Claims
- 1. A compound having the formula: ##STR22## wherein X and Y are S or CH.sub.2 provided at least one of X and Y is S;
- Z is (CH.sub.2).sub.m wherein m is 0, 1 or 2 or sulfur such that the sulfur may be in any position along the chain;
- R.sub.1 is lower alkyl, benzyl, substituted benzyl wherein the substituent may be one or two of loweralkyl, halogen, hydroxy, amino, nitro or loweralkoxy; and loweralkyl substituted with a 5- or 6-membered heterocyclic ring;
- R.sub.2 is 3-indolylmethyl or substituted 3-indolylmethyl wherein the substituent may be loweralkyl, loweralkoxy or halogen;
- R.sub.3 is loweralkyl, hydroxyloweralkyl, benzyl, carboxyloweralkyl, aminoloweralkyl or substituted hydroxy benzyl wherein the substituent may be loweralkyl, loweralkoxy, hydroxy, halogen, amino or nitro.
- 2. A compound of claim 1 wherein Z is (CH.sub.2).sub.n and n is 1;
- R.sub.1 is as defined in claim 1;
- R.sub.2 is 3-indolylmethyl or substituted indolylmethyl wherein the substituent is methoxy or fluoro; and
- R.sub.3 is methyl, ethyl, hydroxymethyl or hydroxyethyl.
- 3. A compound of claim 1 wherein:
- Z is methylene;
- R.sub.1 is as defined in claim 1;
- R.sub.2 is 3-indolylmethyl; and
- R.sub.3 is hydroxyethyl.
- 4. The compound of claim 2 which is cyclo ##STR23##
- 5. The compound of claim 2 which is cyclo ##STR24##
- 6. The compound of claim 2 which is cyclo ##STR25##
- 7. The compound of claim 2 which is cyclo ##STR26##
- 8. The compound of claim 2 which is cyclo ##STR27##
- 9. The compound of claim 2 which is cyclo ##STR28##
- 10. The compound of claim 2 which is cyclo ##STR29##
- 11. A method for selectively inhibiting the release of insulin, glucagon and growth hormone which comprises administering to an animal an effective amount of a cyclic hexapeptide of claim 1.
- 12. A pharmaceutical composition comprising a therapeutically effective amount of the cyclic hexapeptide of claim 1 or the nontoxic acid addition salts thereof in a pharmaceutically acceptable liquid or solid carrier.
- 13. A compound having the formula: ##STR30## and protected derivatives thereof.
Parent Case Info
This is a continuation of application Ser. No. 446,938, filed Dec. 6, 1982, now abandoned.
US Referenced Citations (5)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0029579 |
Mar 1981 |
EPX |
Non-Patent Literature Citations (2)
Entry |
Brady, et al., Med. Chem. Symposium (Presentation). |
Life Sciences 34, 1371-1378 (1984). |
Continuations (1)
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Number |
Date |
Country |
Parent |
446938 |
Dec 1982 |
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