Apparatus and methods for facilitating treatment of tissue via improved delivery of energy based and non-energy based modalities

Abstract
Methods and apparatus for accessing and treating regions of the body are disclosed herein. Using an endoscopic device having an automatically controllable proximal portion and a selectively steerable distal portion, the device generally may be advanced into the body through an opening. The distal portion is selectively steered to assume a selected curve along a desired path within the body which avoids contact with tissue while the proximal portion is automatically controlled to assume the selected curve of the distal portion. The endoscopic device can then be used for accessing various regions of the body which are typically difficult to access and treat through conventional surgical techniques because the device is unconstrained by “straight-line” requirements. Various applications can include accessing regions of the brain, thoracic cavity, including regions within the heart, peritoneal cavity, etc., which are difficult to reach using conventional surgical procedures.
Description
FIELD OF THE INVENTION

The present invention relates generally to endoscopes and endoscopic medical procedures. More particularly, it relates to methods and apparatus for accessing and treating regions within the body which are difficult to reach through conventional surgical devices and procedures.


BACKGROUND OF THE INVENTION

Many surgical procedures typically require large incisions be made to provide access to regions within the body. For instance, operating on or near the posterior regions of the heart is ordinarily performed using open-chest techniques. Such a procedure generally requires a gross thoracotomy or sternotomy, which are both highly invasive and attendant with a great deal of risks, such as ischemic damage to the heart, formation of emboli, etc. A thoracotomy typically involves creating an incision in the intercostal space between adjacent ribs while a sternotomy involves the “chest spreader” approach, which is generally the most invasive. Moreover, such an invasive procedure produces significant morbidity, increased mortality rates, and significantly increases recovery time for the patient.


Minimally invasive surgery is an alternative surgical procedure in which small incisions are made in the patient's body to provide access for various surgical devices for viewing and operating inside the patient. Laparoscopes are typically used for accessing and performing operations within the body through these small incisions using specially designed surgical instruments. These instruments generally have handles which are manipulatable from outside of the patient's body by the surgeon to control the operation of the instrument typically through an elongated tubular section which fits through a tube, introducer, or trocar device entering the patient's body.


However, even conventional laparoscopic procedures are limited in applicability in part because of a “straight-line” requirement in utilizing laparoscopic tools. This requirement makes accessing certain areas within the body extremely difficult, if not impracticable. Moreover, the lack of flexibility of these tools have made access to certain regions of the body difficult, forcing many surgeons to resort to open surgery rather than utilizing conventional minimally invasive procedures.


Flexible endoscopic devices are also available for use in minimally invasive surgical procedures in providing access to regions within the body. Flexible endoscopes are typically used for a variety of different diagnostic and interventional procedures, including colonoscopy, bronchoscopy, thoracoscopy, laparoscopy and video endoscopy. A flexible endoscope may typically include a fiberoptic imaging bundle or a miniature camera located at the instrument's tip, illumination fibers, one or two instrument channels that may also be used for insufflation or irrigation, air and water channels, and vacuum channels. However, considerable manipulation of the endoscope is often necessary to advance the device through the body, making use of conventional devices more difficult and time consuming and adding to the potential for complications.


Steerable flexible endoscopes have been devised to facilitate selection of the correct path through regions of the body. However, as the device is typically inserted farther into the body, it generally becomes more difficult to advance. Moreover, friction and slack in the endoscope typically builds up at each turn, making it more difficult to advance and withdraw the device. Another problem which may arise, for example, in colonoscopic procedures, is the formation of loops in the long and narrow tube of the colonoscope. Such loops may arise when the scope encounters an obstacle, gets stuck in a narrow passage, or takes on a shape that incorporates compound curves. Rather progressing, the scope forms loops within the patient. In an attempt to proceed in insertion of the colonoscope, for example, excess force may be exerted, damaging delicate tissue in the patient's body. The physician may proceed with the attempted insertion of the endoscope without realizing there is a problem.


Through a visual imaging device the user can observe images transmitted from the distal end of the endoscope. From these images and from knowledge of the path the endoscope has followed, the user can ordinarily determine the position of the endoscope. However, it is difficult to determine the endoscope position within a patient's body with any great degree of accuracy.


None of the instruments described above is flexible enough to address the wide range of requirements for surgical procedures performed internally to the patient's body. Furthermore, the instruments described lack the ability to rotate the distal tip about the longitudinal axis of the instrument while fully articulating the tip to any setting relative to the tubular section of the instrument. This lack of flexibility requires surgeons to manually rotate and move the instrument relative to the patient body to perform the procedure.


BRIEF SUMMARY OF THE INVENTION

Endoscopic devices, as described below, may be particularly useful in treating various regions within the body. Such endoscopes may include a steerable distal portion and an automatically controlled proximal portion which may be controlled by a physician or surgeon to facilitate steering the device while the proximal portion may be automatically controlled by, e.g., a controller or computer. The steerable endoscope may be advanced within the body of a patient, e.g., via any one of the natural orifices into the body such as through the anus. Alternatively, the device may be introduced percutaneously through a small incision into the body. Once the endoscopic device has been introduced into the body, it may be advanced and maneuvered to avoid obstructing anatomical features such as organs, bones, etc., without impinging upon the anatomy of the patient. Examples of such devices are described in detail in the following patents and co-pending applications: U.S. Pat. Nos. 6,468,203; 6,610,007; U.S. patent application Ser. No. 10/087,100 filed Mar. 1, 2002; U.S. patent application Ser. No. 10/139,289 filed May 2, 2002, U.S. patent application Ser. No. 10/229,577 filed Aug. 27, 2002; U.S. patent application Ser. No. 10/229,814 filed Aug. 27, 2002, and U.S. patent application Ser. No. 10/306,580 filed Nov. 27, 2002, each of which is incorporated herein by reference in its entirety.


Using such a device, one method of treating an obstructed region of tissue within a body, may generally comprise advancing an elongate device into the body through an opening, the elongate device having a proximal portion and a selectively steerable distal portion and the elongate device having a plurality of segments, selectively steering the distal portion to assume a selected curve along a desired path within the body which avoids contact with tissue (or does not require displacement of adjacent tissue along the desired path or avoids applying excess force to the adjacent tissue), and further advancing the elongate device through the body and towards the region of tissue to be treated while controlling the proximal portion of the device to assume the selected curve of the distal portion.


Using any one of the controllable endoscopic devices, various regions of the body which are typically difficult to access and treat through conventional surgical techniques, may be accessed and treated accordingly. In one treatment variation, the endoscopic device may be utilized for neurological surgical applications. Because the endoscopic device is unconstrained by “straight-line” requirements for accessing regions of the brain which are conventionally difficult to reach and/or because the device avoids forming loops when advanced, the endoscope may be accurately advanced and positioned within the cranium by steering the device around the brain with minimal or no trauma to healthy brain tissue. The endoscope may also be advanced through the tissue as necessary to access treatment areas embedded deep within the tissue through pathways which may minimize any damage to healthy adjacent tissue. Furthermore, because the endoscopic device may allow access to sensitive regions over or within the brain, minimally invasive surgery may be performed where conventional surgery would normally require removal of portions of the skull, for instance, in craniotomy procedures or treatment of intracranial hematomas, etc. In addition, access through the nasal passages or other natural cranial orifices may be facilitated.


Another area of treatment in which the endoscopic device may be utilized may include use for coronary procedures, e.g., treatment of the mitral valve, tissue ablation for the treatment of atrial fibrillation, placement, removal, or adjustment of pacing leads, etc. In one example, the endoscopic device may be introduced within the heart via the superior vena cava and advanced through the right atrium. Once the endoscope is within the right atrium, the distal portion may be steered through the atrial septum and into the left atrium where the distal portion of the device may be positioned adjacent to the tissue to be treated, in this example, the mural valve. To affect treatment, various tools or devices, e.g., scalpels, graspers, etc., may be delivered through one or several working channels within the device to effect the treatment.


In yet another area of treatment in which the endoscopic device may be utilized, various thoracoscopy procedures may be accomplished in a minimally invasive procedure, e.g., percutaneously. As shown, the endoscope may be advanced into the patient via an introducer or port, which may also be configured as a datum for establishing a fixed point of reference for the endoscope during the procedure. The port or datum may be in electrical communication with a computer or processor used for determining and/or maintaining the position of the device within the patient. The endoscope may be advanced into the body of the patient through an incision made, e.g., in the intercostal space between the ribs. The endoscope may then be advanced into the thoracic cavity and maneuvered to regions within the body such as the posterior region of the heart which are normally inaccessible for conventional laparoscopic procedures due to a lack of straight-line access.


One embodiment of the present invention provides a method for facilitating a treatment within a body including inserting an endoscope having a steerable distal end and a controllable proximate end, the controllable proximate end being controlled to follow the steerable distal end. The endoscope is maneuvered into a position within the body to facilitate a treatment of a body portion. A treatment is performed on the body portion. The body portion could be, for example, in the thoracic cavity, the skull, or the peritoneal cavity.


Another embodiment of the present invention provides a system for performing a treatment of a condition related to a physiological indication within a body. There is a system for detecting and localizing a physiological indication within the body. A system for providing imaging of a portion of the body related to the physiological indication within the body. A steerable endoscope having a steerable distal end and a controllable proximate end under the control of a computer controller that receives information from the system for detecting and the system for providing.


Another embodiment of the present invention provides a system for facilitating a treatment of the heart having a system for indicating the location of an errant condition of the heart. There is also provided a controller system utilizing information generated by the system for indicating to assist in the articulation of a steerable endoscope having a steerable distal end and a controllable proximate end to follow the steerable distal end into a position to facilitate a treatment of the errant condition of the heart. In addition, there is provided a treatment device provided by the steerable endoscope to perform a treatment of the errant condition of the heart.


In another embodiment of the present invention, there is provided an apparatus for performing a cardiac ablation therapy having a steerable endoscope having a steerable distal end and a controllable proximate end configured to automatically follow the configuration of the steerable distal end. An ablation therapy device adapted to be deployed by the steerable endoscope. A fastener that fixes the position of the ablation therapy device.


Another embodiment of the present invention provides a method of performing a treatment within the body by advancing a steerable distal end of an endoscope along a pathway into a treatment position to facilitate a treatment within a body. The proximate end of the endoscope is controlled to follow the pathway of the steerable distal end of the endoscope. A treatment element is provided to the treatment position.


embodiment of the present invention utilizes a pair of steerable endoscopes to deliver a therapy within the body. The pair of endoscopes may be arranged such that one endoscope is within the other endoscope or, alternatively, where one endoscope is adjacent the other endoscope. In another embodiment, one steerable endoscope may be maneuvered into a desired position within the body to facilitate treatment and then fixed into that position. Thereafter, the second endoscope may be maneuvered to perform the therapy or facilitate a treatment utilizing the fixed position within the body provided by the first endoscope. This procedure may be useful in conditions of movement, such as beating heart treatments where the first endoscope may be used as a fixed treatment point for utilizing the second endoscope.


The endoscope device may also be utilized for procedures within the peritoneal cavity. Potential applications may include minimally invasive surgery for urologic, bariatric, and liver surgery. Moreover, minimally invasive access may be achieved for treatments in spinal or orthopedic surgery as well. In such a procedure, the endoscope may be introduced into the patient through an incision via a port, which may also function as a datum. The distal portion may be steered to avoid various organs while being advanced to a tissue region to be treated, e.g., the liver. The distal portion of the endoscope may accordingly be steered while the proximal portion may be automatically controlled to follow a path defined by the distal portion which minimizes contact with the surrounding and adjacent tissue and organs. In this or any other procedure, one or more laparoscopes may optionally be used in combination with the endoscope to assist with the surgical procedure.





BRIEF DESCRIPTION OF THE DRAWINGS


FIG. 1 shows one variation of a steerable endoscope which may be utilized for accessing various regions within the body without impinging upon the anatomy of the patient.



FIG. 2A shows a wire frame model of a section of the elongate body of the endoscope in a neutral or straight position.



FIG. 2B shows an illustration of the endoscope body maneuvered through a curve with the selectively steerable distal portion and automatically controlled proximal portion.



FIG. 3 shows a cross-sectional side view of a patient's head with a variation of the endoscope being advanced therethrough.



FIG. 4 shows the interaction of several components to provide a method of positioning a steerable endoscope system to facilitate treatment.



FIG. 5 shows a cross-sectional anterior view of a heart with the endoscopic device introduced via the superior vena cava and advanced to the right atrium.



FIG. 6 shows an example of a thoracoscopy procedure which may be performed percutaneously with the endoscopic device.



FIGS. 7A, 7B, 7C, and 7D progressively show an example of the endoscopic device being advanced about the posterior region of a heart to facilitate treatment of a supraventricular tachycardia.



FIGS. 8A, 8B, 8C, and 8D progressively show an example of the endoscopic device being advanced about the posterior region of a heart and retracted to deploy a device to facilitate treatment of a supraventricular tachycardia.



FIG. 9 shows an embodiment of a treatment device having a plurality of fasteners to facilitate contact between the treatment device and the surrounding tissue.



FIGS. 10A and 10B show additional examples of the endoscopic device advanced about the posterior region of a heart to facilitate treatment of a supraventricular tachycardia (FIG. 10A) and a combination of supraventricular and ventricular tachycardia (FIG. 10B).



FIG. 11 shows yet another example of a treatment for atrial fibrillation using the endoscopic device.



FIGS. 12A, 12B, 12C, and 12D show additional examples of the endoscopic device advanced about the posterior region of a heart to facilitate treatment of a supraventricular tachycardia and/or combinations of supraventricular and ventricular tachycardia.



FIG. 13 shows an embodiment of a dual, steerable endoscope of the present invention utilized to facilitate treatment of the heart.



FIGS. 14A, 14B, and 14C show side and end views, respectively, of various electrode configurations on the endoscope for tissue ablation treatment.



FIGS. 15A and 15B show an embodiment of a needle array in a retracted (FIG. 15A) and a deployed (FIG. 15B) configuration.



FIG. 16 shows an embodiment of a needle array having a continuous spacing.



FIG. 17 shows an embodiment or a needle array having a variety of spacing configurations.



FIGS. 18A and 18B show a side and isometric view of an embodiment of a treatment device of the present invention.



FIGS. 18C and 18D show a plurality of the treatment devices in optimized positions for facilitating a therapy.



FIG. 19 shows a graph illustrating a technique to optimize placement of a device to facilitate therapy.



FIG. 20 shows an example of a procedure within the peritoneal cavity which may be performed with the endoscopic device.





DETAILED DESCRIPTION OF THE INVENTION

In treating various regions within the body, a number of different endoscopic devices may be utilized in facilitating access. Endoscopic devices which are particularly useful may include various endoscopes having a steerable distal portion and an automatically controlled proximal portion. Generally, the steerable distal portion may be controlled by a physician or surgeon to facilitate steering the device while the proximal portion may be automatically controlled by, e.g., a controller or computer. The steerable endoscope may be advanced within the body of the patient through a number of different methods. For instance, the endoscope may be introduced via anyone of the natural orifices into the body such as through the anus. Alternatively, the device may be introduced percutaneously through a small incision into the body. Once the endoscopic device has been introduced into the body, it may be advanced and maneuvered, as described below, to avoid obstructing anatomical features such as organs, bones, etc., without impinging upon the anatomy of the patient.



FIG. 1 illustrates one variation of a steerable endoscope 100 which may be utilized for accessing various regions within the body without impinging upon the anatomy of the patient. The endoscope 100 generally has an elongate body 102 with a manually or selectively steerable distal portion 104 and an automatically controlled proximal portion 106. The selectively steerable distal portion 104 may be selectively steered or bent up to a full 180° bend in any direction, as shown by the dashed lines. A fiberoptic Imaging bundle 112 and one or more illumination fibers 114 may optionally be extended through the body 102 from the proximal end 110 to the distal end 108. Alternatively, the endoscope 100 may be configured as a video endoscope with a miniaturized video camera, such as a CCD or CMOS camera, positioned at the distal end 108 of the endoscope body 102. The images from the video camera may be transmitted to a video monitor by a transmission cable or by wireless transmission. Optionally, the body 102 of the endoscope 100 may also include at least one or two instrument channels 116, 118 that may be used to provide access through the endoscope for any number of tools. Channels 116, 118 may also be used for various other purposes, e.g., insufflation or irrigation.


The elongate body 102 of the endoscope 100 is highly flexible so that it is able to bend around small diameter curves without buckling or kinking. The elongate body 102 of the endoscope 100 may range in length typically from, e.g., 135 to 185 cm, and 12 to 13 mm in diameter. However, if the endoscope 100 were utilized in regions within the body which are smaller than the space within, e.g., the gastrointestinal tract, the device may be modified in size to be small in diameter. The endoscope 100 may also be modified in length to be longer or shorter, depending upon the desired application.


A handle 120 is attachable to the proximal end 110 of the elongate body 102. The handle 120 may include an ocular 124 connected to the fiberoptic imaging bundle 112 for direct viewing and/or for connection to a video camera 126. The handle 120 may also be connected to an illumination source 128 via an illumination cable 134 that may be connected to or continuous with the illumination fibers 114. An optional first luer lock fitting 130 and an optional second luer lock fitting 132, which may be in communication with instrument channels 116, 118, respectively, may also be located on or near the handle 120.


The handle 120 may be connected to an electronic motion controller 140 by way of a controller cable 136. A steering control 122 may be connected to the electronic motion controller 140 by way of a second cable 138. The steering control 122 may configured to allow the physician or surgeon to selectively steer or bend the selectively steerable distal portion 104 of the elongate body 102 in the desired direction. The steering control 122 may be a joystick controller as shown, or other known steering control mechanism. Alternatively, the steering may be effected manually, e.g. by the use of cables, hydraulics, or pneumatics, or any other known mechanical apparatus for controlling the distal portion of the elongate body. The electronic motion controller 140 may be used to control the motion of the automatically controlled proximal portion 106 of the elongate body 102 and may be implemented using a motion control program running on a microcomputer or through an application-specific motion controller. Alternatively, the electronic motion controller 140 may be implemented using a neural network controller.


An axial motion transducer 150 may be provided to measure the axial motion of the elongate body 102 as it is advanced and withdrawn. The axial motion transducer 150 can be made in many configurations, some of which are described below. In this variation, the axial motion transducer 150 is configured as a ring 152, for illustrative purposes only, that surrounds the elongate body 102 of the endoscope 100. The axial motion transducer 150 may be attached to a fixed point of reference, such as the surgical table or the insertion point for the endoscope 100 on the patience's body, as described below. As the body 102 of the endoscope 100 slides through the axial motion transducer 150, it produces a signal indicative of the axial position of the endoscope body 102 with respect to the fixed point of reference and sends a signal to the electronic motion controller 140 by telemetry or by a cable (not shown). The axial motion transducer 150 may use optical, electronic, magnetic, mechanical, etc., methods to determine the axial position of the endoscope body 102. In addition, the motion transducer may be configured to simultaneously measure and communicate rotational motion of the endoscope, so that this additional data may be used in the control of the instrument's motion. A further detailed description of the axial motion transducer 150 and variations thereof may be found in U.S. patent application Ser. No. 10/384,252 filed Mar. 7, 2003, which is incorporated herein by reference in its entirety.


To illustrate the basic motion of the steerable endo scope 100, FIG. 2A shows a wire frame model of a section of the body 102 of the endoscope 100 in a neutral or straight position. Most of the internal structure of the endoscope body 102 has been eliminated in this drawing for the sake of clarity. The endoscope body 102 is divided up into sections 1, 2, 3 . . . 10, etc. The geometry of each section is defined by four length measurements along the a, b, c and d axes. For example, the geometry of section 1 may be defined by the four length measurements 11a, 11b, 11c, 11d, and the geometry of section 2 may be defined by the four length measurements 12a, 12b, 12c, 12d, etc. The geometry of each section may be altered using the linear actuators to change the four length measurements along the a, b, c and d axes. For example, to bend the endoscope body 102 in the direction of the a axis, the measurements 11a, 12a, 13a . . . 110a can be shortened and the measurements 11b, 12b, 13b . . . 110b can be lengthened an equal amount. The amount by which these measurements are changed determines the radius of the resultant curve. In automatically controlled proximal portion 106, however, the a, b, c and d axis measurements of each section may be automatically controlled by the electronic motion controller 140.


In FIG. 2B, the endoscope body 102 has been maneuvered through the curve C with the benefit of the selectively steerable distal portion 104 and now the automatically controlled proximal portion 106 resides in the curve C. Sections 1 and 2 are in a relatively straight part of the curve C, therefore 11a=11b and 12a=12b. However, because sections 3-7 are in the S-shaped curved section, 13a<13b, 14a<14b and 15a<15b, but 16a>16b, 17a>17b and 18a>18b. When the endoscope body 102 is advanced distally by one unit, section 1 moves into the position marked 1′, section 2 moves into the position previously occupied by section 1, section 3 moves into the position previously occupied by section 2; etc. The axial motion transducer 150 produces a signal indicative of the axial position of the endo scope body 102 with respect to a fixed point of reference and sends the signal to the electronic motion controller 140. Under control of the electronic motion controller 140, each time the endoscope body 102 advances one unit, each section in the automatically controlled proximal portion 106 is signaled to assume the shape of the section that previously occupied the space that it is now in. Therefore, when the endoscope body 102 is advanced to the position marked 1′, 11a=11b, 12a=12b, 13a=13b, 14a<14b, 15a<15b, 16a<16b, 17a>17b, 18a>18b, and 19a>19b, and, when the endoscope body 102 is advanced to the position marked 1″, 11a=11b, 12a=12b, 13a=13b, 14a=14b, 15a<15b, 16a<16b, 17a<17b, 18a>18b, 19a>19b, and 110a>110b. Thus, the S-shaped curve propagates proximally along the length of the automatically controlled proximal portion 106 of the endoscope body 102. The S-shaped curve appears to be fixed in space, as the endoscope body 102 advances distally.


Similarly, when the endoscope body 102 is withdrawn proximally, each time the endoscope body 102 is moved proximally by one unit, each section in the automatically controlled proximal portion 106 is signaled to assume the shape of the section that previously occupied the space that it is now in. The S-shaped curve propagates distally along the length of the automatically controlled proximal portion 106 of the endoscope body 102, and the S-shaped curve appears to be fixed in space, as the endoscope body 102 withdraws proximally.


Whenever the endoscope body 102 is advanced or withdrawn, the axial motion transducer 150 may be used to detect the change in position and the electronic motion controller 140 may be used to propagate the selected curves proximally or distally along the automatically controlled proximal portion 106 of the endoscope body 102 to maintain the curves in a spatially fixed position. Similarly, if the endoscope 102 is rotated, a rotational motion transducer (separate from or integrated within transducer 150) may be used to detect the change in position and the electronic motion controller may be similarly used to adjust the shape of the endoscope body 102 to maintain the curves in a spatially fixed position. This allows the endoscope body 102 to move through tortuous curves without putting unnecessary force on the wall of the curve C.


Examples of other endoscopic devices which may be utilized in the present invention are described in further detail in the following patents and co-pending applications, U.S. Pat. Nos. 6,468,203; 6,610,007; U.S. patent application Ser. No. 10/087,100 filed Mar. 1, 2002; U.S. patent application Ser. No. 10/139,289 filed May 2, 2002, U.S. patent application Ser. No. 10/229,577 filed Aug. 27, 2002; U.S. patent application Ser. No. 10/229,814 filed Aug. 27, 2002, and U.S. patent application Ser. No. 10/306,580 filed Nov. 27, 2002, each of which has been incorporated herein by reference above.


Therefore, using anyone of the controllable endoscopic devices described above, various regions of the body which are typically difficult to access and treat through conventional surgical techniques, may be accessed and treated accordingly. In one treatment variation, the endoscopic device may be utilized for neurological surgical applications. Because the endoscopic device is unconstrained by “straight-line” requirements for accessing regions of the brain which are conventionally difficult to reach, the endoscope may be advanced and positioned within the cranium by steering the device around the brain with minimal or no trauma to healthy brain tissue. The endoscope may also be advanced through the tissue as necessary to access treatment areas embedded deep within the tissue through pathways which may minimize any damage to healthy adjacent tissue. Furthermore, because the endoscopic device may allow access to sensitive regions over or within the brain, minimally invasive surgery may be performed where conventional surgery would normally require removal of portions of the skull, for instance, in craniotomy procedures or treatment of intracranial hematomas, etc.



FIG. 3 shows a cross-sectional side view of head 202 of patient 200. The brain 206 may be seen within the cranial cavity 210 of cranium 204. The endoscopic device 212 is an embodiment of a steerable endoscope of the present invention that has been sized, shaped and configured for accessing the interior of the cranial cavity and external and internal regions of the brain. The movement, position, tracking and control of the endoscopic device 212 is performed by a user alone or in cooperation with any or all of imaging systems, position and location systems, and surgical planning methods and techniques. In treating regions of the brain 206 which may be difficult to normally access, the endoscopic device 212 may be introduced into the cranial cavity 210 from an easily accessible insertion site 222, e.g., a perforation within the skull. The endoscope 212 may be then advanced through the insertion site 222 by controlling the steerable distal portion 214 to avoid brain tissue. As the endoscope 212 is further advanced into the cranial cavity 210, the automatically controlled proximal portion 216 may attain the shape defined by the steerable distal portion 214 to avoid contact with brain tissue 206.


The endoscope 212 may be further advanced through the cranial cavity 210 and within the cerebrospinal fluid so that the device is advanced above or within the layers of the meninges, e.g., within the subarachnoid space. In either case, the endoscope 212 may be steered along a path which avoids or minimizes contact or pressure against the brain tissue 206. As the proximal portion 216 is advanced distally and attains the shape defined by the distal portion 214, the proximal portion 216 likewise may be controlled to automatically avoid or minimize contact or pressure against the brain tissue 206. Once the distal portion 216 is advanced to the desired treatment region 208, various tools 220 may be introduced through the instrument channel 218 to enable treatment of the region 208. Any number of treatments or procedures may accordingly be effected, e.g., tumor biopsy and/or removal, shunt placement, lead placement, device placement, drainage of excess cerebrospinal fluid or blood, etc.



FIG. 4 shows the interaction of several components to provide a method of positioning a steerable endoscope system to facilitate treatment. As mentioned above, the movement, position, tracking and control of endoscopic devices according to the present invention is performed by a user alone or in cooperation with any or all of imaging systems, position and location systems, and surgical planning methods and techniques. The system schematic 4000 illustrates one embodiment of an integrated detection, mapping and control system for positioning and controlling a steerable, controllable endoscope of the present invention. First, a suitable device, element or system is used to detect and localize a physiological indication (4010). A physiological indication could be any perceptible indicia of a condition for which treatment may be facilitated. In a coronary example, physiological indicators include electrophysiology data or electrical signals from the heart. This system would be capable of identifying or performing analysis of monitored data to identify or determine the location of errant activity.


Next, information regarding the detected and localized physiological indication is passed to an image/mapping system (4020). An image/mapping system includes any imaging modality that may provide position, location, tissue type, disease state, or any other information that facilitates correlating the physiological activity to an identifiable and/or localizable position within the anatomy or within a frame of reference. Examples of image/mapping systems include any of the imaging technologies such as x-ray, fluoroscopy, computed tomography (CT), three dimensional CAT scan, magnetic resonance imaging (MRI), and magnetic field locating systems. Examples of image/mapping systems specifically suited for the treatment of cardiovascular disorders include electrocardiogram detection systems, cardiac electrophysiology mapping systems, endocardial mapping systems, or other systems and methods that provide the ability acquire, visualize, interpret and act on cardiac electrophysiological data. An example of such a system is described in U.S. Pat. No. 5,848,972 entitled, “Method for Endocardial Activation Mapping Using a Multi-Electrode Catheter” the entirety of which is incorporated herein by reference. Additional examples are described in U.S. Pat. Nos. 5,487,385; 5,848,972; and 5,645,064, the entirety of each of these patents is incorporated by reference. Integrated mapping, detection and/or ablation probes and devices may also be delivered using the steerable endoscope of the present invention. One such integrated system is described in US Patent Application Publication US 2003/0236455 to Swanson et al the entirety of which is incorporated herein by reference. Additional other systems may provide mapping, display or position information of a local isochronal activation map of the heart along with the relative position of the endoscope and direction information or movement commands to position the endoscope (or components, elements or systems onboard the endoscope) to provide treatment to the source of the arrhythmia.


Next, information provided, compiled and/or analyzed in the prior steps or other additional information provided by a user or other system used by the user is input into or utilized by the endoscope controller (4030). This step indicates the ability of the endoscope controller to respond to the indication, position, image, mapping and other data and utilize that data for altering the scope configuration, position, orientation or other relational information indicative of the scope controller responding to the information provided. The endoscope is configured to provide of facilitate providing components, elements or systems to facilitate a treatment of the physiological indication being monitored. The controller utilizes the data provided to position the steerable, controllable endoscope into a position related to the location or site that exhibits the errant activity. The proximity of the endoscope to the location or site of the errant activity will vary depending upon, for example, the treatment being implemented, the element, component or system being used to facilitate treatment.


Finally, the position of the endoscope is supplied back into the image or mapping system as a form of feedback to better assist in guiding the endoscope into the desired position to facilitate treatment (4040).


In another embodiment, the system 4000 may include an overall mapping system that provides medically significant data that facilitates a treatment. This overall mapping or imaging system may include mapping or imaging an area of monitored activity. The area of monitored activity includes not only the portion of the body important to the treatment but also imaging information of those other parts of the body not impacted by the treatment but are instead the likely pathway(s) of the steerable, controllable endoscope to reach the area where the treatment will be facilitated. In addition, some embodiments of the system may include the ability to detect, localize or otherwise indicate the position of the treatment area or area of errant activity or conditions subject to treatment. These indications may then be utilized to augment the guidance of the steerable, controllable endoscope into the desired position to facilitate treatment. In addition, other medical imaging and tracking systems may be utilized to provide tracking, guidance and position feedback information to the control of the steerable endoscope. An exemplary system is described by Dumoulin et al. in U.S. Pat. No. 5,377,678 which is incorporated herein by reference in its entirety.


The above steps are only representative of one embodiment of how physiological indications, and position information may be utilized to improve the guidance system and controls used by steerable endoscopes to ensure the placement of the endoscope to facilitate treatment. It is to be appreciated that the steps were utilized for clarity and ease of discussion. The methods of embodiments of the invention are not so limited. For example, a single system could be used as an integrated indication, imaging, endoscope controller that receives endoscope position feedback in real time. In an alternative example, the physiological indication and image/mapping functions may be combined into a single unit. As such, while the above steps have been described as happening only once or in a serial fashion, it is to be appreciated that the steps may be conducted in as different order or multiple times. Other physiological indication detection and localization systems may be used and will correspond to an appropriate system useful in the treatment being performed. In addition, alternative image and mapping systems may also be employed and may also be selected depending upon the treatment being facilitated through the use of a steerable controllable endoscope of the present invention. The system may also control the movement of the endoscope automatically based on inputs from the user, pre-surgical planning data, or other indications of desired pathways or pathways to avoid. Alternatively, or in addition, a user may input additional guidance or control information into the system for furthering the guidance or desired placement of the endoscope.


Another area of treatment in which the endoscopic device may be utilized may include use for coronary procedures, e.g., treatment of the mitral valve, performing or facilitating treatment of supraventricular tachycardia, including, for example, tissue ablation for the treatment of atrial fibrillation, treatment of ventricular tachycardia alone or in combination with treatment of supraventricular tachycardia, treatments for the placement, repositioning or removal of device leads, etc. Atrial fibrillation is typically sustained by the presence of multiple electrical reentrant wavelets propagating simultaneously in the atria of the heart. Surgical and catheter-based techniques typically place segmented or continuous lesions near and around the pulmonary veins as one way to re-synchronize the atria.


In addition, a variety of ablation techniques using energy based and non-energy based modalities may be utilized to ablate soft tissue. Embodiments of the present invention may be utilized to facilitate ablation therapies, ablation elements and devices that employ one or a combination of energy modalities, such as, for example, cryogenic energy, hydraulic energy, laser energy, magnetic energy, mechanical energy, microwave energy, radiation energy, radio-frequency energy, thermal energy, and ultrasonic energy. Microwave ablation systems may include, for example, those based on AFx microwave surgical ablation systems such as the AFx Flex 4 or the like. AFx is currently owned by Guidant Corp. Cryogenic ablation systems may include, for example, systems available from Cryocath Technologies such as the “SurgiFrost,” “Frostbyte” or “Artic Circler” systems and the like. Ultrasound based surgical probes may be, for example, based upon the ultrasound ablation systems produced by EpiCor Medical or the like. A large number of commercially available ablation systems are available to illustrate the wide variety of ablation systems, techniques and modalities that may be delivered or utilized by embodiments of the steerable endoscopic systems of the present invention.


As shown in FIG. 5, a cross-sectional anterior view of heart 302 may be seen in coronary procedure 300 for treatment of the mitral valve MV located between the left atrium LA and the left ventricle LV. The endoscopic device 212 is shown in this treatment variation as being introduced within the heart 302 via the superior vena cava SVC and advanced through the right atrium RA. Also shown is the right ventricle RV below the tricuspid valve TV and inferior vena cava IVC. The endoscope 212 may be sized accordingly to be delivered intravascularly. Once the endoscopic device 212 is within the right atrium RA, the distal portion 214 may be steered towards the atrial septum AS which separates the left atrium LA and right atrium RA. Once at the atrial septum AS, a cutting tool deliverable through the device 212 may be used to perforate the atrial septum AS to allow passage of the endoscopic device 212 into the left atrium LA. The distal portion 214 may then be steered and positioned adjacent the mitral valve MV while the proximal portion 216 is automatically controlled to minimize any pressure which may be exerted by the device 212 against the tissue of the heart 302. Once the endoscopic device is adjacent to the tissue to be treated, in this example the mitral valve MV, various tools or devices may be delivered through the channel 218 to effect the treatment. Once the procedure has been completed, the endoscope 212 may simply be withdrawn proximally in the same manner while minimizing any contact pressure against the tissue.


In yet another area of treatment in which the endoscopic device may be utilized, various thoracoscopy procedures may be accomplished in a minimally invasive procedure. FIG. 6 shows an example of a thoracoscopy procedure 400 which may be performed percutaneously. As shown, the endoscope 212 may be advanced into the patient 402 via an introducer or port 412, which may also be configured as a datum for establishing a fixed point of reference for the endoscope 212 during the procedure. The port or datum 412 may be in electrical communication via electrical lines 418 with a computer or processor 416 which may be used for determining and/or maintaining the position of the device 212 within the patient 402. The endoscope 212 may be advanced into the body of the patient 402 through an incision 414 made, e.g., in the intercostal space between the ribs 404. The endoscope 212 may then be advanced into the thoracic cavity and maneuvered to regions within the body such as the posterior region of the heart 408 which are normally inaccessible for conventional laparoscopic procedures due to a lack of straight-line access.


In this example, the endoscopic device 212 is shown having been inserted through port or datum 412 and advanced posteriorly of heart 408 behind sternum 406. The lungs are not shown for the sake of clarity; however, the endoscope 212 may be steered and advanced around the lungs in a manner described above so as to avoid contact or to minimize contact with the lung tissue or any other organs or structures which may be obstructing a straight-line path.


The endoscopic device 212 is capable of reaching regions within the body, without damaging surrounding tissue, which is normally inaccessible via conventional laparoscopic procedures. FIGS. 7A to 7D show an example of the endoscopic device advanced about the posterior region of a heart to facilitate treatment of a supraventricular tachycardia. One example of a supraventricular tachycardia is atrial fibrillation. Another procedure 500 is shown in FIGS. 7A to 7D, which illustrate how the endoscopic device may be utilized for the treatment of atrial fibrillation. The figures show a posterior view of the heart with the aorta AA and pulmonary trunk PT as anatomical landmarks. Atrial fibrillation is typically sustained by the presence of multiple electrical reentrant wavelets propagating simultaneously in the atria of the heart. Surgical and catheter-based techniques typically place segmented or continuous lesions near and around the pulmonary veins as one way to re-synchronize the atria.


The endoscopic device 212 may be utilized by advancing the device 212 into the thoracic cavity, as described above or through various other channels, and steered towards the posterior region of the heart. In the example shown in FIGS. 7A to 7D, the steerable distal portion 214 may be advanced as shown in FIG. 7A such that the endoscope 212 approaches above the left pulmonary veins LPV. As shown in FIG. 7B, the distal portion 214 may be steered around the right pulmonary veins RPV while the endoscope 212 is advanced distally. The automatically controllable proximal portion 216 may thus assume the shape defined by the distal portion 214 in traversing around the pulmonary vessels. As shown in FIG. 7C, the distal portion 214 is steered around the left pulmonary vessels LPV while the proximal portion has assumed the curved path traversed by the device around the right pulmonary vessels RPV. Finally in FIG. 7D, the device 212 may be fully advanced entirely around the pulmonary vessels such that the distal portion 214 and proximal portion 216 are in intimate contact against the heart tissue while maintaining its configuration. The tissue which is in contact against the device 212 may then be ablated by one or several electrodes located along the length of the distal and/or proximal portions 214, 216, as described in further detail below. Alternately, an ablation device such as a catheter or other energy source, may be delivered through one or more working channels in or on the endoscope, and left in place as desired. This ablation device may then be used to deliver ablative energy in various forms, e.g., RF, microwave, cryogenic cooling, etc., as described herein or known to those of ordinary skill in the art. The device may be held fixedly in the desired location by various methods, e.g., vacuum, magnetically, temporary adhesives, sutures, or any other methods of attaching or approximating the device and tissue.



FIGS. 8A to 8D show an example of a procedure 600 wherein a steerable endoscopic device is advanced about the posterior region of a heart and then retracted to deploy a device to facilitate treatment of a supraventricular tachycardia. The steerable endoscopic device 800 is capable of reaching regions within the body as described above and as an improvement over laparoscopic procedures. The figures show a posterior view of the heart with the aorta AA and pulmonary trunk PT as anatomical landmarks. FIG. 8A illustrates an endoscopic device 800 having a steerable, controllable distal end 805 and a controllable proximal end 810. In FIG. 8A, at the beginning of the procedure 600 the endoscopic device 800 has been maneuvered into position to initiate deployment of an ablation device 815. It is to be appreciated that in this exemplary procedure 600 the steerable endoscopic device 800 has been maneuvered to the initial deployment point by tracing out a desired deployment or treatment pathway about the pulmonary veins. While illustrated with regard to the pulmonary veins for purposes of the discussion of procedure 600, the utilization of the steerable endoscope is not so limited and may be used to trace out desired treatment pathways about organs, tissues and body portions as desired. FIG. 8A also illustrates the ablation device 815 distal end is attached to the heart using any of the attachment methods described in this application or known to those of ordinary skill in the art.


Next, in FIGS. 8B and 8C, the steerable endoscope 800 is withdrawn proximally along the pathway leaving behind the ablation device 815. Finally, in FIG. 8D, the ablation device 815 is completely deployed about the pulmonary veins in the desired deployment pathway created by the steerable endoscope 800. At this point a number of options are available in procedure 600. The endoscope 800 may be withdrawn during the treatment that utilizes the ablation device 815. The endoscope 800 may be utilized to visually inspect the position and orientation of each ablation element distributed along the ablation device 815 in those embodiments where the ablation device 815 comprises a plurality of ablation elements. In this illustrated embodiment, the ablation device 815 has been illustrated as a single ablation element for ease of illustration. The endoscope may also be utilized to ensure the ablation device 815 has been properly deployed into the desired position to facilitate treatment. In addition, the endoscope may be utilized to visually inspect any fasteners or other adhesives or affixing means used to maintain the position of the ablation device 815 relative to the pulmonary veins.



FIG. 9 shows an embodiment of a treatment device having a plurality of fasteners to facilitate contact between the treatment device and the surrounding tissue. An endoscopic device 900 has a controllable, steerable end 905 positioned to deploy or facilitate the deployment of an ablation device 915. The ablation device 915 has a plurality of ablation elements 920. The ablation device 915 also has a plurality of fasteners 925 to increase the contact between the ablation device 915 and the surrounding tissue, organ or body portion to facilitate ablation therapy. Note the position of the fasteners 925 relative to the ablation elements 920 to provide maximum contact between and to ensure the location of the ablation elements 920 relative to the surrounding tissue. The fasteners 925 may be in other positions and may also be of other configurations and type described elsewhere in this application and/or as known to those of ordinary skill in the art.


In another embodiment of the steerable endoscope 900, the fasteners 925 could be configured such that as the steerable tip 905 is withdrawn proximally, the fastener 925 engages the surrounding tissue to secure the position of the ablation device 915. Once the ablation device 915 is positioned, the ablation treatment proceeds as desired. When the ablation treatment is complete, the steerable endoscope 900 is advances proximally from the distal end of the ablation device 915. As the steerable endoscope tip 905 advances distally past a fastener 925, the fasteners 925 along with the ablation device 915 are withdrawn into the steerable endoscope 900. It is to be appreciated that any of a wide variety of fasteners may be utilized to engage with the surrounding tissue. For example, the fasteners 925 could be formed from superelastic or shape memory alloy material. The properties of the shape memory alloy material could be selected such that the thermal energy of the body temperature is used to engage the fastener with the surrounding tissue. Alternatively, the shape memory alloy fasteners could be selectively actuated to release the shape memory effect to engage with the surrounding tissue. Engagement with the tissue includes fasteners that do not break the surface of the tissue as well as fasteners that do break the surface of the tissue. While some fasteners may disengage from the surrounding tissue through the movement of the steerable endoscope, it is to be appreciated that a tool or element may be present on or in the distal end of the endoscope 900 to facilitate the disengagement of the fastener from the surrounding tissue.



FIGS. 10A and 10B show additional examples of the endoscopic device advanced about the posterior region of a heart to facilitate treatment of a supraventricular tachycardia (FIG. 10A) and a combination of supraventricular and ventricular tachycardia (FIG. 10B). In a specific example, FIG. 10A shows another variation 600 of treating atrial fibrillation where the device may be steered and configured to loop in a continuous manner about the pulmonary vessels in a first encirclement 602 over the left pulmonary vessels LPV and a second encirclement 604 over the right pulmonary vessels RPV. The encircled portions 602, 604 of the endo scope 212 may be activated to ablate the heart tissue only around the pulmonary vessels LPV, RPV or alternatively, it may be activated to ablate the heart tissue along the entire length of both distal portion 214 and proximal portion 216. Moreover, a variety of ablation devices may be delivered to the desired areas, as described above.


In another specific example, FIG. 10B shows another variation 650 of treating atrial fibrillation where the device may be steered and configured to loop in a continuous manner about the pulmonary vessels in a first encirclement 602 over the left pulmonary vessels LPV and a second encirclement 652 over the right pulmonary vessels RPV and then across a portion of the ventricle (654). The encircled portions 602, 652, 654 of the endoscope 212 may be activated to ablate the heart tissue around the pulmonary vessels LPV, RPV and the ventricular portion adjacent 654. Alternatively, it may be activated to ablate the heart tissue along the entire length of both distal portion 214 and proximal portion 216. Moreover, a variety of ablation devices may be delivered to the desired areas, as described above.



FIG. 11 shows yet another example of a treatment for atrial fibrillation using the endoscopic device. In a specific embodiment, FIG. 11 shows yet another variation 700 in which the endoscope 216 may be advanced and steered to contact the portions of tissue posteriorly adjacent to the pulmonary vessels LPV, RPV such that an encircled region is formed 702. As illustrated, embodiments of the steerable endoscope of the present invention may be positioned about a portion of the coronary vasculature or other coronary landmarks to facilitate treatments of the heart. In this specific example, the endoscope 216 has been maneuvered using the techniques described herein into a position interior and adjacent the pulmonary veins and extended towards the inferior vena cava. The extreme configurability and controllability of the space and position of steerable endoscopes of the present invention enable placement of therapeutic devices, elements and systems about the heart and elsewhere within the body to facilitate treatment.



FIGS. 12A and 12D illustrate additional alternative embodiments of steerable endoscopic devices of the present invention advanced about the posterior region of a heart to facilitate treatment of a supraventricular tachycardia and/or combinations of supraventricular and ventricular tachycardia. As described above with regard to FIGS. 10A and 10B, the left pulmonary veins (LPV) and right pulmonary veins (RPV) are used as landmarks for purposes of illustration and discussion and not limitation. FIG. 12A illustrates an endoscopic device 1200 positioned about both the LPV and RPV and encircling one of the LPV and then proceeding anteriorly across a ventricular portion of the heart 1205. FIG. 12B illustrates an endoscopic device 1200 positioned about both the LPV and RPV and encircling one of the LPV and then proceeding laterally across a ventricular portion of the heart 1210. FIG. 12C illustrates an endoscopic device 1200 positioned about both the LPV and RPV, partially encircling the LPV and then proceeding anteriorly across a ventricular portion of the heart 1205. FIG. 12D illustrates an embodiment of the present invention where two endoscopic devices 1250 and 1260 are utilized to facilitate an ablation therapy. The first steerable endoscopic device 1250 is positioned laterally across the heart and partially encircling a LPV and a RPV. The second endoscopic device 1260 is positioned adjacent a LPV, encircling a RPV and then proceeding anteriorly across a ventricular surface of the heart 1205. It is to be appreciated that the first steerable endoscope 1250 may be used to facilitate a first ablation therapy at the same time, subsequent to or in a sequence with a second ablation therapy facilitated by the second steerable endoscope 1260. As these illustrative embodiments demonstrate, the steerable endoscopes of the present invention may be deployed in a wide variety of circumstances to facilitate an ablation therapy.



FIG. 13 shows an embodiment of a dual, steerable endoscope 1300 of the present invention utilized to facilitate treatment of the heart. The dual steerable endoscope 1300 includes a first steerable endoscope 1305 and a second steerable endoscope 1310 disposed within the first steerable endoscope 1305. In one embodiment, both endoscopes 1305, 1310 are articulated to an initial condition (I). Thereafter, the second endoscope 1310 proceeds along the pathway (a) through (i) to encircle the LPV, RPV and then proceed across a ventricular portion of the heart. The second endoscope 1310 may proceed along the pathway under control of a user. Alternatively, the second endoscope 1310 may proceed along the pathway by automatically deploying based upon any or a combination of pre-surgical planning imagery, real time imagery, mapping system receiving inputs from a detection or tracking system. In another alternative, the second endoscope 1310 proceeds using a combination of automatic controls and user input.


While described above in an application for treating the heart, it is to be appreciated that the first and second steerable endoscopes may be utilized to access portions of the neurovasculature, and other regions by maintaining the size of the second steerable endoscope to be much less than the size of the first endoscope. For example, the first endoscope may positioned in a first position, affixed in that position to act as a stable platform and/or datum for the second steerable endoscope. From that stable base, the second endoscope may be deployed to facilitate treatments.



FIGS. 14A to 14C shows side and end views, respectively, of various electrode configurations on the endoscope for tissue ablation treatment. The endoscope 900 may be configured with a number of elements, devices or systems to facilitate treatment. In one specific embodiment, a steerable endoscope of the present invention may have a plurality of electrodes disposed along its outer surface to facilitate the tissue ablation along the length, or selected regions of length, of the endoscope, as shown as described herein. The figure shows the steerable distal portion 904 and part of the automatically controllable proximal portion 902 as one example of electrode placement over the endoscope 900. As seen, one or any number of electrodes 906 may be circumferentially positioned, e.g., ring-shaped, along the length of endoscope 900 at intervals. The electrodes 906 are shown positioned at uniform intervals in this variation; however, they may be configured in any random, arbitrary, or specified locations over the outer surface of the endoscope 900. Each of the electrodes 906 may be electrically connected via corresponding wires 908 to a power supply and/or controller. Thus, all the electrodes 906 may be configured to operate simultaneously or to operate only selected electrodes 906 which may be in contact with tissue. In yet another variation, various ablation devices may be delivered to the desired areas, again as described above.



FIG. 14B shows another variation in endoscope 910 in which electrodes 916 may be configured to extend longitudinally over the proximal portion 912 and/or distal portion 914. The electrodes may be configured to extend in a continuous strip along the endo scope length or the electrodes 916 may be alternatively configured to extend in a segmented manner longitudinally over the endoscope 910, as shown. Having segmented electrodes 916 may allow for selected electrodes to be activated during tissue ablation. Although FIG. 14B shows a single line of electrodes 916 for illustration purposes, multiple lines of electrodes may be positioned over the outer surface of the device, as shown in the example of FIG. 14C, which illustrates multiple lines of electrodes 918 spaced uniformly around the circumference of the endoscope surface.


These examples described above are intended to be illustrative and are not intended to be limiting. Any number of other configurations may be accomplished with the endoscopic device due to the ability of the device to steer and configure itself such that excessive contact with surrounding tissue is avoided. Moreover, access to any number of various regions within the thoracic cavity with minimal or no damage to surrounding tissue and organs may be accomplished using the controllable endoscopic device above. Other examples for treatment using the endoscope may include, but not limited to, lead placement, implantable device placement, treatment on the lungs such as emphysema treatments, etc.


Depending upon the treatment being facilitated, it may be advantageous to increase the degree of contact or ensure the position between the treatment tool, element, or device and the tissue, organ or portion of the body receiving the treatment. Examples of means for increasing contact or affixing the position of a treatment device include: biocompatible adhesives, glues and gels either alone or in combination with staples, suction, wires, barbed and barb-less hooks or hook shaped to loop around specific anatomy. One example of a hook shaped to loop around specific anatomy includes J-shaped hooks to loop, at least partially, about the coronary vasculature. For example, a J-shaped hook may be shaped and configured to at least partially encircle a pulmonary vein. In another example, wires, staples or other fastening components may be formed from shape memory alloy material such as, nitinol or other suitable, biocompatible shape memory alloy material. The shape memory alloy fastener could be held in a first or stowed condition while navigating to the site prior to facilitating treatment. Once the treatment device is positioned, the shape memory alloy fastener could be activated and use the shape memory effect to affix the treatment device into the desired position.


In another embodiment, a steerable endoscope having a magnetic portion could be deployed about the tissue, organ or region of the body to facilitate treatment. Thereafter, the steerable endoscope could be used as a guide for the placement of an ablation system. Permanent magnets or electromagnets could be used to magnetically couple the ablation system in a desired position adjacent the steerable endoscope. Once the treatment was completed, the magnetic field is broken and the ablation system and steerable endoscope withdrawn.


In another embodiment, the steerable endoscope itself may be looped around the organ, tissue or portion of the body to undergo treatment and then secured to itself in order to facilitate treatment. Alternatively, the distal end of the endoscope could be anchored with a dissolvable suture or other dissolvable biodegradable fastener that remains in place after the ablation treatment is completed and is then absorbed into the tissue or dissolves.


In addition, an array of needles may be configured along the length or a portion of the length of the ablation device or steerable endoscope or both. In one embodiment, an array of conductive needles are arranged to improve contact between an RF ablation based delivery system and the tissue undergoing treatment. In addition to needle arrays, other suitable elements may be employed to improve the effectiveness of other ablation modalities. It is to be appreciated therefore that while needle arrays are described as increasing the effectiveness of the delivery of RF ablation energy, other elements and configurations may be used to increase the effectiveness of other ablation therapy modalities. Alternatively, for non-energy based ablation, such as ablation techniques that use lacerations of the tissue, then the elements could be any suitable device for cutting or otherwise altering the tissue to achieve a therapeutic affect.



FIGS. 15A and 15B show an embodiment of a needle array in a retracted (FIG. 15A) and a deployed (FIG. 15B) configuration. A portion of a steerable endoscope or ablation element 1500 is shown in cross section. Ablation needles 1505, 1510 are attached to backing plate 1515. The needles are maintained in the stowed configuration (FIG. 15A) with the backing plate retracted to reduce the risk of inadvertent tissue damage as the steerable endoscope or ablation system is advanced to the treatment site. In the stowed configuration, the needles 1505, 1510 remain below the steerable endoscope or ablation element exterior surface 1502. Once in position, the backing plate 1515 is advanced to the deployed condition (FIG. 15B). In the deployed position, the needles 1505, 1510 protrude beyond the steerable endoscope or ablation element exterior surface 1502. When positioned in the body for treatment, the needles 1505, 1510 would make suitable contact with the surrounding tissue, organ or body portion to facilitate treatment.


It is to be appreciated that the backing plate may be moved between the retracted and deployed configuration utilizing any of a number of techniques. Examples of such techniques and methods include mechanical drives, hydraulics, motors, actuators, permanent magnets, electromagnets, spring loaded actuators, vacuum, or other conventional actuation means. Alternatively, the actuation means could be any suitable actuation force capable of displacing the backing plate 1515 to urge a portion or all of a needle array from a retracted position into a deployed position and hence into suitable contact with the organ, tissue or body portion to receive treatment.


In an alternative embodiment, the backing plate 1515 could be continuously biased outwardly, here, outwardly indicates a position where the needles would move into a deployed configuration. The ablation element or steerable endoscope having the needle array could be covered with a moveable sheath. Once the ablation element or moveable endoscope is in the desired position, the sheath is retracted releasing the backing plate bias and allowing the needles to move into a deployed configuration.


The illustrated embodiment illustrates a pair of needles in cross section. There may be additional needles arranged adjacent and similarly disposed as the needles 1505, 1510. The additional needles may be, for example, arrayed in a regular continuous pattern as in FIG. 16. Alternatively, a single needle or array on continuous, discontinuous or random arrangement of needles may be used. In other configurations, more than teo needles may be used. The illustrated needles 1505, 1510 have a separation angle ϕ1. The separation angle may vary from 0 to 180 degrees in one embodiment, from 0 to 70 degrees in another embodiment or from 0-30 degrees in yet another embodiment depending upon application. In multiple needle applications (i.e., needle arrays having two or more separation angles), the needles may have a regular separation angle meaning that the needles are at regular angular intervals. Alternatively, the needles in a multiple needle configuration may be placed in non-regular or variable separation angles.


In addition to the angular placement of the needles in a needle array, the spacing between needles may also be continuous or variable. The needles may be arranged into a single continuous segment with uniform spacing. Such a uniform array of needles is illustrated in FIG. 16. The ablation element or steerable endoscope section configured for ablation 1600 is shown in FIG. 16. Needles 1610 are shown in a single segment or grouping of needles 1605.



FIG. 17 shows an embodiment of a needle array segment 1700 having three sections (1705, 1710 and 1715) showing a variety of needle spacing configurations. The needle array segment 1700 illustrates how a nearly limitless variety of spacing configurations may be combined to obtain a desired needle array configuration to facilitate an ablation treatment. Section 1705 includes an upper array of needles 1726, 1728 and 1730 aligned in a continuous uniform fashion above a lower array of needles 1720, 1722 and 1724. This configuration is similar to section 1600 in FIG. 16. Like section 1705; the upper array of section 1710 has evenly spaced needles 1732, 1734 and 1736. The lower array of needles have only one needle aligned to the upper array. Needle 1738 is aligned with needle 1732. There is no needle in the lower array that corresponds to needle 1736. A plurality of needles (1740, 1741 and 1742) are spaced across from upper array needle 1734. The section 1710 illustrates how there may be needle to needle correspondence (1732, 1738), no correspondence (1736) or one to many correspondence (1734, 1740, 1741, 1742) between the needles in the upper and lower arrays of a section.


Section 1715 further illustrates the configurability of the needle arrangements. Both the upper needles 1750, 1752, 17541756 and lower needles 1766, 1768, 1770, 1771, 1772, 1773 illustrate variable spacing. In addition, there is no alignment between the upper and lower arrays. In addition, section 1715 illustrates a middle array having upper needles 1758, 1760 spaced apart from lower needles 1762, 1764. In the illustrated embodiment, the upper and lower needles are aligned but that need not be the case in all embodiments. Additionally, the middle array is illustrated without alignment to the upper array and the lower array. This need not be the case in all embodiments. In some embodiments, the middle array may be aligned with all or part of either a lower or an upper array. Accordingly, a needle pattern within a section could be predetermined and selected to facilitate a desired ablation treatment. Moreover, using pre-surgical planning techniques, the type, number, amount and ablation pattern could be predetermined and an appropriate combination of segments, sections and needles arrays could be loaded into a steerable endoscope or otherwise delivered utilizing a steerable endoscope to facilitate treatment.



FIGS. 18A and 18B show a side and isometric view of an embodiment of a tunable treatment device of the present invention. The tunable treatment device 1800 includes an ablation element 1810 within a housing 1805. The housing 1805 also includes an opening 1815 that allows the energy generated by the ablation element 1810 to pass outside of the housing. The opening 1815 is fitted with a cover 1820 that forms a seal between the environment the tunable treatment device 1800 is positioned in and the interior of the housing 1805. In one embodiment, the housing 1805 is made of a first material and the cover 1820 is made of a second material. With respect to the energy generated or provided by the ablation element 1810, the first material transmits less of the energy generated by the ablation element 1810 than the second material. In another embodiment, the first material acts as a shield separating the ablation energy generated by the ablation element and the surrounding environment. The second material acts as a transmission window or opening in an otherwise shielded housing. The transmission window or opening thus allows energy provided by the ablation element to be selectively passed via the opening into the tissue, organ or environment positioned adjacent the cover 1820. Thus, the advantageous combination of shielding and openings allow for more precise delivery of the ablation energy to the desired tissue, organ or location while shielding the surrounding area from the ablation energy.


The tunable ablation delivery device 1800 is also provided with a detector 1830 for detecting a physiological indication useful in administering the ablation therapy. The detector 1830 may comprise a plurality of detection elements arrayed about the housing 1805. In the illustrated embodiment, the detector 1830 includes a plurality of detection elements 1835. The detection elements 1835 are arranged at regular intervals about the perimeter of the housing 1805. A reading may be obtained from each element and then analyzed to determine which element or elements obtained the best reading for the physiological parameter being measured. Once that determination is made, the tunable ablation device 1800 may then be oriented to place the opening 1815 into position to facilitate ablation treatment.


In one specific example, the tunable ablation delivery device 1800 may be modified to facilitate an ablation treatment on the pericardium of the heart. In this example, the detection elements 1835 may be elements capable of detecting electrophysiological (EP) activity. For example, the detection elements 1835 could detect electrophysiological (EP) activity by detecting ECG activity. An example of the readings and/or signal strength obtained by each detector 1835 is illustrated in FIG. 19. FIG. 19 shows a graph illustrating a technique to optimize placement of a tunable ablation device to facilitate therapy. Using conventional software, hardware and optimization techniques, the detection elements 1835 may be used to localize the position, relative to the housing 1805, where the desired amount of physiological indication occurs. In the graph 1900 the desired activity is the peak EP activity. According to the graph 1900, the peak EP activity occurs in proximity to sensor position 5. This information can then be used by the control system that articulates, rotates, translates or otherwise positions the tunable ablation element 1800 to position the tunable ablation element 1800 into a position that facilitates an ablation treatment in the vicinity of sensor 5. In the specific embodiment illustrated in FIGS. 18A and 18B, the tunable ablation device 1800 would be rotated under the control of a control system having the relative position and orientation of the plurality of elements 1835 and the opening 1815 and ablation element 1810. The tunable ablation device 1800 would be rotated under the control of a control system using for example, the engagement element 1845, to align the opening 1815 and/or cover 1820 into the orientation of sensor 5.


An example of how a plurality of tunable ablation elements may be advantageously deployed to increase the effectiveness of an ablation therapy will now be described with reference to FIGS. 18C and 18D. Three tunable ablation elements 1800A, 1800B and 1800C are positioned within a steerable endoscope 212 of the present invention. In FIG. 18C the three ablation elements have reached the deployment point for ablation element 1800A. Note that in the initial position before optimizing any of the tunable ablation elements 1800A, B or C, the windows 1820 are aligned. As described above the detectors 1830 on ablation element 1800A are used to improve the effectiveness of the ablation element within the tunable ablation element 1800A by indicating a desired position for applying the ablation therapy. As shown in FIG. 18B, the determined position of the element 1800A is when the window 1820 rotated into a slightly upward position from the initial position. Additionally, the mechanical linkage 1845 has been disengaged so that the control cable/component 1880 no longer rotates the element 1800A. In addition, the fixation elements for element 1800A have been omitted for clarity but have engaged to fix the position of element 1800A. FIG. 18D also illustrates how the controller cable/component 1880 has utilized the detector 1830 onboard element 1800B to optimize the position of the window 1820. Note that the window 1820 for element 1800B is rotated downward. At this point, the fixation elements for element 1800B are engaged to fix the position of the element 1800B. Thereafter, the linkage 1845 for element 1800B is released so that element 1800C may be positioned and then optimized as described herein for elements 1800A and 1800B. Accordingly, there are configurations of the tunable ablation elements where the windows of adjacent ablation elements are not in alignment but rather reflect an alignment of localized optimization for that ablation element.


In an alternative embodiment, the detector for detecting a physiological indication could also be a single detector. The single detector could be actuated to move about the surface of the tunable ablation delivery device 1800 measuring the indication. The obtained measurements could then be used to assist in positioning the ablation element 1810 and opening 1815 to facilitate treatment. In one specific embodiment, the single detector could move about the perimeter of the tunable ablation device and provide strength of indication relative to position information similar to FIG. 19.


A securing member 1840 is also provided to hold the tunable ablation device 1800 in the desired position during the readings from the indicator elements 1835, or after rotation of the ablation device into the desired position for facilitating treatment. In the illustrated embodiment, the securing member 1840 may be a vacuum manifold 1855 having a plurality of suction ports 1860. In a preferred embodiment, the securing means is releasable from the surrounding tissue, organ or region of interest to facilitate movement to align the ablation element for treatment or for easy removal once the treatment is complete.


The endoscope device may also be utilized for procedures within the peritoneal cavity. Potential applications may include minimally invasive surgery for urologic, bariatric, and liver surgery. Moreover, minimally invasive access may be achieved for treatments in spinal or orthopedic surgery as well. FIG. 20 shows an example of a procedure 2000 within the peritoneal cavity which may be performed with the endoscopic device. FIG. 20 shows an example of a procedure 2000 within the peritoneal cavity using the endoscopic device 212. The endoscope 212 may be introduced into patient 2002 through an incision 2008 via a port, which may also function as a datum 2006, as described above. The distal portion 214 may be steered to avoid various organs while being 2004. The distal portion 214 of the endoscope 212 may accordingly be steered while the proximal portion 216 may be automatically controlled to follow a path defined by the distal portion 214 which minimizes contact with the surrounding and adjacent tissue and organs. One or more laparoscopes 2010 may optionally be used in combination with the endoscope 212 to assist with the surgical procedure. Once the distal portion 214 is posteriorly positioned of the liver 2004, various tools or treatment devices may be advanced through the endoscope 212 from the proximal end to effect the desired treatment. Although this example shows treatment of the liver 2004 using the endoscope 212, this is intended to be illustrative of other organs or procedures that may be effectively treated utilizing embodiments of the endoscope 212.


As the above discussion illustrates, steerable endoscopic systems of the present invention may be advantageously utilized to facilitate a wide variety of procedures. When utilized to facilitate an ablation therapy, the ablation element, device or system may be part of the segmented steerable endoscope, deployed within a working channel or other passage created by the steerable endoscope, or a combination of fixed and moveable treatment elements, device or systems. Accordingly, steerable endoscopes of the present invention may, in one embodiment, facilitate treatment by deploying an ablation element, device or system affixed to the endoscope to a treatment location in a treatment position. The endoscope remains in place during the treatment and, when complete, retracts from the treatment position.


In another variation, the steerable endoscope is utilized to deploy and/or inspect the placement of a treatment device, is then withdrawn while the treatment proceeds. Thereafter, the steerable endoscope retrieves the treatment device. In yet another variation, the steerable endoscope may be inserted into a treatment area into a desired treatment pathway. Next, the steerable endoscope is retracted to leave the treatment device in place along the desired treatment pathway. The steerable endoscope may remain in place for visualization of the treatment as it proceeds, monitor a physiological indication or otherwise support the treatment. Alternatively, the steerable endoscope may withdraw from the treatment area or completely from the body. After the treatment is complete, the steerable endoscope may be advanced along the treatment device to remove/store the treatment device as the endoscope proceeds distally along the treatment device. Once the treatment device has been collected into the endoscope, the endoscope is withdrawn. Accordingly, there have been shown various ways to position a treatment element, device or system within a body, affix or otherwise maintain the position of the treatment device relative to the area or areas of treatment to increase the effectiveness of the treatment or therapy being performed.


Separately or in combination with the techniques described above, various imaging and control systems may be used to facilitate control of the steerable endoscope. For example, the steerable endoscope may proceed along and envelope a deployed treatment device utilizing a recorded pathway to retrace steps used to place the treatment device. The steerable endoscope may also track a way point set to indicate the next fastener where the fastener is in a preprogrammed position, in a position identifiable using an imaging system or the fastener is otherwise configured for easy identification, such as through use of an RPID, for example. The steerable endoscope may also use an imaging system for guidance in recovering a treatment device. The steerable endoscope may also utilize fly by wire techniques to fly by wire using the treatment device as the wire. In yet another embodiment, the treatment device could be automatically withdrawn into the steerable endoscope using mapping, imaging or other system controls to retrace track or otherwise dislodge or disengage the treatment device from the internal position to perform a treatment.


Embodiments of the present invention may also include tools, devices or systems to pierce, lacerate, cut, puncture, or otherwise provide a passage or controlled perforation of tissue to allow access of the steerable, guided endoscope into the region of interest. In a neurological application for accessing the brain, such a device would be suited for creating a suitable opening in the dura for example. In a cardiovascular application for accessing the heart, such a device would be suited for creating a suitable opening in the pericardium for example. The tools, devices or systems to pierce, lacerate, cut, puncture, or otherwise provide a passage or controlled perforation to enable passage of the endoscope may be disposed permanently on the distal end of the scope. Alternatively, the tools, devices or systems may be mounted on the distal end of the endoscope but be positionable between a retracted and extended position to help minimize the risk of inadvertent damage while the endoscope is moving within the body to the region of interest. In another alternative, the tools, devices or systems may be provided conventionally via a working channel in the endoscope. Examples of the tools, devices or systems include scissors, electrocautery devices and systems, small snips, shaped blades and shaped tips.


While embodiments of the present invention have been shown and described as dispensing treatment within the brain, cranial interior, the interior of the heart, the exterior of the heart, it is to be appreciated that embodiments of the methods and apparatus of the present invention may be used in other applications as well. For example, embodiments of the invention may be used to facilitate treatment of disorders of other organs and portions of the body, for example, the stomach, the gastrointestinal tract, the esophagus, the bladder, the liver, the kidneys and the lungs. Additionally, embodiments of the present invention may be used to facilitate treatment of localized disorders within the body, portions of the body or a disorder of a physiological system.


The applications of the devices and methods discussed above are not limited to regions of the body but may include any number of further treatment applications. Other treatment sites may include other areas or regions of the body. Additionally, the present invention may be used in other industrial and commercial environments such as exploratory procedures on piping systems, ducts, internal inspection of mechanical systems including automotive, aeronautical, aerospace, and marine systems and equipment, etc. Modification of the above-described assemblies and methods for carrying out the invention, and variations of aspects of the invention that are obvious to those of skill in the art are attended to within the scope of the claims.

Claims
  • 1. A surgical system comprising: a first elongate device and a second elongate device, each of the first elongate device and the second elongate device having a steerable distal portion and a proximal portion, wherein the second elongate device is disposed at least partially within the first elongate device and is configured to extend and retract relative to the first elongate device;a position system comprising a sensor configured to sense a position of at least one of the first elongate device and the second elongate device; anda controller configured to: receive user input,receive sensed position information from the positioning system,receive information identifying a location within a body, andcontrol movement of at least one of the first elongate device and the second elongate device along a pathway to reach the location in the body based on the user input and the received sensed position information, andmaintain a portion of the at least one of the first elongate device and the second elongate device at the location.
  • 2. The surgical system of claim 1, wherein the controller is further configured to automatically maintain the portion of the at least one of the first elongate device and the second elongate device at the location.
  • 3. The surgical system of claim 1, wherein the sensor of the positioning system is configured to produce a signal indicative of the location of the portion of the at least one of the first elongate device and the second elongate device with regard to a point of reference.
  • 4. The surgical system of claim 1, wherein the controller is further configured to receive image data correlating the location within the body and a frame of reference.
  • 5. The surgical system of claim 1, wherein the sensor of the position system is configured to detect a change in position of the at least one of the first elongate device and the second elongate device.
  • 6. The surgical system of claim 1, wherein the controller is further configured to control the movement of the at least one of the first elongate device and the second elongate device to maintain the at least one of the first elongate device and the second elongate device in a predetermined fixed position.
  • 7. The surgical system of claim 1, wherein the surgical system further comprises an imaging device to image the location within the body.
  • 8. The surgical system of claim 1, wherein the controller is further configured to record the movement of the at least one of the first elongate device and the second elongate device along the pathway.
  • 9. The surgical system of claim 1, wherein the information identifying the location within the body is chosen from at least one of position, location, tissue type, and disease state.
  • 10. The surgical system of claim 1, wherein the first elongate device and the second elongate device each comprise steerable endoscopes.
  • 11. The surgical system of claim 1, wherein the second elongate device is configured to traverse along a path defined at least partially within the first elongate device.
  • 12. The surgical system of claim 11, wherein the controller is further configured to control the movement of the second elongate device traversing along the path defined within the first elongate device.
  • 13. The surgical system of claim 1, wherein the controller is configured to maintain the position of the first elongate device while the second elongate device extends from the first elongate device to perform a treatment within the body at the location.
  • 14. The surgical system of claim 1, wherein the sensor comprises a motion transducer configured to measure at least one of axial and rotational displacement of the at least one of the first elongate device and the second elongate device.
  • 15. The surgical system of claim 1, wherein the second elongate device comprises a surgical tool to perform a surgical procedure.
  • 16. The surgical system of claim 15, wherein the surgical tool comprises an ablation element.
CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 15/229,177 (filed Aug. 5, 2016), which is a continuation of U.S. patent application Ser. No. 13/962,264 (filed Aug. 8, 2013; now U.S. Pat. No. 9,427,282), which is a divisional application of U.S. patent application Ser. No. 10/850,360 (filed May 19, 2004; now U.S. Pat. No. 8,517,923), which is a continuation-in-part of U.S. patent application Ser. No. 10/767,109 (filed Jan. 28, 2004; now abandoned), which was a continuation in-part of U.S. patent application Ser. No. 10/228,583 (filed Aug. 26, 2002; now U.S. Pat. No. 6,869,396), which is a continuation of U.S. application Ser. No. 09/790,204 (filed Feb. 20, 2001; now U.S. Pat. No. 6,468,203), which claims the benefit of priority from U.S. Provisional Patent Application No. 60/194,140 (filed Apr. 3, 2000), each of which is incorporated herein by reference in its entirety.

US Referenced Citations (516)
Number Name Date Kind
616672 Kelling Dec 1898 A
1590919 Wahl et al. Jun 1926 A
2241576 Charles May 1941 A
2510198 Tesmer Jun 1950 A
2533494 Mitchell, Jr. Dec 1950 A
2767705 Moore Oct 1956 A
3060972 Sheldon Oct 1962 A
3071161 Ulrich Jan 1963 A
3096962 Meijs Jul 1963 A
3162214 Wilfred, Jr. Dec 1964 A
3168274 Street Feb 1965 A
3190286 Stokes Jun 1965 A
3266059 Stelle Aug 1966 A
3430662 Guarnaschelli Mar 1969 A
3497083 Victor et al. Feb 1970 A
3546961 Marton Dec 1970 A
3610231 Takahashi et al. Oct 1971 A
3625084 Siebert Dec 1971 A
3643653 Nagashige et al. Feb 1972 A
3739770 Mori Jun 1973 A
3773034 Burns et al. Nov 1973 A
3780740 Rhea Dec 1973 A
3858578 Milo et al. Jan 1975 A
3871358 Fukuda Mar 1975 A
3897775 Furihata Aug 1975 A
3913565 Kawahara Oct 1975 A
3946727 Okada et al. Mar 1976 A
3990434 Free Nov 1976 A
4054128 Seufert et al. Oct 1977 A
4176662 Frazer Dec 1979 A
4233981 Schomacher Nov 1980 A
4236509 Takahashi et al. Dec 1980 A
4240435 Yazawa et al. Dec 1980 A
4272873 Dietrich Jun 1981 A
4273111 Tsukaya Jun 1981 A
4286585 Ogawa Sep 1981 A
4327711 Takagi May 1982 A
4366810 Slanetz, Jr. Jan 1983 A
4393728 Larson et al. Jul 1983 A
4418688 Loeb Dec 1983 A
4432349 Oshiro Feb 1984 A
4483326 Yamaka et al. Nov 1984 A
4489826 Dubson Dec 1984 A
4494417 Larson et al. Jan 1985 A
4499895 Takayama Feb 1985 A
4503842 Takayama Mar 1985 A
4517652 Bennett et al. May 1985 A
4534339 Collins et al. Aug 1985 A
4543090 McCoy Sep 1985 A
4551061 Olenick Nov 1985 A
4559928 Takayama Dec 1985 A
4566843 Iwatsuka et al. Jan 1986 A
4577621 Patel Mar 1986 A
4592341 Omagari et al. Jun 1986 A
4601283 Chikama Jul 1986 A
4601705 McCoy Jul 1986 A
4601713 Fuqua Jul 1986 A
4621618 Omagari Nov 1986 A
4624243 Lowery et al. Nov 1986 A
4630649 Oku Dec 1986 A
4643184 Mobin-Uddin Feb 1987 A
4646722 Silverstein et al. Mar 1987 A
4648733 Merkt Mar 1987 A
4651718 Collins et al. Mar 1987 A
4655257 Iwashita Apr 1987 A
4683773 Diamond Aug 1987 A
4686963 Cohen et al. Aug 1987 A
4696544 Costella Sep 1987 A
4712969 Kimura Dec 1987 A
4726355 Okada Feb 1988 A
4753222 Morishita Jun 1988 A
4753223 Bremer Jun 1988 A
4754909 Barker et al. Jul 1988 A
4784117 Miyazaki Nov 1988 A
4787369 Allred, III et al. Nov 1988 A
4788967 Ueda Dec 1988 A
4790624 Van Hoye et al. Dec 1988 A
4793326 Shishido Dec 1988 A
4796607 Allred, III et al. Jan 1989 A
4799474 Ueda Jan 1989 A
4800890 Cramer Jan 1989 A
4807593 Ito Feb 1989 A
4815450 Patel Mar 1989 A
4832473 Ueda May 1989 A
4834068 Gottesman May 1989 A
4846573 Taylor et al. Jul 1989 A
4873965 Danieli Oct 1989 A
4873990 Holmes et al. Oct 1989 A
4879991 Ogiu Nov 1989 A
4884557 Takehana et al. Dec 1989 A
4890602 Hake Jan 1990 A
4895431 Tsujiuchi et al. Jan 1990 A
4899731 Takayama et al. Feb 1990 A
4904048 Sogawa et al. Feb 1990 A
4917114 Green et al. Apr 1990 A
4919112 Siegmund Apr 1990 A
4930494 Takehana et al. Jun 1990 A
4949927 Madocks et al. Aug 1990 A
4957486 Davis Sep 1990 A
4969709 Sogawa et al. Nov 1990 A
4971035 Ito Nov 1990 A
4977886 Takehana et al. Dec 1990 A
4977887 Gouda Dec 1990 A
4987314 Gotanda et al. Jan 1991 A
5005558 Aomori Apr 1991 A
5005559 Blanco et al. Apr 1991 A
5014709 Bjelkhagen et al. May 1991 A
5018509 Suzuki et al. May 1991 A
5025778 Silverstein et al. Jun 1991 A
5025804 Kondo Jun 1991 A
5050585 Takahashi Sep 1991 A
5059158 Bellio et al. Oct 1991 A
5060632 Hibino et al. Oct 1991 A
5083549 Cho et al. Jan 1992 A
5090956 McCoy Feb 1992 A
5092901 Hunter et al. Mar 1992 A
5103403 Chhayder et al. Apr 1992 A
5125395 Adair Jun 1992 A
5127393 McFarlin et al. Jul 1992 A
5159446 Hibino et al. Oct 1992 A
5166787 Irion Nov 1992 A
5174276 Crockard Dec 1992 A
5174277 Matsumaru Dec 1992 A
5179935 Miyagi Jan 1993 A
5188111 Yates et al. Feb 1993 A
5203319 Danna et al. Apr 1993 A
5207695 Trout, III May 1993 A
5217001 Nakao et al. Jun 1993 A
5218280 Edwards Jun 1993 A
5220911 Tamura Jun 1993 A
5228429 Hatano Jul 1993 A
5234448 Wholey et al. Aug 1993 A
5239982 Trauthen Aug 1993 A
5243967 Hibino Sep 1993 A
5250058 Miller et al. Oct 1993 A
5250167 Adolf et al. Oct 1993 A
5251611 Zehel et al. Oct 1993 A
5253647 Takahashi et al. Oct 1993 A
5254809 Martin Oct 1993 A
5257617 Takahashi Nov 1993 A
5259364 Bob et al. Nov 1993 A
5268082 Oguro et al. Dec 1993 A
5269289 Takehana et al. Dec 1993 A
5271381 Ailinger et al. Dec 1993 A
5271382 Chikama Dec 1993 A
5279610 Park et al. Jan 1994 A
5297443 Wentz Mar 1994 A
5299143 Hellinga Mar 1994 A
5324284 Imran Jun 1994 A
5325845 Adair Jul 1994 A
5337732 Grundfest et al. Aug 1994 A
5337733 Bauerfeind et al. Aug 1994 A
5343874 Picha et al. Sep 1994 A
5347987 Feldstein et al. Sep 1994 A
5348259 Blanco et al. Sep 1994 A
5368015 Wilk Nov 1994 A
5370108 Miura et al. Dec 1994 A
5377678 Dumoulin Jan 1995 A
5383467 Auer et al. Jan 1995 A
5383852 Stevens-Wright Jan 1995 A
5389222 Shahinpoor Feb 1995 A
5394864 Kobayashi et al. Mar 1995 A
5396879 Wilk et al. Mar 1995 A
5400769 Tanii et al. Mar 1995 A
5402768 Adair Apr 1995 A
5411508 Bessler et al. May 1995 A
5413108 Alfano May 1995 A
5421337 Richards-Kortum et al. Jun 1995 A
5421338 Crowley et al. Jun 1995 A
5425738 Gustafson et al. Jun 1995 A
5429118 Cole et al. Jul 1995 A
5431645 Smith et al. Jul 1995 A
5439000 Gunderson et al. Aug 1995 A
5451221 Cho et al. Sep 1995 A
5456714 Owen Oct 1995 A
5460166 Yabe et al. Oct 1995 A
5460168 Masubuchi et al. Oct 1995 A
5469840 Tanii et al. Nov 1995 A
5479930 Gruner et al. Jan 1996 A
5482029 Sekiguchi et al. Jan 1996 A
5486182 Nakao et al. Jan 1996 A
5487385 Avitall Jan 1996 A
5487757 Truckai et al. Jan 1996 A
5489256 Adair Feb 1996 A
5492131 Galel Feb 1996 A
5503616 Jones Apr 1996 A
5507287 Palcic et al. Apr 1996 A
5507717 Kura et al. Apr 1996 A
5522788 Kuzmak Jun 1996 A
5531664 Adachi et al. Jul 1996 A
5535759 Wilk Jul 1996 A
5551945 Yabe et al. Sep 1996 A
5556370 Maynard Sep 1996 A
5556700 Kaneto et al. Sep 1996 A
5558619 Kami et al. Sep 1996 A
5558665 Kieturakis Sep 1996 A
5577992 Chiba et al. Nov 1996 A
5586968 Grundl et al. Dec 1996 A
5590660 MacAulay et al. Jan 1997 A
5601087 Gunderson et al. Feb 1997 A
5602449 Krause et al. Feb 1997 A
5620408 Vennes et al. Apr 1997 A
5624380 Takayama et al. Apr 1997 A
5624381 Kieturakis Apr 1997 A
5626553 Frassica et al. May 1997 A
5631040 Takuchi et al. May 1997 A
5645064 Littmann et al. Jul 1997 A
5645520 Nakamura et al. Jul 1997 A
5647368 Zeng et al. Jul 1997 A
5647840 Damelio et al. Jul 1997 A
5651366 Liang et al. Jul 1997 A
5651769 Waxman et al. Jul 1997 A
5653690 Booth et al. Aug 1997 A
5658238 Suzuki et al. Aug 1997 A
5662585 Willis et al. Sep 1997 A
5662587 Grundfest et al. Sep 1997 A
5662621 Lafontaine Sep 1997 A
5665050 Benecke Sep 1997 A
5667476 Frassica et al. Sep 1997 A
5679216 Takayama et al. Oct 1997 A
5681260 Ueda et al. Oct 1997 A
5704898 Kokish Jan 1998 A
5720718 Rosen et al. Feb 1998 A
5725475 Yasui et al. Mar 1998 A
5728044 Shan Mar 1998 A
5733245 Kawano Mar 1998 A
5746694 Wilk et al. May 1998 A
5749828 Solomon et al. May 1998 A
5752912 Takahashi et al. May 1998 A
5759151 Sturges Jun 1998 A
5762613 Sutton et al. Jun 1998 A
5765561 Chen et al. Jun 1998 A
5769792 Palcic et al. Jun 1998 A
5771902 Lee et al. Jun 1998 A
5772597 Goldberger et al. Jun 1998 A
5773835 Sinofsky Jun 1998 A
5779624 Chang Jul 1998 A
5807241 Heimberger Sep 1998 A
5810715 Moriyama Sep 1998 A
5810716 Mukherjee et al. Sep 1998 A
5810717 Maeda et al. Sep 1998 A
5810776 Bacich et al. Sep 1998 A
5813976 Filipi et al. Sep 1998 A
5819749 Lee et al. Oct 1998 A
5827190 Palcic et al. Oct 1998 A
5827265 Glinsky et al. Oct 1998 A
5842973 Bullard Dec 1998 A
5848972 Triedman et al. Dec 1998 A
5855565 Bar-Cohen et al. Jan 1999 A
5857962 Bracci et al. Jan 1999 A
5860581 Robertson et al. Jan 1999 A
5860914 Chiba et al. Jan 1999 A
5868760 McGuckin, Jr. Feb 1999 A
5873817 Kokish et al. Feb 1999 A
5876329 Harhen Mar 1999 A
5876373 Giba et al. Mar 1999 A
5885208 Moriyama Mar 1999 A
5893369 Lemole Apr 1999 A
5897417 Grey Apr 1999 A
5897488 Ueda Apr 1999 A
5902254 Magram May 1999 A
5906591 Dario et al. May 1999 A
5908381 Aznoian et al. Jun 1999 A
5911715 Berg et al. Jun 1999 A
5912147 Stoler et al. Jun 1999 A
5916146 Allotta et al. Jun 1999 A
5916147 Boury Jun 1999 A
5921915 Aznoian et al. Jul 1999 A
5928136 Barry Jul 1999 A
5941815 Chang Aug 1999 A
5941908 Goldsteen et al. Aug 1999 A
5957833 Shan Sep 1999 A
5957969 Warner et al. Sep 1999 A
5968052 Sullivan, III Oct 1999 A
5971767 Kaufman et al. Oct 1999 A
5976074 Moriyama Nov 1999 A
5989182 Hori et al. Nov 1999 A
5989230 Frassica Nov 1999 A
5993381 Ito Nov 1999 A
5993447 Blewett et al. Nov 1999 A
5993462 Pomeranz et al. Nov 1999 A
5996346 Maynard Dec 1999 A
6016440 Simon et al. Jan 2000 A
6033359 Doi Mar 2000 A
6036636 Motoki et al. Mar 2000 A
6036702 Bachinski et al. Mar 2000 A
6042155 Lockwood Mar 2000 A
6048307 Grundl et al. Apr 2000 A
6059718 Taniguchi et al. May 2000 A
6063022 Ben-Haim May 2000 A
6066102 Townsend et al. May 2000 A
6066132 Chen et al. May 2000 A
6068629 Haissaguerre et al. May 2000 A
6068638 Makower May 2000 A
6071234 Takada Jun 2000 A
6096023 Lemelson Aug 2000 A
6096289 Goldenberg Aug 2000 A
6099464 Shimizu et al. Aug 2000 A
6099465 Inoue Aug 2000 A
6099485 Patterson Aug 2000 A
6099524 Lipson Aug 2000 A
6106510 Lunn et al. Aug 2000 A
6109852 Shahinpoor et al. Aug 2000 A
6117296 Thomson Sep 2000 A
6119913 Adams et al. Sep 2000 A
6129667 Dumoulin et al. Oct 2000 A
6129683 Sutton et al. Oct 2000 A
6141577 Rolland et al. Oct 2000 A
6149581 Klingenstein Nov 2000 A
6162171 Ng et al. Dec 2000 A
6174280 Oneda et al. Jan 2001 B1
6174291 McMahon et al. Jan 2001 B1
6178346 Amundson et al. Jan 2001 B1
6179776 Adams et al. Jan 2001 B1
6185448 Borovsky Feb 2001 B1
6201989 Whitehead et al. Mar 2001 B1
6203493 Ben-Haim Mar 2001 B1
6203494 Moriyama Mar 2001 B1
6210337 Dunham et al. Apr 2001 B1
6221006 Dubrul et al. Apr 2001 B1
6226547 Lockhart May 2001 B1
6233476 Strommer et al. May 2001 B1
6241657 Chen et al. Jun 2001 B1
6249076 Madden et al. Jun 2001 B1
6264086 McGuckin, Jr. Jul 2001 B1
6270453 Sakai Aug 2001 B1
6293907 Axon et al. Sep 2001 B1
6306081 Ishikawa et al. Oct 2001 B1
6309346 Farhadi Oct 2001 B1
6315714 Akiba Nov 2001 B1
6319197 Tsuji et al. Nov 2001 B1
6327492 Lemelson Dec 2001 B1
6332089 Acker et al. Dec 2001 B1
6348058 Melkent et al. Feb 2002 B1
6352503 Matsui et al. Mar 2002 B1
6364876 Erb et al. Apr 2002 B1
6366799 Acker et al. Apr 2002 B1
6371907 Hasegawa et al. Apr 2002 B1
6402687 Ouchi Jun 2002 B1
6408889 Komachi Jun 2002 B1
6425535 Akiba Jul 2002 B1
6428203 Danley Aug 2002 B1
6428470 Thompson Aug 2002 B1
6443888 Ogura et al. Sep 2002 B1
6447444 Avni et al. Sep 2002 B1
6453190 Acker et al. Sep 2002 B1
6459481 Schaack Oct 2002 B1
6468203 Belson Oct 2002 B2
6468265 Evans et al. Oct 2002 B1
6482148 Luke Nov 2002 B1
6482149 Torii Nov 2002 B1
6485413 Boppart et al. Nov 2002 B1
6485496 Suyker et al. Nov 2002 B1
6490467 Bucholz et al. Dec 2002 B1
6503259 Huxel et al. Jan 2003 B2
6511417 Taniguchi et al. Jan 2003 B1
6511418 Shahidi et al. Jan 2003 B2
6514237 Maseda Feb 2003 B1
6517477 Wendlandt Feb 2003 B1
6527706 Ide Mar 2003 B2
6537211 Wang et al. Mar 2003 B1
6544215 Bencini et al. Apr 2003 B1
6547723 Ouchi Apr 2003 B1
6554793 Pauker et al. Apr 2003 B1
6569084 Mizuno et al. May 2003 B1
6569173 Blatter et al. May 2003 B1
6589163 Aizawa et al. Jul 2003 B2
6610007 Belson et al. Aug 2003 B2
6616600 Pauker Sep 2003 B2
6638213 Ogura et al. Oct 2003 B2
6641528 Torii Nov 2003 B2
6650920 Schaldach et al. Nov 2003 B2
6656110 Irion et al. Dec 2003 B1
6664718 Pelrine et al. Dec 2003 B2
6679836 Couvillon, Jr. et al. Jan 2004 B2
6690963 Ben-Haim et al. Feb 2004 B2
6699183 Wimmer Mar 2004 B1
6719685 Fujikura et al. Apr 2004 B2
6761685 Adams et al. Jul 2004 B2
6783491 Saadat et al. Aug 2004 B2
6790173 Saadat et al. Sep 2004 B2
6793621 Butler et al. Sep 2004 B2
6800056 Tartaglia et al. Oct 2004 B2
6808499 Churchill et al. Oct 2004 B1
6808520 Fourkas et al. Oct 2004 B1
6817973 Merril et al. Nov 2004 B2
6835173 Couvillon, Jr. Dec 2004 B2
6837846 Jaffe et al. Jan 2005 B2
6837847 Ewers et al. Jan 2005 B2
6837849 Ogura et al. Jan 2005 B2
6843793 Brock et al. Jan 2005 B2
6850794 Shahidi Feb 2005 B2
6858005 Ohline et al. Feb 2005 B2
6869396 Belson Mar 2005 B2
6875170 Francois et al. Apr 2005 B2
6890297 Belson May 2005 B2
6902528 Garibaldi et al. Jun 2005 B1
6942613 Ewers et al. Sep 2005 B2
6960161 Amling et al. Nov 2005 B2
6960162 Saadat et al. Nov 2005 B2
6960163 Ewers et al. Nov 2005 B2
6974411 Belson Dec 2005 B2
6984203 Tartaglia et al. Jan 2006 B2
6997870 Couvillon, Jr. Feb 2006 B2
7018331 Chang Mar 2006 B2
7044907 Belson May 2006 B2
7087013 Belson et al. Aug 2006 B2
7125403 Julian et al. Oct 2006 B2
7167180 Shibolet Jan 2007 B1
7285088 Miyake Oct 2007 B2
7297142 Brock Nov 2007 B2
7331967 Lee et al. Feb 2008 B2
7371210 Brock et al. May 2008 B2
7447534 Kingsley et al. Nov 2008 B1
8062212 Belson Nov 2011 B2
8226546 Belson Jul 2012 B2
8517923 Belson et al. Aug 2013 B2
8641602 Belson Feb 2014 B2
8721530 Ohline et al. May 2014 B2
8827894 Belson Sep 2014 B2
8834354 Belson Sep 2014 B2
8845524 Belson et al. Sep 2014 B2
8888688 Julian et al. Nov 2014 B2
9138132 Belson Sep 2015 B2
9427282 Belson et al. Aug 2016 B2
10105036 Julian et al. Oct 2018 B2
10327625 Belson et al. Jun 2019 B2
10736490 Julian et al. Aug 2020 B2
20010031983 Brock et al. Oct 2001 A1
20010041887 Crowley Nov 2001 A1
20020016607 Bonadio et al. Feb 2002 A1
20020022829 Nagase Feb 2002 A1
20020032437 Andrews et al. Mar 2002 A1
20020045778 Murahashi et al. Apr 2002 A1
20020062062 Belson May 2002 A1
20020120252 Brock et al. Aug 2002 A1
20020129508 Blattner Sep 2002 A1
20020130673 Pelrine et al. Sep 2002 A1
20020151767 Sonnenschein et al. Oct 2002 A1
20020169361 Taniguchi et al. Nov 2002 A1
20020183592 Suzuki et al. Dec 2002 A1
20030032859 Belson Feb 2003 A1
20030065373 Lovett et al. Apr 2003 A1
20030073992 Sliwa et al. Apr 2003 A1
20030083550 Miyagi May 2003 A1
20030130598 Manning et al. Jul 2003 A1
20030163128 Patil et al. Aug 2003 A1
20030167007 Belson Sep 2003 A1
20030171650 Tartaglia Sep 2003 A1
20030182091 Kukuk Sep 2003 A1
20030187460 Chin et al. Oct 2003 A1
20030195387 Kortenbach et al. Oct 2003 A1
20030233056 Saadat et al. Dec 2003 A1
20030236455 Swanson et al. Dec 2003 A1
20030236505 Bonadio et al. Dec 2003 A1
20030236549 Bonadio et al. Dec 2003 A1
20040019254 Belson et al. Jan 2004 A1
20040044270 Barry Mar 2004 A1
20040049251 Knowlton Mar 2004 A1
20040097788 Mourlas et al. May 2004 A1
20040106852 Windheuser et al. Jun 2004 A1
20040176683 Whitin et al. Sep 2004 A1
20040186350 Brenneman et al. Sep 2004 A1
20040193008 Jaffe et al. Sep 2004 A1
20040193009 Jaffe et al. Sep 2004 A1
20040210109 Jaffe et al. Oct 2004 A1
20040220450 Jaffe et al. Nov 2004 A1
20040230096 Stefanchik et al. Nov 2004 A1
20050085693 Belson et al. Apr 2005 A1
20050124855 Jaffe et al. Jun 2005 A1
20050137454 Saadat et al. Jun 2005 A1
20050137455 Ewers et al. Jun 2005 A1
20050137456 Saadat et al. Jun 2005 A1
20050154258 Tartaglia et al. Jul 2005 A1
20050154261 Ohline et al. Jul 2005 A1
20050165276 Belson et al. Jul 2005 A1
20050168571 Lia et al. Aug 2005 A1
20050203339 Butler et al. Sep 2005 A1
20050209506 Butler et al. Sep 2005 A1
20050222497 Belson Oct 2005 A1
20050250990 Le et al. Nov 2005 A1
20060009678 Jaffe et al. Jan 2006 A1
20060015009 Jaffe et al. Jan 2006 A1
20060015010 Jaffe et al. Jan 2006 A1
20060089528 Tartaglia et al. Apr 2006 A1
20060089529 Tartaglia et al. Apr 2006 A1
20060089530 Tartaglia et al. Apr 2006 A1
20060089531 Tartaglia et al. Apr 2006 A1
20060089532 Tartaglia et al. Apr 2006 A1
20060100642 Yang et al. May 2006 A1
20060235457 Belson Oct 2006 A1
20060235458 Belson Oct 2006 A1
20060258912 Belson et al. Nov 2006 A1
20060259029 Utley et al. Nov 2006 A1
20070043259 Jaffe et al. Feb 2007 A1
20070093858 Gambale et al. Apr 2007 A1
20070135803 Belson Jun 2007 A1
20070161291 Swinehart et al. Jul 2007 A1
20070161857 Durant et al. Jul 2007 A1
20070249901 Ohline et al. Oct 2007 A1
20070270650 Eno et al. Nov 2007 A1
20080045794 Belson Feb 2008 A1
20080154288 Belson Jun 2008 A1
20080214893 Tartaglia et al. Sep 2008 A1
20080248215 Sauer et al. Oct 2008 A1
20090099420 Woodley et al. Apr 2009 A1
20090216083 Durant et al. Aug 2009 A1
20100094088 Ohline et al. Apr 2010 A1
20110065993 Belson et al. Mar 2011 A1
20120041262 Belson Feb 2012 A1
20150005576 Belson et al. Jan 2015 A1
20150133858 Julian et al. May 2015 A1
20150320295 Belson et al. Nov 2015 A1
20150359414 Belson Dec 2015 A1
20170020615 Koenig et al. Jan 2017 A1
20190069763 Julian et al. Mar 2019 A1
Foreign Referenced Citations (138)
Number Date Country
2823025 Feb 1986 DE
3707787 Sep 1988 DE
4102211 Aug 1991 DE
19626433 Jan 1998 DE
19729499 Jan 1999 DE
0165718 Dec 1985 EP
382974 Aug 1990 EP
0497781 Jan 1994 EP
0993804 Apr 2000 EP
1101442 May 2001 EP
1681013 Jul 2006 EP
2048086 Mar 1994 ES
2062930 Dec 1994 ES
2732225 Oct 1996 FR
2807960 Oct 2001 FR
2347685 Sep 2000 GB
20000559 Jul 2000 IE
20020170 Mar 2002 IE
4712705 May 1972 JP
61205912 Sep 1986 JP
S63503365 Dec 1986 JP
63136014 Jun 1988 JP
63272322 Nov 1988 JP
1152413 Jun 1989 JP
H01153292 Jun 1989 JP
1229220 Sep 1989 JP
1262372 Oct 1989 JP
2246986 Oct 1990 JP
2296209 Dec 1990 JP
3004830 Jan 1991 JP
3109021 May 1991 JP
3136630 Jun 1991 JP
3139325 Jun 1991 JP
3170125 Jul 1991 JP
4002322 Jan 1992 JP
4054970 Feb 1992 JP
5001999 Jan 1993 JP
5011196 Jan 1993 JP
5111458 May 1993 JP
5177002 Jul 1993 JP
5184531 Jul 1993 JP
5305073 Nov 1993 JP
6007287 Jan 1994 JP
H0670940 Mar 1994 JP
H06142106 May 1994 JP
H06285009 Oct 1994 JP
H06285043 Oct 1994 JP
H06510439 Nov 1994 JP
7088788 Apr 1995 JP
7116104 May 1995 JP
7120684 May 1995 JP
8010336 Jan 1996 JP
8066351 Mar 1996 JP
8322783 Dec 1996 JP
8322786 Dec 1996 JP
9028662 Feb 1997 JP
10014863 Jan 1998 JP
10337274 Dec 1998 JP
11042258 Feb 1999 JP
11048171 Feb 1999 JP
H11509436 Aug 1999 JP
H11313827 Nov 1999 JP
2000279367 Oct 2000 JP
21046318 Feb 2001 JP
21096478 Apr 2001 JP
2001519199 Oct 2001 JP
2001521773 Nov 2001 JP
2002017746 Jan 2002 JP
2002113036 Apr 2002 JP
3322356 Sep 2002 JP
2002264048 Sep 2002 JP
2002531164 Sep 2002 JP
2003504148 Feb 2003 JP
2003525688 Sep 2003 JP
2003528677 Sep 2003 JP
2005507731 Mar 2005 JP
5216986 Jun 2013 JP
871786 Oct 1981 SU
1256955 Sep 1986 SU
1301701 Apr 1987 SU
WO-199219147 Nov 1992 WO
WO-9315648 Aug 1993 WO
WO-199317751 Sep 1993 WO
WO-199419051 Sep 1994 WO
WO-199504556 Feb 1995 WO
WO-9509562 Apr 1995 WO
WO-9605768 Feb 1996 WO
WO-9639963 Dec 1996 WO
WO-199710746 Mar 1997 WO
WO-9725101 Jul 1997 WO
WO-9729701 Aug 1997 WO
WO-9729710 Aug 1997 WO
WO-199811816 Mar 1998 WO
WO-199824017 Jun 1998 WO
WO-9849938 Nov 1998 WO
WO-199916359 Apr 1999 WO
WO-199933392 Jul 1999 WO
WO-199951283 Oct 1999 WO
WO-199959664 Nov 1999 WO
WO-0010456 Mar 2000 WO
WO-200010466 Mar 2000 WO
WO-200027462 May 2000 WO
WO-200054653 Sep 2000 WO
WO-200074565 Dec 2000 WO
WO-200149353 Jul 2001 WO
WO-200158973 Aug 2001 WO
WO-200167964 Sep 2001 WO
WO-200170096 Sep 2001 WO
WO-200170097 Sep 2001 WO
WO-0174235 Oct 2001 WO
WO-200180935 Nov 2001 WO
WO-200224058 Mar 2002 WO
WO-200239909 May 2002 WO
WO-200247549 Jun 2002 WO
WO-200264028 Aug 2002 WO
WO-200268988 Sep 2002 WO
WO-200269841 Sep 2002 WO
WO-200289692 Nov 2002 WO
WO-200296276 Dec 2002 WO
WO-03028547 Apr 2003 WO
WO-03073920 Sep 2003 WO
WO-200373921 Sep 2003 WO
WO-03086498 Oct 2003 WO
WO-03092476 Nov 2003 WO
WO-2004000403 Dec 2003 WO
WO-200406980 Jan 2004 WO
WO-2004019769 Mar 2004 WO
WO-2004049905 Jun 2004 WO
WO-200471284 Aug 2004 WO
WO-200480313 Sep 2004 WO
WO-2004084702 Oct 2004 WO
WO-2005072445 Aug 2005 WO
WO-200584542 Sep 2005 WO
WO-2006136827 Dec 2006 WO
WO-2015175200 Nov 2015 WO
WO-2016043845 Mar 2016 WO
WO-2016183054 Nov 2016 WO
WO-2016205452 Dec 2016 WO
Non-Patent Literature Citations (57)
Entry
“Active endoscope (ELASTOR, shape memory alloy robot),” 9 pages including 3 figures and 4 photographs. Accessed Feb. 21, 2002. Internet: http://mozu.mes.titech.ac.jp/research/medical/endoscope/endoscope.html.
Bar-Cohen, J., “EAP applications, potential, and challenges,” Chapter 21 in Electroactive Polymer (EAP) Actuators as Artificial Muscles, Bar-Cohen, Ed., SPIE Press, 2001; pp. 615-659.
Bar-Cohen, Y., “EAP history, current status, and infrastructure,” Chapter 1 in Electroactive Polymer (EAP) Actuators as Artificial Muscles, Bar-Cohen Ed., SPIE Press, 2001, pp. 3-44.
Bar-Cohen, Y. Ed., Worldwide ElectroActive Polymers (Artificial Muscles) Newsletter, Jun. 2001, vol. 3, issue 1, pp. 1-14.
Bar-Cohen, Y., “Transition of EAP material from novelty to practical applications—are we there yet” Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, pp. 1-6.
Berger, W. L. et al., “Sigmoid Stiffener for Decompression Tube Placement in Colonic Pseudo-Obstruction,” Endoscopy, 2000, vol. 32, Issue 1, pp. 54-57.
Brock, D.L., “Review of artificial muscle based on contractile polymers,” MIT Artificial Intelligence Laboratory, A.I.Memo No. 1330, Nov. 1991, 10 pages. Accessed Jun. 23, 2005. Internet: http://www.ai.mit.edu/projects/muscle/papers/memo1330/memo1330.html.
Cho, S. et al., “Development of micro inchworm robot actuated by electrostrictive polymer actuator,” Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, pp. 466-474.
Office Action issued in corresponding Japanese Application No. P2006-551580, Dispatch Date: Aug. 21, 2012, Dispatch No. 568236.
Duntgen, C., “Walking machines: 0-legged-robots: A compilation by Christian Duntgen,” Aug. 26, 2000, 16 pages.
EP03791924 Supplementary Partial Search Report, dated Feb. 27, 2009, 4 pages.
EP11175098 Extended EP Search Report dated Dec. 1, 2011, 7 pages.
European Search Report for Application No. EP05002014, dated Mar. 31, 2005, 3 pages.
Extended European Search Report for Application No. EP05824444, dated Apr. 13, 2011, 6 pages.
French language U.S. Appl. No. 09/556,673, Christian Francois et al., filed Apr. 21, 2000.
Grecu, E. et al., “Snake-like flexible Micro-robot,” Copernicus project presentation, financed by European Community, Project start May 1, 1995, 6 pages. Accessed Dec. 27, 2001; Internet: http://www.agip.sciences.univ-metz.fr/˜mihalach/Copernicus_project_engl.html.
Hasson, H.M., “Technique of Open Laparoscopy,” (from step 1 to step 9), May 1979, 2424 North Clark Street, Chicago, Illinois 60614, 3 pages.
Ikuta, Koji et al., “Shape memory alloy servo actuator system with electric resistance feedback and application for active endoscope,” Proc. IEEE International Conference on Robotics and Automation, 1988, pp. 427-430, vol. 1, IEEE.
International Preliminary Examination Report for Application No. PCT/US2001/10907, dated Jan. 21, 2003, 3 pages.
International Search Report and Written Opinion for Application No. PCT/US2004/026948, dated Dec. 29, 2005, 4 pages.
International Search Report and Written Opinion for Application No. PCT/US2005/03140, dated May 6, 2008, 6 pages.
International Search Report for Application No. PCT/US2001/10907, dated Aug. 28, 2001, 3 pages.
Ireland Application No. 2000/0225 filed on Mar. 22, 2000, Inventor Declan B., et al.
Jager, E.W.H. et al., “Microfabricating conjugated polymer actuators,” Science, Nov. 24, 2000, vol. 290, pp. 1540-1545.
Japanese application No. 2007-541342 Office Action dated May 17, 2011, 7 pages, including translation.
Japanese Notice of Reasons for Rejection for Patent Application No. JP2014-249104 dated Oct. 30, 2015.
Jeon, J.W. et al., “Electrostrictive polymer actuators and their control systems,” Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, pp. 380-388.
Klaassen, B., “GMD-Snake: Robot snake with a flexible real-time control,” AiS—GMD-Snake, last updated Oct. 17, 2001, 3 pages, accessed Dec. 27, 2001; Internet: http://ais.gmd.de/BAR/snake.html.
Kornbluh, R. et al., “Application of dielectric elastomer EAP actuators,”Chapter 16 in Electroactive Polymer (EAP) Actuators as Artificial Muscles, Yoseph Bar-Cohen, Ed., SPIE Press, 2001, pp. 457-495.
Kubler, C. et al., “Endoscopic robots,” Proceedings of 3rd International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2000), Oct. 11-14, 2000, in Lecture Notes in Computer Science, Springer, vol. 1935, pp. 949-955.
Laptop Magazine, Science & Technology section, Oct. 2002, pp. 98, 100, and 102.
Lee, Thomas S. et al., “A highly redundant robot system for inspection,” Proceedings of Conference on Intelligent Robotics in Field, Factory, Service, and Space (CIRFFSS '94). Mar. 21-24, 1994. vol. 1, pp. 142-148. Houston, Texas.
Lightdale, C.J., “New developments in endoscopy,” American College of Gastroenterology 65th Annual Scientific Meeting, Day 1, Oct. 16, 2000, pp. 1-9.
Madden, J.D.W., Abstract of “Conducting polymer actuators,” Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, 1 page.
Madden, J.D.W. et al., “Polypyrrole actuators: modeling and performance”, Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, pp. 72-83.
Mazzoldi, A., “Smart Catheters,” Internet: http://www.piaggio.ccii.unipi.it/cathe.htm, printed Aug. 27, 2001, 2 pages.
McKernan, J.B. et al., “Laparoscopic general surgery,” Journal of the Medical Association of Georgia, Mar. 1990, vol. 79, Issue 3, pp. 157-159.
Nam, J.D., “Electroactive polymer (EAP) actuators and devices for micro-robot systems,” Nov. 28, 2000, 1 page.
Office Action dated Jul. 30, 2013 for Japanese Application No. 20110200974 filed Sep. 14, 2011.
PCT/US02/29472 International Search Report , dated Mar. 6, 2003, 3 pages.
PCT/US03/06078 International Search Report , dated Aug. 13, 2003, 1 page.
PCT/US03/13600 International Search Report, dated Dec. 12, 2003, 1 page.
PCT/US03/27042 International Search Report, dated Feb. 4, 2004, 2 pages.
PCT/US03/37778 International Search Report, dated Feb. 8, 2005, 1 page.
PCT/US2005/040893 International Search Report and Written Opinion of the International Searching Authority, dated Jun. 23, 2008, 5 pages.
Peirs, J. et al., “Miniature parallel manipulators for integration in a self-propelling endoscope,” IUAP P4/24 IMechS Workshop, Organized by UCL/PRM, Oct. 27, 1999, 2 pages.
Pelrine, R. et al., “Applications of dielectric elastomer actuators,” Smart Structures and Materials 2001: Electroactive Polymer Actuators and Devices, Yoseph Bar-Cohen Ed., Proceedings of SPIE, Mar. 5-8, 2001, vol. 4329, Issue 1, pp. 335-349.
Sansinena, J.M. et al., “Conductive polymers,” Chapter 7 of Electroactive Polymer (EAP) Actuators as Artificial Muscles, Bar-Cohen Ed., SPIE Press, 2001, pp. 193-221.
Slatkin, A.B. et al., “The development of a robotic endoscope,” Proceedings 1995 IEEE/RSJ International Conference on Intelligent Robots and Systems, Aug. 5-9, 1995, vol. 2, pp. 162-171, Pittsburgh, Pennsylvania.
Summons to Attend Oral Proceedings dated Mar. 31, 2016 for European Application No. 05824444.3 filed Nov. 8, 2005, 5 pages.
Supplementary European Search Report for Application No. EP03790076, dated Dec. 28, 2007, 4 pages.
Supplementary European Search Report for Application No. EP04781605, dated Jul. 23, 2010, 3 pages.
Supplementary European Search Report for Application No. EP05712548, dated Jul. 6, 2012, 3 pages.
Supplementary European Search Report of EP Patent Application No. EP03728638, dated Oct. 27, 2005, 2 pages total.
U.S. Appl. No. 12/425,272 Office Action dated Mar. 11, 2011, 7 pages.
Vertut, Jean and Phillipe Coiffet, Robot Technology: Teleoperation and Robotics Evolution and Development, English translation, Prentice-Hall, Inc., Inglewood Cliffs, NJ, USA 1986, vol. 3A, 332 pages.
Zuccaro, G., “Procedural sedation in the GI suite,” A conference co-sponsored by the American Society of Anesthesiologists, 16th Annual Meeting 2001, May 3-6, 2001, pp. 162-171.
Related Publications (1)
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20190365205 A1 Dec 2019 US
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Child 13962264 US
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Child 16443070 US
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