Claims
- 1. A cephemcarboxylic acid ester of the formula I ##STR37## in which m denotes 0 or 1,
- R.sup.1 denotes hydrogen or methyl and
- R.sup.2 denotes C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl or the group
- --(CH.sub.2).sub.n --OR.sup.3
- in which n stands for 0 or 1 and R.sup.3 has the meaning of C.sub.1 -C.sub.6 -alkyl, which can also be further substituted by phenyl, or of C.sub.3 -C.sub.4 -alkenyl,
- in which the HO group is in the syn-position and, if m is 0 and R.sup.1 is hydrogen, R.sup.2 cannot be methyl physiologically tolerated acid addition salts thereof or their diastereomers.
- 2. A cephemcarboxylic acid ester as claimed in claim 1, in which R.sup.1 and m have the meaning given there and R.sup.2 stands for C.sub.1 -C.sub.4 -alkyl, C.sub.2 -C.sub.4 -alkenyl, C.sub.3 -C.sub.4 -alkynyl or the group
- --(CH.sub.2).sub.n --OR.sup.3
- in which n is 0 or 1 and R.sup.3 has the meaning of C.sub.1 -C.sub.4 -alkyl, which can also be further substituted by phenyl, or of C.sub.3 -C.sub.4 -alkenyl.
- 3. 2,2-Dimethyl-butanoyl-oxymethyl 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroxyimino-acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate.
- 4. 2,2-Dimethyl-3-butenoyl-oxymethyl 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroxyimino-acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate.
- 5. .alpha.-(2,2-Dimethyl-butanoyloxy)-ethyl 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroxyimino-acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate.
- 6. .alpha.-(2,2-Dimethyl-propionyloxy)-ethyl 7-[2-(2-aminothiazol-4-yl)-2-(Z)-hydroxyimino-acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate and its diastereomers.
- 7. A pharmaceutical formulation which is active against bacterial infections, which contains a cephemcarboxylic acid ester of the formula I as claimed in claim 1 together with a pharmaceutically acceptable carrier.
- 8. A method of combating bacterial infections which comprises administering an effective amount of a cephemcarboxylic acid ester of the formula I as claimed in claim 1.
- 9. A cephemcarboxylic acid as claimed in claim 1, in which m denotes O, R.sup.1 denotes hydrogen or methyl and R.sup.2 denotes C.sub.1 -C.sub.4 alkyl.
- 10. A cephemcarboxylic acid as claimed in claim 1, in which m denotes O, R.sup.1 denotes hydrogen or methyl and R.sup.2 denotes methyl or ethyl.
- 11. A cephemcarboxylic acid as claimed in claim 1, in which m denotes O, R.sup.1 methyl and R.sup.2 denotes methyl.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3804841 |
Feb 1988 |
DEX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/310,437, filed Feb. 15, 1989 now abandoned.
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts, vol. 97, 162705p (1982). |
Continuations (1)
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Number |
Date |
Country |
Parent |
310437 |
Feb 1989 |
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