Claims
- 1. An oxoazetidine compound of the formula: ##STR23## wherein R.sub.1 represents amino or amino substituted with a pharmaceutically acceptable carboxylic acyl protective group for the amino substituents in penicillin compounds,
- R.sub.3 represents a pharmaceutically acceptable carboxy, esterified carboxy which is esterified with lower alkyl, 1-cyclopropylethyl or trihalo(lower)alkyl, or salt of said carboxy group employed in penicillin compounds, and
- R.sub.2 represents a pharmaceutically acceptable group selected from the group consisting of quinolyl, lower alkanoyl and thiadiazolyl substituted by lower alkyl.
- 2. The oxoazetidine compound of claim 1, wherein R.sub.1 represents cyano(lower)alkanoylamino, phenyl(lower)alkanoylamino, phenoxy(lower)alkanoylamino, phenyl(lower)alkanoylamino substituted by lower alkoxycarbonylamino, phenyl(lower)alkanoylamino substituted by trihalo(lower)alkoxycarbonylamino, hydroxyphenyl(lower)alkanoylamino substituted by lower alkoxycarbonylamino, thienyl(lower)alkanoylamino, sydnonyl(lower)alkanoylamino or lower alkoxycarboxyl(lower)alkylideneamino, and R.sub.3 represents carboxy or esterified carboxy which is esterified with lower alkyl, 1-cyclopropylethyl or trihalo(lower)alkyl.
- 3. The oxoazetidine compound of claim 2, wherein R.sub.1 represents 2-cyanoacetamide, 2-phenylacetamide, 2-phenoxyacetamide, N-tertiary-butoxycarbonylphenylglycylamino, N-(2,2,2-trichloroethoxycarbonyl) phenylglycylamino, N-(1-cyclopropylethoxycarbonyl) phenylglycylamino, 2-(p-hydroxyphenyl)-2-(1-cyclopropylethoxy) carbonylaminoacetamido, 2-(thiophene-2-yl) acetamido, or 2-(sydnone-3-yl) acetamido, R.sub.3 represents carboxy or esterified carboxy which is esterified with methyl, 1-cyclopropylethyl or 2,2,2-trichloroethyl, and R.sub.2 represents quinoline-2-yl, 5-methyl-1,3,4-thiadiazole-2-yl or acetyl.
- 4. The oxoazetidine compound of claim 3, which is 2,2,2-trichloroethyl 4-(5-methyl-1,3,4-thiadiazole-2-yl)dithio-3-(2-phenylacetamido)-.alpha.-isopropenyl-2-oxoacetidine-1-acetate.
- 5. The oxoazetidine compound of claim 3, which is 4-(5-methyl-1,3,4-thiadiazole-2-yl)dithio-3-(2-phenoxyacetamide)-.alpha.-isopropenyl-2-oxoazetidine-1-acetic acid.
- 6. The oxoazetidine compound of claim 3, which is methyl 4-(quinoline-2-yl)dithio-3-(2-phenoxyacetamide)-.alpha.-isopropenyl-2-oxoazetidine-1-acetate.
- 7. The oxoazetidine compound of claim 3 which is methyl 4-(5-methyl-1,3,4-thiadiazole-2-yl)dithio-3-(2-phenoxyacetamide)-.alpha.-isopropenyl-2-oxoazetidine-1-acetate.
- 8. The oxoazetidine compound of claim 3, which is methyl-4-acetyldithio-3-(2-phenoxyacetamide)-.alpha.-isopropenyl-2-oxoazetidine-1-acetate.
Priority Claims (8)
Number |
Date |
Country |
Kind |
46-46158 |
Jun 1971 |
JPX |
|
46-61776 |
Aug 1971 |
JPX |
|
46-61777 |
Aug 1971 |
JPX |
|
46-62687 |
Aug 1971 |
JPX |
|
46-63885 |
Aug 1971 |
JPX |
|
46-63886 |
Aug 1971 |
JPX |
|
46-70018 |
Sep 1971 |
JPX |
|
46-2516 |
Dec 1971 |
JPX |
|
CROSS REFERENCES TO RELATED APPLICATIONS
This is a division of application Ser. No. 852,053 filed Nov. 16, 1977, now U.S. Pat. No. 4,367,340 which is a division of application Ser. No. 711,980, filed Aug. 5, 1976, now U.S. Pat. No. 4,071,527 which is a division of application Ser. No. 430,688, filed Jan. 4, 1974, now U.S. Pat. No. 3,993,646 which is a continuation-in-part of application Ser. No. 266,470, filed June 26, 1972, now abandoned.
US Referenced Citations (7)
Non-Patent Literature Citations (1)
Entry |
Barton et al. J.C.S. Chem Comm 1971, p. 1137. |
Divisions (3)
|
Number |
Date |
Country |
Parent |
852053 |
Nov 1967 |
|
Parent |
711980 |
Aug 1976 |
|
Parent |
430688 |
Jan 1974 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
266470 |
Jun 1972 |
|