Claims
- 1. A composition for inhibiting large cell formation comprising an effective amount of a plasma protein in which the polarity of an amino group of an amino acid residue constituting the plasma protein is chemically modified into a negative moiety and a pharmaceutically acceptable carrier.
- 2. The composition of claim 1, wherein said amino group of an amino acid residue is modified by a dicarboxylic anhydride.
- 3. The composition according to claim 2, wherein said dicarboxylic anahydride is maleic anahydride or succinic anhydride.
- 4. The composition according to claim 1, wherein said plasma protein is a member selected from the group consisting of human serum albumin, human immunoglobulin, human transferrin, human fibrinogen and bovine serum albumin.
Priority Claims (2)
Number |
Date |
Country |
Kind |
1-2574 |
Jan 1989 |
JPX |
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1-18790 |
Jan 1989 |
JPX |
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Parent Case Info
This is a division of application Ser. No. 07/576,439, filed on Sept. 10, 1990, U.S. Pat. No. 5,164,486.
Foreign Referenced Citations (2)
Number |
Date |
Country |
0038667 |
Oct 1981 |
EPX |
1212844 |
Nov 1970 |
GBX |
Non-Patent Literature Citations (2)
Entry |
Jonas et al. Biochemistry vol. 9, No. 24, (1970) pp. 4729-4735. |
Butler et al. Method Enzymol., 25, (1972) pp. 191-199. |
Divisions (1)
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Number |
Date |
Country |
Parent |
576439 |
Sep 1990 |
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