Claims
- 1. A vitamin B6 bisphosphonate conjugate having the structure:[O═P(OH)2]2C(R1,R2) where:R1=OH,H; R2=(CH2)n—X; n=1-10; X=vitamin B6 residue or a phosphorylated vitamin B6; or [O═P(OH)2]2—C(R1R2) whereR1=Y—X; Y=N,O,S X=vitamin B6 residue or a phosphorylated vitamin B6; and R2=H,alkyl, or aryl.
- 2. A composition useful for the treatment of conditions associated with abnormal calcium and phosphate metabolism, comprising:(a) an effective amount of a bisphosphonate conjugate having the structure: [O═P(OH)2]2—C(R1,R2), where:R1=OH,H; R2=(CH2)n—X; n=1-10; X=vitamin B6 residue or a phosphorylated vitamin B6; or [O═P(OH)2]2—C(R1R2) whereR1=Y—X; Y=N,O,S X=vitamin B6 residue or a phosphorylated vitamin B6; and R2=H,alkyl, or aryl; (b) and a pharmaceutically-acceptable excipient.
- 3. A pharmaceutical composition comprising(a) a compound of claim 1; and (b) a pharmaceutically-acceptable excipient.
- 4. A method for treating pathological conditions associated with abnormal calcium and phosphate metabolism in a mammal in need of such treatment comprising administering to said mammal a safe and effective amount of the compound of claim 1.
- 5. A method of treating an animal having conditions associated with abnormal calcium and phosphate metabolism, comprising administering to said animal a safe and effective amount of the composition of claim 3.
- 6. A composition comprising:(a) an effective amount of a bisphosphonate conjugate having the structure: [O═P(OH)2]2—C(R1,R2), where:R1=OH,H; R2=(CH2)n—X; n=1-10; X=vitamin B6 residue or a phosphorylated vitamin B6; and (b) and a pharmaceutically-acceptable excipient.
- 7. A composition comprising:(a) an effective amount of a bisphosphonate conjugate having the structure: [O═P(OH)2]2—C(R1R2) whereR1=Y—X; Y=N,O,S X=vitamin B6 residue or a phosphorylated vitamin B6; R2=H,alkyl, or aryl; and (b) a pharmaceutically-acceptable excipient.
- 8. A vitamin B6 bisphosphonate conjugate having the structure:[O═P(OH)2]2—C(R1,R2), whereR1=OH,H; R2=(CH2)n—X; n=1-10; X=vitamin B6 residue or a phosphorylated vitamin B6.
- 9. A vitamin B6 bisphosphonate conjugate having the structure:[O═P(OH)2]2—C(R1R2) whereR1=Y—X; Y=N,O,S X=vitamin B6 residue or a phosphorylated vitamin B6; and R2=H,alkyl, or aryl.
- 10. A method of treating an animal having conditions associated with abnormal calcium and phosphate metabolism comprising administering to said animal a safe and effective amount of the composition of claim 6.
- 11. A method of treating an animal having conditions associated with abnormal calcium and phosphate metabolism comprising administering to said animal a safe and effective amount of the composition of claim 7.
- 12. A method of treating an animal having conditions associated with abnormal calcium and phosphate metabolism comprising administering to said animal a safe and effective amount of the composition of claim 8.
- 13. A method of treating an animal having conditions associated with abnormal calcium and phosphate metabolism comprising administering to said animal a safe and effective amount of the composition of claim 9.
- 14. A compound which is 3-(N-[5′-phospho]-pyridoxylamino)-1-hydroxypropyliden-1,1-bisphosphonic acid.
- 15. A compound which is 3-(N-pyridoxylamino)-1-hydroxypropyliden-1,1-bisphosphonic acid.
- 16. A compound which is 1-(N-[5′-phospho]-pyridoxylamino)-methylen-1,1-bisphosphonic acid.
- 17. A compound which is 1-(N-pyridoxylamino)-methylen-1,1-bisphosphonic acid.
RELATED APPLICATION
This application claims priority from U.S. Provisional Patent Application No. 60/080,500 filed Apr. 2, 1998. The entire disclosure of the provisional application is considered to be part of the disclosure of the accompanying application and is hereby incorporated by reference.
US Referenced Citations (3)
Foreign Referenced Citations (2)
Number |
Date |
Country |
8800829 |
Feb 1988 |
WO |
9110646 |
Jul 1991 |
WO |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/080500 |
Apr 1998 |
US |