The present invention relates to an apparatus for automatically depositing, preserving and recovering specimens of biological materials in/from a refrigerated store using two distinct static robots.
Nowadays, in specialized laboratories, where tests are carried out on specimens of biological material of patients, the need to prepare refrigerated stores, where the aforesaid specimens can be temporarily stored in a circle along the automated laboratory system, is increasingly felt.
The subject stores must be adapted to ensure adequate preservation of the biological samples contained in test tubes, in anticipation of their future reuse for a subsequent series of tests, possibly even after several days since their collection.
The Applicant has already filed an earlier patent EP 2240787 related to a store which meets the above requirements. Reference shall therefore be made to such a patent for a comprehensive overview of the features of the equipment described therein.
Such a patent, in particular, shows the interfacing of the above store with a portion of a conveyor adapted to the automatic handling of biological material tubes along the entire system, highlighting the possibility of alternatively carrying out the dual task of unloading tubes from the conveyor to the store (for subsequently storing them) and loading tubes from the store to the conveyor (for redirecting the samples, along the conveyor, towards the appropriate testing modules).
Although the above apparatus is able, as mentioned, to carry out both the loading and the unloading operations, the device included therein and adapted to handle the test tubes, both in one direction and in the other, is a single robot able to carry out translational movements in three directions, thus reaching all the points necessary for the execution of the proper tube handling process.
It is understood that the above robot can alternatively handle either a loading or an unloading operation.
US-2005/013734, EP-1477813 and EP-1248170 show apparatuses for handling test tubes to/from a refrigerated store.
Therefore, it is the object of the present invention to provide an apparatus which allows the simultaneous execution of unloading of test tubes from the conveyor to the store and loading of test tubes from the store to the conveyor.
This is in response to the increasingly large number of biological specimens which may need to be handled by an automation system as a whole, and therefore to the need to store or recover from the store with increasing frequency the test tubes containing the specimens themselves.
This and other objects are achieved by an apparatus as described in claim 1.
These and other features of the present invention will become more apparent from the following detailed description of an embodiment thereof, made by way of a non-limiting example in the accompanying drawings, in which:
The two test tube handling devices 3 are each attached to a respective support bracket 6 (
The central control unit 7 (
The two test tube handling devices 3 deal the one (the rightmost one in
The refrigerated store 1 is, as regards its internal structure, similar to the one described in the previous patent EP-2240787, in particular as regards the handling mechanism of the various shelves in which the stored test tube containers 5 are positioned, separated by lanes.
On the front side, store 1 has sliding doors 10 (
Obviously, the sliding door 10 thus opens, through a command sent by the control unit 7, only if a test tube container 5 needs to be moved from the refrigerated store 1 to the container handling device 8 or vice versa; otherwise, all sliding doors 10 remain closed so as to ensure the heat insulation of the refrigerated store 1.
In correspondence with the front wall of the refrigerated store 1, which includes the sliding doors 10, a closed door sensor 14 and a lifted door sensor 15 are secured to a framing (
The container handling device 8 is intended to move test tube containers 5 from inside to outside the refrigerated store 1 and vice versa, and is able to slide parallel to conveyor 4 by means of a carriage 160, to which device 8 is hooked, which moves along a sliding guide 16 (
A sensor 38 is provided in the vicinity of the sliding guide 16 (
Only one sensor 38 is required since the handling along the horizontal axis of the container handling device 8, which allows it to be positioned exactly in correspondence with each lane or each sliding door 10, is managed by an encoder of the electric motor 162 which moves the container handling device 8 along the sliding guide 16.
The container handling device 8 comprises a sliding door opening cylinder consisting of a slider 11 (
The container handling device 8 comprises a front block 81, which faces the sliding doors 10 of the refrigerated store 1. Such a front block 81 comprises a support 17 (
The bottom surface 19 (
Sliding bearings 21 (
The movement of the toothed translation track 18 is generated by an electrical motor 23, whose movement is transmitted by a shaft 24 through a belt 25 to a pulley 26 (
Depending on the various operating steps of the container handling device 8, both the front block 81 and the resting surface 80 thereof can carry out a vertical translation, thus assuming a high or low position, as will be better clarified hereafter. Such vertical translations are ensured by the action of a pneumatic cylinder 27 (and corresponding piston 270) powered by solenoid valves through two flow regulators 28 as regards the front block 81, and by a pneumatic cylinder 31 (and corresponding piston 310) powered by solenoid valves through two flow regulators 32 as regards the resting surface 80 respectively (
Moreover, a test tube container lock cylinder 33 is provided (
As a further confirmation of the presence of a test tube container 5 on the resting surface 80, an antenna 60 is provided inside the resting surface 80 (
Each revolving plate 9 comprises a base 40 and a shaped profile 41 (
Each plate 9 can rotate by 180°, so that each of the two locations can alternatively be the depositing one 42 and the working one 43.
The rotation of plate 9 is made possible by the actuation of a motor 44 and by the motion transmission through a shaft 45 (
The lock of the revolving plate 9 in each of the two positions is ensured by the action of a plate lock cylinder 46 powered by solenoid valves through two flow regulators 47 (
In particular, during the rotation of plate 9, means for detecting the position of plate 9 are activated, consisting of the two cams 48a and 48b and three sensors: a home sensor 49a, a 0° sensor 49b and a 180° sensor 49c (
Moreover, each plate 9 has two test tube container lock cylinders 50 (
Finally, a test tube unloading pipe 52 is also provided (
The operation is as follows: the apparatus of the invention serves to interface the refrigerated store 1 and conveyor 4, enabling a dual operation, i.e. the loading of test tubes 2 from the refrigerated store 1 to conveyor 4 and the unloading of test tubes 2 from conveyor 4 to the refrigerated store 1.
Assuming that tubes 2 travel along conveyor 4 from the right leftwards (as depicted in
In the embodiment shown in
Both in the loading and in the unloading area, at the end of the interfacing by the test tube handling device 3 with each handling device 200, the latter is released (filled with a test tube 2 in the loading area, deprived of a test tube 2 in the unloading area) and returns along the main lane of conveyor 4.
Let's now concentrate on the operation of loading test tubes 2 from store 1 to conveyor 4: it may be necessary if a test tube 2, previously stored in the refrigerated store 1, needs to be recovered along conveyor 4 to be directed to a specific testing module, for example to replicate some tests whose results are deemed abnormal or unsatisfactory, or simply for the purpose of checking and validating the previous results.
The test tube must be picked up from one of the test tube containers 5 stored in store 1. The rack handling mechanism inside store 1 itself allows the rack containing the concerned test tube container 5 to position itself at such a height that the translation of the test tube container 5 is perfectly horizontal. At the same time, the container handling device 8 moves longitudinally, positioning itself in the vicinity of the appropriate lane, ready to accommodate container 5 that is going to be ejected. The sliding of the handling device 8 takes place thanks to the electrical motor 162 (
At this point, the sliding door opening cylinder is activated, the cylinder comprising the slider 11 (
The container handling device 8, before accommodating the test tube container 5, is in a configuration in which both the front block 81 and the resting surface 80 are in the rest position, i.e. “low” (
The actuation of the pneumatic cylinder 29 (according to what is already known from patent EP-2240787) allows the horizontal sliding of the front block 81, which penetrates inside the raised sliding door 10. Afterwards, the raising is controlled to the “high” position of both the front block 81 and of the resting surface 80, to ensure that the subsequent translation of the test tube container 5 is perfectly horizontal. Such a raising takes place by the action of the pneumatic cylinders 27 (for the front block 81) and 31 (for the resting surface 80), respectively, and can be seen in
At this point, the actual displacement of the test tube container 5 from within the refrigerated store 1, i.e. from one of its racks, towards the container handling device 8, may take place; a first step of this displacement is favored by the action of the toothed translation track 18 which draws the test tube container 5 to the right (as shown in
In such a configuration, the container handling device 8, including at this point container 5 suitably detected by antenna 60 as well as locked by hook 35, then travels parallel to conveyor 4 towards the loading revolving plate 9.
When it arrives in the vicinity of the plate itself, the front block 81 of the container handling device 8, precisely because it has previously been lowered, is inserted in a position below base 40 of plate 9 (
Simultaneously, the hollow central region of the depositing location 42 of plate 9 (
The container handling device 8, which is empty at this point and has both the front block 81 and the resting surface 80 in “low” position (thus returning to the rest configuration in
The test tube container 5 just received is meanwhile locked on plate 9 thanks to the exit of block 54 (
After a few moments, the lock imposed by cylinder 46 is deactivated and thus plate 9 rotates by 180°: thereby, the test tube container 5 substantially moves from the depositing location 42 to the outermost working location 43. At this point, subsequent to a new activation of the lock cylinder 46 and thus to a new locking of plate 9, the test tube handling device 3 can go to pick up the desired test tube 2, in any position it is within the test tube container 5 and according to the instructions from central control unit 7. This is because, as said, the test tube handling device 3 (
The test tube 2 picked up by clamp 72 of the test tube handling device 3 is then loaded onto the handling device 200 in stand-by, empty, along the secondary lane of conveyor 4. Alternatively, if the test tube 2 needs not be redirected to a testing module but simply discarded because the life time of the relevant specimen has ended, it is directed into the test tube unloading pipe 52 to end up in the unloading apparatus 53 with multiple racks (
The subsequent rotation of plate 9 returns the test tube container 5 to the depositing location 42, from which the container handling device 8 can pick it up again (after having taken back the configuration in
The situation described has shown the path of a single test tube container 5 on plate 9. Obviously, once a test tube container 5 has been laid on plate 9, and following the rotation of plate 9 itself, container 5 moves from the depositing location 42 to the working location 43, plate 9 can immediately receive in the depositing location 42 now empty a second test tube container 5, again handled by the container handling device 8, and which therefore occupies plate 9 together with the previous one. This situation occurs, for example, when it is necessary to recover two test tubes in a short time, on conveyor 4, which are stored in the refrigerated store 1 in different test tube containers 5, which are located on racks and/or lanes very distant from one another.
The apparatus behaves in a totally similar manner in the case of the unloading operation of test tubes 2 from conveyor 4 to store 1. The discussion is therefore identical, obviously considering the mirror-like arrangement of the unloading plate 9 and of the corresponding test tube handling device 3, as well as the fact that the test tubes 2 in this case follow the opposite path, i.e. they are picked up from the handling device 200 on conveyor 4 and positioned in the test tube container 5 present in the working location 43 of the revolving plate 9.
In the practice, it has been found that the apparatus thus described can achieve the intended objects ensuring, thanks to the use of two distinct test tube handling devices 3 (each coupled to a revolving plate 9), the possibility to carry out, also possibly simultaneously, the operations of loading test tubes 2 from a refrigerated store 1 to a conveyor 4 and vice versa unloading test tubes 2 from conveyor 4 to the refrigerated store 1.
In fact, according to the operational requirements that may occur at any moment, the container handling device 8 is appropriately directed towards one or the other of the two revolving plates 9, therefore moving the test tube containers 5 as appropriate and carrying out the related operations of loading or unloading with a certainly greater frequency compared to known solutions, such as that described in the previous patent EP-2240787 by the Applicant: in fact, both in the case of loading and of unloading, a single three-axis robot is used therein to handle the test tubes, which robot can move from one end to the other of the apparatus, and thus inevitably the handling frequency of the test tubes is lower and times are longer.
The solution of the present invention therefore allows coping with the needs of a quicker storage or release of specimens into/from the refrigerated store 1, in response to the ever increasing operating volumes of a laboratory automation system in terms of number of biological specimens involved.
Several changes and variations may be made to the invention thus conceived, all falling within the scope of the inventive concept.
In the practice, the materials used as well as shapes and sizes, may be any, according to the requirements.
Number | Date | Country | Kind |
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MI2012A2011 | Nov 2012 | IT | national |
Filing Document | Filing Date | Country | Kind |
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PCT/EP2013/074534 | 11/25/2013 | WO | 00 |
Publishing Document | Publishing Date | Country | Kind |
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WO2014/082944 | 6/5/2014 | WO | A |
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