Claims
- 1. A cephem compound of the following formula (I), or a salt thereof: ##STR6## wherein R.sup.1 is a phenyl(lower)alkyl,
- R.sup.2 is a thiazolyl substituted by carboxy(lower)alkyl, thiazolyl substituted by carbamoyl(lower)alkyl, or thiazolyl substituted by N,N-di(lower)alkylcarbamoyl(lower)alkyl, and
- R.sup.3 is carboxy.
- 2. A method for the prophylactic and/or therapeutic treatment of the diseases caused by Helicobacter pylori infection which comprises administering a cephem compound of claim 1 or a pharmaceutically acceptable salt thereof to a human being or an animal.
- 3. A method for treatment or inhibition of the diseases caused by Helicobacter pylori infection which comprises administering an effective amount of the cephem compound (I) of claim 1 to a patient in need of said treatment or inhibition.
- 4. A process for preparing a compound of claim 1, or a salt thereof, which comprises
- (i) reacting a compound of the formula (II): ##STR7## wherein R.sup.1 and R.sup.3 are each as defined in claim 1, and
- R.sup.4 is a leaving group,
- or a salt thereof, with a compound of the formula (III):
- HS--R.sup.2 (III)
- wherein R.sup.2 is defined in claim 1, or a salt thereof, or
- (ii) subjecting a compound of the formula (Ia): ##STR8## wherein R.sup.1 and R.sup.2 are each as defined in claim 1, and
- R.sup.5 is protected carboxy,
- or a salt thereof, to elimination reaction of the carboxy-protective group, to give a compound of the formula (Ib): ##STR9## wherein R.sup.1 and R.sup.2 are each as defined in claim 1, or a salt thereof, or
- (iii) reacting a compound of the formula (IV): ##STR10## wherein R.sup.2 and R.sup.3 are each as defined in claim 1, or its reactive derivative at the amino-group or a salt thereof, with a compound of the formula (V):
- R.sup.1 --COOH (V)
- wherein R.sup.1 is defined in claim 1, or its reactive derivative at the carboxy-group or a salt thereof, or
- (iv) subjecting a compound of the formula (Ib): ##STR11## wherein R.sup.1 and R.sup.2 are each as defined in claim 1, or its reactive derivative at the carboxy group or a salt thereof, to protecting reaction of the carboxy, to give a compound of the formula (Ia): ##STR12## wherein R.sup.1 and R.sup.2 are each as defined in claim 1, and
- R.sup.5 is as defined above,
- or a salt thereof.
- 5. A compound of claim 1, wherein
- R.sup.1 is phenyl(lower)alkyl,
- R.sup.2 is thiazolyl substituted by carbamoyl(lower)alkyl, and
- R.sup.3 is carboxy.
- 6. A pharmaceutical composition which comprises, as an active ingredient, a compound of claim 1 or a pharmaceutically acceptable salt thereof in admixture with pharmaceutically acceptable carriers or excipients.
- 7. A compound of claim 5, which is
- 7.beta.-(2-Phenylacetamido)-3-(4-carbamoylmethylthiazolyl)thio-3-cephem-4-carboxylic acid.
Priority Claims (1)
Number |
Date |
Country |
Kind |
PN8011 |
Feb 1996 |
AUX |
|
Parent Case Info
This application is a 371 application of PCT/JP97/00280, filed Feb. 5, 1997.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/JP97/00280 |
2/5/1997 |
|
|
8/12/1998 |
8/12/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/29111 |
8/14/1997 |
|
|
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5162521 |
Farina |
Nov 1992 |
|
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