Claims
- 1. A bioartificial device for releasing a hormone in a recipient patient, comprising: a matrix containing a hormone producing cellular moiety; and capsule means enveloping said matrix comprising a polymeric membrane selected from the group consisting of poly-para-xylylene, poly-monochloro-xylylene, and poly-dichloro-xylylene, said polymeric membrane having a molecular weight porosity at least as great as that necessary to permit passage of therethrough of nutrient for said cellular moiety and the hormone produced thereby, but less than that necessary to block passage therethrough of immunogenic agents.
- 2. A bioartificial device of claim 1 wherein said polymeric membrane has a molecular weight porosity of less than 160,000.
- 3. A bioartificial device of claim 1 wherein said polymeric membrane has a molecular weight porosity of less than 40,000.
- 4. A bioartificial device of claim 1 wherein said polymeric membrane is poly-para-xylylene.
- 5. A bioartificial device of claim 1 wherein said cellular moiety produces a thyroid hormone.
- 6. A bioartificial device of claim 1 wherein said polymeric membrane has a molecular weight porosity of a growth hormone.
- 7. A bioartificial device of claim 1 wherein said polymeric membrane has a porosity of an adrenal hormone.
- 8. A bioartificial device as recited in claim 1 wherein said polymeric membrane has a thickness of around 2,000 to 5,000 Angstroms.
- 9. A bioartificial device as recited in claim 1 wherein said matrix comprises a liquid.
- 10. A bioartificial device as recited in claim 1 wherein said matrix comprises a gel.
- 11. A bioartificial device as recited in claim 1 wherein said matrix comprises culture media.
- 12. A bioartificial device as recited in claim 1 wherein said polymeric membrane has a thickness less than 5,000 Angstroms.
- 13. A bioartificial device as recited in claim 1 wherein said membrane has a thickness of around 2,500 to 3,500 Angstroms.
- 14. A bioartificial device comprising: capsule means for containing insulin producing cells formed of a biocompatible material including a permeable membrane formed of poly-para-xylylene, said membrane having a thickness less than about 5,000 Angstroms and permitting the passage therethrough of insulin.
- 15. A bioartificial device as recited in claim 14 wherein said capsule means comprises a plurality of chambers having openings covered by said permeable membrane.
Parent Case Info
This application is a continuation of application Ser. No. 08/346,340, filed Nov. 28, 1994, now U.S. Pat. No. 5,614,205, which is a File Wrapper Continuation application of Ser. No. 07/841,973, filed Feb. 24, 1992, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5614205 |
Usala |
Mar 1997 |
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Continuations (2)
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Number |
Date |
Country |
Parent |
346340 |
Nov 1994 |
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Parent |
841973 |
Feb 1992 |
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