Claims
- 1. Substantially pure antigen-specific human glycosylation inhibiting factor (GIF), wherein the antigen is an allergen.
- 2. The antigen-specific GIF of claim 1, wherein the allergen is a venom component.
- 3. The antigen-specific GIF of claim 2, wherein the venom component is a honey bee venom component.
- 4. The antigen-specific GIF of claim 3, wherein the honey bee venom allergen is PLA.sub.2.
- 5. The antigen-specific GIF of claim 4 which has the antigen binding specificity of the antigen-specific human GIF produced by cell line AC5 having ATCC accession number HB 10473.
- 6. The antigen-specific GIF of claim 4 which is produced by cell line AC5 having ATCC accession number HB 10473.
- 7. The antigen-specific GIF of claim 1, wherein the allergen is pollen.
- 8. The antigen-specific GIF of claim 7, wherein the pollen is tree pollen.
- 9. The antigen-specific GIF of claim 8, wherein the tree pollen is cedar pollen.
- 10. The antigen-specific GIF of claim 9 which has the antigen binding specificity of the human antigen-specific GIF produced by cell line 31E9 having ATCC accession number HB 11052.
- 11. The antigen-specific GIF of claim 9 which is produced by cell line 31E9 having ATCC accession number HB11052.
- 12. A pharmaceutical composition comprising immunosuppressive amounts of substantially pitied antigen-specific human GIF and a pharmaceutically inert carrier, wherein the antigen is an allergen.
- 13. The pharmaceutical composition of claim 12, wherein the substantially purified antigen-specific human GIF has the antigen binding specificity of the antigen-specific human GIF produced by cell line AC5 having ATCC accession number HB 10473 or by cell line 31E9 having ATCC accession number HB 11052.
- 14. The pharmaceutical composition of claim 12, wherein the substantially purified antigen-specific human GIF is produced by cell line AC5 having ATCC accession number HB 10473 or by cell line 31E9 having ATCC accession number HB 11052.
Parent Case Info
This application is a divisional application of Ser. No. 08/142,333, filed Jan. 27, 1993, now U.S. Pat. No. 5,565,338, which is a 371 of PCT/US93/04614, filed Jun. 3, 1992, and a continuation-in-part of Ser. No. 07/709,375, filed Jun. 3, 1991, now abandoned, which is a continuation-in-part of Ser. No. 07/533,889, filed Jun. 4, 1990, now abandoned.
Government Interests
This invention was made with Government support under grant numbers AI11202, AI14784, and AI32834 awarded by the National Institutes of Health. The Government has certain rights in the invention.
US Referenced Citations (5)
Non-Patent Literature Citations (11)
Entry |
Iwata et al., "Relationship Between T-Cell Receptors and Antigen-Binding Factors", Journal of Immunology, vol. 143, No. 12, Dec. 15, 1989, pp. 3909-3916. |
Thomas et al., "Glycosylation-Inhibiting Factor From Human T Cell Hybridomas Constructed from Peripheral Blood Lymphocytes of a Bee Venom-Sensitive Allergic Patient", Journal of Immunology, vol. 148, No. 3, Feb. 1, 1992, pp. 729-737. |
Carini et al, "A method to generate antigen-specific suppressor T cells . . . " J. Immunol. Meth. 127(2): 221-233 (Mar. 1990). |
Thomas et al, "Construction of human T cell hybridomas . . . " FASEB J. 4(7):A1937, Abstract #1418 (Apr. 1990). |
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Jardieu et al pp. 595-604 in Immune Regulation by Characterized Polypeptides, (Alan R. Liss, Inc. 1987). |
Akasaki et al. "Immunosuppressive Effects of Glycosylation Inhibiting Factor on the IgE and IgG Antibody Response", J. Immunol. 136(9):3172-3179 (May 1986). |
Iwada et al "Construction of Antigen-Specific Suppressor T Cell Hybridomas . . . " J. Immunol. 141(10): 3270-3277 (Nov. 1988). |
Jardieu et al "Carrier-specific Suppression of Antibody Responses . . . " J. Immunol. 138(5): 1494-1501 (Mar. 1987). |
Ohno et al "Effects of PLA.sub.2 inhibitors on mouse T lymphocytes . . . " Int. Immunol. 1(4): 425, abstract. (1989). |
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Divisions (1)
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Number |
Date |
Country |
Parent |
142333 |
Jan 1993 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
709375 |
Jun 1991 |
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Parent |
533889 |
Jun 1990 |
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