Claims
- 1. A process for the preparation of a compound of formula (I) as defined below which process comprises:
- (a) treating a compound of formula (II) or a salt thereof: ##STR23## wherein R.sup.1 I CO.sub.2 R.sup.3, R.sup.4, m, n, and X are as hereinbefore defined with respect to formula (I) in claim 1, wherein any reactive group may be protected, and wherein the amino group is optionally substituted with a group which permits acylation to take place, with an N-acylating derivative of an acid of formula (III):
- R.sup.2 OH (III)
- wherein R.sup.2 is as hereinbefore defined with respect to formula (I) in claim 1 and wherein any reactive group may be protected; or
- (b) cyclising a compound of formula (IV): ##STR24## wherein X, R.sup.1, R.sup.2, R.sup.4, m, n and CO.sub.2 R.sup.3 are as hereinbefore defined with respect to formula (I) in claim 1 and P' is a phosphorus residue; or
- (c) treating a compound of formula (X): ##STR25## wherein R.sup.1, R.sup.2, CO.sub.2 R.sup.3 and X are as hereinbefore defined with respect to formula (I) in claim 1, and L is a leaving group, with a compound of formula (XI): ##STR26## wherein Z is an organo-cuprate group and R.sup.4 and m are as hereinbefore defined with respect to formula (I) in claim 1; and thereafter, if necessary or desired, carrying out one of the following steps:
- i) removing any protecting groups;
- ii) converting the group CO.sub.2 R.sup.3 to a different group CO.sub.2 R.sup.3 ;
- iii) converting the group R.sup.2 to a different group R.sup.2 ;
- iv) converting the group X to a different group X;
- v) converting the product into a salt.
- 2. A process for the preparation of a compound of formula (I) substantially as hereinbefore described in the preparative Examples.
Priority Claims (2)
Number |
Date |
Country |
Kind |
9016189 |
Jul 1990 |
GBX |
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9109540 |
May 1991 |
GBX |
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Parent Case Info
The present application is a continuation of prior application, Ser. No. 08/958,864, filed Oct. 20, 1997, which is a continuation of prior application Ser. No. 08/470,786, filed Jun. 06, 1995, now abandoned, which is a continuation of prior application Ser. No. 07/934,667, filed Jan. 22, 1993, now abandoned, which was a national stage filing under USC 371 of International Application No. PCT/GB91/01171 filed Jul. 22, 1991.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3959267 |
Nyler et al. |
May 1976 |
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5602117 |
Burton et al. |
Feb 1997 |
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Continuations (3)
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Parent |
958864 |
Oct 1997 |
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Parent |
470786 |
Jun 1995 |
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Parent |
934667 |
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