Brader, et. al., "Insulin hexamers: new conformations and applications", Trends In Biochemical Sciences, 16:341-345 (1991). |
Derewenda, et al., "Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer", Nature, 338:594-596 (1989). |
Chothia, et al., "Transmission of conformational change in insulin", Nature, 302: 500-505 (1983). |
Kruger, et. al., "Cooperativity and Intermediate States in the T.fwdarw.R Structural Transformation of Insulin", Biol. Chem. Hoppe-Seyler, 371: 669-673 (1990). |
Bentley, et. al., "Structure of insulin in 4-zinc insulin", Nature, 261: 166-168 (1976). |
Smith et. al., "The Structure of a Rhombohedral R.sub.6 Insulin Hexamer That Binds Phenol", Biopolymers, 32: 441-445 (1992). |
Renscheidt, et. al., "A Solution Equivalent of the 2Zn.fwdarw.4Zn transformation of insulin in the crystal", Eur. J. Biochem, 142: 7-14 (1984). |
Brader, et. al., "Characterization of the R-State Insulin Hexamer and Its Derivatives. The Hexamer Is Stabilized by Heterotropic Ligand Binding Interactions", Biochemistry, 30: 6636-6645 (1991). |
Brange, et. al., "Chemical Stability of Insulin 2. Formation of Higher Molecular Weight Transformation Products During Storage of Pharmaceutical Preparations", Pharmaceutical Research 9: No. 6, 727-734 (1992). |
Brange, et. al., "Chemical stability of insulin 3. Influence of excipients, formulations, and pH" Acta Pharm. Nord., 4: 149-158 (1992). |
Brange, et. al., "Chemical Stability of Insulin. 1. Hydrolytic Degradation During Storage of Pharmaceutical Preparations", Pharmaceutical Research, 9: No. 6, 715-726 (1992). |
Brems, et, al. "Improved insulin stability through amino acid substitution" Protein Engineering, 5 (No. 6), 519-525 (1992). |
Brange, et, al., "Monomeric Insulins and Their Experimental and Clinical Implications", Diabetes Care, 13, No. 9, 923-954 (1990). |
Brange, et. al., "Designing insulin for diabeses therapy by protein engineering" Current Opinion in Structural Biology, 1, 934-940 (1991). |
DiMarchi, et. al., "Synthesis of a fast-acting insulin based on structural homology with insulin-like growth factor I", Peptides: Chemistry and Biology, Proceedings of the Twelfth American Peptide Symposium, 26-28 (1992). |
Goldman, et, al., "Zinc Binding, Circular Dichroism, and Equilibrium Sedimentation Studies on Insulin (Bovine) and Several of Its Derivatives" Biochemistry, 13, No. 22, 4566-4574 (1974). |
Bentley, et. al., "Role of B13 Glu in Insulin Assembly" J. Mol. Biol. 228, 1163-1176 (1992). |
Wollmer, et. al., "Structural Transition in the Metal-Free Hexamer of Protein-Engineered [B13 Gln] Insulin" Biol. Chem. Hoppe-Seyler, 370 1045-1053 (1989). |
Wollmer, et. al., "Phenol-Promoted Structural Transformation of Insulin in Solution" Biol. Chem. Hoppe-Seyler, 368, 903-911 (1987). |
Grant, et. al., "Differences in the Nature of the Interaction of Insulin and Proinsulin with Zinc" Biochem. J., 126, 433-440 (1972). |
Hol, et. al., "The a-helix dipole and the properties of proteins" Nature, 273, 443-446 (1978). |
Shoemaker, et. al., "Tests of the helix dipole model for stabilization of a-helices" Nature, 326 563-567 (1987). |
Presta, et. al., "Helix Signals in Proteins" Science, 240, 1632-1641 (1988). |
Richardson, et. al., "Amino Acid Preferences for Specific Locations at the Ends of a Helices", Science, 240, 1648-1652 (1988). |
Kline, et. al., "Complete Sequence-Specific .sup.1 H NMR Assignments for Human Insulin" Biochemistry, 29, 2906-2913 (1990). |
Goeders, et. al., "Absorption Kinetics of Regular and Isophane (NPH) Insulin In The Normal Dog" Domestic Animal Endocrinology, 4(1): 43-50 (1987). |
Blundell, et al. "Insulin: The Structure In The Crystal And Its Reflection In Chemistry and Biology",, Adv. Protein Chem., 26:279-329 (1972). |
Baker, et al, "The Structure of 2Zn Pig Insulin Crystals At 1.5.ANG. Resolution" Philos. Trans. R. Soc. London, B., 319: 369-456 (1988). |
Merck Index (11th Edition), 789-790 (1989). |
Frank, et al, "The production of Human Proinsulin And Its Transformation To Human Insulin And C-Peptide" Peptides: Synthesis-Structure-Function, Proc. Seventh Am. Pept. Symp. Eds.D. Rich and E. Gross, 729-738 (1981). |
Frank, et al, "Insulin and Proinsulin Conformation in Solution" Diabetes, 21 supp.2: 486-491 (1972). |
Serrano, et al, "Capping and .alpha.-helix stability" Nature 342:296-299 (1989). |
Markowitz, J., et al, "Experimental Surgery of the Pancreas" Experimental Surgery Including Surgical Physiology, 236-252 (1964). |
Kornberg, et al, "Glucose-6-Phosphate Dehydrogenase" Methods In Enzymology 1:323-327 (1955). |
Bathelmai, et al "Enzymatische Bestimmungen der Glucose in Blut, Liquor und Harn" Klin. Wochenschr. 40:585 (1962). |
Monod, et al. "On The Nature of Allosteric Transistions: A Plausible Model" J. Mol. Biol. 12: 88.varies.118 (1965). |
Binder, et al "A Theoretical Model for the Absorption of Soluble Insulin" Artifical Systems For Insulin Delivery edited by P. Brunetti, et al., Raven Press, N.Y. 53-57 1983). |
Stewart, et al Solid Phase Peptide Synthesis Freeman and Co., San Francisco, 1-103 (1969). |
Chance, et al, "The Production of Human Insulin Using Recombinant DNA Technology And A New Chain Combination Procedure" Peptides: Synthesis-Structure-Function Proceedings of the Seventh American Peptide Symposium Edited by D. H. Rich and E. Gross, 721-728 (1981). |