Claims
- 1. A compound having the formula: ##STR30## where: R' is a chemically reactive group that is able to react directly with a diagnostically or therapeutically effective agent without activation of the group prior to conjugation with the agent;
- W is a methylene, methylenoxy, or methylenecarbonyl group or combinations thereof;
- n is 0 to 10;
- Q.sub.1, Q.sub.2 and Q.sub.3 are independently selected from H, OH, O-alkyl, and O-acyl, with the proviso that Q.sub.1, Q.sub.2 and Q.sub.3 are not all H;
- n' is 1 to 2;
- X is H, an alkyl group of C.sub.6 or less, or alkoxy group of C.sub.6 or less; and
- R is a chemically reactive group that is able to react directly with a targeting molecule without activation of the group prior to conjugation with the targeting molecule, with the provisos that R is attached directly or indirectly to one of the carbons designated .alpha., .beta. or .gamma., that when R is attached to .alpha. then Q.sub.1 is H, that when R is attached to .beta. then Q.sub.2 is H, that when R is attached to .gamma. then Q.sub.3 is H, and that R and R' are not the same.
- 2. A compound having the formula: ##STR31## where: R is a chemically reactive group that is able to react directly without activation of the group prior to conjugation with a molecule;
- W is a methylene, methylenoxy, or methylenecarbonyl group or combinations thereof;
- n is 0 to 30;
- Y' is S, N, or O;
- X is H, alkyl group of C.sub.6 or less, or alkoxy group of C.sub.6 or less;
- n' is 1 to 2; and
- Y is an O, S or NR', wherein R' is an alkyl group of C.sub.6 or less.
- 3. A compound having the formula: ##STR32## where: R is a chemically reactive group that is able to react directly without activation of the group prior to conjugation with a molecule;
- W is a methylene, methylenoxy, or methylenecarbonyl group or combinations thereof;
- n is 0 to 30;
- Y is S, N, or O;
- X is H, alkyl group of C.sub.6 or less, or alkoxy group of C.sub.6 or less;
- n' is 1 to 2; and
- Q.sub.1, Q.sub.2 and Q.sub.3 are independently selected from H, OH, O-alkyl, O-acyl, and derivatives thereof, with the proviso that Q.sub.1, Q.sub.2 and Q.sub.3 are not all H.
CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation of U.S. patent application Ser. No. 07/915,004, filed Jul. 16, 1992 now abandoned; which is a division of Ser. No. 07/678,535, filed Mar. 29, 1991, now U.S. Pat. No. 5,141,648, which is a division of Ser. No. 07/454,295, filed Dec. 19, 1989, issued as U.S. Pat. No. 5,017,693; which is a continuation-in-part application to Ser. No. 07/362,355, filed Jun. 6, 1989, abandoned, and Ser. No. 07/127,656, filed Dec. 2, 1987, abandoned.
US Referenced Citations (17)
Non-Patent Literature Citations (9)
Entry |
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Elbein (1984) CRC Crit. Rev. Biochem. 16(1):21-49. |
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Banthorpe et al. "On the Structure of a Novel Ether From Artemisia Tridentata", Phytochemistry 18:666-667 (1979). |
Duncan et al., "A New Reagent Which May Be Used to Introduce Sulfhydryl Groups into Proteins, and Its Use in the Preparation of Conugates for Immunoassay," Anal. Biochem. 132:68-73 (1983). |
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Divisions (2)
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Number |
Date |
Country |
Parent |
678535 |
Mar 1991 |
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Parent |
454295 |
Dec 1989 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
915004 |
Jul 1992 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
362355 |
Jun 1989 |
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