Dorn et al. Pharmacology and Therapeutics, vol. 61, No. 1/2, pp. 155-184 1994. |
Prochiantz, A. Current Opinion in Neurobiology. vol. 6, No. 5, pp. 629-634 1996. |
Farinelli SE, Park DS, Greene LA (1996) Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism. J. Neurosci. 16:2325-2334 (Exhibit 2). |
Fernandes-Alnemri T, Litwack G, Alnemri ES (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein ced-3 and the mammalian IL-1.beta.-converting enzyme J. Biol. Chem. 269:30761-30764 (Exhibit 3). |
Farrari G, Yan CYI, Greene LA (1995) N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J. Neurosci 15:2857-2866 (Exhibit 4). |
Gagliardini V, Fernandez P-A, Lee RKK, Drexler HCA, Rotello RJ, Fishman MC, Yuan J. (1994) Prevention of vertebrate neuronal death by the crmA gene. Science 263:826-828 (Exhibit 5). |
Greene LA (1978) Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. J Cell Biol 78:747-755 (Exhibit 6). |
Hengartner MO, Ellis RE, Horvitz HR (1992) Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature. 356: 494-9 (Exhibit 7). |
Kumar S (1995) Inhibition of apoptosis by the expression of antisense Nedd2. FEBS Letters 368:69-72 (Exhibit 8). |
Kumar S, Knioshita M, Noda M, Copeland NG, Jenkins NA (1994) Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1.beta.-converting enzyme. Genes & Develop 8:1613-1626 (Exhibit 9). |
Lindenboim L, Haviv R, Stein R (1995) Inhibition of drug-induced apoptosis by survival factors in PC12 cells. J. Neurochem 64:1054-1063 (Exhibit 10). |
Miura M, Zhu H, Rotello R, Hartweig EA, Yuan J (1994) Induction of apoptosis in fibroblasts by IL-1.beta.-converting enzyme, a mammalian homolog of the c. elegans cell death gene ced-3. Cell 75:653-660 (Exhibit 11). |
Srinivasan A, Foster LM, Testa M-P, Ord T, Keane RW, Bredesan DE, Kayalar, C (1996) Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis. J Neurosci 16: 5654-5660 (Exhibit 12). |
Troy CM, Brown K, Greene LA, and Shelanski ML (1990). Ontogeny of the neuronal intermediate filament protein, peripherin, in the mouse embryo. Neurosci. 36: 217-237 (Exhibit 13). |
Troy CM, Derossi D, Prochiantz A, Greene LA, Shelanski ML (1996a) Down-regulation of SOD1 leads to cell death by the NO-peroxynitrate pathway. J. Neurosci 16:253-261 (Exhibit 14). |
Troy CM, Greene LA, Shelanski ML (1992). Neurite outgrowth in peripherin-depleted PC12 cells. J Cell Biol 117:1085-1092 (Exhibit 15). |
Troy CM, Shelanski ML (1994) Down-regulation of copper/zinc superoxide dismutase (SOD1) causes apoptotic death in PC12 neuronal cells. Proc. Natl. Acad. Sci. USA 91:6384-6387 (Exhibit 16). |
Troy CM, Stefanis L, Prochiantz A, Greene LA, Shelanski ML (1996b) The contrasting roles of ICE-family proteases and interleukin-1.beta. in apoptosis induced by trophic factor withdrawal and by SOD1 downregulation. Proc Natl Acad Sci USA 93: 5635-5640 (Exhibit 17). |
Troy CM, Stefanis L, Greene L A, Shelanski ML (1996c) Mechanisms of neuronal degeneration: a final common pathway? in Neuronal Regeneration, Reorganization and Repair F. Seil, ed. (New York, NY: Raven Press), pp. 103-112 (Exhibit 18). |
Wang L, Miura M, Bergeron L, Zhu H, Yuan J (1994) Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78: 739-750 (Exhibit 19). |
Yamin, Ting-Ting et al. (1996) "Activation of the Native 45-kDa Precursor Form of Interleukin-1-converting Enzyme," J. Biol. Chem. 271(22): 13273-13282 (Exhibit 20). |
Yuan J, Shahan S, Ledoux S, Ellis HM, Horvitz HR (1993) The c. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1.beta.-converting enzyme. Cell 74: 641-652 (Exhibit 21). |