Claims
- 1. A method of inhibiting growth of a fungus in a host that is infected with a fungus comprising administering to said host a composition comprising an acceptable carrier, and a compound selected from the group consisting of formulae 1a, 1b, 1c, 1d, and 1e, wherein said method, said composition is administered to the host for a time and under conditions effective to inhibit growth of said fungus; and wherein the structures of said formulae are as follows:
- 2. The method according to claim 1 wherein said fungus is Cryptococcus neoformans.
- 3. The method according to claim 2 wherein said host is a mammal.
- 4. The method according to claim 3 in which said mammal is a human.
- 5. The method according to claim 3 in which said composition is administered to said human by parenteral means.
- 6. The method according to claim 3 in which said composition is administered topically to said human.
- 7. The method according to claim 4 in which said composition is administered intravenously to said human.
- 8. The method according to claim 4 in which said active ingredient is administered in a suppository inserted in said host.
- 9. The method according to claim 3 in which said composition is administered to said mammal by parenteral means.
- 10. The method according to claim 3 in which said composition is administered topically to said mammal.
- 11. The method according to claim 3 in which said composition is administered intravenously to said mammal.
- 12. The method according to claim 3 in which said composition is administered in a suppository inserted in said mammal.
- 13. The method according to claim 3 wherein said mammal is infected systematically with Cryptococcus neoformans.
- 14. The method according to claim 3 wherein the epidermis of said mammal is infected with Cryptococcus neoformans.
- 15. The method according to claim 10 wherein said carrier is selected from the group consisting of a water-and-oil emulsion, petrolatum, mineral oil, a moisturizer, and a solubilizer.
- 16. The method according to claim 6 wherein said carrier is selected from the group consisting of a water-and-oil emulsion, petrolatum, mineral oil, a moisturizer, and a solubilizer.
- 17. The method of claim 10 in which said carrier contains a fragrance.
- 18. The method of claim 16 in which said carrier contains a fragrance.
Parent Case Info
This application claims the benefit of provisional applications 60/070,879 filed Jan. 9, 1998 and 60/091,705 filed Jul. 3, 1998.
Government Interests
This research was funded in part by Outstanding Investigator Grant CA44344-01-09 awarded by the National Cancer Institute, DHHS. The United States government may have certain rights to this invention.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/US99/00418 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO99/35164 |
7/15/1999 |
WO |
A |
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5504191 |
Pettit |
Apr 1996 |
A |
Provisional Applications (2)
|
Number |
Date |
Country |
|
60/070879 |
Jan 1998 |
US |
|
60/091705 |
Jul 1998 |
US |