Claims
- 1. A compound of the formula:
- 2. A compound of the formula:
- 3. A compound of the formula:
- 4. A compound of the formula:
- 5. A compound of the formula
- 6. A method to inhibit tumor growth in an animal in need of such inhibition, comprising administering a compound selected from the group consisting of a compound of claim 1,
DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg, DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Nig-Arg, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Oic-Arg, Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-DTic-ChG, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Nc7G-Arg, and DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg.
- 7. A method to inhibit tumor growth in an animal in need of such inhibition, comprising administering a compound selected from the group consisting of a compound of claim 2,
DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg, DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Nig-Arg, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Oic-Arg, Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-DTic-ChG, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Nc7G-Arg, and DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg.
- 8. A method to inhibit tumor growth in an animal in need of such inhibition, comprising administering a compound selected from the group consisting of a compound of claim 3,
DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg, DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Nig-Arg, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Oic-Arg, Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-DTic-ChG, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Nc7G-Arg, and DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg.
- 9. A method to inhibit tumor growth in an animal in need of such inhibition, comprising administering a compound selected from the group consisting of a compound of claim 4,
DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg, DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Nig-Arg, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Oic-Arg, Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-DTic-ChG, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Nc7G-Arg, and DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg.
- 10. A method to inhibit tumor growth in an animal in need of such inhibition, comprising administering a compound selected from the group consisting of a compound of claim 5,
DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg, DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Nig-Arg, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Oic-Arg, Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-DTic-ChG, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Nc7G-Arg, and DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg.
- 11. A method to induce apoptosis, comprising administering a compound selected from the group consisting of a compound of claim 1,
DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg, DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Nig-Arg, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Oic-Arg, Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-DTic-ChG, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Nc7G-Arg, and DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg.
- 12. A method to induce apoptosis, comprising administering a compound selected from the group consisting of a compound of claim 2,
DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg, DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Nig-Arg, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Oic-Arg, Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-DTic-ChG, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Nc7G-Arg, and DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg.
- 13. A method to induce apoptosis, comprising administering a compound selected from the group consisting of a compound of claim 3,
DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg, DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Nig-Arg, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Oic-Arg, Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-DTic-ChG, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Nc7G-Arg, and DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg.
- 14. A method to induce apoptosis, comprising administering a compound selected from the group consisting of a compound of claim 4,
DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg, DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Nig-Arg, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Oic-Arg, Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-DTic-ChG, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Nc7G-Arg, and DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg.
- 15. A method to induce apoptosis, comprising administering a compound selected from the group consisting of a compound of claim 5,
DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DIgl-Oic-Arg, DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Nig-Arg, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Oic-Arg, Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-DTic-ChG, DArg-Arg-Pro-Hyp-Gly-Igl-Ser-DF5F-Nc7G-Arg, and DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg.
Parent Case Info
[0001] The present application claims priority to U.S. Provisional Patent application serial No. 60/097,210, filed Aug. 20, 1998 and U.S. Provisional Patent application serial No. 60/141,169, filed Jun. 25, 1999.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60097210 |
Aug 1998 |
US |
|
60141169 |
Jun 1999 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09378019 |
Aug 1999 |
US |
Child |
10035662 |
Dec 2001 |
US |