Claims
- 1. An apparatus for intra-arterial delivery of an oxygen-saturated solution during angioplasty, the oxygen-saturated solution being stabilized upon emergence from the apparatus without associated cavitation comprising:
- a high pressure tubular housing defining a lumen therewithin, the housing having a distal end;
- a coiled spring extending from the tubular housing;
- a jacket including a proximal sleeve section and a distal perforated section that defines exit ports, the proximal sleeve section being located proximate to the distal end of the tubular housing, the proximal sleeve section of the jacket being placed over the coiled spring to prevent leakage of the solution through the coiled spring, while allowing perfusion of the solution through the exit ports of the perforated section, the exit ports being sized to allow the solution to be delivered so that the solution has a composition characterized by a fluid continuum of uniform density upon emergence from an exit port.
- 2. The apparatus of claim 1 further comprising:
- one or more fiberoptics located axially within the tubular housing and the coiled spring, the one or more fiberoptics transmitting radiant energy and receiving reflected energy.
- 3. The apparatus of claim 1 wherein the coiled spring includes a section wherein successive coils of the spring are spaced apart to allow the oxygen-saturated solution to pass through from the exit ports.
- 4. The apparatus of claim 1 further including the oxygen-saturated solution, wherein the solution comprises 5 g % dextrose in water.
- 5. The apparatus of claim 1 further including the oxygen-saturated solution, wherein the solution comprises a normal saline solution.
- 6. The apparatus of claim 1 further including the oxygen-saturated solution, wherein the solution comprises a physiologically-balanced salt solution, the salt solution being selected from a group consisting of a solution of calcium, sodium potassium, magnesium, and mixtures thereof.
- 7. The apparatus of claim 1 further including the oxygen-saturated solution, wherein the solution comprises a buffer selected from the group consisting of a phosphate, a bicarbonate, and mixtures thereof.
- 8. The apparatus of claim 1 further including the oxygen-saturated solution, wherein the solution comprises a physiologically-balanced salt solution and an oncotic agent selected from the group consisting of albumin, hydroxyethyl starch, and mixtures thereof.
- 9. The apparatus of claim 1 further including the oxygen-saturated solution, wherein the solution comprises a balanced salt solution and a perfluorochemical.
- 10. An apparatus for delivering a gas-supersaturated liquid from a source of gas into a site within an environment with a low concentration of the gas in relation to that of the source, comprising:
- a high pressure tubular housing defining a lumen therewithin;
- a guide wire axially disposed within the lumen, the guide wire and the lumen defining therebetween an annular space,
- a charge of gas-saturated liquid disposed within the annular space to eliminate gas nuclei therefrom, the charge having a composition characterized by a fluid continuum of uniform density;
- the gas-supersaturated liquid emerging from the annular space after passage of the charge, the liquid also being characterized by a fluid continuum of uniform density upon emergence from the annular space so that the gas is transported to a site of interest in a supersaturated state, the gas being liberated therefrom remote from the apparatus without associated bubble formation and cavitation proximate the annular space.
- 11. The apparatus of claim 10 further comprising:
- one or more fiberoptics located axially within the tubular housing, the fiberoptics transmitting radiant energy and receiving reflected energy.
- 12. The apparatus of claim 10 further comprising a coil spring extending from the tubular housing for flexibility so that the apparatus may navigate safely through tortuous passageways.
- 13. An apparatus for intra-arterial delivery of an oxygen-saturated solution without bubble formation and cavitation, comprising:
- a high pressure tubular housing defining a lumen therewithin, the housing having a distal end;
- a coiled spring extending from the tubular housing; and
- a jacket including a proximal sleeve section and a distal perforated section;
- exit ports defined in the distal perforated section, the proximal sleeve section being located proximate to the distal end of the tubular housing, the proximal sleeve section of the jacket being placed over the coiled spring to prevent leakage of the solution to the coiled spring, the exit ports being sized to allow perfusion of the solution through the exit ports, the solution being characterized by a fluid continuum of uniform density upon emergence from the exit ports.
- 14. An apparatus for delivering a gas-supersaturated liquid from a source of gas into a site within an environment with a low concentration of the gas in relation to that of the source comprising:
- a high pressure tubular housing defining a lumen therewithin;
- a guide wire axially disposed within the lumen, the guide wire and the lumen defining therebetween an annular space; and
- the annular space being sized to allow the gas-supersaturated liquid to emerge from the annular space, wherein the liquid is characterized by a fluid continuum of uniform density upon emergence from the annular space.
CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation-in-part of application Ser. No. 273,652, filed Jul. 12, 1994, which is a continuation-in-part of application Ser. No. 152,589, filed Nov. 15, 1993 (now U.S. Pat. No. 5,407,426), which is a continuation-in-part of application Ser. No. 818,045, filed Jan. 8, 1992 (now U.S. Pat. No. 5,261,875), which is a continuation of application Ser. No. 655,078, filed Feb. 14, 1991 (now U.S. Pat. No. 5,086,620). Each of these disclosures is incorporated by reference herein.
US Referenced Citations (59)
Non-Patent Literature Citations (3)
Entry |
"Use of Hyperbaric Oxygen as Oxygen Source in Extracorporeal Oxygenation of Blood", C. Boe, et al; Physiological and Clinical Aspects of Oxygenator Design, ed. by Dawids and Engell; publ. by Elsevier/North-Holland Biomedical Press, Luxembourg, 1976. |
"Cavitation in Gas-Supersaturated Solutions", Edvard A. Hemmingsen; Journal of Applied Physics, vol. 46, No. 1, Jan. 1976. |
"Supersaturated Fluorocarbon as an Oxygen Source", Pieter Stroev, et al; Physiological and Clinical Aspects of Oxygenator Design, ed. by Dawids and Engell; publ. by Elsevier/North-Holland Biomedical Press, Luxembourg, 1976. |
Continuations (1)
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Date |
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655078 |
Feb 1991 |
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Continuation in Parts (3)
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Date |
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273652 |
Jul 1994 |
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Parent |
152589 |
Nov 1993 |
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Parent |
818045 |
Jan 1992 |
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