Claims
- 1. A peptide capable of forming an amphipathic helix, said peptide having the sequence Asp-Trp-.alpha.Nal-Lys-Ala-Phe-.alpha.Nal-Asp-Lys-.alpha.Nal-Ala-Glu-Lys-.alpha.Nal-Lys-Glu-Ala-Phe.
- 2. A synthetic high density lipoprotein which comprises a peptide capable of forming an amphipathic helix, said peptide having the sequence: Asp-Trp-.alpha.Nal-Lys-Ala-Phe-.alpha.Nal-Asp-Lys-.alpha.Nal-Ala-Glu-Lys-.alpha.Nal-Lys-Glu-Ala-Phe.
- 3. The lipoprotein of claim 2 wherein the phospholipid is phosphatidylcholine, dimyristyl phosphatidyl chlorine or dipalmitoyl phosphatidylcholine.
- 4. A therapeutic composition useful in the treatment and prevention of atherosclerosis which comprises the synthetic lipoprotein of claim 2, in combination with a pharmaceutically acceptable carrier.
- 5. A method of treatment or prevention of atherosclerosis which comprises administering to a host in need of such treatment an effective amount of a syntheic lipoprotein comprising a peptide having the sequence: Asp-Trp-Leu-Lys-Ala-Phe-Tyr-Asp-Lys-Val-Ala-Glu-Lys-Leu-Lys-Gly-Ala-Phe; bound to a phospholipid.
- 6. A method of treatment or prevention of atherosclerosis which comprises administering to a host in need of such treatment an effective amount of a synthetic lipoprotein comprising a peptide having the sequence: Asp-Trp-.alpha.Nal-Lys-Ala-Phe-.alpha.Nal-Asp-Lys-.alpha.Nal-Ala-Glu-Lys-.alpha.Nal-Lys-Glu-Ala-Phe; bound to a phospholipid.
- 7. A method of treatment or prevention of atherosclerosis which comprises administering to a host in need of such treatment an effect amount of a synthetic lipoprotein comprising a peptide having the sequence: Asp-Trp-Leu-Lys-Ala-Phe-Tyr-Asp-Lys-Val-Ala-Glu-Lys-Leu-Lys-Gly-Ala-Phe-Pro-Asp-Trp-Leu-Lys-Ala-Phe-Tyr-Asp-Lys-Val-Ala-Glu-Lys-Leu-Lys-Gly-Ala-Phe; bound to a phospholipid.
FIELD OF THE INVENTION
The present invention relates to novel peptides; in particular, it relates to novel peptides useful in the treatment and prevention of atherosclerosis. The invention described herein was made in the course of a work under a grant or award from the Department of Health and Human Services. The U.S. Government is entitled to a nonexclusive, royalty-free license.
Non-Patent Literature Citations (4)
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Sparrow et al., Peptides Eds, Rich & Gross, pp. 253-256 (1981). |
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Segrest et al., Jour. Biol. Chem. 258: 2290-2295 (1983). |