Carron et al. Cancer Research 58:1930-1935 (1998). |
A. Nichols, et al., “Antiangiogenic and anticancer activities of the antagonists of integrin αvβ3”, Proc. Am. Assoc. Cancer Res., vol. 38, No. A1389 pp. 206, (Mar., 1997). |
E. Aboud-Pirak, et al., “Inhibition of Human Tumor Growth in Nude Mice by a Conjugate of Doxorubicin With Monoclonal Antibodies to Epidermal Growth Factor Receptor”, Proc. Natl. Acad. Science, vol. 86, pp. 3778-3781, (1989). |
A. Adamis, et al., “Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy”, Amer. Journal of Ophthalmology vol. 118, pp. 445-450, (1994). |
L. Apelgren, et al., “Antitumor Activity of the Monoclonal Antibody-Vinca Alkaloid Immunoconjgate LY203725 (KS1/4-4-Desacetylvinblastine-3-carboxhydrazide) in a Nude Mouse Model of Human Ovarian Cancer”, Cancer Research, vol. 50, 3540-3544, (1990). |
A. Bachmann et al., “Integrin receptor-targeted transfer peptides for efficient delivery of antisense oligodeoxynucleotides”, Journal of Molecular Medicine, vol. 76, No. 2, pp. 126-132 (1998). |
J. Bennett, et al., “Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody”, Proc. Natl. Acad. Science, vol. 80, pp. 2417-2421, (1983). |
S. Bodary et al., “The Integrin β1 Submit Associates with the Vitronectin Receptor αv Subunit to Form a Novel Vitronectin Receptor in a Human Embryonic Kidney Cell Line”, J. Biolog. Chem., vol. 265, pp. 5938-5941, (1990). |
P. Brooks, et al., “Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin”, J. Clin. Invest., vol. 96, pp. 1815-1822, (1995). |
P. Brooks, et al., “Integrin αvβ3 Antagonists Promote Tumor Regression by Inducing Apoptosis of Angiogenic Blood Vessels”, Cell Press, vol. 79, pp. 1157-1164, (1994). |
P. Brooks, et al., “Requirement of Vascular Integrin αvβ3 for Angioenesis”, Science, vol. 264, (1994). |
D. Cheresh, “Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor”, Proceedings of the National Academy of Sciences, vol. 84, No. 18, pp. 6471-6475, (1987). |
E. Choi, et al., “Inhibition of neointimal hyperplasia by blocking αvβ3 integrin with a small peptide antagonist Gpen GRGDSPCA”, J. of Vascular Surgery, vol. 19, No. 1, pp. 125-134, (1994). |
A. Chuntharapai, et al., “Blocking Monoclonal Antibodies to αVβ3 Integrin Ia Present on Human Osteoclasts”,Cell Research, vol. 205, No. 2, (1993). |
S. Crooke, “Therapeutic Applications of Oligonucleotides”, Bio/Technology, vol. 10, pp. 882-886, (1992). |
R. Dillman, et al., “Superiority of an Acid-labile Daunorubican-Monoclonal Antibody Immunoconjugate Compared to Free Drug”, Cancer Research, vol. 48, pp. 6097-6102, (1998). |
M. Doerr, et al., “The Roles of Integrins and Extracellular Matrix Proteins in the Insulin-like Growth I-stimulated Chemotaxis of Human Breast Cancer Cells”, J. Biological Chemistry, vol. 271, No. 5, pp. 2443-2447, (1996). |
J. Fisher, et al., “Inhibition of Osteoclastic Bone Resorption in Vivo by Eshistatin, an Arginyl-Glycyl-Aspartyl (RGD)-Containing Protein”, Endocrinology, vol. 132, pp. 1411-1413, (1983). |
G. Fuller et al., “Fibrinogen”, Methods in Enzymol, vol. 163, pp. 474-485, (1988). |
G. Galfre et al., “Immunochemical Techniques, Methods in Enzymology”, vol. 73, pp. 3-46, (1981). |
M. Ginsberg, et al., “Reduced Surface Expression and Binding of Fibronectin by Thrombin-stimulated Thrombasthenic Platelets”, J. Clin Invest, vol. 71, pp. 619-624, (1983). |
J. Goding, “Antibody Procuction by Hybridomas”, Journal of Immunological Methods, vol. 39, pp. 285-308, (1980). |
G. Gui et al., “In vitro regulation of human breast cancer cell adhesion and invasion via integrin receptors to the extracellular matrix”, British Journal of Surgery, vol. 82, pp. 1192-1196, (1995). |
M. Humphries, et al., “Investigation of the Biological Effects of Anti-Cell Adhesive Synthetic Peptides That Inhibit Experimental Metastasis of B16-F10 Murine Melanoma Cells”, J. Clin Invest., vol. 81, pp. 782-790, (1988). |
E. Hurwitz, et al., “The Covalent Binding of Daunomycin and Adriamycin to Antibodies, with Retention of Both Drug and Antibody Activities”, Cancer Research, vol. 35, pp. 1175-1181, (1975). |
E. Hurwitz, et al., “The Covalent Linking of Two Nucleotide Analogues to Antibodies”, Journal of Med. Chem., vol. 28, pp. 137-140, (1985). |
E. Hurwitz, et al., “Daunomycin-Immunoglobulin Conjugates, Uptake and Activity In Vitro”, Eur. J. Cancer vol. 14, pp. 1213-1220, (1978). |
E. Hurwitz, et al., “Soluble Macromolecules as Carriers for Daunorubicin”, Journal of Applied Biochemistry, vol. 2, pp. 25-35, (1980). |
W. Huse, et al., “Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda”, Science, vol. 246, pp. 1275-1281, (1989). |
D. Johnson, et al., “in vivo antitumor activity demonstrated with squamous carcinoma reactive monoclonal antibody-Vinca immunoconjugates”, Cancer Immunol Immunother, vol. 27, pp. 241-245, (1988). |
I. Kimura, et al., “Production of Tumor Antibody-Neocarzinostatin(NCS) Conjugate and its Biological Activities”, Cancer Immunology and Immunotherapy, vol. 7, pp. 235-242, (1980). |
G. Kohler and C. Milstein, “Continuous cultures of fused cells secreting antibody of predefined specificity”, Nature vol. 256, pp. 495-497, (1975). |
P. Kulkarni, et al., “Covalent Binding of Methotrexate to Immunoglobulins and the Effect of Antibody-linked Drug on Tumor Growth in Vivo”, Cancer Research, vol. 41, pp. 2700-2706, (1981). |
E. Lavie, et al., “Monoclonal antibody L6-daunomycin conjugates constructed to release free drug at the lower pH of tumor tissue”, Cancer Immunology Immunotherapy, pp. 223-230, (1991). |
M. Lehmann, et al., “A Monoclonal Antibody Inhibits Adhesion to Fibronectin and Vitronectin of a Colon Carcinoma Cell Line and Recognizeds the Integrins αvβ3, αvβ5 and αvβ61”, Cancer Research, vol. 54, pp. 2102-2107, (1994). |
Y. Manabe, et al., “Production of a Monoclonal Antibody-Bleomycin Conjugate Utilizing Dextran T-40 and the Antigen-Targeting Cytotoxicity of the Conjugate”, Biochemical and Biophysical Research Communications, vol. 115, No. 3, pp. 1009-1014, (1983). |
D. McIntosh, et al., “Pharmacokinetics and Tissue Distribution of Cisplatin and Conjugates of Cisplatin With Carboxymethyldextran and A5B7 Monoclonal Antibody in CD1 Mice”, Journ. Of Pharmaceutical Sciences, vol. 86, No. 12, pp. 1478-1483, (1997). |
A. Montgomery, et al., “Integrin αvβ3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen”, Proceedings of the National Academy of Science, vol. 91, pp. 8856-8860, (1994). |
S. Morrison, et al., “Chimeric Human Antibody Molecules: Mouse antigen-binding Domains With Humans Constant Region Domains”, Proceeding of the National Academy of Sciences, vol. 81, pp. 6851-6855, (1984). |
B. Mueller, et al., “Antibody Conjugates with Morpholinodoxorubicin and Acid-Cleavable Linkers”, Bioconjugate Chem., vol. 1, pp. 325-330, (1990). |
M. Naramura, et al., “Mechanisms of cellular cytotoxicity mediated by a recombinant antibody-IL2 fusion protein against human melanoma cells”, Immunology Letters, vol. 39, pp. 91-99, (1994). |
H. Niman, et al., “Generation of protein-reactive antibodies by short peptides is an event of high frequency”, Proc. Natl. Acad. Science, vol. 80, pp. 4949-4953, (1983). |
K. Ondrick, et al., “Angiogenesis”, Clinics in Pediatric Medicine and Surgery, vol. 9, No. 1, pp. 186-200, (1992). |
M. Page, et al., “Dawnomycin Targeting To Human Colon Carcinoma Cells Using Drug-Anticea Conjugates”, Proc. Am. Assoc. Cancer Res., vol. 22, p. 211, (1981). |
M. Page, et al., “Drug Targeting With Monoclonal Antibodies”, C.10 Drug Targeting, pp. 933-936 (1981. |
D. Peacock, et al., “Angiogenesis Inhibition Suppresses Collagen Arthritis”, J. Exp. Med. pp. 1135-1138, (1992). |
G. Pietersz, et al., “Immunochemotherapy of a Murine Thymoma with the Use of Idarubicin Monoclonal Antibody Conjugates”, Cancer Research, vol. 48, pp. 926-931, (1988). |
J. Price, et al., “The Use of a Genotypic Marker to Demonstrate Clonal Dominance During the Growth and Metastasis of a Human Breast Carcinoma in Nude Mice”, Int. J. Cancer, pp. 968-971, (1990). |
R. Pytela et al., “Arginine-Glycine-Aspartic Acid Adhesion Receptors”, Methods in Enzymol., vol. 144, pp. 475-489, (1987). |
R. Reisfeld, et al., “Recombinant Antibody Fusion Proteins for Cancer Immunotherapy”, Current Topics in Microbiology 213/III and Immunology, pp. 28-53 (1996). |
S. Rybak, et al., “Humanization of immunotoxins”, Proc. Natl. Acad. Science, vol. 89, pp. 3165-3169, (1992). |
Z. Ruggeri, et al., “Glanzamann thrombasthenia: Deficient binding of von Willebrand factor to thrombin-stimulated platelets”, Proceedings of the National Academy of Sciences, vol. 79, pp. 6038-6041 (1982). |
L. Sastry, et al., “Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies: Construction of a heavy chain variable region-specific c DNA library”, Proceedings of the National Academy of Sciences, vol. 86, pp. 5728-5732, (1989). |
M. Sato, et al., “Echistatin Is a Potent Inhibitor of Bone Resorption in Culture”, The Journal of Cell Biology, vol. 111, pp. 1713-1722, (1990). |
R. Seftor, et al., “Role of the αvβ3 integrin in human melanoma cell invasion”, Proc. Natl. Acad. Science, pp. 1557-1561, (1992). |
C. Seigall, et al., “A Single-Chain Immuotoxin Fusion Protein that Cures Human Breast Carcinoma Xenografts in Athymic Mice and Rats”, In Vitro and In Vivo Characterization of BR96 sFv-PE40 (1994). |
M. Smyth, et al., “Selective Enhancement of Antitumor Activity of N-Acetyl Melphalan upon Conjugation to Monoclonal Antibodies”, Cancer Research, vol. 47, pp. 62-69, (1987). |
J. Starling, et al., “In Vivo Antitumor Activity of a Monoclonal Antibody-Vinca Alkaloid Immunoconjugate Directed against a Solid Tumor Membrane Antigen Characterized by Heterogeneous Expression and Noninternalization of Antibody-Antigen Complexes”, Cancer Research, vol. 52, pp. 2965-2972, (1991). |
T. Suzuki, et al., “The Preparation of Mitomycin C, Adriamycin and Daunomycin Covalently Bound to Antibodies as Improved Cancer Chemotherapeutic Agents”, Chem. Pharm. Bull, vol. 29, pp. 844-848, (1981). |
P. Trail, et al., “Antigen-specific Activity of Carcinoma-reactive BR64-Doxorubicin Conjugates Evaluated in Vitro and in Human Tumor Xenograft Models”,Cancer Research, vol. 52, pp. 5693-5700, (1992). |
P. Trail, et al., “Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates”, Science, vol. 261, pp. 212-215, (1993). |
Y. Tsukada et al., “An Anti-α-Fetoprotein Antibody-Daunorubicin Conjugate With a Novel Poly-L-glutamic Acid Derivative as Intermediate Drug Carrier”, J. Natl. Cancer Inst., vol. 73, pp. 721-729, (1984). |
E. Uhlmann, “Antisense Oligonucleotides: A New Therapeutic Principle”, Chemical Reviews, vol. 90, No. 4, pp. 543-584, (1990). |
M. Wagner, et al., “Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1”,Proceeding of the National Academy of Sciences, vol. 78, No. 3, pp. 1441-1445, (1981). |
N. Weidner, “Tumor Angiogenesis: Review of Current Applications in Tumor Prognostication”, Seminars in Diagnostic Pathology, vol. 10, No. 4, Nov. pp. 302-313, (1993). |
J. White, “Integrins as virus receptors”, Current Biology, vol. 3, No. 9, pp. 596-599, (1993). |
S. Wong, “Preparation of Immunotoxins and Other Drug Conjugates For Targeting Theraputics”, Chemistry of Protein Conjugation, CRC Handbook Chapter 11, pp. 267-293, (1991). |
T. Yatohgo, et al., “Novel Purification of Vitronectin from Human Plasma by heparin Affinity Chromatography”, Cell Structure and Function, vol. 13, pp. 281-292, (1988). |