CAVEOLIN-1 RELATED METHODS FOR TREATING GLIOBLASTOMA WITH TEMOZOLOMIDE

Throughout this application, various publications are cited. The disclosure of these publications is hereby incorporated by reference into this application to describe more fully the state of the art to which this invention pertains.

BACKGROUND OF THE INVENTION

Glioblastoma multiforme (GBM) is the most common and most deadly primary brain tumor affecting adults. Despite advancements made in surgical, radiological, and chemo-therapies for this grade IV astrocytoma, prognoses have remained very poor: median survival time from diagnosis remains at 9-15 months with less than 10% of patients surviving beyond 5 years.1, 2 Caveolin-1 (Cav-1) is the principle structural protein responsible for the formation of caveolae, or invaginating microdomains in the cell membrane. The capacity for Cav-1 to associate with a wide variety of proteins has implicated it in a number of processes ranging from vesicular transport and cholesterol homeostasis to nitric oxide production and cell migration, among others.3-7 Its ability to regulate cell cycle progression and intracellular signal transduction have resulted in the substantial characterization of Cav-1 in many cancers, where it has been shown to act as both a tumor suppressor and tumor promoter depending on the tissue type.8-11 In gliomas, expression of Cav-1 appears to increase proportionally to tumor grade, with most GBM lesions exhibiting more intense Cav-1 immunoreactivity than their grade II and III counterparts. 12-14 However, little is currently known as to the role of Cav-1 as it relates to GBM in vivo. Recent in vitro studies conducted using the GBM-derived cell line U-87MG have demonstrated that Cav-1 acts as a putative tumor suppressor in GBM by downregulating α5β1 integrin expression and subsequent TGFβ/SMAD pathway activity.^{15 16}

SUMMARY OF THE INVENTION

This invention provides a method for treating a subject afflicted with glioblastoma multiforme comprising administering a therapeutically effective regimen of temozolomide to the glioblastoma multiforme-afflicted subject, wherein the subject's glioblastoma multiforme cells are known to be caveolin-1-positive.

This invention also provides a method for determining whether a subject afflicted with glioblastoma multiforme is likely to progress therapeutically in response to a therapeutically effective regimen of temozolomide comprising determining whether the subject's glioblastoma multiforme cells are caveolin-1-positive, whereby if the subject's glioblastoma multiforme cells are caveolin-1-positive, the subject is likely to progress therapeutically in response to a therapeutically effective regimen of temozolomide.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1. Stable Expression of Cav-1 in U-87MG Cells. (A) Expression levels of Cav-1 measured by immunoblot analyses of U-87MG cells transduced with either LV105 control or LV105 Cav-1 lentivirus. (B) Immunofluorescent staining of Cav-1 in transduced U-87MG cells. Magnification=40×.

FIG. 2. Cav-1 Mediates Major Proliferative and Cell-Survival Pathways. Western immunoblot analysis of LV105 control and LV105 Cav-1 U-87MG cells showing cyclin D1 and cleaved caspase-3 expression as well as phosphorylation status of ERK1/2, AKT, mTOR and RPS6 pathways, with respective total protein levels for loading controls. Total caspase 3 and GAPDH serve as loading controls for cleaved caspase-3 and cyclin D1, respectively.

FIG. 3. U-87MG Cells Stably Overexpressing Cav-1 Exhibit Decreased Tumor Growth In Vivo. (A) Tumor weight and (B) tumor volume of U-87MG xenografts grown in athymic nu/nu male mice after 4 weeks (n=30 per group, ***p<0.001).

FIG. 4. Cav-1 Overexpressing Tumors Show Reduced Signaling Activity In Vivo. Immunohistochemical staining of explained tumors for Cav-1, cyclin D1, and phosphorylated ERK1/2, mTOR, and RPS6 (magnification=60×).

FIG. 5. Cav-1 Confers Chemosensitivity in U-87MG Cells. Annexin V and propidium iodide staining of U-87MG cells treated with either DMSO control or 500 μm TMZ reveals percentages of (A) live cells, (B) early apoptotic cells, (C) late apoptotic cells, and (D) dead cells as measured by flow cytometry. Each group is normalized to its own DMSO control (*p<0.05 and **p<0.01 vs internal DMSO control, \p<0.01 vs TMZ treated LV105 control, n=3 per group).

FIG. 6. Schematic Representation of the Role of Cav-1 in Glioblastoma. Gliomas are highly heterogeneous tumors that have been demonstrated to contain populations of cells with varied levels of Cav-1 expression. In this case, enhanced Cav-1 expression among a tumor cell prevents the activation of the TGFBRI/SMAD pathway, which in turn suppresses, at the transcriptional level, expression of integrin subunits and their subsequent signaling activity. Increased Cav-1 expression is also correlated with a decrease in the availability of matrix metallopeptidases, downregulated activity of the Erk1/2, PI3K/Akt and mTOR signaling pathways as well as the inhibition of the trans-membrane drug exporter p-gp. Together, this may implicate that tumors with increased Cav-1 levels are less likely to progress through the cell cycle or invade into surrounding tissues and are primed to undergo P53 mediated apoptosis, making these cells more easily targeted by standard chemotherapy regimens.

DETAILED DESCRIPTION OF THE INVENTION

Preferably, the subject is human, and the glioblastoma multiforme is newly diagnosed in the subject.

The subject can be any animal capable of being afflicted with glioblastoma multiforme.

In this invention, cells that are caveolin-1-positive are determined to be such according to methods known in the art. Such methods include the antibody-based methods described herein.

In one embodiment, the subject's glioblastoma multiforme cells known to be caveolin-1-positive express an amount of caveolin-1 that is a percentage of the amount of caveolin-1 expressed by the lentiviral transduced caveolin-1-overexpressing U-87MG cells described herein, wherein the percentage is selected from below 10%, 10%-20%, 20%-30%, 30%-40%, 40%0-50%, 50%-60%, 60%-70%, 70%-80%, 80%-90%, 90%-100%, 100%-120%, 120%-140%, 140%-160%, 160%-180%, 180%-200%, and above 200%.

Temozolomide (available from Schering-Plough as Temodar® (“Temodar”)) is a known therapeutic for treating glioblastoma multiforme. Typically, it is administered in conjunction with radiotherapy and/or surgery. Although numerous regimens of temozolomide are possible, the regimens set forth in in the Temodar label are preferred. Certain portions of that label are reproduced below, although the label's contents at http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021029s0121bI.pdf are incorporated herein in their entirety.

Temodar Description

Temodar Capsules for oral administration contain temozolomide, an imidazotetrazine derivative. The chemical name of temozolomide is 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-αs-tetrazine-8-carboxamide.

The material is a white to light tan/light pink powder with a molecular formula of C6H6N6O2 and a molecular weight of 194.15. The molecule is stable at acidic pH (<5), and labile at pH>7, hence Temodar can be administered orally. The prodrug, temozolomide, is rapidly hydrolyzed to the active 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC) at neutral and alkaline pH values, with hydrolysis taking place even faster at alkaline pH.

Each capsule contains either 5 mg, 20 mg, 100 mg, 140 mg, 180 mg, or 250 mg of temozolomide. The inactive ingredients for Temodar Capsules are lactose anhydrous, colloidal silicon dioxide, sodium starch glycolate, tartaric acid, and stearic acid. The 5 mg, 20 mg, 100 mg, and 250 mg gelatin capsule shells contain titanium dioxide. The capsules are white and imprinted with pharmaceutical ink. The body of the capsules for the 140 mg and 180 mg strengths is made of gelatin, and is opaque white. The cap is also made of gelatin, and the colors vary based on the dosage strength.

Temodar 5 mg: green imprint contains pharmaceutical grade shellac, anhydrous ethyl alcohol, isopropyl alcohol, n-butyl alcohol, propylene glycol, ammonium hydroxide, titanium dioxide, yellow iron oxide, and FD&C Blue #2 aluminum lake.

Temodar 20 mg: brown imprint contains pharmaceutical grade shellac, anhydrous ethyl alcohol, isopropyl alcohol, n-butyl alcohol, propylene glycol, purified water, ammonium hydroxide, potassium hydroxide, titanium dioxide, black iron oxide, yellow iron oxide, brown iron oxide, and red iron oxide.

Temodar 100 mg: blue imprint contains pharmaceutical glaze (modified) in an ethanol/shellac mixture, isopropyl alcohol, n-butyl alcohol, propylene glycol, titanium dioxide, and FD&C Blue #2 aluminum lake.

Temodar 140 mg: The blue cap contains gelatin, sodium lauryl sulfate, FD&C Blue #2, and titanium dioxide. The capsule body and cap are imprinted with pharmaceutical branding ink, which contains shellac, dehydrated alcohol, isopropyl alcohol, butyl, alcohol, propylene glycol, purified water, strong ammonia solution, potassium hydroxide, and ferric oxide.

Temodar 180 mg: The red cap contains gelatin, sodium lauryl sulfate, titanium dioxide, iron oxide red and iron oxide yellow. The capsule body and cap are imprinted with pharmaceutical branding ink, which contains shellac, dehydrated alcohol, isopropyl alcohol, butyl alcohol, propylene glycol, purified water, strong ammonia solution, potassium hydroxide, and ferric oxide.

Temodar 250 mg: black imprint contains pharmaceutical grade shellac, anhydrous ethyl alcohol, isopropyl alcohol, n-butyl alcohol, propylene glycol, purified water, ammonium hydroxide, potassium hydroxide, and black iron oxide.

Temodar Clinical Studies

Newly Diagnosed Glioblastoma Multiforme. Five hundred and seventy three patients were randomized to receive either Temodar (TMZ)+Radiotherapy (RT) (n=287) or RT alone (n=286). Patients in the Temodar+RT arm received concomitant Temodar (75 mg/m2 ) once daily, starting the first day of RT until the last day of RT, for 42 days (with a maximum of 49 days). This was followed by 6 cycles of Temodar alone (150 or 200 mg/m2) on Day 1-5 of every 28-day cycle, starting 4 weeks after the end of RT. Patients in the control arm received RT only. In both arms, focal radiation therapy was delivered as 60 Gy/30 fractions. Focal RT includes the tumor bed or resection site with a 2-3 cm margin. Pneumocystis carinii pneumonia (PCP) prophylaxis was required during the TMZ+radiotherapy treatment, regardless of lymphocyte count, and was to continue until recovery of lymphocyte count to less than or equal to Grade 1.

At the time of disease progression, Temodar was administered as salvage therapy in 161 patients of the 282 (57%) in the RT alone arm, and 62 patients of the 277 (22%) in the Temodar+RT arm. The addition of concomitant and maintenance Temodar to radiotherapy in the treatment of patients with newly diagnosed GBM showed a statistically significant improvement in overall survival compared to radiotherapy alone (FIG. 1). The hazard ratio (HR) for overall survival was 0.63 (95% CI for HR=0.52-0.75) with a logrank p<0.0001 in favor of the Temodar arm. The median survival was increased by 2½ months in the Temodar arm.

Temodar Indications and Usage

Temodar (temozolomide) Capsules are indicated for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as maintenance treatment.

Temodar Dosage and Administration

Dosage of Temodar Capsules must be adjusted according to nadir neutrophil and platelet counts in the previous cycle and the neutrophil and platelet counts at the time of initiating the next cycle. For Temodar dosage calculations based on body surface area (BSA) see assigned Table. For suggested capsule combinations on a daily dose see assigned Table.

Patients with Newly Diagnosed High Grade Glioma:

Concomitant Phase

Temodar is administered orally at 75 mg/m2 daily for 42 days concomitant with focal radiotherapy (60 Gy administered in 30 fractions) followed by maintenance Temodar for 6 cycles. Focal RT includes the tumor bed or resection site with a 2-3 cm margin. No dose reductions are recommended during the concomitant phase; however, dose interruptions or discontinuation may occur based on toxicity. The Temodar dose should be continued throughout the 42 day concomitant period up to 49 days if all of the following conditions are met: absolute neutrophil count ≧1.5×10⁹/L platelet count ≧100×109/L common toxicity criteria (CTC) non-hematological toxicity ≦Grade 1 (except for alopecia, nausea, and vomiting). During treatment, a complete blood count should be obtained weekly. Temozolomide dosing should be interrupted or discontinued during concomitant phase according to the hematological and non-hematological toxicity criteria. PCP prophylaxis is required during the concomitant administration of Temodar and radiotherapy and should be continued in patients who develop lymphocytopenia until recovery from lymphocytopenia (CTC grade ≦1).

Maintenance Phase Cycle 1:

Four weeks after completing the Temodar+RT phase, Temodar is administered for an additional 6 cycles of maintenance treatment. Dosage in Cycle 1 (maintenance) is 150 mg/m2 once daily for 5 days followed by 23 days without treatment.

Cycles 2-6:

At the start of Cycle 2, the dose is escalated to 200 mg/m2, if the CTC non hematologic toxicity for Cycle 1 is Grade ≦2 (except for alopecia, nausea, and vomiting), absolute neutrophil count (ANC) is ≧1.5×109/L, and the platelet count is ≧100×109/L. The dose remains at 200 mg/m2 per day for the first 5 days of each subsequent cycle except, if toxicity occurs. If the dose was not escalated at Cycle 2, escalation should not be done in subsequent cycles.

Dose reduction or discontinuation during maintenance:

During treatment, a complete blood count should be obtained on Day 22 (21 days after the first dose of Temodar) or within 48 hours of that day, and weekly until the ANC is above 1.5×109/L, (1,500/μL) and the platelet count exceeds 100×10⁹/L (100,000/μL). The next cycle of Temodar should not be started until the ANC and platelet count exceed these levels. Dose reductions during the next cycle should be based on the lowest blood counts and worst non-hematologic toxicity during the previous cycle.

This invention will be better understood by reference to the Experimental Details which follow, but those skilled in the art will readily appreciate that the specific experiments detailed are only illustrative of the invention as described more fully in the claims which follow thereafter.

EXPERIMENTAL DETAILS
Abbreviations

Caveolin-1 (Cav-1), glioblastoma multiforme (GBM), mitogen activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), ribosomal protein S6 (RPS6), mammalian target of rapamycin (mTOR), temozolomide (TMZ), transforming growth factor beta (TGFβ), transforming growth motor beta receptor I (TGFβRI), tumor protein 53 (TP53), phosphate and tensin homolog (PTEN), permeability glycoprotein (p-gp)

Synopsis

Caveolin-1 (Cav-1) is a critical regulator of tumor progression in a variety of cancers where it has been shown to act as either a tumor suppressor or tumor promoter. In glioblastoma multiforme, it has been previously demonstrated to function as a putative tumor suppressor. Our studies here, using the human glioblastoma-derived cell line U-87MG, further support the role of Cav-1 as a negative regulator of tumor growth. Using a lentiviral transduction approach, we were able to stably overexpress Cav-1 in U-87MG cells. Gene expression microarray analyses demonstrated significant enrichment in gene signatures corresponding to downregulation of MAPK, PI3K/AKT, and mTOR signaling, as well as activation of apoptotic pathways in Cav-1 overexpressing U-87MG cells. These same gene signatures were later confirmed at the protein level in vitro. To explore the ability of Cav-1 to regulate tumor growth in vivo, we further show that Cav-1 overexpressing U-87MG cells display reduced tumorigenicity in an ectopic xenograft mouse model, with marked hypoactivation of MAPK and PI3K/mTOR pathways. Finally, we demonstrate that Cav-1 overexpression confers sensitivity to the most commonly used chemotherapy for glioblastoma, temozolomide. In conclusion, Cav-1 negatively regulates key cell growth and survival pathways and may be an effective biomarker for predicting response to chemotherapy in glioblastoma.

RESULTS
Stable Expression of Cav-1 in U-87MG Cells

In order to establish durable expression of Cav-1 over time in a cell line model, we chose to use a lentiviral transduction approach over the transient transfection methods used in previous in vitro studies.15,16 After selection with puromycin, U-87MG cells transduced with lentiviral constructs stably expressing full length Cav-1 cDNA (LV105 Cav-1) were shown to effectively upregulate Cav-1 compared to an empty control lentivirus (LV105 Control) as demonstrated by western immunoblot (FIG. 1A). Changes in Cav-1 protein expression were also confirmed by immunofluorescence, where overexpressing cells demonstrated increased cytoplasmic and membrane localization of Cav-1 following lentiviral transduction (FIG. 1B).

Cav-1 Regulates Cancer-Associated Gene Expression

Using a microarray consisting of >20,000 transcript probes, we were able to identify 2,001 genes (˜10%) significantly modulated by Cav-1 overexpression (Tables 1, 2, S1 and S2). Gene set enrichment analyses performed on microarray expression data obtained from LV105 Control and LV105 Cav-1 U-87MG cells indicates that Cav-1 expression corresponds to changes in a variety of cancer-associated gene signatures. Specifically, by comparing expression data to biological process gene ontology sets, it was found that Cav-1-overexpressing U-87MG cells demonstrated significant (p<0.001) enrichment among gene sets related to negative regulation of signal transduction, MAP-kinase activity, cell proliferation, and transcription (Tables 2 and S1). Signatures related to caspase activation, apoptosis, and the transforming growth factor β pathway were also highly enriched (Tables 2 and S1). When expression data was compared to a curated canonical pathway database, gene sets related to PI3K/AKT, mTOR, and ERK signaling, as well as cell death and extracellular matrix signaling were found to be significantly enriched (Tables 2 and S1).

Cav-1 Mediates Major Proliferative and Cell-Survival Pathways

To validate the results obtained from our microarray analyses, we next sought to confirm Cav-1 mediated modulation of intracellular signaling pathways at the protein level. Overexpression of Cav-1 in U-87MG cells results in abrogated activity of proliferative pathways as shown by reduced phosphorylation of ERK1/2 and decreased expression of the cell cycle driver cyclin D1 when compared to control as shown by western immunoblot (FIG. 2A). Overexpression of Cav-1 further reduced the activity of protein synthesis pathways as shown by reduced activation of the AKT/mTOR/ribosomal protein S6 (RPS6) signaling pathways (FIG. 2B). Additionally, U-87MG cells overexpressing Cav-1 demonstrated increased presence of the apoptosis activator cleaved caspase 3 (FIG. 2C).

U-87MG Cells Stably Overexpressing Cav-1 Exhibit Decreased Tumor Growth In Vivo

To evaluate the ability of Cav-1 to regulate tumorigenicity in vivo, U-87MG cells infected with either Cav-1-expressing or control lentivirus were injected subcutaneously into the flanks of athymic nu/nu male mice. After 4 weeks, mice were sacrificed and tumors were collected, weighed, and measured. Importantly, mice harboring Cav-1 overexpressing tumors demonstrated markedly reduced (˜7 fold) tumor weights and volumes as compared to their control counterparts (p<0.001, FIGS. 3A and 3B).

Cav-1 Overexpressing Tumors Show Reduced Signaling Activity In Vivo

Similar to results obtained in vitro, our immunohistochemical analyses show that explanted xenograft tumors overexpressing Cav-1 demonstrate fewer cells staining positive for Phospho-ERK1/2 and cyclin D1 (FIG. 4). Additionally, RPS6 and MTOR pathways were shown to be silenced in LV105 Cav-1 tumors as shown by the absence of their active, phosphorylated isoforms (FIG. 4).

Cav-1 Confers Chemosensitivity in U-87MG Cells

To further examine the effect of Cav-1 on chemotherapeutic-induced apoptosis, U-87MG cells were stained for the cell death marker Annexin V and measured by flow cytometry. Cav-1 overexpressing U-87MG cells cultured for 72 hours in the presence of 500 μM of temozolomide (TMZ), the most commonly used chemotherapeutic for GBM, showed significant reductions in cell viability when compared to TMZ treated LV105 control cells (5.5%, p<0.01, FIG. 5A). This effect was found to be most pronounced among cells initiating apoptosis, as Cav-1-overexpressing U-87MG cells treated with TMZ demonstrated >400% increase in early apoptotic cells compared to TMZ-treated LV105 control cells (p<0.01, FIG. 5B). Interestingly, although not statistically significant, overexpression of Cav-1 yielded expanded late-apoptotic and dead cells after 72 hours of TMZ treatment (FIG. 5C, D).

DISCUSSION

Although it has been, demonstrated that Cav-1 expression in glioma increases variably in accordance with grade, little is currently known about its biological effects on tumor onset and progression.12-14, 17, 18 Previous in vitro studies using transient transfection techniques have shown that loss of Cav-1 in U-87MG cells resulted in the adoption of a more proliferative and invasive phenotype whereas its forced overexpression conferred the opposite effects.15 In line with previous studies, we here show that Cav-1 functions as a putative tumor suppressor in glioblastoma. Using a novel lentivirus transduction system we created a stable Cav-1 overexpressing cell line based on the U-87MG background.

By subjecting transiently transfected U-87MG cells to a panel of reverse transcription-PCR printers, Martin et al. identified genes pertaining to cell invasion, metastasis, and cell adhesion as those being the most differentially regulated by Cav-1 expression. Particularly, they showed the integrin genes ITGA1, ITGA3, ITGA5, ITGAV, ITGB1, and ITGB5 were significantly down regulated in Cav-1 overexpressing cells, with cells treated with Cav-1 specific siRNA demonstrating marked upregulation of these same genes. Matrix metallopeptidase genes MMP1 and MMP2, as well as transforming growth factor beta receptor I (TGFRBI) were also shown to be significantly modulated by Cav-1.15 A follow up study using Cav-1 silenced U-87MG cells further clarified a mechanism in which Cav-1 acts as a negative regulator of integrin signaling by inhibiting the expression of these integrins themselves as well as sequestering downstream TGFβ/TGFβRI/SMAD2 and ERK pathways.16 Here, we implemented a similar, albeit much more expansive microarray-based approach to study gene perturbations as a result of Cav-1 overexpression. Using gene set enrichment analyses, we indeed show similar expression profiles to those found previously, with gene sets related to integrin interactions, as well as regulation of TGFβ receptor/SMAD pathways showing significant enrichment. In our study, however, we detected a multitude of other significantly enriched gene sets which have not been demonstrated previously in Cav-1 expressing GBM cells. For instance, U-87MG cells overexpressing Cav-1 demonstrated significant upregulation of genes responsible for negative regulation of signal transduction, particularly within ERK, PI3K/AKT, and mTOR pathways. Although it has long been known that Cav-1 serves to negatively regulate the activity of p42/p44 (ERK1/2) signaling proteins of the MAPK pathway, our evidence also suggests it has the capability to sequester PI3K and mTOR activity.20-26 This is notable due to the fact that ERK, PI3K and mTOR signaling axes are frequently unregulated in GBM, suggesting that loss of Cav-1 could lead to unchecked activation of these pathways.27-31 Two of the most commonly silenced genes in GBM are the tumor suppressor proteins PTEN and TP53, which serve to antagonize the PI3K/AKT/mTOR pathway and regulate cell cycle, response to DNA damage and cell death, respectively.32 Of note is that these two genes were among the most unregulated in cells overexpressing Cav-1, which would likely explain the gene signatures corresponding to downregulation of signaling pathways and reduced invasiveness.

A major hallmark of GBM is the ability of tumor cells to invariably metastasize to distant sites in the CNS despite aggressive treatment. This is often attributed to the excessive release of matrix metallopeptidases and urokinase plasminogen activator.33 Here we show that the genes MMP1, MMP3, and PLAU (urokinase plasminogen activator) are highly downregulated in our Cav-1 overexpressing U-87MG cells, which is consistent with reports that Cav-1 negatively regulates tumor invasiveness.15, 34-36 These genes have been shown to be regulated by Erk and TP53, therefore, their reduction may be secondary to Cav-1 modulation of these pathways.37-40

Of note, we also found that genes responsible for sequestering cell cycle progression and transcription were overexpressed in LV105 Cav-1 cells (FOXN3, HDAC5, VHL, CDKNIC, among others). Conversely, genes responsible for progression through cell cycle such as CCND1 (cyclin D1) were found to be significantly downregulated in Cav-1 overexpressing cells, consistent with previous reports that Cav-1 transcriptionally represses cyclin D1.8 Perhaps our most notable finding, however, is that a substantial number of genes involved in the activation of apoptotic and cell death pathways are increased as a result of Cav-1 overexpression (TP53, MOAP1, CASP3, CASP9, BCL2L11, BAK1, BID among others). Although the role of Cav-1 in apoptosis is contentious, with reports indicating both pro- and anti-cell death roles, it may be possible that expression of Cav-1 promotes apoptotic activity in U-87MG cells by inhibiting the BIRC5 gene product, survivin, as is suggested here and in previous reports.41-45 In support of these microarray data, we were able to demonstrate, at the protein level, silencing of ERK, AKT, mTOR, RPS6, and cyclin D1 pathways with corresponding activation and cleavage of the key apoptosis initiator caspase 3.

Importantly, we here show for the first time that forced expression of Cav-1 in vivo results in a dramatic reduction of tumor burden in U-87MG xenografts. Although Cosset et al. have demonstrated that explanted human glioma tissue lacking Cav-1 expression results in increased expression of α5β1 integrin subunits, we were able to demonstrate a direct inverse relationship with Cav-1 expression and cell proliferation in an animal model.16 In line with our in vitro data, these xenograft tumors displayed reduced activity of ERK, RPS6, and mTOR pathways. As these pathways have been previously shown to play major roles in glioma progression, it is likely that Cav-1 could act as a critical regulator of tumor growth and protein synthesis in a clinical setting. As examples of this, studies have shown that exogenous administration of cavtratin, or a soluble peptide consisting of the Cav-1 scaffolding domain fused to an internalization domain, results in reduced MAPK activity in oligodendroglial cells in vivo, as well as reduced tumor volumes in a xenograft model of Lewis Lung Carcinoma.23,46 A separate study demonstrated that in vitro administration of full length Cav-1 prevented invasion of three different GBM-derived cell lines using a Boyden-chamber assay.47 In this regard, it may be suggested that Cav-1 be explored as a therapeutic agent in GBM.

Lastly, we have also demonstrated that expression of Cav-1 confers sensitivity to the most commonly used chemotherapeutic in GBM, temozolomide. This could be due in part to the action of the permeability glycoprotein (P-gp) transporter, a multidrug exporter which normally prevents the influx of drugs across the blood brain barrier. However, cancerous cells can also express this protein, rendering treatment of GBM with conventional chemotherapeutics less effective.48 Cav-1 has been shown to associate with P-gp and negatively regulate its activity, therefore overexpression of Cav-1 most likely results in improved access of TMZ to the intracellular compartment of U-87MG cells in our model.49, 50 Interestingly, a separate study showed that treatment with TMZ resulted in upregulation of Cav-1 expression in vivo using orthotopic GBM xenograft models.47 In light of our data, this could suggest a positive feedback loop exists in which treatment with TMZ serves to auto-sensitize GBM cells through a Cav-1 dependent mechanism. This finding implicates Cav-1 as a potential biomarker predicting response to chemotherapies for GBM as it has been shown for other cancers such as breast, lung, and oral squamous cell carcinomas.51-53

Taken together, these studies confirm and expand upon previous work identifying Cav-1 as a putative tumor suppressor in GBM. We here show that stable overexpression of Cav-1 in a widely used model of GBM results in silencing of key proliferative and cell survival pathways in vitro as well as in vivo. Additionally, we have demonstrated its ability to modulate sensitivity to commonplace chemotherapeutics for GBM. These findings highlight the potential of Cav-1 to serve as a novel biomarker indicating potential response to therapy and also a candidate therapy for treatment of GBM.

MATERIALS AND METHODS
Cell Lines and Reagents

The human glioblastoma-derived cell line U-87MG was obtained from American Type Culture Collection (ATCC) and cultured in Eagle's Modified Essential Medium (EMEM, ATCC) supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin (Life Technologies). Cells were cultured in the presence of 5% CO2 at 37° C. Temozolomide (TMZ) was obtained from Sigma-Aldrich and dissolved in DMSO to a concentration of 100 mM. The following antibodies were used: mouse anti-Caveolin-1 (2297, BD Bioscience), rabbit anti-Caveolin-1 (N-20), mouse anti-cyclin D1 (DCS-6, Santa Cruz Biotechnology), rabbit anti-phospho mTOR (Se2448, D9C2, Cell Signaling), rabbit anti-phospho-ERK1/2 (Thr202/Tyr204, Cell Signaling), rabbit anti-phospho-AKT (Ser473, D9E, Cell Signaling), rabbit anti-phospho-ribosomal S6 (Ser235/236, 91B2, Cell Signaling) rabbit anti-ERK1/2 (Cell Signaling), rabbit anti-AKT (Cell Signaling), rabbit anti-ribosomal S6 (5G10, Cell Signaling), rabbit anti-cleaved caspase 3 (Asp175, Cell Signaling), rabbit anti-caspase 3 (Cell Signaling), and mouse anti-GAPDH (6C5, Fitzgerald Industries).

Stable Lentiviral Transduction of U-87MG Cells

Plasmids Ex-Neg-LV105 (empty control vector) and Ex-D0159-LV105 (Cav-1 c-DNA vector) were obtained from Genecopoeia and transfected into the packaging cell line Genecopoeia 293Ta using the Lenti-Pac HIV Expression Packaging Kit as per manufacturer's instructions, 48 hours post-transfection, lentivirus containing supernatants were collected and centrifuged at 500×g for 10 minutes to clear cellular debris. U-87MG cells were cultured in viral supernatants supplemented with 5 μg/ml polybrene (Santa Cruz) for 24 hours prior to changing back into complete medium containing 2.5 μg/ml puromycin hydrochloride (Santa Cruz) to select for lentiviral-transduced cells. After one week of selection, cells were allowed to grow in complete medium without puromycin.

Western Immunoblot

Cells at 70% confluence were collected, pelleted at 300×g, washed twice with Dulbecco's PBS (DPBS) and resuspended in RIPA lysis buffer (50 mM Tris, 150 mM NaCl, 0.5% sodium deoxycholate, 1% Triton X-100, 0.1% SDS, pH 7.5) including Complete Protease Inhibitor Cocktail (Roche Diagnostics) and Halt Phosphatase Inhibitor Cocktail (Thermo-Scientific). Lysates were sonicated and centrifuged at 10,000×g for 10 min to clear cellular debris prior to protein quantification by BCA assay (Thermo-Scientific) as per manufacturer's instructions. Proteins were separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE; 8-12% acrylamide), transferred to nitrocellulose membranes (Whatman), and blocked for 1 hour in TBST (10 mM Tris, 150 mM NaCl, 0.05% Tween-20, pH 8.0) with 5% bovine serum albumin (BSA). Membranes were incubated with primary antibodies diluted in TBST+1% BSA overnight at 4° C. followed by incubation in either horseradish peroxidase (HRP) conjugated anti-mouse (Thermo-Scientific) or anti-rabbit (BD Biosciences) antibodies. Detection of bound antibodies was accomplished with the use of Supersignal chemiluminescent substrates (Thermo-Scientific).

Immunofluorescence Analysis

U-87MG cells grown on glass coverslips in 6 -well plates were fixed in ice-cold methanol for 20 min, washed with PBS, and incubated with anti-Cav-1 primary antibody (BD Bioscience) in immunofluorescence (IF) buffer (PBS+5% BSA, 0.5% NP40) for 30 min at 37° C. before incubation with secondary fluorescein isothiocyanate (FITC)-conjugated anti-mouse antibody (Jackson Labs) in IF buffer. Cells were counterstained with Hoechst nuclear dye (Life Technologies) prior to coverslipping and visualization with a Zeiss LSM 510 confocal microscope (Carl Zeiss Microscopy).

Gene Array

DNA microarray analysis was performed using the Human Whole Genome OneArray v2 (Phalanx Biotech, Belmont, Calif.). RNA quality and integrity were determined utilizing an Agilent 2100 Bioanalyzer (Agilent Technologies) and absorbance at A260/A280. Only high quality RNA, having a RIN of >7.0, and an A260/280 absorbance ratio of >1.8, was utilized for further experimentation, RNA was synthesized to double-stranded cDNA and amplified using in vitro transcription that included amino-allyl UTP, and the aRNA product was subsequently conjugated with with Cy5 NHS ester (GE Healthcare Lifesciences). Fragmented aRNA was hybridized at 42° C. overnight using the HybBag mixing system with 1X OneArray Hybridization Buffer (Phalanx Biotech), 0.01 mg/ml sheared salmon sperm DNA (Promega), at a concentration of 0.025 mg/ml labeled target. After hybridization, the arrays were washed according to the OneArray protocol. Raw intensity signals for each microarray were captured using a Molecular Dynamics™ Axon 4100A scanner, measured using GenePixPro™ Software. Significantly up- or down-regulated genes in LV105 Cav-1 cells were identified as having normalized intensities above background (>50), a fold change of ±1.5 compared to control, and p<0.05.

Gene Set Enrichment Analyses

Pre-processed expression data was subjected to Gene Set Enrichment Analysis using C5.BP.V3.0 (gene ontology: biological processes) and C2.CP.V3.0 (canonical pathways) MSigDB gene sets.54,55 Genes expression data were ordered based on a signal-2-noise metric and compared statistically to existing gene sets at a resolution of 1,000 permutations. Statistical significance of gene set enrichment was assumed at nominal p<0.05, with a false discovery rate (FDR) q<0.25.

Tumor Xenografts

All animal studies were conducted in accordance with the guidelines set forth by the National Institutes of Health and the Thomas Jefferson University Institutional Animal Care and Use Committee (IACUC). Briefly, U-87MG cells were washed with DPBS, trypsinized, counted, and resuspended in a volume of complete medium yielding 1×106 cells/50 μl, which was subsequently injected subcutaneously into the flanks of 6-8 week old male athymic nu/nu mice (NCI). After 4 weeks, mice were sacrificed and tumors were excised, weighed and measured prior to further processing.

Immunohistochemistry

Explanted xenograft tumors were fixed in 10% phosphate buffered formalin solution for 24 hours prior to dehydration in 70% ethanol, paraffin embedding, and sectioning onto slides. Following xylene deparaffinizaiton and rehydration, slides were subjected to 10 minutes of heat antigen retrieval in 10 mM sodium citrate buffer pH 6.0 and endogenous peroxide quenching in 3% hydrogen peroxide for 20 min. Tissues were blocked in 10% normal goat serum (NGS, Vector Labs, Burlingame, Calif.) for 1 hour at room temperature and incubated overnight with primary antibody in 10% NGS at 4° C. Slides were then washed in PBS and blocked with Biotin-Blocking System (Dako) before incubating with the appropriate secondary antibody in PBS and developing with 3,3-diaminobenzidine (DAB) substrate (Dako). Slides were counterstained with hematoxylin (Sigma), dehydrated, and coverslipped prior to imaging with an Olympus BX51 light microscope equipped with a Micropublisher 5.0 CCD camera (QImaging).

Flow Cytometry

U-87MG cells (50,000/well) were plated in 12-well tissue culture dishes and allowed to attach overnight prior to changing their medium into complete EMEM containing either 500 μM TMZ or DMSO control and culturing them for an additional 72 hours. Cells were then trypsinized, centrifuged at 300×g for 5 min and resuspended in binding buffer with APC-conjugated anti-Annexin V antibody (BP Biosciences) and 0.33 μg/ml Propidium Iodide (PI, KPL, Gaithersburg, Md.). All samples were run on a BD FACSCalibur flow cytometer (BD Biosciences). Cells were quantified according to staining as follows: viable (Annexin V negative, PI negative), early apoptotic (Annexin V positive, PI negative), late apoptotic (Annexin V positive, PI positive), and dead (Annexin V negative, PI positive).

Statistical Analysis

All data were expressed as mean±SEM Differences between groups were evaluated by either unpaired Student's t-test or one-way ANOVA followed by Tukey's multiple-group comparisons test, where appropriate. Statistical significance was assumed at p<0.05.

Table 1: Differential Gene Expression of Cav-1 Overexpressing U-87MG Cells

Top 100 microarray hits demonstrating the most significantly up- and downregulated genes in Cav-1 overexpressing U-87MG cells. For a complete list see Table S2. (n=3 samples from each group).

Table 2: Cav-1 Regulates Cancer-Associated Gene Expression

Enrichment score (ES), normalized enrichment score (NES), nominal p-value, and false discovery rate (FDR) q-value for selected gene sets enriched in LV105 Cav-1 cells vs control using (A) gene ontology: biological process and (B) canonical pathway molecular signature databases (n=3 samples from each group). For a detailed list of genes see Table S1.

Table S1: Gene Set Enrichment Data

Expanded Gene Set Enrichment Analysis for (A) gene ontology: biological process and (B) canonical pathway molecular signature databases (n=3 samples from each group).

Table S2: Differential Gene Expression of Cav-1 Overexpression U-87MG Cells

Top microarray hits demonstrating, the most significantly up- and downregulated genes in Cav-1 overexpressing U-87MG cells (fold change >±1.5 vs LV105 control, p<0.05, n=3 samples from each group).

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TABLE 1

Differential Gene Expression of Cav-1 Overexpressing U-87MG Cells. Top 100 microarray hits demonstrating the most significantly up-

and downregulated genes in Cav-1 overexpressing U-87MG cells. For a complete list see Table S2. (n = 3 samples from each group).

PROBE
FOLD CHANGE
P-VALUE
DESCRIPTION

CCDC3
94.19
0.00E+00
coiled-coil domain containing 3

COL3A1
75.99
0.00E+00
collagen, type III, alpha 1

MTUS1
46.14
2.77E−10
microtubule associated tumor suppressor 1

NUP210
34.18
5.08E−24
nucleoporin 210 kDa

COL4A1
30.33
1.38E−22
collagen, type IV, alpha 1

APOE
24.59
0.00E+00
apolipoprotein E

LRRC17
21.54
0.00E+00
leucine rich repeat containing 17

PRL
16.66
1.07E−22
prolactin

SULF1
16.35
5.88E−20
sulfatase 1

UBE2QL1
15.93
0.00E+00
ubiquitin-conjugating enzyme E2Q family-like 1

FAT3
14.40
0.00E+00
FAT tumor suppressor homolog 3 (Drosophila)

CSAG1
13.78
0.00E+00
chondrosarcoma associated gene 1

SOX4
12.86
1.89E−26
SRY (sex determining region Y)-box 4

CTNNA2
12.75
0.00E+00
catenin (cadherin-associated protein), alpha 2

GPM6B
11.94
1.51E−14
glycoprotein M6B

CSAG1|CSAG2|CSAG3
11.88
1.42E−15
chondrosarcoma associated gene 1|CSAG family, member 2|CSAG family, member 3

COL1A2
11.26
0.00E+00
collagen, type I, alpha 2

RCAN2
11.10
7.01E−45
regulator of calcineurin 2

MAF
10.52
2.69E−11
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

CGNL1
10.41
5.06E−26
cingulin-like 1

ARHGAP28
10.03
4.15E−29
Rho GTPase activating protein 28

MGAT4A
9.69
7.01E−45
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

WISP2
9.27
4.48E−44
WNT1 inducible signaling pathway protein 2

SULF2
9.21
4.22E−15
sulfatase 2

CBLN2
8.73
1.58E−39
cerebellin 2 precursor

CELF2
8.36
0.00E+00
CUGBP, Elav-like family member 2

QPRT
8.31
3.44E−39
quinolinate phosphoribosyltransferase

CALCA
7.63
3.89E−12
calcitonin-related polypeptide alpha

ALX4
7.62
8.08E−32
ALX homeobox 4

EPHA3
7.53
0.00E+00
EPH receptor A3

CD33
7.53
1.37E−40
CD33 molecule

TNFRSF9
7.12
0.00E+00
tumor necrosis factor receptor superfamily, member 9

KIT
6.96
7.30E−37
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

FOXO1
6.82
1.16E−14
forkhead box O1

F2RL2
6.59
4.88E−33
coagulation factor II (thrombin) receptor-like 2

ZNF229
6.58
0.000241
zinc finger protein 229

CCDC69
6.55
2.06E−28
coiled-coil domain containing 69

MEX3A
6.51
3.28E−21
mex-3 homolog A (C. elegans)

CKB
6.47
4.76E−42
creatine kinase, brain

THY1
6.30
8.38E−18
Thy-1 cell surface antigen

ABLIM1
6.12
1.62E−30
actin binding LIM protein 1

PCDH7
6.04
1.54E−29
protocadherin 7

SLC9A3R1
6.02
0.00E+00
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1

BIRC7
5.98
2.51E−17
baculoviral IAP repeat-containing 7

MEF2C
5.86
6.40E−43
myocyte enhancer factor 2C

PIK3R3
5.80
2.36E−18
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

CD24
5.61
4.33E−22
CD24 molecule

CALCB
5.58
0.00E+00
calcitonin-related polypeptide beta

UGT2B4
5.56
9.90E−13
UDP glucuronosyltransferase 2 family, polypeptide B4

SGCD
5.55
7.22E−35
sarcoglycan, delta (35 kDa dystrophin-associated glycoprotein)

DLX4
5.50
0.00E+00
distal-less homeobox 4

TP53
5.49
1.54E−28
tumor protein p53

BCL2L11
5.33
1.26E−27
BCL2-like 11 (apoptosis facilitator)

MDK
5.33
2.69E−32
midkine (neurite growth-promoting factor 2)

COL14A1
5.30
1.96E−19
collagen, type XIV, alpha 1

DPP4
5.25
8.24E−31
dipeptidyl-peptidase 4

FRMPD4
5.12
1.69E−10
FERM and PDZ domain containing 4

SORL1
5.06
5.16E−10
sortilin-related receptor, L(DLR class) A repeats-containing

RCOR2
5.02
1.79E−18
REST corepressor 2

LCP1
−4.95
1.89E−14
lymphocyte cytosolic protein 1 (L-plastin)

EPHB2
−4.99
3.43E−18
EPH receptor B2

LOC100509788 . . .
−5.04
1.15E−14
hypothetical LOC100509788|hypothetical LOC100507248

ID1
−5.06
4.56E−35
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

IL13RA2
−5.25
0.00E+00
interleukin 13 receptor, alpha 2

NAV2
−5.25
0.00E+00
neuron navigator 2

TOX2
−5.28
1.60E−37
TOX high mobility group box family member 2

HLA-DRB1 . . .
−5.30
9.97E−19
major histocompatibility complex, class II, DR beta 1 . . .

FST
−5.32
5.01E−29
follistatin

KRT15
−5.33
3.11E−35
keratin 15

CRYM
−5.40
6.12E−17
crystallin, mu

AFF3
−5.52
7.41E−14
AF4/FMR2 family, member 3

NAMPT
−5.54
0.00E+00
nicotinamide phosphoribosyltransferase

COL4A6
−5.56
1.74E−21
collagen, type IV, alpha 6

HS3ST2
−5.63
8.54E−29
heparan sulfate (glucosamine) 3-O-sulfotransferase 2

DNER
−5.92
9.79E−12
delta/notch-like EGF repeat containing

C3orf14
−5.94
4.38E−22
chromosome 3 open reading frame 14

TXNIP
−6.02
5.66E−32
thioredoxin interacting protein

IL8
−6.44
1.49E−36
interleukin 8

GALNT12
−6.73
4.86E−30
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase

12 (GalNAc-T12)

FAM133A
−6.93
4.20E−45
family with sequence similarity 133, member A

ACPP
−7.14
5.48E−32
acid phosphatase, prostate

PTX3
−7.23
1.76E−35
pentraxin 3, long

DCC
−7.24
6.16E−23
deleted in colorectal carcinoma

FARP1
−7.26
1.40E−24
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

BDKRB1
−7.27
0.00E+00
bradykinin receptor B1

TFPI2
−7.56
0.00E+00
tissue factor pathway inhibitor 2

IL1RN
−8.00
5.74E−19
interleukin 1 receptor antagonist

FOXF1
−8.20
0.00E+00
forkhead box F1

DDIT4L
−8.25
2.01E−37
DNA-damage-inducible transcript 4-like

COL13A1
−8.38
0.00E+00
collagen, type XIII, alpha 1

VAT1L
−8.62
2.06E−29
vesicle amine transport protein 1 homolog (T. californica)-like

PLAU
−9.17
4.46E−25
plasminogen activator, urokinase

BEX1
−9.73
4.20E−45
brain expressed, X-linked 1

MGC87042
−13.51
2.14E−20
STEAP family protein MGC87042

TFAP2C
−13.77
0.00E+00
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

STC1
−15.24
2.80E−45
stanniocalcin 1

SBSN
−16.74
0.00E+00
suprabasin

MMP3
−19.01
0.00E+00
matrix metallopeptidase 3 (stromelysin 1, progelatinase)

IL1B
−25.20
0.00E+00
interleukin 1, beta

MMP1
−37.04
0.00E+00
matrix metallopeptidase 1 (interstitial collagenase)

TABLE 2

Cav-1 Regulates Cancer-Associated Gene Expression. Enrichment score (ES), normalized enrichment score (NES), nominal p-value, and false

discovery rate (FDR) q-value for selected gene sets enriched in LV105 Cav-1 cells vs control using (A) gene ontology: biological process

and (B) canonical pathway molecular signature databases (n = 3 samples from each group). For a detailed list of genes see Table S1.

Gene Set
Enrichment Score (ES)
Normalized ES
Nominal p-value
FDR q-value

A. Gene ontology: Biological process

NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION
0.500
2.023
<0.001
0.092

REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_—
0.619
1.846
<0.001
0.071

BETA_RECEPTOR_PATHWAY

CASPASE_ACTIVATION
0.566
1.748
<0.001
0.067

NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY
0.521
1.537
<0.001
0.160

NEGATIVE_REGULATION_OF_CELL_PROLIFERATION
0.331
1.460
<0.001
0.190

NEGATIVE_REGULATION_OF_TRANSCRIPTION
0.340
1.367
<0.001
0.211

APOPTOSIS_GO
0.313
1.338
<0.001
0.227

POSITIVE_REGULATION_OF_CELL_ADHESION
0.501
1.308
<0.001
0.243

B. Canonical pathways

BIOCARTA_AKT_PATHWAY
0.647
1.965
<0.001
0.137

SA_PROGRAMMED_CELL_DEATH
0.739
1.923
<0.001
0.142

KEGG_ECM_RECEPTOR_INTERACTION
0.496
1.857
<0.001
0.158

KEGG_MTOR_SIGNALING_PATHWAY
0.487
1.831
<0.001
0.125

REACTOME_PI3K_AKT_SIGNALING
0.479
1.682
<0.001
0.144

REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS
0.423
1.592
<0.001
0.142

BIOCARTA_ERK_PATHWAY
0.493
1.583
<0.001
0.151

KEGG_APOPTOSIS
0.360
1.521
<0.001
0.169

SUPPLEMENTARY TABLE 1

Gene Set Enrichment Data. Expanded Gene Set Enrichment Analysis for (A) gene ontology: biological

process and (B) canonical pathway molecular signature databases (n = 3 samples from each group).

A. Gene Ontology: Biological Process

NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION

Description: Genes annotated by the GO term GO:0009968. Any process that stops,

prevents or reduces the frequency, rate or extent of signal transduction.

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.500
2.023
<0.001
0.092
0.139

PROBE
FOLD CHANGE
DESCRIPTION

THY1
8.45
Thy-1 cell surface antigen

FRZB
7.02
frizzled-related protein

OTUD7B
2.76
OTU domain containing 7B

PEG10
2.74
paternally expressed 10

NF1
2.51
neurofibromin 1

PTEN
2.16
phosphatase and tensin homolog

CBY1
2.04
chibby homolog 1 (Drosophila)

EID2
1.88
EP300 interacting inhibitor of differentiation 2

RHOH
1.86
ras homolog gene family, member H

TAX1BP3
1.57
Tax1 (human T-cell leukemia virus type I) binding protein 3

REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_PATHWAY

Description: Genes annotated by the GO term GO:0017015. Any process that modulates

the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway.

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.619
1.846
<0.001
0.071
0.227

PROBE
FOLD CHANGE
DESCRIPTION

CDKN1C
12.43
cyclin-dependent kinase inhibitor 1C (p57, Kip2)

PEG10
2.74
paternally expressed 10

SMAD4
1.92
SMAD family member 4

EID2
1.88
EP300 interacting inhibitor of differentiation 2

SMAD2
1.58
SMAD family member 2

SMAD3
1.53
SMAD family member 3

CASPASE_ACTIVATION

Description: Genes annotated by the GO term GO:0006919. Upregulation of the activity

of a caspase, any of a group of cysteine proteases involved in apoptosis.

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.566
1.748
<0.001
0.067
0.274

PROBE
FOLD CHANGE
DESCRIPTION

TP53
7.01
tumor protein p53

F2R
4.40
coagulation factor II (thrombin) receptor

CYCS
3.06
cytochrome c, somatic

MOAP1
2.76
modulator of apoptosis 1

CASP9
2.18
caspase 9, apoptosis-related cysteine peptidase

STAT1
1.55
signal transducer and activator of transcription 1, 91 kDa

SMAD3
1.53
SMAD family member 3

NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY

Description: Genes annotated by the GO term GO:0043407. Any process that stops,

prevents or reduces the frequency, rate or extent of MAP kinase activity.

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.521
1.537
<0.001
0.160
0.858

PROBE
FOLD CHANGE
DESCRIPTION

DUSP8
3.79
dual specificity phosphatase 8

DUSP9
2.70
dual specificity phosphatase 9

NF1
2.51
neurofibromin 1

GPS2
2.22
G protein pathway suppressor 2

RGS4
1.55
regulator of G-protein signaling 4

NEGATIVE_REGULATION_OF_CELL_PROLIFERATION

Description: Genes annotated by the GO term GO:0008285. Any process that

stops, prevents or reduces the rate or extent of cell proliferation.

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.331
1.460
<0.001
0.190
0.900

PROBE
FOLD CHANGE
DESCRIPTION

IFITM1
19.62
interferon induced transmembrane protein 1 (9-27)

CDKN1C
12.43
cyclin-dependent kinase inhibitor 1C (p57, Kip2)

CD33
9.90
CD33 molecule

TNFRSF8
5.42
tumor necrosis factor receptor superfamily, member 8

FABP3
4.69
fatty acid binding protein 3, muscle and heart (mammary-derived

growth inhibitor)

SESN1
4.33
sestrin 1

BTG2
3.65
BTG family, member 2

NCK2
3.51
NCK adaptor protein 2

FABP6
2.78
fatty acid binding protein 6, ileal

MXI1
2.40
MAX interactor 1

CDK6
2.31
cyclin-dependent kinase 6

ODZ1
2.27
odz, odd Oz/ten-m homolog 1(Drosophila)

VHL
2.25
von Hippel-Lindau tumor suppressor

RARRES3
2.16
retinoic acid receptor responder (tazarotene induced) 3

PTEN
2.16
phosphatase and tensin homolog

PTHLH
2.06
parathyroid hormone-like hormone

TGFB1I1
2.06
transforming growth factor beta 1 induced transcript 1

ETS1
2.03
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

GHRL
2.02
ghrelin/obestatin prepropeptide

MAGED1
1.93
melanoma antigen family D, 1

TOB1
1.88
transducer of ERBB2, 1

SSTR3
1.84
somatostatin receptor 3

WARS
1.83
tryptophanyl-tRNA synthetase

RBBP4
1.79
retinoblastoma binding protein 4

SSTR4
1.78
somatostatin receptor 4

MDM4
1.72
Mdm4 p53 binding protein homolog (mouse)

LDOC1
1.65
leucine zipper, down-regulated in cancer 1

ING5
1.64
inhibitor of growth family, member 5

SIRPG
1.64
signal-regulatory protein gamma

KLF11
1.61
Kruppel-like factor 11

ING1
1.61
inhibitor of growth family, member 1

GML
1.57
glycosylphosphatidylinositol anchored molecule like protein

CDH13
1.55
cadherin 13, H-cadherin (heart)

BAP1
1.55
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

TOB2
1.54
transducer of ERBB2, 2

FABP7
1.51
fatty acid binding protein 7, brain

PPM1D
1.50
protein phosphatase, Mg2+/Mn2+ dependent, 1D

NEGATIVE_REGULATION_OF_TRANSCRIPTION

Description: Genes annotated by the GO term GO:0016481. Any process that

stops, prevents or reduces the frequency, rate or extent of transcription.

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.340
1.367
<0.001
0.211
0.900

PROBE
FOLD CHANGE
DESCRIPTION

CALCA
11.61
calcitonin-related polypeptide alpha

FOXN3
7.06
forkhead box N3

HEXIM1
4.02
hexamethylene bis-acetamide inducible 1

HDAC5
3.87
histone deacetylase 5

POU2F1
3.53
POU class 2 homeobox 1

ARID5B
3.04
AT rich interactive domain 5B (MRF1-like)

NRG1
2.80
neuregulin 1

MYST4
2.79
MYST histone acetyltransferase (monocytic leukemia) 4

TWIST1
2.67
twist homolog 1 (Drosophila)

LANCL2
2.41
LanC lantibiotic synthetase component C-like 2 (bacterial)

VHL
2.25
von Hippel-Lindau tumor suppressor

ZHX1
2.19
zinc fingers and homeoboxes 1

MEIS2
2.07
Meis homeobox 2

CBY1
2.04
chibby homolog 1 (Drosophila)

ZBTB16
2.03
zinc finger and BTB domain containing 16

GLIS3
1.95
GLIS family zinc finger 3

RUNX2
1.93
runt-related transcription factor 2

SMAD4
1.92
SMAD family member 4

ID2
1.89
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

EID2
1.88
EP300 interacting inhibitor of differentiation 2

NDUFA13
1.86
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13

STAT3
1.84
signal transducer and activator of transcription 3 (acute-phase

response factor)

ZNF174
1.84
zinc finger protein 174

ERN2
1.83
endoplasmic reticulum to nucleus signaling 2

SMARCE1
1.80
SWI/SNF related, matrix associated, actin dependent regulator of

chromatin, subfamily e, member 1

GLIS1
1.78
GLIS family zinc finger 1

HSBP1
1.78
heat shock factor binding protein 1

UBP1
1.76
upstream binding protein 1 (LBP-1a)

TRIM27
1.74
tripartite motif-containing 27

MDM4
1.72
Mdm4 p53 binding protein homolog (mouse)

ZNF148
1.69
zinc finger protein 148

CREBZF
1.67
CREB/ATF bZIP transcription factor

SMARCC2
1.66
SWI/SNF related, matrix associated, actin dependent regulator of

chromatin, subfamily c, member 2

MEN1
1.66
multiple endocrine neoplasia I

EID1
1.66
EP300 interacting inhibitor of differentiation 1

MYST1
1.65
MYST histone acetyltransferase 1

PML
1.65
promyelocytic leukemia

HEXIM2
1.61
hexamthylene bis-acetamide inducible 2

BCLAF1
1.61
BCL2-associated transcription factor 1

KLF11
1.61
Kruppel-like factor 11

SIRT2
1.60
sirtuin 2

SMAD2
1.58
SMAD family member 2

SUMO1
1.58
SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

ZNF157
1.57
zinc finger protein 157

LDB1
1.57
LIM domain binding 1

SIN3A
1.55
SIN3 homolog A, transcription regulator (yeast)

HDAC8
1.54
histone deacetylase 8

ZEB1
1.51
zinc finger E-box binding homeobox 1

BCL3
1.49
B-cell CLL/lymphoma 3

ZNF281
1.49
zinc finger protein 281

APOPTOSIS_GO

Description: Genes annotated by the GO term GO:0006915. A form of programmed cell death.

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.313
1.338
<0.001
0.227
0.943

PROBE
FOLD CHANGE
DESCRIPTION

APOE
30.82
apolipoprotein E

DAPK1
10.17
death-associated protein kinase 1

FOXO1
8.55
forkhead box O1

TP53
7.01
tumor protein p53

BCL2L11
6.76
BCL2-like 11 (apoptosis facilitator)

SNCA
6.48
synuclein, alpha (non A4 component of amyloid precursor)

PRUNE2
6.19
prune homolog 2 (Drosophila)

PROC
5.53
protein C (inactivator of coagulation factors Va and VIIIa)

TNFRSF8
5.42
tumor necrosis factor receptor superfamily, member 8

F2R
4.40
coagulation factor II (thrombin) receptor

ACVR1C
4.08
activin A receptor, type IC

TNFSF12
3.54
tumor necrosis factor (ligand) superfamily, member 12

IGFBP3
3.51
insulin-like growth factor binding protein 3

PPP1R13B
3.42
protein phosphatase 1, regulatory (inhibitor) subunit 13B

JMY
3.38
junction mediating and regulatory protein, p53 cofactor

TNFRSF25
3.25
tumor necrosis factor receptor superfamily, member 25

PYCARD
3.08
PYD and CARD domain containing

CYCS
3.06
cytochrome c, somatic

MOAP1
2.76
modulator of apoptosis 1

ADORA1
2.67
adenosine A1 receptor

AHR
2.67
aryl hydrocarbon receptor

BAK1
2.53
BCL2-antagonist/killer 1

SOCS2
2.52
suppressor of cytokine signaling 2

DDAH2
2.51
dimethylarginine dimethylaminohydrolase 2

ASNS
2.49
asparagine synthetase (glutamine-hydrolyzing)

PDCD2
2.40
programmed cell death 2

CD70
2.32
CD70 molecule

DHCR24
2.25
24-dehydrocholesterol reductase

NUAK2
2.21
NUAK family, SNF1-like kinase, 2

CASP9
2.18
caspase 9, apoptosis-related cysteine peptidase

SGPL1
2.17
sphingosine-1-phosphate lyase 1

CASP6
2.17
caspase 6, apoptosis-related cysteine peptidase

PTEN
2.16
phosphatase and tensin homolog

BID
2.08
BH3 interacting domain death agonist

CASP3
2.06
caspase 3, apoptosis-related cysteine peptidase

AVEN
2.05
apoptosis, caspase activation inhibitor

BIRC6
2.05
baculoviral IAP repeat-containing 6

SRGN
2.04
serglycin

MX1
2.03
myxovirus (influenza virus) resistance 1, interferon-inducible protein

p78 (mouse)

PSEN1
2.02
presenilin 1

GHRL
2.02
ghrelin/obestatin prepropeptide

DNAJB6
2.02
DnaJ (Hsp40) homolog, subfamily B, member 6

BAG4
2.02
BCL2-associated athanogene 4

DOCK1
2.01
dedicator of cytokinesis 1

MAGEH1
2.01
melanoma antigen family H, 1

PCBP4
1.98
poly(rC) binding protein 4

RHOT1
1.93
ras homolog gene family, member T1

MAGED1
1.93
melanoma antigen family D, 1

BRAF
1.90
v-raf murine sarcoma viral oncogene homolog B1

NDUFA13
1.86
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13

MADD
1.85
MAP-kinase activating death domain

TRIAP1
1.85
TP53 regulated inhibitor of apoptosis 1

DYRK2
1.85
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

SH3GLB1
1.85
SH3-domain GRB2-like endophilin B1

SSTR3
1.84
somatostatin receptor 3

ERN2
1.83
endoplasmic reticulum to nucleus signaling 2

NDUFS3
1.79
NADH dehydrogenase (ubiquinone) Fe—S protein 3, 30 kDa (NADH-

coenzyme Q reductase)

ERCC3
1.79
excision repair cross-complementing rodent repair deficiency,

complementation group 3 (xeroderma pigmentosum group B

complementing)

DNM1L
1.77
dynamin 1-like

MAPK8
1.76
mitogen-activated protein kinase 8

BCL2L2
1.76
BCL2-like 2

CRADD
1.75
CASP2 and RIPK1 domain containing adaptor with death domain

SMNDC1
1.74
survival motor neuron domain containing 1

RNF7
1.73
ring finger protein 7

MDM4
1.72
Mdm4 p53 binding protein homolog (mouse)

BECN1
1.71
beclin 1, autophagy related

VDAC1
1.71
voltage-dependent anion channel 1

ZNF346
1.69
zinc finger protein 346

BAG1
1.69
BCL2-associated athanogene

FIS1
1.67
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)

HSPA9
1.66
heat shock 70 kDa protein 9 (mortalin)

TRAF7
1.65
TNF receptor-associated factor 7

PML
1.65
promyelocytic leukemia

ABL1
1.63
c-abl oncogene 1, non-receptor tyrosine kinase

UTP11L
1.63
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)

RTKN
1.62
rhotekin

BRE
1.61
brain and reproductive organ-expressed (TNFRSF1A modulator)

BCLAF1
1.61
BCL2-associated transcription factor 1

AIFM2
1.60
apoptosis-inducing factor, mitochondrion-associated, 2

ANXA4
1.60
Annexin A4

PDCD6
1.60
programmed cell death 6

SRA1
1.60
steroid receptor RNA activator 1

RIPK1
1.57
receptor (TNFRSF)-interacting serine-threonine kinase 1

NFKB1
1.57
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

STK3
1.57
serine/threonine kinase 3

GML
1.57
glycosylphosphatidylinositol anchored molecule like protein

AIFM1
1.57
apoptosis-inducing factor, mitochondrion-associated, 1

FOXL2
1.57
forkhead box L2

TXNL1
1.56
thioredoxin-like 1

STAT1
1.55
signal transducer and activator of transcription 1, 91 kDa

MRPS30
1.55
mitochondrial ribosomal protein S30

CDH13
1.55
cadherin 13, H-cadherin (heart)

SON
1.55
SON DNA binding protein

CIAPIN1
1.53
cytokine induced apoptosis inhibitor 1

STK17B
1.52
serine/threonine kinase 17b

ACIN1
1.51
apoptotic chromatin condensation inducer 1

TSPO
1.50
translocator protein (18 kDa)

TAX1BP1
1.50
Tax1 (human T-cell leukemia virus type I) binding protein 1

BCL3
1.49
B-cell CLL/lymphoma 3

POSITIVE_REGULATION_OF_CELL_ADHESION

Description: Genes annotated by the GO term GO:0045785. Any process that

activates or increases the frequency, rate or extent of cell adhesion.

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.501
1.308
<0.001
0.243
0.943

PROBE
FOLD CHANGE
DESCRIPTION

CDK6
2.31
cyclin-dependent kinase 6

SAA1
2.17
serum amyloid A1

SIRPG
1.64
signal-regulatory protein gamma

CDH13
1.55
cadherin 13, H-cadherin (heart)

B. Canonical Pathways

BIOCARTA_AKT_PATHWAY

Description: AKT Signaling Pathway

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.647
1.965
<0.001
0.137
0.167

PROBE
FOLD CHANGE
DESCRIPTION

GHR
16.06
growth hormone receptor

FOXO1
8.55
forkhead box O1

CASP9
2.18
caspase 9, apoptosis-related cysteine peptidase

CHUK
1.65
conserved helix-loop-helix ubiquitous kinase

NFKB1
1.57
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

IKBKB
1.54
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase

beta

SA_PROGRAMMED_CELL_DEATH

Description: Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.739
1.923
<0.001
0.142
0.261

PROBE
FOLD CHANGE
DESCRIPTION

BCL2L11
6.76
BCL2-like 11 (apoptosis facilitator)

BAK1
2.53
BCL2-antagonist/killer 1

CASP9
2.18
caspase 9, apoptosis-related cysteine peptidase

BID
2.08
BH3 interacting domain death agonist

KEGG_ECM_RECEPTOR_INTERACTION

Description: ECM-receptor interaction

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.496
1.857
<0.001
0.158
0.362

PROBE
FOLD CHANGE
DESCRIPTION

COL3A1
189.00
collagen, type III, alpha 1

COL4A1
38.67
collagen, type IV, alpha 1

COL1A2
14.75
collagen, type I, alpha 2

ITGB8
6.07
integrin, beta 8

COL5A2
5.95
collagen, type V, alpha 2

ITGA10
4.84
integrin, alpha 10

COL1A1
4.44
collagen, type I, alpha 1

RELN
3.89
reelin

COL4A2
3.70
collagen, type IV, alpha 2

THBS3
3.12
thrombospondin 3

ITGA4
3.06
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

THBS4
3.01
thrombospondin 4

SDC2
2.87
syndecan 2

ITGAV
2.56
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen

CD51)

ITGB6
2.49
integrin, beta 6

COL5A1
2.47
collagen, type V, alpha 1

ITGA6
2.15
integrin, alpha 6

LAMA5
1.96
laminin, alpha 5

DAG1
1.81
dystroglycan 1 (dystrophin-associated glycoprotein 1)

ITGB5
1.71
integrin, beta 5

LAMB1
1.69
laminin, beta 1

AGRN
1.64
agrin

KEGG_MTOR_SIGNALING_PATHWAY

Description: mTOR signaling pathway

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.487
1.831
<0.001
0.125
0.362

PROBE
FOLD CHANGE
DESCRIPTION

IGF1
13.36
insulin-like growth factor 1 (somatomedin C)

PIK3R3
7.27
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

AKT2
3.13
v-akt murine thymoma viral oncogene homolog 2

ULK1
2.79
unc-51-like kinase 1 (C. elegans)

RPS6KA1
2.70
ribosomal protein S6 kinase, 90 kDa, polypeptide 1

RPS6KA3
2.62
ribosomal protein S6 kinase, 90 kDa, polypeptide 3

EIF4B
2.35
eukaryotic translation initiation factor 4B

STK11
2.31
serine/threonine kinase 11

EIF4E2
2.01
eukaryotic translation initiation factor 4E family member 2

BRAF
1.90
v-raf murine sarcoma viral oncogene homolog B1

MTOR
1.54
mechanistic target of rapamycin (serine/threonine kinase)

REACTOME_PI3K_AKT_SIGNALING

Description: Genes involved in PI3K/AKT signalling

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.479
1.682
<0.001
0.144
0.452

PROBE
FOLD CHANGE
DESCRIPTION

FOXO1
8.55
forkhead box O1

AKT2
3.13
v-akt murine thymoma viral oncogene homolog 2

IRS1
2.43
insulin receptor substrate 1

CASP9
2.18
caspase 9, apoptosis-related cysteine peptidase

PTEN
2.16
phosphatase and tensin homolog

TRIB3
1.84
tribbles homolog 3 (Drosophila)

CHUK
1.65
conserved helix-loop-helix ubiquitous kinase

MTOR
1.54
mechanistic target of rapamycin (serine/threonine kinase)

CREB1
1.52
cAMP responsive element binding protein 1

REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

Description: Genes involved in Integrin cell surface interactions

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.423
1.592
<0.001
0.142
0.759

PROBE
FOLD CHANGE
DESCRIPTION

COL4A1
38.67
collagen, type IV, alpha 1

COL1A2
14.75
collagen, type I, alpha 2

ITGB8
6.07
integrin, beta 8

ICAM2
5.58
intercellular adhesion molecule 2

ITGA10
4.84
integrin, alpha 10

COL1A1
4.44
collagen, type I, alpha 1

COL4A2
3.70
collagen, type IV, alpha 2

ITGA4
3.06
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

ITGAV
2.56
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen

CD51)

SRC
2.53
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

ITGB6
2.49
integrin, beta 6

MADCAM1
2.19
mucosal vascular addressin cell adhesion molecule 1

ITGA6
2.15
integrin, alpha 6

LAMA5
1.96
laminin, alpha 5

SOS1
1.84
son of sevenless homolog 1 (Drosophila)

ITGB5
1.71
integrin, beta 5

LAMB1
1.69
laminin, beta 1

RAPGEF3
1.65
Rap guanine nucleotide exchange factor (GEF) 3

ITGAL
1.65
integrin, alpha L (antigen CD11A (p180), lymphocyte function-

associated antigen 1; alpha polypeptide)

BIOCARTA_ERK_PATHWAY

Description: Erk1/Erk2 Mapk Signaling pathway

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.493
1.583
<0.001
0.151
0.759

PROBE
FOLD CHANGE
DESCRIPTION

NGFR
10.07
nerve growth factor receptor

PDGFRA
7.22
platelet-derived growth factor receptor, alpha polypeptide

RPS6KA1
2.70
ribosomal protein S6 kinase, 90 kDa, polypeptide 1

SRC
2.53
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

MKNK2
2.26
MAP kinase interacting serine/threonine kinase 2

MKNK1
2.24
MAP kinase interacting serine/threonine kinase 1

STAT3
1.84
signal transducer and activator of transcription 3 (acute-phase

response factor)

SOS1
1.84
son of sevenless homolog 1 (Drosophila)

GNAS
1.82
GNAS complex locus

SHC1
1.74
SHC (Src homology 2 domain containing) transforming protein 1

RPS6KA5
1.71
ribosomal protein S6 kinase, 90 kDa, polypeptide 5

KEGG_APOPTOSIS

Description: Apoptosis

Enrichment
Normalized

Score (ES)
ES
Nominal p-value
FDR q-value
FWER p-value

0.360
1.521
<0.001
0.169
0.804

PROBE
FOLD CHANGE
DESCRIPTION

PIK3R3
7.27
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

TP53
7.01
tumor protein p53

AKT2
3.13
v-akt murine thymoma viral oncogene homolog 2

CYCS
3.06
cytochrome c, somatic

PRKACB
2.79
protein kinase, cAMP-dependent, catalytic, beta

CASP9
2.18
caspase 9, apoptosis-related cysteine peptidase

CASP6
2.17
caspase 6, apoptosis-related cysteine peptidase

BID
2.08
BH3 interacting domain death agonist

CASP3
2.06
caspase 3, apoptosis-related cysteine peptidase

PPP3CA
1.98
protein phosphatase 3, catalytic subunit, alpha isozyme

CHP
1.78
calcium binding protein P22

MYD88
1.75
myeloid differentiation primary response gene (88)

ENDOD1
1.68
endonuclease domain containing 1

CHUK
1.65
conserved helix-loop-helix ubiquitous kinase

RIPK1
1.57
receptor (TNFRSF)-interacting serine-threonine kinase 1

NFKB1
1.57
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

AIFM1
1.57
apoptosis-inducing factor, mitochondrion-associated, 1

IKBKB
1.54
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase

beta

PRKACA
1.51
protein kinase, cAMP-dependent, catalytic, alpha

Probe ID
Gene_symbol
Description
Fold Change
p-value
Entrez_gene

PH_hs_0004751
MMP1
matrix metallopeptidase 1 (interstitial collagenase)
−37.04
0.000E+00
4312

PH_hs_0007166
IL1B
interleukin 1, beta
−25.20
0.000E+00
3553

PH_hs_0024245
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
−19.01
0.000E+00
4314

PH_hs_0020125
SBSN
suprabasin
−16.74
0.000E+00
374897

PH_hs_0002254
STC1
stanniocalcin 1
−15.24
2.803E−45
6781

PH_hs_0020945
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
−13.77
0.000E+00
7022

PH_hs_0036700
MGC87042
STEAP family protein MGC87042
−13.51
2.139E−20
256227

PH_hs_0016413
BEX1
brain expressed, X-linked 1
−9.73
4.204E−45
55859

PH_hs_0031336
PLAU
plasminogen activator, urokinase
−9.17
4.462E−25
5328

PH_hs_0002016
VAT1L
vesicle amine transport protein 1 homolog (T. californica)-like
−8.62
2.057E−29
57687

PH_hs_0012290
COL13A1
collagen, type XIII, alpha 1
−8.38
0.000E+00
1305

PH_hs_0005972
DDIT4L
DNA-damage-inducible transcript 4-like
−8.25
2.013E−37
115265

PH_hs_0009376
FOXF1
forkhead box F1
−8.20
0.000E+00
2294

PH_hs_0004656
IL1RN
interleukin 1 receptor antagonist
−8.00
5.741E−19
3557

PH_hs_0025658
TFPI2
tissue factor pathway inhibitor 2
−7.56
0.000E+00
7980

PH_hs_0003282
BDKRB1
bradykinin receptor B1
−7.27
0.000E+00
623

PH_hs_0032166
FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
−7.26
1.402E−24
10160

PH_hs_0048377
DCC
deleted in colorectal carcinoma
−7.24
6.156E−23
1630

PH_hs_0000274
PTX3
pentraxin 3, long
−7.23
1.757E−35
5806

PH_hs_0024475
ACPP
acid phosphatase, prostate
−7.14
5.483E−32
55

PH_hs_0006070
FAM133A
family with sequence similarity 133, member A
−6.93
4.204E−45
286499

PH_hs_0003348
GALNT12
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
−6.73
4.860E−30
79695

PH_hs_0000069
1L8
interleukin 8
−6.44
1.489E−36
3576

PH_hs_0010634
TXNIP
thioredoxin interacting protein
−6.02
5.663E−32
10628

PH_hs_0003353
C3orf14
chromosome 3 open reading frame 14
−5.94
4.380E−22
57415

PH_hs_0012787
DNER
delta/notch-like EGF repeat containing
−5.92
9.790E−12
92737

PH_hs_0006337
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
−5.63
8.543E−29
9956

PH_hs_0000049
COL4A6
collagen, type IV, alpha 6
−5.56
1.738E−21
1288

PH_hs_0043284
NAMPT
nicotinamide phosphoribosyltransferase
−5.54
0.000E+00
10135

PH_hs_0049129
AFF3
AF4/FMR2 family, member 3
−5.52
7.406E−14
3899

PH_hs_0000116
CRYM
crystallin, mu
−5.40
6.122E−17
1428

PH_hs_0004626
KRT15
keratin 15
−5.33
3.109E−35
3866

PH_hs_0044664
FST
follistatin
−5.32
5.014E−29
10468

PH_hs_0028155
HLA-DRB1|HLA-
major histocompatibility complex, class II, DR beta 1|major histocompatibility complex, class II, DR beta 3|HLA class II
−5.30
9.970E−19
3123|3125|1002

DRB3|LOC1002909
histocompatibility antigen, DRB1-13 beta chain-like|HLA class II histocompatibility antigen, DR beta 3 chain-like|HLA class

90966|10051049

66|LOC100510495|L
II histocompatibility antigen, DRB1-3 chain-like|HLA class II histocompatibility antigen, DR beta 3 chain-like

5|100294276|10

OC100294276|LOC

0510687

100510687

PH_hs_0002348
TOX2
TOX high mobility group box family member 2
−5.28
1.597E−37
84969

PH_hs_0046213
NAV2
neuron navigator 2
−5.25
0.000E+00
89797

PH_hs_0023876
IL13RA2
interleukin 13 receptor, alpha 2
−5.25
0.000E+00
3598

PH_hs_0024850
ID1
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
−5.06
4.560E−35
3397

PH_hs_0012929
LOC100509788|LO
hypothetical LOC100509788|hypothetical LOC100507248
−5.04
1.146E−14
100509788|1005

C100507248

07248

PH_hs_0007059
EPHB2
EPH receptor B2
−4.99
3.432E−18
2048

PH_hs_0018575
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
−4.95
1.889E−14
3936

PH_hs_0019600
KCNS3
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
−4.95
4.978E−11
3790

PH_hs_0046498
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
−4.82
1.368E−34
3127

PH_hs_0045183
ZNF542
zinc finger protein 542
−4.81
4.141E−04
147947

PH_hs_0014393
TRPV2
transient receptor potential cation channel, subfamily V, member 2
−4.75
1.016E−28
51393

PH_hs_0043843
AK4
adenylate kinase 4
−4.73
1.111E−08
205

PH_hs_0024184
CCND1
cyclin D1
−4.73
2.278E−30
595

PH_hs_0001350
SMOC1
SPARC related modular calcium binding 1
−4.70
9.249E−44
64093

PH_hs_0030595
CLDN14
claudin 14
−4.60
9.133E−14
23562

PH_hs_0048613
EPAS1
endothelial PAS domain protein 1
−4.59
5.806E−15
2034

PH_hs_0031957
SH2D5
SH2 domain containing 5
−4.48
0.000E+00
400745

PH_hs_0043853
CDCA7L
cell division cycle associated 7-like
−4.43
3.584E−39
55536

PH_hs_0025481
HOXB7
homeobox B7
−4.41
1.473E−30
3217

PH_hs_0003918
STEAP1
six transmembrane epithelial antigen of the prostate 1
−4.39
5.290E−23
26872

PH_hs_0047837
MARCH4
membrane-associated ring finger (C3HC4) 4
−4.36
4.245E−03
57574

PH_hs_0011595
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
−4.29
1.995E−13
5743

PH_hs_0022271
LTBP2
latent transforming growth factor beta binding protein 2
−4.19
1.999E−14
4053

PH_hs_0024711
SPINK1
serine peptidase inhibitor, Kazal type 1
−4.17
2.325E−03
6690

PH_hs_0000694
RND3
Rho family GTPase 3
−4.17
1.005E−11
390

PH_hs_0048830
DSG2
desmoglein 2
−4.08
1.174E−28
1829

PH_hs_0048643
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
−4.04
1.557E−08
26011

PH_hs_0028383
NMU
neuromedin U
−4.03
1.770E−05
10874

PH_hs_0009260
NT5E
5′-nucleotidase, ecto (CD73)
−4.01
5.626E−19
4907

PH_hs_0045633
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
−4.00
7.332E−28
3082

PH_hs_0001558
DHRS3
dehydrogenase/reductase (SDR family) member 3
−3.96
8.375E−28
9249

PH_hs_0005777
RAGE
renal tumor antigen
−3.94
2.330E−26
5891

PH_hs_0030089
HLA-DRA
major histocompatibility complex, class II, DR alpha
−3.93
8.182E−28
3122

PH_hs_0034480
HLA-
major histocompatibility complex, class II, DR beta 1|HLA class II histocompatibility antigen, DRB1-13 beta chain-like|HLA
−3.92
1.174E−30
3123|100290966

DRB1|LOC1002909
class II histocompatibility antigen, DRB1-3 chain-like|major histocompatibility complex, class II, DR beta 3|HLA class II

|100294276|312

66|LOC100294276|
histocompatibility antigen, DR beta 3 chain-like|HLA class II histocompatibility antigen, DR beta 3 chain-like|HLA class II

5|100510495|10

HLA-
histocompatibility antigen, DRB1-9 beta chain-like|HLA class II histocompatibility antigen, DRB1-7 beta chain-like|HLA

0510687|100294

DRB3|LOC1005104
class II histocompatibility antigen, DRB1-7 beta chain-like|HLA class II histocompatibility antigen, DRB1-9 beta chain-

468|100507714|

95|LOC100510687|L
like|major histocompatibility complex, class II, DR beta 4|HLA class II histocompatibility antigen, DR beta 4 chain-like|HLA

100507709|1002

OC100294468|LOC
class II histocompatibility antigen, DR beta 4 chain-like|HLA class II histocompatibility antigen, DR beta 4 chain-like

94036|3126|100

100507714|LOC100

510519|1005095

507709|LOC100294

82|100509301

036|HLA-

DRB4|LOC1005105

19|LOC100509582|L

OC100509301

PH_hs_0047929
KLHL29
kelch-like 29 (Drosophila)
−3.89
1.231E−25
114818

PH_hs_0003691
CDH18
cadherin 18, type 2
−3.77
1.171E−19
1016

PH_hs_0042825
RFX8
regulatory factor X, 8
−3.75
4.197E−10
731220

PH_hs_0009039
FAM196A
family with sequence similarity 196, member A
−3.73
3.004E−15
642938

PH_hs_0030443
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
−3.72
3.420E−17
5069

PH_hs_0049346
APLN
apelin
−3.71
2.559E−26
8862

PH_hs_0046081
MEG3
maternally expressed 3 (non-protein coding)
−3.70
6.844E−10
55384

PH_hs_0047648
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
−3.66
1.152E−07
55103

PH_hs_0033958
MYO1D
myosin ID
−3.59
2.503E−14
4642

PH_hs_0023142
RRM2
ribonucleotide reductase M2
−3.55
1.203E−26
6241

PH_hs_0024642
NPC1
Niemann-Pick disease, type C1
−3.51
1.057E−14
4864

PH_hs_0004482
MTSS1
metastasis suppressor 1
−3.51
4.583E−20
9788

PH_hs_0047208
TIAM1
T-cell lymphoma invasion and metastasis 1
−3.49
1.613E−04
7074

PH_hs_0048955
LSAMP
limbic system-associated membrane protein
−3.46
3.920E−29
4045

PH_hs_0035899
TMTC1
transmembrane and tetratricopeptide repeat containing 1
−3.45
7.324E−25
83857

PH_hs_0048963
KCTD12
potassium channel tetramerisation domain containing 12
−3.43
3.396E−29
115207

PH_hs_0045043
ZAK
sterile alpha motif and leucine zipper containing kinase AZK
−3.40
4.328E−17
51776

PH_hs_0043556
HMGA1
high mobility group AT-hook 1
−3.39
2.623E−22
3159

PH_hs_0026117
TIMP1
TIMP metallopeptidase inhibitor 1
−3.38
3.742E−24
7076

PH_hs_0042141
SPA17
sperm autoantigenic protein 17
−3.37
3.888E−12
53340

PH_hs_0045771
LTBP1
latent transforming growth factor beta binding protein 1
−3.37
1.411E−30
4052

PH_hs_0028680
SPP1
secreted phosphoprotein 1
−3.36
2.569E−40
6696

PH_hs_0044741
PLAUR
plasminogen activator, urokinase receptor
−3.35
1.082E−22
5329

PH_hs_0033515
ACOX2
acyl-CoA oxidase 2, branched chain
−3.34
3.621E−18
8309

PH_hs_0048917
MAST4
microtubule associated serine/threonine kinase family member 4
−3.32
2.941E−15
375449

PH_hs_0019975
G0S2
G0/G1switch 2
−3.31
1.569E−21
50486

PH_hs_0018587
ATL3
atlastin GTPase 3
−3.29
7.670E−06
25923

PH_hs_0044542
MAPKAP1
mitogen-activated protein kinase associated protein 1
−3.26
3.340E−11
79109

PH_hs_0023338
LAMA1
laminin, alpha 1
−3.25
1.069E−14
284217

PH_hs_0040322
IL1F5
interleukin 1 family, member 5 (delta)
−3.25
4.701E−10
26525

PH_hs_0025294
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
−3.23
8.373E−06
1917

PH_hs_0022250
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
−3.21
4.649E−13
7035

PH_hs_0004525
JUN
jun proto-oncogene
−3.19
4.458E−30
3725

PH_hs_0011503
GPRC5A
G protein-coupled receptor, family C, group 5, member A
−3.18
1.116E−08
9052

PH_hs_0048091
RUNDC3B
RUN domain containing 3B
−3.18
2.274E−12
154661

PH_hs_0042114
SVIP
small VCP/p97-interacting protein
−3.17
2.297E−19
258010

PH_hs_0020544
BACE2
beta-site APP-cleaving enzyme 2
−3.15
9.307E−18
25825

PH_hs_0043471
TMEM98
transmembrane protein 98
−3.13
1.548E−07
26022

PH_hs_0000235
ILIA
interleukin 1, alpha
−3.08
1.086E−14
3552

PH_hs_0000061
ISL1
ISL LIM homeobox 1
−3.06
4.290E−05
3670

PH_hs_0028200
CENPI
centromere protein I
−3.06
1.299E−06
2491

PH_hs_0014153
TUBB6
tubulin, beta 6
−3.05
1.029E−14
84617

PH_hs_0048021
GINS4
GINS complex subunit 4 (Sld5 homolog)
−3.01
8.775E−19
84296

PH_hs_0000309
VSNL1
visinin-like 1
−2.97
3.279E−11
7447

PH_hs_0019257
AOX1
aldehyde oxidase 1
−2.92
7.321E−24
316

PH_hs_0016443
CDK1
cyclin-dependent kinase 1
−2.89
1.172E−13
983

PH_hs_0048433
GALNT9
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
−2.86
1.302E−03
50614

PH_hs_0046169
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
−2.86
1.966E−19
79674

PH_hs_0047588
SPATS2L
spermatogenesis associated, serine-rich 2-like
−2.85
9.378E−11
26010

PH_hs_0003250
CPEB2
cytoplasmic polyadenylation element binding protein 2
−2.85
6.360E−14
132864

PH_hs_0022243
SLC43A3
solute carrier family 43, member 3
−2.84
2.557E−08
29015

PH_hs_0049493
AKAP2|PALM2-
A kinase (PRKA) anchor protein 2|PALM2-AKAP2 readthrough
−2.84
6.170E−08
11217|445815

AKAP2

PH_hs_0029612
FOSL1
FOS-like antigen 1
−2.82
4.720E−03
8061

PH_hs_0001652
SPRY2
sprouty homolog 2 (Drosophila)
−2.79
1.427E−07
10253

PH_hs_0031712
DKK3
dickkopf homolog 3 (Xenopus laevis)
−2.79
4.059E−12
27122

PH_hs_0045179
SMTN
smoothelin
−2.78
7.772E−13
6525

PH_hs_0003694
HAS1
hyaluronan synthase 1
−2.77
2.110E−17
3036

PH_hs_0030777
PTTG3P|PTTG1|PT
pituitary tumor-transforming 3 (pseudogene)|pituitary tumor-transforming 1[pituitary tumor-transforming 2
−2.77
2.922E−12
26255|9232|107

TG2

44

PH_hs_0004390
IER3
immediate early response 3
−2.76
3.726E−17
8870

PH_hs_0033310
HDHD1
haloacid dehalogenase-like hydrolase domain containing 1
−2.76
1.556E−15
8226

PH_hs_0042294
C16orf42
chromosome 16 open reading frame 42
−2.75
1.576E−18
115939

PH_hs_0048024
UBASH3B
ubiquitin associated and SH3 domain containing B
−2.75
3.406E−04
84959

PH_hs_0048924
PRKCE
protein kinase C, epsilon
−2.73
3.275E−08
5581

PH_hs_0004761
GNG11
guanine nucleotide binding protein (G protein), gamma 11
−2.69
1.688E−10
2791

PH_hs_0043388
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
−2.67
1.248E−09
55304

PH_hs_0005822
HJURP
Holliday junction recognition protein
−2.66
2.269E−05
55355

PH_hs_0004404
BRP44
brain protein 44
−2.66
6.919E−16
25874

PH_hs_0004222
FAH
fumarylacetoacetate hydrolase (fumarylacetoacetase)
−2.64
4.634E−20
2184

PH_hs_0029022
CLEC2B
C-type lectin domain family 2, member B
−2.63
1.767E−15
9976

PH_hs_0045651
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
−2.62
2.055E−12
3838

PH_hs_0046334
C14orf80
chromosome 14 open reading frame 80
−2.60
5.543E−11
283643

PH_hs_0015628
FZD8
frizzled homolog 8 (Drosophila)
−2.59
1.161E−24
8325

PH_hs_0049449
GPR39
G protein-coupled receptor 39
−2.59
2.531E−16
2863

PH_hs_0010276
DUSP1
dual specificity phosphatase 1
−2.59
2.180E−20
1843

PH_hs_0027327
CTPS
CTP synthase
−2.59
4.106E−16
1503

PH_hs_0035997
PVRL3
poliovirus receptor-related 3
−2.59
6.413E−15
25945

PH_hs_0003012
FJX1
four jointed box 1 (Drosophila)
−2.59
6.317E−05
24147

PH_hs_0049442
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
−2.59
9.266E−06
57522

PH_hs_0047372
PCDHB16
protocadherin beta 16
−2.58
5.863E−11
57717

PH_hs_0025406
SQRDL
sulfide quinone reductase-like (yeast)
−2.57
8.690E−12
58472

PH_hs_0032595
CD44
CD44 molecule (Indian blood group)
−2.57
1.850E−15
960

PH_hs_0015371
MLPH
melanophilin
−2.57
2.150E−21
79083

PH_hs_0003937
ANLN
anillin, actin binding protein
−2.57
3.082E−04
54443

PH_hs_0000094
HBEGF
heparin-binding EGF-like growth factor
−2.56
1.226E−14
1839

PH_hs_0011672
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
−2.56
8.003E−09
55450

PH_hs_0024092
ZIC2
Zic family member 2 (odd-paired homolog, Drosophila)
−2.56
7.400E−07
7546

PH_hs_0024602
CNIH3
cornichon homolog 3 (Drosophila)
−2.55
7.390E−08
149111

PH_hs_0033695
EEF1A1P9
eukaryotic translation elongation factor 1 alpha 1 pseudogene 9
−2.55
6.865E−10
441032

PH_hs_0004464
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
−2.54
5.797E−09
5577

PH_hs_0047795
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
−2.52
1.053E−09
11174

PH_hs_0000277
VDR
vitamin D (1,25-dihydroxyvitamin D3) receptor
−2.52
1.733E−16
7421

PH_hs_0029239
VWA5A
von Willebrand factor A domain containing 5A
−2.48
2.493E−11
4013

PH_hs_0047888
SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
−2.48
2.500E−15
55117

PH_hs_0000691
KIAA1644
KIAA1644
−2.47
5.986E−10
85352

PH_hs_0010370
AMPH
amphiphysin
−2.47
1.200E−13
273

PH_hs_0000198
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
−2.46
4.216E−13
3053

PH_hs_0016332
FXYD5
FXYD domain containing ion transport regulator 5
−2.46
2.891E−17
53827

PH_hs_0004309
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
−2.46
2.935E−04
6567

PH_hs_0002224
RNASEH2A
ribonuclease H2, subunit A
−2.45
2.694E−09
10535

PH_hs_0002700
OSGIN1
oxidative stress induced growth inhibitor 1
−2.45
1.973E−08
29948

PH_hs_0043945
SVIL
supervillin
−2.44
9.094E−05
6840

PH_hs_0047542
GCLM
glutamate-cysteine ligase, modifier subunit
−2.44
8.375E−05
2730

PH_hs_0025078
DUSP4
dual specificity phosphatase 4
−2.44
4.669E−11
1846

PH_hs_0004975
ERCC6L
excision repair cross-complementing rodent repair deficiency, complementation group 6-like
−2.44
5.934E−03
54821

PH_hs_0001751
MAMLD1
mastermind-like domain containing 1
−2.43
3.018E−15
10046

PH_hs_0044594
UBE2C
ubiquitin-conjugating enzyme E2C
−2.42
8.370E−07
11065

PH_hs_0004080
SPHK1
sphingosine kinase 1
−2.42
4.606E−06
8877

PH_hs_0048946
QKI
quaking homolog, KH domain RNA binding (mouse)
−2.41
5.859E−18
9444

PH_hs_0019754
SPC25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
−2.41
1.395E−07
57405

PH_hs_0024110
RAB36
RAB36, member RAS oncogene family
−2.40
9.658E−11
9609

PH_hs_0010858
MELK
maternal embryonic leucine zipper kinase
−2.40
6.167E−15
9833

PH_hs_0047385
SGOL1
shugoshin-like 1 (S. pombe)
−2.39
9.663E−07
151648

PH_hs_0018565
CARS2
cysteinyl-tRNA synthetase 2, mitochondrial (putative)
−2.39
1.167E−18
79587

PH_hs_0043450
TMEM233
transmembrane protein 233
−2.39
1.186E−17
387890

PH_hs_0038499
TMEM14B
transmembrane protein 14B
−2.39
1.940E−03
81853

PH_hs_0004787
CDKN3
cyclin-dependent kinase inhibitor 3
−2.38
1.403E−15
1033

PH_hs_0043158
BASP1
brain abundant, membrane attached signal protein 1
−2.38
1.695E−12
10409

PH_hs_0043350
GSTO1
glutathione S-transferase omega 1
−2.38
1.213E−11
9446

PH_hs_0047240
RPS6KA2
ribosomal protein S6 kinase, 90 kDa, polypeptide 2
−2.38
3.127E−04
6196

PH_hs_0023540
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
−2.38
9.062E−08
2114

PH_hs_0009576
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
−2.38
3.015E−12
23057

PH_hs_0002026
BET1
blocked early in transport 1 homolog (S. cerevisiae)
−2.37
9.314E−10
10282

PH_hs_0026679
FOXM1
forkhead box M1
−2.37
5.575E−04
2305

PH_hs_0022545
SFXN1
sideroflexin 1
−2.37
1.949E−15
94081

PH_hs_0018161
ANKRD29
ankyrin repeat domain 29
−2.35
4.278E−06
147463

PH_hs_0029732
NDRG1
N-myc downstream regulated 1
−2.35
1.520E−10
10397

PH_hs_0045036
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
−2.34
7.504E−20
10060

PH_hs_0033215
TM4SF19
transmembrane 4 L six family member 19
−2.34
6.058E−10
116211

PH_hs_0033475
AHNAK2
AHNAK nucleoprotein 2
−2.33
8.839E−03
113146

PH_hs_0010770
ABHD11
abhydrolase domain containing 11
−2.33
6.707E−09
83451

PH_hs_0045849
TPBG
trophoblast glycoprotein
−2.33
5.527E−07
7162

PH_hs_0034496
PTTG3P
pituitary tumor-transforming 3 (pseudogene)
−2.33
1.490E−08
26255

PH_hs_0047831
BMP2
bone morphogenetic protein 2
−2.31
1.266E−05
650

PH_hs_0043263
CXCL2
chemokine (C-X-C motif) ligand 2
−2.31
5.565E−17
2920

PH_hs_0031701
GRB10
growth factor receptor-bound protein 10
−2.31
1.756E−22
2887

PH_hs_0000530
UBE2T
ubiquitin-conjugating enzyme E2T (putative)
−2.30
6.299E−15
29089

PH_hs_0042493
FOXH1
forkhead box H1
−2.30
5.361E−10
8928

PH_hs_0028179
CALM3
calmodulin 3 (phosphorylase kinase, delta)
−2.30
2.881E−06
808

PH_hs_0047872
LMNB2
lamin B2
−2.28
2.423E−07
84823

PH_hs_0048360
ARL4C
ADP-ribosylation factor-like 4C
−2.28
1.560E−11
10123

PH_hs_0009230
ESPL1
extra spindle pole bodies homolog 1 (S. cerevisiae)
−2.28
9.375E−05
9700

PH_hs_0029660
AKR1C1|AKR1C2|A
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid
−2.28
1.460E−04
1645|1646|8644|

KR1C3|LOC100508
dehydrogenase)|aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha

100508006|1109

006|AKR1C4
hydroxysteroid dehydrogenase, type III)|aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase,

type II)|aldo-keto reductase family 1 member C2-like|aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-

alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

PH_hs_0013082
ANKRD36BP1
ankyrin repeat domain 36B pseudogene 1
−2.27
3.058E−10
84832

PH_hs_0002592
C21orf63
chromosome 21 open reading frame 63
−2.27
8.729E−12
59271

PH_hs_0031635
ARPC5
actin related protein 2/3 complex, subunit 5, 16 kDa
−2.27
2.376E−06
10092

PH_hs_0013738
XRN2
5′-3′ exoribonuclease 2
−2.26
5.621E−07
22803

PH_hs_0049138
KIAA1462
KIAA1462
−2.26
4.763E−05
57608

PH_hs_0018468
CHN1
chimerin (chimaerin) 1
−2.26
5.839E−04
1123

PH_hs_0000776
ETHE1
ethylmalonic encephalopathy 1
−2.26
8.624E−13
23474

PH_hs_0049591
CKS1B
CDC28 protein kinase regulatory subunit 1B
−2.25
2.768E−07
1163

PH_hs_0048832
PCLO
piccolo (presynaptic cytomatrix protein)
−2.23
2.646E−15
27445

PH_hs_0028012
C1orf159
chromosome 1 open reading frame 159
−2.23
7.672E−07
54991

PH_hs_0048019
RNF157
ring finger protein 157
−2.22
9.246E−04
114804

PH_hs_0011490
C1orf94
chromosome 1 open reading frame 94
−2.22
6.699E−07
84970

PH_hs_0002603
GFPT2
glutamine-fructose-6-phosphate transaminase 2
−2.22
2.939E−12
9945

PH_hs_0003818
POC1A
POC1 centriolar protein homolog A (Chlamydomonas)
−2.21
1.470E−14
25886

PH_hs_0028708
SOX9
SRY (sex determining region Y)-box 9
−2.21
1.279E−06
6662

PH_hs_0033207
MGLL
monoglyceride lipase
−2.21
2.492E−08
11343

PH_hs_0045266
PCDHGC3
protocadherin gamma subfamily C, 3
−2.20
2.332E−13
5098

PH_hs_0026037
NUMB
numb homolog (Drosophila)
−2.20
1.463E−06
8650

PH_hs_0028884
ADORA2B
adenosine A2b receptor
−2.20
8.315E−08
136

PH_hs_0033588
RPSA|RPSAP58|R
ribosomal protein SA|ribosomal protein SA pseudogene 58|ribosomal protein SA pseudogene 9
−2.20
2.010E−03
3921|388524|65

PSAP9

3162

PH_hs_0046309
SPATA13
spermatogenesis associated 13
−2.20
1.390E−05
221178

PH_hs_0045586
SERPINB8
serpin peptidase inhibitor, clade B (ovalbumin), member 8
−2.20
6.632E−06
5271

PH_hs_0005026
CPOX
coproporphyrinogen oxidase
−2.19
3.861E−06
1371

PH_hs_0043149
RIN1
Ras and Rab interactor 1
−2.19
1.491E−05
9610

PH_hs_0010736
TMEM9
transmembrane protein 9
−2.19
5.519E−04
252839

PH_hs_0004852
FADD
Fas (TNFRSF6)-associated via death domain
−2.18
1.129E−10
8772

PH_hs_0000422
HPCAL1
hippocalcin-like 1
−2.17
1.475E−06
3241

PH_hs_0009969
PYCRL
pyrroline-5-carboxylate reductase-like
−2.17
6.696E−13
65263

PH_hs_0027745
BRMS1
breast cancer metastasis suppressor 1
−2.17
2.293E−07
25855

PH_hs_0043905
DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
−2.17
3.363E−09
1662

PH_hs_0022175
HEXB
hexosaminidase B (beta polypeptide)
−2.17
4.700E−11
3074

PH_hs_0027449
NDC80
NDC80 homolog, kinetochore complex component (S. cerevisiae)
−2.17
3.530E−05
10403

PH_hs_0048109
PRKCA
protein kinase C, alpha
−2.17
4.058E−04
5578

PH_hs_0018068
CDCA2
cell division cycle associated 2
−2.17
1.970E−13
157313

PH_hs_0003673
LAT2
linker for activation of T cells family, member 2
−2.17
1.108E−05
7462

PH_hs_0015815
PLEKHB2
pleckstrin homology domain containing, family B (evectins) member 2
−2.16
1.004E−09
55041

PH_hs_0022625
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
−2.16
2.090E−13
19

PH_hs_0014339
PSMC3IP
PSMC3 interacting protein
−2.16
4.121E−09
29893

PH_hs_0022058
RAB27B
RAB27B, member RAS oncogene family
−2.16
4.423E−03
5874

PH_hs_0025401
C16orf55
chromosome 16 open reading frame 55
−2.15
4.138E−10
124045

PH_hs_0013577
NSMCE4A
non-SMC element 4 homolog A (S. cerevisiae)
−2.15
2.095E−14
54780

PH_hs_0022541
EMG1
EMG1 nucleolar protein homolog (S. cerevisiae)
−2.15
6.127E−10
10436

PH_hs_0006106
RNF182
ring finger protein 182
−2.15
1.637E−05
221687

PH_hs_0009265
PHLDA2
pleckstrin homology-like domain, family A, member 2
−2.15
4.494E−15
7262

PH_hs_0023213
PCGF5
polycomb group ring finger 5
−2.15
5.154E−09
84333

PH_hs_0004905
ARHGAP22
Rho GTPase activating protein 22
−2.15
1.413E−14
58504

PH_hs_0025352
FANCG
Fanconi anemia, complementation group G
−2.15
1.996E−07
2189

PH_hs_0044342
BMPER
BMP binding endothelial regulator
−2.14
3.066E−06
168667

PH_hs_0000113
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
−2.14
5.009E−06
3113

PH_hs_0003763
CTNNAL1
catenin (cadherin-associated protein), alpha-like 1
−2.14
3.962E−06
8727

PH_hs_0005570
CKAP2L
cytoskeleton associated protein 2-like
−2.14
3.170E−10
150468

PH_hs_0035466
AKR1C3|AKR1C1
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)|aldo-keto reductase family 1,
−2.14
2.305E−07
8644|1645

member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

PH_hs_0004663
HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B
−2.13
2.522E−23
3182

PH_hs_0005188
TMEM14A
transmembrane protein 14A
−2.13
8.566E−03
28978

PH_hs_0002013
NCEH1
neutral cholesterol ester hydrolase 1
−2.13
2.530E−17
57552

PH_hs_0000702
MOXD1
monooxygenase, DBH-like 1
−2.13
1.089E−09
26002

PH_hs_0005006
PTPRG
protein tyrosine phosphatase, receptor type, G
−2.13
8.371E−04
5793

PH_hs_0017518
DTYMK
deoxythymidylate kinase (thymidylate kinase)
−2.12
1.088E−09
1841

PH_hs_0042247
TIPIN
TIMELESS interacting protein
−2.12
1.156E−06
54962

PH_hs_0022289
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
−2.11
9.926E−06
6574

PH_hs_0012791
HEY1
hairy/enhancer-of-split related with YRPW motif 1
−2.11
8.887E−12
23462

PH_hs_0028863
MLF1IP
MLF1 interacting protein
−2.11
1.191E−03
79682

PH_hs_0021993
FAHD2A|FAHD2B
fumarylacetoacetate hydrolase domain containing 2A|fumarylacetoacetate hydrolase domain containing 2B
−2.10
6.159E−07
51011|151313

PH_hs_0002385
RUSC2
RUN and SH3 domain containing 2
−2.10
6.746E−11
9853

PH_hs_0043353
KIAA1632
KIAA1632
−2.10
1.532E−07
57724

PH_hs_0024885
TMEM38B
transmembrane protein 38B
−2.09
7.526E−09
55151

PH_hs_0009375
LRRC23
leucine rich repeat containing 23
−2.09
1.860E−08
10233

PH_hs_0044235
DYRK3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
−2.08
2.299E−10
8444

PH_hs_0034798
LOC100508969
putative grifin-like
−2.08
9.554E−09
100508969

PH_hs_0043204
ODC1
ornithine decarboxylase 1
−2.08
5.220E−08
4953

PH_hs_0046065
ANKHD1
ankyrin repeat and KH domain containing 1
−2.08
3.873E−12
54882

PH_hs_0005412
C11orf70
chromosome 11 open reading frame 70
−2.08
3.906E−07
85016

PH_hs_0028482
NASP
nuclear autoantigenic sperm protein (histone-binding)
−2.07
4.280E−11
4678

PH_hs_0000915
DLC1
deleted in liver cancer 1
−2.07
2.059E−03
10395

PH_hs_0047678
C12orf32
chromosome 12 open reading frame 32
−2.07
4.459E−06
83695

PH_hs_0042321
OR1I1
olfactory receptor, family 1, subfamily I, member 1
−2.06
9.113E−11
126370

PH_hs_0048084
PTPRS
protein tyrosine phosphatase, receptor type, S
−2.06
5.021E−07
5802

PH_hs_0048842
ZNF175
zinc finger protein 175
−2.06
1.297E−10
7728

PH_hs_0048874
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
−2.05
5.595E−04
9429

PH_hs_0024590
C13orf27
chromosome 13 open reading frame 27
−2.05
8.181E−06
93081

PH_hs_0024747
LRP11
low density lipoprotein receptor-related protein 11
−2.05
1.488E−04
84918

PH_hs_0012692
E2F2
E2F transcription factor 2
−2.05
4.561E−05
1870

PH_hs_0020095
GINS2
GINS complex subunit 2 (Psf2 homolog)
−2.04
7.200E−11
51659

PH_hs_0025861
AURKB
aurora kinase B
−2.04
2.424E−11
9212

PH_hs_0019605
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
−2.04
4.429E−07
11020

PH_hs_0048618
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
−2.04
3.863E−03
9949

PH_hs_0048119
CD109
CD109 molecule
−2.04
6.177E−03
135228

PH_hs_0042874
CENPW
centromere protein W
−2.03
6.423E−14
387103

PH_hs_0024623
EZR
ezrin
−2.03
1.920E−11
7430

PH_hs_0043766
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
−2.03
6.098E−07
5570

PH_hs_0002625
C19orf60
chromosome 19 open reading frame 60
−2.03
2.310E−06
55049

PH_hs_0023361
KLHL5
kelch-like 5 (Drosophila)
−2.03
1.531E−08
51088

PH_hs_0031183
ZWINT
ZW10 interactor
−2.03
3.329E−17
11130

PH_hs_0026771
ASB1
ankyrin repeat and SOCS box-containing 1
−2.03
1.974E−03
51665

PH_hs_0028219
SEPT10
septin 10
−2.02
2.490E−13
151011

PH_hs_0024580
HIPK2
homeodomain interacting protein kinase 2
−2.02
1.851E−10
28996

PH_hs_0001552
USP31
ubiquitin specific peptidase 31
−2.02
1.077E−05
57478

PH_hs_0042401
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
−2.01
1.865E−12
611

PH_hs_0043636
TEAD4
TEA domain family member 4
−2.01
4.500E−08
7004

PH_hs_0045480
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
−2.01
9.149E−05
5721

PH_hs_0001205
LRRC49
leucine rich repeat containing 49
−2.01
1.154E−04
54839

PH_hs_0025052
E2F7
E2F transcription factor 7
−2.01
3.557E−03
144455

PH_hs_0000209
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
−2.01
1.640E−10
4734

PH_hs_0044438
GABPB1
GA binding protein transcription factor, beta subunit 1
−2.00
3.852E−03
2553

PH_hs_0003218
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
−2.00
5.416E−06
5966

PH_hs_0045994
MTCH1
mitochondrial carrier homolog 1 (C. elegans)
−2.00
5.971E−05
23787

PH_hs_0003990
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
−2.00
4.804E−04
5058

PH_hs_0002555
C5orf62
chromosome 5 open reading frame 62
−1.99
2.299E−11
85027

PH_hs_0005864
NPDC1
neural proliferation, differentiation and control, 1
−1.99
2.021E−09
56654

PH_hs_0023813
C13orf34
chromosome 13 open reading frame 34
−1.99
1.154E−10
79866

PH_hs_0002005
ARSJ
arylsulfatase family, member J
−1.98
1.017E−11
79642

PH_hs_0044571
CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
−1.98
3.026E−08
834

PH_hs_0045863
VEGFA
vascular endothelial growth factor A
−1.98
2.718E−06
7422

PH_hs_0048736
DUSP3
dual specificity phosphatase 3
−1.98
2.130E−04
1845

PH_hs_0006705
ASPM
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
−1.98
1.306E−12
259266

PH_hs_0046513
LILRB3
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
−1.98
1.265E−12
11025

PH_hs_0043795
TAGLN3
transgelin 3
−1.98
3.099E−02
29114

PH_hs_0049303
CCNA2
cyclin A2
−1.97
6.573E−04
890

PH_hs_0019549
GRB14
growth factor receptor-bound protein 14
−1.97
3.374E−04
2888

PH_hs_0015893
DDX39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
−1.97
4.474E−07
10212

PH_hs_0002060
KCTD4
potassium channel tetramerisation domain containing 4
−1.97
1.689E−03
386618

PH_hs_0048129
PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
−1.97
5.276E−16
5702

PH_hs_0016660
PRC1
protein regulator of cytokinesis 1
−1.97
1.588E−05
9055

PH_hs_0044572
TGM2
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
−1.97
1.335E−07
7052

PH_hs_0000579
NCAPD2
non-SMC condensin I complex, subunit D2
−1.96
5.770E−12
9918

PH_hs_0029923
DHX9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
−1.96
7.066E−05
1660

PH_hs_0005732
RAB3IP
RAB3A interacting protein (rabin3)
−1.96
2.555E−15
117177

PH_hs_0049709
MAP1LC3B2
microtubule-associated protein 1 light chain 3 beta 2
−1.96
7.038E−06
643246

PH_hs_0044611
GLRX2
glutaredoxin 2
−1.96
4.009E−17
51022

PH_hs_0015982
CCDC123
coiled-coil domain containing 123
−1.96
4.099E−05
84902

PH_hs_0004448
MCM5
minichromosome maintenance complex component 5
−1.96
1.824E−06
4174

PH_hs_0023978
CARHSP1
calcium regulated heat stable protein 1, 24 kDa
−1.96
1.397E−15
23589

PH_hs_0045723
FKBP1A
FK506 binding protein 1A, 12 kDa
−1.96
5.040E−06
2280

PH_hs_0003169
CLN6
ceroid-lipofuscinosis, neuronal 6, late infantile, variant
−1.95
7.612E−08
54982

PH_hs_0044805
TTC4|C1orf175-
tetratricopeptide repeat domain 4|C1orf175-TTC4 read-through transcript
−1.95
3.343E−07
7268|100527960

TTC4

PH_hs_0032582
C11orf24
chromosome 11 open reading frame 24
−1.95
4.562E−08
53838

PH_hs_0013285
AURKA
aurora kinase A
−1.95
1.390E−10
6790

PH_hs_0003188
CD164
CD164 molecule, sialomucin
−1.95
1.611E−05
8763

PH_hs_0006549
FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
−1.95
1.200E−04
2530

PH_hs_0002901
LIMK1
LIM domain kinase 1
−1.94
1.021E−09
3984

PH_hs_0031490
LOC728392
hypothetical protein LOC728392
−1.94
1.282E−04
728392

PH_hs_0047667
FOXL1
forkhead box L1
−1.94
3.480E−05
2300

PH_hs_0031360
SYPL1
synaptophysin-like 1
−1.94
8.342E−08
6856

PH_hs_0003454
ORC6
origin recognition complex, subunit 6
−1.94
6.145E−06
23594

PH_hs_0035763
CENPO
centromere protein O
−1.94
2.621E−09
79172

PH_hs_0008727
KIF13A
kinesin family member 13A
−1.94
3.486E−04
63971

PH_hs_0017351
C20orf71
chromosome 20 open reading frame 71
−1.94
5.213E−06
128861

PH_hs_0006918
SHCBP1
SHC SH2-domain binding protein 1
−1.94
6.876E−08
79801

PH_hs_0020941
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
−1.94
1.177E−04
54884

PH_hs_0024059
CCT7
chaperonin containing TCP1, subunit 7 (eta)
−1.94
7.956E−04
10574

PH_hs_0024259
MRPS27
mitochondrial ribosomal protein S27
−1.94
1.847E−03
23107

PH_hs_0049318
C10orf72
chromosome 10 open reading frame 72
−1.93
3.386E−08
196740

PH_hs_0047318
LIMCH1
LIM and calponin homology domains 1
−1.93
9.492E−08
22998

PH_hs_0048683
ALCAM
activated leukocyte cell adhesion molecule
−1.93
3.584E−06
214

PH_hs_0033361
ACOT7
acyl-CoA thioesterase 7
−1.92
9.630E−11
11332

PH_hs_0035398
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
−1.92
1.403E−07
116092

PH_hs_0047381
NCAM1
neural cell adhesion molecule 1
−1.92
1.741E−07
4684

PH_hs_0037695
GRAMD1C
GRAM domain containing 1C
−1.92
2.212E−04
54762

PH_hs_0005070
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
−1.92
1.093E−10
6505

PH_hs_0049714
FAM72B|LOC10050
family with sequence similarity 72, member B|hypothetical LOC100507552|family with sequence similarity 72, member
−1.92
6.626E−09
653820|1005075

7552|FAM72A|FAM
A|family with sequence similarity 72, member D

52|729533|7288

72D

33

PH_hs_0045672
ABL2
v-abl Abelson murine leukemia viral oncogene homolog 2
−1.92
2.253E−08
27

PH_hs_0004737
CETN2
centrin, EF-hand protein, 2
−1.92
5.190E−10
1069

PH_hs_0036109
DCTN3
dynactin 3 (p22)
−1.92
3.644E−08
11258

PH_hs_0033090
MGST1
microsomal glutathione S-transferase 1
−1.91
4.232E−10
4257

PH_hs_0047363
PLSCR1
phospholipid scramblase 1
−1.91
2.171E−06
5359

PH_hs_0013740
RGS17
regulator of G-protein signaling 17
−1.91
6.442E−05
26575

PH_hs_0043862
CYB5A
cytochrome b5 type A (microsomal)
−1.90
2.075E−04
1528

PH_hs_0026835
MPZL1
myelin protein zero-like 1
−1.90
4.916E−11
9019

PH_hs_0011511
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
−1.90
9.543E−14
9245

PH_hs_0048561
NIPAL3
NIPA-like domain containing 3
−1.90
1.433E−02
57185

PH_hs_0025231
ADAM23
ADAM metallopeptidase domain 23
−1.90
2.611E−04
8745

PH_hs_0043830
CDC25C
cell division cycle 25 homolog C (S. pombe)
−1.90
3.877E−09
995

PH_hs_0036785
MAP1S
microtubule-associated protein 1S
−1.90
1.501E−09
55201

PH_hs_0044920
UBD
ubiquitin D
−1.90
5.255E−04
10537

PH_hs_0030776
SAMD9
sterile alpha motif domain containing 9
−1.90
1.061E−05
54809

PH_hs_0045444
GLRX
glutaredoxin (thioltransferase)
−1.89
1.265E−05
2745

PH_hs_0023448
GSK3B
glycogen synthase kinase 3 beta
−1.89
2.146E−11
2932

PH_hs_0018571
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
−1.89
8.196E−10
5698

PH_hs_0004405
BLVRB
biliverdin reductase B (flavin reductase (NADPH))
−1.89
2.210E−13
645

PH_hs_0047836
DPF1
D4, zinc and double PHD fingers family 1
−1.89
1.901E−05
8193

PH_hs_0004430
FBXL7
F-box and leucine-rich repeat protein 7
−1.88
7.656E−06
23194

PH_hs_0035271
RNF181
ring finger protein 181
−1.88
4.517E−07
51255

PH_hs_0049491
RABL2B|RABL2A
RAB, member of RAS oncogene family-like 2B|RAB, member of RAS oncogene family-like 2A
−1.88
2.605E−02
11158|11159

PH_hs_0043330
IFI44
interferon-induced protein 44
−1.88
1.016E−03
10561

PH_hs_0045053
HPS1
Hermansky-Pudlak syndrome 1
−1.88
2.971E−13
3257

PH_hs_0047472
ECT2
epithelial cell transforming sequence 2 oncogene
−1.88
1.277E−05
1894

PH_hs_0032652
NPAS2
neuronal PAS domain protein 2
−1.87
1.303E−04
4862

PH_hs_0001423
PECI
peroxisomal D3,D2-enoyl-CoA isomerase
−1.87
3.689E−09
10455

PH_hs_0004651
MKI67
antigen identified by monoclonal antibody Ki-67
−1.87
7.102E−07
4288

PH_hs_0026788
FAM45A|FAM45B
family with sequence similarity 45, member A|family with sequence similarity 45, member A pseudogene
−1.87
3.004E−04
404636|55855

PH_hs_0010738
C15orf23
chromosome 15 open reading frame 23
−1.87
7.301E−10
90417

PH_hs_0001501
SPAG5
sperm associated antigen 5
−1.86
2.747E−10
10615

PH_hs_0026413
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
−1.86
6.848E−12
9955

PH_hs_0031096
C17orf76
chromosome 17 open reading frame 76
−1.86
1.145E−05
388341

PH_hs_0048770
FGF2
fibroblast growth factor 2 (basic)
−1.86
6.452E−04
2247

PH_hs_0022078
FLJ36031
hypothetical protein FLJ36031
−1.86
1.084E−09
168455

PH_hs_0031719
CCL26
chemokine (C-C motif) ligand 26
−1.86
5.373E−08
10344

PH_hs_0026360
UCK2
uridine-cytidine kinase 2
−1.85
2.753E−05
7371

PH_hs_0044943
CDC20
cell division cycle 20 homolog (S. cerevisiae)
−1.85
7.409E−10
991

PH_hs_0010421
CSF1
colony stimulating factor 1 (macrophage)
−1.85
3.797E−06
1435

PH_hs_0025732
RCN3
reticulocalbin 3, EF-hand calcium binding domain
−1.85
2.576E−04
57333

PH_hs_0022666
LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
−1.85
9.879E−06
11157

PH_hs_0007965
C1orf97
chromosome 1 open reading frame 97
−1.85
9.451E−06
84791

PH_hs_0023973
ADK
adenosine kinase
−1.85
1.721E−08
132

PH_hs_0046086
TMEM48
transmembrane protein 48
−1.85
1.162E−02
55706

PH_hs_0049587
CTAG2|CTAG1B|C
cancer/testis antigen 2|cancer/testis antigen 1 B|cancer/testis antigen 1A
−1.85
1.189E−09
30848|1485|246

TAG1A

100

PH_hs_0030319
RPL14
ribosomal protein L14
−1.85
2.669E−03
9045

PH_hs_0035526
C6orf48
chromosome 6 open reading frame 48
−1.85
9.450E−07
50854

PH_hs_0026290
PPIL5
peptidylprolyl isomerase (cyclophilin)-like 5
−1.84
2.236E−07
122769

PH_hs_0029180
RPL39L
ribosomal protein L39-like
−1.84
3.416E−06
116832

PH_hs_0027863
LRRC45
leucine rich repeat containing 45
−1.84
5.992E−05
201255

PH_hs_0026085
SOAT1
sterol O-acyltransferase 1
−1.84
1.289E−05
6646

PH_hs_0015035
BIRC2
baculoviral IAP repeat-containing 2
−1.84
4.236E−09
329

PH_hs_0001378
CEP55
centrosomal protein 55 kDa
−1.84
9.382E−09
55165

PH_hs_0010763
SQSTM1
sequestosome 1
−1.84
1.187E−04
8878

PH_hs_0020300
VCAN
versican
−1.84
6.305E−07
1462

PH_hs_0022918
GOPC
golgi-associated PDZ and coiled-coil motif containing
−1.84
2.346E−03
57120

PH_hs_0031530
MRPS11
mitochondrial ribosomal protein S11
−1.84
8.221E−07
64963

PH_hs_0042325
HSCB
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
−1.84
9.898E−05
150274

PH_hs_0000567
EVI2B
ecotropic viral integration site 2B
−1.84
1.489E−06
2124

PH_hs_0002383
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
−1.84
2.824E−08
11186

PH_hs_0048795
HAUS2
HAUS augmin-like complex, subunit 2
−1.84
2.310E−07
55142

PH_hs_0028864
GREM1
gremlin 1
−1.84
4.913E−06
26585

PH_hs_0009344
EHD1
EH-domain containing 1
−1.84
1.397E−09
10938

PH_hs_0037874
C16orf46
chromosome 16 open reading frame 46
−1.84
4.630E−04
123775

PH_hs_0020115
SNHG1
small nucleolar RNA host gene 1 (non-protein coding)
−1.84
8.180E−05
23642

PH_hs_0019671
MRPL11
mitochondrial ribosomal protein L11
−1.83
8.255E−09
65003

PH_hs_0009243
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105 kDa
−1.83
3.265E−08
8821

PH_hs_0045821
ABCD3
ATP-binding cassette, sub-family D (ALD), member 3
−1.83
2.197E−03
5825

PH_hs_0044849
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
−1.83
1.283E−03
54927

PH_hs_0008982
NEURL3
neuralized homolog 3 (Drosophila) pseudogene
−1.83
1.881E−06
93082

PH_hs_0035355
HAT1
histone acetyltransferase 1
−1.83
3.987E−03
8520

PH_hs_0007225
DTL
denticleless homolog (Drosophila)
−1.83
1.196E−04
51514

PH_hs_0002142
DERA
deoxyribose-phosphate aldolase (putative)
−1.83
4.940E−07
51071

PH_hs_0019274
ORAOV1
oral cancer overexpressed 1
−1.83
8.843E−08
220064

PH_hs_0004122
FAM83D
family with sequence similarity 83, member D
−1.83
3.065E−05
81610

PH_hs_0000218
DPYD
dihydropyrimidine dehydrogenase
−1.82
2.018E−06
1806

PH_hs_0025971
PHB2
prohibitin 2
−1.82
8.339E−04
11331

PH_hs_0028689
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
−1.82
2.606E−05
2919

PH_hs_0045959
TRIOBP
TRIO and F-actin binding protein
−1.82
1.330E−04
11078

PH_hs_0001028
SEC61G
Sec61 gamma subunit
−1.82
4.824E−03
23480

PH_hs_0043402
AEN
apoptosis enhancing nuclease
−1.82
5.822E−06
64782

PH_hs_0047904
TGFBR2
transforming growth factor, beta receptor II (70/80 kDa)
−1.82
7.668E−05
7048

PH_hs_0047735
GPR115
G protein-coupled receptor 115
−1.82
2.161E−02
221393

PH_hs_0004541
THOP1
thimet oligopeptidase 1
−1.82
1.936E−10
7064

PH_hs_0014145
TP53TG1
TP53 target 1 (non-protein coding)
−1.82
1.314E−02
11257

PH_hs_0048262
TBC1D2
TBC1 domain family, member 2
−1.81
9.123E−10
55357

PH_hs_0031937
C9orf30
chromosome 9 open reading frame 30
−1.81
1.613E−06
91283

PH_hs_0019643
POP7
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
−1.81
1.387E−05
10248

PH_hs_0005815
PBK
PDZ binding kinase
−1.81
1.191E−09
55872

PH_hs_0011459
BRCA1
breast cancer 1, early onset
−1.81
1.268E−09
672

PH_hs_0035485
NDUFS8
NADH dehydrogenase (ubiquinone) Fe—S protein 8, 23 kDa (NADH-coenzyme Q reductase)
−1.81
5.947E−07
4728

PH_hs_0000213
BIRC5
baculoviral IAP repeat-containing 5
−1.81
1.085E−06
332

PH_hs_0029069
TMEM106C
transmembrane protein 106C
−1.81
2.577E−04
79022

PH_hs_0046226
TMEM44
transmembrane protein 44
−1.81
1.339E−04
93109

PH_hs_0040139
HSPA8
heat shock 70 kDa protein 8
−1.81
5.682E−05
3312

PH_hs_0044244
NPHP1
nephronophthisis 1 (juvenile)
−1.81
3.673E−05
4867

PH_hs_0043288
RHEB
Ras homolog enriched in brain
−1.80
6.510E−06
6009

PH_hs_0023555
MCFD2
multiple coagulation factor deficiency 2
−1.80
1.300E−11
90411

PH_hs_0002916
ATF1
activating transcription factor 1
−1.80
3.830E−03
466

PH_hs_0044140
C1orf91
chromosome 1 open reading frame 91
−1.80
1.686E−02
56063

PH_hs_0024428
CD9
CD9 molecule
−1.80
1.100E−08
928

PH_hs_0025533
VBP1
von Hippel-Lindau binding protein 1
−1.80
2.488E−04
7411

PH_hs_0043687
CENPM
centromere protein M
−1.80
7.674E−06
79019

PH_hs_0003656
NKX3-1
NK3 homeobox 1
−1.80
7.447E−06
4824

PH_hs_0040733
HSP90AA1
heat shock protein 90 kDa alpha (cytosolic), class A member 1
−1.80
6.393E−08
3320

PH_hs_0044161
LACTB
lactamase, beta
−1.80
2.174E−04
114294

PH_hs_0001230
AGTRAP
angiotensin II receptor-associated protein
−1.80
5.200E−11
57085

PH_hs_0018569
PPIF
peptidylprolyl isomerase F
−1.79
4.753E−09
10105

PH_hs_0004341
CENPE
centromere protein E, 312 kDa
−1.79
9.609E−10
1062

PH_hs_0025444
VIM
vimentin
−1.79
9.111E−08
7431

PH_hs_0049740
SMPD4|LOC150776
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)|sphingomyelin phosphodiesterase 4,
−1.79
1.051E−05
55627|150776

neutral membrane pseudogene

PH_hs_0028715
LDHA
lactate dehydrogenase A
−1.79
6.701E−08
3939

PH_hs_0000768
EPN2
epsin 2
−1.79
4.737E−04
22905

PH_hs_0005724
LHX6
LIM homeobox 6
−1.79
1.203E−07
26468

PH_hs_0025379
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
−1.79
8.228E−06
1032

PH_hs_0033319
NPC2
Niemann-Pick disease, type C2
−1.78
4.591E−06
10577

PH_hs_0029964
MYADM
myeloid-associated differentiation marker
−1.78
3.356E−03
91663

PH_hs_0037156
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
−1.78
4.154E−06
2820

PH_hs_0039916
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
−1.78
4.429E−04
1936

PH_hs_0010658
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
−1.78
4.481E−04
5696

PH_hs_0004776
CKS2
CDC28 protein kinase regulatory subunit 2
−1.77
1.551E−10
1164

PH_hs_0004583
LHFPL2
lipoma HMGIC fusion partner-like 2
−1.77
1.061E−07
10184

PH_hs_0000326
SOD3
superoxide dismutase 3, extracellular
−1.77
1.803E−06
6649

PH_hs_0022094
SAE1
SUMO1 activating enzyme subunit 1
−1.77
5.938E−05
10055

PH_hs_0004711
RGS3
regulator of G-protein signaling 3
−1.77
1.651E−05
5998

PH_hs_0025677
PRNP
prion protein
−1.77
5.259E−07
5621

PH_hs_0000080
CSTB
cystatin B (stefin B)
−1.77
2.512E−09
1476

PH_hs_0045464
NOP56
NOP56 ribonucleoprotein homolog (yeast)
−1.76
1.089E−05
10528

PH_hs_0047402
RP2
retinitis pigmentosa 2 (X-linked recessive)
−1.76
1.033E−04
6102

PH_hs_0042943
TCTEX1D2
Tctex1 domain containing 2
−1.76
4.658E−05
255758

PH_hs_0024334
CSF3R
colony stimulating factor 3 receptor (granulocyte)
−1.76
3.205E−02
1441

PH_hs_0010296
TROAP
trophinin associated protein (tastin)
−1.76
1.262E−10
10024

PH_hs_0016806
CECR4
cat eye syndrome chromosome region, candidate 4 (non-protein coding)
−1.76
1.425E−03
100130717

PH_hs_0005831
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
−1.75
6.045E−07
8507

PH_hs_0022064
PITRM1
pitrilysin metallopeptidase 1
−1.75
5.754E−08
10531

PH_hs_0032378
TRNAU1AP
tRNA selenocysteine 1 associated protein 1
−1.75
1.843E−03
54952

PH_hs_0045445
HLA-F
major histocompatibility complex, class I, F
−1.75
8.434E−04
3134

PH_hs_0032575
CCR1
chemokine (C-C motif) receptor 1
−1.75
1.064E−05
1230

PH_hs_0028584
LIMS3|LOC1002886
LIM and senescent cell antigen-like domains 3|LIM and senescent cell antigen-like-containing domain protein 3-like
−1.75
4.363E−04
96626|10028869

95

5

PH_hs_0047045
PRR9
proline rich 9
−1.75
1.345E−03
574414

PH_hs_0048792
ETV1
ets variant 1
−1.75
1.341E−02
2115

PH_hs_0015013
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
−1.75
4.647E−04
80218

PH_hs_0049044
SOCS3
suppressor of cytokine signaling 3
−1.75
1.625E−09
9021

PH_hs_0029118
OASL
2′-5′-oligoadenylate synthetase-like
−1.75
7.921E−04
8638

PH_hs_0043563
LYAR
Ly1 antibody reactive homolog (mouse)
−1.74
6.522E−04
55646

PH_hs_0031222
CDCA8
cell division cycle associated 8
−1.74
8.079E−04
55143

PH_hs_0005155
PITPNM1
phosphatidylinositol transfer protein, membrane-associated 1
−1.74
1.573E−04
9600

PH_hs_0031307
HSP90AB1|HSP90
heat shock protein 90 kDa alpha (cytosolic), class B member 1|heat shock protein 90 kDa alpha (cytosolic), class B member
−1.74
3.888E−13
3326|3327|3916

AB3P|HSP90AB2P
3 (pseudogene)|heat shock protein 90 kDa alpha (cytosolic), class B member 2 (pseudogene)

34

PH_hs_0019919
PXMP2
peroxisomal membrane protein 2, 22 kDa
−1.74
1.454E−03
5827

PH_hs_0012993
KATNAL1
katanin p60 subunit A-like 1
−1.74
1.110E−03
84056

PH_hs_0031317
TUBA4A
tubulin, alpha 4a
−1.74
9.686E−06
7277

PH_hs_0004487
AP3M2
adaptor-related protein complex 3, mu 2 subunit
−1.74
2.334E−05
10947

PH_hs_0047687
SMC5
structural maintenance of chromosomes 5
−1.74
4.946E−03
23137

PH_hs_0048496
AKAP12
A kinase (PRKA) anchor protein 12
−1.74
1.603E−04
9590

PH_hs_0037808
USP18
ubiquitin specific peptidase 18
−1.74
6.540E−05
11274

PH_hs_0001880
TUBG1
tubulin, gamma 1
−1.73
3.335E−04
7283

PH_hs_0030008
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
−1.73
2.207E−08
5708

PH_hs_0001260
SH2B3
SH2B adaptor protein 3
−1.73
1.612E−09
10019

PH_hs_0049148
OSMR
oncostatin M receptor
−1.73
5.617E−05
9180

PH_hs_0048215
HABP4
hyaluronan binding protein 4
−1.73
7.845E−05
22927

PH_hs_0005068
DOHH
deoxyhypusine hydroxylase/monooxygenase
−1.73
2.286E−08
83475

PH_hs_0004488
PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
−1.73
6.837E−07
9088

PH_hs_0025165
COX7A2L
cytochrome c oxidase subunit VIIa polypeptide 2 like
−1.73
4.384E−03
9167

PH_hs_0019824
EIF1AD
eukaryotic translation initiation factor 1A domain containing
−1.73
7.705E−04
84285

PH_hs_0002211
NET1
neuroepithelial cell transforming 1
−1.73
1.880E−03
10276

PH_hs_0024093
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
−1.73
7.944E−04
1783

PH_hs_0048670
CPEB1
cytoplasmic polyadenylation element binding protein 1
−1.72
5.658E−09
64506

PH_hs_0008058
C1QL1
complement component 1, q subcomponent-like 1
−1.72
2.978E−04
10882

PH_hs_0009984
C11orf82
chromosome 11 open reading frame 82
−1.72
6.784E−04
220042

PH_hs_0003062
MRPL22
mitochondrial ribosomal protein L22
−1.72
1.695E−09
29093

PH_hs_0010617
PSMD14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
−1.72
1.516E−04
10213

PH_hs_0000227
GFPT1
glutamine- fructose-6-phosphate transaminase 1
−1.72
1.886E−06
2673

PH_hs_0004454
BTG3
BTG family, member 3
−1.72
5.605E−12
10950

PH_hs_0003616
MRPS28
mitochondrial ribosomal protein S28
−1.72
4.247E−03
28957

PH_hs_0024325
SNX25
sorting nexin 25
−1.72
1.708E−02
83891

PH_hs_0030964
S100A16
S100 calcium binding protein A16
−1.72
1.813E−06
140576

PH_hs_0048970
SFMBT1
Scm-like with four mbt domains 1
−1.72
1.226E−03
51460

PH_hs_0004701
KLF10
Kruppel-like factor 10
−1.71
1.449E−05
7071

PH_hs_0035153
APOBEC3A|LAIR1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A|leukocyte-associated immunoglobulin-like receptor 1
−1.71
6.693E−06
200315|3903

PH_hs_0006320
SRSF3
serine/arginine-rich splicing factor 3
−1.71
3.541E−03
6428

PH_hs_0018698
RRM1
ribonucleotide reductase M1
−1.71
2.107E−09
6240

PH_hs_0005575
FBL
fibrillarin
−1.71
4.280E−07
2091

PH_hs_0004726
POLD3
polymerase (DNA-directed), delta 3, accessory subunit
−1.71
5.972E−05
10714

PH_hs_0002377
CECR5
cat eye syndrome chromosome region, candidate 5
−1.71
2.839E−03
27440

PH_hs_0004290
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 kDa
−1.71
5.775E−09
4704

PH_hs_0000569
ATP2A3
ATPase, Ca++ transporting, ubiquitous
−1.71
1.598E−06
489

PH_hs_0002795
MCTP2
multiple C2 domains, transmembrane 2
−1.71
1.949E−06
55784

PH_hs_0022309
VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
−1.71
1.132E−04
9559

PH_hs_0045852
TPM3
tropomyosin 3
−1.70
2.380E−05
7170

PH_hs_0014235
CCDC107
coiled-coil domain containing 107
−1.70
1.839E−10
203260

PH_hs_0048967
RAPH1
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
−1.70
1.103E−07
65059

PH_hs_0047307
KIAA1524
KIAA1524
−1.70
7.213E−08
57650

PH_hs_0037802
GPC6
glypican 6
−1.70
4.865E−05
10082

PH_hs_0044814
KIF4A
kinesin family member 4A
−1.70
5.116E−07
24137

PH_hs_0047818
MAP4
microtubule-associated protein 4
−1.70
3.260E−04
4134

PH_hs_0029774
ELL
elongation factor RNA polymerase II
−1.69
5.895E−09
8178

PH_hs_0026668
ENO2
enolase 2 (gamma, neuronal)
−1.69
1.119E−04
2026

PH_hs_0000408
TBC1D13
TBC1 domain family, member 13
−1.69
1.019E−06
54662

PH_hs_0042797
OR6N2
olfactory receptor, family 6, subfamily N, member 2
−1.69
3.217E−04
81442

PH_hs_0022981
PAPOLA
poly(A) polymerase alpha
−1.69
2.295E−05
10914

PH_hs_0042225
DUSP5
dual specificity phosphatase 5
−1.69
6.939E−05
1847

PH_hs_0044747
KPNA6
karyopherin alpha 6 (importin alpha 7)
−1.69
4.891E−04
23633

PH_hs_0025873
CEP152
centrosomal protein 152 kDa
−1.69
2.041E−03
22995

PH_hs_0016481
FANCI
Fanconi anemia, complementation group I
−1.69
7.607E−06
55215

PH_hs_0012268
MICB
MHC class I polypeptide-related sequence B
−1.69
9.435E−05
4277

PH_hs_0024760
DPY19L1
dpy-19-like 1 (C. elegans)
−1.69
2.089E−04
23333

PH_hs_0025234
OXR1
oxidation resistance 1
−1.69
7.896E−05
55074

PH_hs_0014119
BRF2
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
−1.69
2.754E−03
55290

PH_hs_0049053
ADAM9
ADAM metallopeptidase domain 9
−1.69
1.435E−03
8754

PH_hs_0044243
RRP1
ribosomal RNA processing 1 homolog (S. cerevisiae)
−1.69
3.245E−03
8568

PH_hs_0011720
TMEM97
transmembrane protein 97
−1.69
2.101E−06
27346

PH_hs_0023589
ACOT9
acyl-CoA thioesterase 9
−1.68
4.467E−08
23597

PH_hs_0043078
PPPDE1
PPPDE peptidase domain containing 1
−1.68
4.404E−04
51029

PH_hs_0006882
CDT1
chromatin licensing and DNA replication factor 1
−1.68
1.422E−06
81620

PH_hs_0000282
EPS8
epidermal growth factor receptor pathway substrate 8
−1.68
7.106E−06
2059

PH_hs_0024883
PPP6R1
protein phosphatase 6, regulatory subunit 1
−1.68
1.260E−02
22870

PH_hs_0033354
PIN1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
−1.68
1.860E−08
5300

PH_hs_0027206
UHRF1
ubiquitin-like with PHD and ring finger domains 1
−1.68
2.378E−03
29128

PH_hs_0000937
KIF11
kinesin family member 11
−1.68
3.453E−05
3832

PH_hs_0010330
ARHGAP11A
Rho GTPase activating protein 11A
−1.68
8.275E−04
9824

PH_hs_0027568
FARSB
phenylalanyl-tRNA synthetase, beta subunit
−1.68
5.779E−06
10056

PH_hs_0047336
BMPR1B
bone morphogenetic protein receptor, type IB
−1.68
1.566E−05
658

PH_hs_0007062
SCAF4
SR-related CTD-associated factor 4
−1.67
7.028E−05
57466

PH_hs_0007254
PHLDB3
pleckstrin homology-like domain, family B, member 3
−1.67
8.289E−03
653583

PH_hs_0033183
CHAF1A
chromatin assembly factor 1, subunit A (p150)
−1.67
9.186E−10
10036

PH_hs_0044932
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)
−1.67
5.315E−05
4085

PH_hs_0047787
ARRDC4
arrestin domain containing 4
−1.67
2.673E−05
91947

PH_hs_0008721
CPNE7
copine VII
−1.67
7.112E−12
27132

PH_hs_0008113
SKA1
spindle and kinetochore associated complex subunit 1
−1.67
9.034E−09
220134

PH_hs_0044580
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
−1.66
1.644E−10
972

PH_hs_0047141
BNIP3
BCL2/adenovirus E1B 19 kDa interacting protein 3
−1.66
4.822E−05
664

PH_hs_0001261
UVRAG
UV radiation resistance associated gene
−1.66
2.121E−05
7405

PH_hs_0002556
ETNK1
ethanolamine kinase 1
−1.66
3.075E−03
55500

PH_hs_0024492
RABL5
RAB, member RAS oncogene family-like 5
−1.66
8.791E−04
64792

PH_hs_0035332
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29 kDa)
−1.66
1.201E−03
5050

PH_hs_0031400
FMR1
fragile X mental retardation 1
−1.66
7.029E−05
2332

PH_hs_0003608
ZCCHC17
zinc finger, CCHC domain containing 17
−1.66
1.069E−04
51538

PH_hs_0004961
CENPQ
centromere protein Q
−1.66
3.290E−03
55166

PH_hs_0022104
DPP7
dipeptidyl-peptidase 7
−1.66
1.011E−03
29952

PH_hs_0023179
FOXP1
forkhead box P1
−1.66
1.860E−06
27086

PH_hs_0005753
RIPK2
receptor-interacting serine-threonine kinase 2
−1.66
3.304E−07
8767

PH_hs_0034855
SLC18A3
solute carrier family 18 (vesicular acetylcholine), member 3
−1.66
3.964E−02
6572

PH_hs_0027806
METRN
meteorin, glial cell differentiation regulator
−1.66
6.883E−04
79006

PH_hs_0004239
CASP4
caspase 4, apoptosis-related cysteine peptidase
−1.65
5.104E−03
837

PH_hs_0004095
HAUS8
HAUS augmin-like complex, subunit 8
−1.65
1.813E−02
93323

PH_hs_0035325
EIF6
eukaryotic translation initiation factor 6
−1.65
6.351E−05
3692

PH_hs_0049245
SMC3
structural maintenance of chromosomes 3
−1.65
1.596E−03
9126

PH_hs_0047576
GXYLT1
glucoside xylosyltransferase 1
−1.65
1.824E−04
283464

PH_hs_0035543
H2AFZ
H2A histone family, member Z
−1.65
2.566E−05
3015

PH_hs_0002639
TMEM51
transmembrane protein 51
−1.65
3.158E−03
55092

PH_hs_0023607
CTTN
cortactin
−1.65
7.125E−08
2017

PH_hs_0043741
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
−1.65
3.436E−04
9521

PH_hs_0010392
DPYSL2
dihydropyrimidinase-like 2
−1.65
6.601E−04
1808

PH_hs_0044640
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18 kDa
−1.65
4.779E−03
6884

PH_hs_0000792
DYNC1H1
dynein, cytoplasmic 1, heavy chain 1
−1.65
2.037E−10
1778

PH_hs_0048854
UTP15
UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
−1.65
2.575E−05
84135

PH_hs_0012697
WBP2
WW domain binding protein 2
−1.65
1.728E−03
23558

PH_hs_0048257
IRAK2
interleukin-1 receptor-associated kinase 2
−1.65
4.036E−09
3656

PH_hs_0029627
FAM195B
family with sequence similarity 195, member B
−1.65
5.379E−06
348262

PH_hs_0044919
GLRX3
glutaredoxin 3
−1.65
7.437E−04
10539

PH_hs_0035080
LOC100508928
hypothetical protein LOC100508928
−1.64
2.930E−02
100508928

PH_hs_0048932
PCNX
pecanex homolog (Drosophila)
−1.64
2.578E−04
22990

PH_hs_0045569
NME1
non-metastatic cells 1, protein (NM23A) expressed in
−1.64
5.426E−03
4830

PH_hs_0044216
PPPDE2
PPPDE peptidase domain containing 2
−1.64
2.451E−05
27351

PH_hs_0004174
HMMR
hyaluronan-mediated motility receptor (RHAMM)
−1.64
4.985E−03
3161

PH_hs_0004526
PSMD8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
−1.64
1.259E−05
5714

PH_hs_0021964
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (1 blood group)
−1.64
5.447E−06
2651

PH_hs_0024529
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
−1.64
3.357E−03
64332

PH_hs_0047732
PRDM8
PR domain containing 8
−1.64
3.460E−03
56978

PH_hs_0033509
RPL36AL|RPL36A
ribosomal protein L36a-like|ribosomal protein L36a
−1.64
8.830E−04
6166|6173

PH_hs_0011496
PEA15
phosphoprotein enriched in astrocytes 15
−1.64
1.557E−02
8682

PH_hs_0006140
SIVA1
SIVA1, apoptosis-inducing factor
−1.64
1.912E−08
10572

PH_hs_0034155
LRRC8E
leucine rich repeat containing 8 family, member E
−1.64
6.525E−10
80131

PH_hs_0005514
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
−1.64
9.099E−07
84803

PH_hs_0022980
STMN4
stathmin-like 4
−1.64
3.410E−03
81551

PH_hs_0027288
DDA1
DET1 and DDB1 associated 1
−1.64
2.791E−05
79016

PH_hs_0025525
CLU
clusterin
−1.64
5.676E−05
1191

PH_hs_0049199
DDX6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
−1.64
4.826E−08
1656

PH_hs_0046136
ALS2
amyotrophic lateral sclerosis 2 (juvenile)
−1.64
4.555E−06
57679

PH_hs_0025324
TXNRD1
thioredoxin reductase 1
−1.64
6.177E−05
7296

PH_hs_0032742
MRPL14
mitochondrial ribosomal protein L14
−1.64
1.879E−05
64928

PH_hs_0044203
C20orf24|TGIF2-
chromosome 20 open reading frame 24|TGIF2-C20orf24 read-through transcript
−1.64
5.281E−03
55969|10052794

C20ORF24

3

PH_hs_0044654
LMNA
lamin A/C
−1.63
1.321E−04
4000

PH_hs_0023583
ATAD2
ATPase family, AAA domain containing 2
−1.63
1.061E−02
29028

PH_hs_0043661
DEPDC1
DEP domain containing 1
−1.63
1.637E−03
55635

PH_hs_0042194
EXOSC8
exosome component 8
−1.63
3.802E−04
11340

PH_hs_0046189
LAS1L
LAS1-like (S. cerevisiae)
−1.63
1.049E−04
81887

PH_hs_0044204
C3orf75
chromosome 3 open reading frame 75
−1.63
2.969E−02
54859

PH_hs_0043707
MEST
mesoderm specific transcript homolog (mouse)
−1.63
3.780E−04
4232

PH_hs_0047544
C1R
complement component 1, r subcomponent
−1.62
1.530E−04
715

PH_hs_0012041
SMAGP
small cell adhesion glycoprotein
−1.62
1.812E−05
57228

PH_hs_0009437
TOP2A
topoisomerase (DNA) II alpha 170 kDa
−1.62
4.278E−08
7153

PH_hs_0007455
PHTF2
putative homeodomain transcription factor 2
−1.62
8.711E−03
57157

PH_hs_0049025
TGFBR1
transforming growth factor, beta receptor 1
−1.62
9.826E−03
7046

PH_hs_0048444
VAV2
vav 2 guanine nucleotide exchange factor
−1.62
3.484E−04
7410

PH_hs_0042046
STS
steroid sulfatase (microsomal), isozyme S
−1.62
5.977E−04
412

PH_hs_0004789
PITX1
paired-like homeodomain 1
−1.62
1.482E−02
5307

PH_hs_0015031
REEP4
receptor accessory protein 4
−1.62
5.035E−10
80346

PH_hs_0003757
FLNC
filamin C, gamma
−1.62
2.953E−05
2318

PH_hs_0017279
RPL28
ribosomal protein L28
−1.62
1.187E−05
6158

PH_hs_0042165
CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2
−1.62
8.088E−09
94032

PH_hs_0023492
ANXA1
annexin A1
−1.62
2.539E−10
301

PH_hs_0027828
C11orf17
chromosome 11 open reading frame 17
−1.62
6.499E−05
56672

PH_hs_0047497
CEP120
centrosomal protein 120 kDa
−1.62
5.099E−07
153241

PH_hs_0016835
RALGAPB
Ral GTPase activating protein, beta subunit (non-catalytic)
−1.62
2.171E−06
57148

PH_hs_0005632
COL12A1
collagen, type XII, alpha 1
−1.61
3.006E−03
1303

PH_hs_0048738
CCDC88A
coiled-coil domain containing 88A
−1.61
1.003E−05
55704

PH_hs_0002640
EFNB2
ephrin-B2
−1.61
1.286E−04
1948

PH_hs_0028809
ATAD3A|ATAD3B|L
ATPase family, AAA domain containing 3A|ATPase family, AAA domain containing 3B|ATPase family AAA domain-
−1.61
9.305E−06
55210|83858|73

OC732419
containing protein 3B-like

2419

PH_hs_0030980
C22orf13
chromosome 22 open reading frame 13
−1.61
1.915E−02
83606

PH_hs_0005089
IMP4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
−1.61
8.466E−03
92856

PH_hs_0027124
LPXN
leupaxin
−1.61
8.650E−05
9404

PH_hs_0027049
STRAP
serine/threonine kinase receptor associated protein
−1.61
9.166E−06
11171

PH_hs_0025102
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
−1.61
5.584E−07
1174

PH_hs_0027140
RAD54L
RAD54-like (S. cerevisiae)
−1.61
1.114E−03
8438

PH_hs_0016469
ANKRD13B
ankyrin repeat domain 13B
−1.61
1.169E−04
124930

PH_hs_0020362
CDCA5
cell division cycle associated 5
−1.61
1.999E−09
113130

PH_hs_0024860
LCMT1
leucine carboxyl methyltransferase 1
−1.61
1.182E−04
51451

PH_hs_0012886
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
−1.60
1.837E−05
1027

PH_hs_0004483
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
−1.60
1.153E−07
9787

PH_hs_0048190
YOD1
YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)
−1.60
9.987E−04
55432

PH_hs_0005179
BLOC1S1-
BLOC1S1-RDH5 read-through transcript|biogenesis of lysosomal organelles complex-1, subunit 1
−1.60
1.485E−07
100528022|2647

RDH5|BLOC1S1

PH_hs_0048562
EXOSC2
exosome component 2
−1.60
1.177E−02
23404

PH_hs_0010222
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
−1.60
4.901E−04
8482

PH_hs_0035730
EFCAB7
EF-hand calcium binding domain 7
−1.60
3.417E−03
84455

PH_hs_0022760
C9orf30|C9orf30-
chromosome 9 open reading frame 30|C9orf30-TMEFF1 read-through transcript
−1.60
4.727E−03
91283|10052669

TMEFF1

4

PH_hs_0043696
SALL1
sal-like 1 (Drosophila)
−1.60
8.071E−05
6299

PH_hs_0031970
TTLL4
tubulin tyrosine ligase-like family, member 4
−1.60
2.928E−03
9654

PH_hs_0009664
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
−1.60
4.801E−06
396

PH_hs_0047984
VPS26B
vacuolar protein sorting 26 homolog B (S. pombe)
−1.60
3.761E−02
112936

PH_hs_0009153
MAP3K5
mitogen-activated protein kinase kinase kinase 5
−1.60
3.131E−05
4217

PH_hs_0048564
PDE4DIP
phosphodiesterase 4D interacting protein
−1.60
2.976E−02
9659

PH_hs_0008761
PTGES
prostaglandin E synthase
−1.60
9.335E−06
9536

PH_hs_0044962
LOC100190939
hypothetical LOC100190939
−1.60
1.105E−07
100190939

PH_hs_0023587
PRPF40A
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
−1.60
3.951E−05
55660

PH_hs_0000565
TMEM164
transmembrane protein 164
−1.59
4.785E−05
84187

PH_hs_0022049
CHEK1
CHK1 checkpoint homolog (S. pombe)
−1.59
1.230E−02
1111

PH_hs_0044127
RPL7L1
ribosomal protein L7-like 1
−1.59
3.760E−06
285855

PH_hs_0030773
FIGNL1
fidgetin-like 1
−1.59
3.941E−07
63979

PH_hs_0025217
MPRIP
myosin phosphatase Rho interacting protein
−1.59
2.391E−03
23164

PH_hs_0029324
TCEB2
transcription elongation factor B (SIII), polypeptide 2 (18 kDa, elongin B)
−1.59
6.908E−04
6923

PH_hs_0048518
ZFP36L2
zinc finger protein 36, C3H type-like 2
−1.59
1.059E−02
678

PH_hs_0045853
TTK
TTK protein kinase
−1.59
8.529E−06
7272

PH_hs_0009005
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
−1.59
2.606E−04
3678

PH_hs_0001187
GNPAT
glyceronephosphate O-acyltransferase
−1.59
4.097E−06
8443

PH_hs_0031229
LOC399959
hypothetical LOC399959
−1.59
7.124E−03
399959

PH_hs_0025859
MRPL38
mitochondrial ribosomal protein L38
−1.59
3.931E−02
64978

PH_hs_0004760
LOXL2
lysyl oxidase-like 2
−1.59
1.995E−10
4017

PH_hs_0005216
LLGL1
lethal giant larvae homolog 1 (Drosophila)
−1.59
9.464E−03
3996

PH_hs_0002641
PMVK
phosphomevalonate kinase
−1.59
1.455E−06
10654

PH_hs_0002255
ELOVL1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
−1.59
6.869E−07
64834

PH_hs_0004585
EIF4E
eukaryotic translation initiation factor 4E
−1.58
3.365E−07
1977

PH_hs_0030583
TAF1A
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48 kDa
−1.58
1.399E−02
9015

PH_hs_0026629
CLK3
CDC-like kinase 3
−1.58
7.459E−03
1198

PH_hs_0049736
TUBA1B
tubulin, alpha 1b
−1.58
4.408E−06
10376

PH_hs_0016555
FDX1L
ferredoxin 1-like
−1.58
6.643E−07
112812

PH_hs_0032775
FAM102A
family with sequence similarity 102, member A
−1.58
1.105E−02
399665

PH_hs_0004360
STX1A
syntaxin 1A (brain)
−1.58
5.134E−04
6804

PH_hs_0047441
STC2
stanniocalcin 2
−1.58
4.336E−04
8614

PH_hs_0042579
OR9G4
olfactory receptor, family 9, subfamily G, member 4
−1.58
1.585E−03
283189

PH_hs_0005496
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
−1.58
6.247E−06
1051

PH_hs_0000972
TPX2
TPX2, microtubule-associated, homolog (Xenopus laevis)
−1.58
7.974E−07
22974

PH_hs_0030976
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
−1.58
1.258E−02
4793

PH_hs_0025894
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
−1.58
6.282E−04
5717

PH_hs_0035995
IDH3B
isocitrate dehydrogenase 3 (NAD+) beta
−1.58
4.342E−03
3420

PH_hs_0016737
RNFT2
ring finger protein, transmembrane 2
−1.58
3.709E−05
84900

PH_hs_0029014
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
−1.58
5.940E−08
5691

PH_hs_0022722
XPQ1
exportin 1 (CRM1 homolog, yeast)
−1.58
2.317E−03
7514

PH_hs_0017273
CCDC80
coiled-coil domain containing 80
−1.58
4.779E−03
151887

PH_hs_0034252
GBA
glucosidase, beta, acid
−1.58
6.789E−05
2629

PH_hs_0045439
U2AF1
U2 small nuclear RNA auxiliary factor 1
−1.58
5.021E−04
7307

PH_hs_0042037
KIF5B
kinesin family member 5B
−1.57
8.342E−04
3799

PH_hs_0033649
C6orf191
chromosome 6 open reading frame 191
−1.57
3.539E−02
253582

PH_hs_0043455
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
−1.57
4.900E−06
91368

PH_hs_0000774
ATP6V0B
ATPase, H+ transporting, lysosomal 21 kDa, V0 subunit b
−1.57
5.481E−07
533

PH_hs_0014714
GPN3
GPN-loop GTPase 3
−1.57
7.778E−04
51184

PH_hs_0048167
TGOLN2
trans-golgi network protein 2
−1.57
8.987E−03
10618

PH_hs_0003647
MRPL51
mitochondrial ribosomal protein L51
−1.57
1.079E−06
51258

PH_hs_0000084
IER2
immediate early response 2
−1.57
3.085E−03
9592

PH_hs_0006093
DEK
DEK oncogene
−1.57
4.785E−05
7913

PH_hs_0049458
ZNF367
zinc finger protein 367
−1.57
8.118E−06
195828

PH_hs_0045731
GAS6
growth arrest-specific 6
−1.57
2.941E−03
2621

PH_hs_0042627
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
−1.57
4.076E−04
3291

PH_hs_0045021
AK2
adenylate kinase 2
−1.57
1.179E−09
204

PH_hs_0019487
SCN1B
sodium channel, voltage-gated, type I, beta
−1.57
9.110E−06
6324

PH_hs_0031022
SNRNP25
small nuclear ribonucleoprotein 25 kDa (U11/U12)
−1.56
3.507E−04
79622

PH_hs_0036212
PREPL
prolyl endopeptidase-like
−1.56
1.834E−05
9581

PH_hs_0047598
SKA2
spindle and kinetochore associated complex subunit 2
−1.56
4.366E−04
348235

PH_hs_0042314
ITGB1BP3
integrin beta 1 binding protein 3
−1.56
2.862E−04
27231

PH_hs_0028818
FAM132B
family with sequence similarity 132, member B
−1.56
1.320E−02
151176

PH_hs_0001900
TCEAL7
transcription elongation factor A (SII)-like 7
−1.56
3.320E−08
56849

PH_hs_0002232
IRX5
iroquois homeobox 5
−1.56
1.028E−02
10265

PH_hs_0005745
DNASE1L2
deoxyribonuclease 1-like 2
−1.56
1.675E−02
1775

PH_hs_0009654
RHEBL1
Ras homolog enriched in brain like 1
−1.56
1.015E−03
121268

PH_hs_0023170
COL6A3
collagen, type VI, alpha 3
−1.56
5.901E−05
1293

PH_hs_0012740
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
−1.56
6.334E−05
3181

PH_hs_0045185
APITD1|APITD1-
apoptosis-inducing, TAF9-like domain 1|APITD1-CORT read-through
−1.56
1.837E−02
378708|1005267

CORT

39

PH_hs_0019597
SLC31A1
solute carrier family 31 (copper transporters), member 1
−1.56
1.821E−05
1317

PH_hs_0004640
MVP
major vault protein
−1.56
4.294E−03
9961

PH_hs_0009331
BCL6
B-cell CLL/lymphoma 6
−1.56
1.401E−05
604

PH_hs_0047504
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
−1.56
1.386E−02
206358

PH_hs_0033324
PDK1
pyruvate dehydrogenase kinase, isozyme 1
−1.56
1.322E−02
5163

PH_hs_0016208
WDR87
WD repeat domain 87
−1.56
4.877E−03
83889

PH_hs_0025539
NOM1
nucleolar protein with MIF4G domain 1
−1.56
1.313E−03
64434

PH_hs_0044231
TMEM205
transmembrane protein 205
−1.56
8.953E−08
374882

PH_hs_0043161
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
−1.56
5.915E−03
84154

PH_hs_0027173
GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
−1.56
2.280E−08
90480

PH_hs_0009338
GNB5
guanine nucleotide binding protein (G protein), beta 5
−1.56
3.405E−03
10681

PH_hs_0001609
ORC1
origin recognition complex, subunit 1
−1.56
1.568E−03
4998

PH_hs_0025441
IGFBP7
insulin-like growth factor binding protein 7
−1.56
1.101E−04
3490

PH_hs_0045832
SCML1
sex comb on midleg-like 1 (Drosophila)
−1.55
1.960E−03
6322

PH_hs_0027330
ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
−1.55
2.179E−04
3675

PH_hs_0004485
KNG1
kininogen 1
−1.55
1.097E−03
3827

PH_hs_0043371
DYNLT3
dynein, light chain, Tctex-type 3
−1.55
1.062E−03
6990

PH_hs_0042113
TDP2
tyrosyl-DNA phosphodiesterase 2
−1.55
1.367E−05
51567

PH_hs_0048414
LYPD1
LY6/PLAUR domain containing 1
−1.55
4.586E−06
116372

PH_hs_0043504
PRKD2
protein kinase D2
−1.55
3.743E−02
25865

PH_hs_0029970
RPL21|RPL21P28
ribosomal protein L21|ribosomal protein L21 pseudogene 28
−1.55
1.545E−05
6144|100131205

PH_hs_0024955
NUP205
nucleoporin 205 kDa
−1.55
2.455E−04
23165

PH_hs_0034691
RPSAP58|RPSA
ribosomal protein SA pseudogene 58|ribosomal protein SA
−1.55
1.644E−07
388524|3921

PH_hs_0042301
FAM184B
family with sequence similarity 184, member B
−1.55
2.543E−03
27146

PH_hs_0032176
KIAA1715
KIAA1715
−1.55
1.243E−05
80856

PH_hs_0045064
ASCC3
activating signal cointegrator 1 complex subunit 3
−1.55
1.377E−04
10973

PH_hs_0028321
WDR5
WD repeat domain 5
−1.55
2.593E−03
11091

PH_hs_0000362
NDP
Norrie disease (pseudoglioma)
−1.55
1.991E−02
4693

PH_hs_0036525
LOC723972
hepatopoietin PCn127
−1.55
5.314E−03
723972

PH_hs_0042371
SRM
spermidine synthase
−1.55
8.957E−05
6723

PH_hs_0043178
MED25
mediator complex subunit 25
−1.55
1.898E−08
81857

PH_hs_0012275
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
−1.55
4.993E−04
7128

PH_hs_0002364
FAM108C1
family with sequence similarity 108, member C1
−1.55
1.195E−04
58489

PH_hs_0023879
BCCIP
BRCA2 and CDKN1A interacting protein
−1.55
3.503E−05
56647

PH_hs_0026052
CD63
CD63 molecule
−1.55
7.081E−04
967

PH_hs_0023309
PNO1
partner of NOB1 homolog (S. cerevisiae)
−1.55
2.375E−07
56902

PH_hs_0005994
POLE3
polymerase (DNA directed), epsilon 3 (p17 subunit)
−1.55
5.996E−05
54107

PH_hs_0042994
C17orf89
chromosome 17 open reading frame 89
−1.54
2.443E−06
284184

PH_hs_0023297
FEZ2
fasciculation and elongation protein zeta 2 (zygin II)
−1.54
3.770E−08
9637

PH_hs_0028985
UCHL3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
−1.54
1.460E−02
7347

PH_hs_0023515
DCTN2
dynactin 2 (p50)
−1.54
4.633E−04
10540

PH_hs_0031357
MMD
monocyte to macrophage differentiation-associated
−1.54
2.163E−02
23531

PH_hs_0044653
FZR1
fizzy/cell division cycle 20 related 1 (Drosophila)
−1.54
6.402E−03
51343

PH_hs_0029801
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
−1.54
5.075E−06
3516

PH_hs_0001441
ZCCHC9
zinc finger, CCHC domain containing 9
−1.54
4.844E−02
84240

PH_hs_0044663
PDE7A
phosphodiesterase 7A
−1.54
6.506E−04
5150

PH_hs_0042297
LOC728024
chromosome X open reading frame 56 pseudogene
−1.54
2.346E−03
728024

PH_hs_0036053
HNRNPA1P10|HNR
heterogeneous nuclear ribonucleoprotein A1 pseudogene 10|heterogeneous nuclear ribonucleoprotein A1-like 2
−1.54
2.367E−04
664709|144983

NPA1L2

PH_hs_0004152
ALKBH3
alkB, alkylation repair homolog 3 (E. coli)
−1.54
4.653E−04
221120

PH_hs_0001032
EMP3
epithelial membrane protein 3
−1.54
5.502E−03
2014

PH_hs_0007357
HDGFRP3
hepatoma-derived growth factor, related protein 3
−1.54
3.829E−04
50810

PH_hs_0025796
DDX1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
−1.54
2.149E−05
1653

PH_hs_0005643
MAST2
microtubule associated serine/threonine kinase 2
−1.54
1.655E−04
23139

PH_hs_0044106
C7orf44
chromosome 7 open reading frame 44
−1.54
1.777E−02
55744

PH_hs_0005844
AIM2
absent in melanoma 2
−1.54
1.492E−05
9447

PH_hs_0003453
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
−1.54
1.379E−03
55075

PH_hs_0024767
MAPRE1
microtubule-associated protein, RP/EB family, member 1
−1.54
1.001E−06
22919

PH_hs_0026523
LAT
linker for activation of T cells
−1.54
2.833E−05
27040

PH_hs_0030224
LBR
lamin B receptor
−1.54
7.940E−04
3930

PH_hs_0016124
CD82
CD82 molecule
−1.54
7.113E−04
3732

PH_hs_0047488
RTTN
rotatin
−1.54
8.024E−04
25914

PH_hs_0045751
PRMT1
protein arginine methyltransferase 1
−1.54
5.335E−03
3276

PH_hs_0014950
ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
−1.53
5.043E−03
10610

PH_hs_0042237
ASAM
adipocyte-specific adhesion molecule
−1.53
2.390E−02
79827

PH_hs_0010045
TCTN2
tectonic family member 2
−1.53
2.124E−02
79867

PH_hs_0005616
CEP72
centrosomal protein 72 kDa
−1.53
7.808E−04
55722

PH_hs_0040108
MRPS7
mitochondrial ribosomal protein S7
−1.53
1.221E−05
51081

PH_hs_0043151
TMEM126B
transmembrane protein 126B
−1.53
2.268E−03
55863

PH_hs_0031377
SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
−1.53
2.405E−02
6612

PH_hs_0027070
CANT1
calcium activated nucleotidase 1
−1.53
2.427E−09
124583

PH_hs_0003940
GOLT1B
golgi transport 1B
−1.53
2.734E−03
51026

PH_hs_0003882
PSMC2
proteasome (prosome, macropain) 26S subunit, ATPase, 2
−1.53
2.074E−04
5701

PH_hs_0042349
UBE2S
ubiquitin-conjugating enzyme E2S
−1.53
1.020E−04
27338

PH_hs_0033920
RPS2|RPS2P32
ribosomal protein S2|ribosomal protein S2 pseudogene 32
−1.53
2.014E−04
6187|256355

PH_hs_0035967
SEPW1
selenoprotein W, 1
−1.53
8.249E−07
6415

PH_hs_0013492
C19orf48
chromosome 19 open reading frame 48
−1.53
3.217E−02
84798

PH_hs_0024307
RABGAP1L
RAB GTPase activating protein 1-like
−1.53
1.971E−06
9910

PH_hs_0014633
RELL1
RELT-like 1
−1.53
1.784E−04
768211

PH_hs_0048556
ABI2
abl-interactor 2
−1.53
2.139E−02
10152

PH_hs_0042396
CCDC55
coiled-coil domain containing 55
−1.53
1.609E−03
84081

PH_hs_0025941
EZH2
enhancer of zeste homolog 2 (Drosophila)
−1.53
5.642E−04
2146

PH_hs_0042302
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
−1.53
2.838E−03
9603

PH_hs_0048073
MID1
midline 1 (Opitz/BBB syndrome)
−1.53
6.308E−05
4281

PH_hs_0045238
POMZP3
POM121 and ZP3 fusion
−1.53
3.140E−02
22932

PH_hs_0006055
C6orf108
chromosome 6 open reading frame 108
−1.53
2.161E−05
10591

PH_hs_0001067
ADPGK
ADP-dependent glucokinase
−1.53
1.636E−03
83440

PH_hs_0048983
UGT8
UDP glycosyltransferase 8
−1.53
5.934E−06
7368

PH_hs_0014217
TRIML2
tripartite motif family-like 2
−1.53
3.721E−02
205860

PH_hs_0022450
ACP1
acid phosphatase 1, soluble
−1.53
1.088E−05
52

PH_hs_0038578
TPI1P2
triosephosphate isomerase 1 pseudogene 2
−1.52
3.335E−04
286016

PH_hs_0028259
TUBGCP2
tubulin, gamma complex associated protein 2
−1.52
4.195E−03
10844

PH_hs_0022623
ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
−1.52
4.213E−02
479

PH_hs_0001474
C2CD2
C2 calcium-dependent domain containing 2
−1.52
5.457E−03
25966

PH_hs_0024635
DHX29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
−1.52
2.895E−02
54505

PH_hs_0046144
SLC22A23
solute carrier family 22, member 23
−1.52
1.474E−06
63027

PH_hs_0042374
SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
−1.52
1.375E−04
9789

PH_hs_0049062
PTPRE
protein tyrosine phosphatase, receptor type, E
−1.52
1.076E−02
5791

PH_hs_0004268
TSN
translin
−1.52
3.016E−04
7247

PH_hs_0044174
CCDC34
coiled-coil domain containing 34
−1.52
1.696E−05
91057

PH_hs_0000095
HNRNPF
heterogeneous nuclear ribonucleoprotein F
−1.52
9.856E−03
3185

PH_hs_0047557
SMG1
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
−1.52
4.786E−03
23049

PH_hs_0001034
MRPL17
mitochondrial ribosomal protein L17
−1.52
1.608E−02
63875

PH_hs_0028767
ZNF205
zinc finger protein 205
−1.52
6.249E−04
7755

PH_hs_0024960
MAPKAPK5
mitogen-activated protein kinase-activated protein kinase 5
−1.52
1.010E−02
8550

PH_hs_0048097
WNK1
WNK lysine deficient protein kinase 1
−1.52
9.225E−04
65125

PH_hs_0045887
EDF1
endothelial differentiation-related factor 1
−1.52
3.984E−06
8721

PH_hs_0022899
RBBP6
retinoblastoma binding protein 6
−1.52
3.670E−02
5930

PH_hs_0026178
RHOV
ras homolog gene family, member V
−1.52
9.963E−04
171177

PH_hs_0047826
GNA12
guanine nucleotide binding protein (G protein) alpha 12
−1.52
5.094E−05
2768

PH_hs_0043828
RAB28
RAB28, member RAS oncogene family
−1.52
3.772E−08
9364

PH_hs_0001647
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
−1.52
1.093E−02
8476

PH_hs_0036173
PHLDA1
pleckstrin homology-like domain, family A, member 1
−1.52
6.756E−03
22822

PH_hs_0014144
IGFBP6
insulin-like growth factor binding protein 6
−1.51
1.443E−04
3489

PH_hs_0002729
RAB32
RAB32, member RAS oncogene family
−1.51
3.247E−07
10981

PH_hs_0024838
HOMER3
homer homolog 3 (Drosophila)
−1.51
1.595E−06
9454

PH_hs_0004294
CHAF1B
chromatin assembly factor 1, subunit B (p60)
−1.51
1.896E−04
8208

PH_hs_0019868
NUDT2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
−1.51
2.029E−04
318

PH_hs_0048583
ARSB
arylsulfatase B
−1.51
7.077E−03
411

PH_hs_0026399
WSB2
WD repeat and SOCS box-containing 2
−1.51
3.959E−04
55884

PH_hs_0009365
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
−1.51
7.727E−04
8729

PH_hs_0002134
EML2
echinoderm microtubule associated protein like 2
−1.51
6.098E−05
24139

PH_hs_0004460
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
−1.51
1.066E−03
5355

PH_hs_0016002
OSBPL6
oxysterol binding protein-like 6
−1.51
3.213E−04
114880

PH_hs_0040227
CCT2
chaperonin containing TCP1, subunit 2 (beta)
−1.51
1.726E−03
10576

PH_hs_0043346
MMS22L
MMS22-like, DNA repair protein
−1.51
5.604E−03
253714

PH_hs_0043854
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
−1.51
5.534E−03
7534

PH_hs_0028426
CPSF2
cleavage and polyadenylation specific factor 2, 100 kDa
−1.51
3.959E−05
53981

PH_hs_0003307
IFFO1
intermediate filament family orphan 1
−1.51
3.000E−03
25900

PH_hs_0002624
C1orf183
chromosome 1 open reading frame 183
−1.51
2.437E−02
55924

PH_hs_0043283
AVL9
AVL9 homolog (S. cerevisiase)
−1.51
5.360E−03
23080

PH_hs_0002454
STK32C
serine/threonine kinase 32C
−1.51
1.680E−03
282974

PH_hs_0023205
NACC2
NACC family member 2, BEN and BTB (POZ) domain containing
−1.51
4.284E−05
138151

PH_hs_0022730
AARS2
alanyl-tRNA synthetase 2, mitochondrial (putative)
−1.51
8.329E−04
57505

PH_hs_0022481
SLC38A1
solute carrier family 38, member 1
−1.51
8.055E−03
81539

PH_hs_0011979
HELLS
helicase, lymphoid-specific
−1.51
5.647E−05
3070

PH_hs_0023943
DYNC1LI1
dynein, cytoplasmic 1, light intermediate chain 1
−1.51
2.582E−07
51143

PH_hs_0048423
MTHFD2L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
−1.51
2.343E−05
441024

PH_hs_0043722
HSPE1
heat shock 10 kDa protein 1 (chaperonin 10)
−1.50
1.243E−05
3336

PH_hs_0046245
RN7SK
RNA, 7SK small nuclear
−1.50
7.331E−03
125050

PH_hs_0042076
MND1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
−1.50
8.546E−04
84057

PH_hs_0033252
CCT8
chaperonin containing TCP1, subunit 8 (theta)
−1.50
4.221E−04
10694

PH_hs_0017250
MRPL52
mitochondrial ribosomal protein L52
−1.50
1.191E−04
122704

PH_hs_0004748
CRYZ
crystallin, zeta (quinone reductase)
−1.50
1.292E−04
1429

PH_hs_0048353
DGKG
diacylglycerol kinase, gamma 90 kDa
−1.50
4.838E−03
1608

PH_hs_0016106
WDR54
WD repeat domain 54
−1.50
8.701E−07
84058

PH_hs_0014646
CENPN
centromere protein N
−1.50
3.810E−04
55839

PH_hs_0046162
ZNF655
zinc finger protein 655
−1.50
5.230E−03
79027

PH_hs_0042329
C14orf129
chromosome 14 open reading frame 129
−1.50
1.286E−02
51527

PH_hs_0027429
PGD
phosphogluconate dehydrogenase
1.50
1.210E−02
5226

PH_hs_0043881
PAIP1
poly(A) binding protein interacting protein 1
1.50
2.633E−04
10605

PH_hs_0045400
CLYBL
citrate lyase beta like
1.50
4.115E−05
171425

PH_hs_0043595
CD2BP2
CD2 (cytoplasmic tail) binding protein 2
1.50
1.797E−05
10421

PH_hs_0048644
UBFD1
ubiquitin family domain containing 1
1.50
1.980E−04
56061

PH_hs_0047552
PHF20L1
PHD finger protein 20-like 1
1.50
1.004E−04
51105

PH_hs_0026183
GGN
gametogenetin
1.50
5.191E−03
199720

PH_hs_0003403
SCFD2
seel family domain containing 2
1.50
1.088E−02
152579

PH_hs_0048448
CTSC
cathepsin C
1.50
4.601E−04
1075

PH_hs_0024651
KIAA0564
KIAA0564
1.50
2.283E−02
23078

PH_hs_0003439
BACE1
beta-site APP-cleaving enzyme 1
1.50
1.051E−05
23621

PH_hs_0043807
SNORD36C
small nucleolar RNA, C/D box 36C
1.50
2.005E−02
26813

PH_hs_0006004
APH1A
anterior pharynx defective 1 homolog A (C. elegans)
1.50
4.814E−07
51107

PH_hs_0048482
RNF41
ring finger protein 41
1.51
3.158E−04
10193

PH_hs_0025673
POLI
polymerase (DNA directed) iota
1.51
7.395E−05
11201

PH_hs_0016735
MTMR1
myotubularin related protein 1
1.51
1.677E−03
8776

PH_hs_0047917
ZNF22
zinc finger protein 22 (KOX 15)
1.51
8.036E−05
7570

PH_hs_0013712
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
1.51
3.284E−04
55640

PH_hs_0043122
C8orf58
chromosome 8 open reading frame 58
1.51
1.542E−02
541565

PH_hs_0004469
COX10
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
1.51
1.901E−05
1352

PH_hs_0032150
ACO2
aconitase 2, mitochondrial
1.51
3.217E−05
50

PH_hs_0002405
LOC728769
hypothetical LOC728769
1.51
2.871E−04
728769

PH_hs_0047565
SCAI
suppressor of cancer cell invasion
1.51
4.964E−02
286205

PH_hs_0020536
PCNXL2
pecanex-like 2 (Drosophila)
1.51
8.610E−04
80003

PH_hs_0004941
LYPLAL1
lysophospholipase-like 1
1.51
3.513E−05
127018

PH_hs_0004372
PDLIM1
PDZ and LIM domain 1
1.51
1.027E−10
9124

PH_hs_0001012
NDFIP1
Nedd4 family interacting protein 1
1.51
8.944E−06
80762

PH_hs_0000383
ZBTB6
zinc finger and BTB domain containing 6
1.51
1.593E−04
10773

PH_hs_0038333
CD3D
CD3d molecule, delta (CD3-TCR complex)
1.51
6.190E−03
915

PH_hs_0014077
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
1.51
3.067E−04
5530

PH_hs_0023907
LOC729678
hypothetical LOC729678
1.51
7.940E−04
729678

PH_hs_0010397
LRRC8A
leucine rich repeat containing 8 family, member A
1.51
7.358E−07
56262

PH_hs_0010861
ASPHD2
aspartate beta-hydroxylase domain containing 2
1.51
2.650E−04
57168

PH_hs_0003128
CWC15
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
1.51
9.358E−03
51503

PH_hs_0000400
HSPA6|HSPA7
heat shock 70 kDa protein 6 (HSP70B′)|heat shock 70 kDa protein 7 (HSP70B)
1.51
3.097E−04
3310|3311

PH_hs_0001871
AGTPBP1
ATP/GTP binding protein 1
1.51
9.026E−03
23287

PH_hs_0000185
EGR2
early growth response 2
1.51
6.131E−03
1959

PH_hs_0024220
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
1.51
7.994E−04
9459

PH_hs_0006447
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
1.51
2.535E−02
6580

PH_hs_0005008
TKT
transketolase
1.51
1.316E−05
7086

PH_hs_0048391
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
1.52
3.244E−05
8658

PH_hs_0004304
UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
1.52
2.617E−06
9354

PH_hs_0048671
RSL1D1
ribosomal L1 domain containing 1
1.52
4.283E−07
26156

PH_hs_0048540
PPAPDC1B
phosphatidic acid phosphatase type 2 domain containing 1B
1.52
5.595E−05
84513

PH_hs_0016168
TBC1D17
TBC1 domain family, member 17
1.52
1.279E−04
79735

PH_hs_0015637
KCTD10
potassium channel tetramerisation domain containing 10
1.52
1.879E−05
83892

PH_hs_0023033
SPTBN1
spectrin, beta, non-erythrocytic 1
1.52
6.840E−03
6711

PH_hs_0016601
MYLK3
myosin light chain kinase 3
1.52
2.776E−02
91807

PH_hs_0045413
ISPD
isoprenoid synthase domain containing
1.52
3.156E−03
729920

PH_hs_0001800
PCBP4
poly(rC) binding protein 4
1.52
1.341E−03
57060

PH_hs_0018078
ZNF433
zinc finger protein 433
1.52
1.872E−03
163059

PH_hs_0004727
THAP11
THAP domain containing 11
1.52
3.289E−02
57215

PH_hs_0045886
ABCC3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
1.52
4.111E−02
8714

PH_hs_0048645
JMJD6
jumonji domain containing 6
1.52
4.753E−03
23210

PH_hs_0004786
EFR3A
EFR3 homolog A (S. cerevisiae)
1.52
5.120E−03
23167

PH_hs_0024084
GMPR2
guanosine monophosphate reductase 2
1.52
1.927E−02
51292

PH_hs_0022118
TSPAN6
tetraspanin 6
1.52
8.438E−08
7105

PH_hs_0024849
SMAP1
small ArfGAP 1
1.52
8.788E−06
60682

PH_hs_0000168
BMP1
bone morphogenetic protein 1
1.52
2.780E−02
649

PH_hs_0042131
UNC5B
unc-5 homolog B (C. elegans)
1.52
6.477E−05
219699

PH_hs_0004107
HMG20A
high-mobility group 20A
1.52
3.115E−04
10363

PH_hs_0005691
DCAF12
DDB1 and CUL4 associated factor 12
1.52
2.355E−05
25853

PH_hs_0048600
FAM83A
family with sequence similarity 83, member A
1.52
6.789E−03
84985

PH_hs_0032001
C4orf3
chromosome 4 open reading frame 3
1.53
8.890E−03
401152

PH_hs_0001041
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
1.53
5.645E−03
4298

PH_hs_0009558
MOCOS
molybdenum cofactor sulfurase
1.53
8.519E−03
55034

PH_hs_0025759
PINK1
PTEN induced putative kinase 1
1.53
8.950E−03
65018

PH_hs_0048966
TET2
tet oncogene family member 2
1.53
3.614E−05
54790

PH_hs_0043745
ERGIC3
ERGIC and golgi 3
1.53
1.094E−04
51614

PH_hs_0004918
ALDH3B2
aldehyde dehydrogenase 3 family, member B2
1.53
1.294E−04
222

PH_hs_0000975
CRELD1
cysteine-rich with EGF-like domains 1
1.53
1.854E−03
78987

PH_hs_0000785
C19orf25
chromosome 19 open reading frame 25
1.53
3.172E−05
148223

PH_hs_0018872
PRRC2B
proline-rich coiled-coil 2B
1.53
1.716E−02
84726

PH_hs_0015541
ZNF688
zinc finger protein 688
1.53
1.740E−02
146542

PH_hs_0025301
PREP
prolyl endopeptidase
1.53
3.247E−02
5550

PH_hs_0024410
FBXO18
F-box protein, helicase, 18
1.53
1.225E−02
84893

PH_hs_0046233
PWWP2A
PWWP domain containing 2A
1.53
4.429E−05
114825

PH_hs_0049034
PRRC1
proline-rich coiled-coil 1
1.53
4.088E−06
133619

PH_hs_0046198
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
1.53
2.960E−03
84078

PH_hs_0030171
HIGD2A|LOC10050
HIG1 hypoxia inducible domain family, member 2A|HIG1 domain family member 2A-like
1.53
2.577E−04
192286|1005066

6614

14

PH_hs_0022591
METAP2
methionyl aminopeptidase 2
1.53
4.749E−04
10988

PH_hs_0042234
AVEN
apoptosis, caspase activation inhibitor
1.53
8.367E−05
57099

PH_hs_0048476
LOC284023
hypothetical LOC284023
1.53
1.885E−04
284023

PH_hs_0025536
FAP
fibroblast activation protein, alpha
1.53
1.381E−03
2191

PH_hs_0004756
C7orf36
chromosome 7 open reading frame 36
1.53
1.277E−06
57002

PH_hs_0044296
EIF4E2
eukaryotic translation initiation factor 4E family member 2
1.53
1.536E−03
9470

PH_hs_0025084
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
1.53
8.645E−05
9815

PH_hs_0044758
N4BP2L2
NEDD4 binding protein 2-like 2
1.53
2.744E−03
10443

PH_hs_0049234
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
1.53
1.215E−04
55187

PH_hs_0000638
NAV1
neuron navigator 1
1.53
1.732E−04
89796

PH_hs_0009353
ALDOC
aldolase C, fructose-bisphosphate
1.53
7.378E−04
230

PH_hs_0010455
TMEM41B
transmembrane protein 41B
1.53
3.761E−04
440026

PH_hs_0027444
TMEM183A|TMEM1
transmembrane protein 183A|transmembrane protein 183B
1.53
8.395E−08
92703|653659

83B

PH_hs_0035954
COX6B1
cytochrome c oxidase subunit Vlb polypeptide 1 (ubiquitous)
1.54
5.741E−06
1340

PH_hs_0047622
PLEKHA2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
1.54
4.550E−04
59339

PH_hs_0027276
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220 kDa
1.54
1.208E−05
5430

PH_hs_0016038
SAMD14
sterile alpha motif domain containing 14
1.54
4.183E−03
201191

PH_hs_0049628
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
1.54
2.288E−04
10049

PH_hs_0048596
FBXW11
F-box and WD repeat domain containing 11
1.54
3.613E−06
23291

PH_hs_0044398
KIAA0319L
KIAA0319-like
1.54
6.188E−07
79932

PH_hs_0020045
EXOSC6
exosome component 6
1.54
1.294E−05
118460

PH_hs_0000767
TFB2M
transcription factor B2, mitochondrial
1.54
2.152E−07
64216

PH_hs_0034852
PCYT2
phosphate cytidylyltransferase 2, ethanolamine
1.54
5.404E−04
5833

PH_hs_0033414
DOCK1
dedicator of cytokinesis 1
1.54
1.046E−03
1793

PH_hs_0043219
FAM49B
family with sequence similarity 49, member B
1.54
3.796E−05
51571

PH_hs_0033727
UBE2E3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
1.54
1.087E−04
10477

PH_hs_0047945
PDE4D
phosphodiesterase 4D, cAMP-specific
1.54
8.361E−03
5144

PH_hs_0009339
CA2
carbonic anhydrase II
1.54
7.809E−04
760

PH_hs_0047971
ZC3H4
zinc finger CCCH-type containing 4
1.54
2.618E−04
23211

PH_hs_0049011
GRIP1
glutamate receptor interacting protein 1
1.54
1.326E−04
23426

PH_hs_0032559
GCN1L1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
1.54
1.606E−03
10985

PH_hs_0010814
NOL6
nucleolar protein family 6 (RNA-associated)
1.54
3.008E−05
65083

PH_hs_0005005
PTHLH
parathyroid hormone-like hormone
1.54
1.241E−03
5744

PH_hs_0030094
LGALS3
lectin, galactoside-binding, soluble, 3
1.54
1.676E−06
3958

PH_hs_0029625
B3GALT6
UDP-Gal: betaGal beta 1,3-galactosyltransferase polypeptide 6
1.55
1.468E−04
126792

PH_hs_0022323
ST5
suppression of tumorigenicity 5
1.55
7.224E−05
6764

PH_hs_0009186
GBAS
glioblastoma amplified sequence
1.55
2.304E−04
2631

PH_hs_0023193
PLEKHA5
pleckstrin homology domain containing, family A member 5
1.55
1.799E−03
54477

PH_hs_0004643
PCCA
propionyl CoA carboxylase, alpha polypeptide
1.55
9.936E−08
5095

PH_hs_0000531
GMFG
glia maturation factor, gamma
1.55
1.651E−03
9535

PH_hs_0002963
C18orf21
chromosome 18 open reading frame 21
1.55
5.907E−03
83608

PH_hs_0047295
KLHL7
kelch-like 7 (Drosophila)
1.55
1.097E−05
55975

PH_hs_0008777
C1orf123
chromosome 1 open reading frame 123
1.55
6.129E−07
54987

PH_hs_0045514
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
1.55
7.689E−05
522

PH_hs_0004522
ZNF133
zinc finger protein 133
1.55
2.580E−06
7692

PH_hs_0025950
POU2F1
POD class 2 homeobox 1
1.55
2.104E−02
5451

PH_hs_0019788
LOC100128239
hypothetical LOC100128239
1.55
5.510E−04
100128239

PH_hs_0048539
BIRC6
baculoviral IAP repeat-containing 6
1.55
2.960E−05
57448

PH_hs_0010855
FBXO21
F-box protein 21
1.55
1.943E−05
23014

PH_hs_0039715
EIF2AK1
eukaryotic translation initiation factor 2-alpha kinase 1
1.55
1.187E−04
27102

PH_hs_0049257
MEF2A
myocyte enhancer factor 2A
1.55
4.262E−04
4205

PH_hs_0024999
SFRS18
splicing factor, arginine/serine-rich 18
1.55
2.577E−03
25957

PH_hs_0028746
EBAG9
estrogen receptor binding site associated, antigen, 9
1.55
4.614E−08
9166

PH_hs_0048431
LUZP1
leucine zipper protein 1
1.55
4.034E−05
7798

PH_hs_0036083
HIST1H2BO
histone cluster 1, H2bo
1.55
9.118E−03
8348

PH_hs_0016039
ZNRF1
zinc and ring finger 1
1.55
7.343E−03
84937

PH_hs_0042922
LYRM5
LYR motif containing 5
1.55
1.915E−06
144363

PH_hs_0048199
TMEM120B
transmembrane protein 120B
1.55
8.962E−05
144404

PH_hs_0049208
RAB3GAP2
RAB3 GTPase activating protein subunit 2 (non-catalytic)
1.55
2.390E−08
25782

PH_hs_0022563
CASP3
caspase 3, apoptosis-related cysteine peptidase
1.55
3.907E−06
836

PH_hs_0042429
FDX1
ferredoxin 1
1.56
8.693E−04
2230

PH_hs_0005685
NTN4
netrin 4
1.56
2.472E−03
59277

PH_hs_0024939
ARHGAP18
Rho GTPase activating protein 18
1.56
6.715E−04
93663

PH_hs_0031479
ZNF12
zinc finger protein 12
1.56
1.858E−06
7559

PH_hs_0043827
SSBP3
single stranded DNA binding protein 3
1.56
8.140E−05
23648

PH_hs_0049288
OPTN
optineurin
1.56
9.636E−04
10133

PH_hs_0000824
AFTPH
aftiphilin
1.56
1.799E−06
54812

PH_hs_0049396
C19orf12
chromosome 19 open reading frame 12
1.56
1.255E−02
83636

PH_hs_0048450
CSRNP2
cysteine-serine-rich nuclear protein 2
1.56
6.262E−05
81566

PH_hs_0047426
TTBK2
tau tubulin kinase 2
1.56
1.531E−04
146057

PH_hs_0004351
CD58
CD58 molecule
1.56
6.131E−03
965

PH_hs_0009296
SS18L1
synovial sarcoma translocation gene on chromosome 18-like 1
1.56
8.882E−05
26039

PH_hs_0025428
ATAD1
ATPase family, AAA domain containing 1
1.56
2.530E−02
84896

PH_hs_0048165
HUWE1
HECT, UBA and WWE domain containing 1
1.56
4.140E−02
10075

PH_hs_0049522
GCOM1|GRINL1A
GRINL1A complex locus|glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
1.56
1.726E−07
145781181488

PH_hs_0026865
IQCG
IQ motif containing G
1.56
3.815E−05
84223

PH_hs_0049719
ZNF286A|ZNF286B
zinc finger protein 286A|zinc finger protein 286B
1.56
1.631E−07
57335|729288

PH_hs_0032018
C14orf4
chromosome 14 open reading frame 4
1.56
3.766E−02
64207

PH_hs_0024650
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine: polypeptide-N-acetylglucosaminyl
1.56
2.950E−06
8473

transferase)

PH_hs_0017245
GPT2
glutamic pyruvate transaminase (alanine aminotransferase) 2
1.56
1.058E−07
84706

PH_hs_0032724
RHPN2
rhophilin, Rho GTPase binding protein 2
1.56
8.249E−03
85415

PH_hs_0045351
CSNK1A1
casein kinase 1, alpha 1
1.57
1.154E−02
1452

PH_hs_0048038
MAVS
mitochondrial antiviral signaling protein
1.57
1.928E−02
57506

PH_hs_0004369
GTF3C2
general transcription factor IIIC, polypeptide 2, beta 110 kDa
1.57
2.550E−05
2976

PH_hs_0012636
C12orf59
chromosome 12 open reading frame 59
1.57
5.695E−04
120939

PH_hs_0027047
PSEN1
presenilin 1
1.57
6.207E−08
5663

PH_hs_0025563
POLG2
polymerase (DNA directed), gamma 2, accessory subunit
1.57
4.194E−02
11232

PH_hs_0044185
SC4MOL
sterol-C4-methyl oxidase-like
1.57
4.298E−05
6307

PH_hs_0049284
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
1.57
1.170E−04
23704

PH_hs_0033019
CLEC16A
C-type lectin domain family 16, member A
1.57
2.175E−04
23274

PH_hs_0004621
G6PD
glucose-6-phosphate dehydrogenase
1.57
4.259E−11
2539

PH_hs_0008936
CNFN
cornifelin
1.57
2.439E−03
84518

PH_hs_0011767
SCAMP3
secretory carrier membrane protein 3
1.57
9.620E−04
10067

PH_hs_0016122
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
1.57
2.182E−04
6509

PH_hs_0022142
TTC39B
tetratricopeptide repeat domain 39B
1.57
4.096E−02
158219

PH_hs_0045419
C3orf74
chromosome 3 open reading frame 74
1.57
9.866E−04
100128378

PH_hs_0030874
SRGN
serglycin
1.57
1.624E−04
5552

PH_hs_0048143
CCDC28A
coiled-coil domain containing 28A
1.58
9.407E−04
25901

PH_hs_0044123
C11orf1
chromosome 11 open reading frame 1
1.58
1.074E−05
64776

PH_hs_0004165
TBC1D14
TBC1 domain family, member 14
1.58
1.030E−04
57533

PH_hs_0002175
SH3D19
SH3 domain containing 19
1.58
7.045E−06
152503

PH_hs_0024840
UBR5
ubiquitin protein ligase E3 component n-recognin 5
1.58
2.780E−03
51366

PH_hs_0022141
AMACR
alpha-methylacyl-CoA racemase
1.58
4.171E−03
23600

PH_hs_0027132
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
1.58
3.447E−05
1952

PH_hs_0013522
FYCO1
FYVE and coiled-coil domain containing 1
1.58
2.311E−06
79443

PH_hs_0045034
SP100
SP100 nuclear antigen
1.58
7.247E−03
6672

PH_hs_0035085
PPARA
peroxisome proliferator-activated receptor alpha
1.58
2.721E−05
5465

PH_hs_0031001
ACTR3B|LOC10029
ARP3 actin-related protein 3 homolog B (yeast)|actin-related protein 3B-like
1.58
9.928E−03
57180|10029021

0215

5

PH_hs_0031048
ZSCAN21
zinc finger and SCAN domain containing 21
1.58
1.902E−02
7589

PH_hs_0003114
MSC
musculin
1.58
1.337E−03
9242

PH_hs_0043581
AIMP1
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
1.58
4.000E−05
9255

PH_hs_0048354
C20orf11
chromosome 20 open reading frame 11
1.59
4.137E−05
54994

PH_hs_0048878
RAD1
RAD1 homolog (S. pombe)
1.59
2.970E−06
5810

PH_hs_0016338
ORAI3
ORAI calcium release-activated calcium modulator 3
1.59
1.111E−03
93129

PH_hs_0014922
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
1.59
1.421E−03
59338

PH_hs_0023122
KIAA0182
KIAA0182
1.59
1.038E−03
23199

PH_hs_0048407
PLA2G12A
phospholipase A2, group XIIA
1.59
6.881E−05
81579

PH_hs_0023005
SNAP23
synaptosomal-associated protein, 23 kDa
1.59
1.444E−09
8773

PH_hs_0043617
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
1.59
1.171E−06
29796

PH_hs_0022779
ANKRD10
ankyrin repeat domain 10
1.59
4.515E−07
55608

PH_hs_0024429
FOXRED2
FAD-dependent oxidoreductase domain containing 2
1.59
6.057E−03
80020

PH_hs_0044173
MFAP3
microfibrillar-associated protein 3
1.59
1.286E−06
4238

PH_hs_0025588
ATP10D
ATPase, class V, type 10D
1.59
1.417E−03
57205

PH_hs_0011594
KIAA0240
KIAA0240
1.59
1.693E−03
23506

PH_hs_0001803
LHPP
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
1.59
9.655E−03
64077

PH_hs_0014304
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
1.59
6.835E−05
1979

PH_hs_0003753
C16orf91
chromosome 16 open reading frame 91
1.59
6.459E−04
283951

PH_hs_0022328
BRP44L
brain protein 44-like
1.59
4.158E−06
51660

PH_hs_0014106
DCAF13|LOC10013
DDB1 and CUL4 associated factor 13|DDB1 and CUL4 associated factor 13 pseudogene
1.59
5.874E−11
25879|100132724

2724

PH_hs_0015077
ESCO1
establishment of cohesion 1 homolog 1 (S. cerevisiae)
1.59
1.047E−05
114799

PH_hs_0014660
RNPEP
arginyl aminopeptidase (aminopeptidase B)
1.60
3.948E−03
6051

PH_hs_0046336
FAM154B
family with sequence similarity 154, member B
1.60
1.957E−03
283726

PH_hs_0045874
TFEB
transcription factor EB
1.60
1.545E−02
7942

PH_hs_0030122
CLNS1A
chloride channel, nucleotide-sensitive, 1A
1.60
6.918E−07
1207

PH_hs_0009587
MSI1
musashi homolog 1 (Drosophila)
1.60
2.309E−02
4440

PH_hs_0048517
RG9MTD3
RNA (guanine-9-) methyltransferase domain containing 3
1.60
9.403E−03
158234

PH_hs_0032912
MAU2
MAU2 chromatid cohesion factor homolog (C. elegans)
1.60
1.497E−02
23383

PH_hs_0049428
CRTAP
cartilage associated protein
1.60
1.593E−09
10491

PH_hs_0026756
RRM2B
ribonucleotide reductase M2 B (TP53 inducible)
1.60
2.110E−02
50484

PH_hs_0020075
LOC100506710
hypothetical LOC100506710
1.60
2.700E−02
100506710

PH_hs_0049738
WBP1
WW domain binding protein 1
1.60
3.799E−03
23559

PH_hs_0002279
LPIN3
lipin 3
1.60
3.974E−02
64900

PH_hs_0009258
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
1.60
8.097E−07
9139

PH_hs_0031558
MAN2A2
mannosidase, alpha, class 2A, member 2
1.60
7.157E−08
4122

PH_hs_0016092
YIPF2
Yip1 domain family, member 2
1.60
1.427E−07
78992

PH_hs_0002228
PRSS23
protease, serine, 23
1.60
9.689E−03
11098

PH_hs_0009253
PUM1
pumilio homolog 1 (Drosophila)
1.60
1.256E−06
9698

PH_hs_0045052
PHF14
PHD finger protein 14
1.60
1.267E−09
9678

PH_hs_0047595
ZSCAN29
zinc finger and SCAN domain containing 29
1.60
1.517E−04
146050

PH_hs_0048120
XAF1
XIAP associated factor 1
1.60
5.328E−05
54739

PH_hs_0012489
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
1.60
1.549E−02
80853

PH_hs_0027917
FAM173A
family with sequence similarity 173, member A
1.60
2.586E−02
65990

PH_hs_0048982
MTSS1L
metastasis suppressor 1-like
1.60
8.727E−03
92154

PH_hs_0049657
DEAF1|LOC100294
deformed epidermal autoregulatory factor 1 (Drosophila)|deformed epidermal autoregulatory factor 1 homolog|deformed
1.60
2.179E−02
10522|10029441

411|LOC100510366
epidermal autoregulatory factor 1 homolog

1|100510366

PH_hs_0044463
LEPRE1
leucine proline-enriched proteoglycan (leprecan) 1
1.60
6.830E−04
64175

PH_hs_0019278
ATP9A
ATPase, class II, type 9A
1.60
6.232E−05
10079

PH_hs_0011495
EZH1
enhancer of zeste homolog 1 (Drosophila)
1.60
1.167E−02
2145

PH_hs_0001383
IFI30
interferon, gamma-inducible protein 30
1.60
1.553E−07
10437

PH_hs_0033907
C3orf37
chromosome 3 open reading frame 37
1.60
1.830E−06
56941

PH_hs_0045429
CARD14
caspase recruitment domain family, member 14
1.61
6.212E−03
79092

PH_hs_0004131
NLGN1
neuroligin 1
1.61
4.238E−06
22871

PH_hs_0043769
YME1L1
YME1-like 1 (S. cerevisiae)
1.61
4.313E−06
10730

PH_hs_0047505
REV1
REV1 homolog (S. cerevisiae)
1.61
3.372E−03
51455

PH_hs_0033483
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
1.61
2.386E−06
51111

PH_hs_0009246
SGMS1
sphingomyelin synthase 1
1.61
1.451E−05
259230

PH_hs_0023732
ORC3
origin recognition complex, subunit 3
1.61
5.159E−10
23595

PH_hs_0044172
TBX6
T-box 6
1.61
4.391E−05
6911

PH_hs_0009272
JDP2
Jun dimerization protein 2
1.61
1.257E−05
122953

PH_hs_0047502
LYST
lysosomal trafficking regulator
1.61
3.861E−05
1130

PH_hs_0001689
UBE2D4
ubiquitin-conjugating enzyme E2D 4 (putative)
1.61
2.288E−07
51619

PH_hs_0005789
ZNF195
zinc finger protein 195
1.62
1.791E−04
7748

PH_hs_0001062
LIMA1
LIM domain and actin binding 1
1.62
1.284E−02
51474

PH_hs_0037014
LOC283788
FSHD region gene 1 pseudogene
1.62
1.236E−03
283788

PH_hs_0045072
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
1.62
9.633E−05
1788

PH_hs_0024031
MEIS2
Meis homeobox 2
1.62
1.225E−08
4212

PH_hs_0048988
PTPRJ
protein tyrosine phosphatase, receptor type, J
1.62
1.211E−03
5795

PH_hs_0025758
SLC37A3
solute carrier family 37 (glycerol-3-phosphate transporter), member 3
1.62
3.277E−04
84255

PH_hs_0049273
CERKL
ceramide kinase-like
1.62
2.574E−02
375298

PH_hs_0004334
ANXA11
annexin A11
1.62
1.755E−05
311

PH_hs_0048118
ADRA1B
adrenergic, alpha-1B-, receptor
1.62
1.722E−02
147

PH_hs_0022987
WDR3
WD repeat domain 3
1.62
2.639E−06
10885

PH_hs_0033950
NTN1
netrin 1
1.62
1.653E−04
9423

PH_hs_0000457
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
1.62
8.098E−08
90410

PH_hs_0025978
KIAA0895L
KIAA0895-like
1.62
2.220E−06
653319

PH_hs_0015931
KILLIN
killin protein
1.62
1.676E−02
100144748

PH_hs_0030138
NCOA4
nuclear receptor coactivator 4
1.62
3.169E−02
8031

PH_hs_0044163
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
1.63
5.787E−05
3338

PH_hs_0029640
DGAT1
diacylglycerol O-acyltransferase 1
1.63
9.096E−03
8694

PH_hs_0014146
CPT2
carnitine palmitoyltransferase 2
1.63
3.949E−06
1376

PH_hs_0033101
DDIT3
DNA-damage-inducible transcript 3
1.63
4.381E−07
1649

PH_hs_0004516
MYCBP|GJA9-
c-myc binding protein|GJA9-MYCBP read-through transcript
1.63
6.147E−06
26292|10052795

MYCBP

0

PH_hs_0047608
CCNG1
cyclin G1
1.63
2.089E−09
900

PH_hs_0043207
IDI1
isopentenyl-diphosphate delta isomerase 1
1.63
4.124E−03
3422

PH_hs_0044933
RAB4A
RAB4A, member RAS oncogene family
1.63
2.044E−04
5867

PH_hs_0049089
ANKIB1
ankyrin repeat and IBR domain containing 1
1.63
3.147E−05
54467

PH_hs_0031757
ZNF358
zinc finger protein 358
1.63
5.418E−06
140467

PH_hs_0047479
PAFAH2
platelet-activating factor acetylhydrolase 2, 40 kDa
1.63
1.509E−04
5051

PH_hs_0004550
BTD
biotinidase
1.63
1.471E−07
686

PH_hs_0028609
ZNF883
zinc finger protein 883
1.63
5.789E−04
169834

PH_hs_0043810
TUT1
terminal uridylyl transferase 1, U6 snRNA-specific
1.63
1.455E−06
64852

PH_hs_0035910
C2orf79
chromosome 2 open reading frame 79
1.63
1.321E−05
391356

PH_hs_0000943
PCOLCE2
procollagen C-endopeptidase enhancer 2
1.63
9.240E−04
26577

PH_hs_0019224
CCDC137
coiled-coil domain containing 137
1.63
7.104E−03
339230

PH_hs_0045600
ZDHHC15
zinc finger, DHHC-type containing 15
1.64
1.855E−02
158866

PH_hs_0044912
HOXA4
homeobox A4
1.64
1.112E−07
3201

PH_hs_0002170
KIAA0907
KIAA0907
1.64
6.458E−10
22889

PH_hs_0046354
FAM149B1
family with sequence similarity 149, member B1
1.64
8.722E−03
317662

PH_hs_0000723
PIGG
phosphatidylinositol glycan anchor biosynthesis, class G
1.64
1.007E−07
54872

PH_hs_0005689
MADCAM1
mucosal vascular addressin cell adhesion molecule 1
1.64
4.911E−04
8174

PH_hs_0013010
SLC2A6
solute carrier family 2 (facilitated glucose transporter), member 6
1.64
3.664E−03
11182

PH_hs_0029552
IMMT
inner membrane protein, mitochondrial
1.64
4.872E−05
10989

PH_hs_0045062
OAS2
2′-5′-oligoadenylate synthetase 2, 69/71 kDa
1.64
1.995E−02
4939

PH_hs_0023084
ITGA6
integrin, alpha 6
1.64
2.871E−02
3655

PH_hs_0026675
NT5DC1
5′-nucleotidase domain containing 1
1.64
3.635E−06
221294

PH_hs_0029676
BID
BH3 interacting domain death agonist
1.64
2.786E−05
637

PH_hs_0033245
KLHDC2
kelch domain containing 2
1.64
6.251E−05
23588

PH_hs_0044326
ZDHHC4
zinc finger, DHHC-type containing 4
1.64
2.436E−07
55146

PH_hs_0002393
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
1.64
1.148E−03
1102

PH_hs_0002304
TRPS1
trichorhinophalangeal syndrome I
1.64
8.441E−03
7227

PH_hs_0004528
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
1.64
1.536E−08
4882

PH_hs_0049353
SGPL1
sphingosine-1-phosphate lyase 1
1.64
2.770E−06
8879

PH_hs_0031026
C9orf23
chromosome 9 open reading frame 23
1.64
1.784E−04
138716

PH_hs_0004553
AKAP1
A kinase (PRKA) anchor protein 1
1.64
1.502E−05
8165

PH_hs_0028801
WDR45
WD repeat domain 45
1.64
3.369E−03
11152

PH_hs_0018576
GABARAP
GABA(A) receptor-associated protein
1.64
1.937E−08
11337

PH_hs_0044278
RAD51C
RAD51 homolog C (S. cerevisiae)
1.65
2.771E−05
5889

PH_hs_0003532
TUG1
taurine upregulated 1 (non-protein coding)
1.65
7.814E−06
55000

PH_hs_0024179
ZNF227
zinc finger protein 227
1.65
6.551E−04
7770

PH_hs_0010786
LOC100506469
hypothetical LOC100506469
1.65
1.617E−04
100506469

PH_hs_0032689
ACAD10
acyl-CoA dehydrogenase family, member 10
1.65
7.588E−04
80724

PH_hs_0029827
COX6C
cytochrome c oxidase subunit Vic
1.65
3.069E−09
1345

PH_hs_0003364
WDR91
WD repeat domain 91
1.65
3.741E−04
29062

PH_hs_0012404
PAPD4
PAP associated domain containing 4
1.65
2.586E−03
167153

PH_hs_0016855
C1orf131
chromosome 1 open reading frame 131
1.65
4.999E−09
128061

PH_hs_0022679
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
1.65
2.181E−05
11176

PH_hs_0023824
CASP9
caspase 9, apoptosis-related cysteine peptidase
1.65
3.389E−07
842

PH_hs_0045990
MKRN1
makorin ring finger protein 1
1.65
1.028E−07
23608

PH_hs_0033427
TPST2
tyrosylprotein sulfotransferase 2
1.65
1.672E−05
8459

PH_hs_0048332
ZFP41
zinc finger protein 41 homolog (mouse)
1.65
1.482E−02
286128

PH_hs_0005443
CCDC88B
coiled-coil domain containing 88B
1.65
9.200E−05
283234

PH_hs_0045165
KLF8
Kruppel-like factor 8
1.65
8.970E−03
11279

PH_hs_0004785
APPBP2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
1.65
7.063E−09
10513

PH_hs_0025597
NECAP2
NECAP endocytosis associated 2
1.65
3.159E−05
55707

PH_hs_0047382
PTEN
phosphatase and tensin homolog
1.65
4.096E−06
5728

PH_hs_0016640
EXOSC4
exosome component 4
1.65
4.486E−09
54512

PH_hs_0004539
ZNF32
zinc finger protein 32
1.65
1.262E−03
7580

PH_hs_0043379
TUBA1A
tubulin, alpha 1a
1.66
9.471E−10
7846

PH_hs_0027148
SSR2
signal sequence receptor, beta (translocon-associated protein beta)
1.66
6.356E−06
6746

PH_hs_0003841
C19orf54
chromosome 19 open reading frame 54
1.66
2.926E−08
284325

PH_hs_0004295
BRD2
bromodomain containing 2
1.66
6.666E−07
6046

PH_hs_0049162
SIK3
SIK family kinase 3
1.66
7.008E−03
23387

PH_hs_0044636
SLC30A5
solute carrier family 30 (zinc transporter), member 5
1.66
2.242E−03
64924

PH_hs_0001241
ZHX1
zinc fingers and homeoboxes 1
1.66
2.571E−07
11244

PH_hs_0001589
FLJ40852
hypothetical LOC285962
1.66
1.463E−02
285962

PH_hs_0017041
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
1.66
2.256E−04
170572

PH_hs_0042819
HRCT1
histidine rich carboxyl terminus 1
1.66
4.303E−03
646962

PH_hs_0043608
FUT2
fucosyltransferase 2 (secretor status included)
1.66
4.174E−03
2524

PH_hs_0044026
LOC100129999
hypothetical LOC100129999
1.66
3.297E−03
100129999

PH_hs_0004373
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
1.66
3.785E−06
5106

PH_hs_0002243
TGFB1I1
transforming growth factor beta 1 induced transcript 1
1.66
6.547E−03
7041

PH_hs_0000401
CASP6
caspase 6, apoptosis-related cysteine peptidase
1.66
6.378E−09
839

PH_hs_0011914
RING1
ring finger protein 1
1.66
4.582E−08
6015

PH_hs_0026387
TIGD7
tigger transposable element derived 7
1.66
3.100E−02
91151

PH_hs_0006967
HAGHL
hydroxyacylglutathione hydrolase-like
1.66
1.243E−06
84264

PH_hs_0004292
SEC14L1
SEC14-like 1 (S. cerevisiae)
1.66
4.703E−05
6397

PH_hs_0022822
RNF14
ring finger protein 14
1.66
7.217E−06
9604

PH_hs_0043191
ESRRA
estrogen-related receptor alpha
1.66
1.592E−05
2101

PH_hs_0045284
LOC100287188
protein FAM104B-like
1.66
3.688E−06
100287188

PH_hs_0004376
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
1.66
1.706E−10
10962

PH_hs_0026941
FBXO46
F-box protein 46
1.66
1.841E−02
23403

PH_hs_0047422
AHR
aryl hydrocarbon receptor
1.67
5.562E−10
196

PH_hs_0020904
MAN2A1
mannosidase, alpha, class 2A, member 1
1.67
7.157E−08
4124

PH_hs_0043712
ENO3
enolase 3 (beta, muscle)
1.67
8.931E−04
2027

PH_hs_0012892
ANKRA2
ankyrin repeat, family A (RFXANK-like), 2
1.67
1.064E−06
57763

PH_hs_0047216
C21orf91
chromosome 21 open reading frame 91
1.67
4.654E−04
54149

PH_hs_0004414
SLC38A3
solute carrier family 38, member 3
1.67
1.446E−02
10991

PH_hs_0001741
SYF2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
1.67
1.989E−07
25949

PH_hs_0043728
ZNF706
zinc finger protein 706
1.67
5.606E−05
51123

PH_hs_0042863
ZXDB
zinc finger, X-linked, duplicated B
1.67
1.290E−06
158586

PH_hs_0018969
PAIP2
poly(A) binding protein interacting protein 2
1.68
4.624E−09
51247

PH_hs_0048231
TMEM8B
transmembrane protein 8B
1.68
2.743E−05
51754

PH_hs_0029146
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
1.68
2.037E−03
610

PH_hs_0026554
FADS1
fatty acid desaturase 1
1.68
3.140E−05
3992

PH_hs_0004683
GYPC
glycophorin C (Gerbich blood group)
1.68
2.865E−07
2995

PH_hs_0008452
ZBTB33
zinc finger and BTB domain containing 33
1.68
6.550E−10
10009

PH_hs_0013065
SNRNP200
small nuclear ribonucleoprotein 200 kDa (U5)
1.68
5.073E−09
23020

PH_hs_0043268
COQ9
coenzyme Q9 homolog (S. cerevisiae)
1.68
4.103E−05
57017

PH_hs_0002081
MST4
serine/threonine protein kinase MST4
1.68
2.108E−13
51765

PH_hs_0010871
SLC7A5
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
1.68
3.951E−06
8140

PH_hs_0028376
INSIG1
insulin induced gene 1
1.68
2.145E−05
3638

PH_hs_0025814
DDR2
discoidin domain receptor tyrosine kinase 2
1.68
1.638E−05
4921

PH_hs_0048961
VPS36
vacuolar protein sorting 36 homolog (S. cerevisiae)
1.68
2.591E−04
51028

PH_hs_0023950
FCGR2A
Fc fragment of IgG, low affinity Ma, receptor (CD32)
1.68
1.289E−03
2212

PH_hs_0017080
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
1.68
4.681E−09
10602

PH_hs_0047312
FAM200B
family with sequence similarity 200, member B
1.68
2.126E−03
285550

PH_hs_0023658
RUFY1
RUN and FYVE domain containing 1
1.68
1.233E−06
80230

PH_hs_0042175
ZNF7
zinc finger protein 7
1.69
4.552E−04
7553

PH_hs_0048105
FAM117B
family with sequence similarity 117, member B
1.69
1.004E−07
150864

PH_hs_0027115
C6orf203
chromosome 6 open reading frame 203
1.69
6.111E−03
51250

PH_hs_0049463
UBTD2
ubiquitin domain containing 2
1.69
5.780E−04
92181

PH_hs_0043760
GPS2
G protein pathway suppressor 2
1.69
2.336E−07
2874

PH_hs_0023932
ATP5SL
ATP5S-like
1.69
3.430E−09
55101

PH_hs_0002159
EFS
embryonal Fyn-associated substrate
1.69
1.152E−02
10278

PH_hs_0005189
MCEE
methylmalonyl CoA epimerase
1.69
1.962E−05
84693

PH_hs_0022191
MKNK1
MAP kinase interacting serine/threonine kinase 1
1.69
5.955E−08
8569

PH_hs_0033268
VHL
von Hippel-Lindau tumor suppressor
1.69
1.565E−06
7428

PH_hs_0048569
SORBS2
sorbin and SH3 domain containing 2
1.69
2.761E−06
8470

PH_hs_0004274
TRIM9
tripartite motif-containing 9
1.69
2.128E−05
114088

PH_hs_0044328
CAPS2
calcyphosine 2
1.69
1.140E−04
84698

PH_hs_0015555
KIAA0513
KIAA0513
1.69
7.975E−03
9764

PH_hs_0014078
DHRS2
dehydrogenase/reductase (SDR family) member 2
1.69
9.406E−03
10202

PH_hs_0005896
JRKL
jerky homolog-like (mouse)
1.69
7.156E−03
8690

PH_hs_0022115
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59 kDa, basic component 2)
1.70
6.213E−05
6645

PH_hs_0005461
PUS3
pseudouridylate synthase 3
1.70
1.796E−02
83480

PH_hs_0042603
OR10AG1
olfactory receptor, family 10, subfamily AG, member 1
1.70
3.130E−02
282770

PH_hs_0044545
ATP2A2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
1.70
4.425E−03
488

PH_hs_0030085
GTF2I|GTF2IP1|LO
general transcription factor II general transcription factor III, pseudogene 1|general transcription factor II, I, pseudogene
1.70
1.888E−03
2969|2970|1000

C100093631

93631

PH_hs_0016043
ABHD8
abhydrolase domain containing 8
1.70
4.693E−06
79575

PH_hs_0032403
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
1.70
6.697E−05
10813

PH_hs_0048328
GOLM1
golgi membrane protein 1
1.70
2.841E−16
51280

PH_hs_0047201
JAK3
Janus kinase 3
1.70
3.679E−04
3718

PH_hs_0044054
MGC4294
hypothetical MGC4294
1.70
1.113E−05
79160

PH_hs_0044881
AASS
aminoadipate-semialdehyde synthase
1.70
1.813E−08
10157

PH_hs_0000201
SDC2
syndecan 2
1.70
8.975E−08
6383

PH_hs_0022040
EPC2
enhancer of polycomb homolog 2 (Drosophila)
1.70
3.370E−04
26122

PH_hs_0042218
CPSF1
cleavage and polyadenylation specific factor 1, 160 kDa
1.70
7.951E−07
29894

PH_hs_0026618
LILRA6
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
1.70
1.974E−04
79168

PH_hs_0042180
FAM195A
family with sequence similarity 195, member A
1.71
1.447E−04
84331

PH_hs_0023317
GSTT1
glutathione S-transferase theta 1
1.71
5.419E−03
2952

PH_hs_0048580
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
1.71
2.217E−04
6546

PH_hs_0047777
LOC283070
hypothetical LOC283070
1.71
8.572E−04
283070

PH_hs_0049052
NEK9
NIMA (never in mitosis gene a)- related kinase 9
1.71
6.992E−08
91754

PH_hs_0000635
DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
1.71
3.821E−07
26007

PH_hs_0010665
LONRF1
LON peptidase N-terminal domain and ring finger 1
1.71
4.253E−03
91694

PH_hs_0017204
CYB561
cytochrome b-561
1.71
4.352E−04
1534

PH_hs_0005010
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
1.71
4.868E−04
2052

PH_hs_0004348
DHCR24
24-dehydrocholesterol reductase
1.71
4.708E−06
1718

PH_hs_0048984
ARHGAP26
Rho GTPase activating protein 26
1.71
2.205E−04
23092

PH_hs_0049038
CYP2U1
cytochrome P450, family 2, subfamily U, polypeptide 1
1.71
3.685E−03
113612

PH_hs_0006005
HAAO
3-hydroxyanthranilate 3,4-dioxygenase
1.71
4.998E−04
23498

PH_hs_0048317
SSH1
slingshot homolog 1 (Drosophila)
1.71
4.971E−04
54434

PH_hs_0028961
GJA1
gap junction protein, alpha 1, 43 kDa
1.71
6.654E−10
2697

PH_hs_0037684
SPRR2C|SPRR2F|
small proline-rich protein 2C (pseudogene)|small proline-rich protein 2F|small proline-rich protein 2A|small proline-rich
1.71
8.339E−03
6702|6705|6700|

SPRR2A|SPRR2D|
protein 2D|small proline-rich protein 2B

6703|6701

SPRR2B

PH_hs_0022089
RHOBTB3
Rho-related BTB domain containing 3
1.72
2.189E−11
22836

PH_hs_0044498
PDLIM5
PDZ and LIM domain 5
1.72
1.826E−04
10611

PH_hs_0049222
CDK6
cyclin-dependent kinase 6
1.72
1.062E−03
1021

PH_hs_0005169
FZD1
frizzled homolog 1 (Drosophila)
1.72
3.611E−07
8321

PH_hs_0015651
SDF2L1
stromal cell-derived factor 2-like 1
1.72
9.778E−12
23753

PH_hs_0027861
CCNL2
cyclin L2
1.72
8.564E−07
81669

PH_hs_0002696
PRDX5
peroxiredoxin 5
1.72
9.925E−08
25824

PH_hs_0048461
ANKH
ankylosis, progressive homolog (mouse)
1.73
6.258E−04
56172

PH_hs_0008852
ZNF331
zinc finger protein 331
1.73
4.777E−04
55422

PH_hs_0000005
PTN
pleiotrophin
1.73
2.386E−03
5764

PH_hs_0001196
NAP1L5
nucleosome assembly protein 1-like 5
1.73
3.798E−06
266812

PH_hs_0042738
TTC32
tetratricopeptide repeat domain 32
1.73
3.957E−04
130502

PH_hs_0027325
TPM4
tropomyosin 4
1.73
2.504E−05
7171

PH_hs_0031502
PARM1
prostate androgen-regulated mucin-like protein 1
1.74
9.257E−04
25849

PH_hs_0002223
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
1.74
5.100E−09
64411

PH_hs_0004678
AUH
AU RNA binding protein/enoyl-CoA hydratase
1.74
9.569E−07
549

PH_hs_0009955
TBX15
T-box 15
1.74
6.616E−09
6913

PH_hs_0047896
USP2
ubiquitin specific peptidase 2
1.74
2.468E−02
9099

PH_hs_0010764
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
1.74
7.337E−06
4809

PH_hs_0024042
SELO
selenoprotein O
1.74
1.844E−08
83642

PH_hs_0048599
STX17
syntaxin 17
1.74
4.209E−07
55014

PH_hs_0047314
RINL
Ras and Rab interactor-like
1.74
2.707E−03
126432

PH_hs_0016467
ACY1|ABHD14A-
aminoacylase 1|ABHD14A-ACY1 read-through transcript
1.74
2.152E−04
95|100526760

ACY1

PH_hs_0002734
ZNF395
zinc finger protein 395
1.74
5.218E−11
55893

PH_hs_0048639
ARHGAP23
Rho GTPase activating protein 23
1.74
5.289E−07
57636

PH_hs_0018415
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
1.74
2.317E−05
7029

PH_hs_0026721
MKNK2
MAP kinase interacting serine/threonine kinase 2
1.75
1.161E−06
2872

PH_hs_0002278
SYTL1
synaptotagmin-like 1
1.75
2.669E−04
84958

PH_hs_0035906
MRPS21
mitochondrial ribosomal protein S21
1.75
3.374E−05
54460

PH_hs_0032572
TRIM45
tripartite motif-containing 45
1.75
4.049E−07
80263

PH_hs_0033001
TMEM173
transmembrane protein 173
1.75
1.796E−10
340061

PH_hs_0002554
COLEC12
collectin sub-family member 12
1.75
3.852E−03
81035

PH_hs_0030672
HSP90B3P|HSP90
heat shock protein 90 kDa beta (Grp94), member 3 (pseudogene)|heat shock protein 90 kDa beta (Grp94), member 1
1.75
3.486E−04
343477|7184

B1

PH_hs_0043173
AHSA2
AHA1, activator of heat shock 90 kDa protein ATPase homolog 2 (yeast)
1.76
1.216E−04
130872

PH_hs_0043127
RPL37
ribosomal protein L37
1.76
1.916E−02
6167

PH_hs_0047769
FBXW7
F-box and WD repeat domain containing 7
1.76
1.167E−04
55294

PH_hs_0027424
SPRY3
sprouty homolog 3 (Drosophila)
1.76
1.958E−02
10251

PH_hs_0048217
SETX
senataxin
1.76
3.813E−07
23064

PH_hs_0032014
SSX3|SSX2B|SSX2
synovial sarcoma, X breakpoint 3|synovial sarcoma, X breakpoint 2B|synovial sarcoma, X breakpoint 2|synovial sarcoma,
1.76
7.266E−09
10214|727837|6

|SSX1|SSX6|SSX8|
breakpoint 1|synovial sarcoma, X breakpoint 6 (pseudogene)|synovial sarcoma, X breakpoint 8|synovial sarcoma, X

757|6756|28065

SSX4B|SSX5|SSX4
breakpoint 4B|synovial sarcoma, X breakpoint 5|synovial sarcoma, X breakpoint 4

7|280659|54831

3|6758|6759

PH_hs_0004403
REEP6
receptor accessory protein 6
1.77
3.483E−08
92840

PH_hs_0023957
TBC1D24
TBC1 domain family, member 24
1.77
3.544E−08
57465

PH_hs_0003835
DAPL1
death associated protein-like 1
1.77
1.584E−09
92196

PH_hs_0014780
C14orf159
chromosome 14 open reading frame 159
1.77
9.423E−06
80017

PH_hs_0001843
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
1.77
1.737E−02
56916

PH_hs_0023854
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
1.77
3.258E−06
1000

PH_hs_0049386
TBC1D4
TBC1 domain family, member 4
1.77
2.277E−05
9882

PH_hs_0004699
ELF2
E74-like factor 2 (ets domain transcription factor)
1.77
9.693E−06
1998

PH_hs_0030842
LEPREL4
leprecan-like 4
1.77
3.572E−11
10609

PH_hs_0020913
NBL1
neuroblastoma, suppression of tumorigenicity 1
1.77
8.672E−13
4681

PH_hs_0006583
APCDD1L
adenomatosis polyposis coli down-regulated 1-like
1.77
5.450E−08
164284

PH_hs_0021012
YIPF3
Yip1 domain family, member 3
1.77
1.860E−06
25844

PH_hs_0003910
LOC400657
hypothetical LOC400657
1.77
1.397E−03
400657

PH_hs_0000273
SLC25A4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
1.78
2.834E−13
291

PH_hs_0043494
HDAC10
histone deacetylase 10
1.78
2.214E−08
83933

PH_hs_0049183
GDPD1
glycerophosphodiester phosphodiesterase domain containing 1
1.78
3.658E−04
284161

PH_hs_0024178
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
1.78
2.096E−11
6929

PH_hs_0036875
LOC25845
hypothetical LOC25845
1.78
5.602E−07
25845

PH_hs_0003199
PARVA
parvin, alpha
1.78
1.868E−06
55742

PH_hs_0009907
NDUFA2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8 kDa
1.78
3.057E−11
4695

PH_hs_0010303
ADAM10
ADAM metallopeptidase domain 10
1.78
3.479E−05
102

PH_hs_0032660
IP6K2
inositol hexakisphosphate kinase 2
1.78
1.123E−06
51447

PH_hs_0016846
ODZ1
odz, odd Oz/ten-m homolog 1(Drosophila)
1.78
1.634E−05
10178

PH_hs_0025907
FECH
ferrochelatase
1.79
6.082E−08
2235

PH_hs_0044270
FAM135A
family with sequence similarity 135, member A
1.79
1.628E−06
57579

PH_hs_0044958
UCKL1-AS1
UCKL1 antisense RNA 1 (non-protein coding)
1.79
1.856E−03
100113386

PH_hs_0015564
STK11
serine/threonine kinase 11
1.79
9.915E−09
6794

PH_hs_0029967
C20orf30
chromosome 20 open reading frame 30
1.79
1.179E−10
29058

PH_hs_0017531
PDCD2
programmed cell death 2
1.79
5.583E−08
5134

PH_hs_0002291
PRMT6
protein arginine methyltransferase 6
1.79
1.007E−10
55170

PH_hs_0030709
TDG
thymine-DNA glycosylase
1.79
1.029E−09
6996

PH_hs_0004669
ZCCHC14
zinc finger, CCHC domain containing 14
1.79
1.622E−05
23174

PH_hs_0000425
ASXL1
additional sex combs like 1 (Drosophila)
1.79
1.899E−08
171023

PH_hs_0037100
MAPKSP1
MAPK scaffold protein 1
1.79
2.270E−04
8649

PH_hs_0006026
DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
1.79
2.652E−08
8818

PH_hs_0010270
USP11
ubiquitin specific peptidase 11
1.79
1.344E−04
8237

PH_hs_0042311
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
1.80
3.659E−10
9744

PH_hs_0049092
AGGF1
angiogenic factor with G patch and FHA domains 1
1.80
3.362E−08
55109

PH_hs_0009177
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
1.80
1.486E−03
4524

PH_hs_0028356
C9orf16
chromosome 9 open reading frame 16
1.80
5.328E−07
79095

PH_hs_0049348
UNG
uracil-DNA glycosylase
1.80
7.338E−12
7374

PH_hs_0024775
MRPS36
mitochondrial ribosomal protein S36
1.80
1.174E−05
92259

PH_hs_0025554
KIAA0355
KIAA0355
1.80
1.469E−06
9710

PH_hs_0032654
SYVN1
synovial apoptosis inhibitor 1, synoviolin
1.81
2.419E−04
84447

PH_hs_0047771
PSME4
proteasome (prosome, macropain) activator subunit 4
1.81
3.705E−08
23198

PH_hs_0045596
NTM
neurotrimin
1.81
2.755E−03
50863

PH_hs_0004676
MGST2
microsomal glutathione S-transferase 2
1.81
2.881E−17
4258

PH_hs_0004332
TP53INP1
tumor protein p53 inducible nuclear protein 1
1.81
3.598E−12
94241

PH_hs_0024698
FKBP1B
FK506 binding protein 1B, 12.6 kDa
1.81
9.010E−05
2281

PH_hs_0024427
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
1.81
8.794E−04
5783

PH_hs_0015577
LMO3
LIM domain only 3 (rhombotin-like 2)
1.81
1.340E−02
55885

PH_hs_0004637
STAT4
signal transducer and activator of transcription 4
1.82
5.915E−03
6775

PH_hs_0003386
RCHY1
ring finger and CHY zinc finger domain containing 1
1.82
2.475E−03
25898

PH_hs_0048542
SNX1
sorting nexin 1
1.82
2.439E−13
6642

PH_hs_0002269
ATP6V0A2
ATPase, H+ transporting, lysosomal V0 subunit a2
1.82
5.328E−06
23545

PH_hs_0049460
DCAF16
DDB1 and CUL4 associated factor 16
1.82
2.320E−15
54876

PH_hs_0023908
SLC35C2
solute carrier family 35, member C2
1.82
1.119E−11
51006

PH_hs_0006395
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
1.82
1.963E−06
57016

PH_hs_0006538
MXI1
MAX interactor 1
1.82
2.678E−11
4601

PH_hs_0047616
RHOBTB1
Rho-related BTB domain containing 1
1.82
4.322E−04
9886

PH_hs_0043877
COMMD5
COMM domain containing 5
1.82
6.384E−04
28991

PH_hs_0023544
NCOA7
nuclear receptor coactivator 7
1.82
3.973E−12
135112

PH_hs_0011642
PGCP
plasma glutamate carboxypeptidase
1.82
2.757E−07
10404

PH_hs_0045568
NSUN5|NSUN5P1
NOP2/Sun domain family, member 5|NOP2/Sun domain family, member 5 pseudogene 1
1.83
1.676E−02
55695|155400

PH_hs_0047570
THNSL1
threonine synthase-like 1 (S. cerevisiae)
1.83
3.818E−03
79896

PH_hs_0031414
EIF4B
eukaryotic translation initiation factor 4B
1.83
1.642E−10
1975

PH_hs_0003988
PROS1
protein S (alpha)
1.83
6.746E−08
5627

PH_hs_0048500
WDR52
WD repeat domain 52
1.83
6.038E−11
55779

PH_hs_0047575
LRRC15
leucine rich repeat containing 15
1.84
4.693E−09
131578

PH_hs_0043182
INPP5J
inositol polyphosphate-5-phosphatase J
1.84
2.135E−03
27124

PH_hs_0047843
SIKE1
suppressor of IKBKE 1
1.84
8.761E−03
80143

PH_hs_0046804
TXNRD3
thioredoxin reductase 3
1.84
3.504E−05
114112

PH_hs_0027161
RGL1
ral guanine nucleotide dissociation stimulator-like 1
1.84
3.076E−07
23179

PH_hs_0048693
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
1.84
5.401E−05
55915

PH_hs_0037413
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
1.84
1.155E−04
6319

PH_hs_0025293
MYL9
myosin, light chain 9, regulatory
1.84
1.836E−02
10398

PH_hs_0048520
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
1.85
7.931E−05
4548

PH_hs_0048400
C14orf37
chromosome 14 open reading frame 37
1.85
1.658E−03
145407

PH_hs_0024444
RXRB
retinoid X receptor, beta
1.85
1.285E−02
6257

PH_hs_0045401
C9orf47
chromosome 9 open reading frame 47
1.85
4.062E−06
286223

PH_hs_0022284
ZFHX3
zinc finger homeobox 3
1.85
2.090E−04
463

PH_hs_0033290
ANAPC16
anaphase promoting complex subunit 16
1.85
4.920E−06
119504

PH_hs_0031856
MLYCD
malonyl-CoA decarboxylase
1.85
6.542E−09
23417

PH_hs_0043794
RPL32
ribosomal protein L32
1.86
7.861E−10
6161

PH_hs_0047272
UTP23
UTP23, small subunit (SSU) processome component, homolog (yeast)
1.86
4.335E−05
84294

PH_hs_0043952
HOXC4
homeobox C4
1.86
6.202E−05
3221

PH_hs_0019723
HOXD11
homeobox D11
1.86
4.758E−06
3237

PH_hs_0043477
FHL1
four and a half LIM domains 1
1.86
6.556E−11
2273

PH_hs_0000067
FUCA1
fucosidase, alpha-L-1, tissue
1.86
1.128E−08
2517

PH_hs_0002731
INPP1
inositol polyphosphate-1 -phosphatase
1.86
2.943E−09
3628

PH_hs_0019227
CREB3L1
cAMP responsive element binding protein 3-like 1
1.86
3.369E−11
90993

PH_hs_0048324
ZBTB42
zinc finger and BTB domain containing 42
1.86
8.390E−03
100128927

PH_hs_0001569
TTC17
tetratricopeptide repeat domain 17
1.86
2.515E−07
55761

PH_hs_0047553
C14orf147
chromosome 14 open reading frame 147
1.86
8.254E−04
171546

PH_hs_0049187
LYRM7
Lyrm7 homolog (mouse)
1.87
8.952E−09
90624

PH_hs_0020051
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
1.87
4.566E−10
9649

PH_hs_0047566
ZNF252
zinc finger protein 252
1.87
1.657E−08
286101

PH_hs_0000336
AVPR2
arginine vasopressin receptor 2
1.87
1.010E−03
554

PH_hs_0005562
TRIM66
tripartite motif-containing 66
1.87
4.678E−08
9866

PH_hs_0006529
MRGPRF
MAS-related GPR, member F
1.87
1.895E−05
116535

PH_hs_0004529
PRUNE
prune homolog (Drosophila)
1.87
7.967E−08
58497

PH_hs_0022051
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
1.87
2.720E−07
7586

PH_hs_0046005
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B (yeast)
1.87
8.474E−12
26521

PH_hs_0032414
SGSM2
small G protein signaling modulator 2
1.87
7.506E−05
9905

PH_hs_0001748
RXRA
retinoid X receptor, alpha
1.87
1.042E−04
6256

PH_hs_0009027
RPS6KA1
ribosomal protein S6 kinase, 90 kDa, polypeptide 1
1.87
2.210E−02
6195

PH_hs_0011507
DIRAS3
DIRAS family, GTP-binding RAS-like 3
1.87
8.847E−06
9077

PH_hs_0001519
PODXL
podocalyxin-like
1.87
3.383E−12
5420

PH_hs_0008047
C6orf226
chromosome 6 open reading frame 226
1.87
6.461E−04
441150

PH_hs_0049316
COL5A1
collagen, type V, alpha 1
1.87
1.013E−07
1289

PH_hs_0042093
C11orf10
chromosome 11 open reading frame 10
1.87
7.744E−06
746.

PH_hs_0045836
SIPA1
signal-induced proliferation-associated 1
1.88
6.350E−08
6494

PH_hs_0009068
KLF9
Kruppel-like factor 9
1.88
2.083E−03
687

PH_hs_0022757
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
1.88
2.366E−06
6599

PH_hs_0035301
SPIN2B|SPIN2A
spindlin family, member 2B|spindlin family, member 2A
1.88
1.382E−04
474343|54466

PH_hs_0048289
UBTF
upstream binding transcription factor, RNA polymerase I
1.88
1.653E−09
7343

PH_hs_0005203
FAM8A1
family with sequence similarity 8, member A1
1.88
9.793E−05
51439

PH_hs_0046157
TNS3
tensin 3
1.88
5.242E−07
64759

PH_hs_0002295
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
1.88
2.276E−08
5686

PH_hs_0006488
MTHFS|ST20-
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)|ST20-MTHFS read-through transcript
1.88
5.184E−09
10588|10052802

MTHFS

1

PH_hs_0001105
CTSF
cathepsin F
1.88
2.149E−10
8722

PH_hs_0043405
C2orf64
chromosome 2 open reading frame 64
1.88
9.922E−08
493753

PH_hs_0049170
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
1.89
1.853E−05
4302

PH_hs_0047825
FAM43A
family with sequence similarity 43, member A
1.89
8.101E−04
131583

PH_hs_0028077
GALNT1
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
1.89
1.023E−04
2589

PH_hs_0006554
LOC152217
hypothetical LOC152217
1.89
1.972E−09
152217

PH_hs_0045139
CSTF3
cleavage stimulation factor, 3′ pre-RNA, subunit 3, 77 kDa
1.89
7.321E−04
1479

PH_hs_0047482
CNST
consortin, connexin sorting protein
1.89
1.097E−05
163882

PH_hs_0040048
MT1E
metallothionein 1E
1.89
1.056E−12
4493

PH_hs_0000840
CYTH3
cytohesin 3
1.89
1.366E−08
9265

PH_hs_0005209
RBM47
RNA binding motif protein 47
1.89
7.857E−06
54502

PH_hs_0045780
ATXN3
ataxin 3
1.90
2.327E−11
4287

PH_hs_0046019
MCTS1
malignant T cell amplified sequence 1
1.90
6.150E−06
28985

PH_hs_0016827
TTC28
tetratricopeptide repeat domain 28
1.90
4.945E−06
23331

PH_hs_0048634
GSN
gelsolin
1.90
4.097E−08
2934

PH_hs_0024657
MBD1
methyl-CpG binding domain protein 1
1.90
5.759E−09
4152

PH_hs_0010158
RGL2
ral guanine nucleotide dissociation stimulator-like 2
1.90
4.190E−05
5863

PH_hs_0046391
LOC389834|LOC10
ankyrin repeat domain 57 pseudogene|hypothetical LOC100510339|hypothetical LOC100509956
1.90
2.737E−07
389834|1005103

0510339|LOC10050

39|100509956

9956

PH_hs_0043844
EXTL2
exostoses (multiple)-like 2
1.90
3.831E−07
2135

PH_hs_0045850
TPM2
tropomyosin 2 (beta)
1.90
8.897E−12
7169

PH_hs_0046287
ALDH1L2
aldehyde dehydrogenase 1 family, member L2
1.90
2.363E−06
160428

PH_hs_0043249
BAK1
BCL2-antagonist/killer 1
1.90
2.484E−11
578

PH_hs_0000315
JUP
junction plakoglobin
1.90
1.837E−02
3728

PH_hs_0002107
ERMN
ermin, ERM-like protein
1.90
9.838E−06
57471

PH_hs_0009163
SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
1.91
5.003E−10
6594

PH_hs_0034349
PLSCR3
phospholipid scramblase 3
1.91
7.262E−11
57048

PH_hs_0048416
ENAH
enabled homolog (Drosophila)
1.91
1.555E−08
55740

PH_hs_0033391
MANF
mesencephalic astrocyte-derived neurotrophic factor
1.91
5.051E−09
7873

PH_hs_0033911
MZF1
myeloid zinc finger 1
1.91
1.191E−05
7593

PH_hs_0019842
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
1.91
2.811E−04
338328

PH_hs_0003154
TTC14
tetratricopeptide repeat domain 14
1.91
8.569E−10
151613

PH_hs_0013097
DDAH2
dimethylarginine dimethylaminohydrolase 2
1.91
2.184E−07
23564

PH_hs_0047815
FAM46A
family with sequence similarity 46, member A
1.92
5.944E−07
55603

PH_hs_0004256
TJP1
tight junction protein 1 (zona occludens 1)
1.92
1.259E−04
7082

PH_hs_0004673
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
1.92
7.208E−11
4982

PH_hs_0013717
SNX4
sorting nexin 4
1.92
1.718E−03
8723

PH_hs_0042038
RPS23
ribosomal protein S23
1.92
7.523E−09
6228

PH_hs_0004467
USP4
ubiquitin specific peptidase 4 (proto-oncogene)
1.92
1.294E−09
7375

PH_hs_0023373
ANTXR1
anthrax toxin receptor 1
1.92
4.346E−05
84168

PH_hs_0029280
C10orf11
chromosome 10 open reading frame 11
1.92
1.242E−08
83938

PH_hs_0001672
MRPS26
mitochondrial ribosomal protein S26
1.92
6.277E−04
64949

PH_hs_0011402
SETD6
SET domain containing 6
1.92
8.076E−05
79918

PH_hs_0022248
GOLGA1
golgin A1
1.92
1.566E−11
2800

PH_hs_0026107
ASNS
asparagine synthetase (glutamine-hydrolyzing)
1.92
1.037E−13
440

PH_hs_0049653
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
1.92
3.093E−05
56913

PH_hs_0023051
POMT1
protein-O-mannosyltransferase 1
1.92
7.706E−08
10585

PH_hs_0020406
NISCH
nischarin
1.92
5.466E−14
11188

PH_hs_0047101
LOC642414
putative tripartite motif-containing protein 64B-like
1.93
2.876E−05
642414

PH_hs_0006318
ZNF213
zinc finger protein 213
1.93
3.268E−06
7760

PH_hs_0028823
SRRM3
serine/arginine repetitive matrix 3
1.93
3.023E−02
222183

PH_hs_0047860
PURB
purine-rich element binding protein B
1.93
2.893E−13
5814

PH_hs_0017235
TMEM127
transmembrane protein 127
1.93
8.235E−12
55654

PH_hs_0023953
PAM
peptidylglycine alpha-amidating monooxygenase
1.93
3.004E−11
5066

PH_hs_0024186
PPP1R13B
protein phosphatase 1, regulatory (inhibitor) subunit 13B
1.93
2.494E−05
23368

PH_hs_0045707
DLG3
discs, large homolog 3 (Drosophila)
1.93
2.644E−08
1741

PH_hs_0011504
NFS1
NFS1 nitrogen fixation 1 homolog (S. cerevisiae)
1.94
4.496E−12
9054

PH_hs_0032829
TRNP1
TMF1-regulated nuclear protein 1
1.94
5.053E−03
388610

PH_hs_0047930
NUMBL
numb homolog (Drosophila)-like
1.94
9.113E−09
9253

PH_hs_0012900
PDCD11
programmed cell death 11
1.94
3.969E−04
22984

PH_hs_0029814
KCNK15
potassium channel, subfamily K, member 15
1.94
1.817E−04
60598

PH_hs_0047221
LPAR1
lysophosphatidic acid receptor 1
1.94
5.820E−11
1902

PH_hs_0019226
SOCS2
suppressor of cytokine signaling 2
1.94
4.846E−04
8835

PH_hs_0004725
CCDC106
coiled-coil domain containing 106
1.94
5.882E−10
29903

PH_hs_0024622
FBXO32
F-box protein 32
1.94
1.591E−04
114907

PH_hs_0042800
IER5L
immediate early response 5-like
1.95
3.788E−08
389792

PH_hs_0020451
ATP13A1
ATPasetype 13A1
1.95
2.001E−09
57130

PH_hs_0000889
C11orf54
chromosome 11 open reading frame 54
1.95
6.146E−11
28970

PH_hs_0028088
DMBT1
deleted in malignant brain tumors 1
1.95
1.821E−11
1755

PH_hs_0049298
RPS6KA3
ribosomal protein S6 kinase, 90 kDa, polypeptide 3
1.95
5.253E−10
6197

PH_hs_0048277
FXC1
fracture callus 1 homolog (rat)
1.95
4.129E−08
26515

PH_hs_0043125
ULBP1
UL16 binding protein 1
1.95
6.756E−06
80329

PH_hs_0026363
CHPF
chondroitin polymerizing factor
1.95
5.633E−15
79586

PH_hs_0024014
TCF4
transcription factor 4
1.96
5.984E−05
6925

PH_hs_0001088
ERRFI1
ERBB receptor feedback inhibitor 1
1.96
2.665E−11
54206

PH_hs_0024993
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial
1.96
1.066E−12
1666

PH_hs_0004400
AK1
adenylate kinase 1
1.96
6.811E−14
203

PH_hs_0046216
KLHL13
kelch-like 13 (Drosophila)
1.96
4.875E−09
90293

PH_hs_0048810
NCOA1
nuclear receptor coactivator 1
1.96
1.170E−13
8648

PH_hs_0002369
C1orf198
chromosome 1 open reading frame 198
1.97
5.537E−05
84886

PH_hs_0013583
LOC100509177|LO
hypothetical LOC100509177|hypothetical LOC100507143
1.97
1.420E−05
100509177|1005

C100507143

07143

PH_hs_0048372
KIAA0368
KIAA0368
1.97
3.641E−07
23392

PH_hs_0002565
PPAPDC2
phosphatidic acid phosphatase type 2 domain containing 2
1.97
4.478E−10
403313

PH_hs_0049716
ZNF84
zinc finger protein 84
1.97
4.885E−10
7637

PH_hs_0049733
FOXO3|FOXO3B
forkhead box O3|forkhead box O3B pseudogene
1.98
7.907E−07
2309|2310

PH_hs_0043347
AIG1
androgen-induced 1
1.98
1.289E−10
51390

PH_hs_0035778
C22orf9
chromosome 22 open reading frame 9
1.98
6.161E−14
23313

PH_hs_0022930
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
1.98
6.780E−06
134147

PH_hs_0022134
BEND6
BEN domain containing 6
1.98
6.104E−08
221336

PH_hs_0047693
SFT2D3
SFT2 domain containing 3
1.98
2.169E−10
84826

PH_hs_0049131
ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
1.99
9.064E−09
3685

PH_hs_0047284
LRP4
low density lipoprotein receptor-related protein 4
1.99
9.963E−04
4038

PH_hs_0001027
TRMT12
tRNA methyltransferase 12 homolog (S. cerevisiae)
1.99
5.773E−10
55039

PH_hs_0036686
VCY|VCY1B
variable charge, Y-linked|variable charge, Y-linked 1B
1.99
2.141E−08
9084|353513

PH_hs_0004062
TWIST1
twist homolog 1 (Drosophila)
1.99
2.279E−10
7291

PH_hs_0025209
TMEM165
transmembrane protein 165
1.99
7.612E−06
55858

PH_hs_0011591
ECH1
enoyl CoA hydratase 1, peroxisomal
1.99
4.743E−06
1891

PH_hs_0000821
LOC730101
hypothetical LOC730101
1.99
3.922E−09
730101

PH_hs_0004614
RPIA
ribose 5-phosphate isomerase A
2.00
8.202E−12
22934

PH_hs_0004782
MOGS
mannosyl-oligosaccharide glucosidase
2.00
1.991E−02
7841

PH_hs_0014094
PCIF1
PDX1 C-terminal inhibiting factor 1
2.00
4.306E−06
63935

PH_hs_0030400
NRBF2
nuclear receptor binding factor 2
2.00
8.640E−05
29982

PH_hs_0043177
TSHZ1
teashirt zinc finger homeobox 1
2.00
1.768E−02
10194

PH_hs_0047673
ATP8B2
ATPase, class I, type 8B, member 2
2.00
4.409E−07
57198

PH_hs_0003316
EPDR1
ependymin related protein 1 (zebrafish)
2.01
6.066E−05
54749

PH_hs_0005942
CALB2
calbindin 2
2.01
1.063E−05
794

PH_hs_0034220
ZFP62
zinc finger protein 62 homolog (mouse)
2.01
1.520E−04
643836

PH_hs_0023507
TMEM184A
transmembrane protein 184A
2.01
2.001E−03
202915

PH_hs_0046412
FLJ44606
glutaredoxin-like protein YDR286C homolog
2.02
3.321E−02
401207

PH_hs_0003641
RIPK4
receptor-interacting serine-threonine kinase 4
2.02
6.652E−03
54101

PH_hs_0023807
CASD1
CAS1 domain containing 1
2.02
1.538E−06
64921

PH_hs_0013600
C1orf63
chromosome 1 open reading frame 63
2.02
2.198E−10
57035

PH_hs_0017020
NANOS1
nanos homolog 1 (Drosophila)
2.02
4.103E−03
340719

PH_hs_0015639
GLIPR2
GLI pathogenesis-related 2
2.02
3.212E−13
152007

PH_hs_0043550
C1QTNF6
C1q and tumor necrosis factor related protein 6
2.03
3.959E−06
114904

PH_hs_0033165
IL28B|IL28A|IL29
interleukin 28B (interferon, lambda 3)|interleukin 28A (interferon, lambda 2)|interleukin 29 (interferon, lambda 1)
2.03
6.546E−03
282617|282616|

282618

PH_hs_0022868
NUB1
negative regulator of ubiquitin-like proteins 1
2.03
4.660E−08
51667

PH_hs_0020917
CORO2A
coronin, actin binding protein, 2A
2.03
1.062E−03
7464

PH_hs_0047989
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
2.03
3.244E−10
4150

PH_hs_0025770
SERP1
stress-associated endoplasmic reticulum protein 1
2.03
1.051E−10
27230

PH_hs_0033036
ZNF45
zinc finger protein 45
2.03
2.056E−05
7596

PH_hs_0019863
CA11
carbonic anhydrase XI
2.04
4.911E−08
770

PH_hs_0002737
DTX3
deltex homolog 3 (Drosophila)
2.04
1.470E−11
196403

PH_hs_0035189
ZNF251
zinc finger protein 251
2.04
9.418E−04
90987

PH_hs_0020096
C22orf39
chromosome 22 open reading frame 39
2.04
1.243E−14
128977

PH_hs_0042520
RNASE7
ribonuclease, RNase A family, 7
2.05
6.778E−06
84659

PH_hs_0032160
C17orf49
chromosome 17 open reading frame 49
2.05
1.966E−12
124944

PH_hs_0006209
PARD6A
par-6 partitioning defective 6 homolog alpha (C. elegans)
2.05
4.258E−12
50855

PH_hs_0020138
FSTL1
follistatin-like 1
2.05
1.168E−12
11167

PH_hs_0014474
ROM1
retinal outer segment membrane protein 1
2.05
2.580E−09
6094

PH_hs_0005160
MPZ
myelin protein zero
2.06
3.136E−07
4359

PH_hs_0009397
C3AR1
complement component 3a receptor 1
2.06
1.371E−06
719

PH_hs_0000410
PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
2.06
8.581E−09
11142

PH_hs_0044100
PEG10
paternally expressed 10
2.06
1.512E−08
23089

PH_hs_0044325
LNX1
ligand of numb-protein X 1
2.06
3.386E−04
84708

PH_hs_0010102
BAALC
brain and acute leukemia, cytoplasmic
2.07
1.745E−14
79870

PH_hs_0001121
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
2.07
1.507E−04
3156

PH_hs_0014732
HMOX2
heme oxygenase (decycling) 2
2.07
5.674E−04
3163

PH_hs_0030241
VASN
vasorin
2.07
5.365E−07
114990

PH_hs_0013514
PCYOX1L
prenylcysteine oxidase 1 like
2.07
1.923E−11
78991

PH_hs_0046338
C17orf58
chromosome 17 open reading frame 58
2.07
8.241E−13
284018

PH_hs_0049703
TRIM16|TRIM16L
tripartite motif-containing 16|tripartite motif-containing 16-like
2.08
8.751E−19
10626|147166

PH_hs_0000736
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
2.08
4.931E−09
54910

PH_hs_0014108
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
2.08
1.261E−05
9924

PH_hs_0027093
PTPRU
protein tyrosine phosphatase, receptor type, U
2.08
4.672E−14
10076

PH_hs_0043466
PRAF2
PRA1 domain family, member 2
2.08
9.335E−20
11230

PH_hs_0034204
LOC100510699|LO
putative beta-glucuronidase-like protein FLJ75429-like|hypothetical LOC100505643
2.08
3.868E−05
100510699|1005

C100505643

05643

PH_hs_0004397
CDH5
cadherin 5, type 2 (vascular endothelium)
2.08
9.410E−09
1003

PH_hs_0012803
ACOT11
acyl-CoA thioesterase 11
2.09
6.960E−07
26027

PH_hs_0049095
C6orf89
chromosome 6 open reading frame 89
2.09
6.783E−11
221477

PH_hs_0044597
RNLS
renalase, FAD-dependent amine oxidase
2.09
1.558E−08
55328

PH_hs_0043819
INO80C
INO80 complex subunit C
2.09
2.613E−17
125476

PH_hs_0031263
C21orf119
chromosome 21 open reading frame 119
2.09
3.737E−08
84996

PH_hs_0023822
OTUD7B
OTU domain containing 7B
2.09
1.545E−11
56957

PH_hs_0003929
C1orf213
chromosome 1 open reading frame 213
2.10
4.394E−04
148898

PH_hs_0019488
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
2.10
5.281E−09
84557

PH_hs_0048987
TEP1
telomerase-associated protein 1
2.10
7.392E−12
7011

PH_hs_0036845
ZFP90
zinc finger protein 90 homolog (mouse)
2.10
3.656E−04
146198

PH_hs_0000451
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
2.10
2.841E−15
93058

PH_hs_0030457
C14orf132
chromosome 14 open reading frame 132
2.10
5.548E−11
56967

PH_hs_0032425
FLJ41649
hypothetical LOC401260
2.10
3.776E−02
401260

PH_hs_0004437
PDIA5
protein disulfide isomerase family A, member 5
2.11
4.807E−12
10954

PH_hs_0049358
DKFZp686O24166
hypothetical protein DKFZp686O24166
2.11
7.020E−09
374383

PH_hs_0023823
GPC1
glypican 1
2.11
3.373E−11
2817

PH_hs_0002176
MOAP1
modulator of apoptosis 1
2.11
1.302E−17
64112

PH_hs_0003194
PELI2
pellino homolog 2 (Drosophila)
2.12
4.454E−05
57161

PH_hs_0048515
SHROOM3
shroom family member 3
2.12
2.480E−05
57619

PH_hs_0016793
TLCD1
TLC domain containing 1
2.12
4.102E−11
116238

PH_hs_0044378
ZNF34
zinc finger protein 34
2.13
2.273E−11
80778

PH_hs_0047462
C20orf112
chromosome 20 open reading frame 112
2.13
1.145E−07
140688

PH_hs_0033256
MAGEA6|MAGEA3|
melanoma antigen family A, 6|melanoma antigen family A, 3|melanoma antigen family A, 2|melanoma antigen family A,
2.13
4.248E−04
4105|4102|4101|

MAGEA2|MAGEA2
2B|melanoma antigen family A, 12|melanoma antigen family A, 5

266740|4111|41

B|MAGEA12|MAGE

04

A5

PH_hs_0036772
DUSP5P
dual specificity phosphatase 5 pseudogene
2.13
9.343E−10
574029

PH_hs_0048572
UBAP2L
ubiquitin associated protein 2-like
2.13
1.197E−08
9898

PH_hs_0035164
RPL22L1
ribosomal protein L22-like 1
2.14
1.362E−05
200916

PH_hs_0049240
TANC1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
2.14
6.461E−12
85461

PH_hs_0042352
DPH1
DPH1 homolog (S. cerevisiae)
2.14
5.487E−07
1801

PH_hs_0042138
TOP1MT
topoisomerase (DNA) I, mitochondrial
2.15
1.313E−10
116447

PH_hs_0048065
MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
2.15
2.730E−15
64087

PH_hs_0042096
KLF3
Kruppel-like factor 3 (basic)
2.15
4.295E−18
51274

PH_hs_0043410
C6orf120
chromosome 6 open reading frame 120
2.16
2.221E−03
387263

PH_hs_0005636
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
2.16
1.800E−07
7127

PH_hs_0034663
RORC
RAR-related orphan receptor C
2.16
4.647E−04
6097

PH_hs_0011427
BANK1
B-cell scaffold protein with ankyrin repeats 1
2.16
6.917E−09
55024

PH_hs_0026987
ZNF3
zinc finger protein 3
2.16
4.880E−15
7551

PH_hs_0033681
HSD17B1
hydroxysteroid (17-beta) dehydrogenase 1
2.16
3.834E−05
3292

PH_hs_0019504
MZB1
marginal zone B and B1 cell-specific protein
2.17
3.111E−11
51237

PH_hs_0032842
GOLGA8B|GOLGA8
golgin A8 family, member B|golgin A8 family, member A
2.17
3.102E−06
440270|23015

A

PH_hs_0049566
FCGR2C|FCGR2A
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)|Fc fragment of IgG, low affinity Ma, receptor
2.17
1.666E−05
9103|2212

(CD32)

PH_hs_0016105
NXF1
nuclear RNA export factor 1
2.17
1.038E−18
10482

PH_hs_0004859
POLR1B
polymerase (RNA) I polypeptide B, 128 kDa
2.18
4.434E−21
84172

PH_hs_0005094
PGAP3
post-GPI attachment to proteins 3
2.18
1.526E−10
93210

PH_hs_0025544
CHCHD7
coiled-coil-helix-coiled-coil-helix domain containing 7
2.19
1.002E−06
79145

PH_hs_0001926
IGSF1
immunoglobulin superfamily, member 1
2.20
1.517E−06
3547

PH_hs_0022674
SARM1
sterile alpha and TIR motif containing 1
2.20
7.343E−05
23098

PH_hs_0048310
ACACB
acetyl-CoA carboxylase beta
2.20
4.412E−09
32

PH_hs_0007296
FBRSL1
fibrosin-like 1
2.20
2.029E−07
57666

PH_hs_0044590
LRRTM1
leucine rich repeat transmembrane neuronal 1
2.21
1.253E−02
347730

PH_hs_0011345
FAM160B1
family with sequence similarity 160, member B1
2.21
3.142E−18
57700

PH_hs_0013259
ZNF219
zinc finger protein 219
2.21
4.108E−23
51222

PH_hs_0001482
CNKSR3
CNKSR family member 3
2.21
2.973E−06
154043

PH_hs_0043183
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
2.22
2.295E−02
5919

PH_hs_0010802
MAOA
monoamine oxidase A
2.22
2.957E−05
4128

PH_hs_0048914
VASH2
vasohibin 2
2.22
5.210E−13
79805

PH_hs_0048534
PRRT3
proline-rich transmembrane protein 3
2.22
1.530E−14
285368

PH_hs_0023814
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
2.23
3.883E−11
421

PH_hs_0015649
PPP1R3C
protein phosphatase 1, regulatory (inhibitor) subunit 3C
2.23
3.996E−12
5507

PH_hs_0006585
FLJ37453
hypothetical LOC729614
2.24
4.036E−18
729614

PH_hs_0043964
SDHD|LOC1005106
succinate dehydrogenase complex, subunit D, integral membrane protein|succinate dehydrogenase [ubiquinone]
2.24
9.084E−16
6392|100510603

03
cytochrome b small subunit, mitochondrial-like

PH_hs_0023677
KIAA1370
KIAA1370
2.24
1.360E−18
56204

PH_hs_0043352
ARID5B
AT rich interactive domain 5B (MRF1-like)
2.24
3.422E−09
84159

PH_hs_0048315
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
2.24
3.189E−02
501

PH_hs_0049579
FHL1|LOC10012816
four and a half LIM domains 1|four and a half LIM domains 1 pseudogene
2.24
3.608E−17
2273|100128164

4

PH_hs_0024448
RNASET2
ribonuclease T2
2.25
2.587E−09
8635

PH_hs_0048286
GPSM1
G-protein signaling modulator 1
2.25
7.803E−15
26086

PH_hs_0004279
ARFIP2
ADP-ribosylation factor interacting protein 2
2.25
1.516E−16
23647

PH_hs_0006351
PANK1
pantothenate kinase 1
2.25
5.179E−15
53354

PH_hs_0044630
DPM3
dolichyl-phosphate mannosyltransferase polypeptide 3
2.25
2.580E−08
54344

PH_hs_0000928
TMEM47
transmembrane protein 47
2.25
1.011E−14
83604

PH_hs_0000894
TRAF4
TNF receptor-associated factor 4
2.26
7.043E−08
9618

PH_hs_0048426
C5orf4
chromosome 5 open reading frame 4
2.28
6.610E−06
10826

PH_hs_0047163
LOC646903
hypothetical LOC646903
2.28
3.832E−03
646903

PH_hs_0031245
SEMA6C
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
2.28
1.147E−04
10500

PH_hs_0002744
FIBIN
fin bud initiation factor homolog (zebrafish)
2.28
1.079E−10
387758

PH_hs_0004117
CRIP2
cysteine-rich protein 2
2.29
9.078E−10
1397

PH_hs_0003170
OLFML2B
olfactomedin-like 2B
2.30
3.516E−10
25903

PH_hs_0015627
LOC100128822
hypothetical LOC100128822
2.30
3.077E−10
100128822

PH_hs_0023986
ZBED3
zinc finger, BED-type containing 3
2.30
3.868E−14
84327

PH_hs_0006081
PPIC
peptidylprolyl isomerase C (cyclophilin C)
2.30
1.216E−10
5480

PH_hs_0024897
C9orf3
chromosome 9 open reading frame 3
2.31
3.917E−22
84909

PH_hs_0033390
ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
2.31
1.362E−18
217

PH_hs_0022133
CH25H
cholesterol 25-hydroxylase
2.31
2.040E−06
9023

PH_hs_0003977
EMILIN1
elastin microfibril interfacer 1
2.32
4.220E−09
11117

PH_hs_0026049
CCDC25
coiled-coil domain containing 25
2.32
8.264E−06
55246

PH_hs_0022573
C20orf108
chromosome 20 open reading frame 108
2.33
4.187E−11
116151

PH_hs_0023733
CFI
complement factor I
2.33
1.923E−12
3426

PH_hs_0032079
SREBF1
sterol regulatory element binding transcription factor 1
2.34
3.370E−19
6720

PH_hs_0027959
RAB33B
RAB33B, member RAS oncogene family
2.34
3.235E−11
83452

PH_hs_0014152
OSBPL7
oxysterol binding protein-like 7
2.34
8.208E−09
114881

PH_hs_0043392
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
2.35
5.097E−11
4485

PH_hs_0023030
IL11RA
interleukin 11 receptor, alpha
2.35
1.589E−14
3590

PH_hs_0048783
RBMS3
RNA binding motif, single stranded interacting protein 3
2.35
1.340E−06
27303

PH_hs_0004330
BTG2
BTG family, member 2
2.35
2.267E−03
7832

PH_hs_0000450
KLHL24
kelch-like 24 (Drosophila)
2.36
1.005E−02
54800

PH_hs_0002217
C8orf55
chromosome 8 open reading frame 55
2.36
4.597E−17
51337

PH_hs_0024193
PNOC
prepronociceptin
2.36
1.578E−09
5368

PH_hs_0042673
SSC5D
scavenger receptor cysteine-rich glycoprotein
2.36
1.067E−03
284297

PH_hs_0046183
TUBA4B
tubulin, alpha 4b (pseudogene)
2.37
1.416E−11
80086

PH_hs_0035084
C8orf82
chromosome 8 open reading frame 82
2.37
5.209E−18
414919

PH_hs_0042901
C8orf85
chromosome 8 open reading frame 85
2.37
6.166E−11
441376

PH_hs_0048064
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
2.37
3.866E−21
2773

PH_hs_0048584
UQCRQ
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5 kDa
2.37
1.406E−05
27089

PH_hs_0000823
BTBD3
BTB (POZ) domain containing 3
2.37
3.863E−18
22903

PH_hs_0049536
SYS1-
SYS1-DBNDD2 read-through transcript|dysbindin (dystrobrevin binding protein 1) domain containing 2
2.38
1.836E−15
767557|55861

DBNDD2|DBNDD2

PH_hs_0045687
TMEM50B
transmembrane protein 50B
2.39
2.451E−22
757

PH_hs_0005174
ZNF580
zinc finger protein 580
2.39
5.629E−15
51157

PH_hs_0047661
RMND5A
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
2.40
5.614E−17
64795

PH_hs_0047501
CEP68
centrosomal protein 68 kDa
2.41
9.716E−16
23177

PH_hs_0047853
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
2.41
1.334E−08
3676

PH_hs_0001117
DHCR7
7-dehydrocholesterol reductase
2.41
1.863E−19
1717

PH_hs_0025402
LOC100507739|LO
hypothetical protein LOC100507739|hypothetical protein LOC100506584
2.41
8.618E−11
100507739|1005

C100506584

06584

PH_hs_0029926
IFITM3
interferon induced transmembrane protein 3 (1-8U)
2.42
1.763E−06
10410

PH_hs_0024827
FKBP7
FK506 binding protein 7
2.42
1.775E−03
51661

PH_hs_0043317
ZNF780B
zinc finger protein 780B
2.42
3.160E−06
163131

PH_hs_0032222
TCEA2
transcription elongation factor A (SII), 2
2.43
1.647E−12
6919

PH_hs_0026600
MCAM
melanoma cell adhesion molecule
2.43
5.394E−14
4162

PH_hs_0043577
RALGDS
ral guanine nucleotide dissociation stimulator
2.43
8.728E−17
5900

PH_hs_0002620
GAB2
GRB2-associated binding protein 2
2.44
6.651E−04
9846

PH_hs_0010073
TLX2
T-cell leukemia homeobox 2
2.45
4.051E−13
3196

PH_hs_0010551
OXCT1
3-oxoacid CoA transferase 1
2.45
1.030E−16
5019

PH_hs_0028982
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
2.45
1.727E−06
4776

PH_hs_0048516
AKT2
v-akt murine thymoma viral oncogene homolog 2
2.45
4.172E−14
208

PH_hs_0007721
GBGT1
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
2.46
1.028E−02
26301

PH_hs_0034629
GOLGA8G|GOLGA
golgin A8 family, member G|golgin A8 family, member E|golgin A8 family, member C|golgin A8 family, member D
2.46
4.044E−08
283768|390535|

8E|GOLGA8C|GOL
(pseudogene)

729786|1001329

GA8DP

79

PH_hs_0010130
THBS3
thrombospondin 3
2.47
3.653E−12
7059

PH_hs_0037351
LRRC8B
leucine rich repeat containing 8 family, member B
2.47
1.161E−03
23507

PH_hs_0024837
ALK
anaplastic lymphoma receptor tyrosine kinase
2.48
1.529E−12
238

PH_hs_0023592
TNFRSF25
tumor necrosis factor receptor superfamily, member 25
2.48
1.674E−12
8718

PH_hs_0000585
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
2.49
1.115E−15
3613

PH_hs_0022275
NNT
nicotinamide nucleotide transhydrogenase
2.49
8.497E−12
23530

PH_hs_0043571
FGF18
fibroblast growth factor 18
2.49
8.249E−17
8817

PH_hs_0023181
MEGF9
multiple EGF-like-domains 9
2.50
6.669E−16
1955

PH_hs_0001401
CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
2.50
1.522E−17
2055

PH_hs_0002930
PRPH
peripherin
2.50
7.181E−13
5630

PH_hs_0045355
NOVA1
neuro-oncological ventral antigen 1
2.51
5.560E−08
4857

PH_hs_0010165
C9orf91
chromosome 9 open reading frame 91
2.51
1.443E−07
203197

PH_hs_0043531
SDCBP2|FKBP1A-
syndecan binding protein (syntenin) 2|FKBP1A-SDCBP2 read-through transcript
2.52
2.938E−02
27111|10052803

SDCBP2

1

PH_hs_0036494
GDF11
growth differentiation factor 11
2.52
5.433E−10
10220

PH_hs_0002838
LOC100510620|LO
hypothetical LOC100510620|hypothetical LOC100505806
2.52
8.775E−03
100510620|1005

C100505806

05806

PH_hs_0046356
ZC3H12D
zinc finger CCCH-type containing 12D
2.52
1.513E−04
340152

PH_hs_0022824
CBS
cystathionine-beta-synthase
2.53
2.907E−09
875

PH_hs_0042024
LTC4S
leukotriene C4 synthase
2.53
5.579E−09
4056

PH_hs_0026552
NKIRAS2
NFKB inhibitor interacting Ras-like 2
2.53
4.443E−05
28511

PH_hs_0005573
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
2.54
1.630E−15
7091

PH_hs_0008177
ARPM1
actin related protein M1
2.55
2.096E−10
84517

PH_hs_0047844
JMY
junction mediating and regulatory protein, p53 cofactor
2.56
1.357E−10
133746

PH_hs_0002632
RTN4R
reticulon 4 receptor
2.56
6.548E−11
65078

PH_hs_0020570
PLK1S1
polo-like kinase 1 substrate 1
2.57
3.262E−03
55857

PH_hs_0010726
LOC283663
hypothetical LOC283663
2.57
3.149E−14
283663

PH_hs_0024020
FBP1
fructose-1,6-bisphosphatase 1
2.57
8.036E−07
2203

PH_hs_0024986
DBP
D site of albumin promoter (albumin D-box) binding protein
2.59
1.041E−07
1628

PH_hs_0006020
RAB38
RAB38, member RAS oncogene family
2.59
5.591E−08
23682

PH_hs_0022113
HNMT
histamine N-methyltransferase
2.59
6.475E−05
3176

PH_hs_0000672
HECA
headcase homolog (Drosophila)
2.59
1.240E−19
51696

PH_hs_0008735
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
2.60
1.138E−32
9709

PH_hs_0043702
IL4I1
interleukin 4 induced 1
2.61
5.545E−03
259307

PH_hs_0032271
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
2.62
1.965E−14
871

PH_hs_0032053
PCMTD2
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
2.62
1.743E−08
55251

PH_hs_0013714
VAV3
vav 3 guanine nucleotide exchange factor
2.62
5.423E−16
10451

PH_hs_0017289
CXXC5
CXXC finger protein 5
2.62
4.773E−07
51523

PH_hs_0043367
EBF1
early B-cell factor 1
2.63
2.407E−14
1879

PH_hs_0047712
YPEL2
yippee-like 2 (Drosophila)
2.64
8.930E−10
388403

PH_hs_0007590
BFSP1
beaded filament structural protein 1, filensin
2.65
3.302E−13
631

PH_hs_0014251
KCNT2
potassium channel, subfamily T, member 2
2.65
7.297E−04
343450

PH_hs_0030600
C5orf13
chromosome 5 open reading frame 13
2.65
5.858E−13
9315

PH_hs_0010868
STK38L
serine/threonine kinase 38 like
2.67
2.557E−12
23012

PH_hs_0000665
KIF5C
kinesin family member 5C
2.67
2.336E−17
3800

PH_hs_0005512
NTF3
neurotrophin 3
2.69
7.710E−09
4908

PH_hs_0001171
SYT13
synaptotagmin XIII
2.69
1.668E−08
57586

PH_hs_0011484
PALLD
palladin, cytoskeletal associated protein
2.69
1.162E−29
23022

PH_hs_0044091
TNFSF12
tumor necrosis factor (ligand) superfamily, member 12
2.70
1.382E−15
8742

PH_hs_0047838
IGFBP3
insulin-like growth factor binding protein 3
2.70
4.299E−24
3486

PH_hs_0024678
LUM
lumican
2.70
2.413E−08
4060

PH_hs_0014995
METTL7A
methyltransferase like 7A
2.71
3.915E−28
25840

PH_hs_0047451
KAZ
kazrin
2.71
2.906E−23
23254

PH_hs_0025416
TH
tyrosine hydroxylase
2.73
4.850E−14
7054

PH_hs_0025787
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
2.75
3.869E−04
288

PH_hs_0005136
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
2.75
4.178E−04
7941

PH_hs_0044320
ZNF44
zinc finger protein 44
2.75
1.545E−06
51710

PH_hs_0002451
PATZ1
POZ (BTB) and AT hook containing zinc finger 1
2.75
6.470E−24
23598

PH_hs_0000063
WWOX
WW domain containing oxidoreductase
2.77
1.938E−12
51741

PH_hs_0004441
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
2.77
2.671E−14
6622

PH_hs_0031374
KLF5
Kruppel-like factor 5 (intestinal)
2.78
6.622E−05
688

PH_hs_0049102
KCMF1
potassium channel modulatory factor 1
2.80
4.836E−16
56888

PH_hs_0034288
HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
2.80
3.228E−28
374875

PH_hs_0049706
ABCC6|ABCC6P2
ATP-binding cassette, sub-family C (CFTR/MRP), member 6|ATP-binding cassette, sub-family C, member 6 pseudogene
2.81
3.829E−06
368|730013

2

PH_hs_0018551
DDAH1
dimethylarginine dimethylaminohydrolase 1
2.82
9.493E−09
23576

PH_hs_0025514
RARB
retinoic acid receptor, beta
2.83
1.662E−06
5915

PH_hs_0004753
FASN
fatty acid synthase
2.83
8.159E−36
2194

PH_hs_0003251
GAL3ST4
galactose-3-O-sulfotransferase 4
2.85
1.143E−17
79690

PH_hs_0043311
KLHDC3
kelch domain containing 3
2.85
5.179E−19
116138

PH_hs_0026661
DUSP8
dual specificity phosphatase 8
2.85
2.407E−18
1850

PH_hs_0005107
WNT10B
wingless-type MMTV integration site family, member 10B
2.86
1.239E−13
7480

PH_hs_0005953
LPHN1
latrophilin 1
2.86
3.090E−16
22859

PH_hs_0027347
CTHRC1
collagen triple helix repeat containing 1
2.87
9.534E−07
115908

PH_hs_0001349
SESN1
sestrin 1
2.88
1.789E−09
27244

PH_hs_0004398
EFEMP1
EGF-containing fibulin-like extracellular matrix protein 1
2.88
4.258E−20
2202

PH_hs_0011876
PCOLCE
procollagen C-endopeptidase enhancer
2.89
5.904E−19
5118

PH_hs_0029707
KRTAP4-8|KRTAP4-
keratin associated protein 4-8|keratin associated protein 4-11
2.89
7.931E−13
728224|653240

11

PH_hs_0032521
ACSF2
acyl-CoA synthetase family member 2
2.91
2.628E−16
80221

PH_hs_0006423
SLC46A3
solute carrier family 46, member 3
2.92
5.778E−14
283537

PH_hs_0005145
ZNF608
zinc finger protein 608
2.94
5.480E−05
57507

PH_hs_0043781
ADAM21
ADAM metallopeptidase domain 21
2.94
4.853E−08
8747

PH_hs_0043599
DCLK2
doublecortin-like kinase 2
2.94
4.391E−23
166614

PH_hs_0042059
CALHM3
calcium homeostasis modulator 3
2.95
5.820E−03
119395

PH_hs_0027659
HSPB7
heat shock 27 kDa protein family, member 7 (cardiovascular)
2.97
5.117E−08
27129

PH_hs_0023711
HSPA5
heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)
2.98
1.110E−23
3309

PH_hs_0025905
C8orf44
chromosome 8 open reading frame 44
2.98
1.730E−18
56260

PH_hs_0044361
FAM179A
family with sequence similarity 179, member A
2.98
1.235E−22
165186

PH_hs_0047629
ZNF74
zinc finger protein 74
2.99
6.677E−17
7625

PH_hs_0031241
TNFSF13|TNFSF12-
tumor necrosis factor (ligand) superfamily, member 13|TNFSF12-TNFSF13 readthrough
3.00
3.526E−25
8741|407977

TNFSF13

PH_hs_0025600
EPB41L1
erythrocyte membrane protein band 4.1-like 1
3.03
2.260E−26
2036

PH_hs_0044803
C2orf68
chromosome 2 open reading frame 68
3.04
1.815E−12
388969

PH_hs_0048509
MFSD6
major facilitator superfamily domain containing 6
3.05
6.095E−20
54842

PH_hs_0028629
ERV3
endogenous retroviral sequence 3
3.05
7.309E−18
2086

PH_hs_0045976
SEPT6
septin 6
3.05
3.607E−08
23157

PH_hs_0024713
COL4A2
collagen, type IV, alpha 2
3.06
2.495E−17
1284

PH_hs_0000684
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
3.06
6.398E−19
4189

PH_hs_0037891
NCRNA00157
non-protein coding RNA 157
3.07
2.696E−03
54075

PH_hs_0046015
PDLIM3
PDZ and LIM domain 3
3.07
4.844E−03
27295

PH_hs_0014100
ADCK3
aarF domain containing kinase 3
3.07
6.298E−23
56997

PH_hs_0030129
PNKD
paroxysmal nonkinesigenic dyskinesia
3.07
2.548E−29
25953

PH_hs_0022416
FRZB
frizzled-related protein
3.08
4.430E−13
2487

PH_hs_0043719
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
3.09
4.084E−28
3157

PH_hs_0048642
PITPNM3
PITPNM family member 3
3.09
1.865E−03
83394

PH_hs_0026436
MXRA8
matrix-remodelling associated 8
3.10
4.649E−22
54587

PH_hs_0024709
MYB
v-myb myeloblastosis viral oncogene homolog (avian)
3.12
1.960E−12
4602

PH_hs_0001428
HEXIM1
hexamethylene bis-acetamide inducible 1
3.19
2.520E−12
10614

PH_hs_0049518
SPRR2C
small proline-rich protein 2C (pseudogene)
3.19
3.886E−08
6702

PH_hs_0042334
MT4
metallothionein 4
3.23
4.564E−14
84560

PH_hs_0044960
MGC21881
hypothetical locus MGC21881
3.24
7.026E−28
389741

PH_hs_0047981
DLX3
distal-less homeobox 3
3.24
2.926E−22
1747

PH_hs_0033195
FOXN3
forkhead box N3
3.25
1.798E−09
1112

PH_hs_0007383
F2R
coagulation factor II (thrombin) receptor
3.28
4.070E−15
2149

PH_hs_0048029
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
3.30
6.262E−21
1140

PH_hs_0000763
REEP1
receptor accessory protein 1
3.30
9.573E−03
65055

PH_hs_0005804
AQP9
aquaporin 9
3.31
1.817E−16
366

PH_hs_0034837
ARG2
arginase, type II
3.31
2.170E−15
384

PH_hs_0046456
TLCD2
TLC domain containing 2
3.33
3.518E−13
727910

PH_hs_0043744
CITED1
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
3.38
1.733E−18
4435

PH_hs_0033102
SORT1
sortilin 1
3.41
1.320E−21
6272

PH_hs_0010359
COL1A1
collagen, type I, alpha 1
3.42
3.730E−20
1277

PH_hs_0001086
TP53INP2
tumor protein p53 inducible nuclear protein 2
3.46
9.620E−13
58476

PH_hs_0010384
TMEM100
transmembrane protein 100
3.46
3.184E−20
55273

PH_hs_0000329
ANGPT1
angiopoietin 1
3.46
6.013E−21
284

PH_hs_0047559
ITGB8
integrin, beta 8
3.46
2.278E−12
3696

PH_hs_0033736
TMEM119
transmembrane protein 119
3.48
2.086E−24
338773

PH_hs_0048420
SNX18
sorting nexin 18
3.48
1.143E−17
112574

PH_hs_0046459
LOC728819
hCG1645220
3.50
6.811E−07
728819

PH_hs_0047533
MFAP5
microfibrillar associated protein 5
3.50
2.947E−13
8076

PH_hs_0046308
FAM13C
family with sequence similarity 13, member C
3.58
5.102E−09
220965

PH_hs_0031653
LIMS2
LIM and senescent cell antigen-like domains 2
3.59
1.374E−08
55679

PH_hs_0048185
DPP6
dipeptidyl-peptidase 6
3.61
2.384E−06
1804

PH_hs_0000920
FBLIM1
filamin binding LIM protein 1
3.68
7.659E−16
54751

PH_hs_0026234
VWA1
von Willebrand factor A domain containing 1
3.72
1.855E−15
64856

PH_hs_0043711
ACTA2
actin, alpha 2, smooth muscle, aorta
3.72
0.000E+00
59

PH_hs_0046297
SYNPO2
synaptopodin 2
3.73
2.020E−04
171024

PH_hs_0009308
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
3.76
0.000E+00
1545

PH_hs_0048576
MYLIP
myosin regulatory light chain interacting protein
3.77
5.301E−19
29116

PH_hs_0023462
COL5A2
collagen, type V, alpha 2
3.84
1.065E−17
1290

PH_hs_0043411
IFITM2
interferon induced transmembrane protein 2 (1-8D)
3.84
3.613E−26
10581

PH_hs_0001688
LOC400043
hypothetical LOC400043
3.89
1.155E−16
400043

PH_hs_0005971
DOCK11
dedicator of cytokinesis 11
3.89
6.017E−24
139818

PH_hs_0049351
C17orf103
chromosome 17 open reading frame 103
3.91
5.331E−29
256302

PH_hs_0027738
PCDH18
protocadherin 18
3.92
3.262E−17
54510

PH_hs_0042917
MT1M|MT1JP
metallothionein 1M|metallothionein 1J (pseudogene)
3.93
7.594E−12
4499|4498

PH_hs_0018667
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
3.94
9.415E−42
1116

PH_hs_0043472
GTF2IRD1
GTF2I repeat domain containing 1
3.94
8.077E−28
9569

PH_hs_0023673
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
3.97
9.328E−18
5159

PH_hs_0049327
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic
4.02
2.869E−37
9037

domain, (semaphorin) 5A

PH_hs_0025365
TRO
trophinin
4.03
1.166E−13
7216

PH_hs_0016327
NAPRT1
nicotinate phosphoribosyltransferase domain containing 1
4.06
1.289E−43
93100

PH_hs_0025862
GLUL
glutamate-ammonia ligase
4.07
2.841E−24
2752

PH_hs_0044095
AQP1
aquaporin 1 (Colton blood group)
4.08
8.334E−19
358

PH_hs_0026812
CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
4.13
1.153E−10
634

PH_hs_0048943
SLC26A4
solute carrier family 26, member 4
4.14
6.415E−09
5172

PH_hs_0004650
NTS
neurotensin
4.16
0.000E+00
4922

PH_hs_0042871
SAMD5
sterile alpha motif domain containing 5
4.17
5.374E−23
389432

PH_hs_0018380
LOC100128288
hypothetical LOC100128288
4.18
5.220E−26
100128288

PH_hs_0000178
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
4.18
1.939E−18
943

PH_hs_0002147
CXCL14
chemokine (C-X-C motif) ligand 14
4.19
7.903E−14
9547

PH_hs_0047359
EPHA5
EPH receptor A5
4.31
4.231E−15
2044

PH_hs_0004979
MSX2
msh homeobox 2
4.39
8.493E−25
4488

PH_hs_0015557
PLXND1
plexin D1
4.43
2.090E−10
23129

PH_hs_0004661
S100A4
S100 calcium binding protein A4
4.52
1.578E−27
6275

PH_hs_0001210
FAM59A
family with sequence similarity 59, member A
4.54
6.416E−07
64762

PH_hs_0049690
CT45A3|CT45A5|CT
cancer/testis antigen family 45, member A3|cancer/testis antigen family 45, member A5|cancer/testis antigen family 45,
4.60
7.478E−27
441519|441521|

45A1|CT45A2|CT45
member A1|cancer/testis antigen family 45, member A2|cancer/testis antigen family 45, member A4|cancer/testis antigen

541466|728911|

A4|CT45A6
family 45, member A6

441520|541465

PH_hs_0000109
DMPK
dystrophia myotonica-protein kinase
4.61
1.152E−14
1760

PH_hs_0029735
ZNF354A
zinc finger protein 354A
4.62
7.967E−35
6940

PH_hs_0045768
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
4.65
2.451E−09
3955

PH_hs_0048356
PRUNE2
prune homolog 2 (Drosophila)
4.67
1.904E−35
158471

PH_hs_0016832
FOXC1
forkhead box C1
4.84
1.498E−30
2296

PH_hs_0044922
HBE1
hemoglobin, epsilon 1
4.84
2.811E−15
3046

PH_hs_0048721
TLR4
toll-like receptor 4
4.85
8.187E−19
7099

PH_hs_0034338
MST1|MST1P2
macrophage stimulating 1 (hepatocyte growth factor-like)|macrophage stimulating 1 (hepatocyte growth factor-like)
4.90
3.752E−19
4485|11209

pseudogene 2

PH_hs_0032306
HOXC8
homeobox C8
4.94
5.682E−19
3224

PH_hs_0005473
RCOR2
REST corepressor 2
5.02
1.791E−18
283248

PH_hs_0049120
SORL1
sortilin-related receptor, L(DLR class) A repeats-containing
5.06
5.157E−10
6653

PH_hs_0005110
FRMPD4
FERM and PDZ domain containing 4
5.12
1.692E−10
9758

PH_hs_0003256
DPP4
dipeptidyl-peptidase 4
5.25
8.238E−31
1803

PH_hs_0047293
COL14A1
collagen, type XIV, alpha 1
5.30
1.963E−19
7373

PH_hs_0004689
MDK
midkine (neurite growth-promoting factor 2)
5.33
2.692E−32
4192

PH_hs_0044718
BCL2L11
BCL2-like 11 (apoptosis facilitator)
5.33
1.265E−27
10018

PH_hs_0019846
TP53
tumor protein p53
5.49
1.540E−28
7157

PH_hs_0010329
DLX4
distal-less homeobox 4
5.50
0.000E+00
1748

PH_hs_0048809
SGCD
sarcoglycan, delta (35 kDa dystrophin-associated glycoprotein)
5.55
7.219E−35
6444

PH_hs_0005015
UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
5.56
9.899E−13
7363

PH_hs_0032424
CALCB
calcitonin-related polypeptide beta
5.58
0.000E+00
797

PH_hs_0018212
CD24
CD24 molecule
5.61
4.334E−22
100133941

PH_hs_0049248
PIK3R3
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
5.80
2.365E−18
8503

PH_hs_0024090
MEF2C
myocyte enhancer factor 2C
5.86
6.404E−43
4208

PH_hs_0013486
BIRC7
baculoviral IAP repeat-containing 7
5.98
2.513E−17
79444

PH_hs_0018971
SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
6.02
0.000E+00
9368

PH_hs_0049050
PCDH7
protocadherin 7
6.04
1.538E−29
5099

PH_hs_0044562
ABLIM1
actin binding LIM protein 1
6.12
1.623E−30
3983

PH_hs_0031763
THY1
Thy-1 cell surface antigen
6.30
8.381E−18
7070

PH_hs_0042224
CKB
creatine kinase, brain
6.47
4.759E−42
1152

PH_hs_0046222
MEX3A
mex-3 homolog A (C. elegans)
6.51
3.279E−21
92312

PH_hs_0048541
CCDC69
coiled-coil domain containing 69
6.55
2.060E−28
26112

PH_hs_0047226
ZNF229
zinc finger protein 229
6.58
2.415E−04
7772

PH_hs_0003115
F2RL2
coagulation factor II (thrombin) receptor-like 2
6.59
4.881E−33
2151

PH_hs_0010156
FOXO1
forkhead box O1
6.82
1.157E−14
2308

PH_hs_0004671
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
6.96
7.296E−37
3815

PH_hs_0036356
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
7.12
0.000E+00
3604

PH_hs_0004774
CD33
CD33 molecule
7.53
1.370E−40
945

PH_hs_0006956
EPHA3
EPH receptor A3
7.53
0.000E+00
2042

PH_hs_0048149
ALX4
ALX homeobox 4
7.62
8.080E−32
60529

PH_hs_0044625
CALCA
calcitonin-related polypeptide alpha
7.63
3.890E−12
796

PH_hs_0023865
QPRT
quinolinate phosphoribosyltransferase
8.31
3.435E−39
23475

PH_hs_0049151
CELF2
CUGBP, Elav-like family member 2
8.36
0.000E+00
10659

PH_hs_0000718
CBLN2
cerebellin 2 precursor
8.73
1.580E−39
147381

PH_hs_0003183
SULF2
sulfatase 2
9.21
4.223E−15
55959

PH_hs_0011497
WISP2
WNT1 inducible signaling pathway protein 2
9.27
4.484E−44
8839

PH_hs_0047211
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
9.69
7.006E−45
11320

PH_hs_0047434
ARHGAP28
Rho GTPase activating protein 28
10.03
4.151E−29
79822

PH_hs_0001045
CGNL1
cingulin-like 1
10.41
5.063E−26
84952

PH_hs_0048430
MAF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
10.52
2.694E−11
4094

PH_hs_0009405
RCAN2
regulator of calcineurin 2
11.10
7.006E−45
10231

PH_hs_0047260
COL1A2
collagen, type I, alpha 2
11.26
0.000E+00
1278

PH_hs_0033279
CSAG1|CSAG2|CS
chondrosarcoma associated gene 1|CSAG family, member 2|CSAG family, member 3
11.88
1.415E−15
158511|728461|

AG3

389903

PH_hs_0000559
GPM6B
glycoprotein M6B
11.94
1.514E−14
2824

PH_hs_0009093
CTNNA2
catenin (cadherin-associated protein), alpha 2
12.75
0.000E+00
1496

PH_hs_0024012
SOX4
SRY (sex determining region Y)-box 4
12.86
1.892E−26
6659

PH_hs_0045549
CSAG1
chondrosarcoma associated gene 1
13.78
0.000E+00
158511

PH_hs_0005438
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
14.40
0.000E+00
120114

PH_hs_0042964
UBE2QL1
ubiquitin-conjugating enzyme E2Q family-like 1
15.93
0.000E+00
134111

PH_hs_0024799
SULF1
sulfatase 1
16.35
5.879E−20
23213

PH_hs_0035318
PRL
prolactin
16.66
1.067E−22
5617

PH_hs_0023510
LRRC17
leucine rich repeat containing 17
21.54
0.000E+00
10234

PH_hs_0022287
APOE
apolipoprotein E
24.59
0.000E+00
348

PH_hs_0025581
COL4A1
collagen, type IV, alpha 1
30.33
1.375E−22
1282

PH_hs_0023535
NUP210
nucleoporin 210 kDa
34.18
5.084E−24
23225

PH_hs_0044518
MTUS1
microtubule associated tumor suppressor 1
46.14
2.767E−10
57509

PH_hs_0025910
COL3A1
collagen, type III, alpha 1
75.99
0.000E+00
1281

PH_hs_0005961
CCDC3
coiled-coil domain containing 3
94.19
0.000E+00
83643

CAVEOLIN-1 RELATED METHODS FOR TREATING GLIOBLASTOMA WITH TEMOZOLOMIDE

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Publication Number

Date Filed

Date Published

Inventors

Original Assignees

CPC

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Abstract

Description

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Parent Case Info

PCT Information

Provisional Applications (1)