Automatic X-ray detection for intra-oral dental x-ray imaging apparatus

Information

  • Patent Grant
  • 6775351
  • Patent Number
    6,775,351
  • Date Filed
    Thursday, January 4, 2001
    23 years ago
  • Date Issued
    Tuesday, August 10, 2004
    19 years ago
Abstract
An apparatus and method used in intra-oral dental x-ray imaging equipment provides automatic detection of the x-ray emission in order to obtain timely transition to the image integration and acquisition phase with high level of rejection of false triggering induced by blemish defects of the image sensor or by variations of the ambient and temperature conditions. A solid state imager, such as a CCD image sensor, is continually clocked during the standby phase prior to irradiation from an X-ray source, so providing on same time an output signal proportional to the accumulated dark current and the continuous removal of the same. A control unit analyses the output signal of the imager, detects the variation caused by the start of the x-ray emission using appropriate threshold levels, and automatically triggers the imager to the image integration and acquisition phases. Based on memorised maps of the imager blemish defects, and continually monitored variations of the imager output signal, the control unit will reject false triggering due to imager defects or variations of the ambient and temperature conditions.
Description




BACKGROUND OF THE INVENTION




CCD and other types of solid state imagers have got widespread use in dental and medical radiology for their ability to provide in real time x-ray images of high diagnostic value, with reduced levels of the X-ray dose imparted to the patient versus the conventional radiographic film.




In the most typical arrangement the imager is in a wait state, and requires to be triggered into an integration state as soon as the irradiation starts, where the imager clocking is suspended and the x-ray conversion charge is accumulated.




It is one desirable feature that the triggering to the integration state occurs in an automatic way, without need of connections to the x-ray generator, using as low as possible x-ray dose threshold to minimise useless x-ray dosage to the patient.




In case that such automatic triggering is adopted, adequate provision is also desirable against occurrence of false triggering, as it may be caused by variations in the image sensor output signal due to abnormal imager defects and/or variations of the ambient and temperature conditions.




For the intrinsic characteristics of the imager, usually a remarkable dark current is spontaneously generated, which is having a negative impact on the noise performance of the diagnostic image.




It is another desirable feature that appropriate technique is used to remove the generated dark current and its effects on the acquired image. It is also desirable that the method used to remove the dark current will have a minimised impact on the power consumption of the imaging system, to favour those applications where the imaging system is to be self powered from the communication port of the computer station without need of additional external power supply and cabling, and easy portability of the imaging system between different computer stations shall be provided.




Prior art automatic x-ray detection apparatus have been based on an electrical connection with the x-ray generator, where a control signal is generated synchronised with the start of the exposure, to be used by the imager to automatically switch into integration mode.




Such arrangement is clearly disadvantageous for the need of having an electrical connection with the x-ray generator.




In other prior art arrangements one or more x-ray detectors, such as photo diodes, are located close to the imaging area and are used to provide detection of the x-ray emission and switching of the imager to integration mode, by a suitable control signal sent to the control electronics.




Such arrangement is inherently more expensive, although characterised by a prompt reaction time, and does not provide the collateral advantage of removing the accumulated dark current as provided by the continuous clocking and readout method.




In other prior art arrangements the imager is continuously clocked and readout during standby mode prior to irradiation, the video output signal produced by the imager is compared with a threshold level by using a comparator circuit, if the threshold level is exceeded the imager is automatically switched into integration mode. As a variation of this arrangement the threshold level may be continually adjusted to account for variations of the temperature and ambient conditions.




This arrangement is disadvantageous because it requires an external analogue circuit for the comparison and does not allow for sophisticated processing of the video output in order to prevent false triggering caused by abnormal imager defects.




SUMMARY OF THE INVENTION




The object of the invention is an automatic x-ray detection apparatus and method for x-ray digital imagers for dental and medical application, capable of producing automatic triggering of the imager to the integration mode with immediate reaction to the start of the x-ray emission, and including provision against occurrence of false triggering caused by variations in the image sensor output signal due to abnormal imager defects and/or variations of the ambient and temperature conditions.




The method adopted will ensure at the same time effective removal of the dark current spontaneously generated in the imager, with minimised impact on the power consumption of the imaging system, while the apparatus will perform its function without need of electrical connections to the x-ray generator and will use the processing power of the existing microcontroller, without need of additional comparator circuitry.




The invention is particularly advantageous for the dental and medical x-ray diagnosis, where the outlined features find immediate application, but it could also be advantageously employed in other non medical applications having similar requirements.




Herefollowing is a description in greater detail of the invention, based on the exemplary embodiment illustrated in the attached drawings.











DESCRIPTION OF DRAWINGS AND TABLES





FIG. 1

is a diagram showing an exemplary system dedicated to dental application





FIG. 2

is a flow chart illustrating the main apparatus functions and method;











DETAILED DESCRIPTION




The system illustrated in

FIG. 1

is a typical x-ray diagnostic system dedicated to dental intra-oral radiography with digital image acquisition.




The x-ray source


1


is aligned with the image receptor


2


(the x-ray imager) by means of a suitable alignment device. The imager is located in the patient mouth, behind the object (tooth) to be imaged. It is connected to the control unit


3


, providing imager control and image acquisition and transfer to the main processor


4


(i.e. the Personal Computer), where the diagnostic image display, processing and archive is performed.




The x-ray imager is a solid state device including a matrix of radiation sensitive pixels.




Solid state imagers, such as CCD devices, are in general exhibiting spontaneous generation of dark current, which is in turn generating a noise signal increasing, by know relations, with the temperature and with the time.




As this noise signal may significantly use the signal range of the device, it is imperative that adequate provision is taken to remove its contribution from the useful image signal.




In the proposed arrangement a continuous read out of the imager is performed during the wait time before irradiation, and the output signal is converted in digital form and analysed by the control unit, with the multiple purpose of (1) detecting variations of the output signal versus a threshold reference which can be correlated with the start of the irradiation, (2) rejecting variations of the output signal which are caused by abnormal blemish defects of the imager, (3) providing simulation of the imager temperature and accordingly correction of the threshold reference based on the actual device temperature.




The same read out process will ensure the cyclic removal of the dark current during the wait time, so minimising its influence on the latent image which will build into the imager during the integration mode.




The read out process during wait time will also adopt adequate strategy to minimise the power consumption. This will result particularly favourable in those applications where the power consumption shall be reduced to allow easy portability of the imaging system between different computer stations and self powering from the communication port of the same computer station, without need of additional external power supply and cabling.




Of course dark current will spontaneously generate during the integration and acquisition phases as well. Know methods are available to reduce this influence either by techniques to minimise the dark current generation into the solid state device, or by providing a subtraction of a dummy image build up without irradiation using similar integration time as used during the irradiation.




The automatic x-ray detection apparatus incorporates several functions, which are illustrated in FIG.


2


and are described below:




IBM (Initial Blemishes Mapping).




This functional unit performs an initial read out of the whole imager pixel matrix, with the purpose of creating a map of the pixels showing blemish defect.




In a first arrangement, the output signal from each imager matrix pixel is analysed and the pixels having signal in excess of a predefined threshold reference quantity are individually recorded.




In another preferred arrangement the imager matrix may be divided into sections and within each section the pixels may be grouped and added together (so creating a super-pixel), to collect a significant signal and to reproduce the same readout policy adopted during the standby readout (see the following SRC function). The output signal from each super-pixel is analysed and, for each imager section, the super-pixels having signal in excess of a predefined threshold reference quantity are individually recorded.




It has to be noticed that, by performing such initial readout at each power on of the control unit, it is ensured the immediate recording of any new pixel blemishes which may generate into the imager device.




(a) SRC (Standby Readout Cycle).




This functional unit performs a cyclic read out of the imager matrix during the standby phase, producing the output O(i,j) at each cycle (i), where j is index of the output element. The read out will have the consequential effect of removing at each cycle the dark current accumulated in all pixels of the matrix.




In a first arrangement, the whole imager matrix is read out pixel by pixel, and an output signal is generated referred to each individual pixel.




In a second preferred arrangement the imager matrix may be divided into sections and within each section the pixels may be grouped and added together (so creating a super-pixel), with the purpose of collecting a significant signal for the comparison. In this arrangement the output signal will be referred to each super-pixel.




As a variant of the second arrangement, it may be particularly advantageous in applications where the minimisation of the power consumption is required, such as for example CCD imagers with control electronics self powered from the USB port of a Personal Computer, to adopt a low power read out strategy, by using the reduction of the amount of the high frequency pixel shifts in the readout register, which typically provide a major contribution to the on chip power consumption. It can be achieved for example by shifting first all the lines of a section into the readout register, and then shifting all the pixels of the readout register to the output circuit. The amount of low frequency line shifts should therefore be maximised, taking also in consideration eventual limitations associated with the full-well capacity of the readout register elements.




(b) XDU (X-ray Detection Unit).




This functional unit processes the output generated by the SRC function, in order to identify the start of the irradiation and consequently generate a control signal to trigger the transition of the imager to integration mode.




In the preferred arrangement a multiple threshold will be used, with the purpose of ensuring at the same time fast response to the start of irradiation and high level of filtration of the noise components (thermal noise, dark current).




The output signal O(i,j) generated by the SRC function at the cycle (i) will be compared with a first threshold (TH1), to identify the pixels, or super-pixels, providing x-ray stimulated output signal. The number of such pixels will then be counted, and will be compared with a second threshold (TH2). In case that such number will exceed the second Threshold Reference (TH2), the start of irradiation will be identified and a control signal will be generated to trigger the transition of the imager to integration mode.




Output values which exceed the TH1 level, but which also correspond to pixels or super-pixels previously identified by the IBM function as blemishing, will be rejected.




In an alternative arrangement the start of irradiation may be identified by the simple detection of the first output signal exceeding the first threshold TH1. This arrangement is characterised by fast response but lower capacity of filtration of the noise components.




Another alternative arrangement may use a derivative approach, by comparing with a TH1 threshold the variation of the output signal between adjacent pixels or super-pixels. This arrangement is also characterised by fast response, but very low filtration of the noise components.




Another alternative arrangement may use an integrative approach, by integrating the output signal and comparing the integrated value with a threshold TH1. This arrangement is characterised by a slow response, but a high level of filtration of the noise components.




(c) TSU (Temperature Simulation Unit).




This functional unit performs a simulation of the imager temperature and accordingly a correction of the first Threshold Reference (TH1) value, to account for variations of the dark current related pixel (or super-pixel) signal in consequence of variations of the device temperature.




Generally the simulation T(i) of the imager temperature at the cycle (i) will be a function f[O(i,j)] of the output O(i,j) generated by the SRC function at the cycle (i). In the preferred arrangement the function f[O(i,j)] will be the average over a consistent number of pixels, or super-pixels, which were not identified as blemishing by the IBM function.




The calculation of the Threshold Reference 1 Corrected TH1c(i) will be generally obtained as a function f[TH1c(i−1), T(i)] of the simulated temperature T(i) at the cycle (i) and of the Threshold Reference 1 Corrected TH1c(i−1) at the cycle (i−1).




In the preferred arrangement the Threshold Reference 1 Corrected TH1c(i) at the cycle (i) will be obtained by adding to the Threshold Reference 1 Corrected (TH1c) at the cycle (i−1) a term derived by the simulated temperature T(i) multiplied by a constant scaling factor(0<k<1), according to the relation








TH


1


c


(


i


)=(1−


k


)*


TH


1


c


(


i−


1)+


k*T


(


i


).






The preferred arrangement will provide smoothed response with higher rejection of noise terms.




Based on the functional units above, the method of this invention will be based on the following steps (refer also to the flow chart in illustration 2):




1) After switch on of the apparatus, an initial readout of the imager matrix is performed, by the IBM function, to generate a map of the pixels (or super-pixels) showing blemish defect.




2) During the standby phase, a cyclic read out of the imager matrix is performed, using the SRC function. At each cycle (i) the functional unit will generate the output O(i,j), where (j) is the index of the element. The read out may be executed either by pixel or by super-pixel, eventually sub-dividing the imager area in sections. The read out will have the consequential effect of removing at each cycle the dark current accumulated in all pixels of the matrix.




3) The output of the SRC function is analysed by the TSU function, in order to provide a simulated value of the device temperature.




The simulated temperature value T(i) at the cycle (i) is used to calculate the Threshold Reference 1 Corrected TH1c(i) for the XDU function.




4) The output of the SRC function is also used by the XDU function, to detect the start of irradiation.




In the preferred arrangement the output signal will be compared with a first threshold 1 (TH1), to identify the pixels, or super-pixels, providing x-ray stimulated output signal. The number of such pixels will then be counted, and will be compared with a second threshold (TH2). In case that such number will exceed the second Threshold Reference (TH2), the start of irradiation will be identified and a control signal will be generated to trigger the transition of the imager to integration mode.



Claims
  • 1. In x-ray imaging systems for digital radiography, an apparatus for the automatic detection of the start of irradiation comprising:1.1. an x-ray source, not connected with the imaging system, controlling the irradiation upon command from the operator; 1.2. an x-ray imager, aligned with the x-ray source, and electrically coupled to a suitable control unit; 1.3. a control unit, controlling the operating modes of the x-ray imager and providing the following functions: (a) IBM (Initial Blemishes Mapping) functional unit performing the initial read out of the whole imager pixel matrix, and creating a map of the pixels or super-pixels showing blemish defect; (b) SRC (Standby Readout Cycle) functional unit performing a cyclic read out of the imager matrix during the standby phase; the read out has the consequential effects of removing at each cycle the dark current accumulated in all pixels of the matrix, and providing an output signal related to pixels, or super-pixels, for the later processing by the TSU and XDU functions; (c) XDU (X-ray Detection Unit) functional unit processing the output generated by the SRC function, comparing it with a first threshold 1 (TH1), to identify the pixels, or super-pixels, providing x-ray stimulated output signal, counting the number of such pixels, and comparing the count with a second threshold (TH2); in case that the count exceeds the second Threshold Reference (TH2), the start of irradiation is identified and a control signal is generated to trigger the transition of the imager to integration mode; (d) TSU (Temperature Simulation Unit) functional unit performing a simulation of the imager temperature and accordingly a correction of the first Threshold Reference (TH1) value, to account for variations of the dark current related pixel (or super-pixel) signal in consequence of variations of the device temperature; and the automatic detection of the start of the irradiation, including the steps of:A) performing, after switch on of the apparatus, an initial readout of the imager matrix by the IBM function, to generate a map of the pixels (or super-pixels) showing blemish defect; B) performing, during the standby phase, a cyclic read out of the imager matrix using the SRC functional unit; at each cycle (i) the functional unit will generate the output O(i,j), where (j) is the index of the element; the read out may be executed either by pixel or by super-pixel, eventually sub-dividing the imager area in sections; the read out will have the consequential effect of removing at each cycle the dark current accumulated in all pixels of the matrix; C) processing the output of the SRC function by the TSU function, in order to provide a simulated value of the device temperature and a correction of the first Threshold Reference (TH1); in the general arrangement the simulation T(i) of the imager temperature at the cycle (i) will be a function f[O(i,j)] of the output O(i,j) generated by the SRC functional unit at the cycle (i), while the Threshold Reference 1 Corrected TH1c(i) at the cycle (i) will be a function f[TH1c(i−1), T(i)] of the Threshold Reference 1 Corrected TH1c(i−1) at the cycle (i−1), and of the simulated temperature T(i) at the cycle (i); D) processing the output of the SRC function by the XDU function, to detect the start of irradiation; the output O(i,j) produced by the SRC functional unit is compared with a first threshold 1 (TH1), to identify the pixels, or super-pixels, providing x-ray stimulated output signal; the number of such pixels, or super-pixels, will then be counted, and will be compared with a second threshold (TH2); in case that the count will exceed the second Threshold Reference (TH2), the start of irradiation will be identified and a control signal will be generated to trigger the transition of the imager to integration mode.
  • 2. The apparatus as set forth in claim 1 wherein the Imager matrix initial readout is performed pixel by pixel, and the IBM function analyses the output signal from each imager matrix pixel and records individually the pixels having signal in excess of a predefined threshold reference quantity.
  • 3. The apparatus as set forth in claim 1 wherein the imager matrix initial readout is performed having divided the matrix in sections and within each section having binned the pixels together (so creating a super-pixel), to reproduce the same readout policy adopted during the standby readout by the SRC function; the output signal from each super-pixel is analysed and, for each imager section, the super-pixels having signal in excess of a predefined threshold reference quantity are individually recorded.
  • 4. The apparatus as set forth in claim 1 wherein the imager matrix read out performed by the SRC function during standby period is done having divided the matrix in sections and within each section having binned the pixels together (so creating a super-pixel), so generating an output signal referred to each super-pixel.
  • 5. The apparatus as set forth in claim 1 wherein the imager matrix read out performed by the SRC function during standby period is done having divided the matrix in sections and within each section having binned the pixels together (so creating a super-pixel), using a preferred variant where all the lines of the section are first clocked into the readout register and then the readout register is clocked out, so generating an output signal referred to each super-pixel consisting of a column of the section; the variant will be particularly advantageous in applications where the reduction of the power consumption is required, by minimisation of the higher frequency readout register clocks, as applicable, but not limited to, CCD imagers with control electronics self powered from the USB port of a Personal Computer.
  • 6. The apparatus as set forth in claim 1 wherein the simulation T(i) of the imager temperature at the cycle (i) performed by the TSU functional unit is obtained by processing the output O(i,j) generated by the SRC function at the cycle (i) and calculating the function f[O(i,j)] as the average over a consistent number of pixels, or super-pixels, which were not identified as blemishing by the IBM functional unit.
  • 7. The apparatus as set forth in claim 1 wherein the calculation of the Threshold Reference 1 Corrected (TH1c) at the cycle (i) performed by the TSU functional unit is obtained by adding to the Threshold Reference 1 Corrected (TH1c) at the cycle (i−1) a term derived by the simulated temperature T(i) multiplied by a constant scaling factor (k), according to the relationTH1c(i)=(1−k)*TH1c(i−1)+k*T(i).
  • 8. The apparatus as set forth in claim 1 wherein the XDU functional unit replaces at each cycle (i) the first Threshold Reference (TH1) by the Threshold Reference 1 corrected TH1c(i), as calculated by the TSU functional unit at the cycle (i).
  • 9. The apparatus as set forth in claim 1 wherein the XDU functional unit processes the output Q(i,j) generated by the SRC function at the cycle (i) and rejects output values which are exceeding the TH1 level (or alternatively the TH1c level) but which are also corresponding to pixels or super-pixels previously identified by the IBM function as blemishing.
  • 10. The apparatus as set forth in claim 1 wherein the XDU functional unit processes the output O(i,j) generated by the SRC function at the cycle (i) and identifies the start of irradiation by the simple detection of the first output signal exceeding the first threshold TH1 level (or alternatively the TH1c level).
  • 11. The apparatus as set forth in claim 1 wherein a derivative approach is used by the XDU functional unit to identify the start of irradiation, by processing the output O(i,j) generated by the SRC function at the cycle (i) and comparing with a single Threshold Reference (TH1 or alternatively TH1c) the variation of the output signal between adjacent pixels or super-pixels, and detecting the first instance where the variation exceeds the threshold.
  • 12. The apparatus as set forth in claim 1 wherein an integrative approach is used by the XDU functional unit to identify the start of irradiation, by processing the output O(i,j) generated by the SRC function at the cycle (i), integrating the output signal, comparing the integrated value with a single Threshold Reference (THR), and detecting the first instance where the integrated value exceeds the THR.
Parent Case Info

This application claims the benefit of provisional application No. 60/179,639 filed Feb. 2, 2000.

US Referenced Citations (103)
Number Name Date Kind
3894235 Franke Jul 1975 A
3911273 Franke Oct 1975 A
3974385 Grim Aug 1976 A
3987281 Hodes Oct 1976 A
3991314 Schmitman et al. Nov 1976 A
4021672 Franke May 1977 A
4061920 Mollendorf et al. Dec 1977 A
4070578 Timothy et al. Jan 1978 A
4097741 Pfeiler et al. Jun 1978 A
4104531 Weiss Aug 1978 A
4158138 Hellstrom Jun 1979 A
4160906 Daniels et al. Jul 1979 A
4160997 Schwartz Jul 1979 A
4188537 Franke Feb 1980 A
4247780 Webber et al. Jan 1981 A
4259582 Albert Mar 1981 A
4352987 Hayashi et al. Oct 1982 A
4454606 Relihan Jun 1984 A
4475224 Grassme Oct 1984 A
4486896 Richter et al. Dec 1984 A
4495632 Nakano Jan 1985 A
4501010 Grassme Feb 1985 A
4589121 Makino May 1986 A
4641331 Makino et al. Feb 1987 A
4675888 Gastrin Jun 1987 A
4741007 Virta et al. Apr 1988 A
4783793 Virta et al. Nov 1988 A
4797905 Ochmann Jan 1989 A
4811372 Doebert et al. Mar 1989 A
4813060 Heubeck et al. Mar 1989 A
4815115 Nieminen et al. Mar 1989 A
4823369 Guenther et al. Apr 1989 A
4847881 Heubeck Jul 1989 A
4856038 Guenther et al. Aug 1989 A
4878234 Pfeiffer et al. Oct 1989 A
4905265 Cox et al. Feb 1990 A
4930146 Flakas et al. May 1990 A
4980905 Meccariello Dec 1990 A
4985907 Moteni Jan 1991 A
4995062 Schulze-Ganzlin et al. Feb 1991 A
5005195 Lanza et al. Apr 1991 A
5018177 McDavid et al. May 1991 A
5043582 Cox et al. Aug 1991 A
5090040 Lanza et al. Feb 1992 A
5090047 Angotti et al. Feb 1992 A
5093852 Nishikawa et al. Mar 1992 A
5195114 Sairenji et al. Mar 1993 A
5214686 Webber May 1993 A
5267296 Albert Nov 1993 A
5293312 Waggener Mar 1994 A
5386448 Tammisalo et al. Jan 1995 A
D355964 Nelvig Feb 1995 S
5425065 Jarvenin Jun 1995 A
5434418 Schick Jul 1995 A
5454022 Lee et al. Sep 1995 A
5473660 Bastiaens et al. Dec 1995 A
5490197 Albert et al. Feb 1996 A
5511106 Doebert et al. Apr 1996 A
5513252 Blaschka et al. Apr 1996 A
5519437 Nelvig May 1996 A
5519751 Yamamoto et al. May 1996 A
5541974 Sklebitz Jul 1996 A
5579366 Docbert et al. Nov 1996 A
5583905 Nishiki et al. Dec 1996 A
5600699 Suzuki et al. Feb 1997 A
5602896 Diepstraten Feb 1997 A
5608455 Oda Mar 1997 A
5617462 Spratt Apr 1997 A
5625662 Toth et al. Apr 1997 A
5640018 Suzuki et al. Jun 1997 A
5663998 Suzuki et al. Sep 1997 A
5664001 Tachibana et al. Sep 1997 A
5668375 Petrick et al. Sep 1997 A
5677940 Suzuki et al. Oct 1997 A
5694448 Morcom Dec 1997 A
5742659 Atac et al. Apr 1998 A
5744806 Frojd Apr 1998 A
5751783 Granfors et al. May 1998 A
5757011 Whitebook et al. May 1998 A
5773832 Sayed et al. Jun 1998 A
5784429 Arai Jul 1998 A
5796430 Katoh et al. Aug 1998 A
5812191 Orava et al. Sep 1998 A
5828720 Syrjanen Oct 1998 A
5828721 Schulze-Ganzlin et al. Oct 1998 A
5864146 Karellas Jan 1999 A
5892227 Schieber et al. Apr 1999 A
5912942 Schick et al. Jun 1999 A
5923722 Schulz Jul 1999 A
5930330 Wolfe et al. Jul 1999 A
5933471 Kalvin Aug 1999 A
5969360 Lee Oct 1999 A
5974166 Ino et al. Oct 1999 A
6002742 Nelvig Dec 1999 A
6035013 Orava et al. Mar 2000 A
6047042 Khutoryansky et al. Apr 2000 A
6055292 Zeller et al. Apr 2000 A
6069935 Schick et al. May 2000 A
6081739 Lemchen Jun 2000 A
6093019 Morandi et al. Jul 2000 A
6134298 Schick et al. Oct 2000 A
6149300 Greenway et al. Nov 2000 A
6169781 Doebert et al. Jan 2001 B1
Foreign Referenced Citations (39)
Number Date Country
1259711 Sep 1989 CA
42 38 268 May 1994 DE
44 33 545 Mar 1996 DE
19823958 May 1998 DE
196 48 052 Jun 1998 DE
197 54 463 Jun 1998 DE
196 48 076 Feb 1999 DE
197 31 927 Feb 1999 DE
197 34 717 Feb 1999 DE
0 229 497 Jul 1987 EP
0 234 603 Sep 1987 EP
0 373 717 Jun 1990 EP
0 408 167 Jan 1991 EP
0 574 368 Dec 1993 EP
0 632 994 Jan 1995 EP
0 632 995 Jan 1995 EP
0 634 671 Jan 1995 EP
0 673 623 Sep 1995 EP
0 685 201 Dec 1995 EP
0756416 Jan 1997 EP
0 776 149 May 1997 EP
0 858 773 Aug 1998 EP
2304017 Mar 1997 GB
3 109 057 Nov 1982 JP
62 222 780 Sep 1987 JP
8907322 Aug 1989 WO
9014793 Dec 1990 WO
9115786 Oct 1991 WO
9300046 Jan 1993 WO
9300649 Jan 1993 WO
9311707 Jun 1993 WO
9314418 Jul 1993 WO
9323952 Nov 1993 WO
9412855 Jun 1994 WO
9632064 Oct 1996 WO
9824059 Jun 1998 WO
9856214 Dec 1998 WO
9917659 Apr 1999 WO
9962404 Dec 1999 WO
Provisional Applications (1)
Number Date Country
60/179639 Feb 2000 US