Anti-Inflammatory Polypeptides

Abstract

This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.

Description

Claims

1-2. (canceled)

3. An isolated nucleic acid comprising a sequence encoding a polypeptide having at least 80% sequence identity to SEQ ID NO: 2, wherein amino acid residue (numbered according to the EU index of Kabat) of the polypeptide, which corresponds to residue 32 of SEQ ID NO: 2, is an alanine.

4. The isolated nucleic acid of claim 3, wherein the polypeptide has at least 85% sequence identity to SEQ ID NO: 2.

5. The isolated nucleic acid of claim 3, wherein the polypeptide has at least 90% sequence identity to SEQ ID NO: 2.

6. The isolated nucleic acid of claims 3, wherein the polypeptide has at least 95% sequence identity to SEQ ID NO: 2.

7. The isolated nucleic acid of claim 3, wherein the polypeptide has at least 99% sequence identity to SEQ ID NO: 2.

8. The isolated nucleic acid of claim 3, wherein the polypeptide comprises SEQ ID NO: 2.

9. The isolated nucleic acid of claim 3, wherein the polypeptide consists of SEQ ID NO: 2.

10. The isolated nucleic acid of claim 3, wherein the polypeptide is sialylated.

11. The isolated nucleic acid of claim 3, wherein the polypeptide is not sialylated.

12. An expression vector comprising the nucleic acid of claim 3.

13. A host cell comprising the nucleic acid of claim 3.