Claims
- 1. A compound of the formula ##STR41## wherein R.sub.1 ' is substituted or unsubstituted lower alkyl with the substituents selected from the group consisting of hydroxy, halogen, or aryl; and
- Z'is H, lower alkyl, ##STR42## wherein R.sub.3 and R.sub.4 are H, substituted or unsubstituted lower alkyl with the substituents selected from 1 to 3 aryl groups.
- 2. The compound of claim 1 wherein said compound is rac.-2-acetamido-3-[3-[(1,1-dimethylethoxy)carbonyl]phenyl]propanoic acid.
- 3. The compound of claim 1 wherein said compound is rac.-2-acetamido-3-[4-[2-(1,1-dimethylethoxy)-2-oxoethyl]phenyl]propanoic acid.
- 4. The compound of claim 1 wherein said compound is rac.-2-acetamido-3-[4-[1,1-difluoro[2-(1,1-dimethylethoxy)-2-oxoethyl]phenyl]propanoic acid.
- 5. The compound of claim 1 wherein said compound is (S) -2-[[(1,1-dimethylethoxy)carbonyl ]-amino]-3-[4-[3-( 1,1-dimethylethoxy) -3-oxopropyl]phenyl]propanoic acid.
- 6. The compound of claim 1 wherein said compound is (S)-alpha-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[2-(1,1-dimethylethoxy)-2-oxoethyl]-benzenepropanoic acid.
- 7. The compound of claim 1 wherein said compound is rac.-2-acetamido-3-[3-[2-(1,1-dimethylethoxy)-2-oxoethyl]benzene]propanoic acid.
- 8. The compound of claim 1 wherein said compound is 3-[4-(2-benzyloxy-2-oxoethyl)phenyl]propanoic acid.
- 9. A compound of the formula: ##STR43## wherein one of A' or B' is a group of the formula: ##STR44## and the other of A' or B' is H wherein R.sub.0 is H or F, R.sub.1 is H, substituted or unsubstituted lower alkyl with the substitutents selected from the group consisting of hydroxy, halogen and aryl, and s is an integer from 1-2;
- R' is H, substituted or unsubstituted lower alkyl with the substituents selected from 1 to 3 aryl groups; Z' is H, lower alkyl, --NH.sub.2, ##STR45## wherein R.sub.3 and R.sub.4 are H, substituted or unsubstituted lower alkyl with the substituents selected from 1 to 3 aryl groups.
- 10. The compound of claim 9 wherein said compound is rac.-2-acetamido-3-[3-[2-(1,1-dimethyl-ethoxy)-2-oxoethyl]benzene]propanoic acid benzyl ester.
- 11. The compound of claim 9 wherein said compound is (S)-alpha-[[(1,1-dimethylethoxy)-carbonyl]amino]-4-[2-(1,1-dimethylethoxy)-2-oxoethyl]benzenepropanoic acid methyl ester.
- 12. The compound of claim 9 wherein said compound is rac.-2-acetamido-3-[4-[2-(1,1-dimethylethoxy)-2-oxoethyl]phenyl]propanoic acid benzyl ester.
- 13. The compound of claim 9 wherein said compound is rac.-2-acetamido-3-[4-[1,1-difluoro-[2-(1,1-dimethylethoxy)-2-oxoethyl]]phenyl]propanoic acid benzyl ester.
- 14. The compound of claim 9 wherein said compound is 1,1-dimethylethyl 3-[4-(2-benzyloxy-2-oxo-ethyl) phenyl]propanoate.
- 15. A compound of the formula: ##STR46## wherein A', B', and R are as in claim 9 and R.sub.8 is H or lower alkyl.
- 16. A compound of the formula: ##STR47## wherein A', B', and R are as in claim 9 and R.sub.8 is H or lower alkyl.
- 17. A compound of the formula ##STR48## wherein R' and Z' are as in claim 9.
- 18. The compound of claim 17 wherein said compound is (S)-4-carboxymethyl-alpha-[[(1,1-dimethylethoxy) carbonyl]amino]benzenepropanoic acid methyl ester.
- 19. The compound of claim 17 wherein said compound is 1,1-dimethylethyl 4-(carboxymethyl)-phenylpropanoate.
- 20. The compound of claim 17 wherein said compound is rac.-2-acetamido-3-[3-(carboxymethyl)phenyl]propanoic acid benzyl ester.
RELATED U.S. APPLICATION DATA
This is a division of application Ser. No. 07/865,431 filed Apr. 9, 1992, now U.S. Pat. No. 5,296,608 which is a divisional of Ser. No. 07/732,435 filed Jul. 18, 1991, now U.S. Pat. No. 5,182,263, which is a continuation of Ser. No. 07/311,872, filed Feb. 21, 1989, which is a continuation-in-part of Ser. No. 07/185,228, filed Apr. 25, 1998, both now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5055481 |
Inukai et al. |
Oct 1991 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0189305 |
Jul 1986 |
EPX |
Non-Patent Literature Citations (8)
Entry |
Bodanszky et al., J. Med. Chem. 21, 1030-1035 (1978). |
Marseigne, et al., Journal of Medicinal Chemistry, 32:445 (1989). |
Wanner et al., Journal of Medicinal Chemistry, 23:85 (1980). |
Yuki et al., Chem. Pharm. Bull. 19 (8) pp. 1664-1668 (1971). |
Cleland, Journal of Organic Chemistry 34(3) pp. 744-747 (1969). |
Caldwell, et al., J.C.S. Perkin I, 2 pp. 495-505 (1980). |
Rudinger, Peptide Hormones, Parsons (Ed) J. Park Press. Baltimore, pp. 1-7 (1976). |
Bergeson et al., Chem. Abstract vol. 105 No. 209396q (1986). |
Divisions (2)
|
Number |
Date |
Country |
Parent |
865431 |
Apr 1992 |
|
Parent |
732435 |
Jul 1991 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
311872 |
Feb 1989 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
185228 |
Apr 1988 |
|