Claims
- 1. A method for detection of diabetes comprising:
- determining the native COUP-TF binding ability in a biological sample by purifying the COUP-TF from the biological sample to be tested;
- adding the COUP oligonucleotide 5'-CCAGGGGTCAGGGGGGGGGTGCTT-3' to the purified COUP-TF; and
- measuring the amount of COUP oligonucleotide/COUP-TF complex formed.
- 2. A cDNA sequence of the formula:
- __________________________________________________________________________5'- 10 20 30 40AGCAGCTGGC GAGATCCGCA GGACGACGTG GCCGGGGGCA50 60 70 80ACCCCGGCGG CCCCAACCCC GCAGCGCAGG CGGCCCGCGG90 100 110 120CGGCGGCGGC GGCGCCGGCG AGCAGCAGCA GCAGGCGGGC130 140 150 160TCGGGCGCGC CGCACACGCC GCAGACCCCG GGCCAGCCCG170 180 190 200GAGCGCCCGC CACCCCCGGC ACGGCGGGGG ACAAGGGCCA210 220 230 240GGGCCCGCCC GGTTCGGGCC AGAGCCAGCA GCACATCGAG250 260 270 280TGCGTGGTGT GCGGGGACAA GTCGAGCGGC AAGCACTACG290 300 310 320GCCAATTCAC CTGCGAGGGC TGCAAAAGTT TCTTCAAGAG330 340 350 360GAGCGTCCGC AGGAACTTAA CTTACACATG CCGTGCCAAC370 380 390 400AGGAACTGTC CCATCGACCA GCACCACCGC AACCAGTGCC410 420 430 440AATACTGCCG CCTCAAGAAG TGCCTCAAAG TGGGCATGAG450 460 470 480GCGGGAAGCG GTTCAGCGAG GAAGAATGCC TCCAACCCAG490 500 510 520CCCAATCCAG GCCAGTACGC ACTCACCAAC GGGGACCCCC530 540 550 560TCAACGGCCA CTGCTACCTG TCCGGCTACA TCTCGCTGCT570 580 590 600GCTGCGCGCC GAGCCCTACC CCACGTCGCG CTACGGCAGC610 620 630 640CAGTGCATGC AGCCCAACAA CATTATGGGC ATCGAGAACA650 660 670 680TCTGCGAGCT GGCCGCGCGC CTGCTCTTCA GCGCCGTCGA690 700 710 720GTGGGCCCGC AACATCCCCT TCTTCCCGGA TCTGCAGATC730 740 750 760ACCGACCAGG TGTCCCTGCT ACGCCTCACC TGGAGCGAGC770 780 790 800TGTTCGTGCT CAACGCGGCC CAGTGCTCTA TGCCGCTGCA810 820 830 840CGTGGCGCCG TTGCTGGCCG CCGCCGGCCT GCATGCCTCG850 860 870 880CCCATGTCTG CCGACCGCGT CGTGGCCTTC ATGGACCACA890 900 910 920TCCGCATCTT CCAGGAGCAG GTGGAGAAGC TCAAGGCGCT930 940 950 960ACACGTCGAC TCAGCCGAGT ACAGCTGCCT CAAAGCCATC970 980 990 1000GTGCTGTTCA CGTCAGACGC CTGTGGCCTG TCGGATGCGG1010 1020 1030 1040CCCACATCGA GAGCCTGCAG GAGAAGTCGC AGTGCGCACT1050 1060 1070 1080GGAGGAGTAC GTGAGGAGCC AGTACCCCAA CCAGCCCAGC1090 1100 1110 1120CGTTTTGGCA AACTGCTGCT GCGACTGCCC TCGCTGCGCA1130 1140 1150 1160CCGTGTCCTC CTCCGTCATC GAGCAGCTCT TCTTCGTCCG1170 1180 1190 1200TTTGGTAGGT AAAACCCCCA TCGAAACTCT CATCCGCGAT1210 1220 1230 1240ATGTTACTGT CTGGGAGCAG CTTCAACTGG CCTTACATGT1250 1260 1270 1280CCATCCAGTG CTCCTAGACC TTGGGCGCTT CCCACCTGCC1290 1300 1310 1320CCGTCCCCCT AGAGACTCAG AGGACCCACC TGGGCCAAGG1330 1340 1350 1360ACTCCAAAGC CGCGGGGACA CCGGGAAGTG CAGCGGGCCA1370 1380 1390 1400GGCAGGCTGG GTGGGAGGGA GGAGGGCCGA GACAGGAGCA1410 1420 1430 1440GCCCACCCAG CAGAAATACA ATCCGAGCTA CAAAGCATGG1450 1460 1470 1480GAAAAAGAGA CTCTTTTAGG ATCAGATCTG TGAGCACGTT1490 1500 1510 1520GGCCAGGAAA AACAAAAAAA CAAAAAAAAA CCG-3'__________________________________________________________________________
- coding for a functional COUP-TF.
Parent Case Info
This application is a continuation of application Ser. No. 07/335,405, filed Apr. 10, 1989, now abandoned.
Non-Patent Literature Citations (4)
Entry |
Sagami et al: "Identification of two Factors Required for transcription of the Ovalbumin Gene" Molecular & Cellular Biology V.6 No. 12 pp. 4259-4267 (Dec. 1986). |
Wang et al (I): "Purification and Characterization of Chicken Ovalbumin Upstream Transcription Factor from He La Cells" Journal of Biological Chemistry V. 262 No. 33 (Nov. 1987) pp. 16080-16086. |
Wang et al (II): "Studies of Coup Transcription Factor From HeLa Cells: Purification and Partial Characterization" Progress in Clinical Biological Research V 284 pp. 37-51 (1988). |
Dame et al: "Structure of the Gene Encoding the Immuno-dominant Surface Anitgen on the Sporofoite of the Human Malaria Parasite Plasmodium falciparum" Science V 225, pp. 593-599 (Aug. 10, 1984). |
Continuations (1)
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Number |
Date |
Country |
Parent |
335405 |
Apr 1989 |
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