Claims
- 1. A cephalosporanic acid derivative of the formula ##STR26## wherein Q is selected from the group consisting of ##STR27## wherein U is a group OE', wherein E' is selected from the group consisting of hydrogen, a non-toxic, pharmaceutically acceptable salt forming cation and a non-toxic, pharmaceutically acceptable lower alkyl optionally substituted with lower alkanoyloxy, X is selected from the group consisting of acetoxy and S--Q', wherein Q' is selected from the group consisting of a tetrazolyl, triazolyl, imidazolyl or thiadiazolyl optionally substituted with alkyl of 1 to 6 carbon atoms, R.sub.1 is carboxyl methyl optionally transformed into a non-toxic, pharmaceutically acceptable ester or salt and Z.sub.1 " is selected from the group consisting of hydrogen and alkyl of 1 to 6 carbon atoms and ##STR28## wherein Q is as defined above and R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 6 carbon atoms.
- 2. A compound of claim 1 selected from the group consisting of 7-[3-carboxymethyl-1,2,4-oxadiazol-5-yl-acetamido]-3-[1-methyl-tetrazol-5-yl-mercaptomethyl]-3-cephem-4-carboxylic acid and its non-toxic, pharmaceutically acceptable salts and esters.
- 3. A method of killing bacteria comprising contacting bacteria with a bactericidal amount of at least one compound of claim 1.
- 4. An antibacterial composition comprising a bactericidially effective amount of at least one compound of claim 1 and a pharmaceutical carrier.
- 5. A method of combatting bacterial infections in warm-blooded animals comprising administering to warm-blooded animals a bactericidally effective amount of at least one compound of claim 1.
- 6. The method of claim 5 selected from the group consisting of 7-[3-carboxymethyl-1,2,4-oxadiazol-5-yl-acetamido]-3-[1-methyl-tetrazol-5-yl-mercaptomethyl]-3-cephem-4-carboxylic acid and its non-toxic, pharmaceutically acceptable salts and esters.
Priority Claims (1)
Number |
Date |
Country |
Kind |
59524/72 |
Dec 1972 |
GB |
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PRIOR APPLICATION
The present application is a continuation of copending application Ser. No. 571,203 filed Apr. 24, 1975, now abandoned, which in turn is a continuation-in-part of our copending, commonly assigned U.S. patent application Ser. No. 425,798, filed Dec. 18, 1973 now abandoned.
US Referenced Citations (6)
Foreign Referenced Citations (1)
Number |
Date |
Country |
1946638 |
Sep 1970 |
DE |
Non-Patent Literature Citations (1)
Entry |
Merckx, Chemical Abstracts, vol. 44, 4577f (1948). |
Continuations (1)
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Number |
Date |
Country |
Parent |
571203 |
Apr 1975 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
425798 |
Dec 1973 |
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