Patent Application
20200015708
N/A
N/A
The subject matter relates to a gas or chemical concentration identification and/or measurement. It further relates to identifying, detecting, measuring and/or analyzing gas or chemical concentrations using emissions of electrical or electromagnetic energy modified or influenced by gases. It further relates to analyzing spectra of gasses. It additionally relates to analyzing spectra of gasses particularly but not limited to those from human breath.
The following background information may present examples of specific aspects of the prior art (e.g., without limitation, approaches, facts, or common wisdom) that, while expected to be helpful to further educate the reader as to additional aspects of the prior art, is not to be construed as limiting the present invention, or any embodiments thereof, to anything stated or implied therein or inferred thereupon.
Conventionally employed diagnosis of Pulmonary Oxygen Toxicity, PO2T, is difficult due to the commonality of clinical symptoms, such as visual disturbance, ear problems, dizziness, confusion, and nausea may be attributed with many other physical ailments. These conventionally employed solutions can typically be subjective and difficult to diagnose in conditions that are conducive to PO2T. The conventional solution further may require self- diagnosis in the absence of trained personnel in the conditions that are conducive to PO2T. Conventionally employed methods analyze visual acuity, ear problems, dizziness, confusion, and nausea, and are limited in these operating conditions.
Other conditions, such as heart failure and pneumonia, also have similar clinical symptoms such as fluid buildup in the lungs, shortness of breath, and fatigue. Heart failure has several laboratory based measurements that may be made, but there is no definitive diagnostic for pneumonia.
The above described solutions typically do not provide an objective numerical evaluation of blood oxygen levels or damage to the heart or lungs. Further, the above described solutions typically require a skilled evaluator and a learning period for the evaluator. These methods are not amenable to automation, nor to electronic transmission of analysis results, and have the potential for misinterpretation of clinical examinations.
Conventional use of RF signals for the detection of gas(ses) has been limited to systems that use more than two antennas, are confined to specific frequency regions, require high RF energy above human exposure limits, are not performed at atmospheric pressure, or use multiple RF signals to identify spectral regions. Other conventional uses that have embodiments of RF sensors with thermistors require the thermistor for signal calibration. Further, the above solutions do not address the ability to measure gas(ses) of interest specifically for the purposes of health diagnostics in humans.
Conventional RF chemical sensors rely on the combination of inputs, in the form of multiple RF measurements, or RF measurements combined with temperature measurements, for accurate calibration of gas(ses) concentration(s). These methods are not able to accurately detect and/or measure gas(ses) of interest without supplementary sensor input.
Furthermore, conventional methods to diagnose human health conditions have been limited to electrochemical sensors, chemical sensors, trained physicians, X-ray, magnetic resonance, radio tomography, IR imaging, and nanotechnology. Most of these methods must be performed in a clinical setting, or by skilled evaluators. The sensors that are amiable to automation have high specificity to the desired test, and are not readily adaptable.
The accompanying drawings are incorporated in and constitute part of the specification and illustrate various embodiments. In the drawings:
Prior to proceeding to the more detailed description of the present subject matter, it should be noted that, for the sake of clarity and understanding, identical components which have identical functions have been identified with identical reference numerals throughout the several views illustrated in the drawing figures.
The following detailed description is merely exemplary in nature and is not intended to limit the described examples or the application and uses of the described examples. As used herein, the words “example”, “exemplary” or “illustrative” means “serving as an example, instance, or illustration.” Any implementation described herein as “example”, “exemplary” or “illustrative” is not necessarily to be construed as preferred or advantageous over other implementations. All of the implementations described below are exemplary implementations provided to enable persons skilled in the art to make or use the embodiments of the disclosure and are not intended to limit the scope of the disclosure, which is defined by the claims.
The term “or” when used in this specification and the appended claims is not meant to be exclusive; rather the term is inclusive, meaning either or both.
The term “couple” or “coupled” when used in this specification and appended claims refers to an indirect or direct physical connection between the identified elements, components, or objects. Often the manner of the coupling will be related specifically to the manner in which the two coupled elements interact.
The term “directly coupled” or “coupled directly,” when used in this specification and appended claims, refers to a physical connection between identified elements, components, or objects, in which no other element, component, or object resides between those identified as being directly coupled.
The term “operatively coupled,” when used in this specification and appended claims, refers to a physical connection between identified elements, components, or objects, wherein operation of one of the identified elements, components, or objects, results in operation of another of the identified elements, components, or objects.
It is to be understood that the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to “a circuit” includes reference to one or more of such circuits.
It is to be understood that electromagnetic emissions may be, but is not limited to radio frequency (RF) emissions, microwave emissions, millimeter wave emissions and terahertz wave emissions.
The terms and words used in the following description and claims are not limited to the bibliographical meanings, but, are merely used by the inventor to enable a clear and consistent understanding of the invention. Accordingly, it should be apparent to those skilled in the art that the following description of exemplary embodiments of the present invention are provided for illustration purpose only and not for the purpose of limiting the invention as defined by the appended claims and their equivalents.
Furthermore, there is no intention to be bound by any expressed or implied theory presented in the preceding technical field, background, or the following detailed description. It is also to be understood that the specific devices and processes illustrated in the attached drawings, and described in the following specification, are simply examples of the inventive concepts defined in the appended claims. Hence, specific dimensions and other physical characteristics relating to the examples disclosed herein are not to be considered as limiting, unless the claims expressly state otherwise.
The particular embodiments of the present disclosure generally provide devices, apparatuses, and methods directed to identifying, detecting, measuring and/or analyzing gas or chemical concentrations using emissions of electrical or electromagnetic energy modified or influenced by such gases or chemicals.
In particular embodiments, gas or chemical concentrations are measured in a non-contact manner using microwave spectroscopy techniques.
In particular embodiments, the frequency ranges from over 100 Mhz to under 30 Ghz to enable lower cost and or portable electronic control members. In particular embodiments, the high frequency limit is 18 Ghz to enable even lower hardware costs.
In particular embodiments, a characterizing device comprises a set of antennas, one or more circuits disposed to provide electrical energy to antennas, one or more circuits disposed to receive electrical energy from antennas.
In particular embodiments, the characterizing device comprises a means for measuring electrical energy properties from said antennas, which are influenced by characteristic(s) of chemicals within the electrical influence of the antennas.
In particular embodiments, solid state partial pressure sensors are used to measure and determine absolute concentrations of oxygen, nitrogen, and/or carbon dioxide, as well as temperature, including a set of solid-state partial pressure sensors, one or more circuits disposed to provide electrical energy to sensors, one or more circuits disposed to receive electrical energy from sensors which are influenced by characteristics of chemical gasses within the measurement influence of the sensors.
In particular embodiments, the apparatus comprises two antennas, an active RF supply, the control software, low noise amplifiers, RF tuners, RF filters, analog to digital converters, programmable logic device(s), general purpose processor(s) and/or single board computer(s), optional GUI. The apparatus may comprise an optional directional coupler, an optional solid-state oxygen, nitrogen, or carbon dioxide sensors, optional thermistor, and/or optional alarm.
Now in reference to Figures,
In reference to
The antennas 108 and 110 are illustrated as being aligned in a direction which is generally normal to a passage direction of the expirate 122. However, one of the antennas 108, 110 can be disposed at an angle in the plane of
The device 102 can further comprise an optional air intake/evacuation member. In an example, the air intake/evacuation member can be a hollow tubular member 104 that is coupled to the body 144 so as to either deliver air supply to the person 130 or facilitate exit or outlet of the expirate 122. The air intake/ evacuation member 104 can be considered as a ventilation tube. In an example, the air intake/ evacuation member can be at least one check valve 190 to allow air to flow only in one direction, for example as an inlet only. In an example, check valve 190 can be used in a combination with the ventilation tube 122 with the check valve 190 being configured as an air intake and ventilation tube 122 being configured as an air outlet. In an example, the check valve 190 can be used in a combination with the ventilation tube 122 with the check valve 190 being configured as an air outlet and the ventilation tube 122 being configured as the air inlet.
The device 102 can also comprise an optional Faraday Cage 196 configured to shield the receiver from external noise as well as to reduce human exposure to the microwave illumination energy. When Faraday Cage 196 is provided, both the receive antenna 110 and the transmit antenna 108 are encased by the Faraday Cage 196. In a mask embodiment of
The device 102 can be a mask worn by a user. The mask 102 can be any one of a medical mask, a mask used by divers, a mask used by pilots, an amusement-appearing mask worn by children at play, and the like.
In operation, the person 130 receives a supply of air either through the air intake/evacuation member 190 or the air intake/evacuation member 104. The device 102 can be configured so that the supply of air will pass through electromagnetic energy emission or field/wave/spectrum 106. The expirate 122 can be evacuated through either the air intake/evacuation member 190 or the air intake/evacuation member 104. The antennas 108, 110 can be operable to continuously or intermittently transmit/receive emissions of electromagnetic energy.
In reference to
The device 192 is considered to receive a gas flow 174 through the intake member 176 and outlet the gas flow as gas flow 172 through the outlet or evacuation member 154, after the gas flow 174 is influenced by the emissions or field/wave/spectrum 106. Each of the intake member 176 and outlet member 154 can be a hollow tube.
As such, the receive antenna 110 receives transmitted electromagnetic energy emission 106 being influenced by the gas flow. The exemplary electromagnetic energy emission 106 is in a radio frequency (RF) range. Thus, the receive antenna 110 outputs an RF signal representative of the received electromagnetic energy emission 106 influenced by the gas flow.
The antennas 108 and 110 are illustrated as being aligned in a direction which is generally normal to a passage direction of the gas flow 174. However, one of the antennas 108, 110 can be disposed at an angle in the plane of
In operation, the gas flow is received through the intake member 176 and is evacuated through the evacuation member 154 after passing through the electromagnetic energy emission 106. The antennas 108, 110 can be operable to continuously or intermittently transmit/receive electromagnetic energy emission 106. The antennas 108, 110 can be also moved, either manually or with a with the robotic device (not shown) when the antennas 108, 110 are mounted external to the enclosure 193.
In the embodiments of
Furthermore, in the embodiment of
In an embodiment of
The device 352 of
The device 302 or 352 is designed to operate while the RF emissions are activated or inactive.
In a further reference to
A variety of software simulation means are available to generate the gas molecule spectrum enabling identification of its spectral frequency regions of significance or interest which exhibit absorption or reflection at frequency regions significantly differing from the absorption or reflection from other regions, useless regions typically exhibit a variation in absorption or reflection of less than 3dB at 100% concentration. Useful software simulation to apply to generate the spectrum may include Density Function Theory (DFT) models, TD/DFT models, Gaussian98, Amsterdam Density Functional (ADF), MNOVA, Spartan, etc. The spectra to be used in the signature and to be emitted by the transmit antenna may also be found on the internet in spectral libraries, and/or through websites such as www.MassBank.jp.
In a further reference to
The hardware control component 500 includes the above described antenna 108 for transmitting electromagnetic energy emission or field/wave/spectrum 106, the reflected/influenced electromagnetic energy field/wave 586 after the electromagnetic wave emission 106 is passed through the chemical(s) of interest 582 and the receive antenna 110 for receiving/capturing the electromagnetic energy field/wave 586. The electromagnetic wave 106 may or may not be altered through interactions with the chemical(s) of interest 582 as the resulting electromagnetic wave 586.
The hardware/software component 552 and/or hardware component 500 can be configured as comprising one or more circuits.
The apparatus 650 comprises an apparatus 620A configured to perform conversions to and/or from time domain data to frequency domain, as well as to interact with components such as the GUI and/or alarm 622, tuner/filter 687, electromagnetic illumination frequency oscillator 636, and analog to digital converter(s) 638. The apparatus 620A comprises a single or a multi-board computer or controller 692 that communicates with the general-purpose processors 602 that receive signals from the analog to digital converters 638, optional DSP ICs 604, and adjust optional filter settings 687. An optional digital signal processor ICs 604 can send and/or receive signals from the programmable logic device 606 and the general-purpose processors 602 to speed up the math performed in signature comparison algorithms for example. Single Board Computer 692 is also configured to receive optional voltage reference signals from sensors 182A, 182B, 182C and/or thermistor 182D.
The apparatus 650 can be configured as comprising one or more circuits.
An exemplary RF chain can include the illumination frequency oscillator 636, the RF power amplifier 634, the optional directional coupler 632, the transmit antenna 108, the transmitted electromagnetic wave 106, the chemical(s) or chemical mixture 582 of interest, the transmitted electromagnetic wave 586 after interacting with the chemical(s) of interest 656, the receive antenna 110, the low noise amplifier(s) (LNA) 626, the RF tuner(s) 644, the analog to digital converter(s) 638, and the optional filter(s) 687. Using LNA 626, with a noise figure under 2 dB and an FFT size of 16K or greater, a sensitivity level better than −150 dBm in the receiver 650 can be achieved. This sensitivity enables detection of low concentrations of gasses and/or the use of lower illumination energy to achieve an illumination exposure under the level considered hazardous or unacceptable by Government standards. Another method of improving sensitivity is using Non-coherent integration (NCI), wherein a smaller FFT, longer NCI integration time and samples, and/or use of higher illumination power. With improved sensitivity, the FFT size can the reduced and/or the dBm sensitivity level can be reduced. The single or a multi board computer or controller 692 can be configured to control the illumination frequency oscillator's frequency 636 that sends the RF signal to the RF power amplifier 634. The amplified signal is optionally sent to the directional coupler 632 or the transmit antenna 108. An RF directional coupler 632 may be used to acquire the reflected spectral energy of the gas under test while allowing the illumination frequency energy to proceed thru the gas. This allows the low level reflected RF energy to be separated from the high-level illumination energy, enabling a more sensitive measurements of the reflected energy. The electromagnetic wave 106 transmitted from the antenna 108 reacts with the chemical(s)/gas(ses) 582 of interest and is either reflected to the transmit antenna 108 and to the optional directional coupler 632 or an electromagnetic wave 586 after interaction with the chemical(s) or mixture of interest 582 is received by a receive antenna 110. The signal from the receive antenna 110 and/or the optional directional coupler 632 is sent to the low noise amplifier(s) 626 then passed to the RF tuner(s) 644. The RF tuner(s) 644 receive filter settings from filter 687 and pass the resulting signal to the analog to digital converter(s) 638. The digital signal is received by the apparatus 620A to convert time domain data into frequency domain data through the programmable logic device 606. After conversion, the signal is passed to the general-purpose processor 602 and the single or a multi board computer or controller 692. The controller 692 performs any verification using one or more verification signature(s) and can displays the result(s) on the optional GUI display and/or alarm 622.
It is contemplated herewithin that any combination of the components 602, 604, 606, 626, 638, 644, 687, and 692 can be integrated into a single control member integrated into a computer and/or implemented as system on a chip.
An exemplary verification signature tool for acetone could include, but not limited to, the frequency position, shape of the absorption peak, amplitude of the absorption peak, etc. In general, the verification signature (tool) for any chemical, chemical mixture, gas and/or expirate 122 can comprise one or more spectral features, such as 704 and/or 706 and/or 708, as a basis for identifying and/or measurement of concentration(s) of these chemical(s) of interest.
An exemplary approach/method for determining chemical concentration through RF absorption and/or reflection measurements is explained below.
The ability of a specific material or chemical to absorb energy at a particular frequency is given by its loss tangent, tan δ, at that frequency. The loss tangent is tied directly to the permittivity of a material in the following manner. Permittivity can have a real and imaginary component and is expressed as:
∈=∈′−j∈″
Where j is the square root of −1. The loss tangent is then defined by as:
where ω is the angular frequency of the wave, and σ is the free charge conduction the gas(ses) under test. From this, it is clear that the loss tangent response profile is highly frequency dependent, with large values indicating strong absorption at that particular frequency. Additionally, microwave absorption follows the Beer-Lambert relationship:
l=l
o
e
−γa
Where γ is the frequency dependent absorption coefficient, 10 is the initial signal intensity, and x is the path length. The absorption coefficient is given by the Van Vleck-Weisskopf equation:
Where N is the number of molecules per unit distance traveled in medium, uij is the dipole matrix element connecting the upper and lower energy states and v is the energy state transition frequency. The absorption coefficient is therefore linearly dependent on the number of molecules present. Since the absorption coefficient is in the exponent of the Beer-Lambert equation, the relationship between chemical concentration, makeup, or degree of degradation and absorbed microwave energy may appear linear when absorption is measured on a logarithmic scale (e.g. frequency in GHz vs. absorption loss in dB).
The method comprises a step of converting the captured and received electromagnetic energy emission signal from an analog to digital signal that processes the captured digital signal by converting the digital time domain signal to a frequency domain signal in module 1026, comprising digital filter 1034, signal processing 1032 and wavelet de-noising 1030. The signal is then filtered with additional signal processing module 1027, comprising digital filter 1052 and additional signal processing 1054. The processed signal is evaluated and scored according to module 1028 comprising one or more algorithms 1040, a frequency domain algorithm waiting 1050 and a determining/calculating final evaluation score 1028.
In an embodiment, an apparatus and/or a method detects levels of acetone in human expirate. Although acetone is present in exhaled gases, certain levels of Acetone in the human expirate may indicate a heart failure condition. Thus, in an embodiment, an apparatus and/or a method detect a heart failure condition is created.
In an embodiment, an apparatus and/or a method can be used for analysis of medical conditions in humans or animals alike.
In an embodiment, an apparatus and/or a method can be used for analysis of ozone levels in air for safety reasons.
In an embodiment, an apparatus and/or a method can be used for analysis of pollutions levels.
In an embodiment, an apparatus and/or a method can be used for analysis of methane levels.
In an embodiment, an apparatus and/or a method can be used for analysis of hydrazine levels.
In an embodiment, an apparatus and/or a method can be used for analysis organic and non-organic gases.
In an embodiment, the apparatus for measuring and/or analyzing gases can be configured as a wearable apparatus. In an example, a patient equipped with mask 102 can have the control and measurement apparatus configured to be worn on a belt or disposed in a pocket of a garment. In an example, a diver equipped with the mask 102 can have the control and measurement apparatus disposed within the mask or within the diving apparatus.
In an embodiment, the apparatus for measuring and/or analyzing gases can be configured as a portable apparatus. In an example, a patient equipped with mask 102 can have the apparatus configured to be moved for example on a support during patient's movement.
In an embodiment, the apparatus for measuring and/or analyzing gases can be configured as a stationary apparatus. The stationary apparatus can be coupled by wires or wirelessly with the devices 102, 192.
In an embodiment, a single or a multi-board computer or controller 692 can be configured and/or integrated within a mobile communication device, for example such as a mobile phone, an iPad, a tablet and the like.
In an embodiment, a single or a multi-board computer or controller 692 can be configured and/or integrated within a portable hand held device.
In an embodiment, any of the above described embodiments can be implemented or configured as a sensor.
It is to be understood that a substantially identically configured system containing a substantially identical RF and executing in parallel may be used to generate exemplary RF emissions and form or determine an exemplary basis for emission characteristics of all substantially similarly configured devices. Thus, the specific RF generating device response need not be initially analyzed in the RF emission domain to later verify its emission comparison. An exemplary device's resulting RF emission may be previously, currently or later analyzed to determine, verify or predict the expected RF emission response of a different yet substantially identically configured unit. The RF emission may be recorded and later verified against an exemplary emission, and need not be immediately evaluated. The RF emissions may thus be recorded in the time domain for later FFT processing and analysis or comparison/verification in the time and/or frequency domain.
In an embodiment two and only two antennas can be operable.
In an embodiment, three and only three antennas can be operable.
Horn antennas, when used, are pointed toward each other. So too are spiral, dipole/monopole antennas
The optional components to the embodiments of the invention, the solid-state oxygen, nitrogen, and carbon dioxide sensors and the thermistor are used in some embodiments of the invention that require oxygen, nitrogen, and carbon dioxide concentrations for detection, analysis, or quantification purposes. An exemplary embodiment that includes these optional components, in addition to the RF antenna signal measurements, is for a device that measures exhaled breath for the determination of pulmonary oxygen toxicity, in which oxygen, and/or nitrogen, and/or carbon dioxide levels of exhaled breath may change. In this embodiment, the thermistor is used with the solid-state sensor to convert the signal to a concentration measurement. Each solid-state sensor may be used with or without the other sensor(s) in an embodiment.
The embodiments are not predisposed to an orientation of use by the apparatus.
In an embodiment, the RF antenna(s) are exposed to the open environment, with or without the optional solid-state sensors and thermistor.
In an embodiment, the RF antennas can be in a confined space, with or without the optional solid-state sensors and thermistor. The confined space would ideally have EMI shielding, but is optional.
In an embodiment, a mask with two antennas with the solid-state sensors and thermistor are used to detect PO2T of the diver, with a vibrational and acoustic alarm.
In an embodiment, an enclosure with two antennas with the solid-state sensors and thermistor are used to monitor premature infants for PO2T with a visual, and acoustic alarm.
In an embodiment, two antennas are used in a small, ventilated enclosure to detect hydrazine in a space shuttle cabin, with a visual alarm.
In an embodiment, two antennas are placed around a breathing tube on a hand-held device to monitor expirate for human health conditions, including, but not limited to pulmonary oxygen toxicity, heart failure, diabetes, ulcerated colitis, and/or cancer.
In an embodiment, any of the above described apparatus can be configured with a sensitivity below −149 dBm, allowing for lower microwave transmit power to be used to achieve the substantially same spectral measurement and hence substantially same spectrum processing and analysis result as with less sensitive implementations. When the apparatus is configured with such reduced sensitivity, the reduced dBm level of the transmitter creates a correspondingly reduced received spectrum dBm level. This reduced dBm received spectrum level enables a lower microwave exposure to the patient to be within or under Government microwave safe exposure limits for humans. Thus a mask or apparatus incorporating the invention's gas sensing technology in close proximity to patients or hospital personnel is safe to use, lighter in weight as lower power cabling, less RF shielding, no RF shielding, and lower power draw is required. The lower power draw also allows for a smaller battery and/or a lighter weight device in a portable embodiment.
In an embodiment, the microwave energy is absorbed, reflected, and re-emitted at lower frequencies, creating the measured spectral response indicative of a concentration and presence of a specific gas compound's molecule.
In an embodiment, a means such as non-coherent integration can be used to improve the spectrum analysis result by reducing the noise level content relative to emission signal content in the received spectrum. A greater receive sensitivity, reduced illumination power levels, and improved detection accuracy results may thus be effectively achieved by using non-coherent integration, but this may be a trade-off requiring more time for acquisitions and processing, and/or may require additional RF receive channels. Longer Coherent-integration means may also be similarly used to improve sensitivity, reduce illumination power levels, and/or improve detection accuracy results.
In an embodiment, each solid-state sensor may be used with or without the other sensor(s). In this embodiment, RF spectroscopy measurements of gasses that are polar and non-polar in nature is combined. Non-polar molecules, such as oxygen, nitrogen, and carbon dioxide, can be detected with RF spectroscopy to some degree, however, the measurable concentrations of the targeted polar molecules are expected to be several orders of magnitude smaller than the non-polar molecules in some embodiments.
Another advantage of solely using only the RF absorption gas measurement means as opposed to using both the solid-state gas sensor measurement means and also the RF absorption gas measurement means is the reduction in total hardware used. Because the wide variety and range of molecules measurable solely by the RF absorption gas measurement means include those measurable by the solid-state gas sensors, using only the RF absorption gas measurement means may be used without additional gas measurement sensors. However, the optional solid-state sensors may significantly improve measurement speed by simultaneously, quickly and easily measuring the higher composition gases of the bulk gases. Stated another way, these optional solid-state sensors require more space and weight but less computational costs and/or measurement acquisition time to determine gas concentrations than a device constructed which uses the RF absorption gas measurement device alone. However, by utilizing these optional sensors, the apparatus may become more efficient The non-polar molecules, such as oxygen, nitrogen, and carbon dioxide, can be detected without the use of the optional solid-state sensors in some embodiments.
The embodiments are not predisposed to an orientation of use by the apparatus.
In an embodiment, the RF antennas are exposed to the open environment, with or without the optional solid-state sensors and thermistor.
In an embodiment, the RF receive and transmit antennas are not shielded within a Faraday cage.
In an embodiment, the RF antennas are in a confined space, with or without the optional solid-state sensors and thermistor. The confined space would ideally have EMI shielding or comprised of a Faraday cage, but is optional.
In an embodiment, an apparatus for determining a concentration of gasses in a gas mixture comprises a transmit antenna coupled to the at least one microwave generator, the transmit antenna configured to transmit an electromagnetic energy emission spectrum through the gas mixture in a response to a microwave radiation coupled thereto; at least one microwave generator tuned to responsive frequencies of the gas, the at least one microwave generator configured to couple the microwave radiation to the transmit antenna; a receive antenna configured to capture an electromagnetic energy difference between a transmitted electromagnetic energy emission spectrum and an electromagnetic energy emission spectrum being absorbed or reflected by gaseous molecules in the gas mixture; a receiver coupled to the receive and/or transmit antenna, the receiver configured to convert the electromagnetic energy difference, into a digital signal; and a control member configured to process the digital signal in accordance with one or more algorithms, the control member configured to analyze the electromagnetic energy difference and determine concentration(s) of gasses in the gas mixture based on an analysis of the difference.
A feature of this embodiment is that the control member is configured to identify a presence or an absence of a heart failure condition in a subject in a response to measuring concentrations of Acetone, and/or Pentane, and/or Hexane, and/or Propane, and/or NO+, and/or Oxygen, and/or Nitrogen, and/or Carbon Dioxide and computationally combining the concentrations measured into an overall score indicative of a degree of or a probability of the heart failure condition in the subject.
A feature of this embodiment is that the control member is configured to identify a presence or an absence of a Pneumonia condition in a subject in a response to measuring concentrations of gasses Isoprene, and/or Hydrogen Cyanide, and/or Oxygen, and/or Nitrogen, and/or Carbon Dioxide and computationally combining the concentrations measured into an overall score indicative of a degree of or probability of the Pneumonia condition in the subject.
A feature of this embodiment is that the control member is configured to identify a presence or an absence of a Pulmonary Oxygen Toxicity condition in a subject in a response to measuring the concentrations of gasses 3-meythyltridecane, and/or 3-methyltridecane, and/or 5-methylnonane, and/or Oxygen, and/or Nitrogen, and/or Carbon Dioxide and computationally combining the concentrations measured into an overall score indicative of a degree of or probability of the Pulmonary Oxygen Toxicity condition in the subject.
A feature of this embodiment is that the control member is configured to determine a relationship between a concentration of gas compounds.
A feature of this embodiment is that the control member is configured to determine an intensity of compound absorption or reflection spectrum in a form of a calibration curve.
A feature of this embodiment is that the control member is configured to the subject the electromagnetic energy emission spectrum to a Fourier analysis.
A feature of this embodiment is that the microwave generator includes at least one of a microwave synthesizer, a directional coupler, a circulator, and a microwave amplifier connected to an output of the microwave synthesizer.
A feature of this embodiment is that the control member comprises a non-coherent and a coherent integration signal processing to reduce a sensitivity of the apparatus.
A feature of this embodiment is that the sensitivity of the apparatus is below -149 dBm.
A feature of this embodiment is that emitted microwave radiation level is maintained below a Specific Absorption Rate (SAR) mandated in accordance with a predefined standard for a person wearing the apparatus in an intended manner where the apparatus is operable as a measurement device. For example, in USA, FCC limit for public exposure from cellular telephones is an SAR level of 1.6 watts per kilogram (1.6 W/kg).A feature of this embodiment is that the transmit antenna being further configured to receive an electromagnetic energy emission spectrum reflected by the gas mixture, the receiver being further configured to receive electromagnetic energy emission spectrum reflected by the gas mixture and received by the transmit antenna and convert the reflected electromagnetic energy emission spectrum into the digital signal.
In an embodiment, a method is provided for determining a presence or an absence of a medical condition in a patient, the method comprises the steps of passing an electromagnetic field generated by a pair of spaced apparat antennas through an expirate from the patient; measuring at least one of an absorption amplitude, an emission amplitude and a reflection amplitude of the expirate from the patient from the electromagnetic field; converting the at least one of the absorption amplitude, the emission amplitude and the reflection amplitude to an absolute concentration; comparing absolute expirate concentration against a stored value; and determining the presence or the absence of the medical condition based on a results of a comparison of the absolute expirate concentration against the stored value.
A feature of this embodiment is that the step of passing the electromagnetic field comprises a step of generating microwave radiation at one or more frequencies the expirate is most responsive.
A feature of this embodiment is that the step of measuring comprising a step of receiving, with a receiving antenna, a microwave radiation transmitted through the expirate.
A feature of this embodiment is that the step of measuring comprising a step of measuring absorption and/or reflection of the microwave radiation.
In an embodiment, a mask comprises a member; a pair of antennas mounted on a surface of the member or within a thickness thereof in a spaced apart relationship with each other; one or more sensors mounted on or within the member; and a ventilation member coupled to the member.
In an embodiment, an apparatus comprises a mask comprising a member, a pair of antennas mounted on a surface of the member or within a thickness thereof in a spaced apart relationship with each other, one or more sensors mounted on or within the member, and a ventilation member coupled to the body. The apparatus further comprises a control member configured to measure absorption, emission and/or reflection of electromagnetic energy spectrum influenced by gaseous molecules in an expirate, the control member configured to determine concentration of gasses in the expirate based on a measurement of one or more of the absorption, the emission and the reflection of the electromagnetic energy spectrum.
In an embodiment, a method for analyzing gaseous compounds and/or for determining a concentration of gas(es) in a gas mixture comprises the steps of generating a microwave radiation at one or more frequencies the gas mixture is most responsive to; transmitting, with a transmitting antenna, the generated microwave radiation through the gas mixture; receiving, with a receiving antenna, a resulting microwave radiation transmitted through the gas mixture; and measuring absorption and/or reflection of the microwave radiation.
A feature of this embodiment is that measuring of the absorption and/or the reflection of the microwave radiation comprises using a fast Fourier Transform (FFT) spectrum versus an energy response generated, the response subsequently used to calculate gas concentration.
In an embodiment, any of the above described methods can be implemented in the form of software or a computer program stored on a tangible computer-readable non-transitory information storage medium and can be implemented in general-use digital computers that execute the programs using a computer readable storage and/or recording medium. In other words, in the context of this document, a computer readable storage and/or recording medium may be any tangible medium that can contain, or store a program and/or data for use by or in connection with an instruction execution system, apparatus, or device.
Tangible computer readable medium means any physical object or computer element that can store and/or execute computer instructions. Examples of tangible computer readable medium include, but not limited to, a compact disc (CD), digital versatile disc (DVD), blu-ray disc (BD), USB floppy drive, floppy disk, random access memory (RAM), read-only memory (ROM), erasable programmable read-only memory (EPROM), optical fiber, etc. In other words, tangible computer readable medium may be an internal part of the computer, a removable external element coupled to the computer, or unit that is remotely accessible via a wired or wireless network. It should be noted that the tangible computer readable medium may even be paper or other suitable medium in which the instructions can be electronically captured, such as optical scanning. Where optical scanning occurs, the instructions may be compiled, interpreted, or otherwise processed in a suitable manner, if necessary, and then stored in computer memory. Alternatively, tangible computer readable medium may be a plugin or part of a software code that can be included in, or downloaded and installed into a computer application. As a plugin, it may be embeddable in any kind of computer document, such as a webpage, word document, pdf file, mp3 file, etc.
Any combination of one or more computer readable storage medium(s) may be utilized. A computer readable storage medium may be embodied as, for example, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or other like storage devices known to those of ordinary skill in the art, or any suitable combination of computer readable storage mediums described herein. The non-transitory computer-readable recording medium may include program instructions, data files, and data structures, alone or in a combination thereof.
In an embodiment, any of the above described methods can be implemented by a single or multiple algorithms.
Persons of ordinary skill in the art may appreciate that, in combination with the examples described in the embodiments herein, units and algorithm steps can be implemented by electronic hardware, computer software, or a combination thereof. In order to clearly describe the interchangeability between the hardware and the software, compositions and steps of every embodiment have been generally described according to functions in the foregoing description. Whether these functions are performed using hardware or software depends on particular applications and design constraints of the technical solutions. A person skilled in the art may use different methods to implement the described functions for each specific application. However, such implementation should not be considered as beyond the scope of the present invention. As an example, the same circuit capabilities may be made in an ASIC, FPGA, or custom logic device.
Computer program code for carrying out operations for aspects of various embodiments may be written in any combination of one or more programming languages, including an object oriented programming language, such as Java, Smalltalk, C++, or the like, and conventional procedural programming languages, such as the “C” programming language or similar programming languages. In accordance with various implementations, the program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the latter scenario, the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet Service Provider).
It will be understood that various blocks of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks.
Many of the elements described in the disclosed embodiments may be implemented as modules. A module is defined here as an isolatable element that performs a defined function and has a defined interface to other elements. The modules described in this disclosure may be implemented in hardware, software in combination with hardware, firmware, wetware (i.e hardware with a biological element) or a combination thereof, all of which are behaviorally equivalent. For example, modules may be implemented as a software routine written in a computer language configured to be executed by a hardware machine (such as C, C++, Fortran, Java, Basic, Matlab or the like) or a modeling/simulation program such as Simulink, Stateflow, GNU Octave, or Lab VIEWMathScript. Additionally, it may be possible to implement modules using physical hardware that incorporates discrete or programmable analog, digital and/or quantum hardware. Examples of programmable hardware comprise: computers, microcontrollers, microprocessors, application-specific integrated circuits (ASICs); field programmable gate arrays (FPGAs); and complex programmable logic devices (CPLDs). Computers, microcontrollers and microprocessors are programmed using languages such as assembly, C, C++ or the like. FPGAs, ASICs and CPLDs are often programmed using hardware description languages (HDL) such as VHSIC hardware description language (VHDL) or Verilog that configure connections between internal hardware modules with lesser functionality on a programmable device. Finally, it needs to be emphasized that the above mentioned technologies are often used in combination to achieve the result of a functional module.
The chosen exemplary embodiments of the claimed subject matter have been described and illustrated, to plan and/or cross section illustrations that are schematic illustrations of idealized embodiments, for practical purposes so as to enable any person skilled in the art to which it pertains to make and use the same. It will be understood that variations, modifications, equivalents and substitutions for components of the specifically described exemplary embodiments of the disclosed subject matter may be made by those skilled in the art without departing from the spirit and scope of the subject matter as set forth in the appended claims.
When used herein, the terms “adapted” and “configured” mean that the element, component, or other subject matter is designed and/or intended to perform a given function. Thus, the use of the terms “adapted” and “configured” should not be construed to mean that a given element, component, or other subject matter is simply “capable of” performing a given function but that the element, component, and/or other subject matter is specifically selected, created, implemented, utilized, programmed, and/or designed for the purpose of performing the function. It is also within the scope of the present disclosure that elements, components, and/or other recited subject matter that is recited as being adapted to perform a particular function may additionally or alternatively be described as being configured to perform that function, and vice versa. Similarly, subject matter that is recited as being configured to perform a particular function may additionally or alternatively be described as being operative to perform that function.
Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and the present disclosure, and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
Although the subject matter has been described in a combination with RF emissions, the disclosed embodiments will apply to devices emitting microwave emissions, millimeter wave emissions and terahertz wave emissions.
It should be appreciated that reference throughout this specification to “an embodiment” means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. Therefore, it is emphasized and should be appreciated that two or more references to “an embodiment” or “one embodiment” or “an alternative embodiment” in various portions of this specification are not necessarily all referring to the same embodiment or the same variation. Furthermore, the particular features, structures or characteristics may be combined as suitable in one or more embodiments of the invention.
Similarly, it should be appreciated that in the foregoing description of embodiments of the invention, various features are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure aiding in the understanding of one or more of the various inventive aspects. This method of disclosure, however, is not to be interpreted as reflecting an intention that the claimed subject matter requires more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive aspects lie in less than all features of a single foregoing disclosed embodiment. Thus, the independent claims following the detailed description are hereby expressly incorporated into this detailed description.
Any element in a claim that does not explicitly state “means for” performing a specified function, or “step for” performing a specified function, is not to be interpreted as a “means” or “step” clause as specified in 35 U.S.C. § 112, ¶6. In particular, any use of “step of” in the claims is not intended to invoke the provision of 35 U.S.C. § 112, ¶6.
Anywhere the term “comprising” is used, embodiments and components “consisting essentially of” and “consisting of” are expressly disclosed and described herein.”
Furthermore, the Abstract is not intended to be limiting as to the scope of the claimed invention and is for the purpose of quickly determining the nature of the claimed invention.
The present application claims priority to and is a nonprovisional of a provisional U.S. patent application No. 62/463,126 tilted “Device and Method to Measure Gas Concentrations using Electromagnetic Techniques” and filed on Feb. 24, 2017 by Applicant Nokomis, Inc. The present application also relates to co-pending US patent application number (Docket No. NOK 17007), titled “Device and Method to Detect, Analyze or Measure Tissue Characteristics and Anomalies using Electromagnetic Techniques” and filed concurrently herewith by Applicant Nokomis, Inc. The foregoing references are hereby incorporated herein by reference in their entirety.
| Number | Date | Country | |
|---|---|---|---|
| 62463126 | Feb 2017 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 15459494 | Mar 2017 | US |
| Child | 16578876 | US |
