et al. | Jul 2003 | B1 |
| 6605080 | Altshuler et al. | Aug 2003 | B1 |
| 6635053 | Lalonde et al. | Oct 2003 | B1 |
| 6658301 | Loeb et al. | Dec 2003 | B2 |
| 6662054 | Kreindel et al. | Dec 2003 | B2 |
| 6663556 | Barker | Dec 2003 | B2 |
| 6663659 | McDaniel | Dec 2003 | B2 |
| 6701185 | Burnett et al. | Mar 2004 | B2 |
| 6702808 | Kreindel et al. | Mar 2004 | B1 |
| 6713733 | Kochman et al. | Mar 2004 | B2 |
| 6735481 | Bingham et al. | May 2004 | B1 |
| 6738667 | Deno et al. | May 2004 | B2 |
| 6749624 | Knowlton | Jun 2004 | B2 |
| 6827681 | Tanner et al. | Dec 2004 | B2 |
| 6849040 | Ruohonen et al. | Feb 2005 | B2 |
| 6860852 | Schonenberger et al. | Mar 2005 | B2 |
| 6871099 | Whitehurst et al. | Mar 2005 | B1 |
| 6879859 | Boveja | Apr 2005 | B1 |
| 6889090 | Kreindel | May 2005 | B2 |
| 6920883 | Bessette et al. | Jul 2005 | B2 |
| 6926660 | Miller | Aug 2005 | B2 |
| 6939287 | Ardizzone et al. | Sep 2005 | B1 |
| 6939344 | Kreindel | Sep 2005 | B2 |
| 6960202 | Cluzeau et al. | Nov 2005 | B2 |
| 6990427 | Kirsch et al. | Jan 2006 | B2 |
| 7008370 | Tanner et al. | Mar 2006 | B2 |
| 7024239 | George et al. | Apr 2006 | B2 |
| 7030764 | Smith et al. | Apr 2006 | B2 |
| 7041100 | Kreindel | May 2006 | B2 |
| 7083580 | Bernabei | Aug 2006 | B2 |
| 7104947 | Riehl | Sep 2006 | B2 |
| 7153256 | Riehl et al. | Dec 2006 | B2 |
| 7186209 | Jacobson et al. | Mar 2007 | B2 |
| 7211082 | Hall et al. | May 2007 | B2 |
| 7217265 | Hennings et al. | May 2007 | B2 |
| 7238183 | Kreindel | Jul 2007 | B2 |
| 7276020 | Becker et al. | Oct 2007 | B2 |
| 7276058 | Altshuler et al. | Oct 2007 | B2 |
| 7294101 | Fischell et al. | Nov 2007 | B2 |
| 7309309 | Wang et al. | Dec 2007 | B2 |
| 7318821 | Lalonde et al. | Jan 2008 | B2 |
| 7320664 | Riehl et al. | Jan 2008 | B2 |
| 7351252 | Altshuler et al. | Apr 2008 | B2 |
| 7367341 | Anderson | May 2008 | B2 |
| 7367936 | Myers et al. | May 2008 | B2 |
| 7369895 | Hurtado | May 2008 | B2 |
| 7372271 | Roozen | May 2008 | B2 |
| 7376460 | Bernabei | May 2008 | B2 |
| 7396326 | Ghiron et al. | Jul 2008 | B2 |
| 7407478 | Zangen et al. | Aug 2008 | B2 |
| 7494458 | Fischell et al. | Feb 2009 | B2 |
| 7496401 | Bernabei | Feb 2009 | B2 |
| 7520848 | Schneider et al. | Apr 2009 | B2 |
| 7520849 | Simon | Apr 2009 | B1 |
| 7520875 | Bernabei | Apr 2009 | B2 |
| 7532926 | Bernabei | May 2009 | B2 |
| 7560058 | Riehl et al. | Jul 2009 | B2 |
| 7571003 | Pozzato | Aug 2009 | B2 |
| 7591776 | Phillips et al. | Sep 2009 | B2 |
| 7601115 | Riehl | Oct 2009 | B2 |
| 7601116 | Fischell et al. | Oct 2009 | B2 |
| 7608035 | Farone | Oct 2009 | B2 |
| 7614996 | Riehl et al. | Nov 2009 | B2 |
| 7618429 | Mulholland | Nov 2009 | B2 |
| 7630774 | Karni et al. | Dec 2009 | B2 |
| 7643883 | Kreindel | Jan 2010 | B2 |
| 7651459 | Cameron et al. | Jan 2010 | B2 |
| 7697998 | Axelgaard | Apr 2010 | B2 |
| 7697999 | Axelgaard | Apr 2010 | B2 |
| 7699768 | Kishawi et al. | Apr 2010 | B2 |
| 7706885 | Farone | Apr 2010 | B2 |
| 7711431 | Tanner et al. | May 2010 | B2 |
| 7740574 | Pilla et al. | Jun 2010 | B2 |
| 7744523 | Epstein | Jun 2010 | B2 |
| 7753836 | Peterchev | Jul 2010 | B2 |
| 7783348 | Gill et al. | Aug 2010 | B2 |
| 7785358 | Lach | Aug 2010 | B2 |
| 7824324 | Riehl et al. | Nov 2010 | B2 |
| 7854232 | Aho et al. | Dec 2010 | B2 |
| 7854754 | Ting et al. | Dec 2010 | B2 |
| 7857746 | Riehl | Dec 2010 | B2 |
| 7857775 | Rosenberg et al. | Dec 2010 | B2 |
| 7901373 | Tavger | Mar 2011 | B2 |
| 7909786 | Bonnefin | Mar 2011 | B2 |
| 7914469 | Torbati | Mar 2011 | B2 |
| 7925066 | Ruohonen et al. | Apr 2011 | B2 |
| 7945321 | Bernabei | May 2011 | B2 |
| 7946973 | Peterchev | May 2011 | B2 |
| 7953500 | Bingham et al. | May 2011 | B2 |
| 7963903 | Ghiron et al. | Jun 2011 | B2 |
| 7976451 | Zangen et al. | Jul 2011 | B2 |
| 7981146 | Korb et al. | Jul 2011 | B2 |
| 7998053 | Aho | Aug 2011 | B2 |
| 8029432 | Dennis | Oct 2011 | B2 |
| 8035385 | Tomiha et al. | Oct 2011 | B2 |
| 8052591 | Mishelevich et al. | Nov 2011 | B2 |
| RE43007 | Lalonde et al. | Dec 2011 | E |
| 8088058 | Juliana et al. | Jan 2012 | B2 |
| 8105254 | Guantera et al. | Jan 2012 | B2 |
| 8118722 | Riehl et al. | Feb 2012 | B2 |
| 8128549 | Testani et al. | Mar 2012 | B2 |
| 8133191 | Rosenberg et al. | Mar 2012 | B2 |
| 8137258 | Dennis et al. | Mar 2012 | B1 |
| 8137259 | Dennis | Mar 2012 | B1 |
| 8170643 | Turner et al. | May 2012 | B2 |
| 8172835 | Leyh et al. | May 2012 | B2 |
| 8177702 | Riehl et al. | May 2012 | B2 |
| 8192474 | Levinson | Jun 2012 | B2 |
| 8204446 | Scheer et al. | Jun 2012 | B2 |
| 8246529 | Riehl et al. | Aug 2012 | B2 |
| 8251986 | Chornenky et al. | Aug 2012 | B2 |
| 8262556 | Fischell et al. | Sep 2012 | B2 |
| 8265763 | Fahey | Sep 2012 | B2 |
| 8265910 | Mishelevich et al. | Sep 2012 | B2 |
| 8267850 | Schneider et al. | Sep 2012 | B2 |
| 8271090 | Hartman et al. | Sep 2012 | B1 |
| 8275442 | Allison | Sep 2012 | B2 |
| 8277371 | Zangen et al. | Oct 2012 | B2 |
| 8285390 | Levinson et al. | Oct 2012 | B2 |
| 8303478 | Lebosse et al. | Nov 2012 | B2 |
| 8335566 | Muller et al. | Dec 2012 | B2 |
| 8337539 | Ting et al. | Dec 2012 | B2 |
| 8366756 | Tucek et al. | Feb 2013 | B2 |
| 8376825 | Guinn et al. | Feb 2013 | B2 |
| 8376925 | Dennis et al. | Feb 2013 | B1 |
| 8388510 | Zangen et al. | Mar 2013 | B2 |
| 8428735 | Littlewood et al. | Apr 2013 | B2 |
| 8454591 | Leyh et al. | Jun 2013 | B2 |
| 8457751 | Pozzato | Jun 2013 | B2 |
| 8465408 | Phillips et al. | Jun 2013 | B2 |
| 8475354 | Phillips et al. | Jul 2013 | B2 |
| 8480554 | Phillips et al. | Jul 2013 | B2 |
| 8493286 | Agrama | Jul 2013 | B1 |
| 8506468 | Ghiron et al. | Aug 2013 | B2 |
| 8517908 | Riehl et al. | Aug 2013 | B2 |
| 8523753 | Schneider et al. | Sep 2013 | B2 |
| 8523927 | Levinson et al. | Sep 2013 | B2 |
| 8548599 | Zarsky et al. | Oct 2013 | B2 |
| 8565888 | Buhlmann et al. | Oct 2013 | B2 |
| 8579953 | Dunbar et al. | Nov 2013 | B1 |
| 8585568 | Phillips et al. | Nov 2013 | B2 |
| 8585617 | Mashiach et al. | Nov 2013 | B2 |
| 8588930 | DiUbaldi et al. | Nov 2013 | B2 |
| 8593245 | Zeng et al. | Nov 2013 | B2 |
| 8603073 | Allison | Dec 2013 | B2 |
| 8608634 | Zangen et al. | Dec 2013 | B2 |
| 8641710 | Doty et al. | Feb 2014 | B2 |
| 8646239 | Rulon | Feb 2014 | B2 |
| 8657731 | Riehl et al. | Feb 2014 | B2 |
| 8666492 | Muller et al. | Mar 2014 | B2 |
| 8676338 | Levinson | Mar 2014 | B2 |
| 8684901 | Zabara | Apr 2014 | B1 |
| 8700176 | Azar et al. | Apr 2014 | B2 |
| 8702774 | Baker et al. | Apr 2014 | B2 |
| 8721572 | Linder et al. | May 2014 | B1 |
| 8723628 | Mishelevich et al. | May 2014 | B2 |
| 8725270 | Towe | May 2014 | B2 |
| 8740765 | Fischell et al. | Jun 2014 | B1 |
| 8768454 | Sham et al. | Jul 2014 | B2 |
| 8771163 | Zangen et al. | Jul 2014 | B2 |
| 8771326 | Myeong et al. | Jul 2014 | B2 |
| 8777831 | Aho | Jul 2014 | B2 |
| 8788044 | Sasha | Jul 2014 | B2 |
| 8788060 | Nebrigic et al. | Jul 2014 | B2 |
| 8795148 | Schneider et al. | Aug 2014 | B2 |
| 8801589 | Peterchev et al. | Aug 2014 | B2 |
| 8825166 | John | Sep 2014 | B2 |
| 8834547 | Anderson | Sep 2014 | B2 |
| 8840608 | Anderson et al. | Sep 2014 | B2 |
| 8845508 | Schneider et al. | Sep 2014 | B2 |
| 8864641 | Riehl et al. | Oct 2014 | B2 |
| 8868177 | Simon et al. | Oct 2014 | B2 |
| 8870737 | Phillips et al. | Oct 2014 | B2 |
| 8888672 | Phillips et al. | Nov 2014 | B2 |
| 8888673 | Phillips et al. | Nov 2014 | B2 |
| 8906009 | Nebrigic et al. | Dec 2014 | B2 |
| 8909342 | Lozano | Dec 2014 | B2 |
| 8915948 | Altshuler et al. | Dec 2014 | B2 |
| 8926490 | Phillips et al. | Jan 2015 | B2 |
| 8932338 | Lim et al. | Jan 2015 | B2 |
| 8956273 | Mishelevich et al. | Feb 2015 | B2 |
| 8956274 | Schneider et al. | Feb 2015 | B2 |
| 8961386 | Phillips et al. | Feb 2015 | B2 |
| 8979727 | Ron et al. | Mar 2015 | B2 |
| 8985331 | Guenter et al. | Mar 2015 | B2 |
| 8998791 | Ron Edoute et al. | Apr 2015 | B2 |
| 9002477 | Burnett | Apr 2015 | B2 |
| 9008793 | Cosman, Sr. et al. | Apr 2015 | B1 |
| 9015057 | Phillips et al. | Apr 2015 | B2 |
| 9028469 | Jones et al. | May 2015 | B2 |
| 9031659 | Campbell et al. | May 2015 | B2 |
| 9033861 | Fischell et al. | May 2015 | B2 |
| 9037247 | Simon et al. | May 2015 | B2 |
| 9044595 | Araya et al. | Jun 2015 | B2 |
| 9061128 | Hall et al. | Jun 2015 | B2 |
| 9067052 | Moses et al. | Jun 2015 | B2 |
| 9072891 | Rao | Jul 2015 | B1 |
| 9078634 | Gonzales et al. | Jul 2015 | B2 |
| 9089719 | Simon et al. | Jul 2015 | B2 |
| 9101524 | Aghion | Aug 2015 | B2 |
| 9132031 | Levinson et al. | Sep 2015 | B2 |
| 9144513 | Paulson | Sep 2015 | B2 |
| 9149650 | Shanks et al. | Oct 2015 | B2 |
| 9168096 | Kreindel | Oct 2015 | B2 |
| 9233207 | Polyakov et al. | Jan 2016 | B2 |
| 9233257 | Zabara | Jan 2016 | B1 |
| 9254395 | Shambayati | Feb 2016 | B1 |
| 9261574 | Boskamp et al. | Feb 2016 | B2 |
| 9265690 | Kriksunov et al. | Feb 2016 | B2 |
| 9308120 | Anderson et al. | Apr 2016 | B2 |
| 9314368 | Allison et al. | Apr 2016 | B2 |
| 9326910 | Eckhouse et al. | May 2016 | B2 |
| 9339641 | Rajguru et al. | May 2016 | B2 |
| 9358068 | Schomacker et al. | Jun 2016 | B2 |
| 9358149 | Anderson et al. | Jun 2016 | B2 |
| 9375345 | Levinson et al. | Jun 2016 | B2 |
| 9387339 | Sham et al. | Jul 2016 | B2 |
| 9398975 | Müller et al. | Jul 2016 | B2 |
| 9408745 | Levinson et al. | Aug 2016 | B2 |
| 9414759 | Lang et al. | Aug 2016 | B2 |
| 9433797 | Pilla et al. | Sep 2016 | B2 |
| 9439805 | Gonzales et al. | Sep 2016 | B2 |
| 9446258 | Schwarz | Sep 2016 | B1 |
| 9468774 | Zarsky et al. | Oct 2016 | B2 |
| 9526912 | Fischell et al. | Dec 2016 | B1 |
| 9532832 | Ron Edoute et al. | Jan 2017 | B2 |
| 9545523 | Nanda | Jan 2017 | B2 |
| 9550067 | Fischell et al. | Jan 2017 | B1 |
| 9561357 | Hall et al. | Feb 2017 | B2 |
| 9561384 | Fischell et al. | Feb 2017 | B1 |
| 9586048 | Ternes et al. | Mar 2017 | B2 |
| 9586057 | Ladman | Mar 2017 | B2 |
| 9596920 | Shalev et al. | Mar 2017 | B2 |
| 9597225 | Guerrieri | Mar 2017 | B1 |
| 9610429 | Harris et al. | Apr 2017 | B2 |
| 9610459 | Burnett et al. | Apr 2017 | B2 |
| 9615854 | Matsushita | Apr 2017 | B2 |
| 9636516 | Schwarz | May 2017 | B2 |
| 9636519 | Ladman | May 2017 | B2 |
| 9649220 | Anderson et al. | May 2017 | B2 |
| 9655770 | Levinson et al. | May 2017 | B2 |
| 9675800 | Li et al. | Jun 2017 | B2 |
| 9675815 | Fischell et al. | Jun 2017 | B1 |
| 9694194 | Ron Edoute et al. | Jul 2017 | B2 |
| 9707121 | Hyde et al. | Jul 2017 | B2 |
| 9713567 | Guantera et al. | Jul 2017 | B2 |
| 9724533 | Fischell et al. | Aug 2017 | B1 |
| 9737238 | Wright et al. | Aug 2017 | B2 |
| 9737434 | Allison | Aug 2017 | B2 |
| 9757584 | Burnett | Sep 2017 | B2 |
| 9782324 | Crunick et al. | Oct 2017 | B2 |
| 9814897 | Ron Edoute et al. | Nov 2017 | B2 |
| 9844460 | Weber et al. | Dec 2017 | B2 |
| 9844461 | Levinson et al. | Dec 2017 | B2 |
| 9849299 | Sham et al. | Dec 2017 | B2 |
| 9849302 | Fischell et al. | Dec 2017 | B1 |
| 9855166 | Anderson | Jan 2018 | B2 |
| 9861421 | O'Neil et al. | Jan 2018 | B2 |
| 9861520 | Baker et al. | Jan 2018 | B2 |
| 9867996 | Zarsky et al. | Jan 2018 | B2 |
| 9901743 | Ron Edoute et al. | Feb 2018 | B2 |
| 9919161 | Schwarz | Mar 2018 | B2 |
| 9937358 | Schwarz | Apr 2018 | B2 |
| 9962553 | Schwarz et al. | May 2018 | B2 |
| 9968797 | Sham et al. | May 2018 | B2 |
| 9974519 | Schwarz | May 2018 | B1 |
| 9974684 | Anderson | May 2018 | B2 |
| 9980765 | Avram et al. | May 2018 | B2 |
| 9981143 | Ron Edoute et al. | May 2018 | B2 |
| 9999780 | Weyh et al. | Jun 2018 | B2 |
| 10029112 | Fischell et al. | Jul 2018 | B1 |
| 10037867 | Godyak | Jul 2018 | B2 |
| 10039929 | Schwarz et al. | Aug 2018 | B1 |
| 10080906 | Schwarz | Sep 2018 | B2 |
| 10092346 | Levinson | Oct 2018 | B2 |
| 10111770 | Harris et al. | Oct 2018 | B2 |
| 10111774 | Gonzales et al. | Oct 2018 | B2 |
| 10124187 | Schwarz et al. | Nov 2018 | B2 |
| 10183172 | Ghiron et al. | Jan 2019 | B2 |
| 10195010 | Sanders | Feb 2019 | B2 |
| 10195427 | Kent et al. | Feb 2019 | B2 |
| 10195453 | Schwarz et al. | Feb 2019 | B2 |
| 10195454 | Yamashiro | Feb 2019 | B2 |
| 10195456 | Cabrerizo et al. | Feb 2019 | B2 |
| 10201380 | Debenedictis et al. | Feb 2019 | B2 |
| 10245439 | Schwarz et al. | Apr 2019 | B1 |
| 10271900 | Marchitto et al. | Apr 2019 | B2 |
| 10279185 | Meadows et al. | May 2019 | B2 |
| 10342988 | Midorikawa et al. | Jul 2019 | B2 |
| 10363419 | Simon et al. | Jul 2019 | B2 |
| 10413745 | Riehl | Sep 2019 | B2 |
| 10463869 | Ron Edoute et al. | Nov 2019 | B2 |
| 10471269 | Schwarz et al. | Nov 2019 | B1 |
| 10471271 | John | Nov 2019 | B1 |
| 10478588 | Walpole | Nov 2019 | B2 |
| 10478633 | Schwarz et al. | Nov 2019 | B2 |
| 10478634 | Schwarz et al. | Nov 2019 | B2 |
| 10493293 | Schwarz et al. | Dec 2019 | B2 |
| 10518098 | Hong et al. | Dec 2019 | B2 |
| 10549109 | Schwarz | Feb 2020 | B2 |
| 10549110 | Schwarz et al. | Feb 2020 | B1 |
| 10556121 | Gurfein | Feb 2020 | B2 |
| 10556122 | Schwarz et al. | Feb 2020 | B1 |
| 10569094 | Schwarz | Feb 2020 | B2 |
| 10569095 | Schwarz et al. | Feb 2020 | B1 |
| 10583287 | Schwarz | Mar 2020 | B2 |
| 10589117 | Fischell et al. | Mar 2020 | B1 |
| 10596366 | Sama | Mar 2020 | B2 |
| 10596386 | Schwarz et al. | Mar 2020 | B2 |
| 10610696 | Peled | Apr 2020 | B1 |
| 10632321 | Schwarz et al. | Apr 2020 | B2 |
| 10639490 | Simon et al. | May 2020 | B2 |
| 10661093 | Ron Edoute et al. | May 2020 | B2 |
| 10675819 | Li et al. | Jun 2020 | B2 |
| 10688310 | Schwarz et al. | Jun 2020 | B2 |
| 10695575 | Schwarz et al. | Jun 2020 | B1 |
| 10695576 | Schwarz et al. | Jun 2020 | B2 |
| 10709894 | Schwarz et al. | Jul 2020 | B2 |
| 10709895 | Schwarz et al. | Jul 2020 | B2 |
| 10773094 | Rzasa et al. | Sep 2020 | B1 |
| 10806943 | Sokolowski | Oct 2020 | B2 |
| 10821295 | Schwarz et al. | Nov 2020 | B1 |
| 10835418 | Darbandi et al. | Nov 2020 | B1 |
| 10849784 | Jurna et al. | Dec 2020 | B2 |
| 10898710 | Sanderford | Jan 2021 | B1 |
| 10946195 | Strohl | Mar 2021 | B2 |
| 11141219 | Schwarz | Oct 2021 | B1 |
| 11185690 | Schwarz | Nov 2021 | B2 |
| 11207540 | Zangen et al. | Dec 2021 | B2 |
| 11247039 | Schwarz et al. | Feb 2022 | B2 |
| 11420061 | Caparso et al. | Aug 2022 | B2 |
| 11478638 | Toong et al. | Oct 2022 | B2 |
| 11484263 | Leaper | Nov 2022 | B2 |
| 11484725 | Schwarz et al. | Nov 2022 | B2 |
| 11484727 | Schwarz | Nov 2022 | B2 |
| 11529514 | Bolea et al. | Dec 2022 | B2 |
| 11607556 | Schwarz | Mar 2023 | B2 |
| 11672999 | John | Jun 2023 | B1 |
| 11779767 | Sasha | Oct 2023 | B1 |
| 20010018547 | Mechlenburg | Aug 2001 | A1 |
| 20010031906 | Ishikawa et al. | Oct 2001 | A1 |
| 20020010414 | Coston et al. | Jan 2002 | A1 |
| 20020049483 | Knowlton | Apr 2002 | A1 |
| 20020082466 | Han | Jun 2002 | A1 |
| 20020103411 | Bailey et al. | Aug 2002 | A1 |
| 20020128686 | Minogue | Sep 2002 | A1 |
| 20020143365 | Herbst | Oct 2002 | A1 |
| 20020143373 | Courtnage et al. | Oct 2002 | A1 |
| 20020160436 | Markov et al. | Oct 2002 | A1 |
| 20020165590 | Crowe et al. | Nov 2002 | A1 |
| 20020193709 | Bolze et al. | Dec 2002 | A1 |
| 20030028072 | Fischell et al. | Feb 2003 | A1 |
| 20030032900 | Ella | Feb 2003 | A1 |
| 20030032950 | Altshuler et al. | Feb 2003 | A1 |
| 20030050527 | Fox et al. | Mar 2003 | A1 |
| 20030056281 | Hasegawa | Mar 2003 | A1 |
| 20030074037 | Moore et al. | Apr 2003 | A1 |
| 20030078646 | Axelgaard | Apr 2003 | A1 |
| 20030093133 | Crowe et al. | May 2003 | A1 |
| 20030130711 | Pearson et al. | Jul 2003 | A1 |
| 20030139789 | Tvinnereim et al. | Jul 2003 | A1 |
| 20030149451 | Chomenky et al. | Aug 2003 | A1 |
| 20030153958 | Yamazaki et al. | Aug 2003 | A1 |
| 20030158585 | Burnett | Aug 2003 | A1 |
| 20030216729 | Marchitto et al. | Nov 2003 | A1 |
| 20030220674 | Anderson et al. | Nov 2003 | A1 |
| 20030236487 | Knowlton | Dec 2003 | A1 |
| 20040015163 | Buysse et al. | Jan 2004 | A1 |
| 20040034346 | Stern et al. | Feb 2004 | A1 |
| 20040039279 | Ruohonen | Feb 2004 | A1 |
| 20040073079 | Altshuler et al. | Apr 2004 | A1 |
| 20040077977 | Ella et al. | Apr 2004 | A1 |
| 20040093042 | Altshuler et al. | May 2004 | A1 |
| 20040102768 | Cluzeau et al. | May 2004 | A1 |
| 20040162583 | Bingham et al. | Aug 2004 | A1 |
| 20040193000 | Riehl | Sep 2004 | A1 |
| 20040193003 | Mechlenburg | Sep 2004 | A1 |
| 20040206365 | Knowlton | Oct 2004 | A1 |
| 20040210214 | Knowlton | Oct 2004 | A1 |
| 20040210282 | Flock et al. | Oct 2004 | A1 |
| 20040210287 | Greene | Oct 2004 | A1 |
| 20040230226 | Bingham et al. | Nov 2004 | A1 |
| 20040260210 | Ella et al. | Dec 2004 | A1 |
| 20050004632 | Benedict | Jan 2005 | A1 |
| 20050038313 | Ardizzone | Feb 2005 | A1 |
| 20050049543 | Anderson et al. | Mar 2005 | A1 |
| 20050075701 | Shafer | Apr 2005 | A1 |
| 20050075702 | Shafer | Apr 2005 | A1 |
| 20050085866 | Tehrani | Apr 2005 | A1 |
| 20050085874 | Davis et al. | Apr 2005 | A1 |
| 20050090814 | Lalonde et al. | Apr 2005 | A1 |
| 20050107656 | Jang et al. | May 2005 | A1 |
| 20050134193 | Myers et al. | Jun 2005 | A1 |
| 20050177203 | Brighton et al. | Aug 2005 | A1 |
| 20050187599 | Sharkey et al. | Aug 2005 | A1 |
| 20050203504 | Wham et al. | Sep 2005 | A1 |
| 20050215987 | Slatkine | Sep 2005 | A1 |
| 20050216062 | Herbst | Sep 2005 | A1 |
| 20050228210 | Muntermann | Oct 2005 | A1 |
| 20050251120 | Anderson et al. | Nov 2005 | A1 |
| 20050251229 | Pilla et al. | Nov 2005 | A1 |
| 20060004244 | Phillips et al. | Jan 2006 | A1 |
| 20060020236 | Ben-Nun | Jan 2006 | A1 |
| 20060036300 | Kreindel | Feb 2006 | A1 |
| 20060064082 | Bonutti | Mar 2006 | A1 |
| 20060069420 | Rademacher et al. | Mar 2006 | A1 |
| 20060094924 | Riehl | May 2006 | A1 |
| 20060100550 | Schultheiss et al. | May 2006 | A1 |
| 20060100552 | Schultheiss et al. | May 2006 | A1 |
| 20060106375 | Werneth et al. | May 2006 | A1 |
| 20060152301 | Rohwedder | Jul 2006 | A1 |
| 20060184214 | McDaniel | Aug 2006 | A1 |
| 20060187607 | Mo | Aug 2006 | A1 |
| 20060195168 | Dunbar et al. | Aug 2006 | A1 |
| 20060199992 | Eisenberg et al. | Sep 2006 | A1 |
| 20060206103 | Altshuler et al. | Sep 2006 | A1 |
| 20060206180 | Alcidi | Sep 2006 | A1 |
| 20060229487 | Goodwin et al. | Oct 2006 | A1 |
| 20060253176 | Caruso et al. | Nov 2006 | A1 |
| 20060259102 | Slatkine | Nov 2006 | A1 |
| 20060271028 | Altshuler et al. | Nov 2006 | A1 |
| 20060287566 | Zangen et al. | Dec 2006 | A1 |
| 20060293719 | Naghavi | Dec 2006 | A1 |
| 20070010766 | Gil et al. | Jan 2007 | A1 |
| 20070010861 | Anderson et al. | Jan 2007 | A1 |
| 20070015951 | Culhane | Jan 2007 | A1 |
| 20070016274 | Boveja et al. | Jan 2007 | A1 |
| 20070027411 | Ella et al. | Feb 2007 | A1 |
| 20070083237 | Teruel | Apr 2007 | A1 |
| 20070088413 | Weber et al. | Apr 2007 | A1 |
| 20070088419 | Fiorina et al. | Apr 2007 | A1 |
| 20070100195 | Goodwin et al. | May 2007 | A1 |
| 20070135811 | Hooven | Jun 2007 | A1 |
| 20070142886 | Fischell et al. | Jun 2007 | A1 |
| 20070173749 | Williams et al. | Jul 2007 | A1 |
| 20070173805 | Weinberg et al. | Jul 2007 | A1 |
| 20070179534 | Firlik et al. | Aug 2007 | A1 |
| 20070198071 | Ting et al. | Aug 2007 | A1 |
| 20070232966 | Applebaum et al. | Oct 2007 | A1 |
| 20070239080 | Schaden et al. | Oct 2007 | A1 |
| 20070244530 | Ren | Oct 2007 | A1 |
| 20070255085 | Kishawi et al. | Nov 2007 | A1 |
| 20070255355 | Altshuler et al. | Nov 2007 | A1 |
| 20070255362 | Levinson et al. | Nov 2007 | A1 |
| 20070260107 | Mishelevich et al. | Nov 2007 | A1 |
| 20070270795 | Francischelli et al. | Nov 2007 | A1 |
| 20070270925 | Levinson | Nov 2007 | A1 |
| 20070282156 | Konings | Dec 2007 | A1 |
| 20070293911 | Crowe et al. | Dec 2007 | A1 |
| 20070293918 | Thompson et al. | Dec 2007 | A1 |
| 20080009885 | Del Giglio | Jan 2008 | A1 |
| 20080046053 | Wagner et al. | Feb 2008 | A1 |
| 20080077201 | Levinson et al. | Mar 2008 | A1 |
| 20080077202 | Levinson | Mar 2008 | A1 |
| 20080077211 | Levinson et al. | Mar 2008 | A1 |
| 20080082094 | McPherson et al. | Apr 2008 | A1 |
| 20080082153 | Gadsby et al. | Apr 2008 | A1 |
| 20080103565 | Altshuler et al. | May 2008 | A1 |
| 20080114199 | Riehl et al. | May 2008 | A1 |
| 20080114423 | Grenon et al. | May 2008 | A1 |
| 20080132971 | Pille et al. | Jun 2008 | A1 |
| 20080139871 | Muntermann | Jun 2008 | A1 |
| 20080146865 | Muntermann | Jun 2008 | A1 |
| 20080161636 | Hurme et al. | Jul 2008 | A1 |
| 20080167585 | Khen et al. | Jul 2008 | A1 |
| 20080177128 | Riehl et al. | Jul 2008 | A1 |
| 20080183251 | Azar et al. | Jul 2008 | A1 |
| 20080183252 | Khen | Jul 2008 | A1 |
| 20080188915 | Mills et al. | Aug 2008 | A1 |
| 20080195181 | Cole | Aug 2008 | A1 |
| 20080200749 | Zheng et al. | Aug 2008 | A1 |
| 20080200778 | Taskinen et al. | Aug 2008 | A1 |
| 20080228520 | Day et al. | Sep 2008 | A1 |
| 20080234534 | Mikas et al. | Sep 2008 | A1 |
| 20080234609 | Kreindel et al. | Sep 2008 | A1 |
| 20080249350 | Marchitto et al. | Oct 2008 | A1 |
| 20080255572 | Zeller et al. | Oct 2008 | A1 |
| 20080255637 | Oishi | Oct 2008 | A1 |
| 20080262287 | Dussau | Oct 2008 | A1 |
| 20080262574 | Briefs et al. | Oct 2008 | A1 |
| 20080275289 | Olree et al. | Nov 2008 | A1 |
| 20080287839 | Rosen et al. | Nov 2008 | A1 |
| 20080287948 | Newton et al. | Nov 2008 | A1 |
| 20080288035 | Gill et al. | Nov 2008 | A1 |
| 20080306325 | Burnett et al. | Dec 2008 | A1 |
| 20080306326 | Epstein | Dec 2008 | A1 |
| 20080312647 | Knopp et al. | Dec 2008 | A1 |
| 20090005631 | Simenhaus et al. | Jan 2009 | A1 |
| 20090018384 | Boyden et al. | Jan 2009 | A1 |
| 20090018623 | Levinson et al. | Jan 2009 | A1 |
| 20090018624 | Levinson et al. | Jan 2009 | A1 |
| 20090018625 | Levinson et al. | Jan 2009 | A1 |
| 20090018626 | Levinson et al. | Jan 2009 | A1 |
| 20090018627 | Levinson et al. | Jan 2009 | A1 |
| 20090018628 | Burns et al. | Jan 2009 | A1 |
| 20090024192 | Mulholland | Jan 2009 | A1 |
| 20090024193 | Altshuler et al. | Jan 2009 | A1 |
| 20090030352 | Schultheiss et al. | Jan 2009 | A1 |
| 20090036803 | Warlick et al. | Feb 2009 | A1 |
| 20090036958 | Mehta | Feb 2009 | A1 |
| 20090043185 | McAdams et al. | Feb 2009 | A1 |
| 20090043188 | Raischer | Feb 2009 | A1 |
| 20090043293 | Pankratov et al. | Feb 2009 | A1 |
| 20090062885 | Brighton et al. | Mar 2009 | A1 |
| 20090093740 | Helgeson et al. | Apr 2009 | A1 |
| 20090099405 | Schneider et al. | Apr 2009 | A1 |
| 20090108969 | Sims et al. | Apr 2009 | A1 |
| 20090118722 | Ebbers et al. | May 2009 | A1 |
| 20090118790 | Van Herk | May 2009 | A1 |
| 20090149300 | Chen | Jun 2009 | A1 |
| 20090149925 | MacDonald et al. | Jun 2009 | A1 |
| 20090149929 | Levinson et al. | Jun 2009 | A1 |
| 20090149930 | Schenck | Jun 2009 | A1 |
| 20090156958 | Mehta et al. | Jun 2009 | A1 |
| 20090163761 | Culhane | Jun 2009 | A1 |
| 20090198144 | Phillips et al. | Aug 2009 | A1 |
| 20090209840 | Axelgaard | Aug 2009 | A1 |
| 20090221938 | Rosenberg et al. | Sep 2009 | A1 |
| 20090227830 | Pillutla et al. | Sep 2009 | A1 |
| 20090227831 | Burnett et al. | Sep 2009 | A1 |
| 20090234423 | Vetanze | Sep 2009 | A1 |
| 20090240096 | Riehl et al. | Sep 2009 | A1 |
| 20090248004 | Altshuler et al. | Oct 2009 | A1 |
| 20090254007 | Schultheiss et al. | Oct 2009 | A1 |
| 20090254154 | De Taboada et al. | Oct 2009 | A1 |
| 20090270945 | Markoll | Oct 2009 | A1 |
| 20090281464 | Cioanta et al. | Nov 2009 | A1 |
| 20090284339 | Choi et al. | Nov 2009 | A1 |
| 20090306648 | Podhajsky et al. | Dec 2009 | A1 |
| 20090326528 | Karni et al. | Dec 2009 | A1 |
| 20090326571 | Mulholland | Dec 2009 | A1 |
| 20100004536 | Rosenberg | Jan 2010 | A1 |
| 20100004715 | Fahey | Jan 2010 | A1 |
| 20100016761 | Rosenberg | Jan 2010 | A1 |
| 20100016850 | Ron Edoute et al. | Jan 2010 | A1 |
| 20100030298 | Martens et al. | Feb 2010 | A1 |
| 20100036191 | Walter et al. | Feb 2010 | A1 |
| 20100036368 | England et al. | Feb 2010 | A1 |
| 20100049188 | Nelson et al. | Feb 2010 | A1 |
| 20100069704 | Peterchev | Mar 2010 | A1 |
| 20100081971 | Allison | Apr 2010 | A1 |
| 20100087699 | Peterchev | Apr 2010 | A1 |
| 20100087816 | Roy | Apr 2010 | A1 |
| 20100106064 | Kreindel et al. | Apr 2010 | A1 |
| 20100121131 | Mathes | May 2010 | A1 |
| 20100130945 | Laniado et al. | May 2010 | A1 |
| 20100137760 | Schulz et al. | Jun 2010 | A1 |
| 20100145399 | Johari et al. | Jun 2010 | A1 |
| 20100152522 | Roth et al. | Jun 2010 | A1 |
| 20100152824 | Allison | Jun 2010 | A1 |
| 20100160712 | Burnett et al. | Jun 2010 | A1 |
| 20100168501 | Burnett et al. | Jul 2010 | A1 |
| 20100179372 | Glassman | Jul 2010 | A1 |
| 20100179373 | Pille et al. | Jul 2010 | A1 |
| 20100185042 | Schneider et al. | Jul 2010 | A1 |
| 20100197993 | Vasishta | Aug 2010 | A1 |
| 20100210894 | Pascual-Leone et al. | Aug 2010 | A1 |
| 20100217253 | Mehta | Aug 2010 | A1 |
| 20100222629 | Burnett | Sep 2010 | A1 |
| 20100228075 | Lu | Sep 2010 | A1 |
| 20100228250 | Brogna | Sep 2010 | A1 |
| 20100256438 | Mishelevich et al. | Oct 2010 | A1 |
| 20100256439 | Schneider et al. | Oct 2010 | A1 |
| 20100261992 | Axelgaard | Oct 2010 | A1 |
| 20100274327 | Carroll et al. | Oct 2010 | A1 |
| 20100274329 | Bradley et al. | Oct 2010 | A1 |
| 20100280582 | Baker et al. | Nov 2010 | A1 |
| 20100286470 | Schneider et al. | Nov 2010 | A1 |
| 20100286691 | Kerr et al. | Nov 2010 | A1 |
| 20100298623 | Mishelevich et al. | Nov 2010 | A1 |
| 20100309689 | Coulson | Dec 2010 | A1 |
| 20100315225 | Teague | Dec 2010 | A1 |
| 20100324611 | Deming et al. | Dec 2010 | A1 |
| 20100331602 | Mishelevich et al. | Dec 2010 | A1 |
| 20100331603 | Szecsi | Dec 2010 | A1 |
| 20100331604 | Okamoto et al. | Dec 2010 | A1 |
| 20110004261 | Sham et al. | Jan 2011 | A1 |
| 20110007745 | Schultz et al. | Jan 2011 | A1 |
| 20110009737 | Manstein | Jan 2011 | A1 |
| 20110015464 | Riehl et al. | Jan 2011 | A1 |
| 20110021863 | Burnett et al. | Jan 2011 | A1 |
| 20110046432 | Simon et al. | Feb 2011 | A1 |
| 20110046523 | Altshuler et al. | Feb 2011 | A1 |
| 20110060179 | Aho et al. | Mar 2011 | A1 |
| 20110065976 | Chornenky et al. | Mar 2011 | A1 |
| 20110066216 | Ting et al. | Mar 2011 | A1 |
| 20110077451 | Marchitto et al. | Mar 2011 | A1 |
| 20110081333 | Shantha et al. | Apr 2011 | A1 |
| 20110082383 | Cory et al. | Apr 2011 | A1 |
| 20110087312 | Shanks et al. | Apr 2011 | A1 |
| 20110105826 | Mishelevich et al. | May 2011 | A1 |
| 20110112520 | Michael | May 2011 | A1 |
| 20110118722 | Lischinsky et al. | May 2011 | A1 |
| 20110125203 | Simon et al. | May 2011 | A1 |
| 20110125213 | Simon et al. | May 2011 | A1 |
| 20110130618 | Ron et al. | Jun 2011 | A1 |
| 20110130713 | Dufay | Jun 2011 | A1 |
| 20110130796 | Louise | Jun 2011 | A1 |
| 20110152967 | Simon et al. | Jun 2011 | A1 |
| 20110172735 | Johari | Jul 2011 | A1 |
| 20110172752 | Bingham et al. | Jul 2011 | A1 |
| 20110190569 | Simon et al. | Aug 2011 | A1 |
| 20110196438 | Mnozil et al. | Aug 2011 | A1 |
| 20110202058 | Eder et al. | Aug 2011 | A1 |
| 20110207988 | Ruohonen | Aug 2011 | A1 |
| 20110218464 | Iger | Sep 2011 | A1 |
| 20110224761 | Manstein | Sep 2011 | A1 |
| 20110237921 | Askin, III et al. | Sep 2011 | A1 |
| 20110238050 | Allison et al. | Sep 2011 | A1 |
| 20110238051 | Levinson et al. | Sep 2011 | A1 |
| 20110245900 | Turner et al. | Oct 2011 | A1 |
| 20110263925 | Bratton | Oct 2011 | A1 |
| 20110273251 | Mishelevich et al. | Nov 2011 | A1 |
| 20110275881 | Aho | Nov 2011 | A1 |
| 20110275927 | Wagner et al. | Nov 2011 | A1 |
| 20110276108 | Crowe et al. | Nov 2011 | A1 |
| 20110295160 | Hart | Dec 2011 | A1 |
| 20110300079 | Martens et al. | Dec 2011 | A1 |
| 20110306905 | Novak et al. | Dec 2011 | A1 |
| 20110306943 | Dunbar et al. | Dec 2011 | A1 |
| 20110319700 | Schneider | Dec 2011 | A1 |
| 20120016177 | Mishelevich et al. | Jan 2012 | A1 |
| 20120016359 | Podhajsky | Jan 2012 | A1 |
| 20120022518 | Levinson | Jan 2012 | A1 |
| 20120029264 | Roth et al. | Feb 2012 | A1 |
| 20120029394 | Babaev | Feb 2012 | A1 |
| 20120035608 | Marchitto | Feb 2012 | A1 |
| 20120046598 | Kardos et al. | Feb 2012 | A1 |
| 20120046653 | Welches et al. | Feb 2012 | A1 |
| 20120053449 | Moses et al. | Mar 2012 | A1 |
| 20120101326 | Simon et al. | Apr 2012 | A1 |
| 20120101366 | Ruohonen et al. | Apr 2012 | A1 |
| 20120108883 | Peterchev | May 2012 | A1 |
| 20120108884 | Bechler et al. | May 2012 | A1 |
| 20120109241 | Rauscher | May 2012 | A1 |
| 20120116271 | Caruso et al. | May 2012 | A1 |
| 20120150079 | Rosenberg | Jun 2012 | A1 |
| 20120157747 | Rybski et al. | Jun 2012 | A1 |
| 20120158100 | Schomacker | Jun 2012 | A1 |
| 20120172653 | Chornenky et al. | Jul 2012 | A1 |
| 20120191018 | Willeford | Jul 2012 | A1 |
| 20120195100 | Saitoh et al. | Aug 2012 | A1 |
| 20120197361 | Gonzales et al. | Aug 2012 | A1 |
| 20120203054 | Riehl et al. | Aug 2012 | A1 |
| 20120215210 | Brown et al. | Aug 2012 | A1 |
| 20120226272 | Chernov et al. | Sep 2012 | A1 |
| 20120226330 | Kolen et al. | Sep 2012 | A1 |
| 20120239120 | Karni et al. | Sep 2012 | A1 |
| 20120239123 | Weber et al. | Sep 2012 | A1 |
| 20120240940 | Paraschac et al. | Sep 2012 | A1 |
| 20120245483 | Lundqvist | Sep 2012 | A1 |
| 20120253098 | George et al. | Oct 2012 | A1 |
| 20120259382 | Trier et al. | Oct 2012 | A1 |
| 20120265111 | Glenzer et al. | Oct 2012 | A1 |
| 20120271206 | Shalev et al. | Oct 2012 | A1 |
| 20120271294 | Barthe et al. | Oct 2012 | A1 |
| 20120277587 | Adanny et al. | Nov 2012 | A1 |
| 20120302821 | Burnett | Nov 2012 | A1 |
| 20120303076 | Fahey | Nov 2012 | A1 |
| 20120310033 | Muntermann | Dec 2012 | A1 |
| 20120310035 | Schneider et al. | Dec 2012 | A1 |
| 20120310311 | Elkah | Dec 2012 | A1 |
| 20120323232 | Wolf et al. | Dec 2012 | A1 |
| 20120330090 | Sham et al. | Dec 2012 | A1 |
| 20130006039 | Sadler | Jan 2013 | A1 |
| 20130012755 | Slayton | Jan 2013 | A1 |
| 20130030239 | Weyh et al. | Jan 2013 | A1 |
| 20130035680 | Ben-Haim et al. | Feb 2013 | A1 |
| 20130035745 | Ahmed et al. | Feb 2013 | A1 |
| 20130053620 | Susedik | Feb 2013 | A1 |
| 20130066309 | Levinson | Mar 2013 | A1 |
| 20130072925 | Ben-Haim et al. | Mar 2013 | A1 |
| 20130072930 | Ben-Haim et al. | Mar 2013 | A1 |
| 20130079684 | Rosen et al. | Mar 2013 | A1 |
| 20130085317 | Feinstein | Apr 2013 | A1 |
| 20130096363 | Schneider et al. | Apr 2013 | A1 |
| 20130103127 | Mueller et al. | Apr 2013 | A1 |
| 20130116758 | Levinson et al. | May 2013 | A1 |
| 20130116759 | Levinson et al. | May 2013 | A1 |
| 20130123568 | Hamilton et al. | May 2013 | A1 |
| 20130123629 | Rosenberg et al. | May 2013 | A1 |
| 20130123764 | Zarsky et al. | May 2013 | A1 |
| 20130123765 | Zarsky et al. | May 2013 | A1 |
| 20130131764 | Grove | May 2013 | A1 |
| 20130137918 | Phillips et al. | May 2013 | A1 |
| 20130144106 | Phillips et al. | Jun 2013 | A1 |
| 20130144280 | Eckhouse et al. | Jun 2013 | A1 |
| 20130150651 | Phillips et al. | Jun 2013 | A1 |
| 20130150653 | Borsody | Jun 2013 | A1 |
| 20130158440 | Allison | Jun 2013 | A1 |
| 20130158634 | Ron et al. | Jun 2013 | A1 |
| 20130158636 | Ting et al. | Jun 2013 | A1 |
| 20130172959 | Azoulay | Jul 2013 | A1 |
| 20130178693 | Neuvonen et al. | Jul 2013 | A1 |
| 20130178764 | Eckhouse et al. | Jul 2013 | A1 |
| 20130184693 | Neev | Jul 2013 | A1 |
| 20130190744 | Avram et al. | Jul 2013 | A1 |
| 20130238043 | Beardall et al. | Sep 2013 | A1 |
| 20130238061 | Ron et al. | Sep 2013 | A1 |
| 20130238062 | Ron Edoute et al. | Sep 2013 | A1 |
| 20130245731 | Allison | Sep 2013 | A1 |
| 20130253384 | Anderson et al. | Sep 2013 | A1 |
| 20130253493 | Anderson et al. | Sep 2013 | A1 |
| 20130253494 | Anderson et al. | Sep 2013 | A1 |
| 20130253495 | Anderson et al. | Sep 2013 | A1 |
| 20130253496 | Anderson et al. | Sep 2013 | A1 |
| 20130261374 | Elder | Oct 2013 | A1 |
| 20130261683 | Soikum et al. | Oct 2013 | A1 |
| 20130267759 | Jin | Oct 2013 | A1 |
| 20130267760 | Jin | Oct 2013 | A1 |
| 20130267943 | Hancock | Oct 2013 | A1 |
| 20130289433 | Jin et al. | Oct 2013 | A1 |
| 20130303904 | Barthe et al. | Nov 2013 | A1 |
| 20130304159 | Simon et al. | Nov 2013 | A1 |
| 20130317281 | Schneider et al. | Nov 2013 | A1 |
| 20130317282 | Ron Edoute et al. | Nov 2013 | A1 |
| 20130331637 | Greff | Dec 2013 | A1 |
| 20130338424 | Pascual-Leone et al. | Dec 2013 | A1 |
| 20130338483 | Neuvonen et al. | Dec 2013 | A1 |
| 20140005645 | Ben-Haim et al. | Jan 2014 | A1 |
| 20140005758 | Ben-Yehuda et al. | Jan 2014 | A1 |
| 20140005759 | Fahey et al. | Jan 2014 | A1 |
| 20140005760 | Levinson et al. | Jan 2014 | A1 |
| 20140012064 | Riehl et al. | Jan 2014 | A1 |
| 20140018767 | Harris et al. | Jan 2014 | A1 |
| 20140025033 | Mirkov et al. | Jan 2014 | A1 |
| 20140025142 | Zarksy et al. | Jan 2014 | A1 |
| 20140046114 | Nishikawa et al. | Feb 2014 | A1 |
| 20140046232 | Sham et al. | Feb 2014 | A1 |
| 20140046339 | Bonutti | Feb 2014 | A1 |
| 20140046423 | Rajguru et al. | Feb 2014 | A1 |
| 20140052029 | Khen et al. | Feb 2014 | A1 |
| 20140066786 | Naghavi et al. | Mar 2014 | A1 |
| 20140067025 | Levinson et al. | Mar 2014 | A1 |
| 20140081069 | Tai | Mar 2014 | A1 |
| 20140081348 | Fischell | Mar 2014 | A1 |
| 20140081359 | Sand | Mar 2014 | A1 |
| 20140121446 | Phillips et al. | May 2014 | A1 |
| 20140135565 | Schneider | May 2014 | A9 |
| 20140148870 | Burnett | May 2014 | A1 |
| 20140179980 | Phillips et al. | Jun 2014 | A1 |
| 20140194958 | Chabal et al. | Jul 2014 | A1 |
| 20140200388 | Schneider et al. | Jul 2014 | A1 |
| 20140213844 | Pilla et al. | Jul 2014 | A1 |
| 20140221725 | Mishelevich et al. | Aug 2014 | A1 |
| 20140221990 | Kreindel | Aug 2014 | A1 |
| 20140228620 | Vasishta | Aug 2014 | A1 |
| 20140235926 | Zangen et al. | Aug 2014 | A1 |
| 20140235927 | Zangen et al. | Aug 2014 | A1 |
| 20140235928 | Zangen et al. | Aug 2014 | A1 |
| 20140235929 | Rohan | Aug 2014 | A1 |
| 20140243933 | Ginggen | Aug 2014 | A1 |
| 20140249352 | Zangen et al. | Sep 2014 | A1 |
| 20140249353 | Pesola et al. | Sep 2014 | A1 |
| 20140249355 | Martinez | Sep 2014 | A1 |
| 20140249601 | Bachinski et al. | Sep 2014 | A1 |
| 20140249609 | Zarsky et al. | Sep 2014 | A1 |
| 20140257071 | Curran et al. | Sep 2014 | A1 |
| 20140257145 | Emery et al. | Sep 2014 | A1 |
| 20140257443 | Baker et al. | Sep 2014 | A1 |
| 20140276248 | Hall et al. | Sep 2014 | A1 |
| 20140276693 | Altshuler et al. | Sep 2014 | A1 |
| 20140277219 | Nanda | Sep 2014 | A1 |
| 20140277302 | Weber et al. | Sep 2014 | A1 |
| 20140303425 | Pilla et al. | Oct 2014 | A1 |
| 20140303525 | Sitharaman | Oct 2014 | A1 |
| 20140303696 | Anderson et al. | Oct 2014 | A1 |
| 20140303697 | Anderson et al. | Oct 2014 | A1 |
| 20140309628 | Vaynberg et al. | Oct 2014 | A1 |
| 20140316188 | Peterchev et al. | Oct 2014 | A1 |
| 20140316310 | Ackermann et al. | Oct 2014 | A1 |
| 20140316393 | Levinson | Oct 2014 | A1 |
| 20140316485 | Ackermann et al. | Oct 2014 | A1 |
| 20140324120 | Bogie et al. | Oct 2014 | A1 |
| 20140330067 | Jordan | Nov 2014 | A1 |
| 20140336545 | Bonutti | Nov 2014 | A1 |
| 20140336721 | Simon et al. | Nov 2014 | A1 |
| 20140342428 | Goodwin et al. | Nov 2014 | A1 |
| 20140343351 | Tojo et al. | Nov 2014 | A1 |
| 20140350438 | Papirov et al. | Nov 2014 | A1 |
| 20140357935 | Ilmoniemi et al. | Dec 2014 | A1 |
| 20140364841 | Kornstein | Dec 2014 | A1 |
| 20140371515 | John | Dec 2014 | A1 |
| 20140371812 | Ackermann et al. | Dec 2014 | A1 |
| 20140378875 | Ron Edoute et al. | Dec 2014 | A1 |
| 20150005569 | Missoli | Jan 2015 | A1 |
| 20150005759 | Welches et al. | Jan 2015 | A1 |
| 20150018667 | Radman et al. | Jan 2015 | A1 |
| 20150018692 | Neuvonen et al. | Jan 2015 | A1 |
| 20150025299 | Ron et al. | Jan 2015 | A1 |
| 20150025545 | Grenon et al. | Jan 2015 | A1 |
| 20150038768 | Saitoh et al. | Feb 2015 | A1 |
| 20150080769 | Lotsch | Mar 2015 | A1 |
| 20150087888 | Hurme et al. | Mar 2015 | A1 |
| 20150088105 | Fatemi | Mar 2015 | A1 |
| 20150094788 | Pierenkemper | Apr 2015 | A1 |
| 20150112118 | Mishelevich et al. | Apr 2015 | A1 |
| 20150112412 | Anderson et al. | Apr 2015 | A1 |
| 20150119849 | Aronhalt et al. | Apr 2015 | A1 |
| 20150123661 | Yui et al. | May 2015 | A1 |
| 20150126914 | Crunick et al. | May 2015 | A1 |
| 20150127075 | Ward et al. | May 2015 | A1 |
| 20150133717 | Ghiron et al. | May 2015 | A1 |
| 20150133718 | Schneider et al. | May 2015 | A1 |
| 20150140633 | Vladila | May 2015 | A1 |
| 20150141877 | Feldman | May 2015 | A1 |
| 20150148858 | Kaib | May 2015 | A1 |
| 20150151137 | Hynninen et al. | Jun 2015 | A1 |
| 20150157873 | Sokolowski | Jun 2015 | A1 |
| 20150157874 | Aho et al. | Jun 2015 | A1 |
| 20150165226 | Simon et al. | Jun 2015 | A1 |
| 20150165232 | Altshuler | Jun 2015 | A1 |
| 20150165238 | Slayton et al. | Jun 2015 | A1 |
| 20150174002 | Burbank et al. | Jun 2015 | A1 |
| 20150190648 | Fischell et al. | Jul 2015 | A1 |
| 20150196772 | Ghiron et al. | Jul 2015 | A1 |
| 20150202454 | Burnett | Jul 2015 | A1 |
| 20150213724 | Shoshani | Jul 2015 | A1 |
| 20150216719 | Debenedictis | Aug 2015 | A1 |
| 20150216720 | Debenedictis | Aug 2015 | A1 |
| 20150216816 | O'Neil et al. | Aug 2015 | A1 |
| 20150217127 | Fischell et al. | Aug 2015 | A1 |
| 20150223975 | Anderson | Aug 2015 | A1 |
| 20150227680 | Mainkar et al. | Aug 2015 | A1 |
| 20150238248 | Thompson et al. | Aug 2015 | A1 |
| 20150238771 | Zarsk et al. | Aug 2015 | A1 |
| 20150246238 | Moses et al. | Sep 2015 | A1 |
| 20150265830 | Simon et al. | Sep 2015 | A1 |
| 20150265836 | Simon et al. | Sep 2015 | A1 |
| 20150272776 | Gonzales et al. | Oct 2015 | A1 |
| 20150283022 | Lee et al. | Oct 2015 | A1 |
| 20150283025 | Ledany | Oct 2015 | A1 |
| 20150297909 | Peashock | Oct 2015 | A1 |
| 20150314133 | Yamashiro | Nov 2015 | A1 |
| 20150328077 | Levinson | Nov 2015 | A1 |
| 20150328475 | Kim et al. | Nov 2015 | A1 |
| 20150342661 | Ron Edoute | Dec 2015 | A1 |
| 20150342780 | Levinson et al. | Dec 2015 | A1 |
| 20150360045 | Fischell et al. | Dec 2015 | A1 |
| 20150367141 | Goetz et al. | Dec 2015 | A1 |
| 20150375005 | Segal | Dec 2015 | A1 |
| 20160001092 | Solehmainen | Jan 2016 | A1 |
| 20160008619 | Pell et al. | Jan 2016 | A1 |
| 20160015588 | Tamiya et al. | Jan 2016 | A1 |
| 20160015995 | Leung et al. | Jan 2016 | A1 |
| 20160016013 | Capelli | Jan 2016 | A1 |
| 20160020070 | Kim et al. | Jan 2016 | A1 |
| 20160022349 | Woloszko et al. | Jan 2016 | A1 |
| 20160030763 | Midorikawa et al. | Feb 2016 | A1 |
| 20160038183 | Ignon et al. | Feb 2016 | A1 |
| 20160045755 | Chun et al. | Feb 2016 | A1 |
| 20160051401 | Yee et al. | Feb 2016 | A1 |
| 20160051827 | Ron et al. | Feb 2016 | A1 |
| 20160059027 | Zangen et al. | Mar 2016 | A1 |
| 20160066977 | Neal, II et al. | Mar 2016 | A1 |
| 20160066994 | Shanks | Mar 2016 | A1 |
| 20160067516 | Schneider et al. | Mar 2016 | A1 |
| 20160067517 | Burnett | Mar 2016 | A1 |
| 20160067518 | Mishelevich et al. | Mar 2016 | A1 |
| 20160082290 | Hart | Mar 2016 | A1 |
| 20160086458 | Biggs | Mar 2016 | A1 |
| 20160089550 | Debenedictis | Mar 2016 | A1 |
| 20160096032 | Schneider | Apr 2016 | A9 |
| 20160100977 | Lee et al. | Apr 2016 | A1 |
| 20160106982 | Cakmak et al. | Apr 2016 | A1 |
| 20160106994 | Crosby | Apr 2016 | A1 |
| 20160106995 | Järnefelt et al. | Apr 2016 | A1 |
| 20160114181 | Vaynberg et al. | Apr 2016 | A1 |
| 20160121112 | Azar | May 2016 | A1 |
| 20160121118 | Franke et al. | May 2016 | A1 |
| 20160129273 | Park | May 2016 | A1 |
| 20160129274 | Park | May 2016 | A1 |
| 20160136462 | Lewis, Jr. et al. | May 2016 | A1 |
| 20160150494 | Tabet et al. | May 2016 | A1 |
| 20160151637 | Abe et al. | Jun 2016 | A1 |
| 20160158548 | Ackermann et al. | Jun 2016 | A1 |
| 20160158571 | Goadsby | Jun 2016 | A1 |
| 20160158574 | Eckhouse et al. | Jun 2016 | A1 |
| 20160175193 | Jung | Jun 2016 | A1 |
| 20160175605 | Borsody | Jun 2016 | A1 |
| 20160184601 | Gleich et al. | Jun 2016 | A1 |
| 20160193006 | Azoulay | Jul 2016 | A1 |
| 20160193466 | Burnett | Jul 2016 | A1 |
| 20160206895 | Zangen et al. | Jul 2016 | A1 |
| 20160206896 | Zangen et al. | Jul 2016 | A1 |
| 20160213426 | Ben-Haim et al. | Jul 2016 | A1 |
| 20160213924 | Coleman et al. | Jul 2016 | A1 |
| 20160220834 | Schwarz | Aug 2016 | A1 |
| 20160220837 | Jin | Aug 2016 | A1 |
| 20160228698 | Horton et al. | Aug 2016 | A1 |
| 20160236004 | Fischell et al. | Aug 2016 | A1 |
| 20160243375 | Simon et al. | Aug 2016 | A1 |
| 20160243376 | Phillips | Aug 2016 | A1 |
| 20160250494 | Sakaki et al. | Sep 2016 | A1 |
| 20160256702 | Schwarz et al. | Sep 2016 | A1 |
| 20160256703 | Schwarz et al. | Sep 2016 | A1 |
| 20160270951 | Martins et al. | Sep 2016 | A1 |
| 20160303393 | Riehl et al. | Oct 2016 | A1 |
| 20160310756 | Boll et al. | Oct 2016 | A1 |
| 20160317346 | Kovach | Nov 2016 | A1 |
| 20160317827 | Schwarz et al. | Nov 2016 | A1 |
| 20160324684 | Levinson et al. | Nov 2016 | A1 |
| 20160338900 | Khen et al. | Nov 2016 | A1 |
| 20160339239 | Yoo et al. | Nov 2016 | A1 |
| 20160346561 | Ron Edoute et al. | Dec 2016 | A1 |
| 20160354035 | Reihl et al. | Dec 2016 | A1 |
| 20160354237 | Gonzales et al. | Dec 2016 | A1 |
| 20160361560 | Bean | Dec 2016 | A1 |
| 20160367795 | Ackermann et al. | Dec 2016 | A1 |
| 20170001024 | Prouza | Jan 2017 | A1 |
| 20170001025 | Schwarz et al. | Jan 2017 | A1 |
| 20170001026 | Schwarz et al. | Jan 2017 | A1 |
| 20170001027 | Ladman et al. | Jan 2017 | A1 |
| 20170001028 | Ladman et al. | Jan 2017 | A1 |
| 20170001029 | Pribula et al. | Jan 2017 | A1 |
| 20170001030 | Pribula et al. | Jan 2017 | A1 |
| 20170007309 | Debenedictis | Jan 2017 | A1 |
| 20170021188 | Lu | Jan 2017 | A1 |
| 20170027595 | Bonutti | Feb 2017 | A1 |
| 20170027596 | Bonutti | Feb 2017 | A1 |
| 20170028166 | Walpole et al. | Feb 2017 | A1 |
| 20170028212 | Roth et al. | Feb 2017 | A1 |
| 20170036019 | Matsushita | Feb 2017 | A1 |
| 20170043177 | Ron Edoute et al. | Feb 2017 | A1 |
| 20170049612 | Hussain et al. | Feb 2017 | A1 |
| 20170050019 | Ron Edoute et al. | Feb 2017 | A1 |
| 20170071790 | Grenon et al. | Mar 2017 | A1 |
| 20170072212 | Ladman et al. | Mar 2017 | A1 |
| 20170087009 | Badawi et al. | Mar 2017 | A1 |
| 20170087373 | Schwarz | Mar 2017 | A1 |
| 20170100585 | Hall et al. | Apr 2017 | A1 |
| 20170105869 | Frangineas, Jr. | Apr 2017 | A1 |
| 20170106201 | Schwarz et al. | Apr 2017 | A1 |
| 20170106203 | Schneider et al. | Apr 2017 | A1 |
| 20170113058 | Schneider | Apr 2017 | A1 |
| 20170120066 | Phillips et al. | May 2017 | A1 |
| 20170120067 | Prouza | May 2017 | A1 |
| 20170136254 | Simon et al. | May 2017 | A1 |
| 20170143958 | Shalev et al. | May 2017 | A1 |
| 20170151436 | Flaherty et al. | Jun 2017 | A1 |
| 20170151443 | Mishelevich et al. | Jun 2017 | A1 |
| 20170156907 | Harris et al. | Jun 2017 | A1 |
| 20170156973 | Hart | Jun 2017 | A1 |
| 20170157430 | Cheatham, III et al. | Jun 2017 | A1 |
| 20170165497 | Lu | Jun 2017 | A1 |
| 20170171666 | Biggs | Jun 2017 | A1 |
| 20170173347 | Schwarz et al. | Jun 2017 | A1 |
| 20170182334 | Altshuler et al. | Jun 2017 | A1 |
| 20170182335 | Altshuler et al. | Jun 2017 | A1 |
| 20170189703 | Lei | Jul 2017 | A1 |
| 20170189707 | Zabara | Jul 2017 | A1 |
| 20170196731 | Debenedictis et al. | Jul 2017 | A1 |
| 20170203117 | Biginton et al. | Jul 2017 | A1 |
| 20170209708 | Schwarz | Jul 2017 | A1 |
| 20170232267 | Riehl et al. | Aug 2017 | A1 |
| 20170239079 | Root et al. | Aug 2017 | A1 |
| 20170239467 | Shalev et al. | Aug 2017 | A1 |
| 20170259077 | Jin | Sep 2017 | A1 |
| 20170266460 | Upton et al. | Sep 2017 | A1 |
| 20170280889 | Koch | Oct 2017 | A1 |
| 20170290708 | Rapp | Oct 2017 | A1 |
| 20170291036 | Pell et al. | Oct 2017 | A1 |
| 20170296838 | Asahina et al. | Oct 2017 | A1 |
| 20170304614 | Yoo et al. | Oct 2017 | A1 |
| 20170304642 | Ron Edoute et al. | Oct 2017 | A1 |
| 20170312536 | Phillips et al. | Nov 2017 | A1 |
| 20170319378 | Anderson et al. | Nov 2017 | A1 |
| 20170325992 | Debenedictis et al. | Nov 2017 | A1 |
| 20170325993 | Jimenez et al. | Nov 2017 | A1 |
| 20170326042 | Zeng et al. | Nov 2017 | A1 |
| 20170326346 | Jimenez et al. | Nov 2017 | A1 |
| 20170326357 | Sacristan et al. | Nov 2017 | A1 |
| 20170326377 | Neuvonen et al. | Nov 2017 | A1 |
| 20170333705 | Schwarz | Nov 2017 | A1 |
| 20170333725 | Hotani | Nov 2017 | A1 |
| 20170340884 | Franke et al. | Nov 2017 | A1 |
| 20170340894 | Rohan | Nov 2017 | A1 |
| 20170348143 | Rosen et al. | Dec 2017 | A1 |
| 20170348539 | Schwarz et al. | Dec 2017 | A1 |
| 20170354530 | Shagdar et al. | Dec 2017 | A1 |
| 20170354818 | De Toni et al. | Dec 2017 | A1 |
| 20170361095 | Mueller et al. | Dec 2017 | A1 |
| 20170368332 | Ackermann et al. | Dec 2017 | A1 |
| 20170372006 | Mainkar et al. | Dec 2017 | A1 |
| 20180000347 | Perez et al. | Jan 2018 | A1 |
| 20180000533 | Boll et al. | Jan 2018 | A1 |
| 20180001106 | Schwarz | Jan 2018 | A1 |
| 20180001107 | Schwarz et al. | Jan 2018 | A1 |
| 20180021565 | Dar et al. | Jan 2018 | A1 |
| 20180028831 | Ron Edoute et al. | Feb 2018 | A1 |
| 20180036548 | Nusse | Feb 2018 | A1 |
| 20180043151 | Ejiri et al. | Feb 2018 | A1 |
| 20180056083 | Jin | Mar 2018 | A1 |
| 20180064575 | Vaynberg et al. | Mar 2018 | A1 |
| 20180064950 | Segal | Mar 2018 | A1 |
| 20180064952 | Zangen et al. | Mar 2018 | A1 |
| 20180071544 | Ghiron et al. | Mar 2018 | A1 |
| 20180071545 | Saitoh et al. | Mar 2018 | A1 |
| 20180103991 | Linhart et al. | Apr 2018 | A1 |
| 20180104484 | Ryaby et al. | Apr 2018 | A1 |
| 20180104504 | Jin | Apr 2018 | A1 |
| 20180116905 | Capelli et al. | May 2018 | A1 |
| 20180125416 | Schwarz et al. | May 2018 | A1 |
| 20180126184 | Phillips et al. | May 2018 | A1 |
| 20180133473 | Yoo et al. | May 2018 | A1 |
| 20180133498 | Chornenky et al. | May 2018 | A1 |
| 20180140860 | Ledany | May 2018 | A1 |
| 20180153736 | Mills et al. | Jun 2018 | A1 |
| 20180153760 | Rosen et al. | Jun 2018 | A1 |
| 20180154137 | Ackermann et al. | Jun 2018 | A1 |
| 20180154165 | Schneider | Jun 2018 | A1 |
| 20180154188 | Altshuler et al. | Jun 2018 | A1 |
| 20180161197 | Baker et al. | Jun 2018 | A1 |
| 20180171327 | Goodwin et al. | Jun 2018 | A1 |
| 20180177996 | Gozani et al. | Jun 2018 | A1 |
| 20180178026 | Riehl et al. | Jun 2018 | A1 |
| 20180185081 | O'Neil et al. | Jul 2018 | A1 |
| 20180185189 | Weber et al. | Jul 2018 | A1 |
| 20180200503 | Ryaby et al. | Jul 2018 | A1 |
| 20180214300 | Anderson et al. | Aug 2018 | A1 |
| 20180228646 | Gonzales et al. | Aug 2018 | A1 |
| 20180229048 | Sikora et al. | Aug 2018 | A1 |
| 20180229049 | Phillips et al. | Aug 2018 | A1 |
| 20180236254 | Schwarz et al. | Aug 2018 | A1 |
| 20180250056 | Avram et al. | Sep 2018 | A1 |
| 20180250521 | Wölfel et al. | Sep 2018 | A1 |
| 20180263677 | Hilton et al. | Sep 2018 | A1 |
| 20180264245 | Edwards et al. | Sep 2018 | A1 |
| 20180271767 | Jimenez et al. | Sep 2018 | A1 |
| 20180280711 | Sekino et al. | Oct 2018 | A1 |
| 20180289533 | Johnson et al. | Oct 2018 | A1 |
| 20180296831 | Matsushita | Oct 2018 | A1 |
| 20180304079 | Kim et al. | Oct 2018 | A1 |
| 20180310950 | Yee et al. | Nov 2018 | A1 |
| 20180318597 | Simon et al. | Nov 2018 | A1 |
| 20180325729 | Rynerson | Nov 2018 | A1 |
| 20180339151 | De Toni et al. | Nov 2018 | A1 |
| 20180345012 | Schwarz et al. | Dec 2018 | A1 |
| 20180345032 | Lu | Dec 2018 | A1 |
| 20180345833 | Gallagher et al. | Dec 2018 | A1 |
| 20180353767 | Biginton | Dec 2018 | A1 |
| 20180361154 | Levin | Dec 2018 | A1 |
| 20180369062 | Khen et al. | Dec 2018 | A1 |
| 20180369601 | Saitoh et al. | Dec 2018 | A1 |
| 20190000524 | Rosen et al. | Jan 2019 | A1 |
| 20190000529 | Kothare et al. | Jan 2019 | A1 |
| 20190000663 | Anderson et al. | Jan 2019 | A1 |
| 20190022392 | Franke et al. | Jan 2019 | A1 |
| 20190029876 | Anderson et al. | Jan 2019 | A1 |
| 20190030356 | Schwarz | Jan 2019 | A1 |
| 20190046810 | Carmeli et al. | Feb 2019 | A1 |
| 20190053870 | Azoulay | Feb 2019 | A1 |
| 20190053871 | Moosmann et al. | Feb 2019 | A1 |
| 20190053940 | Biser et al. | Feb 2019 | A1 |
| 20190053941 | Samson | Feb 2019 | A1 |
| 20190053967 | Moosmann et al. | Feb 2019 | A1 |
| 20190060659 | Ginhoux et al. | Feb 2019 | A1 |
| 20190070428 | Phillips et al. | Mar 2019 | A1 |
| 20190111255 | Errico et al. | Apr 2019 | A1 |
| 20190111273 | Ghiron et al. | Apr 2019 | A1 |
| 20190117965 | Iger et al. | Apr 2019 | A1 |
| 20190125477 | Azoulay | May 2019 | A1 |
| 20190126036 | Franco-Obregon | May 2019 | A1 |
| 20190126041 | Kerselaers | May 2019 | A1 |
| 20190134414 | Schwarz | May 2019 | A1 |
| 20190151655 | Hall et al. | May 2019 | A1 |
| 20190160286 | Yang et al. | May 2019 | A1 |
| 20190167978 | Ackermann et al. | Jun 2019 | A1 |
| 20190168012 | Biginton | Jun 2019 | A1 |
| 20190183562 | Widgerow | Jun 2019 | A1 |
| 20190192219 | Kreindel | Jun 2019 | A1 |
| 20190192853 | Kim et al. | Jun 2019 | A1 |
| 20190192872 | Schwarz et al. | Jun 2019 | A1 |
| 20190192873 | Schwarz et al. | Jun 2019 | A1 |
| 20190192874 | Shukla | Jun 2019 | A1 |
| 20190192875 | Schwarz et al. | Jun 2019 | A1 |
| 20190201280 | Bak | Jul 2019 | A1 |
| 20190201705 | Schwarz et al. | Jul 2019 | A1 |
| 20190201706 | Schwarz et al. | Jul 2019 | A1 |
| 20190206545 | Mainkar et al. | Jul 2019 | A1 |
| 20190209836 | Yakoub | Jul 2019 | A1 |
| 20190209856 | Segal | Jul 2019 | A1 |
| 20190217090 | Ryaby et al. | Jul 2019 | A1 |
| 20190224490 | Goadsby et al. | Jul 2019 | A1 |
| 20190247654 | Alyagon et al. | Aug 2019 | A1 |
| 20190255346 | Ghiron | Aug 2019 | A1 |
| 20190269909 | Gozani et al. | Sep 2019 | A1 |
| 20190269931 | Riehl et al. | Sep 2019 | A1 |
| 20190275320 | Kim et al. | Sep 2019 | A1 |
| 20190282804 | Ackermann et al. | Sep 2019 | A1 |
| 20190290925 | Gellman et al. | Sep 2019 | A1 |
| 20190290928 | Biginton | Sep 2019 | A1 |
| 20190299016 | Altman | Oct 2019 | A1 |
| 20190299018 | Chornenky et al. | Oct 2019 | A1 |
| 20190314629 | Kreindel | Oct 2019 | A1 |
| 20190314638 | Kreindel | Oct 2019 | A1 |
| 20190328478 | Schuele | Oct 2019 | A1 |
| 20190329065 | Gandel | Oct 2019 | A1 |
| 20190336783 | Sokolowski | Nov 2019 | A1 |
| 20190344091 | Fischer | Nov 2019 | A1 |
| 20190350646 | Kreindel | Nov 2019 | A1 |
| 20190358465 | Segal | Nov 2019 | A1 |
| 20190358466 | Leung et al. | Nov 2019 | A1 |
| 20190365462 | Casalino | Dec 2019 | A1 |
| 20190388697 | Pell et al. | Dec 2019 | A1 |
| 20190388698 | Schwarz et al. | Dec 2019 | A1 |
| 20200001103 | Schwarz et al. | Jan 2020 | A1 |
| 20200016422 | Ron Edoute et al. | Jan 2020 | A1 |
| 20200016423 | Ron Edoute et al. | Jan 2020 | A1 |
| 20200030622 | Weyh et al. | Jan 2020 | A1 |
| 20200037079 | Biggs | Jan 2020 | A1 |
| 20200037080 | Biggs | Jan 2020 | A1 |
| 20200038674 | John | Feb 2020 | A1 |
| 20200038675 | Neuvonen et al. | Feb 2020 | A1 |
| 20200054395 | Marchitto et al. | Feb 2020 | A1 |
| 20200054890 | Schwarz et al. | Feb 2020 | A1 |
| 20200061385 | Schwarz et al. | Feb 2020 | A1 |
| 20200061386 | Schwarz et al. | Feb 2020 | A1 |
| 20200078212 | See | Mar 2020 | A1 |
| 20200078599 | Chen et al. | Mar 2020 | A1 |
| 20200086134 | Johnson et al. | Mar 2020 | A1 |
| 20200086314 | Wang et al. | Mar 2020 | A1 |
| 20200093297 | Dennewald | Mar 2020 | A1 |
| 20200094066 | Heath | Mar 2020 | A1 |
| 20200100837 | Ben-Haim et al. | Apr 2020 | A1 |
| 20200100932 | Hermanson et al. | Apr 2020 | A1 |
| 20200101291 | Yakovlev et al. | Apr 2020 | A1 |
| 20200101308 | Ilmoniemi et al. | Apr 2020 | A1 |
| 20200108266 | Chou | Apr 2020 | A1 |
| 20200114160 | Blendermann | Apr 2020 | A1 |
| 20200121984 | Sama | Apr 2020 | A1 |
| 20200129759 | Schwarz | Apr 2020 | A1 |
| 20200138540 | Azoulay | May 2020 | A1 |
| 20200139148 | Schwarz et al. | May 2020 | A1 |
| 20200146881 | Linder et al. | May 2020 | A1 |
| 20200155221 | Marchitto et al. | May 2020 | A1 |
| 20200155866 | Lu | May 2020 | A1 |
| 20200163827 | Hart | May 2020 | A1 |
| 20200171297 | Kirson et al. | Jun 2020 | A1 |
| 20200197696 | Nagel et al. | Jun 2020 | A1 |
| 20200197717 | Ishikawa et al. | Jun 2020 | A1 |
| 20200206522 | Riehl et al. | Jul 2020 | A1 |
| 20200206524 | Katznelson et al. | Jul 2020 | A1 |
| 20200222069 | Bonutti | Jul 2020 | A1 |
| 20200222708 | Simon et al. | Jul 2020 | A1 |
| 20200230431 | Saitoh et al. | Jul 2020 | A1 |
| 20200237424 | Hunziker et al. | Jul 2020 | A1 |
| 20200238076 | Ackermann et al. | Jul 2020 | A1 |
| 20200238098 | Chornenky et al. | Jul 2020 | A1 |
| 20200246617 | Errico et al. | Aug 2020 | A1 |
| 20200251203 | Mainkar et al. | Aug 2020 | A1 |
| 20200269062 | Chou | Aug 2020 | A1 |
| 20200276435 | Ryaby et al. | Sep 2020 | A1 |
| 20200281642 | Kreindel | Sep 2020 | A1 |
| 20200289837 | Lowin et al. | Sep 2020 | A1 |
| 20200289838 | Schwarz et al. | Sep 2020 | A1 |
| 20200306554 | Ron Edoute et al. | Oct 2020 | A1 |
| 20200316379 | Yoo et al. | Oct 2020 | A1 |
| 20200323680 | Hussain et al. | Oct 2020 | A1 |
| 20200324133 | Schwarz et al. | Oct 2020 | A1 |
| 20200330782 | Zabara | Oct 2020 | A1 |
| 20200352633 | Treen et al. | Nov 2020 | A1 |
| 20200353244 | Yamazaki | Nov 2020 | A1 |
| 20200353273 | Zucco | Nov 2020 | A1 |
| 20200353274 | Ansari et al. | Nov 2020 | A1 |
| 20200360681 | Lay | Nov 2020 | A1 |
| 20200384281 | Jin | Dec 2020 | A1 |
| 20200398055 | Flaherty et al. | Dec 2020 | A1 |
| 20200398070 | Phillips et al. | Dec 2020 | A1 |
| 20200406050 | Casanova et al. | Dec 2020 | A1 |
| 20210001139 | Shukla | Jan 2021 | A1 |
| 20210007668 | Leaper | Jan 2021 | A1 |
| 20210008369 | Crosson | Jan 2021 | A1 |
| 20210008382 | Vaidya | Jan 2021 | A1 |
| 20210022914 | Badawi | Jan 2021 | A1 |
| 20210023364 | Shalev et al. | Jan 2021 | A1 |
| 20210031040 | Franke et al. | Feb 2021 | A1 |
| 20210038891 | Goldfarb | Feb 2021 | A1 |
| 20210038894 | Mowery et al. | Feb 2021 | A1 |
| 20210052216 | Badawi et al. | Feb 2021 | A1 |
| 20210052893 | Suri et al. | Feb 2021 | A1 |
| 20210052894 | Sanderford | Feb 2021 | A1 |
| 20210052911 | Fischer | Feb 2021 | A1 |
| 20210093858 | Thakkar et al. | Apr 2021 | A1 |
| 20210093880 | Zhong et al. | Apr 2021 | A1 |
| 20210106429 | Pacca | Apr 2021 | A1 |
| 20210106842 | Zangen et al. | Apr 2021 | A1 |
| 20210138232 | Paz et al. | May 2021 | A1 |
| 20210146119 | Prouza et al. | May 2021 | A1 |
| 20210146150 | Frangineas, Jr. et al. | May 2021 | A1 |
| 20210146151 | Phillips et al. | May 2021 | A1 |
| 20210162211 | Chase et al. | Jun 2021 | A1 |
| 20210169682 | Alvarez et al. | Jun 2021 | A1 |
| 20210170188 | Paulus | Jun 2021 | A1 |
| 20210178174 | Lowin et al. | Jun 2021 | A1 |
| 20210187278 | Lu | Jun 2021 | A1 |
| 20210196197 | Leaper | Jul 2021 | A1 |
| 20210196957 | Yakovlev et al. | Jul 2021 | A1 |
| 20210205131 | Grenon et al. | Jul 2021 | A1 |
| 20210205631 | Ghiron et al. | Jul 2021 | A1 |
| 20210212634 | Leaper | Jul 2021 | A1 |
| 20210213283 | Yoo et al. | Jul 2021 | A1 |
| 20210219062 | Biggs | Jul 2021 | A1 |
| 20210228898 | Ghiron | Jul 2021 | A1 |
| 20210235901 | Dennewald | Aug 2021 | A1 |
| 20210236809 | Ackermann et al. | Aug 2021 | A1 |
| 20210260369 | Steier | Aug 2021 | A1 |
| 20210260398 | Bilston et al. | Aug 2021 | A1 |
| 20210268299 | Casalino et al. | Sep 2021 | A1 |
| 20210268300 | Peled | Sep 2021 | A1 |
| 20210275747 | Sobel et al. | Sep 2021 | A1 |
| 20210275825 | Kreindel | Sep 2021 | A1 |
| 20210283395 | Kreindel | Sep 2021 | A1 |
| 20210283412 | Neuvonen et al. | Sep 2021 | A1 |
| 20210290969 | Shukla | Sep 2021 | A1 |
| 20210298817 | Schwarz et al. | Sep 2021 | A1 |
| 20210299420 | Sobel et al. | Sep 2021 | A1 |
| 20210299446 | Errico et al. | Sep 2021 | A1 |
| 20210330102 | Monico | Oct 2021 | A1 |
| 20210330987 | Sun et al. | Oct 2021 | A1 |
| 20210361938 | Gershonowitz | Nov 2021 | A1 |
| 20210361939 | Ronja | Nov 2021 | A1 |
| 20210361964 | Pargger et al. | Nov 2021 | A1 |
| 20210361965 | Yakobson | Nov 2021 | A1 |
| 20210361967 | Cohen et al. | Nov 2021 | A1 |
| 20210369381 | Azoulay | Dec 2021 | A1 |
| 20210386992 | Simon et al. | Dec 2021 | A1 |
| 20220001168 | Ko | Jan 2022 | A1 |
| 20220001175 | Ko | Jan 2022 | A1 |
| 20220003112 | Leach et al. | Jan 2022 | A1 |
| 20220008741 | Chornenky et al. | Jan 2022 | A1 |
| 20220015942 | Biser et al. | Jan 2022 | A1 |
| 20220016413 | John et al. | Jan 2022 | A1 |
| 20220023654 | Carmeli et al. | Jan 2022 | A1 |
| 20220031408 | Cai et al. | Feb 2022 | A1 |
| 20220032052 | Kent | Feb 2022 | A1 |
| 20220032079 | Riehl et al. | Feb 2022 | A1 |
| 20220036584 | Sun et al. | Feb 2022 | A1 |
| 20220037071 | Kim et al. | Feb 2022 | A1 |
| 20220079811 | Kleinman et al. | Mar 2022 | A1 |
| 20220080217 | Peterchev et al. | Mar 2022 | A1 |
| 20220096146 | Vaynberg et al. | Mar 2022 | A1 |
| 20220111223 | Taylor et al. | Apr 2022 | A1 |
| 20220125546 | Azoulay | Apr 2022 | A1 |
| 20220126095 | Rajguru et al. | Apr 2022 | A1 |
| 20220126109 | Katznelson et al. | Apr 2022 | A1 |
| 20220152379 | Frangineas, Jr. et al. | May 2022 | A1 |
| 20220152394 | Levin | May 2022 | A1 |
| 20220152409 | Frangineas, Jr. et al. | May 2022 | A1 |
| 20220161042 | Lu | May 2022 | A1 |
| 20220161043 | Phillips et al. | May 2022 | A1 |
| 20220161044 | Phillips et al. | May 2022 | A1 |
| 20220168136 | Badawi et al. | Jun 2022 | A1 |
| 20220168584 | Schwarz et al. | Jun 2022 | A1 |
| 20220176101 | Ryaby et al. | Jun 2022 | A1 |
| 20220176114 | Shalev | Jun 2022 | A1 |
| 20220176142 | Ghiron et al. | Jun 2022 | A1 |
| 20220176144 | Velasco et al. | Jun 2022 | A1 |
| 20220184379 | Lindenthaler et al. | Jun 2022 | A1 |
| 20220184389 | Shalev | Jun 2022 | A1 |
| 20220184409 | Schwarz et al. | Jun 2022 | A1 |
| 20220192580 | Toth et al. | Jun 2022 | A1 |
| 20220193437 | Leung et al. | Jun 2022 | A1 |
| 20220203112 | Iger et al. | Jun 2022 | A1 |
| 20220211573 | Capelli et al. | Jul 2022 | A1 |
| 20220212006 | Rondoni et al. | Jul 2022 | A1 |
| 20220226645 | Shalev | Jul 2022 | A1 |
| 20220226646 | Shalev | Jul 2022 | A1 |
| 20220226647 | Shalev | Jul 2022 | A1 |
| 20220226648 | Shalev | Jul 2022 | A1 |
| 20220226649 | Shalev | Jul 2022 | A1 |
| 20220226662 | Casalino et al. | Jul 2022 | A1 |
| 20220233851 | Shalev | Jul 2022 | A1 |
| 20220241107 | Kim | Aug 2022 | A1 |
| 20220241604 | Lee | Aug 2022 | A1 |
| 20220249836 | Schwarz et al. | Aug 2022 | A1 |
| 20220280785 | Rynerson | Sep 2022 | A1 |
| 20220280799 | Altman | Sep 2022 | A1 |
| 20220288409 | Järnefelt | Sep 2022 | A1 |
| 20220362570 | Pemberton | Nov 2022 | A1 |
| 20220370006 | Zieger | Nov 2022 | A1 |
| 20220370814 | Epshtein et al. | Nov 2022 | A1 |
| 20220370818 | Taylor et al. | Nov 2022 | A1 |
| 20220378359 | Simon et al. | Dec 2022 | A1 |
| 20220379114 | Kent | Dec 2022 | A1 |
| 20220395681 | Martinot | Dec 2022 | A1 |
| 20220401256 | Durand | Dec 2022 | A1 |
| 20230001181 | Paz et al. | Jan 2023 | A1 |
| 20230001224 | Shukla | Jan 2023 | A1 |
| 20230013787 | Sitt | Jan 2023 | A1 |
| 20230125236 | Sandell et al. | Apr 2023 | A1 |
| 20230128482 | Gayes et al. | Apr 2023 | A1 |
| 20230130856 | Sandell et al. | Apr 2023 | A1 |
| 20230148962 | Leaper | May 2023 | A1 |
| 20230165721 | Kleinman et al. | Jun 2023 | A1 |
| 20230191144 | Ko | Jun 2023 | A1 |
| 20230201589 | Schwarz | Jun 2023 | A1 |
| 20230201621 | Gries | Jun 2023 | A1 |
| 20230211171 | Gries | Jul 2023 | A1 |
| 20230211172 | Oliveros | Jul 2023 | A1 |
| 20230218915 | Casalino et al. | Jul 2023 | A1 |
| 20230240784 | Azoulay | Aug 2023 | A1 |
| 20230248989 | Gries | Aug 2023 | A1 |
| 20230285767 | Kim | Sep 2023 | A1 |
| 20230293354 | Rao et al. | Sep 2023 | A1 |
| 20230293901 | Yun | Sep 2023 | A1 |
| 20230293903 | Jarnefelt | Sep 2023 | A1 |
| 20230310878 | Yoon et al. | Oct 2023 | A1 |
| 20230355967 | Kishi et al. | Nov 2023 | A1 |
| 20230364413 | Romaniw et al. | Nov 2023 | A1 |
| 20230372724 | Casalino et al. | Nov 2023 | A1 |
| 20230381499 | Simon et al. | Nov 2023 | A1 |
| 20230381504 | Yoo et al. | Nov 2023 | A1 |
| 20230381507 | Errico et al. | Nov 2023 | A1 |
| 20230381530 | Kim | Nov 2023 | A1 |
| 20230398352 | Errico et al. | Dec 2023 | A1 |
| 20230405306 | Simon et al. | Dec 2023 | A1 |
| 20230405319 | Simon et al. | Dec 2023 | A1 |
| 20230414960 | Ghiron et al. | Dec 2023 | A1 |
| 20230414961 | Gries | Dec 2023 | A1 |
| 20240001110 | Ko | Jan 2024 | A1 |
| 20240001114 | Shalev | Jan 2024 | A1 |
| 20240009450 | Ko | Jan 2024 | A1 |
| 20240009476 | Krinke et al. | Jan 2024 | A1 |
| 20240024692 | Khan | Jan 2024 | A1 |
| 20240024693 | Gonzales | Jan 2024 | A1 |
| 20240042228 | Ghiron et al. | Feb 2024 | A1 |
| Number | Date | Country |
|---|---|---|
| 747678 | May 2002 | AU |
| 2011265424 | Jul 2014 | AU |
| 2012200610 | Jul 2014 | AU |
| 2012244313 | Nov 2014 | AU |
| 2014203094 | Jul 2015 | AU |
| 2013207657 | Nov 2015 | AU |
| PI 0701434 | Nov 2008 | BR |
| PI0812502 | Jun 2015 | BR |
| 2484880 | Apr 2006 | CA |
| 2845438 | May 2014 | CA |
| 2604112 | Jul 2016 | CA |
| 3019140 | Oct 2017 | CA |
| 3019410 | Oct 2017 | CA |
| 3023821 | Nov 2017 | CA |
| 714113 | Mar 2019 | CH |
| 86204070 | Sep 1987 | CN |
| 87203746 | Dec 1987 | CN |
| 87215926 | Jul 1988 | CN |
| 1026953 | Dec 1994 | CN |
| 1027958 | Mar 1995 | CN |
| 2192348 | Mar 1995 | CN |
| 1206975 | Jun 2005 | CN |
| 101234231 | Aug 2008 | CN |
| 101327358 | Dec 2008 | CN |
| 201906360 | Jul 2011 | CN |
| 102319141 | Jan 2012 | CN |
| 102711706 | Oct 2012 | CN |
| 102847231 | Jan 2013 | CN |
| 202637725 | Jan 2013 | CN |
| 203169831 | Sep 2013 | CN |
| 102319141 | Aug 2014 | CN |
| 106540375 | Mar 2017 | CN |
| 206613045 | Nov 2017 | CN |
| 107613914 | Jan 2018 | CN |
| 108882992 | Nov 2018 | CN |
| 109310516 | Feb 2019 | CN |
| 208511024 | Feb 2019 | CN |
| 109865196 | Jun 2019 | CN |
| 110180083 | Aug 2019 | CN |
| 209221337 | Aug 2019 | CN |
| 209221338 | Aug 2019 | CN |
| 110339480 | Oct 2019 | CN |
| 210770219 | Jun 2020 | CN |
| 211357457 | Aug 2020 | CN |
| 111728712 | Oct 2020 | CN |
| 111840804 | Oct 2020 | CN |
| 112023270 | Dec 2020 | CN |
| 112221015 | Jan 2021 | CN |
| 212416683 | Jan 2021 | CN |
| 112472506 | Mar 2021 | CN |
| 112582159 | Mar 2021 | CN |
| 212700107 | Mar 2021 | CN |
| 113041500 | Jun 2021 | CN |
| 213432603 | Jun 2021 | CN |
| 214099374 | Aug 2021 | CN |
| 113499542 | Oct 2021 | CN |
| 113647936 | Nov 2021 | CN |
| 215081635 | Dec 2021 | CN |
| 215084285 | Dec 2021 | CN |
| 215309722 | Dec 2021 | CN |
| 216091887 | Mar 2022 | CN |
| 216169399 | Apr 2022 | CN |
| 216986082 | Jul 2022 | CN |
| 217526108 | Oct 2022 | CN |
| 115364376 | Nov 2022 | CN |
| 217908621 | Nov 2022 | CN |
| 115454185 | Dec 2022 | CN |
| 217960287 | Dec 2022 | CN |
| 218129587 | Dec 2022 | CN |
| 115591124 | Jan 2023 | CN |
| 115639868 | Jan 2023 | CN |
| 115645737 | Jan 2023 | CN |
| 115645748 | Jan 2023 | CN |
| 116328189 | Jun 2023 | CN |
| 219462335 | Aug 2023 | CN |
| 718637 | Mar 1942 | DE |
| 1118902 | Dec 1961 | DE |
| 2748780 | May 1978 | DE |
| 3205048 | Aug 1983 | DE |
| 3340974 | May 1985 | DE |
| 3610474 | Oct 1986 | DE |
| 3825165 | Jan 1990 | DE |
| 3340974 | Jul 1994 | DE |
| 69318706 | Jan 1999 | DE |
| 10062050 | Apr 2002 | DE |
| 102004006192 | Sep 2005 | DE |
| 60033756 | Jun 2007 | DE |
| 202010005501 | Aug 2010 | DE |
| 102009023855 | Dec 2010 | DE |
| 102009050010 | May 2011 | DE |
| 102010004307 | Jul 2011 | DE |
| 102006024467 | Apr 2012 | DE |
| 102011014291 | Sep 2012 | DE |
| 102012220121 | Sep 2013 | DE |
| 102013211859 | Jul 2015 | DE |
| 102014001185 | Jul 2015 | DE |
| 102016116399 | Mar 2018 | DE |
| 202019100373 | Mar 2019 | DE |
| 102017125678 | May 2019 | DE |
| 202018106565 | Oct 2019 | DE |
| 202020100975 | Mar 2020 | DE |
| 202016008884 | Jul 2020 | DE |
| 102010014157 | Feb 2021 | DE |
| 0633008 | Mar 1999 | DK |
| 000494 | Aug 1999 | EA |
| 002087 | Dec 2001 | EA |
| 002179 | Feb 2002 | EA |
| 003851 | Oct 2003 | EA |
| 007347 | Aug 2006 | EA |
| 007975 | Feb 2007 | EA |
| 0048451 | Mar 1982 | EP |
| 0039206 | Oct 1984 | EP |
| 0209246 | Jan 1987 | EP |
| 0459101 | Dec 1991 | EP |
| 0459401 | Dec 1991 | EP |
| 0633008 | Jan 1995 | EP |
| 0788813 | Aug 1997 | EP |
| 0633008 | May 1998 | EP |
| 0692993 | Sep 1999 | EP |
| 1022034 | Jul 2000 | EP |
| 1916013 | Apr 2008 | EP |
| 1883447 | Sep 2009 | EP |
| 2124800 | Nov 2010 | EP |
| 1917935 | Jan 2011 | EP |
| 2308559 | Apr 2011 | EP |
| 2139560 | May 2012 | EP |
| 2461765 | Jun 2012 | EP |
| 2564895 | Mar 2013 | EP |
| 1863569 | May 2013 | EP |
| 2069014 | Jun 2013 | EP |
| 1850781 | Jul 2013 | EP |
| 2614807 | Jul 2013 | EP |
| 2676700 | Dec 2013 | EP |
| 2694159 | Feb 2014 | EP |
| 2749259 | Jul 2014 | EP |
| 2814445 | Dec 2014 | EP |
| 2856986 | Apr 2015 | EP |
| 2878336 | Jun 2015 | EP |
| 2564894 | Nov 2015 | EP |
| 3009167 | Apr 2016 | EP |
| 2501352 | Jul 2016 | EP |
| 3209246 | Aug 2017 | EP |
| 3342379 | Jul 2018 | EP |
| 3389532 | Oct 2018 | EP |
| 3434323 | Jan 2019 | EP |
| 3476433 | May 2019 | EP |
| 3479872 | May 2019 | EP |
| 3656442 | May 2020 | EP |
| 3666325 | Jun 2020 | EP |
| 3721939 | Oct 2020 | EP |
| 3744392 | Dec 2020 | EP |
| 3772362 | Feb 2021 | EP |
| 3988164 | Apr 2022 | EP |
| 3988165 | Apr 2022 | EP |
| 4046660 | Aug 2022 | EP |
| 2118925 | Oct 1998 | ES |
| 2300569 | Jun 2008 | ES |
| 2305698 | Nov 2008 | ES |
| 2359581 | May 2011 | ES |
| 2533145 | Apr 2015 | ES |
| 2533145 | Jul 2016 | ES |
| 2533145 | Oct 2018 | ES |
| 2970656 | Jun 2014 | FR |
| 3041881 | Apr 2017 | FR |
| 3061012 | Jun 2018 | FR |
| 3071395 | Mar 2019 | FR |
| 260116 | Oct 1926 | GB |
| 304587 | Mar 1930 | GB |
| 390500 | Apr 1933 | GB |
| 871672 | Jun 1961 | GB |
| 2188238 | Sep 1987 | GB |
| 2176009 | Dec 1989 | GB |
| 2261820 | Jun 1993 | GB |
| 2286660 | Aug 1995 | GB |
| 2395907 | Dec 2004 | GB |
| 2504984 | Feb 2014 | GB |
| 2521240 | Jun 2015 | GB |
| 2521609 | Jul 2015 | GB |
| 2549466 | Oct 2017 | GB |
| 2552004 | Jan 2018 | GB |
| 2552810 | Feb 2018 | GB |
| 2554043 | Mar 2018 | GB |
| 2555809 | May 2018 | GB |
| 2567872 | May 2019 | GB |
| 2568051 | May 2019 | GB |
| 2587392 | Mar 2021 | GB |
| 2591692 | Aug 2021 | GB |
| 2602603 | Jul 2022 | GB |
| 3027678 | Nov 1998 | GR |
| 1217550 | Mar 1990 | IT |
| RE20120010 | Aug 2013 | IT |
| UB20159823 | Jul 2017 | IT |
| S5541836 | Mar 1980 | JP |
| H 07135376 | May 1995 | JP |
| H 09276418 | Oct 1997 | JP |
| 2002513621 | May 2002 | JP |
| 2003085523 | Mar 2003 | JP |
| 2003305131 | Oct 2003 | JP |
| 2005245585 | Sep 2005 | JP |
| 2006130055 | May 2006 | JP |
| 4178762 | Nov 2008 | JP |
| 4324673 | Sep 2009 | JP |
| 2010504792 | Feb 2010 | JP |
| 2010063007 | Mar 2010 | JP |
| 2010207268 | Sep 2010 | JP |
| 2010533054 | Oct 2010 | JP |
| 2011194176 | Oct 2011 | JP |
| 4837723 | Dec 2011 | JP |
| 2013012285 | Jan 2013 | JP |
| 2013063285 | Apr 2013 | JP |
| 2013066597 | Apr 2013 | JP |
| 2013116271 | Jun 2013 | JP |
| 3192971 | Sep 2014 | JP |
| 2017070427 | Apr 2017 | JP |
| 2017518857 | Jul 2017 | JP |
| 2018501927 | Jan 2018 | JP |
| 2018018650 | Feb 2018 | JP |
| 2018187510 | Nov 2018 | JP |
| 20010095888 | Nov 2001 | KR |
| 200261417 | Mar 2002 | KR |
| 20030065126 | Aug 2003 | KR |
| 100484618 | Apr 2005 | KR |
| 100491988 | May 2005 | KR |
| 200407524 | Jan 2006 | KR |
| 100556230 | Mar 2006 | KR |
| 200410065 | Mar 2006 | KR |
| 100841596 | Jun 2008 | KR |
| 20090063618 | Jun 2009 | KR |
| 20090095143 | Sep 2009 | KR |
| 100936914 | Jan 2010 | KR |
| 20100026107 | Mar 2010 | KR |
| 101022244 | Mar 2011 | KR |
| 20110123831 | Nov 2011 | KR |
| 20120037011 | Apr 2012 | KR |
| 101233286 | Feb 2013 | KR |
| 101233287 | Feb 2013 | KR |
| 101275228 | Jun 2013 | KR |
| 20130072244 | Jul 2013 | KR |
| 101292289 | Aug 2013 | KR |
| 20130106977 | Oct 2013 | KR |
| 20130128391 | Nov 2013 | KR |
| 101413022 | Jul 2014 | KR |
| 101415141 | Jul 2014 | KR |
| 101447532 | Oct 2014 | KR |
| 101511444 | Apr 2015 | KR |
| 20150049386 | May 2015 | KR |
| 20150058102 | May 2015 | KR |
| 101539633 | Jul 2015 | KR |
| 20150079619 | Jul 2015 | KR |
| 20150106379 | Sep 2015 | KR |
| 101610762 | Apr 2016 | KR |
| 101650155 | Aug 2016 | KR |
| 101673182 | Nov 2016 | KR |
| 101702400 | Feb 2017 | KR |
| 20170090654 | Aug 2017 | KR |
| 20170107603 | Sep 2017 | KR |
| 101794269 | Nov 2017 | KR |
| 20180059114 | Jun 2018 | KR |
| 20180092020 | Aug 2018 | KR |
| 101941863 | Jan 2019 | KR |
| 20190005981 | Jan 2019 | KR |
| 101955542 | May 2019 | KR |
| 102000971 | Jul 2019 | KR |
| 20190001779 | Jul 2019 | KR |
| 102063730 | Jan 2020 | KR |
| 200491572 | May 2020 | KR |
| 20200000889 | May 2020 | KR |
| 20200052602 | May 2020 | KR |
| 20200056692 | May 2020 | KR |
| 20200056693 | May 2020 | KR |
| 20200056801 | May 2020 | KR |
| 20200056802 | May 2020 | KR |
| 20200057154 | May 2020 | KR |
| 102185926 | Dec 2020 | KR |
| 20210002973 | Jan 2021 | KR |
| 20210002974 | Jan 2021 | KR |
| 20210105758 | Aug 2021 | KR |
| 102315486 | Oct 2021 | KR |
| 20220012823 | Feb 2022 | KR |
| 20220012825 | Feb 2022 | KR |
| 20230045777 | Apr 2023 | KR |
| 20230046655 | Apr 2023 | KR |
| 20230064250 | May 2023 | KR |
| 20230094311 | Jun 2023 | KR |
| 20230094312 | Jun 2023 | KR |
| 20230094313 | Jun 2023 | KR |
| 20230134278 | Sep 2023 | KR |
| 20240012685 | Jan 2024 | KR |
| 20240013316 | Jan 2024 | KR |
| 2012012158 | Apr 2014 | MX |
| 7510644 | Mar 1977 | NL |
| 1037451 | May 2011 | NL |
| 2212909 | Sep 2003 | RU |
| 2226115 | Mar 2004 | RU |
| 2281128 | Aug 2006 | RU |
| 2373971 | Nov 2009 | RU |
| 2392979 | Jun 2010 | RU |
| 2395267 | Jul 2010 | RU |
| 2496532 | Oct 2013 | RU |
| 2529471 | Sep 2014 | RU |
| 2596053 | Aug 2016 | RU |
| 2637104 | Nov 2017 | RU |
| 2645923 | Feb 2018 | RU |
| 24921 | Aug 2016 | SI |
| 510797 | Nov 2002 | TW |
| 200423986 | Nov 2004 | TW |
| 201825045 | Jul 2018 | TW |
| WO-9312835 | Jul 1993 | WO |
| WO-9521655 | Aug 1995 | WO |
| WO-9527533 | Oct 1995 | WO |
| WO-9932191 | Jul 1999 | WO |
| WO-0013749 | Mar 2000 | WO |
| WO-0044346 | Aug 2000 | WO |
| WO-0107111 | Feb 2001 | WO |
| WO-0112089 | Feb 2001 | WO |
| WO 03013334 | Aug 2001 | WO |
| WO-0193797 | Dec 2001 | WO |
| WO-0225675 | Mar 2002 | WO |
| WO 0226147 | Apr 2002 | WO |
| WO 02096514 | Dec 2002 | WO |
| WO-03078596 | Sep 2003 | WO |
| WO 2003075820 | Sep 2003 | WO |
| WO 03079916 | Oct 2003 | WO |
| WO-03090863 | Nov 2003 | WO |
| WO-03103769 | Dec 2003 | WO |
| WO-2004078255 | Sep 2004 | WO |
| WO 2004080526 | Sep 2004 | WO |
| WO 2004080527 | Sep 2004 | WO |
| WO-2004087255 | Oct 2004 | WO |
| WO-2004095385 | Nov 2004 | WO |
| WO-2004095835 | Nov 2004 | WO |
| WO-2004096343 | Nov 2004 | WO |
| WO-2004108211 | Dec 2004 | WO |
| WO-2005032660 | Apr 2005 | WO |
| WO 2005044375 | May 2005 | WO |
| WO 2005049132 | Jun 2005 | WO |
| WO 2005061051 | Jul 2005 | WO |
| WO 2005065032 | Jul 2005 | WO |
| WO 2005102188 | Nov 2005 | WO |
| WO 2005105013 | Nov 2005 | WO |
| WO 2005107866 | Nov 2005 | WO |
| WO 2006034306 | Mar 2006 | WO |
| WO 2006050279 | May 2006 | WO |
| WO 2006061867 | Jun 2006 | WO |
| WO 2006077567 | Jul 2006 | WO |
| WO 2006077582 | Jul 2006 | WO |
| WO-2006115120 | Nov 2006 | WO |
| WO 2006116728 | Nov 2006 | WO |
| WO 2006133636 | Dec 2006 | WO |
| WO 2007005373 | Jan 2007 | WO |
| WO 2007011583 | Jan 2007 | WO |
| WO 2007051896 | May 2007 | WO |
| WO-2007096206 | Aug 2007 | WO |
| WO-2007140584 | Dec 2007 | WO |
| WO-2008012827 | Jan 2008 | WO |
| WO-2008049775 | May 2008 | WO |
| WO-2008060494 | May 2008 | WO |
| WO 2008063478 | May 2008 | WO |
| WO 2008085162 | Jul 2008 | WO |
| WO-2008109058 | Sep 2008 | WO |
| WO 2008124112 | Oct 2008 | WO |
| WO-2008127011 | Oct 2008 | WO |
| WO-2008145260 | Dec 2008 | WO |
| WO-2009011708 | Jan 2009 | WO |
| WO-2009013729 | Jan 2009 | WO |
| WO-2009036040 | Mar 2009 | WO |
| WO-2009042863 | Apr 2009 | WO |
| WO-2009044400 | Apr 2009 | WO |
| WO 2009045358 | Apr 2009 | WO |
| WO-2009047628 | Apr 2009 | WO |
| WO-2009083915 | Jul 2009 | WO |
| WO 2009127840 | Oct 2009 | WO |
| WO-2010007614 | Jan 2010 | WO |
| WO-2010022278 | Feb 2010 | WO |
| WO-2010007614 | May 2010 | WO |
| WO 2010095147 | Aug 2010 | WO |
| WO 2010129997 | Nov 2010 | WO |
| WO-2010135425 | Nov 2010 | WO |
| WO 2010151619 | Dec 2010 | WO |
| WO-2010139376 | Dec 2010 | WO |
| WO-2011011749 | Jan 2011 | WO |
| WO-2011016019 | Feb 2011 | WO |
| WO-2011021184 | Feb 2011 | WO |
| WO-2011045002 | Apr 2011 | WO |
| WO-2011053607 | May 2011 | WO |
| WO 2011058556 | May 2011 | WO |
| WO-2011058565 | May 2011 | WO |
| WO 2011085020 | Jul 2011 | WO |
| WO 2011137262 | Nov 2011 | WO |
| WO-2011156495 | Dec 2011 | WO |
| WO-2012005766 | Jan 2012 | WO |
| WO 2012024169 | Feb 2012 | WO |
| WO-2012029065 | Mar 2012 | WO |
| WO 2012033932 | Mar 2012 | WO |
| WO-2012040243 | Mar 2012 | WO |
| WO-2012073232 | Jun 2012 | WO |
| WO 2012102837 | Aug 2012 | WO |
| WO-2012103632 | Aug 2012 | WO |
| WO 2012106735 | Aug 2012 | WO |
| WO-2012119293 | Sep 2012 | WO |
| WO-2012138169 | Oct 2012 | WO |
| WO-2013021380 | Feb 2013 | WO |
| WO-2013026393 | Feb 2013 | WO |
| WO-2013035088 | Mar 2013 | WO |
| WO-2013074576 | May 2013 | WO |
| WO 2012033932 | Jul 2013 | WO |
| WO-2013098815 | Jul 2013 | WO |
| WO 2013121265 | Aug 2013 | WO |
| WO 2013131639 | Sep 2013 | WO |
| WO-2013191699 | Dec 2013 | WO |
| WO 2014004051 | Jan 2014 | WO |
| WO-2014009875 | Jan 2014 | WO |
| WO-2014016820 | Jan 2014 | WO |
| WO 2014031857 | Feb 2014 | WO |
| WO 2014049501 | Apr 2014 | WO |
| WO-2014109653 | Jul 2014 | WO |
| WO-2014137344 | Sep 2014 | WO |
| WO-2014141229 | Sep 2014 | WO |
| WO-2014149021 | Sep 2014 | WO |
| WO-2014151431 | Sep 2014 | WO |
| WO-2014163020 | Oct 2014 | WO |
| WO-2014164926 | Oct 2014 | WO |
| WO 2014170887 | Oct 2014 | WO |
| WO 2014176420 | Oct 2014 | WO |
| WO-2015004540 | Jan 2015 | WO |
| WO-2015012639 | Jan 2015 | WO |
| WO-2015012672 | Jan 2015 | WO |
| WO 2015040049 | Mar 2015 | WO |
| WO-2015052705 | Apr 2015 | WO |
| WO-2015083305 | Jun 2015 | WO |
| WO 2015104454 | Jul 2015 | WO |
| WO 2015114629 | Aug 2015 | WO |
| WO-2015137733 | Sep 2015 | WO |
| WO 2015155545 | Oct 2015 | WO |
| WO-2015157725 | Oct 2015 | WO |
| WO 2015170184 | Nov 2015 | WO |
| WO-2015179571 | Nov 2015 | WO |
| WO 2015196164 | Dec 2015 | WO |
| WO 2016005719 | Jan 2016 | WO |
| WO 2016049284 | Mar 2016 | WO |
| WO 2016059556 | Apr 2016 | WO |
| WO-2016116747 | Jul 2016 | WO |
| WO 2016137319 | Sep 2016 | WO |
| WO-2016140871 | Sep 2016 | WO |
| WO 2016183307 | Nov 2016 | WO |
| WO 2016183689 | Nov 2016 | WO |
| WO-2017002065 | Jan 2017 | WO |
| WO 2017055471 | Apr 2017 | WO |
| WO 2017066620 | Apr 2017 | WO |
| WO 2017106878 | Jun 2017 | WO |
| WO-2017103923 | Jun 2017 | WO |
| WO 2017153840 | Sep 2017 | WO |
| WO-2017159959 | Sep 2017 | WO |
| WO-2017160097 | Sep 2017 | WO |
| WO-2017176621 | Oct 2017 | WO |
| WO 2017189890 | Nov 2017 | WO |
| WO 2017191624 | Nov 2017 | WO |
| WO-2017196548 | Nov 2017 | WO |
| WO-2017212253 | Dec 2017 | WO |
| WO 2017212258 | Dec 2017 | WO |
| WO-2018006086 | Jan 2018 | WO |
| WO-2018008023 | Jan 2018 | WO |
| WO 2018044054 | Mar 2018 | WO |
| WO-2018044825 | Mar 2018 | WO |
| WO 2018047164 | Mar 2018 | WO |
| WO 2018052958 | Mar 2018 | WO |
| WO 2018075394 | Apr 2018 | WO |
| WO 2018075514 | Apr 2018 | WO |
| WO 2018098417 | May 2018 | WO |
| WO-2018121998 | Jul 2018 | WO |
| WO-2018122535 | Jul 2018 | WO |
| WO 2018132678 | Jul 2018 | WO |
| WO-2017160097 | Sep 2018 | WO |
| WO-2018208992 | Nov 2018 | WO |
| WO 2018221903 | Dec 2018 | WO |
| WO 2018235629 | Dec 2018 | WO |
| WO 2019021288 | Jan 2019 | WO |
| WO 2019083863 | May 2019 | WO |
| WO 2019099068 | May 2019 | WO |
| WO 2019111053 | Jun 2019 | WO |
| WO 2019117740 | Jun 2019 | WO |
| WO 2019118709 | Jun 2019 | WO |
| WO-2019120420 | Jun 2019 | WO |
| WO 2019126792 | Jun 2019 | WO |
| WO 2019142196 | Jul 2019 | WO |
| WO 2019144316 | Aug 2019 | WO |
| WO 2019145762 | Aug 2019 | WO |
| WO-2019150378 | Aug 2019 | WO |
| WO 2019154834 | Aug 2019 | WO |
| WO 2019154837 | Aug 2019 | WO |
| WO 2019154839 | Aug 2019 | WO |
| WO 2019164471 | Aug 2019 | WO |
| WO-2019166965 | Sep 2019 | WO |
| WO-2019173866 | Sep 2019 | WO |
| WO-2019183622 | Sep 2019 | WO |
| WO 2019193000 | Oct 2019 | WO |
| WO 2019212972 | Nov 2019 | WO |
| WO-2020002801 | Jan 2020 | WO |
| WO-2020035852 | Feb 2020 | WO |
| WO-2020041502 | Feb 2020 | WO |
| WO 2020041633 | Feb 2020 | WO |
| WO 2020044331 | Mar 2020 | WO |
| WO 2020053848 | Mar 2020 | WO |
| WO 2020065651 | Apr 2020 | WO |
| WO 2020072243 | Apr 2020 | WO |
| WO 2020092653 | May 2020 | WO |
| WO-2020142470 | Jul 2020 | WO |
| WO-2020144486 | Jul 2020 | WO |
| WO-2020174444 | Sep 2020 | WO |
| WO-2020183508 | Sep 2020 | WO |
| WO-2020190514 | Sep 2020 | WO |
| WO 2020194278 | Oct 2020 | WO |
| WO-2020208590 | Oct 2020 | WO |
| WO 2020227288 | Nov 2020 | WO |
| WO 2020251177 | Dec 2020 | WO |
| WO-2020264263 | Dec 2020 | WO |
| WO 2019183306 | Jan 2021 | WO |
| WO 2021003473 | Jan 2021 | WO |
| WO-2021013654 | Jan 2021 | WO |
| WO 2012052986 | Apr 2021 | WO |
| WO-2021102365 | May 2021 | WO |
| WO 2021232096 | Nov 2021 | WO |
| WO 2022019695 | Jan 2022 | WO |
| WO 2022019696 | Jan 2022 | WO |
| WO 2022041657 | Mar 2022 | WO |
| WO 2022065800 | Mar 2022 | WO |
| WO 2022085989 | Apr 2022 | WO |
| WO 2022099067 | May 2022 | WO |
| WO 2022118028 | Jun 2022 | WO |
| WO 2022119577 | Jun 2022 | WO |
| WO 2022122923 | Jun 2022 | WO |
| WO 2022128991 | Jun 2022 | WO |
| WO 2022144555 | Jul 2022 | WO |
| WO 2022171218 | Aug 2022 | WO |
| WO 2022182756 | Sep 2022 | WO |
| WO 2022197674 | Sep 2022 | WO |
| WO 2022246320 | Nov 2022 | WO |
| WO 2022256388 | Dec 2022 | WO |
| WO 2023003501 | Jan 2023 | WO |
| WO 2023281448 | Jan 2023 | WO |
| WO 2023010656 | Feb 2023 | WO |
| WO 2023011503 | Feb 2023 | WO |
| WO 2023066020 | Apr 2023 | WO |
| WO 2023080310 | May 2023 | WO |
| WO 2023108881 | Jun 2023 | WO |
| WO 2023118023 | Jun 2023 | WO |
| WO 2023130108 | Jul 2023 | WO |
| WO 2023175610 | Sep 2023 | WO |
| WO 2023238038 | Dec 2023 | WO |
| WO 2023238039 | Dec 2023 | WO |
| WO 2023238040 | Dec 2023 | WO |
| WO 2023238041 | Dec 2023 | WO |
| Entry |
|---|
| US 10,398,895 B2, 09/2019, Tomás (withdrawn) |
| 2018 Cutera University, Clinical Forum, Cutera 20, 26 pages. |
| 501(k) K030708 Slendertone FLEX Letter from Department of Health and Humane Serivces, Public Health Service, Jun. 25, 2003, 6 pages. |
| 501(k) K163165 AM-100 Letter from Department of Health and Human Services, Public Health Service, Feb. 16, 2017, 9 pages. |
| Abulhasan, J.F., et al., “Peripheral Electrical and Magnetic Stimulation to Augment Resistance Training,” Journal of Functional Morphology and Kinesiology, 1(3):328-342, (Sep. 2016). |
| Accent Radiofrequency System, Operator's Manual, Alma Lasers, Wellbeing Through Technology, 2008, 82 Pages. |
| Agilent Technologies, Inc., “Agilent 33500 Series 30 MHz Function / Arbitrary Waveform Generator User's Guide,” Publication No. 33520-90001 (Dec. 2010), 278 pages. |
| Agilent Technologies, Inc., “Agilent Announces 30 MHz Function/Arbitrary Waveform Generators,” Microwave J., URL: (Aug. 3, 2010), 8 pages. |
| Allergan, Inc. et al v. BTL Healthcare Technologies A.S., PTAB-PGR2021-00015, Paper 16 (Decision Denying Institution of Post-Grant Review), Jun. 17, 2021, 20 pages. |
| Allergan, Inc et al v. BTL Healthcare Technologies A.S., PTAB-PGR2021-00016, Paper 16 (Decision Denying Institution of Post-Grant Review), Jun. 17, 2021, 20 pages. |
| Allergan, Inc et al v. BTL Healthcare Technologies A.S., PTAB-PGR2021-00017, Paper 16 (Decision Denying Institution of Post-Grant Review), Jun. 16, 2021, 33 pages. |
| Allergan, Inc et al v. BTL Healthcare Technologies A.S., PTAB-PGR2021-00018, Paper 16 (Decision Denying Institution of Post-Grant Review), Jun. 16, 2021, 42 pages. |
| Allergan, Inc et al v. BTL Healthcare Technologies A.S., PTAB-PGR2021-00020, Paper 16 (Decision Denying Institution of Post-Grant Review), Jun. 16, 2021, 35 pages. |
| Allergan, Inc et al v. BTL Healthcare Technologies A.S., PTAB-PGR2021-00021, Paper 17 (Decision Denying Institution of Post-Grant Review), Jun. 16, 2021, 33 pages. |
| Allergan, Inc. et al v. BTL Healthcare Technologies A.S., PTAB-PGR2021-00022; PTAB-PGR2021-00023; PTAB-PGR2021-00024; PTAB-PGR2021-00025; PTAB-IPR2021-00296; PTAB-IPR2021-00312, Paper 11 (Decision Settlement Prior to Institution of Trial), Jul. 6, 2021, 4 pages. |
| Alma Lasers., “Accent Radiofrequency System, Operator's Manual,” Wellbeing Through Technology, 2008, Chapters 1-8, Appendix A. |
| Arjunan, P.A., et al., “Computation and Evaluation of Features of Surface Electromyogram to Identify the Force of Muscle Contraction and Muscle Fatigue,” BioMed research international 2014:197960, Hindawi Pub. Co, United States (2014). |
| Avram, M.M and Harry, R.S.,“Cryolipolysis for Subcutaneous Fat Layer Reduction,” Lasers in Surgery and Medicine, 41(10):703-708, Wiley-Liss, United States (Dec. 2009). |
| Bachasson, D., et al., “Quadriceps Function Assessment Using an Incremental Test and Magnetic Neurostimulation: a Reliability Study,” Journal of Electromyography and Kinesiology, 23(3):649-658, Elsevier, England, (Jun. 2013). |
| Baranov, A., Krion, Whole Body Cryotherapy, Russia, 19 Pages. |
| Barker, A.T, “An Introduction to the Basic Principles of Magnetic Nerve Stimulation,” Journal of Clinical Neurophysiology, 8(1):26-37, Lippincott Williams & Wilkins, United States, (Jan. 1991). |
| Barker, A.T., et al., “Non-Invasive Magnetic Stimulation of Human Motor Cortex,” Lancet 1(8437):1106-1107, Elsevier, England (May 1985). |
| Barker, A.T., “The History and Basic Principles of Magnetic Nerve Stimulation,” Electroencephalography and Clinical Neurophysiology 51:3-21, Elsevier, Netherlands (1999). |
| Barrett, J., et al., “Mechanisms of Action Underlying the Effect of Repetitive Transcranial Magnetic Stimulation on Mood: Behavioral and Brain Imaging Studies,” Neuropsychopharmacology 29(6):1172-1189, Nature Publishing Group, England (Jan. 14, 2004). |
| Basic Protocol of Salus, Talent with Incontinence Chair, REMED, 1 page. |
| Behrens, M., et al., “Repetitive Peripheral Magnetic Stimulation (15 Hz RPMS) of the Human Soleus Muscle did not Affect Spinal Excitability,” Journal of Sports Science and Medicine, 10(1):39-44, Dept. of Sports Medicine, Medical Faculty of Uludag University, Turkey (Mar. 2011). |
| Beilin, G., et al., “Electromagnetic Fields Applied to the Reduction of Abdominal Obesity,” Journal of Cosmetic & Laser Therapy, 14(1):24-42, Informa Healthcare, England, (Feb. 2012). |
| Belanger, A-Y., “Chapter 13: Neuromuscular Electrical Stimulation,” in Therapeutic Electrophysical Agents: Evidence Behind Practice, 3rd Edition, Lupash, E., ed., pp. 220-255, Lippincott Williams & Wilkins, United States (2015). |
| Benton, et al., “Functional Electrical Stimulation—A Practical Clinical Guide,” Second Edition, The Professional Staff Association of the Rancho Los Amigos Hospital, Inc., 42 pages (1981). |
| Benton, L.A., et al., “Chapter 2: Physiological Basis of Nerve and Muscle Excitation” and “Chapter 4: General Uses of Electrical Stimulation,” in Functional Electrical Stimulation: A Practical Guide, 2nd Edition, pp. 11-30 and 53-71, Rancho Los Amigos Rehabilitation Engineering Center, Downey, CA (1981), 42 pages. |
| Bergh, U., and Ekblom, B., “Influence of Muscle Temperature on Maximal Muscle Strength and Power Output in Human Skeletal Muscles, ” Acta Physiologica Scandinavica 107(1):33-37, Blackwell Scientific Publications, England (Aug. 1979). |
| Binder-MacLeod, S.A., et al., “Force Output of Cat Motor Units Stimulated with Trains of Linearly Varying Frequency,” Journal of Neurophysiology 61(1):208-217, American Physiological Society, United States (Jan. 1989). |
| Binder-MacLeod, S.A., et al., “Use of a Catchlike Property of Human Skeletal Muscle to Reduce Fatigue,” Muscle & Nerve 14(9):850-857, John Wiley & Sons, United States (Sep. 1991). |
| Bio Medical Research Limited., “Slendertone Flex Abdominal Training System, Instructions for Use,” All pages (Aug. 2006). |
| Bio Medical Research Limited., “Slendertone Flex Max Instruction Manual,” All pages (Apr. 2006). |
| Bio-Medical Research Ltd., K010335, 510(k) Summary, Slendertone Flex, All pages (Sep. 2001). |
| Bio-Medical Research Ltd., K022855 510(k) Summary, Slendertone, 1-6 (Mar. 2003). |
| Bischoff, C., et al., “Repetitive Magnetic Nerve Stimulation: Technical Considerations and Clinical Use in the Assessment of Neuromuscular Transmission,” Electroencephalography and Clinical Neurophysiology 93(1):15-20, Elsevier, Ireland (Feb. 1994). |
| Bourland, J.D., et al., “Transchest Magnetic (Eddy-Current) Stimulation of the Dog Heart,” Medical & Biological Engineering & Computing 28(2):196-198, Springer, United States (Mar. 1990). |
| BTL Industries, Inc., K163165 510(k) Summary, AM-100, All pages (Feb. 2017). |
| BTL Industries, Inc., K180813 510(k) Summary, Emsculpt, All pages (Mar. 2018). |
| BTL Industries, Inc. v. Allergan Ltd. et al DDE-1-20-cv-01046, Complaint for Patent Infringement and Exhibits 1-38, 821 pages (Aug. 2020). |
| BTL Industries, Inc. v. Allergan Ltd. et al., DDE-1-20-cv-01046, Order Administratively Closing Case, Jul. 26, 2021, 1 page. |
| BTL Industries, Inc. v. Allergan Ltd. et al DDE-1-20-cv-01046, Order Granting Motion to Stay Pending Resolution of Proceedings at the International Trade Commission (Unopposed), 2 pages (Oct. 2020). |
| BTL Industries, Inc. v. Allergan PLC et al DDE-1-19-cv-02356, Complaint for Patent Infringement and Exhibits 1-34, 375 pages (Dec. 2019). |
| BTL Industries, Inc. v. Allergan PLC et al DDE-1-19-cv-02356, Order Granting Stipulation to Stay, Oct. 1, 2020, 1 page. |
| BTL Industries, Inc. v. Allergan USA, Inc et al., DDE-1-19-cv-02356, Order Administratively Closing Case, Jul. 26, 2021, 1 page. |
| Buenos Aires, Oct. 14, 2014, Venus Concept, Provision No. 7246, 56 pages (With Machine Translation). |
| Burge, S.M and Dawber, R.P., “Hair Follicle Destruction and Regeneration in Guinea Pig Skin After Cutaneous Freeze Injury,” Cryobiology, 27(2):153-163, Elsevier, Netherlands (Apr. 1990). |
| Busso, M. and Denkova, R., “Efficacy of High Intensity Focused Electro-Magnetic (HIFEM) Field Therapy When Used For Non-Invasive Buttocks Augmentation and Lifting: A Clinical Study” American Society for Laser Medicine and Surgery Abstracts, 382 (2018). |
| Bustamante, V., et al., “Muscle Training With Repetitive Magnetic Stimulation of the Quadriceps in Severe COPD Patients,” Respiratory Medicine, 104(2):237-245, Elsevier, England, (Feb. 2010). |
| Bustamante, V., et al., “Redox Balance Following Magnetic Stimulation Training in the Quadriceps of Patients With Severe COPD,” Free Radical Research, 42(11-12):939-948, Informa Healthcare, England, (Nov. 2008). |
| Callaghan, M.J., et al., “Electric Muscle Stimulation of the Quadriceps in the Treatment of Patellofemoral Pain,” Archives of Physical Medicine and Rehabilitation 85(6):956-962, W.B. Saunders, United Staes (Jun. 2004). |
| Carbonaro, M., et al., “Architectural Changes in Superficial and Deep Compartments of the Tibialis Anterior during Electrical Stimulation over Different Sites,” IEEE transactions on Neural Systems and Rehabilitation Engineering 28(11):2557-2565, IEEE, United States (Nov. 2020). |
| Caress, J.B., et al., “A Novel Method of Inducing Muscle Cramps Using Repetitive Magnetic Stimulation,” Muscle Nerve, 23(1):126-128, John Wiley & Sons, United States, (Jan. 2000). |
| Certain Non-Invasive Aesthetic Body Contouring Devices, Components Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, BTL's Statement of Suggested Claim Terms to Be Construed Pursuant to Ground Rule 6b, Nov. 4, 2020, 2 pages. |
| Certain Non-Invasive Aesthetic Body Contouring Devices, Components Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, Complainant BTL's Proposed Construction of Disputed Claim Terms, Dec. 8, 2020, 19 pages. |
| Certain Non-Invasive Aesthetic Body Contouring Devices, Components Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, Complaint, Aug. 5, 2020, 93 pages. |
| Certain Non-Invasive Aesthetic Body Contouring Devices, Components Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, Joint Claim Construction Chart, Dec. 14, 2020, 15 pages. |
| Certain Non-Invasive Aesthetic Body Contouring Devices, Components Thereof, and Methods of Using the Same; Inv. No. 337-TA-1219, Joint Claim Construction Chart, Dec. 18, 2020, 15 pages. |
| Certain Non-Invasive Aesthetic Body Contouring Devices, Components Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, Respondents' Allergan Limited, Allergan USA, Inc., Allergan, Inc., Zeltiq Aesthetics, Inc., Zeltiq Ireland Unlimited Company, and Zimmer MedizinSysteme GmbH's Notice of Prior Art, Nov. 20, 2020, 5 pages. |
| Certain Non-Invasive Aesthetic Body Contouring Devices, Components Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, Respondents' List of Claim Terms for Construction, Nov. 4, 2020, 8 pages. |
| Certain Non-Invasive Aesthetic Body Contouring Devices, Components Thereof, and Methods of Using the Same; Inv. No. 337-TA-1219, Respondents' List of Proposed Claim Constructions and Their Intrinsic and Extrinsic Support, filed Dec. 15, 2020, 23 pages. |
| Certain Non-Invasive Aesthetic Body Contouring Devices, Components Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, Response of Respondent Zimmer MedizinSysteme GmbH to the Complaint and Notice of Investigation, Oct. 22, 2020, 68 pages. |
| Certain Non-Invasive Aesthetic Body Contouring Devices, Components Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, Response of Respondents Allergan Limited, Allergan USA, Inc., Allergan, Inc., Zeltiq Aesthetics, Inc., and Zeltiq IrelandUnlimited Company to the Complaint and Notice of Investigation, Oct. 22, 2020, 69 pages. |
| Certain Non-Invasive Aesthetic Body-Contouring Devices, Components Thereof, and Methods of Using Same, Notice of Institution of Investigation, Inv. No. 337-TA-1219, Notice of Institution of Investigation, Sep. 2, 2020, 21 pages. |
| Certain Non-Invasive Aesthetic Body-Contouring Devices, Components Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, Order No. 21 (Initial Determination), Apr. 28, 2021, 5 pages. |
| Certain Non-Invasive Aesthetic Body-Contouring Devices, Components Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, Order No. 30 (Order Concerning the Procedural Schedule), Aug. 4, 2021, 3 pages. |
| Certain Non-Invasive Aesthetic Body-Contouring Devices, Componesnts Thereof, and Methods of Using the Same, Inv. No. 337-TA-1219, Order No. 17: Amending Procedural Schedule, Apr. 9, 2021, 4 pages. |
| Certified English Translation of Belyaev, A.G., “Effect of Magnetic Stimulation on the Strength Capacity of Skeletal Muscles,” Ph.D. Thesis Abstract, Smolensk State Academy of Physical Culture, Sport, and Tourism, Dec. 11, 2020, 23 pages. |
| Certified English Translation of Belyaev, A.G., “Effect of Magnetic Stimulation on the Strength Capacity of Skeletal Muscles,” Ph.D. Thesis, Smolensk State Academy of Physical Culture, Sport, and Tourism, Dec. 11, 2020, 117 pages. |
| Chattanooga Group of Encore Medical, L.P., “Intelect SWD 100 User Manual, Operation & Installation Instructions for Intelect SWD 00—Model 1600,” All pages (2009). |
| Chesterton, L.S., et al., “Skin Temperature Response to Cryotherapy,” Archives of Physical Medicine and Rehabilitation, 83(4):543-549, W.B. Saunders, United States (Apr. 2002). |
| Clinical Application of Electro Magnetic Stimulation, Salus-Talent, Korea Society of interventional Muscle and Soft Tissue Stimulation Therapy, CR Technology, 141 pages. |
| Collins, D.F., et al., “Large Involuntary Forces Consistent With Plateau-Like Behavior of Human Motoneurons,” Journal of Neuroscience 21(11):4059-4065, Society for Neuroscience, United States (Jun. 2001). |
| Colson, S., et al., “Re-Examination of Training Effects by Electrostimulation in the Human Elbow Musculoskeletal System,” International Journal of Sports Medicine 21(4):281-288, Stuttgart, Thieme (May 2000). |
| Course in Physical Therapy, Presentation, Jan. 4, 2013, 156 pages. |
| CR Technologies, “Salus Talent Pop Manual KFDA First Approval Document” (English Translation), Nov. 25, 2011, 47 pages. |
| CR Technologies, “Notification of medical device manufacturing item permission, Salus Talent Pop KFDA Approval Document” (English Translation), 3 pages (Sep. 2011). |
| CR Technology Co, Ltd., “Salus-Talent Double Sales Brochure” 2 pages, (Oct. 2020). |
| CR Technology Co. Ltd., “Medical Laser Irradiator Salus-Talent-Pop User Manual Version 1.00” (Nov. 2020). |
| CR Technology Co. Ltd., Salus Talent Pop User Manual, Ver. 1.00, All pages, Approx. 2012. |
| CR Technology, Salus-Talent, Technical File of Electro-magnetic Stimulator, Document No. TF-C05, 2008, 241 pages. |
| CR Technology, Technology for Health and Business for Human Being, investor relations, 2008, 21 pages. |
| CryoGenTech GmbH, Company Profile, Creating CRYO, Medica, 9 pages. |
| Currier, D. P., “Effects of Electrical and Electromagnetic Stimulation after Anterior Cruciate Ligament Reconstruction,” The Journal of Orthopaedic and Sports Physical Therapy 17(4):177-84, Williams And Wilkins, United States (1993). |
| Cutera, truSculptflex, Brochure, dated 2019, 2 pages. |
| CynoSure, SculpSure TM, The New Shape of Energy-Based bodyContouring, 2015, Cynosure INC, 2 pages. |
| Cynosure,Smooth Shapes XV, Now with Smoothshape petite, Transforming non-invasive Body Shaping,Retrieved from the Internet: (www.cynosure.com), 2011, Cynosure Inc, 8 pages. |
| Davies, C.T., et al., “Contractile Properties of the Human Triceps Surae With Some Observations on the Effects of Temperature and Exercise,” European Journal of Applied Physiology and Occupational Physiology 49(2):255-269, Springer Verlag, Germany (Aug. 1982). |
| Deng, Z.D., et al., “Electric Field Depth-Focality Tradeoff in Transcranial Magnetic Stimulation: Simulation Comparison of 50 Coil Designs,” Brain stimulation 6(1):1-13, Elsevier, New York (Jan. 2013). |
| Depatment of Health and Human Services, 501(k) Letter and Summary for K092476 Body Control System 4M Powered Muscle Stimulator, dated May 7, 2010, 5 pages. |
| Depatment of Health and Human Services, 501(k) Letter and Summary for K160992 HPM-6000 Powered Muscle Stimulator, dated Oct. 21, 2016, 9 pages. |
| Depatment of Health and Human Services, 501(k) Letter and Summary for K163415 SlimShape System Powered Muscle Stimulator, dated Apr. 20, 2017, 8 pages. |
| Depatment of Health and Human Services, 501(k) Letter and Summary for K182106 BTL 799-2T Powered Muscle Stimulator, dated Oct. 23, 2018, 9 pages. |
| Depatment of Health and Human Services, 501(k) Letter and Summary for K190456 BTL 799-2L Powered Muscle Stimulator, dated Jul. 5, 2019, 9 pages. |
| Depatment of Health and Human Services, 501(k) Letter and Summary for K192224 BTL 899 Powered Muscle Stimulator, dated Dec. 5, 2019, 11 pages. |
| Doucet, B., et al., “Neuromuscular Electrical Stimulation for Skeletal Muscle Function,” Yale Journal of Biology & Medicine 85:201-215, Yale Journal of Biology and Medicine, United States (Jun. 2012). |
| Dudley, G. and Stevenson, S., “Use of Electrical Stimulation in Strength and Power Training,” Special Problems in Strength and Power Training: 426-435 (2003). |
| Duncan, D., et al., “Noninvasive Induction of Muscle Fiber Hypertrophy and Hyperplasia: Effects of High-Intensity Focused Electromagnetic Field Evaluated in an In-Vivo Porcine Model: A Pilot Study,” Aesthetic Surgery Journal 40(5):568-574, Oxford University Press, United States (Apr. 2020). |
| DuoMAG Magnetic Stimulator, Alien Technik User Manuel, Jun. 26, 2012,48 pages, Version 2.1. |
| Dybek, T., et al., “Impact of 10 Sessions of Whole Body Cryostimulation on Aerobic and Anaerobic Capacity and on Selected Blood Count Parameters,” Biology of Sport, 29(1):39-43 (Jan. 2012). |
| Dynatronics, “Better Rehab Solutions for Better Outcomes,” Rehabilitation Products Guide 2.3, 2017, 52 pages. |
| Effective PEMF Magnetic Fat Reduction Slimming Body Beauty Salon Machine (PEMF Star), Wolfbeauty 1980, PEMF Star, China, Retrieved from the Internet: (URL: https://www.ec21.com/product-details/Effective-PEMF-Magnetic-Fat-Reduction--8928746.html), 2019, 5 pages. |
| Elamed, Magnetic Therapeutic Apparatus for Running Pulse Mag-field small-sized ALMAG-01 Manual, allegedly accessed on Nov. 18, 2020, All pages. |
| Eliminate Stubborn Fat without Surgery or Downtime and Feel Great From Every Angle, Fear No Mirror®, Consultation Guide, Coolsculpting, 2014, 20 pages. |
| EndyMed PRO, 3 Deep, 3 Dimensional Control of the Target Zone, A Brilliant RadioFrequency Innovation, Eclipse Aesthetics, 7 Pages. |
| Energist Ltd—Acquired Chromogenez—Old Account, iLipo—Laser Liposuction (i-Lipo), Video Screenshots, Aug. 10, 2009, 5 pages. |
| Enoka, R.M., “Muscle Strength and Its Development,” Sports Medicine 6:146-168, Springer (Oct. 1988). |
| Epstein, C., et al., “The Oxford Handbook of Transcranial Stimulation,” 773 pages (2008). |
| European Commission, “Neurogenerative Disorders,” 10 pages printed Dec. 27, 2016. |
| European Patent Office, International Search Report and Written Opinion for International Application No. PCT/IB2016/053930, dated Dec. 12, 2016, 19 pages. |
| Exilis, Operator's Manual, BTL, 2012, 44 Pages. |
| Faghri, P.D., et al., “The Effects of Functional Electrical Stimulation on Shoulder Subluxation, Arm Function Recovery, and Shoulder Pain in Hemiplegic Stroke Patients,” Archives of Physical Medicine and Rehabilitation 75(1):73-79, W.B. Saunders, United States (Jan. 1994). |
| Fischer, J., et al., “Precise Subpixel Position Measurement with Linear Interpolation of CMOS Sensor Image Data,” The 6th IEEE International Conference on Intelligent Data Acquisition and Advanced Computing Systems, 500-504 (Sep. 2011). |
| Fisher, R., et al., “ILAE Official Report: a Practical Clinical Definition of Epilepsy,” Epilepsia, 55(4):475-482, Blackwell Science, United States (Apr. 2014). |
| FMS Tesla STYM—AKCE, Medila Cenova nabidika, Price offerc. 191, 24 pages. |
| Fujimura, K., et al., “Effects of Repetitive Peripheral Magnetic Stimulation on Shoulder Subluxations Caused by Stroke: A Preliminary Study,” Neuromodulation: Journal of the International Neuromodulation Society 23(6):847-851, Wiley-Blackwell, United States (Nov. 2020). |
| Gaines, M., “Slendertone Abdominal Training System, the First FDA-Cleared Abdominal Belt, Introduced in United States by Compex Technologies on Time for Holiday Gift-Giving,” Business Wire 44199 (Oct. 2003). |
| Geddes, L.A., “History of Magnetic Stimulation of the Nervous System,” Journal of Clinical Neurophysiology 8(1):3-9, Lippincott Williams & Wilkins, United States (Jan. 1991). |
| Goetz, S.M., et al., “Coil Design for Neuromuscular Magnetic Stimulation Based on a Detailed 3-D Thigh Model,” IEEE Transactions On Magnetics, 50(6):10, IEEE, (Jun. 2014). |
| Goodman, B.E., “Channels Active in the Excitability of Nerves and Skeletal Muscles Across the Neuromuscular Junction: Basic Function and Pathophysiology,” Advances in Physiology Education 32(2):127-135, American Physiological Society, United States (Jun. 2008). |
| Gorgey, A., et al., “Effects of Electrical Stimulation Parameters on Fatigue in Skeletal Muscle,” The Journal of Orthopaedic and Sports Physical Therapy 39(9):684-692, Williams And Wilkins, United States (Sep. 2009). |
| Gorodnichev, R.M., et al., “The Effect of Electromagnetic Stimulation on the Parameters of Muscular Strength,” Human Physiology 40:65-69 (2014). |
| Gorodnichev, R.M., “Magnetic Stimulation of Muscles as New Method to Enhance Their Strength, ” Velikie Luki State Academy of Physical Culture and Sport, Velikie Luki, 2016, 5 pages. |
| Halaas, Y. and Bernardy, J., “Biochemical Perspective of Fat Physiology after Application of HIFEM Field Technology: Additional Investigation of Fat Disruption Effects in a Porcine Study,” American Society for Laser Medicine and Surgery Abstracts, S4 (2019). |
| Hamnegard, C.H., et al., “Quadriceps Strength Assessed by Magnetic Stimulation of the Femoral Nerve in Normal Subjects, ” Clinical Physiology and Functional Imaging, 24(5):276-280, Blackwell, England, (Sep. 2004). |
| Han, B.H., et al., “Development of four-channel magnetic nerve stimulator,” 2001 Proceedings of the 23rd Annual EMBS International Conference, pp. 1325-1327, Turkey (2001). |
| Han, T.R., et al., “Magnetic Stimulation of the Quadriceps Femoris Muscle: Comparison of Pain With Electrical Stimulation,” American Journal of Physical Medicine & Rehabilitation, 85(7):593-599, Lippincott Williams & Wilkins, United States, (Jul. 2006). |
| Harkey, M.S., “Disinhibitory Interventions and Voluntary Quadriceps Activation: A Systematic Review,” Journal of Athletic Training 49(3):411-421, National Athletic Trainers' Association, United States (2014). |
| Hasala, O., et al., Case Study of Treating Acute Ankle Distortion Using TMS, Charles University, Faculty of Physical Education and Sports, Prague, Czech Republic, 4 Pages. |
| Heidland, A., et al., “Neuromuscular Electrostimulation Techniques: Historical Aspects and Current Possibilities in Treatment of Pain and Muscle Waisting,” Clinical Nephrology 79 Suppl 1:S12-S23, Dustri-Verlag Dr. Karl Feistle, Germany (Jan. 2012). |
| Heisel, Jurgen, Physikalische Medizin, Stuttgart: Georg Thieme Verlag KG, 2005. ISBN 3-13-139881-7. p. 159. |
| Hera Estetik Medikal, “LIPOSTAR” dated Jul. 7, 2014, accessed at https://www.youtube.com/watch?v=-R7OnFIK9go, accessed on Dec. 15, 2021. |
| Hera Estetik Medikal, “Lipostar Manyetik Incelme”, accessed at https://www.heraestetik.com/en/urundetay/liposter-manyetik-incelme, accessed on Dec. 15, 2021. |
| Hill, A., “The Influence of Temperature on the Tension Developed in an Isometric Twitch,” Proceeding of the Royal Society B 138:349-354, (Sep. 1951). |
| Hirvonen, H.E., et al., “Effectiveness of Different Cryotherapies on Pain and Disease Activity in Active Rheumatoid Arthritis. A Randomised Single Blinded Controlled Trial,” Clinical and Experimental Rheumatology, 24(3):295-301, Clinical and Experimental Rheumatology S.A.S, Italy (May-Jun. 2006). |
| Hovey, C. and Jalinous, R., “The Guide to Magnetic Stimulation” Magstim, Pioneers in Nerve Stimulation and Monitoring, pp. 1-44 (2016). |
| Hovey, C., et al., “The Guide to Magnetic Stimulation,” The Magstim Company Limited, 48 pages (Jul. 2006). |
| Huang, Y.Z., et al., “Theta Burst Stimulation of the Human Motor Cortex,” Neuron 45(2):201-206, Cell Press, United States (Jan. 2005). |
| I-Lipo by Chromo genex, i-Lipo Ultra is the Intelligent, Non-Surgical Alternative to Liposuction, 2011, 2 pages. |
| Increasing Physiotherapy Presence in Cosmetology, Spa Inspirations, Jan. 2012, pp. 34-35. |
| Irazoqui P., Post Grant Review of U.S. Pat. No. 10,695,576, PTAB-PGR2021-00024, filed as EX1085, Dec. 14, 2020, 25 pages. |
| Iskra Medical, Magneto System, 2012, 2 pages. |
| Iskra Medical, “TESLA Stym—Functional Magnetic Stimulation FMS,” Nov. 2013, http://ww.iskramedical.eu/magneto-therapy-medical/tesla-stym, 5 pages. |
| Iskra Medical, “TESLA Stym Website,” URL: https://web.archive.org/web/20131106123126/http:/www.iskramedical.eu:80/magneto-therapy-medical/tesla-stym (Nov. 6, 2013). |
| Izumiya, Y., et al., “Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice”, Cell Metabolism 7(2):159-172, Cell Press, United States (Feb. 2008). |
| Jacob, C., et al., “High Intensity Focused Electro-Magnetic Technology (HIFEM) for Non-Invasive Buttock Lifting and Toning of Gluteal Muscles: A Multi-Center Efficacy And Safety Study,” Journal of Drugs in Dermatology 17(11):1229-1232, Physicians Continuing Education Corporation, United States (Nov. 2018). |
| Jacob, C.I., et al., “Safety And Efficacy of a Novel High-Intensity Focused Electromagnetic Technology Device for Noninvasive Abdominal Body Shaping,” Journal of Cosmetic Dermatology, 17(5):783-787, Blackwell Science, United States (Oct. 2018). |
| Jacobm C., and Paskova, “A Novel Non-Invasive Technology Based on Simultaneous Induction of Changes in Adipose and Muscle Tissues: Safety and Efficacy of a High Intensity Focused Electro-Magnetic (HIFEM) Field Device Used For Abdominal Body Shaping,” American Society for Laser Medicine and Surgery, 2018 Electronic Posters (ePosters) Town Hall and ePosters, 369, p. 1, Wiley Periodicals, Inc. (2018). |
| Jalinous, R., “Technical and Practical Aspects of Magnetic Nerve Stimulation,” Journal of Clinical Neurophysiology 8(1):10-25, Lippincott Williams & Wilkins, United States (Jan. 1991). |
| Jeanrenaud, B., “Lipid components of adipose tissue,” Handbook of Physiology, Adipose Tissue, Chapter 15, 8 Pages. |
| Johari Digital Healthcare Ltd., 510(k)—K062439 Powertone Letter from Department of Health and Humane Services Summary, Public Health Service, Jan. 8, 2007, 6 pages. |
| Johari Digital Healthcare Ltd., “510(k)—K131291 Torc Body Letter from Department of Health and Humane Services”, Public Health Service, Jun. 14, 2013, 10 pages. |
| Johari Digital Healthcare Ltd., K131291 510(k) Summary, TorcBody, All pages (Jun. 2013). |
| Jutte, L.S., et al., “The Relationship Between Intramuscular Temperature, Skin Temperature, and Adipose Thickness During Cryotherapy and Rewarming,” Archives of Physical Medicine and Rehabilitation, 82(6):845-850, W.B. Saunders, United States (Jun. 2001). |
| Katuscakova, Z.L., et al., High Induction Magnet Therapy in Rehabilitation, Department of Physiactric Rehabilitation, 2012, 72 pages. |
| Katz, B., et al., “Changes in Subcutaneous Abdominal Fat Thickness Following High-Intensity Focused Electro-Magnetic (HIFEM) Field Treatments: A Multi Center Ultrasound Study,” American Society for Laser Medicine and Surgery Abstracts, 360-361 (2018). |
| Katz, B., et al., “Ultrasound Assessment of Subcutaneous Abdominal Fat Thickness after Treatments with a High-Intensity Focused Electromagnetic Field Device: A Multicenter Study,” Dermatologic Surgery 45(12):1542-1548, Williams & Wilkins, United States (Dec. 2019). |
| Kavanagh, S., et al., “Use of a Neuromuscular Electrical Stimulation Device for Facial Muscle Toning: A Randomized, Controlled Trial,” Journal of Cosmetic Dermatology 11(4):261-266, Blackwell Science, United States (Dec. 2012). |
| Kent, D., and Jacob C., “Computed Tomography (CT) Based Evidence of Simultaneous Changes in Human Adipose and Muscle Tissues Following a High Intensity Focused Electro-Magnetic Field (HIFEM) Application: A New Method for Non-Invasive Body Sculpting,” American Society for Laser Medicine and Surgery Abstracts, p. 370 (2018). |
| Kent, D,E. and Jacob, C.I., Simultaneous Changes in Abdominal Adipose and Muscle Tissues Following Treatments by High-Intensity Focused Electromagnetic HIFEM Technology-Based Device: Computed Tomography Evaluation, Journal of Drugs in Dermatology 18(11):1098-1102, Physicians Continuing Education Corporation, United States (Nov. 2019). |
| Kim, Y.H., et al., “The Effect of Cold Air Application on Intra-Articular and Skin Temperatures in the Knee,” Yonsei Medical Journal, 43(5):621-626, Yonsei University, Korea (South) (Oct. 2002). |
| Kinney, B.M. and Lozanova P., “High Intensity Focused Electromagnetic Therapy Evaluated by Magnetic Resonance Imaging: Safety and Efficacy Study of a Dual Tissue Effect Based Non-Invasive Abdominal Body Shaping,” Lasers in Surgery and Medicine 51(1):40-46, Wiley-Liss, United States (Jan. 2019). |
| Kocbach et al., “A Simulation Approach to Optimizing Perfermance of Equipment for Thermostimulation of Muscle Tissue using COMSOL Multiphysics” Article in Biophysics & Bioeng, dated 2011, 26 pages. |
| Kolin, A., et al., “Stimulation of Irritable Tissues by means of an Alternating Magnetic Field,” Proceedings of the Society for Experimental Biology and Medicine 102:251-253, Blackwell Science, United States (Oct. 1959). |
| Korman, P., et al., “Temperature Changes In Rheumatoid Hand Treated With Nitrogen Vapors and Cold Air,” Rheumatology International, 32(10):2987-2992, Springer International, Germany (Oct. 2012). |
| Kotz, Y., “Theory and Practice of Physical Culture,” Training of Skeletal Muscle With Method of Electrostimulation, 64-67 (Mar. 1971). |
| Kotz, Y., “Theory and Practice of Physical Culture,” Training of Skeletal Muscle With Method of Electrostimulation, 66-72 (Apr. 1971). |
| Krueger, N. et al., “Safety and Efficacy of a New Device Combining Radiofrequency and Low-Frequency Pulsed Electromagnetic Fields for the Treatment of Facial Rhytides,” Journal of Drugs in Dermatology 11(11):1306-1309, Physicians Continuing Education Corporation, United States (Nov. 2012). |
| Kumar, N. and Agnihotri, R.C., “Effect of Frequency and Amplitude of Fes Pulses on Muscle Fatigue During Toning of Muscles,” Journal of Scientific and Industrial Research 67(4):288-290, (Apr. 2008). |
| Lampropoulou, S.I., et al., “Magnetic Versus Electrical Stimulation in the Interpolation Twitch Technique of Elbow Flexors,” Journal of Sports Science and Medicine, 11(4):709-718, Dept. of Sports Medicine, Medical Faculty of Uludag University, Turkey (Dec. 2012). |
| Langford, J. and McCarthy, P.W., “Randomised controlled clinical trial of magnet use in chronic low back pain; a pilot study,” Clinical Chiropractic 8(1):13-19, Elsevier (Mar. 2005). |
| Lee, P.B., et al., “Efficacy of Pulsed Electromagnetic Therapy for Chronic Lower Back Pain: a Randomized, Double-blind, Placeb-controlled Study,” The Journal of International Medical Research 34(2):160-167, Cambridge Medical Publications, England (Mar.-Apr. 2006). |
| Leitch, M., et al., “Intramuscular Stimulation of Tibialis Anterior in Human Subjects: The Effects of Discharge Variability on Force Production and Fatigue,” Physiological Reports 5(15):e13326, Wiley Periodicals, Inc., United States (Aug. 2017). |
| Leon-Salas, W.D., et al., “A Dual Mode Pulsed Electro-Magnetic Cell Stimulator Produces Acceleration of Myogenic Differentiation,” Recent Patents on Biotechnology 7(1):71-81, Bentham Science Publishers, United Arab Emirates (Apr. 2013). |
| Letter from Department of Health and Human Services, Public Health Service, Dec. 19, 2014, 7 pages. |
| Lin, V.W., et al., “Functional Magnetic Stimulation: A New Modality for Enhancing Systemic Fibrinolysis,” Archives of Physical Medicine and Rehabilitation 80(5):545-550, W.B. Saunders, United States (May 1999). |
| Lin, V.W., et al., “Functional Magnetic Stimulation for Conditioning of Expiratory Muscles in Patients with Spinal Cord Injury.,” Archives of Physical medicine and Rehabilitation 82(2):162-166, W.B. Saunders, United States (Feb. 2001). |
| Lin, V.W., et al., “Functional Magnetic Stimulation for Restoring Cough in Patients With Tetraplegia,” Archives of Physical Medicine and Rehabilitation, 79(5):517-522, W.B. Saunders, United States, (May 1998). |
| Lin, V.W., et al., “Functional Magnetic Stimulation of Expiratory Muscles: a Noninvasive and New Method for Restoring Cough,” Journal of Applied Physiology (1985), 84(4):1144-1150, American Physiological Society, United States, (Apr. 1998). |
| Lin, V.W., et al., “Functional Magnetic Stimulation of the Respiratory Muscles in Dogs,” Muscle & Nerve 21(8):1048-1057, John Wiley & Sons, United States (Aug. 1998). |
| Linehan, C., et al., Brainwave the Irish EpilepsyAssoication, “The Prevalence of Epilepsy in Ireland” Summary Report,pp. 1-8 (May 2009). |
| Lotz, B.P., et al., “Preferential Activation of Muscle Fibers with Peripheral Magnetic Stimulation of the Limb,” Muscle & Nerve, 12(8):636-639, John Wiley & Sons, United States (Aug. 1989). |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01402, Declaration of Dr. Marom Bikson (EX1002), Sep. 13, 2021, 244 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01402, U.S. Pat. No. 10,821,295 Petition for Inter Partes Review, Sep. 13, 2021, 81 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01403, Declaration of Dr. Marom Bikson (EX1002), Sep. 13, 2021, 243 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01403, U.S. Pat. No. 10,821,295 Petition for Inter Partes Review, Sep. 13, 2021, 84 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01404, Declaration of Dr. Marom Bikson (EX1002), Sep. 13, 2021, 245 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01404, U.S. Pat. No. 10,124,187 Petition for Inter Partes Review, Sep. 13, 2021, 82 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01405, Declaration of Dr. Marom Bikson (EX1002), Sep. 13, 2021, 247 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01405, U.S. Pat. No. 10,124,187 Petition for Inter Partes Review, Sep. 13, 2021, 86 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2022-00126, Declaration of Dr. Marom Bikson (EX1002), Nov. 10, 2021, 263 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2022-00126, U.S. Pat. No. 10,695,576 Petition for Inter Partes Review, Nov. 10, 2021, 83 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2022-00127, Declaration of Dr. Marom Bikson (EX1002), Nov. 10, 2021, 269 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2022-00127, U.S. Pat. No. 10,695,576 Petition for Inter Partes Review, Nov. 10, 2021, 84 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2022-00451, Declaration of Dr. Marom Bikson (EX1002), Jan. 24, 2022, 236 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2022-00451, U.S. Pat. No. 10,806,943 Petition for Inter Partes Review, Jan. 24, 2022, 87 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2022-00452, Declaration of Dr. Marom Bikson (EX1002), Jan. 24, 2022, 229 pages. |
| Lumenis Be Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2022-00452, U.S. Pat. No. 10,806,943 Petition for Inter Partes Review, Jan. 24, 2022, 81 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01273, Declaration of Dr. Marom Bikson (EX1002), Aug. 13, 2021, 225 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01273, U.S. Pat. No. 10,478,634, Petition for Inter Partes Review, Aug. 13, 2021, 70 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01275, Declaration of Dr. Marom Bikson (EX1002), Aug. 5, 2021, 282 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01275, U.S. Pat. No. 10,632,321, Petition for Inter Partes Review, Aug. 5, 2021, 92 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01276, Declaration of Dr. Marom Bikson (EX1002), Aug. 5, 2021, 241 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01276, U.S. Pat. No. 10,965,575, Petition for Inter Partes Review, Aug. 5, 2021, 79 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01278, Declaration of Dr. Marom Bikson (EX1002), Aug. 13, 2021, 255 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01278, U.S. Pat. No. 10,709,894, Petition for Inter Partes Review, Aug. 13, 2021, 85 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01279, Declaration of Dr. Marom Bikson (EX1002), Aug. 5, 2021, 258 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01279, U.S. Pat. No. 10,709,895, Petition for Inter Partes Review, Aug. 5, 2021, 88 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01280, Declaration of Dr. Marom Bikson (EX1002), Aug. 13, 2021, 235 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01280, U.S. Pat. No. 10,478,634, Petition for Inter Partes Review, Aug. 13, 2021, 69 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01282, Declaration of Dr. Marom Bikson (EX1002), Aug. 5, 2021, 267 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01282, U.S. Pat. No. 10,632,321, Petition for Inter Partes Review, Aug. 5, 2021, 89 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01283, Declaration of Dr. Marom Bikson (EX1002), Aug. 5, 2021, 241 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01283, U.S. Pat. No. 10,695,575, Petition for Inter Partes Review, Aug. 5, 2021, 84 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01284, Declaration of Dr. Marom Bikson (EX1002), Aug. 5, 2021, 279 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01284, U.S. Pat. No. 10,709,895, Petition for Inter Partes Review, Aug. 5, 2021, 93 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01285, Declaration of Dr. Marom Bikson (EX1002), Aug. 13, 2021, 249 pages. |
| Lumenis Ltd. v. BTL Healthcare Technologies A.S., PTAB-IPR2021-01285, U.S. Pat. No. 10,709,894, Petition for Inter Partes Review, Aug. 13, 2021, 79 pages. |
| Madariaga, V.B., et al., “[Magnetic Stimulation of the Quadriceps: Analysis of 2 Stimulators Used for Diagnostic and Therapeutic Applications],” Archivos De Bronconeumología, 43(7):411-417, Elsevier Espana, Spain, (Jul. 2007). |
| Maffiuletti, N.A., et al., “Activation of Human Plantar Flexor Muscles Increases After Electromyostimulation Training,” Journal of Applied Physiology 92(4):1383-1392, American Physiological Society, United States (Nov. 2001). |
| Maffiuletti, N.A., et al., “The Effects of Electromyostimulation Training and Basketball Practice on Muscle Strength and Jumping Ability,” International journal of sports medicine 21(6):437-443, Thieme, Germany (Aug. 2000). |
| MAG and MORE Gmbh, Magnetic and Life Science System, Power Mag, 12 Pages. |
| MAG Expert, 2 pages. |
| Mag Venture, Magnetic Stimulation, Accessories Catalogue, Accessories Catalogue, 2011, 54 pages. |
| Magstim Company Limited, K051864 510(k) Summary, Magstim Rapid and Magstim Super Rapid, All pages (Dec. 2005). |
| Magstim Company US, LLC, K060847 510(k) Summary, Magstim Model 200-2 with Double 70mm Remote Coil, All pages (Sep. 2006). |
| Magstim Corporation US, K992911 510(k) Summary, Magstim Rapid, All pages (Jan. 2000). |
| Magventure, MagPro® by MagVenture®, Versatility in Magnetic Stimulation, World Leading Transcranial Magnetic Stimulation Systems, 2011, 6 Pages. |
| Man, W.D-C., et al., “Magnetic Stimulation for the Measurement of Respiratory and Skeletal Muscle Function,” The European Respiratory Journal 24(5):846-60, European Respiratory Society, England (2004). |
| Manstein, D., et al., “Selective Cryolysis: A Novel Method of Non-Invasive Fat Removal,” Lasers in Surgery and Medicine, 40(9):595-604, Wiley-Liss, United States (Nov. 2008). |
| Mantis, The non-invasive solution that restores natural beauty, improves health, and offers a renewed psychophysical sense of balance, MR991 theramagnetic, 2020, 8 pages. |
| MANTIS Theramagnetic Compact: the compact that guarantees utmost efficiency and maximum performance, theramagnetic, 2020, 8 pages. |
| Mantovani, A., et al., “Applications of Transcranial Magnetic Stimulation to Therapy in Pyschiatry,” Psychiatric Times 21(9), Intellisphere, 29 pages (Aug. 2004). |
| Marek Heinfarth, “Lipostar” dated Jan. 9, 2013, accessed at https://www.youtube.com/watch?v=hZurkn8iU_U, accessed on Dec. 15, 2021. |
| Markov, M.S., “Pulsed Electromagnetic Field Therapy History, State of the Art and Future,” Environment Systems and Decisions 27(4):465-475, Springer (Dec. 2007). |
| MecoTec Freezing Technology, Presentation Cryoair Whole Body Cryotherapy Chambers, Germany, Jul. 2017, 52 Pages. |
| Medline, Body Temperature Norms, 2 pages (Year: 2019). |
| Mekawy et al., “Influence of Electro-lipolysis on Lipid Profile and Central Obesity in Obese Premenopausal Women” Bull. Fac. Ph. Th. Cairo Univ., vol. 17, No. (1), dated Jan. 2012, pp. 59-68. |
| Mettler J.A., et al., “Low-Frequency Electrical Stimulation With Variable Intensity Preserves Torque,” Journal of Electromyography and Kinesiology: Official Journal of the International Society of Electrophysiological Kinesiology 42:49-56, Oxford: Elsevier, England (Oct. 2018). |
| Mogyoros, I., et al., “Strength-Duration Properties of Human Peripheral Nerve,” Brain 119(Pt 2):439-447, Oxford University Press, England (Apr. 1996). |
| Moon, Chi-Woong“Study on the Pulsed Electromagnetic Fields Effect of Adipocyte Decomposition” Final Report of a Middle-grade Researcher Support Project, Inje University, 2017. |
| Morrissey. M., “Electromyostimulation from a Clinical Perspective,” Sports Medicine 6(1):29-41, Springer International, New Zealand (Aug. 1988). |
| Mulholland, R.S., “Synergistic Multi-polar Radiofrequency and Pulsed Magnetic Fields in the Non-Invasive Treatment of Skin Laxity and Body Contouring,” 4 pages. |
| Mustafa, B., “Design and Construction of a Low Cost dsPIC Controller Based Repetitive Transcranial Magnetic Stimulator TMS,” Journal of medical systems 34(1):15-24, Kluwer Academic/Plenum Publishers, United States (2010). |
| Nadler, S.F., et al., “The Physiologic Basis and Clinical Applications of Cryotherapy and Thermotherapy for the Pain Practitioner,” Pain Physician, 7(3):395-399, American Society of Interventional Pain Physicians, United States (Jul. 2004). |
| Nassab, R., “The Evidence Behind Noninvasive Body Contouring Devices,” Aesthetic Surgery Journal, 35(3):279-293, Oxford University Press, England (Mar. 2015). |
| National Institute of Neurological Disorders and Stroke, Epilepsy Information Page, www.ninds.nih.gov/disorders/epilepsy/epilepsy.htm, pp. 1-6 (Feb. 1, 2016). |
| Neotonus, Inc., K973096 510(k) Summary, Neotonus Model 1000 Muscle Stimulator System, All pages (Jun. 1998). |
| Neotonus, Inc., K973929 510(k) Summary and FDA Correspondence, Neotonus, All pages (May 1998). |
| Neuro Star, TMS Therapy, Bringing Hope to Patients with Depression, 2013, 6 Pages. |
| Neurosoft, Ivanovo, Since 1992, Magnetic Stimulator, NEURO-MS, Technical Manual, Neurosoft Ltd, Ivanovo, Russia, 2006, 67 Pages. |
| Nexstim NBS System, Navigated Brain Stimulation, Noninvasive, direct cortical mapping, 2012, 5 Pages. |
| Neyroud, D., et al., “Comparison of Electrical Nerve Stimulation, Electrical Muscle Stimulation and Magnetic Nerve Stimulation to Assess the Neuromuscular Function of the Plantar Flexor Muscles,” European journal of applied physiology 115(7):1429-1439, Springer-Verlag, Germany (2015). |
| Nielsen, J.F., et al., “A New High-frequency Magnetic Stimulator With an Oil-cooled Coil,” Journal of Clinical Neurophysiology 12(5):460-467, Lippincott Williams & Wilkins, United States (Sep. 1995). |
| Non Final Office Action dated Jun. 23, 2017, in U.S. Appl. No. 15/473,390, Schwarz, T., et al., filed Mar. 29, 2017. |
| Novickij, V., et al., “Compact Microsecond Pulsed Magnetic Field Generator for Application in Bioelectronics,” Elektronika ir Elektrotechnika 19(8):25-28 (Oct. 2013). |
| Novickij, V., et al., “Design and Optimization of Pulsed Magnetic Field Generator for Cell Magneto-Permeabilization,” Elektronika ir Elektrotechnika (Electronics and Electrical Engineering) 23(2):21-25 (Apr. 2017). |
| Novickij, V., et al., “Magneto-Permeabilization of Viable Cell Membrane Using High Pulsed Magnetic Field,” IEEE Transactions on Magnetics 51(9), All pages (Sep. 2015). |
| Novickij, V., et al., “Programmable Pulsed Magnetic Field System for Biological Applications,” IEEE Transactions on Magnetics 50(11):5 (Nov. 2014). |
| NPF Electroapparat, Amplipulse-5Br Manual, allegedly accessed on Nov. 18, 2020, All pages. |
| Nuerosoft Ltd., “Neurosoft—Neuro-MS Transcranial Magnetic Simulator Technical Manual,” All pages (Nov. 2014). |
| Obsluze, N.K., Usage Instructions, User's Manual, Device for high-induction magnetic stimulation of type designation: Saluter Moti, 2016,88 Pages. |
| Oliveira, P. De., et al., “Neuromuscular Fatigue After Low-and Medium-frequency Electrical Stimulation in Healthy Adults,” Muscle & Nerve 58(2):293-299, John Wiley & Sons, United States (Aug. 2018). |
| Operating Manual: Magstim® 2002, P/N 3001-23-04, The Magstim Company Limited, Mar. 18, 2005, 34 pages. |
| Operating Manual: Magstim D702 Coil, MOP06-EN, Revision 01, The Magstim Company Limited, Feb. 2012, 14 Pages. |
| Operating Manual: Magstim Magstim 2002, MOP01-EN, Revision 01, The Magstim Company Limited, Sep. 2011, 25 Pages. |
| Operating Manual: Magstim, Magstim Alpha Coil Range, MOP11-EN, Revision 01, Oct. 2012, 18 Pages. |
| Operating Manual: Magstim, Magstim Bistim2, MOP02-EN, Revision, The Magstim Company Limited, Sep. 1, 2011, 27 Pages. |
| Operating Manual, MAGSTIM, Model 200, P/N 3001-01, Double 70mm, Remote Coil, P/N 3190-00, The Magstim Company Limited, 2006, 32 pages. |
| Operating Manual: Magstim R, 2nd, Generation Coil Family, 3100-23-02, Magstim Coils, The Magstim Company Limited, Nov. 2002, 14 Pages. |
| Operating Manual, Magstim R Air-Cooled Double 70mm Coil System, 1600-23-04, The Magstim Company Limited, 1999, 18 Pages. |
| Operating Manual: Magstim R, Bistim System, P/N 3234-23-01, The Magstim Company Limited, Nov. 2004, 30 Pages. |
| Operating Manual: Magstim R, Coils & Accessories, 1623-23-07, Magstim Coils & Accessories, May 2010, 24 Pages. |
| Operating Manual: Magstim, RAPID2, P/N 3576-23-09, The MAGSTIM Company LTD, Nov. 2009, 61 Pages. |
| Operator's Manual: BTL Emsculpt, BTL Industries Ltd, United Kingdom, 2018, 35 pages. |
| Operator's Manual: BTL, HPM-6000U, BTL Industries Ltd, United Kingdom, Dec. 2016, 36 pages. |
| Otte, J.S., et al., “Subcutaneous Adipose Tissue Thickness Alters Cooling Time During Cryotherapy,” Archives of Physical Medicine and Rehabilitation, 83(11):1501-1505, W.B. Saunders, United States (Nov. 2002). |
| Pain Management Technologies, “Pain Management Technologies Product Catalog,” (2012). |
| Papimi, For Scientific Research, Pap lon Magnetic Inductor, Presentation, Magnetotherapeutic Device, Nov. 2009, 61 Pages. |
| Pascual-Leone, A., et al., “Handbook of Transcranial Magnetic Stimulation,” Chapters 1-4, 58 pages, Arnold Publishers, England (2002). |
| Periso SA, CTU mega Diamagnetic Pump 20: Device For Diamagnetic Therapy, CTU Mega 20 Manual, dated Aug. 28, 2019, 44 pages, Pazzallo Switzerland. |
| Photograph, Alleged Photograph of Components of a Salus Talent Pop Double Device with An Alleged Manufacture date of Nov. 14, 2012, 1 page. |
| Physiomed, MAG-Expert, Physiomed Manual, Dec. 19, 2012. |
| Physiomed, Physiomed Mag-Expert, Physiomed Catalog, pp. 81-83. |
| Platil, A., “Magnetopneumography Using Optical Position Reference,” Sensor Letters 11(1):69-73, ResearchGate (2013). |
| Podebradsky. K., et al., Clinical study of high-inductive electromagnetic stimulator SALUS talent, 2010, 8 pages. |
| Pohanka, J., et al., “An Embedded Stereovision System: Aspects of Measurement Precision,” 12th Biennial Baltic Electronics Conference, pp. 157-160 (Oct. 2010). |
| Polk, C., “Therapeutic Applications of Low-Frequency Sinusoidal and Pulsed Electric and Magnetic Fields,” The Biomedical Engineering Handbook, vol. 1, 2000, Second edition, CRC Press LLC, pp. 1625-1636. |
| Polkey M.I., et al., “Functional Magnetic Stimulation of the Abdominal Muscles in Humans,” American Journal of Respiratory and Critical Care Medicine 160(2):513-522, American Thoracic Society, United States (Aug. 1999). |
| Polkey, M.I., et al., “Quadriceps Strength and Fatigue Assessed by Magnetic Stimulation of the Femoral Nerve in Man,” Muscle Nerve 19(5):549-555, John Wiley & Sons, United States, (May 1996). |
| Pollegen, K200545, Legend Pro DMA, Indications for use, dated Oct. 20, 2021,11 pages. |
| Pollogen, Trilipo MED Procedure, Brochure, dated Apr. 7, 2021, 76 pages. |
| Pollogen, Maximus Non-invasive body shaping System, User Manual, dated May 1, 2012, 44 pages, http://download.lifvation.com/Maximus_UserManual.pdf. |
| Porcari, J.P., et al., “Effects of Electrical Muscle Stimulation on Body Composition, Muscle Strength, and Physical Appearance,” Journal of Strength and Conditioning Reasearch 16(2):165-172, Human Kinetics Pub., United States (May 2002). |
| Porcari, J.P., et al., “The Effects of Neuromuscular Electrical Stimulation Training on Abdominal Strength, Endurance, and Selected Anthropometric Measures,” Journal of Sports Science and Medicine 4(1):66-75, Dept. of Sports Medicine, Turkey (Mar. 2005). |
| Pribula, O. and Fischer, J., “Real Time Precise Position Measurement Based on Low-Cost CMOS Image Sensor,” IEEE, 5 pages (2011). |
| Pribula, O., et al., “cost-effective Image Acquisition System for Precise Pc-based Measurements,” Przeglad Elektrotechniczny (Electrical Review), 259-263, 2011. |
| Pribula, O., et al., “Optical Position Sensor Based on Digital Image Processing: Magnetic Field Mapping Improvement,” Radioengineering 20 (1):55-60, (Apr. 2011). |
| Pribula, O., et al., “Real-Time Video Sequences Matching Spatio-Temporal Fingerprint,” IEEE, 911-916 (Jun. 2010). |
| Prouza, O., et al., “High-Intensity Electromagnetic Stimulation Can Reduce Spasticity in Post-Stroke Patients,” International Journal of Physiotherapy 5(3):87-91 (2018). |
| Prouza, O., “Ex-Post Analyza Spot Rebnich Dani,” All pages, (2008). |
| Prouza, O., “Targeted Radiofrequency Therapy for Training Induced Muscle Fatigue—Effective or Not?,” International Journal of Physiotherapy 3(6):707-710 (Dec. 2016). |
| PTAB-IPR2021-00296, U.S. Pat. No. 10,493,293, Petition for Inter Partes Review, Dec. 14, 2020, 117 pages. |
| PTAB-IPR2021-00312, U.S. Pat. No. 10,478,634, Petition for Inter Partes Review, Dec. 14, 2020, 108 pages. |
| PTAB-PGR2021-00015, U.S. Pat. No. 10,709,895, Petition for Post-Grant Review, Dec. 14, 2020, 140 pages. |
| PTAB-PGR2021-00016, U.S. Pat. No. 10,709,895, Petition for Post-Grant Review, Dec. 14, 2020, 144 pages. |
| PTAB-PGR2021-00017, U.S. Pat. No. 10,632,321, Petition for Post-Grant Review, Dec. 14, 2020, 121 pages. |
| PTAB-PGR2021-00018, U.S. Pat. No. 10,632,321, Petition for Post-Grant Review, Dec. 14, 2020, 140 pages. |
| PTAB-PGR2021-00020, U.S. Pat. No. 10,695,575, Petition for Post-Grant Review, Dec. 14, 2020, 112 pages. |
| PTAB-PGR2021-00021, U.S. Pat. No. 10,695,575, Petition for Post-Grant Review, Dec. 14, 2020, 117 pages. |
| PTAB-PGR2021-00022, U.S. Pat. No. 10,709,894, Petition for Post-Grant Review, Dec. 14, 2020, 119 pages. |
| PTAB-PGR2021-00023, U.S. Pat. No. 10,709,894, Petition for Post-Grant Review, Dec. 14, 2020, 136 pages. |
| PTAB-PGR2021-00024, U.S. Pat. No. 10,695,576, Petition for Post-Grant Review, Dec. 14, 2020, 136 pages. |
| PTAB-PGR2021-00025, U.S. Pat. No. 10,695,576, Petition for Post-Grant Review, Dec. 14, 2020, 135 pages. |
| Publication of Medical Device Manufacturing Approval of Salus-TALENT-Pro, approval date Mar. 11, 2014, 39 pages. |
| Quick Start Manuals, Magstim Super Rapid Plus Quick Start, Aalto TMS Laboratory, Aalto School of Science, 2013, 7 Pages. |
| Radakovic T. and Radakovic N., “The Effectiveness of the Functional Magnetic Stimulation Therapy in Treating Sciatica Syndrome,” Open Journal of Therapy and Rehabilitation 3(3):63-69 (2015). |
| Reaction User Manual, Viora, Doc No. MK-004 A, 2008, 53 Pages. |
| Reshaping the Future of Your Practice, Cool sculpting, A Revolution in Aesthetic Fat Reduction, 2011, 10 Pages. |
| Riehl., M., “Chapter 3: TMS Stimulator Design” The Oxford Handbook of Transcranial Stimulation, Wasserman, E.M., ed., pp. 13-23, Oxford University Press, 26 pages, United Kingdom (2008). |
| Roots, H., and Ranatunga, K.W., “An Analysis of the Temperature Dependence of Force, During Steady Shortening at Different Velocities, in (Mammalian) Fast Muscle Fibres,” Journal of Muscle Research and Cell Motility 29(1):9-24, Springer, Netherlands (Jun. 2008). |
| Ruiz-Esparza, J. and J. Barba Gomez., “The Medical Face Lift: A Noninvasive, Nonsurgical Approach to Tissue Tightening in Facial Skin Using Nonablative Radiofrequency,” Dermatologic Surgery 29(4):325-332, Williams & Wilkins, United States (Apr. 2003). |
| Russian excerpt of Werner, R., Magnetotherapy, Pulsating energy resonance therapy, 41-67 (Jun. 2007). |
| Rutkove, S., “Effects of Temperature on Neuromuscular Electrophysiology,” Muscle & Nerve 24(7):867-882, John Wiley & Sons, United States (Jul. 2001). |
| Salus Talent, a Vertice and Talos, Drott, 6 pages. |
| Salus Talent, Deep Penetrating Electro-Magnetic Stimulator, CR Technology, 4 pages. |
| Salus Talent, Deep Penetrating Electro-Magnetic Stimulator, Rehabilitation Medical Company, New choice, new satisfaction, Talent, 4 pages. |
| Salus Talent, Electro Magnetic Stimulator, CR Technology, 9 Pages. |
| Salus Talent Pop, The first sales bill, Authorization No. 20120221-41000096-66667961, 2 pages, (Feb. 2012). |
| Salus Talent Pro, Specification, 2 pages. |
| Salus, Talent Pro, The Birth of Salus Talent Pro inspired by 10 Years of Experience, Specification, Rehabilitation Medical Company, Slimon, 2 pages. |
| Salus, Talent Pro, The World's 1st Development 3 Tesla, 2Channel Magnetic field Therapy, Slimon , 10 pages. |
| Salus Talent-A, Remed, User Guide, High Intensity Electro Magnetic Field Therapy, 2017, 37 pages. |
| Salus Talent-Pop Double, 1 page. |
| Salus-Talent, Device for Deep Electromagnetic Stimulation, Nowosc, Fizjoterapia, 6 Pages. |
| Sargeant, A.J., “Effect of Muscle Temperature on Leg Extension Force and Short-term Power Output in Humans,” European Journal of Applied Physiology and Occupational Physiology 56(6):693-698, Springer Verlag, Germany (Sep. 1987). |
| Schaefer, D.J., et al., “Review of Patient Safety in Time-Varying Gradient Fields,” Journal of Magnetic Resonance Imaging 12:20-29, Wiley-Liss, United States (Jul. 2000). |
| Scientific & Clinical Background of (MP)2®—A synergy between Multi polar RF and Pulsed Magnetic Field developed by Venus Concept. Prof. Yeouda Edoute M.D, Ph, D, 2 pages. |
| Shimada, Y., et al., “Effects of therapeutic magnetic stimulation on acute muscle atrophy in rats after hindlimb suspension,” Biomedical Research 27(1):23-27, Biomedical Research Foundation, Japan (Feb. 2006). |
| Silinskas, V., et al., “Effect of Electrical Myostimulation on the Function of Lower Leg Muscles,” Journal of strength and Conditioning Research 31(6):1577-1584, Human Kinetics Pub, United States (2017). |
| Sport-Elec S.A., K061914 510(k) Summary, Sport-Elec, All pages (Jul. 2007). |
| Sport-Elec S.A., K081026 510(k) Summary, Sport-Elec, All pages (Nov. 2008). |
| Stallknecht, B., et al., “Are Blood Flow and Lipolysis in Subcutaneous Adipose Tissue Influenced by Contractions in Adject Muscles in Humans?,” American Journal of Physiology. Endocrinology and Metabolism 292(2):E394-E399, American Physiological Society, United States (Feb. 2007). |
| Starbelle, PEMF Shape, Webpage, dated Feb. 10, 2020, 3 pages, available at http://www.starbelle.cn/info/PEMFShape.html. |
| Stedman, T.L., “Aponeurosis—Apparatus,” in Stedman's Medical Dictionary, 27th Edition, Pugh, M.B., ed., pp. 113-114, Lippincott Williams & Wilkins, Baltimore, MD (2000). |
| Stevens, J.E., et al., “Neuromuscular Electrical Stimulation for Quadriceps Muscle Strengthening After Bilateral Total Knee Arthroplasty: A Case Series,” Journal of Orthopaedic and Sports Physical Therapy 34(1):21-29, Williams And Wilkins, United States (Jan. 2004). |
| Struppler, A., et al., “Facilitation of Skilled Finger Movements by Repetitive Peripheral Magnetic Stimulation (RPMS)—A New Approach In Central Paresis.,” NeuroRehabilitation 18(1):69-82, IOS Press, Amsterdam (2003). |
| Struppler, A., et al., “Modulatory Effect of Repetitive Peripheral Magnetic Stimulation on Skeletal Muscle Tone in Healthy Subjects: Stabilization of the Elbow Joint,” Experimental Brain Research 157(1):59-66, Springer Verlag, Germany (Feb. 2004). |
| Suarez-Bagnasco, D., et al., “The Excitation Functional for Magnetic Stimulation of Fibers.,” Annual International Conference of the IEEE Engineering in Medicine and Biology Society, IEEE Engineering in Medicine and Biology Society, Annual International Conference, 2010:4829-4833, IEEE, United States (2010). |
| Swallow, E.B., et al., “A Novel Technique for Nonvolitional Assessment of Quadriceps Muscle Endurance in Humans,” Journal of Applied Physiology 103(3):739-746, American Physiological Society, United States (Sep. 2007). |
| Szecsi, J., et al., “A Comparison of Functional Electrical and Magnetic Stimulation for Propelled Cycling of Paretic Patients,” Archives of Physical Medicine and Rehabilitation 90(4):564-570, W.B. Saunders, United States, (Apr. 2009). |
| Szecsi, J., et al., “Force-pain Relationship in Functional Magnetic and Electrical Stimulation of Subjects With Paresis and Preserved Sensation,” Clinical Neurophysiology 121(9):1589-1597, Elsevier, Netherlands, (Sep. 2010). |
| Taylor, J.L, “Magnetic Muscle Stimulation Produces Fatigue Without Effort,” Journal of Applied Physiology (1985) 103(3):733-734, American Physiological Society, United States, (Sep. 2007). |
| Tesla Stym, Iskra Medical, Tone the inner muscle with FMS Functional Magnetic Stimulation, 2013, 4 pages. |
| The Burn Centre Care, Education, 3 pages, printed from internet Nov. 13, 2017. |
| The Magstim Company Ltd, K080499 510(k) Summary, Magstim Double 70mm Air Film Coil, All pages (Dec. 2008). |
| The Magstim Company Ltd., K130403 510(k) Summary, Magstim D702 coil, All pages (Aug. 2013). |
| Thermi Launches Arvati, powered by Thermi, with newest advances in True Temperature Controlled Radiofrequency Technology, 5 pages (2018). |
| Thermi Smooth TM 250, High Power Temperature Controlled Radio Frequency, Thermi Aesthetics, 25 pages. |
| Thompson, M.T., “Inductance Calculation Techniques—Part II: Approxmiations and Handbook Methods,” Power Control and Intelligent Motion, 11 pages (Dec. 1999) http://www.pcim.com/. |
| Thompson, M.T., “Inductance Calculation Techniques—Part II: Classical Methods,” Power Control and Intelligent Motion, 25(12):40-45, (Dec. 1999) http://www.pcim.com/. |
| Tomek, J., et al., “Magnetopneumography—Incorporation of optical position reference,” Journal of Electrical Engineering, All pages (2012). |
| Torbergsen, T., “Abstracts of the International Course and Symposium in Single Fibre EMG and Quantitative EMG Analysis. Tromsø, Norway, Jun. 4-8, 1984,” Muscle & Nerve 9(6):562-574, John Wiley & Sons, United States (Jul.-Aug. 1986). |
| Trifractional FAQs, http://pollogen.lifvation.com/FAQ/TriFractional%20FAQs.pdf, Aug. 2011 (4pages). |
| TSEM Med Swiss SA, Diamagnetic Therapy: A Revolutionary Therapy, CTU Mega 20 Catalogue, dated 2016, 24 pages, Lugano Switzerland. |
| Turley, J., “Agilent Technologies Announces 30 MHz Function/Arbitrary Waveform Generators with Unparalleled Signal Accuracy,” Elec. Eng'g J., URL: (Aug. 4, 2010), 8 pages. |
| Ultra Slim Professional, The very best body Contouring, Wardphotonics LLC, 2018, 16 pages. |
| Unique Multi-Treatment Platform For, Feminine Health, Venus Fiore, 12 pages. |
| Urban, J., “Magnetotherapy and Physiotherapy,” 40 pages. |
| Uro Diagnostic Clinic, Now in UDC, Automated pelvic floor muscle training, QRS International AG, 16 Pages. |
| U.S. Appl. No. 60/848,720, inventor Burnett, D., filed Sep. 30, 2006 (Not Published). |
| U.S. Appl. No. 62/331,060, inventor Schwarz, T., filed May 3, 2016 (Not Published). |
| U.S. Appl. No. 62/331,072, inventor Schwarz, T., filed May 3, 2016 (Not Published). |
| U.S. Appl. No. 62/331,088, inventor Schwarz, T., filed May 3, 2016 (Not Published). |
| U.S. Appl. No. 62/333,666, inventor Schwarz, T., filed May 9, 2016 (Not Published). |
| U.S. Appl. No. 62/351,156, inventor Schwarz, T., filed Jun. 16, 2016 (Not Published). |
| U.S. Appl. No. 62/357,679, inventor Schwarz, T., filed Jul. 1, 2016 (Not Published). |
| U.S. Appl. No. 62/440,905, inventors Schwarz, T. et al., filed Dec. 30, 2016 (Not Published). |
| U.S. Appl. No. 62/440,912, inventors Schwarz, T. et al., filed Dec. 30, 2016 (Not Published). |
| U.S. Appl. No. 62/440,922, inventor Schwarz, T., filed Dec. 30, 2016 (Not Published). |
| U.S. Appl. No. 62/440,936, inventor Schwarz, T., filed Dec. 30, 2016 (Not Published). |
| U.S. Appl. No. 62/440,940, inventor Schwarz, T., filed Dec. 30, 2016 (Not Published). |
| U.S. Appl. No. 62/441,805, inventor Prouza, O., filed Jan. 3, 2017 (Not Published). |
| U.S. Appl. No. 62/786,731, inventor Schwarz, T., filed Dec. 31, 2018 (Not Published). |
| User Guide: Mag Venture, Magpro family, MagPro R30, MagPro R30 with MagOption, MagPro X100, MagPro X100 with MagOption, MagPro software v.5.0, US-edition, MagPro family User Guide, 2010, 52 Pages. |
| User Guide, Salus Talent Pro, REMED, High Intensity Electro magnetic Field Therapy-2 Channel, 2017, Version M-1.0.0, 45 pages. |
| User Guide, Salus Talent, REMED, High Intensity Electro magnetic Field Therapy, Version. M-1.0.0, 2017, 40 pages. |
| User's Manual: BTL-6000, Super Inductive System Elite, BBTL Industries Ltd, United Kingdom, Sep. 2016, 36 pages. |
| User Manual: Electro-magnetic Stimulator, Salus-Talent, Version 1.00, Rehabilitation Medical Company, 2013, 34 Pages. |
| User Manual: Regenetron PRO, System Information, Regenetron PRO User Manual, Nov. 2014, 7 Pages. |
| Vance, C., et al., “Effects of Transcutaneous Electrical Nerve Stimulation on Pain, Pain Sensitivity, and Function in People with Knee Osteoarthritis,” Physical Therapy 92:898-910 (2012). |
| Vanquish Operator's Manual, BTL, 2012, 48 Pages. |
| Venus Concept Ltd., VenusFreeze MP2, User Manual, dated Jun. 2012, 46 pages. |
| Venus Concept Ltd., VenusViva, User Manual, dated Aug. 2013, 51 pages. |
| Venus Legacy, Featuring LiftFX and SculptFX, Venus Concept, Delivering the Promise, 24 pages. |
| Venus Legacy, User Manual International, 2009, Venus Concept, 49 pages. |
| Venus Swan, Experience the Difference, Venus Concept, Delivering the Promise, http://www.medicom.cz/UserFiles/File/LekarskeNenue/020Swan%20EN.pdf, 2 pages (Apr. 2016). |
| VenusFreeze, Experience the Energy, Venus Concept, Delivering the Promise, 2 pages. |
| Verges S., et al., “Comparison of Electrical and Magnetic Stimulations to Assess Quadriceps Muscle Function,” Journal of Applied Physiology (1985) 106(2):701-710, American Physiological Society, United States, (Feb. 2009). |
| Wada, K., et al., “Design and Implementation of Multi-Frequency Magnetic Field Generator Producing Sinusoidal Current Waveform for Biological Researches,” IEEE, 9 pages (2016). |
| Wanitphakdeedecha, R., et al., “Treatment of Abdominal Cellulite and Circumference Reduction With Radiofrequency and Dynamic Muscle Activation” Journal of Cosmetic and Laser Therapy 17(5):246-251, Informa Healthcare, England (2015). |
| Ward, A.R. and Shkuratova, N., “Russian Electrical Stimulation: The Early Experiments, ” Physical therapy 82(10):1019-1030, Oxford University Press, United States (2002). |
| Wasilewski, M.L., Academy of Aesthetic and Anti-Aging Medicine, Application of magnetic fields with deep stimulation in the fight against local obesity of lower limbs, BTL, 2012, 4 pages. |
| Web MD, what is normal body temperature? 3 pages, printed Mar. 4, 2019. |
| Weight to volume aluminum, 2 pages printed from internet Sep. 25, 2018. |
| Weight to volume copper, 2 pages printed from internet Sep. 25, 2018. |
| Weiss, R.A., et al., “Induction of Fat Apoptosis by a Non-Thermal Device: Mechanism of Action of Non-Invasive High-Intensity Electromagnetic Technology in a Porcine Model,” Lasers in surgery and medicine 51(1):47-53, Wiley-Liss, United States (Jan. 2019). |
| Weng, O., “Electromagnetic Activation of the Calf Muscle Pump,” UMI Dissertation Publishing (2014). |
| Weyh, T., et al., “Marked Differences in the Thermal Characteristics of Figure-of-eight Shaped Coils Used for Repetitive Transcranial Magnetic Stimulation,” Clinical Neurophysiology 116(6):1477-1486, Elsevier, Netherlands (Mar. 2005). |
| Woehrle, J., et al., “Dry Needling and its Use in Health Care—A Treatment Modality and Adjunct for Pain Management,” Journal of Pain & Relief 4(5):1-3, (Aug. 2015). |
| Yacyshy, A.F., et al., “The Inclusion of Interstimulus Interval Variability Does Not Mitigate Electrically-evoked Fatigue of the Knee Extensors,” European Journal of Applied Physiology 120(12):2649-2656, Springer-Verlag, Germany (Sep. 2020). |
| Z Wave, Instructions for Use, Zimmer Aesthetic Division, Version 5, 44 pages. |
| Zao Okb Ritm, Electroneurostimulants, Transdermal Scenar-NT Instructions, All Pages (Nov. 2013). |
| Zao Okb Ritm, Percutaneous Electrical Stimulators With Individual Biofeedback Dosing Impact on Reflex Zones, All pages (2017). |
| Zelickson, B., et al., “Cryolipolysis For Noninvasive Fat Cell Destruction: Initial Results From a Pig Model,” Dermatologic Surgery 35(10):1462-1470, Hagerstown, MD Lippincott, Williams & Wilkins, United States (Oct. 2009). |
| ZELTIQ System User Manual—Print and Binding Specifications, ZELTIQ Aesthetics, Inc, Mar. 2011, 88 pages. |
| Zerona, Reveal your True Shape, Product Fact Sheet, 3 pages. |
| Zerona R-Z6 by Erchonia, Specifications, Retrieved from the Internet: (www.myzerona.com), 2015, 1 page. |
| Zhang, G., et al., “A Method of Nerve Electrical Stimulation by Magnetic Induction, ” Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2009:622-625, IEEE, United States (2009). |
| Zhi-De, D., “Electromagnetic Field Modeling of Transcranial Electric and Magnetic Stimulation: Targeting, Individualization, and Safety of Convulsive and Subconvulsive Applications,” Academic Commons (2013). |
| Zhu, Y., et al., “Magnetic Stimulation of Muscle Evokes Cerebral Potentials by Direct Activation of Nerve Afferents: A Study During Muscle Paralysis,” Muscle & Nerve 19(12):1570-1575, John Wiley & Sons, United Sates (Dec. 1996). |
| Letter from US Food & Drug Administration to Johari Digital Healthcare Ltd. regarding K212866, attaching 510(K) summary; Dec. 3, 2022; 17 pages. |
| Lanzamiento de BTL Vanquish ME en Argentina, BTL Aesthetics Int., 2018 at 0:33, 0:34; available at: https://www.youtube.com/watch?v=5yb5IMmN76Q&ab_channel=BTLAestheticsInt, downloaded Jul. 12, 2023; 2 pages. |
| Magneris—ASTAR—magnetotherapy unit, 2010 at 1:16, 1:35, 1:40 and 1:50 available at: https://www.youtube.com/watch?v=1001LYnaq4g&ab_channel=Astar-aparatydlafizjotera, downloaded Jul. 12, 2023; 2 pages. |
| Notice of Allowance dated Jul. 21, 2021 for U.S. Appl. No. 17/087,850 (pp. 1-8). |
| Notice of Allowance dated May 6, 2020 for U.S. Appl. No. 16/194,800 (pp. 1-8). |
| Notice of Allowance dated Oct. 8, 2019 for U.S. Appl. No. 15/603,162 (pp. 1-8). |
| Notice of Allowance dated Mar. 24, 2021 for U.S. Appl. No. 17/087,850 (pp. 1-8). |
| Office Action dated Aug. 15, 2019 for U.S. Appl. No. 16/194,800 (pp. 1-12). |
| Office Action dated Jul. 10, 2020 for U.S. Appl. No. 15/678,915 (pp. 1-9). |
| Office Action dated Jun. 14, 2021 for U.S. Appl. No. 15/786,303 (pp. 1-13). |
| Office Action dated Jun. 28, 2021 for U.S. Appl. No. 16/727,458 (pp. 1-11). |
| Office Action dated Oct. 7, 2019 for U.S. Appl. No. 15/678,915 (pp. 1-8). |
| Venus, Venus legacy marca argentina, Oct. 14, 2014, 20 pages. |
| File History for U.S. Appl. No. 62/812,123, to Caselino et al., filed Feb. 28, 2019. |
| File History for U.S. Appl. No. 62/884,099, to Caselino et al., filed Aug. 7, 2019. |
| File History for U.S. Appl. No. 62/908,741, to Caselino et al., filed Oct. 1, 2019. |
| Zimmer MedizinSysteme GmbH, K192940 510(k) Summary, Cooltone, 14 pages (Nov. 2019). |
| Bios s.r.l., K201239 510(k) Summary, NuEra Tight Family, EMS Model, 9 pages (Dec. 2020). |
| Remed Co., Ltd., K202031 510(k) Summary, Talent-Pro Electromagnetic Stimulator, 11 pages (May 2021). |
| Zimmer MedizinSysteme GmbH, K203488 510(k) Summary, emField, 9 pages (Feb. 2021). |
| Lutronic Corporation, K213748 510(k) Summary, CoreLevee, 8 pages (Oct. 2022). |
| Zimmer MedizinSysteme GmbH, K220601 510(k) Summary, CoolTone, 11 pages (Apr. 2022). |
| Nanjing Vishee Medical Technology Co., Ltd., K222875 510(k) Summary, MagGraver F200, 12 pages (Mar. 2023). |
| Storz Medical Ag, K203710 510(k) Summary, Storz Medical Magnetolith Muscle Stimulator, 7 pages (May 2021). |
| Beijing ADSS Development Co., Ltd., K231318 510(k) Summary, Electromagnetic Stimulator Device (Models: EM Contouring and Tesla Duet), 11 pages (Jul. 2023). |
| Shenzhen KeLiTongDa Industrial Co., Ltd., K231136 510(k) Summary, Fitness Belt (Model: KLT-07), 3 pages, (Jun. 2023). |
| Nanjing Vishee Medical Technology Co., Ltd., K230767 510(k) Summary, Pelvic Floor Muscle Stimulator, 7 pages (Sep. 2023). |
| Venus Concept Ltd., K111670 510(k) Summary, Venus Freeze (MP)2, 6 pages (Mar. 2012). |
| Venus Concept Ltd., K140629 510(k) Summary, Venus Swan (MP)2 System, 7 pages (Jun. 2014). |
| Venus Concept Ltd., K111784 510(k) Summary, Venus Swan System, 5 pages (Oct. 2011). |
| Venus Concept Ltd., K143554 510(k) Summary, Venus Legacy CX, 6 pages (Aug. 2015). |
| Venus Concept Ltd., K182094 510(k) Summary, Family of Venus RF Systems—Heal, 7 pages (May 2018). |
| Venus Concept Ltd., K191528 510(k) Summary, Venus Legacy Pro Device, 9 pages (Sep. 2019). |
| Venus Concept Ltd., K191065 510(k) Summary, Venus Viva Device, 12 pages (Apr. 2020). |
| Venus Concept Ltd., K201164 510(k) Summary, Venus Viva MD Device, 9 pages (Jun. 2020). |
| Venus Concept Ltd., K201461 510(k) Summary, Family of Venus RF Systems—Venus Freedom, 8 pages (Oct. 2021). |
| Venus Concept Ltd., K232192 510(k) Summary, Venus Versa Pro System, 11 pages (Sep. 2023). |
| InMode Ltd., K210877 K10(k) Summary, Evolve System with the T3 Applicator, 18 pages (Oct. 2023). |
| InMode Ltd., K231495 K10(k) Summary, The Evolve System with the Transform Applicator, 9 pages (Oct. 2023). |
| InMode Ltd., K191855 K10(k) Summary, EmFace Device, 10 pages (Oct. 2019). |
| Super Inductive System Seat, leaflet, 2 pages (2021). |
| Super Inductive System Seat, User's Manual, 20 pages (2019). |
| Number | Date | Country | |
|---|---|---|---|
| 20230226368 A1 | Jul 2023 | US |
| Number | Date | Country | |
|---|---|---|---|
| 62440922 | Dec 2016 | US | |
| 62440905 | Dec 2016 | US | |
| 62357679 | Jul 2016 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 17752316 | May 2022 | US |
| Child | 18181777 | US | |
| Parent | 17090560 | Nov 2020 | US |
| Child | 17752316 | US | |
| Parent | 16827330 | Mar 2020 | US |
| Child | 17090560 | US | |
| Parent | 15601719 | May 2017 | US |
| Child | 16827330 | US |
