Claims
- 1. A method for predicting the likelihood that an individual will have a neuropsychiatric disorder, comprising the steps of:
a) obtaining a DNA sample from an individual to be assessed; and b) determining the nucleotide present at the polymorphic position in SEQ ID NO: 1, wherein the presence of an “C” at this position indicates that the individual has an increased likelihood of having a neuropsychiatric disorder than an individual having a “T” at that position.
- 2. A method according to claim 1, wherein the neuropsychiatric disorder is schizophrenia.
- 3. A method according to claim 1, wherein the individual is an individual at risk for development of schizophrenia.
- 4. A method for predicting the likelihood that an individual will have a neuropsychiatric disorder, comprising the steps of:
a) obtaining a DNA sample from an individual to be assessed; and b) determining the nucleotide present at the polymorphic position in SEQ ID NO: 2, wherein the presence of an “A” at this position indicates that the individual has an increased likelihood of having a neuropsychiatric disorder than an individual having a “G” at that position.
- 5. A method according to claim 4, wherein the neuropsychiatric disorder is schizophrenia.
- 6. A method according to claim 4, wherein the individual is an individual at risk for development of schizophrenia.
- 7. A method for predicting the likelihood that an individual will have reduced symptomology associated with a neuropsychiatric disorder, comprising the steps of:
a) obtaining a DNA sample from an individual to be assessed; and b) determining the nucleotide present at the polymorphic position in SEQ ID NO: 1, wherein the presence of an “T” at this position indicates that the individual has a greater likelihood of having reduced symptomology associated with a neuropsychiatric disorder than an individual having a “C” at that position.
- 8. A method according to claim 7, wherein the neuropsychiatric disorder is schizophrenia.
- 9. A method for predicting the likelihood that an individual will have reduced symptomology associated with a neuropsychiatric disorder, comprising the steps of:
a) obtaining a DNA sample from an individual to be assessed; and b) determining the nucleotide present at the polymorphic position in SEQ ID NO: 2, wherein the presence of an “G” at this position indicates that the individual has a greater likelihood of having reduced symptomology associated with a neuropsychiatric disorder than an individual having a “A” at that position.
- 10. A method according to claim 10, wherein the neuropsychiatric disorder is schizophrenia.
- 11. A method of diagnosing or aiding in the diagnosis of a neuropsychiatric disorder in an individual comprising
a) obtaining a nucleic acid sample from the individual; and b) determining the nucleotide present at one or more of the polymorphic positions in SEQ ID NO: 1 and in SEQ ID NO: 2, wherein presence of one or more of a C at the polymorphic position in SEQ ID NO: 1, or an A at the polymorphic position in SEQ ID NO: 2 is indicative of increased likelihood of a neuropsychiatric disorder in the individual as compared with an individual having one or more of a T at the polymorphic position in SEQ ID NO: 1, or a G at the polymorphic position in SEQ ID NO: 2.
- 12. The method of claim 11, wherein the nucleotides present at the polymorphic positions in both SEQ ID NO: 1 and SEQ ID NO: 2 are determined.
- 13. The method of claim 11, wherein the neuropsychiatric disorder is schizophrenia.
- 14. A method of diagnosing or aiding in the diagnosis of a neuropsychiatric disorder in an individual comprising
a) obtaining a nucleic acid sample from the individual; and b) determining the nucleotide present at one or more of the polymorphic positions in SEQ ID NO: 1 and in SEQ ID NO: 2, wherein presence of one or more of a T at the polymorphic position in SEQ ID NO: 1, or a G at the polymorphic position in SEQ ID NO: 2 is indicative of decreased likelihood of a neuropsychiatric disorder in the individual as compared with an individual having one or more of a C at the polymorphic position in SEQ ID NO: 1, or an A at the polymorphic position in SEQ ID NO: 2.
- 15. The method of claim 14, wherein the nucleotides present at the polymorphic positions in both SEQ ID NO: 1 and SEQ ID NO: 1 are determined.
- 16. The method of claim 14, wherein the neuropsychiatric disorder is schizophrenia.
- 17. A method for predicting the likelihood that an individual will have a neuropsychiatric disorder, comprising the steps of:
a) obtaining a DNA sample from an individual to be assessed; and b) determining the nucleotide present at one or more of the polymorphic positions in SEQ ID NO: 1 and in SEQ ID NO: 2, wherein presence of one or more of a C at the polymorphic position in SEQ ID NO: 1, or an A at the polymorphic position in SEQ ID NO: 2 is indicative of increased likelihood of a neuropsychiatric disorder in the individual as compared with an individual having one or more of a T at the polymorphic position in SEQ ID NO: 1, or a G at the polymorphic position in SEQ ID NO: 2.
- 18. The method according to claim 17, wherein the nucleotides present at the polymorphic positions in both SEQ ID NO: 1 and SEQ ID NO: 2 are determined.
- 19. The method according to claim 17, wherein the individual is an individual at risk for development of a neuropsychiatric disorder.
- 20. The method according to claim 17, wherein the neuropsychiatric disorder is schizophrenia.
- 21. A method for predicting the likelihood that an individual will have reduced symptomology associated with a neuropsychiatric disorder, comprising the steps of:
a) obtaining a DNA sample from an individual to be assessed; and b) determining the nucleotide present at one or more of the polymorphic positions in SEQ ID NO: 1 and in SEQ ID NO: 2, wherein presence of one or more of a T at the polymorphic position in SEQ ID NO: 1, or a G at the polymorphic position in SEQ ID NO: 2 is indicative of decreased likelihood of a neuropsychiatric disorder in the individual as compared with an individual having one or more of a C at the polymorphic position in SEQ ID NO: 1, or an A at the polymorphic position in SEQ ID NO: 2.
- 22. The method according to claim 21, wherein the nucleotides present at the polymorphic positions in both SEQ ID NO: 1 and SEQ ID NO: 2 are determined.
- 23. The method according to claim 21, wherein the individual is an individual at risk for development of a neuropsychiatric disorder.
- 24. The method according to claim 21, wherein the neuropsychiatric disorder is schizophrenia.
- 25. An oligonucleotide microarray having immobilized thereon a plurality of probes, wherein at least one of said probes is specific for the variant form of the single nucleotide polymorphism in SEQ ID NO: 1.
- 26. An oligonucleotide microarray having immobilized thereon a plurality of probes, wherein at least one of said probes is specific for the reference form of the single nucleotide polymorphism in SEQ ID NO: 1.
- 27. An oligonucleotide microarray having immobilized thereon a plurality of probes, wherein at least one of said probes is specific for the variant form of the single nucleotide polymorphism in SEQ ID NO: 2.
- 28. An oligonucleotide microarray having immobilized thereon a plurality of probes, wherein at least one of said probes is specific for the reference form of the single nucleotide polymorphism in SEQ ID NO: 2.
- 29. An oligonucleotide microarray having immobilized thereon a plurality of probes, wherein at least one of said probes is specific for the variant form of the single nucleotide polymorphism in SEQ ID NO: 1 and wherein at least one of said probes is specific for the variant form of the single nucleotide polymorphism in SEQ ID NO: 2.
- 30. An oligonucleotide microarray having immobilized thereon a plurality of probes, wherein at least one of said probes is specific for the reference form of the single nucleotide polymorphism in SEQ ID NO: 1 wherein at least one of said probes is specific for the reference form of the single nucleotide polymorphism in SEQ ID NO: 2.
RELATED APPLICATIONS
[0001] This application claims priority to U.S. Provisional Application No. 60/265,910 filed Feb. 2, 2001, the contents of which are incorporated by reference in their entirety.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60265910 |
Feb 2001 |
US |