Claims
- 1. A compound of the formula ##STR7## wherein A is N--B wherein B is R.sub.1 or COR.sub.2 wherein R.sub.1 is hydrogen,
- a C.sub.1 -C.sub.4 alkyl or an Ar--Z-- group wherein Ar is aryl and Z is a bond or a C.sub.1 -C.sub.4 alkylene and R.sub.2 is a--CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Z group;
- R is hydrogen or a C.sub.1 -C.sub.4 alkyl; and
- X and Y are each independently hydrogen, nitro or amino, with the proviso that one of X and Y is hydrogen and one of X and Y is other than hydrogen; and pharmaceutically acceptable salts thereof.
- 2. A compound of claim 1 wherein Y is nitro and X is hydrogen.
- 3. A compound of claim 1 wherein Y is amino and X is hydrogen.
- 4. A compound of claim 1 wherein X is nitro and Y is hydrogen.
- 5. A compound of claim 1 wherein X is amino and Y is hydrogen.
- 6. A method of inhibiting ACE in a patient in need thereof comprising administering to said patient an effective ACE inhibitory amount of a compound of claim 1.
- 7. A method of claim 6 wherein the patient is suffering from hypertension.
- 8. A method of claim 6 wherein the patient is suffering from chronic congestive heart failure.
- 9. A pharmaceutical composition comprising an effective ACE inhibitory amount of a compound of claim 1 in admixture or otherwise in association with one or more pharmaceutically acceptable carriers or excipients.
Parent Case Info
This is a division, of application Ser. No. 08/164,047, filed Dec. 8, 1993, U.S. Pat. No. 5,389,628 which is a division of application Ser. No. 08/046,326, filed Apr. 12, 1993, U.S. Pat. No. 5,308,841, issued May 3, 1994; which is a division of application Ser. No. 07/979,029, filed Nov. 20, 1992, now abandoned; which is a division of application Ser. No. 07/905,494, filed Jun. 25, 1992, U.S. Pat. No. 5,208,230, issued May 4, 1993; which is a continuation of application Ser. No. 07/777,625, filed Oct. 23, 1991, now abandoned; which is a continuation-in-part of application Ser. No. 07/633,572, filed Dec. 21, 1990 now abandoned, herein incorporated by reference.
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Divisions (4)
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Number |
Date |
Country |
Parent |
164047 |
Dec 1993 |
|
Parent |
46326 |
Apr 1993 |
|
Parent |
979029 |
Nov 1992 |
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Parent |
905494 |
Jun 1992 |
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Continuations (1)
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Date |
Country |
Parent |
777625 |
Oct 1991 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
633572 |
Dec 1990 |
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