Claims
- 1. A system for the treatment of wounds, comprising:
a) transformed cells on a solid support; b) an enclosure, said enclosure housing said solid support; and c) means for removing said enclosure from a wound.
- 2. The system of claim 1, wherein said solid support comprises beads.
- 3. The system of claim 2, wherein said beads are macroporous.
- 4. The system of claim 3, wherein said beads are polyethylene.
- 5. The system of claim 1, wherein said enclosure comprises a mesh material, having pores.
- 6. The system of claim 5, wherein said mesh material comprises polyethylene.
- 7. The system of claim 1, wherein said enclosure comprises a biocompatible membrane.
- 8. The system of claim 1, wherein said transformed cells are selected from the group consisting of fibroblasts, keratinocytes, endothelial cells, melanocytes, smooth muscle cells, fetal fibroblasts, epithelial cells and combinations thereof.
- 9. The system of claim 1, wherein said removal means comprises a string attached to said enclosure.
- 10. The system of claim 1, wherein said transformed cells are cells transfected with a gene encoding a protein selected from the group consisting of EGF, VEGF, FGF, PDGF, IGF, KGF, IFN-α, IFN-δ, MSH, TGF-α, TGF-β, TNF-α, IL-1 and IL-6.
- 11. A method for treating a wound, comprising the step of positioning the system of claim 1 in a wound under conditions such that the healing of the wound is promoted.
- 12. A method for treating a wound, comprising:
a) providing: i) transformed cells on a solid support, ii) an enclosure comprising mesh material having pores, and iii) a subject having at least one wound; b) placing said transformed cell-containing solid support into said enclosure so as to produce a transformed cell-containing enclosure; c) sealing said enclosure to produce a sealed transformed cell-containing enclosure; d) positioning said sealed transformed cell-containing enclosure in the wound of said subject under conditions such that the healing of the wound is promoted; and e) removing said sealed transformed cell-containing enclosure from said wound after healing is promoted.
- 13. The method of claim 12, wherein said solid support is beads and said beads are mancroporous.
- 14. The method of claim 13, wherein said beads are polyethylene.
- 15. The method of claim 13, wherein said mesh material comprises polyethylene.
- 16. The method of claim 13, wherein said enclosure comprises a biocompatible membrane.
- 17. The method of claim 13, further comprising covering said sealed transformed cell-containing enclosure after positioning in step (c) in said wound with a dressing, and removing said dressing with said sealed transformed cell-containing enclosure in step (c).
- 18. The method of claim 12, wherein said transformed cells are cells transfected with a gene encoding a protein selected from the group consisting of EGF, VEGF, FGF, PDGF, IGF, KGF, IFN-α, IFN-δ, MSH, TGF-α, TGF-β, TNF-α, IL-1 and IL-6.
- 19. The method of claim 12, wherein said transformed cells are selected from the group consisting of fibroblasts, keratinocytes, endothelial cells, melanocytes, smooth muscle cells, fetal fibroblasts, epithelial cells and combinations thereof.
RELATED APPLICATIONS
[0001] This is a continuation-in-part of U.S. Ser. No. 09/323,188 which is a continuation-in-part of U.S. Ser. No. 08/840,804, filed Apr. 16, 1997, which is expressly incorporated by reference herein.
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
09323188 |
May 1999 |
US |
Child |
09502479 |
Feb 2000 |
US |
Parent |
08840804 |
Apr 1997 |
US |
Child |
09323188 |
May 1999 |
US |