Claims
- 1. An anti-IgM antibody conjugate comprising: a monoclonal antibody which binds selectively to IgM antibody, does not bind to IgG1 or IgG2 antibody, has a G isotype; and a cytotoxic moiety conjugated to said monoclonal antibody.
- 2. The conjugate of claim 1, wherein said monoclonal antibody binds to hybridoma cells producing an IgM antibody.
- 3. The conjugate of claim 1, wherein said monoclonal antibody is produced by rat×rat or rat×mouse hybridoma or progeny of said hybridoma.
- 4. The conjugate of claim 1, wherein said monoclonal antibody is labeled with a detectable label.
- 5. The conjugate of claim 1, wherein the cytotoxic moiety is gelonin.
- 6. A method of killing IgM antibody producing cells comprising contacting said cells with a cytocidally effective amount of the conjugate of claim 5.
- 7. An anti-IgM antibody conjugate comprising: a monoclonal antibody which binds selectively to murine IgM antibody, doe not bind to IgG1 or IgG2 antibody, and has a G isotype; and a cytotoxic moiety conjugated to said monoclonal antibody.
- 8. The conjugate of claim 7, wherein said monoclonal antibody binds to hybridoma cells producing an anti-mouse IgM antibody.
- 9. A The conjugate of claim 7, wherein said monoclonal antibody is labeled with a detectable label.
- 10. The conjugate of claim 2, wherein said monoclonal antibody is produced by a rat×rat or rat×mouse hybridomas or progeny of said hybridomas.
- 11. The conjugate of claim 2, wherein the cytotoxic moiety is gelonin.
- 12. A method of killing murine IgM antibody producing cells comprising contacting said cells with a cytocidally effective amount of the conjugate of claim 7.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of U.S. patent application Ser. No. 08/139,613, filed Oct. 20, 1993, now abandoned which is a continuation of U.S. patent application Ser. No. 07/832,663, filed Feb. 4, 1992, now abandoned, which is a continuation of U.S. patent application Ser. No. 07/515,974, filed Apr. 27, 1990, now abandoned.
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Continuations (2)
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07/832663 |
Feb 1992 |
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08/139613 |
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07/515974 |
Apr 1990 |
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Child |
07/832663 |
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US |
Continuation in Parts (1)
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08/139613 |
Oct 1993 |
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08/192507 |
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