Claims
- 1. An antibody which specifically reacts with natural killer cell stimulatory factor (NKSF) protein, wherein said protein is capable of inducing the production of gamma interferon in vitro in human peripheral blood lymphocytes (PBL) and is substantially free from association with other proteinaceous materials, said protein comprising (a) a first subunit having an apparent molecular weight of approximately 40 kD under reducing conditions on SDS PAGE and comprising the amino acid sequence of FIG. 1 from amino acids 23 to 328, and (b) a second subunit having an apparent molecular weight of approximately 30-35 kD under reducing conditions on SDS PAGE and comprising the amino acid sequence of FIG. 2 from amino acid 57 to 253, and wherein said antibody is capable of blocking the gamma interferon production inducing activity of such protein.
- 2. The antibody of claim 1, wherein said antibody is poyclonal.
Parent Case Info
This application is a divisional of application Ser. No. 08/858,000, filed May 16, 1997, now abandoned; which was a continuation of application Ser. No. 08/403,013, filed Mar. 13, 1995 and is issued as U.S. Pat. No. 5,648,467; which was a divisional of application Ser. No. 07/584,941, filed Sep. 18, 1990 and issued as U.S. Pat. No. 5,457,038; which was a continuation-in-part of U.S. patent application Ser. No. 07/307,817, filed on Feb. 7, 1989, now abandoned which is a continuation-in-part of U.S. patent application Ser. No. 07/269,945, filed Nov. 10, 1988, now abandoned; all of which are incorporated by reference herein.
The present invention relates to a novel cytokine that stimulates the function of natural killer cells and other cells of the immune system, and to processes for obtaining the factor in homogeneous form and producing it by recombinant genetic engineering techniques.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5811523 |
Trinchieri et al. |
Sep 1998 |
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Continuations (1)
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Number |
Date |
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Parent |
08/403013 |
Mar 1995 |
US |
Child |
08/858000 |
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US |
Continuation in Parts (2)
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Date |
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07/307817 |
Feb 1989 |
US |
Child |
07/584941 |
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US |
Parent |
07/269945 |
Nov 1988 |
US |
Child |
07/307817 |
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US |